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33results about How to "Deepen understanding" patented technology

Phase change thermoacoustic engine experimental device

The utility model relates to a phase change thermo-acoustic engine experimental device which comprises a thermo-acoustic conversion system and an acoustic-electric conversion system. The thermo-acoustic conversion system comprises a sound production module and a Helmholtz resonant cavity, a ceramic plate stack soaked with water exists in the sound production module, and the stable temperature difference needed for generating the thermo-acoustic effect at the two ends of the ceramic plate stack is reduced. Sound waves generated by the thermoacoustic effect form standing waves in the Helmholtz resonant cavity, and the sound intensity is amplified; the acoustic-electric conversion system comprises piezoelectric ceramics and a triode common-emitter amplification circuit, the piezoelectric ceramics are arranged at the tail end of the resonant cavity and convert acoustic energy into electric energy, and the electric energy is amplified by the triode common-emitter amplification circuit and then drives a nixie tube to display. The experimental device integrates thermodynamics, fluid mechanics, acoustics, material science and electronic technology, has the characteristics of simple structure, low cost, rich physical process and strong exploration, is suitable for experimental teaching, particularly suitable for new engineering teaching requirements, and is beneficial to improving the multidisciplinary cross practice ability of students.
Owner:NANKAI UNIV

Application of saposhnikovia divaricata c2' h gene and method for increasing coumarin content in saposhnikovia divaricata

ActiveCN120866338BIncrease contentdeepen understandingCoumarin synthesisCloned genes
The application discloses application of a SdC2'H gene of Saposhnikovia divaricata and a method for increasing coumarin content in Saposhnikovia divaricata, and belongs to the technical field of bio-agriculture. The SdC2'H gene of Saposhnikovia divaricata and the biological material containing the SdC2'H gene are applied to the regulation of coumarin synthesis in Saposhnikovia divaricata. The method for increasing coumarin content in Saposhnikovia divaricata comprises the steps of increasing the expression amount and / or activity of the SdC2'H gene in Saposhnikovia divaricata. The SdC2'H gene is successfully cloned from Saposhnikovia divaricata for the first time, and a gene overexpression vector is constructed. The SdC2'H gene is positively regulated to control the synthesis of coumarin for the first time, and overexpression of the SdC2'H gene can significantly increase the product content. This not only deepens the understanding of the molecular mechanism of related biosynthesis, but also lays an important foundation for efficient production of high-value coumarin by using genetic engineering technology.
Owner:JILIN AGRICULTURAL UNIV

An EMC visualization guiding method based on EMC data assets

PendingCN122287547ALower the threshold of understandingreduce overloadGraphicsEngineering
This invention discloses an EMC visualization guidance method based on EMC data assets, belonging to the field of EMC design assistance technology. It includes: identifying the visualization object and obtaining its identification information; retrieving matching quantitative data using the identification as an index, generating a supplementary data request form when data is missing; mapping the quantitative data into expert-style graphical elements to generate a visualization guidance interface, progressively displaying basic physical concepts, coupling paths, three-layer protection, test types, process assets, and decision reporting views; receiving user interaction commands, recording the operation sequence and corresponding visualization status during historical operation sequence playback, forming an operation sequence and status snapshot data asset and assigning multi-dimensional searchable tags; and generating visualization output based on this data asset. This invention transforms abstract EMC data into intuitive graphics, records the key evolution of the design and diagnostic process, supports timeline playback, analog guidance, and cross-domain reuse, realizing the digital accumulation and efficient reuse of design experience.
Owner:BEIJING GAOBO ELECTROMAGNETIC COMPATIBILITY TECHNOLOGY CO LTD

Corn ZmMORF3 gene, excellent haplotype thereof and application of corn ZmMORF3 gene in grain development regulation and molecular breeding

The invention discloses a corn ZmMORF3 gene, an excellent haplotype of the corn ZmMORF3 gene and application of the corn ZmMORF3 gene in grain development regulation and molecular breeding. A key gene ZmMORF3 which affects mitochondrial gene RNA editing is cloned by using a grain mutant m497 found in a corn field breeding line selection process, and the gene encodes MORF protein and regulates assembly and activity of a mitochondrial compound I, so that corn grain development is affected; the excellent allelic variation genotype of the ZmMORF3 gene in the aspect of the row grain number is further excavated, and the row grain number can be increased by utilizing the ZmMORF3 gene, so that the yield is increased. In addition, distribution and utilization potentials of different haplotypes in a selfing line are researched, and technical support and excellent germplasm resources are provided for utilization of the gene.
Owner:HENAN AGRICULTURAL UNIVERSITY

A tube bundle convection heat exchange characteristic test experiment system and method based on digital twinning technology

The application provides a kind of pipe bundle convection heat transfer characteristic test experimental system and experimental method based on digital twinborn technology, belongs to pipe bundle convection heat transfer characteristic test field.For solving the problem that students are difficult to intuitively analyze the movement of fluid and heat transfer process in the existing heat transfer experiment teaching, it is difficult to deeply understand the complex relationship between heat transfer and fluid mechanics, and the experimental operation and data acquisition function are not intelligent and efficient enough.A virtual and real digital twinborn experiment system is constructed, the virtual twinborn model is continuously optimized through real-time data interaction, the model accuracy and reliability are improved;Compared with the traditional virtual experiment system, the authenticity and reliability of the application are higher;Temperature, pressure field monitoring function can be realized in the area where sensors are difficult to arrange in the structure of pipe bundle heat exchanger, whether there is overtemperature and overpressure can be found in time;And to a certain extent, the temperature and pressure distribution of the system at future time is calculated, the advanced prediction and early warning function is realized to prevent equipment damage or cause safety accidents.
Owner:HARBIN INST OF TECH AT WEIHAI +1

Brain function connection intelligent screening method and system for autism spectrum disorder

PendingCN121943222AFully portrayedthree-dimensional depictionMedical data miningMental therapiesNetwork modelSpectrum disorder
The invention relates to the technical field of neural image analysis, and particularly provides a brain function connection intelligent screening method and system for autism spectrum disorders, and the method comprises the steps: firstly obtaining resting state functional magnetic resonance imaging data and phenotype information thereof, and extracting a blood oxygen level dependence value time sequence of each brain region after preprocessing; then constructing a multi-scale brain network comprising a low-order function connection matrix and at least one high-order function connection matrix; the matrix is converted into a brain function connection graph containing sub-graphs of different scales through threshold sparsification; meanwhile, phenotype embedding features are extracted from phenotype information; the graph data and the phenotypic features are input into a multi-channel neural network model for parallel processing and fusion, and joint feature representation is obtained; and finally, outputting an auxiliary diagnosis result of the autism spectrum disorder through the classifier. According to the method, by fusing the multi-scale brain function connection information and the individual phenotype features, the accuracy of autism classification diagnosis and the generalization ability of the model are effectively improved.
Owner:SHANDONG WOMENS UNIV

A method for assessing regional climate change ecosystem service loss

This invention discloses a method for assessing ecosystem service losses due to regional climate change. The region includes counties, cities, or important ecological function zones. The steps are as follows: S1. Collect remote sensing data and preprocess the data through band combination, geometric correction, and projection transformation. Select a standard color composite scheme, establish interpretation markers, and perform visual interpretation. S2. Calculate and statistically analyze the unit area yield value and equivalent factor of grain crops. The equivalent factor is 1 / 7 of the average market value of grain in the current year. S3. Statistically analyze land use types, calculate the magnitude of land use change, reflecting the changes in the total amount of different land use types and the overall trend of land use type changes. S4. Select vegetation cover as an indicator, and adjust the ecosystem service value based on two parameters: net primary productivity and vegetation cover. This invention is of great significance for formulating ecosystem management strategies under the background of future climate change.
Owner:NANJING FORESTRY UNIV +1

A method, system, storage medium and device for predicting multiple complications of sepsis

The application discloses a kind of sepsis multiple complications prediction method, system, storage medium and equipment, belong to intelligent medical technical field, method includes the following steps: S1. acquisition sepsis patient multidimensional time series physiological data;S2. medical perception feature vector is constructed to the time series physiological data;S3. sepsis multiple complications prediction model is constructed and introduced physiological logic space-time composite mask matrix;S4. the output multiple complications prediction probability using hierarchical expert hybrid network H-MoE;S5. the model is trained using dynamic weighted loss function based on task uncertainty;S6. risk output and feature contribution degree explanation;The model of the application is introduced by physiological logic mask and H-MoE architecture, realizes the accurate, synchronous prediction of sepsis complex complications, can effectively filter redundant features, and reveal the complex correlation therebetween, provide quantitative decision support for clinician, to realize early intervention and individualized treatment.
Owner:SOUTHWEST PETROLEUM UNIV

The constraint conversion device and the demonstration teaching aid for constructing the influence lines of a multi-span statically determinate beam using the kinematic method

ActiveCN118098054BEnhance interestincrease engagementEducational modelsInfluence lineClassical mechanics
This invention discloses a constraint conversion device and a demonstration teaching aid for constructing the influence line of a multi-span statically determinate beam using the kinematic method. The device includes: a first connecting member for connecting and fixing a first rigid member; a second connecting member for connecting and fixing a second rigid member; several shear constraint conversion boxes of the same shape, height, and proportionally varying length and width, with adjacent shear constraint conversion boxes nested together to form a retractable shear constraint conversion box group; each shear constraint conversion box has a first pin hole, and after all shear constraint conversion boxes are nested and overlapped, all the first pin holes can be fixed by a first pin shaft; and a hinge constraint conversion track, one end of which is fixedly connected to the first connecting member, and the other end of which is hinged or fixedly connected to the shear constraint conversion box group. Advantages: This invention allows switching between shear constraints and hinge constraints; it allows students to assemble the required structural form and release the corresponding constraints, intuitively displaying the structural motion form and deepening students' understanding of the mechanism's motion mode under external forces.
Owner:HOHAI UNIV

Distributed finite-time synchronization method for multi-layer heterogeneous networks with containment impulse control

The application provides a kind of distributed finite time synchronization method of multi-layer heterogeneous network of restraining pulse control, and relates to the field of control and information technology.The application combines distributed restraining control and pulse control to realize the finite time synchronization of multi-layer heterogeneous network.On the one hand, the method of distributed control can reduce the dependence on global information of network and improve the robust performance of controller. On the other hand, the discontinuous characteristics of pulse control can reduce the control cost while achieving control effect. Based on Lyapunov stability theory, sufficient conditions for network to achieve finite time synchronization are obtained. Compared with homogeneous network, the heterogeneous network model can better describe the state of each node in the network. Analyzing the heterogeneous network is conducive to deepening the understanding of complex network synchronization control, and has profound theoretical value and rich practical value.
Owner:NORTHEASTERN UNIV AT QINHUANGDAO

A transformer operating state monitoring method and system

PendingCN122506439Adeepen understandingensure safety
This invention relates to a method and system for monitoring the operating status of a transformer. The steps include: real-time monitoring and acquisition of key operating data of the transformer; preprocessing the key operating data; extracting key features from the preprocessed key operating data; constructing multivariate time series data; reconstructing the phase space using time delay embedding technology; constructing a chaotic attractor from the time series data; and conducting in-depth analysis of the morphology and dynamic evolution of the chaotic attractor through topological data analysis to identify abnormal states of the transformer. This invention, by introducing chaotic attractors and topological analysis, not only deepens the understanding of the complex behavior of transformers but also enables quantitative analysis of these behaviors to accurately identify abnormal states and provide early warnings before faults occur, thereby ensuring the safety and reliability of transformer operation.
Owner:JIANGXI LICI ELECTRONICS CO LTD

A side-chain modified non-fullerene acceptor material and its application in ternary planar heterojunction organic solar cells

PendingCN122080029AImprove device efficiencyComprehensive performance optimization capabilitiesOrganic chemistryPhotovoltaic energy generationOrganic solar cellPhoton capture
This invention discloses a side-chain modified non-fullerene acceptor material and its application in ternary planar heterojunction organic solar cells, relating to the field of organic optoelectronic materials and devices. The side-chain modified non-fullerene acceptor material is designed and synthesized through a side-chain engineering strategy and can be used as a third component in ternary planar heterojunction organic solar cells. This material is highly compatible with classical planar heterojunction systems (such as PM6 / Y6). By adding it to either the donor or acceptor phase, the interfacial energy levels of the active layer can be finely controlled, and the vertical alignment and crystallinity of molecules can be optimized, thereby synergistically improving the photon capture efficiency and charge transport performance of the device. This invention provides an effective material strategy for resolving the contradiction between photon capture and charge transport in planar heterojunction devices, offering a new approach for developing high-efficiency, low-energy-loss ternary organic solar cells.
Owner:BEIJING UNIV OF POSTS & TELECOMM

Quantized energy level measuring device based on surface photovoltage and measuring method

ActiveCN117388656Bdeepen understandingImprove practical ability
This invention discloses a device and method for measuring quantum energy levels based on surface photovoltage. The device includes: a tunable wavelength monochromatic light source module, a signal generation and modulation module, and a signal receiving and detection module. The tunable wavelength monochromatic light source module is used to convert polychromatic divergent light into monochromatic light with a tunable wavelength. The signal generation and modulation module is used for quantum energy level measurement, spin energy level measurement, and quantum energy level modulation in atmospheric or vacuum environments. The signal receiving and detection module is used to receive the photovoltage signal of the sample and obtain the dependence of photovoltage on wavelength. The device has advantages such as low cost, easy partial replacement and maintenance, and convenient functional expansion.
Owner:XIAMEN UNIV

A method for resolving two-dimensional cube stacking diagrams into three dimensions

ActiveCN116188672BImplement parsingdeepen understanding3D modelling
This invention relates to a method for parsing a two-dimensional cube stacking diagram into a three-dimensional one, in the field of image recognition technology, comprising the following steps: S1: collecting data of the cube stacking diagram using an automated data acquisition module, forming a dataset and automatically creating a label file; S2: training a geometric target recognition module based on a BlockNet network using the dataset; S3: photographing the cube stacking diagram to be parsed, and using the trained geometric target recognition module to parse the geometric structure of the cube stacking; S4: sending the parsed geometric structure to an AR device for dynamic display.
Owner:CHONGQING UNIV

OsWRKY30, a gene for resistance to southern rice black-streaked dwarf disease, and its application.

PendingCN122080156AEnhance antiviral defense responsePromote biosynthesisMicrobiological testing/measurementPlant peptidesBiotechnologyDisease
This invention discloses a gene for rice resistance to Southern Rice Black-Streaked Dwarf Disease. OsWRKY30 Its application belongs to the fields of plant genetic engineering and molecular breeding technology. OsWRKY30 The gene encodes a WRKY family transcription factor, the nucleotide sequence of which is shown in SEQ ID NO:1, and the amino acid sequence of which is shown in SEQ ID NO:2. Experiments showed that knocking out this gene significantly reduced rice resistance to SRBSDV and exacerbated disease symptoms. This gene enhances rice's antiviral defense by positively regulating jasmonic acid biosynthesis and signaling pathways and activating the expression of a series of downstream disease resistance-related genes. Furthermore, in resistant and susceptible varieties... OsWRKY30 Natural variations associated with resistance were discovered in the promoter region, which can be used as molecular markers for disease resistance breeding. This invention provides important genetic resources and molecular tools for breeding new rice varieties resistant to SRBSDV.
Owner:GUANGXI ZHUANG AUTONOMOUS REGION ACAD OF AGRI SCI

Monoclonal antibody of porcine rotavirus VP6 protein, its epitope and application

ActiveCN121517516BClear and specific fluorescent signalDemonstrated ability to recognize native antigensSerodiagnosesLinear epitope
The application discloses a monoclonal antibody of a porcine rotavirus VP6 protein, an epitope of the monoclonal antibody and application of the monoclonal antibody. The monoclonal antibody can specifically recognize a linear B cell epitope on the VP6 protein, and a core sequence of the epitope is TTRLSFQLVR. The antibody has high affinity and high specificity, and can cross-react with porcine rotaviruses of various genotypes such as G5, G9 and G11. The application further includes an indirect ELISA detection kit containing the monoclonal antibody, and application of the linear epitope in detection of porcine rotaviruses, development of vaccines and research on functions of viral proteins. The application provides an important tool and theoretical basis for serological diagnosis, vaccine evaluation and etiological research of porcine rotaviruses.
Owner:JIANGXI AGRICULTURAL UNIVERSITY

Intelligent auditing system for environmental assessment report based on dynamic classification and knowledge mapping

The invention relates to the technical field of environmental assessment text processing, and discloses an intelligent auditing system for an environmental assessment report based on dynamic classification and knowledge mapping, which enables a classification system to automatically identify a novel pollution type and dynamically adjust a type boundary through multi-source data fusion and an incremental learning algorithm. The method ensures that the classification result always meets the newest environmental policy requirement, and ensures that the knowledge base can synchronize the newest standard specification content in real time by establishing a classification system and a trigger updating mechanism of the standard specification, thereby achieving the effect of comprehensively improving the professionalism and timeliness of the environmental assessment system. The system can automatically adapt to environmental policy changes and technical standard updating, can maintain scientificity of a classification system and integrity of a knowledge base without manual intervention, ensures that newest and most relevant standard specifications can be called for professional judgment when various environmental assessment reports are audited, and remarkably reduces audit deviation caused by knowledge lag.
Owner:NANTONG ZHONGQI ENVIRONMENT TECH CO LTD +1

Animal individual health monitoring system based on real-time data

PendingCN121964146Adeepen understandingimprove welfarePhysical therapies and activitiesMedical data miningData streamData acquisition
The invention relates to the technical field of animal health monitoring, and discloses an animal individual health monitoring system based on real-time data. According to the system physiological data acquisition assembly, vital sign original data flow of an animal individual is synchronously obtained through an implantable biosensor and a non-contact optical sensor, and the data flow comprises a cortex temperature change curve, a microcirculation blood flow frequency spectrum and a three-dimensional motion acceleration sequence; the multi-modal fusion analysis component is used for carrying out space-time alignment and feature level fusion processing on the original data stream to generate a comprehensive physiological state map; the health state evaluation component is used for performing multi-scale pattern recognition on the atlas by adopting a deep neural network model and outputting a health risk probability value and a potential pathological region mark; the dynamic self-adaptive compensation component is used for carrying out individualized calibration on the risk probability value according to the animal variety physiological constant database; and the real-time feedback execution component is used for generating a health intervention instruction set based on the pathological region marks.
Owner:QINGDAO ZHONGDAO INTELLIGENT TECHNOLOGY CO LTD

Anisotropy testing and analysis device and method for soil fabric of non-homogeneous soil

ActiveCN116908012BRealize monitoringdeepen understanding
The application discloses a device for testing and analyzing anisotropy of non-homogeneous soil structure, which comprises a multi-dimensional elastic wave testing device, a multi-dimensional image acquisition and analysis system, a wave signal interpretation and processing system and a graded loading model box. The device can be used for measuring the anisotropy degree of non-homogeneous soil structure under different load conditions and different soil characteristics. The multi-dimensional elastic wave testing device is used for measuring the shear wave velocity and compression wave velocity of non-homogeneous soil in different directions. The multi-dimensional image acquisition and analysis system is used for analyzing the structure characteristics of non-homogeneous soil in the microscopic scale on the elastic wave propagation path. The wave signal interpretation and processing system is used for determining the shear wave velocity, compression wave velocity and anisotropy degree of non-homogeneous soil. The graded loading model box comprises a single-face opening transparent model box and a graded weight loading device. The application can realize the multi-scale macroscopic and microscopic observation and characterization of soil structure, and construct the quantitative relationship between the microscopic parameters and the macroscopic characterization parameters of the structure.
Owner:HOHAI UNIV

In-situ additive manufacturing method and system for high-temperature and high-pressure limited space in shaft

The invention relates to the technical field of crossing of oil and gas well engineering and additive manufacturing, in particular to an in-situ additive manufacturing method and system for a high-temperature and high-pressure limited space in a shaft, and the in-situ additive manufacturing method and system for the high-temperature and high-pressure limited space in the shaft are characterized in that S1, the in-situ additive manufacturing system for the high-temperature and high-pressure limited space in the shaft is lowered to a designated repair area in the shaft through a coiled tubing; s2, a local high-pressure environment protected by inert gas is established through an environment isolation module, and conversion from a dynamic shaft fluid environment to a static controllable gas environment is achieved; s3, based on a micro heat source and a multi-degree-of-freedom mechanical arm, a precise feeding mechanism is matched, and metal material cladding is conducted layer by layer in the repair area according to a preset path; s4, the molten pool state is fed back in real time through an online monitoring system of a molten pool camera and an infrared thermometer, technological parameters are dynamically adjusted, and high-quality metallurgical bonding under closed-loop control is achieved; and S5, after the structure is repaired, surface remelting and online quality screening are conducted on the repaired area, and in-situ repairing of the shaft is achieved.
Owner:HARBIN INST OF TECH

Application of nuciferine in preparation of medicine for relieving pyroptosis of trophoblasts in preeclampsia

PendingCN121754547AImprove growth restrictionfunction increaseOrganic active ingredientsUrinary disorderFetal growthCaspase
The invention belongs to the technical field of biology, and particularly relates to application of nuciferine in preparation of a medicine for relieving pyroptosis of trophoblasts in preeclampsia. Nuciferine inhibits activation of NLRP3 inflammasomes and reduces caspase-1 cleavage and GSDMD mediated pyroptosis, so that placenta inflammation and dysfunction are relieved, and preeclampsia symptoms are improved. The nuciferine remarkably improves the symptoms of fetal growth limitation and placenta weight reduction of preeclampsia mice, and reduces placenta oxidative stress and inflammation level. In a cell model, nuciferine effectively reverses the pyroptosis phenotype of trophoblast cells, and the protein expression of NLRP3, cleaved-caspase-1, GSDMD-NT and IL-1beta is remarkably reduced. The application potential of nuciferine as a promising natural medicine in preeclampsia treatment is clarified, and the understanding of the relationship between inflammation and pyroptosis in preeclampsia pathogenesis is deepened.
Owner:MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV

Application of CCNB1 phosphorylation inhibition tool in preparation of medicine for preventing and / or treating triple negative breast cancer

PendingCN121868489AClear mechanismStrong targetingPeptide/protein ingredientsBiological testingProtein phosphorylationTargeted therapy
The invention discloses application of a CCNB1 phosphorylation inhibition tool in preparation of a medicine for preventing and / or treating triple negative breast cancer, and particularly relates to application of a CCNB1 protein S128 site phosphorylation inhibitor in preparation of a medicine for preventing and / or treating triple negative breast cancer. The phosphorylation inhibitor refers to a tool or means used in the process of blocking or weakening protein phosphorylation, particularly a gene editing system, and the 128 serine Ser coded by a CCNB1 gene is mutated into alanine Ala which is recorded as S128A in a target cell. Compared with a traditional small molecule drug, the gene editing tool accurately intervenes phosphorylation modification at the gene level, has the advantages of being clear in mechanism, high in targeting performance, high in safety and the like, is suitable for basic research and potential clinical transformation of TNBC targeted therapy, and has a good application prospect.
Owner:ZHEJIANG UNIV OF TECH

A Cross-Platform Public Opinion Dynamic Assessment Method and System Based on Real-Time Semantic Awareness

PendingCN122087332AResolve aggregationSolve the shortcomings of non-convergenceDatabase updatingDatabase management systemsOpinion analysisOpinion dynamics
This invention discloses a cross-platform dynamic evaluation method and system for public opinion based on real-time semantic perception, belonging to the field of online public opinion data processing. The method includes the following steps: collecting multi-platform, multi-modal, heterogeneous data; standardizing the data; semantically aggregating the standardized cross-platform multi-modal data corresponding to each propagation event based on an event semantic center vector model; iteratively updating the event semantic center vector through online exponential sliding updates to address the dynamic evolution of propagation events, continuously supplementing the event semantic center vector with newly added standardized data related to the propagation event in real time; quantitatively evaluating the comprehensive performance of each propagation event on different platforms based on a platform performance index model, and constructing a cross-platform content ranking based on the comprehensive performance using a multi-attribute normalized decision function; and intuitively presenting the cross-platform online public opinion analysis results using a three-level responsive visualization view.
Owner:COMMUNICATION UNIVERSITY OF CHINA

A MEC nanoprobe, its preparation method and application

ActiveCN121550424BEquipped with dual-modal imaging performancedeepen understandingOrganic active ingredientsPowder deliveryAcetic acidCentrifugation
This invention discloses a MEC nanoprobe, its preparation method, and its applications. The MEC nanoprobe is composed of Mn... 3+ The sample was prepared using TCPP, Erastin, and CD133mab, with CD133mab coupled to the surface. The preparation method involved adding Mn... 3+ Mn-TCPP-MOF was synthesized by stirring TCPP in an N,N-dimethylformamide solution containing acetic acid; Erastin was then added and stirred at room temperature, followed by centrifugation, washing, and redispersing in deionized water; the amide bonds were then activated via EDC / NHS and coupled to CD133mAb to obtain MEC nanoprobes. The combined application of this MEC nanoprobe with a TGFβ1R inhibitor can block both the classical ferroptosis resistance pathway and CAF-related pathways, achieving dual-channel blockade of ferroptosis resistance in pancreatic cancer. Furthermore, dual-modal imaging enables semi-quantitative in vivo visualization assessment of ferroptosis resistance, demonstrating promising clinical application prospects.
Owner:THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIV +2

A cognitive diagnosis and reverse thinking training education system based on dual AI collaboration

ActiveCN121581820BAvoid the limitations of "one size fits all"high acceptanceOffice automationKnowledge based modelsFeature vectorMultimodal data
This invention relates to a cognitive diagnosis and reverse thinking training education system based on dual AI collaboration, belonging to the fields of educational technology and artificial intelligence technology. The system includes: acquiring and preprocessing multimodal data from students' learning process, outputting multidimensional cognitive feature vectors; dynamically dividing cognitive levels based on these vectors, constructing differentiated cognitive profiles, and generating personalized training task matrices by combining them with a mapping rule base; locating cognitive gaps and logical error paradigms, calling a metacognitive question chain library to generate a progressive question sequence, and combining it with scenario-based verification tasks to form a set of error correction and knowledge reinforcement; constructing a pre-construction common difficulty training module for a group cognitive graph, building a dynamic mastery assessment index system, and generating multidimensional ability feedback reports. This achieves accurate diagnosis of students' cognitive states and personalized training adaptation, efficiently repairing knowledge gaps, strengthening reverse thinking abilities, and improving the pertinence and effectiveness of learning and training.
Owner:SHANGHAI FANGLUEMENKOU EDUCATION TECH CO LTD

Mathematics teaching aid capable of reflecting spatial straight line position relation

The utility model discloses a mathematics teaching aid reflecting spatial linear position relation, which comprises connecting columns, connecting sockets, irradiation lamps, reflecting lenses and adjusting assemblies, the 12 connecting columns are assembled to form a cubic frame, the number of the connecting sockets is 8, and the connecting sockets are correspondingly distributed at the 8 vertexes of the cubic frame to connect the connecting columns. The illuminating lamp is arranged in the connecting column, the reflecting lens is arranged in the connecting socket to reflect illuminating light, and the adjusting assembly is arranged in the connecting socket and connected with the reflecting lens to drive the reflecting lens to rotate. According to the utility model, the connecting column and the connecting socket are assembled to form the cubic frame, the irradiation lamp is arranged in the cubic frame to reflect the position relation of straight lines in the space, the reflecting lens is arranged in the connecting socket to reflect irradiated light, and the adjusting assembly can drive the reflecting lens to rotate so as to adjust the angle of reflected light.
Owner:CHANGZHOU HIGHER VOCATIONAL TECH SCHOOL OF TOURISM & COMMERCE

A method for three-dimensional visualization of space charge transfer based on in-situ photo-assisted xps

PendingCN122171599AEfficient flow directionHighly efficient reaction siteMaterial analysis using wave/particle radiationHeterojunctionDevice material
This invention discloses a three-dimensional visualization analysis method for space charge transfer based on in-situ light-assisted XPS, belonging to the fields of energy materials technology and material surface analysis methods. The method comprises the following steps: First, an FTO / WO3@Au device material is prepared as the research object. This material has a heterojunction structure between stacked interfaces. Noble metal doping can improve the charge transfer efficiency. Through the plasma effect and electronic mediation of Au, a highly efficient synergistic path from light absorption, charge separation to surface reaction is constructed. Etching is performed on the FTO / WO3@Au surface, so that different layers yield peak intensities of different strengths under XPS spectral analysis. Under XPS spectral imaging, a series of spectra at binding energies are obtained by sampling every 0.1 eV. The data is output in a data table, and then a 3D view is plotted using the best fit formula, which visualizes the charge transfer process and intuitively shows the transfer path of photogenerated charge.
Owner:ZHENGZHOU UNIV

Construction method of colorectal cancer prognosis model based on M7G modification

PendingCN121768680Adeepen understandingMedical simulationMedical data miningPatient stratificationImmunologic function
The invention belongs to the technical field of gene technology and biomedicine, and provides a construction method of a colorectal cancer prognosis model based on M7G modification, which comprises the following steps: firstly, acquiring and downloading the miRNA expression quantity of METTL1 and cofactors WDR4 thereof of 539 tumor samples and 9 normal samples from a TCGA database, and then analyzing differential genes between the tumor samples and the normal samples by using an edgeR packet, then selecting 20 miRNAs before the top according to a difference multiple, and drawing a heat map and a volcano map by using a pheatmap and a gplo2 packet so as to present different expression modes of the 20 genes; the colorectal cancer prognosis model consisting of 13 M7G modification related miRNAs is established, can be used as a prognosis evaluation index, and has potential values of helping patients to layer and formulate personalized treatment strategies; and meanwhile, the M7G modification has potential influence on immune cell subset infiltration and immune function in the tumor microenvironment, which is possibly beneficial to deepening the understanding of people on the colorectal cancer tumor microenvironment and brings new hope for the development of immunotherapy intervention in the future.
Owner:NANCHANG UNIV