24 results about "Motor nerve" patented technology

The invention belongs to the field of brain-computer interfaces, and particularly relates to a decision-making brain-computer method and device based on virtual reality induction, which combines two psychological decision-making tasks of auditory stimulation and visual stimulation and utilizes virtual reality equipment to create a decision-making brain-computer interface normal form of panoramic interaction, so that a subject can fit a scene facing a decision in reality to the greatest extent, and the accuracy of decision making is improved. The sensory motor cortex is effectively activated, and cooperative activation of the cognitive-motor neural network is induced; a decision interaction feedback link is added to enhance a decision stimulation effect and a cranial nerve feedback mechanism by analyzing related characteristics P300, power spectral density and brain network function connection quantity of the acquired electroencephalogram signals during normal form execution decision reaction. Compared with the prior art, the method has the advantages that immersive audio-visual stimulation and task interaction feedback are brought into a decision-making brain-computer interface for the first time, and a new scheme with neural rehabilitation and human-computer interaction functions is provided for neural feedback training of cognitive functions.

The invention discloses bifidobacterium animalis subsp. Lactis and application thereof in a product for enhancing athletic ability, and relates to the technical field of microorganisms. The invention provides an animal bifidobacterium subsp. Lactis MUS < + >, and the preservation number of the animal bifidobacterium subsp. Lactis MUS < + > is CGMCC (China General Microbiological Culture Collection Center) No.35626. The invention also provides a preparation method of the animal bifidobacterium subsp. Lactis MUS < + >. The animal bifidobacterium subsp. Lactis MUS + provided by the invention can increase the length of surrounding motor nerves and promote the development of the motor nerves; the total exercise distance is increased, and the exercise ability and endurance are promoted; body length or height development is promoted; muscle fibers are thickened, the muscle fiber density is increased, muscle fiber gaps are reduced, and muscle development is promoted; and the method has a very good application prospect in preparation of products for improving athletic ability or increasing muscle.

The invention relates to the technical field of medical monitoring, and particularly discloses an AI anesthesia depth monitoring system combined with nerve stimulation, which is characterized in that standardized electrical stimulation is applied to a motor nerve pathway of a patient in a general anesthesia state, and spinal nerve electrical signals and limb movement signals induced by the standardized electrical stimulation are synchronously acquired and analyzed; performing time-frequency transformation on the neural signal to extract a dominant oscillation mode of the neural signal, and generating a neural rhythm disorder degree characteristic value by quantizing frequency jitter and amplitude attenuation; analyzing the time sequence collaboration of the motion signal and the stimulation and the motion form, and generating a motion response deviation characteristic value; fusing the two features into a two-dimensional feature vector, inputting the two-dimensional feature vector into a pre-trained anesthesia depth classification model, and directly outputting an objective anesthesia depth level; and finally, starting grading early warning according to the grade change trend and generating a monitoring report.

The present invention relates to the field of pharmaceutical chemistry, and provides a quaternary ammonium salt derivative, and a preparation method therefor and a use thereof. The structure of the quaternary ammonium salt derivative is as shown in formula I. The compound of the present invention has an excellent differential blocking effect on sensory and motor nerves, high safety during use, and a long duration of action. Thus, the compound of the present invention has wide application prospects in the preparation of local anesthetic drugs for sensory-motor dissociation.

The embodiment of the application discloses a motor nerve muscle blood vessel coupling function detection system, which comprises a muscle oxygen measurement module, which is covered on a to-be-detected part and is used for acquiring a muscle oxygen signal of the to-be-detected part under a motor stimulation, wherein the muscle of the to-be-detected part is associated with a target motor nerve; a processor, which is used for acquiring state time information; acquiring the muscle oxygen signal of the to-be-detected part under the motor stimulation through the muscle oxygen measurement module; determining a time response characteristic parameter of the muscle oxygen signal based on the state time information; and determining a motor nerve muscle blood vessel coupling analysis result of the to-be-detected part based on the time response characteristic parameter. The motor nerve muscle blood vessel coupling function cannot be used for detecting the motor nerve muscle blood vessel coupling function in the prior art.

The invention relates to an amyotrophic lateral sclerosis zebrafish model based on beta-methylamino-L-alanine induction as well as a construction method and application of the amyotrophic lateral sclerosis zebrafish model. According to the method for constructing the amyotrophic lateral sclerosis model by inducing the zebrafish through the BMAA, the non-specific fatality rate in the early stage of modeling is effectively reduced by limiting the initial development node and culture conditions of toxin exposure, and the living animal model with typical motor nerve injury phenotype and good repeatability is obtained. The method is short in construction period and relatively low in experiment cost, can objectively reflect sporadic ALS pathological characteristics induced by environmental factors, and is suitable for being used as an in-vivo biological carrier for high-throughput preliminary screening of anti-ALS drugs and related neurotoxicological researches.

The invention provides a quaternary ammonium salt derivative as well as a preparation method and application thereof, and relates to the field of medicinal chemistry. The structure of the quaternary ammonium salt derivative is as shown in formula I in the specification. The compound disclosed by the invention is excellent in sensory and motor nerve separation and retardation effect, good in safety during use and relatively long in action time. Therefore, the compound provided by the invention has a wide application prospect in preparation of sensorimotor-separated local anesthetic drugs.

The invention belongs to the technical field of microorganisms, and particularly relates to plant lactobacillus with the function of improving the muscle function and the athletic ability and a product and application of the plant lactobacillus. According to the invention, the phytobacterium plantarum Vigo6 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35628 can promote the development of motor nerves, improve the form and density of muscle fibers, increase the muscle content and enhance the arrangement tightness of the muscle fibers; the effects of improving sarcopenia, promoting muscle growth, improving muscle strength, enhancing body coordination and balance ability, improving endurance and physical ability and improving muscle attenuation and aging equivalence are achieved. The lactobacillus plantarum Vigo6 disclosed by the invention has high intestinal tolerance, high storage stability, high safety and no pathogenicity, provides a new effective strain resource for developing related products for improving muscle health and athletic ability, and has a wide application prospect.

There is provided a transvenous approach for accessing and targeting neural treatment sites to relieve a variety of clinical indications, including peripheral neuropathy. A neurosome approach is described that includes one or more target nerves to receive selective cryoneurolysis via a target vein. A range of different freeze and thaw cycles are performed via the target vein to induce a desired thermal treatment temperature range for selective sensory loss without adverse impact or minimal impact to associated motor nerves. The target nerves and veins are selected to combine the treatment of the identified neurosome for pain relief in addition to the regenerative properties of cryoneurolysis.

The invention discloses application of S-adenosylhomocysteine in preparation of a medicine for treating neuromuscular diseases, and belongs to the technical field of medicines. The invention discloses a novel pharmaceutical application of S-adenosine homocysteine in preparation of drugs for treating neuromuscular diseases for the first time. Mechanism research finds that S-adenosylhomocysteine can enhance the ability of a Trmt61a / 6 compound to bind unmethylated tRNA and inhibit abnormal interaction between CMT2 pathogenic mutant protein and stress particle core protein, so that the ability of motor neurons to resist external stress is enhanced, and the S-adenosylhomocysteine has the effects of improving peripheral nerve and muscle lesions of neuromuscular diseases, improving the immunity of the motor neurons and improving the immunity of the motor neurons. And the potential of motor nerve dysfunction. The invention provides a direction for new clinical application of the S-adenosyl homocysteine. The invention provides possibility for preparing novel medicines for treating neuromuscular diseases.

Aspects of the present disclosure relate to compositions and methods for modulating the translation of one or more RNA transcripts (e.g., mRNA transcripts) in a cell or subject. The present disclosure is based, in part, on isolated nucleic acids that bind to an mRNA transcript of a gene involved in L-serine biosynthesis, such as serine palmitoyltransferase long chain base subunit 1 (SPTLC1). In some embodiments, the compositions of the present disclosure are useful for the treatment of diseases or conditions associated with dysregulation of L-serine biosynthesis, such as retinal diseases (e.g., MacTel2 and age-related macular degeneration (AMD), such as AMD with geographic atrophy), HSAN1 (e.g., HSAN1 (a)), diabetic retinopathy, peripheral neuropathy (e.g., neuropathy), and the treatment of diseases or conditions associated with dysregulation of L-serine biosynthesis, such as retinal diseases (e.g., MacTel2 and age-related macular degeneration (AMD), such as AMD with geographic atrophy). ), neurodegenerative disorders (e.g., Parkinson's disease, Friedel's ataxia, motor neuron disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), etc.), spasmodic paraplegia or psychiatric disorders (e.g., neurodegenerative disorders, neurodegenerative disorders, etc. ), resistant depression, refractory depression, schizophrenia, and / or refractory schizophrenia.

There is provided a transvenous approach for accessing and targeting neural treatment sites to relieve a variety of clinical indications, including peripheral neuropathy. A neurosome approach is described that includes one or more target nerves to receive selective cryoneurolysis via a target vein. A range of different freeze and thaw cycles are performed via the target vein to induce a desired thermal treatment temperature range for selective sensory loss without adverse impact or minimal impact to associated motor nerves. The target nerves and veins are selected to combine the treatment of the identified neurosome for pain relief in addition to the regenerative properties of cryoneurolysis.

The invention discloses application of nucleoside compounds in preparation of drugs for treating neuromuscular diseases, and belongs to the technical field of medicines. The invention discloses a novel pharmaceutical application of the nucleoside compound in preparation of drugs for treating neuromuscular diseases for the first time. Research finds that the nucleoside compound can enhance the ability of a Trmt61a / 6 compound to bind unmethylated tRNA and inhibit abnormal interaction between pathogenic mutant protein and stress particle core protein, so that peripheral nerve and muscle lesions of neuromuscular diseases and motor nerve dysfunction are improved. The invention provides a direction for new clinical application of nucleoside drugs. The invention provides possibility for preparing novel medicines for treating neuromuscular diseases.

This invention discloses a method and device for coordinated temporal modulation of central and peripheral ultrasound for children with motor neuron developmental disorders, comprising: acquiring multidimensional medical information and target physiological parameter information of the target child; prioritizing central and peripheral targets and determining the synergistic relationship between central and peripheral targets based on neural circuit conduction mechanisms; generating initialization timing parameters based on priority ranking and synergistic relationship, combined with a preset timing parameter database; controlling the ultrasound transducer to perform coordinated ultrasound stimulation on central and peripheral targets according to the initialization timing parameters, and monitoring the physiological response signal of the target child in real time; dynamically adjusting at least one of the initialization timing parameters, and continuing to perform coordinated ultrasound stimulation according to the adjusted timing parameters, thereby achieving synergistic enhancement by adjusting the timing to match the physiological neural conduction delay of the child, rather than basic synchronous energy superposition stimulation.

The invention relates to a massage assembly and a massage device thereof, and belongs to the technical field of massager production. Comprising hip massage electrode plates and an intelligent control box, and further comprises a pair of close-fitting shorts, a plurality of sets of hip massage electrode plates are arranged on the inner surface of the close-fitting shorts corresponding to the hip, and the intelligent control box is arranged on the outer surface of the close-fitting shorts corresponding to the abdomen. The hip massage electrode plates are electrically connected with a micro-current low-frequency pulse generator in the intelligent control box through wires. Compared with the prior art, the invention has the following beneficial effects: before wearing, the essence can be uniformly smeared on the electrode slice to infiltrate the electrode slice, or the essence is uniformly smeared on the buttocks, so that the conductive effect is better; based on the principle of bioelectricity, the technology of stimulating muscle movement through current is utilized, the device directly acts on the buttocks, enough motor nerves are stimulated through electromagnetic pulses, buttock muscle groups strongly move, the muscle groups are enlarged and thickened through movement, and therefore the effects of shaping and buttock enlarging are achieved in a short time.

This invention discloses a time-interference-based system for optimizing stimulation parameters of the subthalamic nucleus in Parkinson's disease, belonging to the field of stimulation parameter optimization technology. The system includes: a multimodal data acquisition and preprocessing module for acquiring motor neural data and performing data preprocessing; a gait electromyographic stability assessment module for analyzing motor stability characteristics to construct stability indices and determine stability improvement before and after stimulation; a stimulation dose-response modeling module for identifying the half-effect equivalent stimulation intensity and target stability level, inferring the potential improvement trend of the current stimulation, generating candidate stimulation parameter combinations and improvement predictions; and a comprehensive benefit parameter optimization module for fitting the improvement response time constant, obtaining an evaluation window, assessing the comprehensive benefit, and selecting recommended stimulation parameters. This invention solves the technical problem of existing technologies where large fluctuations and high noise in single-modal data make it difficult to stably reflect the patient's true neuromotor state, leading to unreliable stimulation parameter optimization.

New uses of populations of motor neural progenitor cells are provided, including reducing reactive astrocytes, reducing glial scars, inhibiting reactive astrocyte-mediated axonal regeneration impairment, neuronal and / or oligodendrocyte death, priming for altering protein factor expression profiles in cerebrospinal fluid, promoting axonal regeneration and / or recovery, reducing demyelination, and promoting remyelination and / or increasing myelin thickness, among others.

The application discloses a wearable electronic device for inhibiting static tremor based on antagonistic principle, which comprises an eagle-eye type three-electrode electromyographic signal detection device, an electromyographic signal amplification and processing unit, a functional electric stimulation signal generation unit, a pair of muscle functional electric stimulation electrodes and a wearable bandage, the eagle-eye type three-electrode electromyographic signal detection device and the pair of muscle functional electric stimulation electrodes are fixed on the opposite sides of the bandage, and the electromyographic signal amplification and processing unit and the functional electric stimulation signal generation unit are fixed on the same side of the bandage; the eagle-eye type three-electrode electromyographic signal detection device is used for detecting the motor action potential signal of the motor nerve of the agonist muscle causing the muscle tremor, the motor action potential signal is amplified, processed and mode-identified, and then is sent to the functional electric stimulation signal generation unit to generate the functional electric stimulation signal which is applied to the pair of muscle functional electric stimulation electrodes positioned on the surface of the antagonist muscle to stimulate the antagonist muscle to make the limb movement in the direction opposite to that of the agonist muscle, so that the effect of the agonist muscle is offset and the limb tremor is eliminated.

1. Name of the design product: Functional electrical stimulator for foot drop lower limb. 2. Use of the design product: To provide ankle dorsiflexion for foot drop patients caused by upper motor neuron injury or disease. 3. Design features of the design product: The shape of the product. 4. Picture or photo that best indicates the design features: perspective view.

This invention provides a foot support structure and sandals and insoles equipped with such a structure, designed to improve flat feet and floating toes by strengthening the muscles and motor nerves necessary for walking, as well as to prevent and improve bunions, hammertoes, ingrown toenails, etc. [Solution] In a foot sole placement structure 33 comprising a main body placement section 35 on which the part of the sole of the foot other than the toes is placed and a toe placement section 37 on which the toes are placed, the toe placement section 37 is formed to be lower in height than the main body placement section 35, and further, the toe placement section 37 has a first toe placement section 37A on which the inner first toe is placed, a fifth toe placement section 37E on which the outer fifth toe is placed, and intermediate toe placement sections 37B (C, D) on which the intermediate second, third, and fourth toes are placed, and the height of the first toe placement section 37A is set to be lower in height than the height of the intermediate toe placement sections 37B (C, D).

The invention belongs to the technical field of nerve regulation and control, and particularly relates to a percutaneous electrical nerve regulation and control system and method for pudendum nerve regulation and pelvic symptom treatment, and the system comprises a flexible skin patch module and a stimulation host; the stimulation host generates biphase symmetric pulse waves and transmits the biphase symmetric pulse waves to the flexible skin patch module, and the output current intensity is in a range higher than an individual sensory threshold value of a user but lower than an individual motion threshold value of the user, so that A beta sensory nerve fibers of perineum subcutaneous tissues are activated. Through the design of each module of the system, non-invasive electrical stimulation with specific parameters is realized, A beta sensory nerve fibers in a perineum region are selectively activated, different from muscle contraction caused by direct stimulation of motor nerves in the prior art, functional remodeling of a central nervous system can be initiated, and the perineum can be effectively stimulated. Therefore, long-acting and physiologic regulation of pelvic organ functions is realized.

The invention provides a magnetic-thermal double-control dynamic energy supply nano-motor nerve graft and a preparation method thereof, the nerve graft is composed of a degradable polymer fiber catheter, temperature-sensitive hydrogel filled in the nerve graft and a hydrogel-loaded nano-motor, and succinic acid and other energy molecules are loaded on the surface of the nano-motor. The nano-motor is prepared from a high magnetic response material, directional guidance is realized under the action of an external magnetic field, and heat generated under an alternating magnetic field can trigger the temperature-sensitive hydrogel to generate gel-sol conversion; energy molecules can be continuously released to improve local ATP level, maintain cell homeostasis and support axon regeneration and synaptic remodeling. The advantages of magnetic drive directional navigation and temperature-sensitive controlled release are fused, the defects that a traditional scheme is insufficient in orientation, lack of energy and the like are overcome, the graft is good in biocompatibility and biodegradable, the immune microenvironment of the injured nerve can be regulated and controlled, oxidative stress is avoided, and regeneration and functional recovery of the long-segment injured peripheral nerve are efficiently promoted.

The invention discloses a comprehensive testing device for sciatic nerve trunks, motor nerves and skeletal muscles. The comprehensive testing device comprises a specimen bearing assembly composed of PU plates, an electrophysiological signal collecting and stimulating assembly composed of acupuncture needles and miniature alligator clips, and a muscular tension testing assembly composed of a support and a tension transducer. The PU plate can fix an in-vitro spine-spinal nerve-sciatic nerve trunk-tibial nerve-gastrocnemius muscle integrated active specimen of a frog, and the acupuncture needle can puncture an adventitia and is arranged between nerve fascia membranes or puncture an adventitia of skeletal muscle and is arranged between muscular fascia membranes and is connected with a biological function data analyzer, so that electrical stimulation application and electric signal and electromyographic signal acquisition are realized, and the biological function data analyzer is connected with a biological function data analyzer. The tension transducer is connected with the specimen and synchronously collects muscular tension signals. Neural and muscle testing functions are integrated, the use amount of experimental animals is reduced, the signal-to-noise ratio of signals is increased through acupuncture needle puncture type collection, the PU plate is flexible in adaptation, the electrode distance is adjustable, and neural electrophysiological signals and muscular tension signals can be synchronously obtained.