29 results about "Sensory nerve" patented technology

Provided are a preparation method for and a use of a dorsal root ganglion organoid. In one aspect, a preparation method for a dorsal root ganglion organoid is provided, which comprises: (1) inducing stem cells in a neural stem cell induction medium, to obtain neural stem cells; (2) inducing the neural stem cells in a neural crest cell induction medium, to obtain neural crest cells; (3) inducing the neural crest cells in a sensory neural progenitor cell induction medium, to obtain sensory neural progenitor cells; (4) inducing the sensory neural progenitor cells in an organoid induction medium, to obtain a dorsal root ganglion organoid. In addition, a use of the dorsal root ganglion organoid obtained by said method is also provided, for example, for drug screening or disease research.

To provide a compound which is a local anesthetic and is useful for inducing selective sensory nerve block.SOLUTION: The compound is represented by formula (II).SELECTED DRAWING: None

The sensor nervous system (SNS) comprises an ecosystem where sensors can be deployed such that any sensor from any vendor can be integrated into or removed from the SNS without the need for redesigning the sensor, sensor system, or SNS to accommodate the changes in sensor device count, type, or functionality. The SNS is agnostic to which platform it is deployed upon and can be used for retrofitting and enhancing existing platforms or integrated into new platform designs. Individual sensors are integrated into sensor pods and the sensor pods are, in turn, integrated into the SNS ecosystem.

Provided herein are compounds that are local anesthetics and useful for inducing selective sensory nerve blockade. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of inducing selective sensory nerve blockade by administering the compounds and / or compositions to a subject.

This disclosure provides compositions and methods for treating sensorineural hearing loss and auditory neuropathy, particularly disease forms associated with otomorphin (OTOE) mutations, using OTOE gene therapy. The disclosure provides various compositions comprising a first nucleic acid vector containing a polynucleotide encoding the N-terminal portion of an OTOE isoform 5 protein and a second nucleic acid vector containing a polynucleotide encoding the C-terminal portion of an OTOE isoform 5 protein. These vectors can be used to increase OTOE expression in subjects, such as human subjects with sensorineural hearing loss.

The invention discloses a digital integrated brain injury nerve regulation diagnosis and treatment platform, and relates to the technical field of brain injury diagnosis and treatment, and the technical scheme is characterized in that the platform comprises a multi-mode brain function monitoring module used for collecting brain function data of a brain injury consciousness disorder patient in real time; the multi-sensory nerve regulation and control stimulation module is used for cooperatively applying multi-sensory stimulation to the patient; and the main control and data processing module receives and processes the multi-modal signals transmitted by the multi-modal brain function monitoring module, generates a personalized nerve regulation scheme by extracting brain function characteristics, and controls the multi-sensory nerve regulation stimulation module to execute the personalized nerve regulation scheme at the same time. According to the method, multi-sensory stimulation is cooperatively applied to the patient, the problem of pain points of traditional distributed non-standard stimulation is solved, the core requirement of the patient for multi-channel sensory input awakening is met, meanwhile, a complete closed loop of monitoring-analysis-intervention-feedback is formed, and dynamic evaluation and accurate intervention on the brain function state of the patient with acute brain injury consciousness disorder are achieved.

The application discloses a kind of sensation nerve quantitative detection method and system based on electroencephalogram characteristics, it is related to electroencephalogram measurement technical field, including: establishing and corresponding detection file of user;Respectively current stimulation module and electroencephalogram detection module are worn in the wrist of user and head;By current stimulation module, current stimulation is gradually applied to user, and gamma wave in the electroencephalogram signal of user is collected in real time by electroencephalogram detection module;Analysis gamma wave in the electroencephalogram signal of user, whether the current intensity that current stimulation module applies to user exceeds the physical stimulation perception threshold of subject is judged;Analysis sensation disorder severity classification.The application has the advantages that: detection is carried out by electroencephalogram signal, does not depend on the subjective feedback of patient, avoids the interference of emotion, psychology and other factors, even if special patient cannot carry out self-perception report, sensation nerve quantitative detection can also be completed by objective physiological response of electroencephalogram.

The present invention relates to brain derived nerve factor (BDNF) for use in the prevention or treatment of sensorineural hearing loss in a subject, wherein said BDNF is administered intranasally to said subject.

Provided herein are compounds that are local anesthetics and useful for inducing selective sensory nerve blockade. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of inducing selective sensory nerve blockade by administering the compounds and / or compositions to a subject.

The invention discloses an implantable intelligent blood pressure adjusting method and system based on a micro-nano ultrasonic device, and relates to the technical field of biomedical engineering.The implantable intelligent blood pressure adjusting method comprises the steps that a lithium niobate piezoelectric micromechanical ultrasonic transducer implanted near the renal door and the renal artery is controlled, and ultrasonic beams with the set center frequency are emitted to the blood vessel wall; echo signals reflected by the front wall and the rear wall of the blood vessel are collected; performing time domain peak detection on the echo signals, calculating the transit time of ultrasonic waves in a blood vessel cavity, calculating the instantaneous diameter of the blood vessel by combining the sound velocity, generating a real-time blood pressure value based on inversion of a blood vessel wall elastic mechanical model, and generating a blood pressure state judgment result; transmitting set intensity focused ultrasound to act on renal door sensory nerves according to a judgment result, and activating sensory pathways to release calcitonin gene-related peptides to induce vascular smooth muscle relaxation so as to reduce blood pressure. The lead-free single crystal lithium niobate piezoelectric micromechanical ultrasonic transducer is introduced, so that the biocompatibility and safety of the implanted device are greatly improved.

The application discloses a nose-sucking type smoking-cessation device and a medicine carrier thereof, which comprises a nose-sucking part and a medicine carrier bin connected to the lower part of the nose-sucking part; wherein one end of the medicine carrier bin close to the nose-sucking part is provided with a releasing end, and the releasing end is connected with a medicine carrier bin clamping end; a medicine transmission channel is formed between the nose-sucking part and the medicine carrier bin. The replaceable medicine carrier is driven by the pressure difference generated by nasal inhalation to transmit the medicine from the medicine carrier bin to the nose-sucking part through the channel, and the trace medicine is used to act on the olfactory sensory nerve of the nasal cavity to achieve the purpose of smoking cessation. The application has the advantages of simple structure, no power supply, no electronic elements, no smoke, no open fire and suitability for various environments.

This application relates to the field of traditional Chinese medicine (TCM) technology, disclosing a TCM compound composition, its preparation method, and its application in treating discogenic low back pain. The TCM compound composition comprises the following components in parts by weight: Astragalus membranaceus 30g, Ligusticum chuanxiong 18g, Angelica sinensis 9g, Rehmannia glutinosa (processed) 18g, Paeonia lactiflora (fried) 18g, Codonopsis pilosula 9g, Bupleurum chinense 9g, Poria cocos 9g, Stephania tetrandra 9g, Aconitum carmichaelii (processed) 9g, and Angelica pubescens 9g. This TCM compound composition improves the metabolism and structural state of multifidus muscle, restores the mechanical stability of spinal segments, reduces the continuous input of abnormal mechanical stimulation from the source, thereby inhibiting the activation of the Piezo1-Netrin-1 axis, reducing vascular and sensory nerve ingrowth, and ultimately resulting in the protection of the cartilaginous endplate structure and improved pain sensitivity.

Disclosed in the present invention is a wearable device for treating or preventing headache, comprising a stimulator and a flexible fixing member connected to the stimulator, wherein the flexible fixing member can fix the stimulator on the wrist, head or upper arm. The wearable device further comprises: a first electrode for targeting wrist nerves in the wrist, the stimulator being configured to provide an electric stimulation to the wrist nerves in the wrist via the first electrode; and a second electrode for targeting frontal nerves in the head and the sensory nerve C-type fibers in the upper arm, the stimulator being configured to provide an electric stimulation to the frontal nerves in the head and the sensory nerve C-type fibers in the upper arm via the second electrode. Since the wearable device can be worn on the wrist, head or upper arm, patients can freely choose a wearing position on the basis of current usage occasions and personal preferences, so as to meet the needs of the patients for use in various occasions, and achieve the convenience of daily carrying, thereby greatly improving the convenience in use of headache treatment devices, and providing users with more options.

The invention discloses an environment sensing bionic robot wolf applied to the field of robot wolves, which comprises a control part and a sensing head mounted on the left side of the upper end of the control part, and can accurately sense extreme weather conditions through the cooperation of a traction arc block, an identification protection assembly and an identification protection system. An active protection mechanism for the sensing cover can be automatically activated under a severe weather condition, so that the negative influence of an extreme environment on sensing recognition is remarkably weakened, the environment sensing precision of the sensing nerve acquisition unit is effectively improved, the task execution reliability of the bionic robot wolf under a complex working condition is ensured, and meanwhile, the service life of the bionic robot wolf is prolonged. Data interconnection is achieved through wireless signals and a central control monitoring platform, an efficient information transmission channel is constructed, the integrity and timeliness of environment recognition data are guaranteed, the comprehensive capacity of the bionic robot wolf in the aspect of multi-source information processing is further enhanced, and finally the comprehensive improvement of the environment adaptability and the function efficiency of the bionic robot wolf is achieved.

The utility model discloses a wearable device for treating or preventing headache, which comprises a stimulator and a flexible fixing piece connected with the stimulator, and the flexible fixing piece can fix the stimulator on a wrist, a head or an upper arm; the first electrode is used for targeting wrist nerves on the wrist, and the stimulator is configured to provide electrical stimulation for the wrist nerves on the wrist through the first electrode; the second electrode is used for targeting frontal nerves of the head or sensory nerve C-type fibers on the upper arms, and the stimulator is configured to provide electrical stimulation for the frontal nerves of the head or the sensory nerve C-type fibers on the upper arms through the second electrode; the wearable device can be worn on the wrist, the head or the upper arm, so that a patient can freely select the wearing position according to the current use occasion and preference, the use requirements of the patient in various use scenarios can be met, the wearable device is convenient to carry daily, the use convenience of the headache treatment instrument is greatly improved, and more choices are provided for a user.

This invention provides the application of berberine II derivatives in the preparation of drugs for treating diabetic foot, belonging to the field of biomedical technology. This invention is the first to discover that berberine II derivatives can significantly improve symptoms such as decreased motor / sensory nerve conduction velocity and loss of pain sensation in diabetic foot model rats, and promote wound healing in the affected foot. Berberine II derivatives hold promise for further development and research as a novel drug for treating diabetic foot.

The invention relates to the technical field of food, and particularly discloses a composition for promoting auditory sense system development and application. The composition is prepared from the following components in parts by mass: 0.1 part of IGF-1 and 1 to 1500 parts of structural triglyceride. A specific amount of IGF-1 is compounded with structural triglyceride, so that the movement speed and average movement distance of the zebrafish after auditory stimulation can be increased, the content of 5-hydroxytryptamine and acetylcholin esterase in the zebrafish is increased, the expression of GABA receptor genes is promoted, and the yield of the zebrafish is increased. By adding important neurotransmitters in an auditory sense system, auditory sense neuron survival, differentiation and synaptic formation are supported, so that the excitability of an auditory sense nerve pathway is adjusted, and the development of the auditory sense system is promoted. The composition can be used for preparing food such as infant formula milk powder, child formula milk powder, liquid milk, infant complementary food, supplements or dietary supplements.

The invention relates to a preparation method and application of dorsal root ganglion organoid. On one hand, the invention provides the preparation method of the dorsal root ganglion organoid, which comprises the following steps: (1) inducing stem cells in a neural stem cell induction culture medium to obtain neural stem cells; (2) inducing the neural stem cells in a neural crest cell induction culture medium to obtain neural crest cells; (3) inducing the neural crest cells in a sensory nerve progenitor cell induction culture medium to obtain sensory nerve progenitor cells; and (4) inducing the sensory nerve progenitor cells in the organoid induction culture medium to obtain the dorsal root ganglion organoid. Moreover, the invention also provides application of the dorsal root ganglion organoid obtained by the method, for example, the dorsal root ganglion organoid is used for drug screening or disease research.

This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a piperazine or piperidine structure which function as either inhibitors of pan-T-type calcium channel activity (e.g., CaV3.1 voltage gated calcium channel activity) (e.g., CaV3.2 voltage gated calcium channel activity) (e.g., CaV3.3 voltage gated calcium channel activity) (e.g., depolarization-induced calcium influx) or specific inhibitors of CaV3.2 voltage gated calcium channel activity, and their use as therapeutics for the treatment and / or prevention of pan-T-type calcium channel related pain (e.g., CaV3.1 related pain) (e.g., CaV3.2 related pain) (e.g., CaV3.3 related pain) (e.g., HIV-associated peripheral sensory neuropathy, chemotherapy-induced peripheral neuropathy (CIPN), spinal nerve ligation (SNL) induced neuropathy) (e.g., tonic, neuropathic, and / or inflammatory pain) and related conditions.

The application discloses a device for rapid recovery of body perception after anesthesia, which is used for helping patients recover body perception faster after operation. The device is composed of a temperature rising wrapping blanket, a pneumatic touching assembly, a micro vibration motor array and a sound stimulation assembly. The temperature rising wrapping blanket wraps the patient's body, uses graphene heating wires to create a warm environment and promotes blood circulation. The pneumatic touching assembly pumps air to the silica gel airbag through a micro air pump, so that the silica gel airbag intermittently touches the patient's body, and a flexible pressure sensor monitors the touching pressure. The micro vibration motor array vibrates at different frequencies and intensities, gently awakens the sensory nerves. The sound stimulation assembly plays sound through a Bluetooth sound box, activates the auditory nerves. The components work together, and the device can adjust the stimulation intensity according to the patient's recovery condition, realize the stimulation of the mode and adapt the recovery process, help the patient shorten the stay time in the PACU, improve the turnover rate and improve the postoperative experience.

The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with a mutation in otoferlin (OTOF), by way of OTOF gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOF isoform 5 protein and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOF isoform 5 protein. These vectors can be used to increase the expression of OTOF in a subject, such as a human subject suffering from sensorineural hearing loss.

The application discloses a preparation method and application of a metformin grafted polycaprolactone nanoscaffold, and the polycaprolactone nanofiber membrane is coated with a layer of polydopamine in a weak alkaline Tri-HCl buffer solution, is blended with metformin in the weak alkaline Tri-HCl buffer solution, and is incubated on a shaking table at 37 DEG C, so that a product is obtained; after washing and freeze-drying, the metformin grafted polycaprolactone nanoscaffold is obtained. The METG-PCLN developed in the application can continuously release MET into the fibrotic microenvironment in sensory neurons and EFs. In vitro cell experiments and animal model experiments prove that the METG-PCLN can significantly slow down the development of EFs by finely adjusting the release of sensory nerve CGRP. Therefore, the application provides a promising proof of concept for the potential clinical treatment of EFs, and shows considerable conversion value.

Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of a stereocilin protein, and the use of these compositions to treat non-syndromic sensorineural hearing loss in a subject.

A referred sensation or neural haptic wearable includes an electrode array for transdermal stimulation of a sensory nerve that itself innervates a body part distal to a worn location of the referred sensation wearable. The transdermal stimulation is configured to induce an electrical current or voltage that evokes a sensory impression at an area innervated by the sensory nerve, not at the stimulated sensory nerve itself. In one implementation, the referred sensation wearable takes a finger ring form factor worn on a proximal phalanx of an index finger. In this configuration, the referred sensation wearable can stimulate a portion of a branch of the median nerve extending through the index finger. Upon stimulation of the median nerve, a user wearing the finger ring may perceive pressure applied to the user's fingertip.

Methods of treating tinnitus, acute sensorineural hearing loss, age-related hearing loss, or Meniere's disease, with a compound according to Formula (I), or a pharmaceutically acceptable salt thereof, are provided. Also provided are therapeutic compositions that may be used to improve one or more symptoms of tinnitus, acute sensorineural hearing loss, or Meniere's disease. Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and ring A have any of the meanings herein defined in the description.

The application discloses a composite scaffold material with the functions of promoting bone sensory nerve remodeling, blood vessel regeneration and bone rapid repair and a preparation method thereof. The preparation process comprises the following steps: ①preparing a core particle with a porous core-shell structure hydroxyapatite (HA) coating through biomimetic mineralization and in-situ pore forming technology; ②placing the particle into a buffer solution containing a first growth factor, electrostatically adsorbing the growth factor in the pores through ultra-high specific surface area, and further coating the pores with in-situ self-polymerization dopamine (DA) on the surface to obtain a composite particle; ③obtaining a decellularized matrix by treating animal soft tissues, sequentially adding a second growth factor and the composite particle, and preparing the composite scaffold material through low-speed centrifugal defoaming and low-temperature freeze-drying technology. The composite scaffold material has excellent degradation performance, biocompatibility, factor controlled release performance, nerve promoting performance, vascularization performance and bone induction performance, and can realize the treatment of refractory bone defects of different sizes.

Systems, devices, and methods for stimulating peripheral nerves in the fingers or hand to treat tremor are described. For example, a wearable ring device for delivering electrical stimulation to sensory nerves in a patient's finger can include an annular ring having a plurality of electrodes and a detachable unit having a power source and a pulse generator.

The invention belongs to the technical field of nerve regulation and control, and particularly relates to a percutaneous electrical nerve regulation and control system and method for pudendum nerve regulation and pelvic symptom treatment, and the system comprises a flexible skin patch module and a stimulation host; the stimulation host generates biphase symmetric pulse waves and transmits the biphase symmetric pulse waves to the flexible skin patch module, and the output current intensity is in a range higher than an individual sensory threshold value of a user but lower than an individual motion threshold value of the user, so that A beta sensory nerve fibers of perineum subcutaneous tissues are activated. Through the design of each module of the system, non-invasive electrical stimulation with specific parameters is realized, A beta sensory nerve fibers in a perineum region are selectively activated, different from muscle contraction caused by direct stimulation of motor nerves in the prior art, functional remodeling of a central nervous system can be initiated, and the perineum can be effectively stimulated. Therefore, long-acting and physiologic regulation of pelvic organ functions is realized.

The invention provides a craniofacial skeleton organoid controlled by sensory organs and sensory nerves and a preparation method thereof, and relates to the technical field of biologication.The preparation method comprises the steps that in a three-dimensional matrix, human pluripotent stem cells are induced through morphogenetic gradient driving to form nerve ectoderm with a nerve tube head-tail axis and a nerve tube back-abdominal axis; the neural ectoderm is respectively differentiated into a neural crest cell flow carrying head-tail axis position information, a visual cranium substrate-like structure carrying head-tail axis position information, an olfactory cranium substrate-like structure carrying head-tail axis position information and a trigeminal nerve cranium substrate-like structure carrying head-tail axis position information; and a craniofacial skeleton organ is formed under mediation of nerve cadherin. The technical problem that in the prior art, a method for forming a craniofacial skeleton organ through induction cannot form a sensory organ and a sensory nerve innervation function is solved.