This invention belongs to the field of acute
lymphoblastic leukemia (ALL) diagnosis and treatment technology, and discloses an ALL
scoring system. The feature
library construction module establishes an associated feature
system based on subtype molecular biological differences, uses
LASSO regression and subtype stratified analysis to screen core features and determine weights, and excludes redundant cross-subtype information. The
feature mining module targets the entire treatment cycle, dividing the collection nodes into induction, consolidation, and maintenance phases, capturing
temporal correlation features such as the rate of MRD decline and
gene expression change rate, breaking the limitation of relying solely on
static data at the time of diagnosis. It not only fits the individual characteristics of patients with different subtypes, but also reflects the dynamic changes in the treatment process, improving the accuracy of prognostic assessment. A real-time corrected
score is obtained by calculating the baseline
score and the temporal feature adjustment
score.
Patient data is updated weekly through the
electronic medical record interface, and appropriate solutions are output for different situations such as low-risk, intermediate-risk, and very high-risk.