47 results about "Motor nerve" patented technology

The present invention discloses a dyskinesia rehabilitation training method and system based on electroencephalogram signal recognition; the method includes: the convolutional neural network is used to recognize the electroencephalogram signal, analyze the patient's motor intention, convert the motor intention into a control instruction for the exoskeleton device, drive the patient's limb movement by controlling the movement of the exoskeleton device, and assist the patient to complete the movement disorder rehabilitation training. In this method, the self-attention mechanism and self-distillation training were used to establish an electroencephalogram signal recognition model, analyzing the patient's motor intention to help motor nerve remodeling, which broke the passive and single problem of traditional rehabilitation methods, realized active rehabilitation of patients, and significantly improved the rehabilitation efficacy.

The invention belongs to the field of rehabilitation medical treatment, and particularly relates to an intelligent rehabilitation glove system and method based on a noninvasive motor nerve interface, and the method comprises the steps: a wearable electromyographic signal collection unit collects an electromyographic signal at an arm according to a collection instruction sent by a control unit, packages the signals in the same time period, and sends the packaged signals to the control unit; the control unit is used for sending a collection instruction to the wearable electromyographic signal collection unit; meanwhile, the received original electromyographic signals are processed, feature values are obtained, feature vectors are formed, a gesture classifier is trained, the gesture category of the healthy side of the patient is recognized according to the gesture classifier, a motion instruction signal corresponding to the gesture category is output to the flexible pneumatic rehabilitation glove, the gesture identical to the instruction is executed, and then the hand is driven to move. And active rehabilitation training is realized. By optimizing the layout structure, the system is completely integrated on the diseased side arm of the patient, and active and convenient rehabilitation training of various actions of the diseased side hand of the hemiplegic patient is achieved.

The invention belongs to the field of brain-computer interfaces, and particularly relates to a decision-making brain-computer method and device based on virtual reality induction, which combines two psychological decision-making tasks of auditory stimulation and visual stimulation and utilizes virtual reality equipment to create a decision-making brain-computer interface normal form of panoramic interaction, so that a subject can fit a scene facing a decision in reality to the greatest extent, and the accuracy of decision making is improved. The sensory motor cortex is effectively activated, and cooperative activation of the cognitive-motor neural network is induced; a decision interaction feedback link is added to enhance a decision stimulation effect and a cranial nerve feedback mechanism by analyzing related characteristics P300, power spectral density and brain network function connection quantity of the acquired electroencephalogram signals during normal form execution decision reaction. Compared with the prior art, the method has the advantages that immersive audio-visual stimulation and task interaction feedback are brought into a decision-making brain-computer interface for the first time, and a new scheme with neural rehabilitation and human-computer interaction functions is provided for neural feedback training of cognitive functions.

The invention discloses bifidobacterium animalis subsp. Lactis and application thereof in a product for enhancing athletic ability, and relates to the technical field of microorganisms. The invention provides an animal bifidobacterium subsp. Lactis MUS < + >, and the preservation number of the animal bifidobacterium subsp. Lactis MUS < + > is CGMCC (China General Microbiological Culture Collection Center) No.35626. The invention also provides a preparation method of the animal bifidobacterium subsp. Lactis MUS < + >. The animal bifidobacterium subsp. Lactis MUS + provided by the invention can increase the length of surrounding motor nerves and promote the development of the motor nerves; the total exercise distance is increased, and the exercise ability and endurance are promoted; body length or height development is promoted; muscle fibers are thickened, the muscle fiber density is increased, muscle fiber gaps are reduced, and muscle development is promoted; and the method has a very good application prospect in preparation of products for improving athletic ability or increasing muscle.

The present invention discloses a walnut oligopeptide powder with the functions of promoting peripheral nerve regeneration and repairing peripheral nerve injuries and a preparation method thereof, belonging to the technical field of walnut oligopeptide production. The walnut oligopeptide powder uses walnut cake as a raw material, is enzymatically hydrolyzed by an enzyme preparation, and is prepared by fermentation with Kluyveromyces marxianus and Lactobacillus helveticus. The enzyme preparation is trypsin and ficin. Compared with the prior art, the yield of the walnut oligopeptide powder of the present invention is higher. Moreover, it has been proven by experiments that the walnut oligopeptide powder prepared by the present invention can effectively extend the length of peripheral motor nerves and has a good effect on nerve repair.

The invention relates to the technical field of medical monitoring, and particularly discloses an AI anesthesia depth monitoring system combined with nerve stimulation, which is characterized in that standardized electrical stimulation is applied to a motor nerve pathway of a patient in a general anesthesia state, and spinal nerve electrical signals and limb movement signals induced by the standardized electrical stimulation are synchronously acquired and analyzed; performing time-frequency transformation on the neural signal to extract a dominant oscillation mode of the neural signal, and generating a neural rhythm disorder degree characteristic value by quantizing frequency jitter and amplitude attenuation; analyzing the time sequence collaboration of the motion signal and the stimulation and the motion form, and generating a motion response deviation characteristic value; fusing the two features into a two-dimensional feature vector, inputting the two-dimensional feature vector into a pre-trained anesthesia depth classification model, and directly outputting an objective anesthesia depth level; and finally, starting grading early warning according to the grade change trend and generating a monitoring report.

The present invention relates to the field of pharmaceutical chemistry, and provides a quaternary ammonium salt derivative, and a preparation method therefor and a use thereof. The structure of the quaternary ammonium salt derivative is as shown in formula I. The compound of the present invention has an excellent differential blocking effect on sensory and motor nerves, high safety during use, and a long duration of action. Thus, the compound of the present invention has wide application prospects in the preparation of local anesthetic drugs for sensory-motor dissociation.

The utility model relates to a novel bending same-core probe which comprises a probe body and a wire, one end of the probe body is bent, the other end of the probe body is connected with a handle, the probe body comprises a probe tube and a probe core, the wire is arranged in the handle, one end of the wire is respectively connected with the probe tube and the probe core, and the other end of the wire is connected with a connector used for being connected with detection equipment. Heat shrink tubes are arranged on the probe tube and the probe core, insulation is guaranteed while the protection effect is achieved, and the connector and the wire wrap the insulator. The bent concentric probe can detect biological signals in a small range, a special position and a deeper position, the accuracy of biological signal detection is improved, a surgeon is helped to position and map motor nerves through evoked potentials and electromyographic signals, the risk of nerve injury in an operation can be reduced, and therefore better treatment is provided. The product is a disposable medical instrument sterilized by ethylene oxide, so that the phenomenon of infection is effectively prevented.

The embodiment of the application discloses a motor nerve muscle blood vessel coupling function detection system, which comprises a muscle oxygen measurement module, which is covered on a to-be-detected part and is used for acquiring a muscle oxygen signal of the to-be-detected part under a motor stimulation, wherein the muscle of the to-be-detected part is associated with a target motor nerve; a processor, which is used for acquiring state time information; acquiring the muscle oxygen signal of the to-be-detected part under the motor stimulation through the muscle oxygen measurement module; determining a time response characteristic parameter of the muscle oxygen signal based on the state time information; and determining a motor nerve muscle blood vessel coupling analysis result of the to-be-detected part based on the time response characteristic parameter. The motor nerve muscle blood vessel coupling function cannot be used for detecting the motor nerve muscle blood vessel coupling function in the prior art.

To provide a method of treating a paraproteinemic neuropathy in a subject by administering to the subject an antagonist of the complement system.SOLUTION: An antagonist of the complement system inhibits the complement system upstream of complement factor C5. More specifically, the antagonist may be an antibody or an antigen-binding fragment thereof that blocks or inhibits the complement system by inhibiting the C2b domain of complement factor C2. The paraproteinemic neuropathies that may be treated include, in particular, multifocal motor neuropathy (MMN), chronic inflammatory demyelinating polyneuropathy (CIDP), and Guillain-Barre syndrome (GBS).SELECTED DRAWING: Figure 1

A kit for inducing the differentiation of stem cells into motor neural progenitor cells, motor neural precursor cells and / or motor neurons, and the use thereof. The kit uses a culture medium with clear chemical components, small chemical molecules and cytokines, does not involve substances such as animal-derived components that easily cause instability factors such as batch differences, reduces the differentiation period, and can be used in the clinic, thereby making up for the shortcomings of agents used in the existing differentiation methods. The prepared motor neural progenitor cells, motor neural precursor cells and motor neurons have a high purity, are suitable for cell transplantation and the treatment of related diseases, and can be used in the development of clinical products.

Disclosed in the present invention is a method for decoding Chinese character writing for an invasive brain-computer interface. In a practical application, a corresponding motor neural signal is divided into two states of a writing stroke and a writing stroke break in view of inconsistency of the writing stroke and the writing stroke break during Chinese character writing, and different filters are trained. A hidden markov model (HMM algorithm) and a Viterbi algorithm are used to judge a task state of the motor neural signal, and the corresponding signal is put into a corresponding decoder. The present invention effectively reduces influence of difference of neural data in different states on the decoder, and improves the performance and robustness of the decoder.

The invention relates to an amyotrophic lateral sclerosis zebrafish model based on beta-methylamino-L-alanine induction as well as a construction method and application of the amyotrophic lateral sclerosis zebrafish model. According to the method for constructing the amyotrophic lateral sclerosis model by inducing the zebrafish through the BMAA, the non-specific fatality rate in the early stage of modeling is effectively reduced by limiting the initial development node and culture conditions of toxin exposure, and the living animal model with typical motor nerve injury phenotype and good repeatability is obtained. The method is short in construction period and relatively low in experiment cost, can objectively reflect sporadic ALS pathological characteristics induced by environmental factors, and is suitable for being used as an in-vivo biological carrier for high-throughput preliminary screening of anti-ALS drugs and related neurotoxicological researches.

The utility model relates to a leg tapping reaction tester in the technical field of knee jerk reaction detection equipment, comprising a chair and a tapping hammer. A tester sits on the top of the chair and taps his calf with the tapping hammer to perform a knee jerk reaction. Both sides of the bottom of the chair are provided with a front kick amplitude marking component for marking the degree of the tester's knee jerk reaction. The utility model uses the front kicking calf to pull a whiteboard pen to draw a line on a magnetic whiteboard, and uses a scale line to read the length of the line. The stronger the knee jerk reaction, the longer the line length, and vice versa, the weaker the knee jerk reaction, the shorter the line length. A doctor can intuitively read the length of the line through the scale line, and can know the strength of the tester's knee jerk reaction without multiple tests. The utility model can help doctors diagnose whether people's lower motor nerves are damaged, and the utility model will not apply a force to the tested calf, so as not to hinder the tester's calf from performing a front kicking action, which helps to ensure the accuracy of the test results.

A brain-computer interface ('BCI') system provides more meaningful autonomy and independence for paralyzed individuals. Comprising a BCI system used by an individual that requires less assistance by a caregiver or even does not require a caregiver, providing an objective and functional measurement of the effectiveness of a motor nerve prosthesis in restoring motor output.

The invention provides a quaternary ammonium salt derivative as well as a preparation method and application thereof, and relates to the field of medicinal chemistry. The structure of the quaternary ammonium salt derivative is as shown in formula I in the specification. The compound disclosed by the invention is excellent in sensory and motor nerve separation and retardation effect, good in safety during use and relatively long in action time. Therefore, the compound provided by the invention has a wide application prospect in preparation of sensorimotor-separated local anesthetic drugs.

The invention provides an application of MCU (Microprogrammed Control Unit) in treating addictive diseases. By means of a conditional knockout dopamine system mouse model, it is observed that motonous nerve excitability caused by heroin, morphine and methamphetamine is remarkably reduced due to deficiency of MCU. In addition, behavioral experiments further prove that the MCU knockout significantly reduces the addiction desire of mice to heroin and methamphetamine. By applying MCU inhibitors, namely mitoxantrone (MTX) and Ru265, the inhibitors are found to be capable of remarkably inhibiting motor nerve excitability caused by heroin and reducing addiction and relapse behaviors of mice on heroin. Mechanism research reveals that MCU knockout inhibits dopamine release caused by opioids and methamphetamine in a nucleus septum (NAc) area, and it is indicated that MCU may serve as an effective target for treating addiction of multiple drugs. The invention provides a brand-new treatment strategy for inhibiting MCU as a clinical treatment for opioid (morphine) or drug (heroin) and methamphetamine addiction for the first time.

The invention belongs to the technical field of microorganisms, and particularly relates to plant lactobacillus with the function of improving the muscle function and the athletic ability and a product and application of the plant lactobacillus. According to the invention, the phytobacterium plantarum Vigo6 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35628 can promote the development of motor nerves, improve the form and density of muscle fibers, increase the muscle content and enhance the arrangement tightness of the muscle fibers; the effects of improving sarcopenia, promoting muscle growth, improving muscle strength, enhancing body coordination and balance ability, improving endurance and physical ability and improving muscle attenuation and aging equivalence are achieved. The lactobacillus plantarum Vigo6 disclosed by the invention has high intestinal tolerance, high storage stability, high safety and no pathogenicity, provides a new effective strain resource for developing related products for improving muscle health and athletic ability, and has a wide application prospect.

There is provided a transvenous approach for accessing and targeting neural treatment sites to relieve a variety of clinical indications, including peripheral neuropathy. A neurosome approach is described that includes one or more target nerves to receive selective cryoneurolysis via a target vein. A range of different freeze and thaw cycles are performed via the target vein to induce a desired thermal treatment temperature range for selective sensory loss without adverse impact or minimal impact to associated motor nerves. The target nerves and veins are selected to combine the treatment of the identified neurosome for pain relief in addition to the regenerative properties of cryoneurolysis.

The present invention relates to a composition for preventing or treating neurodegenerative or motor neuron diseases, comprising halofuginone as an active ingredient. Specifically, it has been confirmed in cell and animal models of amyotrophic lateral sclerosis (ALS) that halofuginone exhibits dual effects of suppressing fibrosis, improving skeletal muscle production, and improving joint structure, as well as suppressing inflammatory responses and neuronal death in the central nervous system, thereby delaying the progression of ALS symptoms and improving performance and survival time. Therefore, the halofuginone can be usefully used as an active ingredient in a composition for preventing or treating neurodegenerative or motor neuron diseases, including ALS.

A quaternary ammonium salt compound of formula I is fast-acting and has a long-term local anaesthetic effect after a single administration, the sensory nerve block time being longer than the motor nerve block time, has both a long-acting local anaesthetic effect and a selective local anaesthetic effect, and also significantly reduces the side effects of quaternary ammonium salt compounds with the structural features of surfactants and is highly safe; thus, the compound of formula I and the pharmaceutically acceptable salt thereof can be used for the preparation of saft drugs having a long-term local anaesthetic effect and a selective local anaesthetic effect

The invention discloses application of S-adenosylhomocysteine in preparation of a medicine for treating neuromuscular diseases, and belongs to the technical field of medicines. The invention discloses a novel pharmaceutical application of S-adenosine homocysteine in preparation of drugs for treating neuromuscular diseases for the first time. Mechanism research finds that S-adenosylhomocysteine can enhance the ability of a Trmt61a / 6 compound to bind unmethylated tRNA and inhibit abnormal interaction between CMT2 pathogenic mutant protein and stress particle core protein, so that the ability of motor neurons to resist external stress is enhanced, and the S-adenosylhomocysteine has the effects of improving peripheral nerve and muscle lesions of neuromuscular diseases, improving the immunity of the motor neurons and improving the immunity of the motor neurons. And the potential of motor nerve dysfunction. The invention provides a direction for new clinical application of the S-adenosyl homocysteine. The invention provides possibility for preparing novel medicines for treating neuromuscular diseases.

The invention belongs to the technical field of biology, and discloses a kit for inducing stem cells to be differentiated into motor nerve progenitor cells, motor nerve precursor cells and / or motor neurons and application of the kit. The kit adopts a culture medium with definite chemical components, small chemical molecules and cytokines, does not involve animal-derived components and other substances which easily bring unstable factors such as batch difference, can be clinically used, makes up for the deficiency of reagents adopted by the existing differentiation method, and has a good application prospect. The prepared motor nerve progenitor cells, motor nerve precursor cells and motor neurons have high purity, are suitable for cell transplantation and related disease treatment, and can be applied to clinical product development.

The utility model discloses a portable intra-operative motor nerve micro-current stimulator which comprises a detector, a loop electrode, a stimulation assembly, a loop wire and a stimulation wire. The front end of the detector is connected with the loop electrode and the stimulation assembly through a loop wire and a stimulation wire. The hand part is stimulated through the stimulation assembly, and meanwhile the loop electrode is fixed to the skin to form a loop; meanwhile, the fixing assembly is detachably installed on the outer side of the loop electrode, the loop electrode penetrating into the skin can be fixed through the arranged fixing assembly, the loop electrode is not prone to being pulled down, and compared with a traditional detector, effective fixing can be achieved, and the detection efficiency is improved. And the problem of prolapse caused by the use of the stimulating electrode at the front end is solved.

Aspects of the present disclosure relate to compositions and methods for modulating the translation of one or more RNA transcripts (e.g., mRNA transcripts) in a cell or subject. The present disclosure is based, in part, on isolated nucleic acids that bind to an mRNA transcript of a gene involved in L-serine biosynthesis, such as serine palmitoyltransferase long chain base subunit 1 (SPTLC1). In some embodiments, the compositions of the present disclosure are useful for the treatment of diseases or conditions associated with dysregulation of L-serine biosynthesis, such as retinal diseases (e.g., MacTel2 and age-related macular degeneration (AMD), such as AMD with geographic atrophy), HSAN1 (e.g., HSAN1 (a)), diabetic retinopathy, peripheral neuropathy (e.g., neuropathy), and the treatment of diseases or conditions associated with dysregulation of L-serine biosynthesis, such as retinal diseases (e.g., MacTel2 and age-related macular degeneration (AMD), such as AMD with geographic atrophy). ), neurodegenerative disorders (e.g., Parkinson's disease, Friedel's ataxia, motor neuron disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), etc.), spasmodic paraplegia or psychiatric disorders (e.g., neurodegenerative disorders, neurodegenerative disorders, etc. ), resistant depression, refractory depression, schizophrenia, and / or refractory schizophrenia.

There is provided a transvenous approach for accessing and targeting neural treatment sites to relieve a variety of clinical indications, including peripheral neuropathy. A neurosome approach is described that includes one or more target nerves to receive selective cryoneurolysis via a target vein. A range of different freeze and thaw cycles are performed via the target vein to induce a desired thermal treatment temperature range for selective sensory loss without adverse impact or minimal impact to associated motor nerves. The target nerves and veins are selected to combine the treatment of the identified neurosome for pain relief in addition to the regenerative properties of cryoneurolysis.

The invention discloses application of nucleoside compounds in preparation of drugs for treating neuromuscular diseases, and belongs to the technical field of medicines. The invention discloses a novel pharmaceutical application of the nucleoside compound in preparation of drugs for treating neuromuscular diseases for the first time. Research finds that the nucleoside compound can enhance the ability of a Trmt61a / 6 compound to bind unmethylated tRNA and inhibit abnormal interaction between pathogenic mutant protein and stress particle core protein, so that peripheral nerve and muscle lesions of neuromuscular diseases and motor nerve dysfunction are improved. The invention provides a direction for new clinical application of nucleoside drugs. The invention provides possibility for preparing novel medicines for treating neuromuscular diseases.

To provide a therapeutic agent targeting a complement cascade.SOLUTION: The present invention relates to a method of treating a paraproteinemic neuropathy in a subject by administering to the subject an antagonist of a complement system. The antagonist inhibits the complement system upstream of complement factor C5. More specifically, the antagonist may be an antibody or an antigen-binding fragment thereof that blocks or inhibits the complement system by inhibiting a C2b domain of complement factor C2. The paraproteinemic neuropathies that may be treated include, in particular, multifocal motor neuropathy (MMN), chronic inflammatory demyelinating polyneuropathy (CIDP), and Guillain-Barre syndrome (GBS).SELECTED DRAWING: Figure 1

A method is provided that includes identifying a subject as suffering from a headache or a migraine within a head of the subject, and, in response thereto, applying electrical energy to skin on an arm, a leg, a hand, or a foot of the subject's body by driving electrical pulses into the portion of the subject's body. The electrical pulses are configured such that more than 50 percent of the applied electrical energy stimulates A-beta sensory nerve fibers, and less than 20 percent of the applied electrical energy stimulates any one of A-delta sensory nerve fibers, C sensory nerve fibers, and motor nerve fibers. Other embodiments are also described.