3235results about How to "Promote accumulation" patented technology

Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012–1×1013 vector genomes / ml.

Only when a wall side and the vicinity of an obstacle are cleaned, a side brush is operated and the cleaning is carried out, and when any other place than the wall side and the vicinity of the obstacle is cleaned, the side brush is maintained in a stoppage state. When a place such as the wall side or the vicinity of the obstacle in which dust is easy to accumulate is cleaned, the side brush is operated to enhance the dust collecting property. When any other place than the wall side or the vicinity of the obstacle is cleaned, the side brush is stopped to suppress power consumption and generation of a noise. A judgment processing portion detects based on a detection signal from an obstacle detecting portion that a cleaner is approaching a wall or an obstacle. In response to such detection, the judgment processing portion instructs a travel steering portion to carry out immediate rotation and change of a travel direction, or travel along a wall side. Also, the judgment processing portion instructs a side brush driving portion to drive a side brush only in the rotation and in the wall side travel, and to stop the side brush in straight advance travel.

In a biometrics system for a building entrance unlocking or a bank account authentication, reference information registered under administration by the system is transmitted to a room or mobile-phone for private storage, with the original reference information deleted from the system. Biologic information gotten upon authentication is transmitted through wireless system to the room or mobile-phone for comparison with the reference, the result being returned to the system. Or, the reference is tentatively sent back to the system for comparison with the gotten biologic information. The biologic information sent to mobile-phone also includes health control information for storage and display. Mobile-phone also can receive blood pressure information at a waiting lounge of medical institution though wireless local communication even if the main power shut down. The communication between the biometrics system and the mobile-phone is encrypted. The system includes sensor unit and protection unit, the abnormality thereof being separately checked.

The present invention relates to a numerical control machine tool digital twinning modeling method. A physical space, a digital twinning digital space and a digital twinning mapping model are provided. The digital twinning digital space is connected with the physical space through the digital twinning mapping model; a data sensor is installed on a numerical control machine tool, the data sensor isconnected with a numerical control system through different data interfaces, the numerical control system performs related data collection and protocol analysis through the digital twinning mapping model; the digital twinning digital space comprises a digital twinning description model and a digital twinning intelligent model, and the digital twinning intelligent model achieves intelligent service of numerical control machine tool digital twinning through data analysis and decision. The modeling method employs multi-field uniform modeling language Modelica to allow the established digital twinning description model to have features of multi-field uniform modeling, mathematics equations and object-orientation, and can more really reflect the constitutive relation of a complex dynamo-electric system.

A method for forming a prograde kinematic model allowing reproduction in 3D intermediate geometries of geologic objects of an underground zone such as a sedimentary basin, from an initial state to a current state. A representation of the current geometry of the geologic objects of the zone is formed by interpretation of acquired data obtained by seismic exploration, by in-situ measurements and by observations, then each geologic object is subdivided into layers separated by deformation interfaces. Each one of the layers is defined by means of a grid pattern into a series of hexahedral volume elements. Tectonic deformations are then applied separately and successively to each series of volume elements of a layer in relation to an underlying layer while conserving the thickness and the surface area of an intermediate neutral surface in each volume element. Then the tectonic deformations are iteratively modified until a geologic representation substantially in accordance with the known final state of the underground zone is obtained.

A system and method that translates sentences of natural language text into sets of axioms of formal logic that are consistent with parses resulting from NLP and acquired constraints as they accumulate. The system and method further present these axioms so as to facilitate further disambiguation of such sentences and produces axioms of formal logic suitable for processing by automated reasoning technologies, such as first-order or description logic suitable for processing by various reasoning algorithms, such as logic programs, inference engines, theorem provers, and rule-based systems.

Nanotubular structured titanium (Ti) substrates have been coated with nanoparticulate hydroxyapatite (nano-HA). The nano-HA surface is highly adherent to the nanotubular Ti surface and is free of microparticles. The nano-HA coated nanotubular Ti surface promotes osteoblast cell adhesion and is particularly suitable for orthopedic and dental implants where deposition of osteoblasts and other proteins is important in bone formation.

Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012−1×1013 vector genomes / ml.

The invention discloses a compound microorganism liquid bacterial fertilizer for preventing plant diseases and insect pests and a preparation method of the compound microorganism liquid bacterial fertilizer and belongs to the technical field of microorganisms. The bacterial fertilizer comprises raw materials of, by weight, 10-20 parts of paprika powders, 10-20 parts of chilli powders, 5-15 parts of ginkgo leaf powders, 5-15 parts of chinaberry powders, 5-15 parts of lightyellow sophora root powders, 20-40 parts of mashed garlic, 40-80 parts of molasses, 4-8 parts of soybean meal, 5-15 parts of calcium sulfate, 5-15 parts of magnesium chloride, 5-10 parts of salt, 5-15 parts of photosynthetic bacterium strains, 5-15 parts of saccharomycete strains, 5-15 parts of lactic acid bacterium strains, 5-15 parts of streptomyces jingyangensis strains, 5-15 parts of bacillus subtilis strains and 800 parts of water. According to the compound microorganism liquid bacterial fertilizer, probiotic floras which are screened and are capable of coexisting are used for fermenting plant leaching agents of pepper, chilli, ginkgo leaves, chinaberry, lightyellow sophora roots and garlic, the plant leaching agents are capable of expelling and killing the insect pests and harmful bacteria, the compound microorganism liquid bacterial fertilizer has the advantages of being high in content of live bacteria of probiotics, high in activities, high in stability, small in using amount of plant materials, fast in acting effects, non-toxic and environment-friendly, and has wide application prospects in agricultural planting.

The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Based on our identification of a polypeptide (Angiopep-7) that is efficiently transported to cells such as liver, lung, kidney, spleen, and muscle, the invention provides polypeptides, conjugates including the polypeptides, and methods for treating diseases associated with these cell types. Unlike other aprotinin related polypeptides identified herein (including Angiopep-3, Angiopep-4a Angiopep-4b Angiopep-5, and Angiopep-6) which efficiently cross the blood-brain barrier (BBB), Angiopep-7 is not efficiently transported across the BBB.

A hollow fiber membrane module comprising a large number of hollow fiber membranes contained in a cylindrical case, wherein one end of each hollow fiber membrane, which is left open, is fixed to the cylindrical case, while the other ends of the hollow fiber membranes are divided into more than one small bundles, with the ends, contained in separate small bundles, being kept together and plugged.

The invention discloses traditional Chinese medicine organic fertilizer. The traditional Chinese medicine organic fertilizer comprises sweet wormwood herb, green Chinese onion, sophora flavescens, yellow soybean, salvia miltiorrhiza, perilla stem, castor root or castor leaf, salvinia natans, onion, peach leaf, camphor, tripterygium wilfordii, agaric, pine needle, plantain seed, lime, honeysuckle, frankincense, Chinaberry bark, Chinese yam, potash, carrot leaf, radish leaf, poria cocos, pyrethrum, belvedere fruit, pseudo-ginseng, negundo chastetree fruit, mulberry leaf, hot pepper leaf, ginger leaf, phoenix tree flower, tobacco, pepper and suberect spatholobus stem. The fertilizer can improve the soil structure, so that the soil is abundant in organic matters and soil hardening caused by excessive using amount of chemical fertilizer is avoided; a good effect of increasing yield is achieved; the fertilizer can expel, kill and prevent insects, reduces the using amount of pesticide or does not use the pesticide, contributes to environmental protection, and reduces the pesticide residue of agricultural products or has no pesticide residue in the agricultural products; the fertilizer can inhibit generation and growth of harmful germs and reduce the number of the harmful germs so as to reduce the morbidity of crops and solve the problem of continuous cropping; and the cost is low.

The invention discloses a method for cultivating tea comprising the steps of, tea plantation sun screening, planting deciduous arbor around the tea plantation and between the tea trees, covering the tea plantation through rice straw and planting bean green manure, applying special-purpose fertilizer for organic tea, inoculating beneficial soil organisms and soil creatures including right amount of earthworm, finally carrying out irrigation through mini- sprinkling irrigation system in high temperature dry seasons.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.

The present invention provides innovative methods and techniques for improving seedling germination and plant establishment within wildland and forested ecosystems, cultivated systems, urbanized areas, and areas impacted by wildfire. The invention comprises novel seed coating methods for applying wetting agents (or surfactants), tackifiers, and other beneficial soil and plant amendments, to single seeds or agglomerates composed of pellets containing multiple seeds. The invention can be used to: 1) ameliorate soil water repellency for increasing soil moisture availability; 2) bind seeds to the soil surface in order to prevent loss from wind and water erosion; 3) provide seedlings necessary leverage required for root penetration; 4) improve seedling emergence, by having several cotyledons associated with an agglomerate collectively generate sufficient force to penetrate the soil surface, with particular utility for seedlings impaired by a soil physical crust; and 5) minimize impacts from disturbance by increasing seedling stability.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention relates to preparation method and application method of a grape special fertilizer, wherein the preparation method comprises the following steps: preparing an I-type fertilizer by taking the following ingredients in parts by weight: 30-40 parts of urea, 20-30 parts ammonium phosphate, 15-30 parts of potassium sulphate, 1-3 parts of humic acid, 1-3 parts of excrement, 1-5 parts of synergist, 0.1-1.0 part of ferrous sulphate, 0.1-0.8 part of zinc sulfate, 0.1-0.6 part of manganese sulphate, 0.1-0.6 part of borax, 0.1-0.4 part of copper sulfate, 3-7 parts of plaster and 3-13 parts of bentonite; preparing an II-type fertilizer by taking the following ingredients in parts by weight: 7-15 parts of urea, 25-35 parts ammonium phosphate, 35-45 parts of potassium sulphate, 1-3 parts of humic acid, 1-5 parts of excrement, 2-5 parts of synergist, 0.1-1.0 part of ferrous sulphate, 0.1-0.8 part of zinc sulfate, 0.1-0.6 part of manganese sulphate, 0.1-0.6 part of borax, 0.1-0.4 part of copper sulfate, 3-7 parts of plaster and 3-13 parts of bentonite; and blending, spraying, pelleting and drying at lower temperature to obtain the product. The application method of the fertilizer comprises the following steps: taking an organic fertilizer and the II-type fertilizer as a base fertilizer; applying the I-type fertilizer before blossom, applying the II-type fertilizer in the young fruit development period, and meanwhile, respectively spraying monopotassium phosphate and rare earth mixed liquid once on the leaf surfaces; and spraying calcium nitrate or calcium acetate to enhance the storage resistance property before picking.

A sliding surface of at least one of sliding members sliding with respect to each other in a sliding direction comprises a protrusion extending along a direction intersecting the sliding direction and fine dimples provided on a surface of the protrusion. In the sliding members, lubricating oil is accumulated in the dimples, and is easily extracted through a drain portion formed by dimple in a running-in operation.

A shot-blasting installation (1) for blasting work pieces (30) made from light metal alloys, comprising at least one blasting chamber (3) for receiving the work pieces that are to be blasted, at least two blasting wheels (6) arranged in walls of the blasting chamber for introducing a blasting agent into the blasting chamber, and a separator (8) for separating the mixture of blasting agent and material that has been removed by blasting, wherein the separator (8) is arranged directly beneath the blasting chamber (3), and wherein a manipulator (10) for handling the cast work piece (30) during blasting is arranged in the blasting chamber (3).

A two-step targeted tumor therapeutic method is described comprising nanocarrier with prodrug encapsulated thereto and prodrug activating enzyme. The enzyme is either encapsulated in nanocarrier, or not encapsulated, or synthesized in the tumor. With the method, the prodrug released from the nanocarrier is activated by the enzyme mainly in the tumor.

The invention discloses a cathode material of a lithium ion battery, a preparation method of the cathode, and the lithium ion battery using the cathode material, belonging to the technical field of energy material. According to the invention, a chemical dispersant is added into the cathode of an aqueous lithium-ion battery, thereby solving problems of uniform dispersion for active materials of positive electrode and a nano-carbon mixed conductive agent; and a mechanical dispersion method is combined, preferably with a revolution speed of the mechanical dispersion being 15-35 HZ and a rotation speed being 10-30 HZ, thereby realizing uniform dispersion of the nano-active substances in a relatively short time. The cathode material of a lithium ion battery and the preparation method provide technical approach for solving uniform dispersion of the aqueous nano-active substances, and are high in production efficiency and low in cost; the prepared battery is high in discharge capacity, and is significantly improved in low temperature, multiplying power and cycling performances; and a new approach is provided for a large scale application of the nanometer lithium batteries which are limited to a high cost and a high-polluting oil system in the field.

This invention describes a novel method of producing bioactive recombinant proteins from plants. General methods of designing and engineering plants for expression and production of such proteins are also disclosed. Methods for the expression of Transforming Growth Factor-β (TGF-β) proteins, such as Müllerian Inhibiting Substance (MIS), in plants, and methods of producing recombinant proteins from plants are specifically disclosed. Furthermore, the present invention provides methodology for the direct expression and production of a bioactive C-terminal fragment of a TGF-β protein, such as C-terminal MIS. The new method is more cost-effective than other large-scale expression systems, by eliminating the need for costly cell culture and fermentation manufacturing facilities.

The invention discloses a device for exciting high-speed and large-area ionic wind, which comprises an ionic wind exciting area cylinder body, an inlet and an outlet at two ends. Multiple-stage series needle-ring electrodes are arranged in the cylinder body. The device is characterized in that a needle electrode of a post stage and a ring electrode of a previous stage are combined to form an integral multi-needle ring electrode, and the needle electrode and the ring electrode of the multi-needle ring electrode of each two stages form an electrode spacing; the ring electrodes of the multi-needle ring electrode of each two stages are connected in series with a current-limiting resistor outside the cylinder body through a conductor respectively, and then are connected in parallel with a voltage-dividing capacitor to form a discharge loop; and the voltage-dividing capacitors are mutually connected in series, the voltage-dividing capacitor connected with the ring electrode close to the inlet is connected with a direct-current high voltage source, the voltage-dividing capacitor connected with the ring electrode close to the outlet is grounded, and the ring electrode close to the outlet is not provided with a needle electrode and is grounded directly through a conductor. The device can obtain high-speed and large-area ionic wind, and can be applied in various fields of enhanced heat transfer, micro air pumps, air purification and the like.

The present invention provides a method for modifying a wild type nucleic acid sequence encoding a polypeptide to enhance expression and accumulation of the polypeptide in the host cell by harmonizing synonymous codon usage frequency between the foreign DNA and the host cell DNA. This can be done by substituting codons in the foreign coding sequence with codons of similar usage frequency from the host DNA / RNA which code for the same amino acid. The present invention also provides novel synthetic nucleic acid sequences prepared by the method of the invention.

A vapor chamber includes a plate and a wick structure. The plate is provided therein with a working fluid, and the plate has a heated end and a condensed end. The wick structure comprises a first wick portion adhered to be opposite to the heated end, a second wick portion overlapping on the first wick portion, and a third wick portion adhered on the rest portion of a chamber. The aperture diameter of the first wick portion is larger than that of the second wick portion, or the aperture density of the first wick portion is smaller than that of the second wick portion. Therefore, the amount of working fluid attached to the second wick portion is smaller than of the first wick portion. As a result, after heated, the working fluid attached to the second wick portion will be vaporized more quickly, thereby increasing the efficiency of heat transfer and improving the heat-dissipating effect.

The invention relates to a CRISPR / Cas9-based sgRNA design method. The method is characterized by comprising the following steps of obtaining the value of enzyme digestion efficiency of sgRNA and corresponding Cas9; building a personalized sgRNA design model; measuring the quality of the built personalized sgRNA design model by applying an NDCG algorithm and updating a database; and designing sgRNA and giving out an assessment value of each sgRNA. Compared with the prior art, the method has the characteristics of high accuracy, complete characteristics, wide application range and wide data analysis range.