92 results about "Sensory nerve" patented technology

The invention relates to the technical field of exercise rehabilitation, and discloses a percutaneous spinal nerve electrical stimulation system and method, and the system comprises a power module which is used for converting an external alternating current into a stabilized power supply; the MCU module controls the pulse signal generation module; the pulse signal generation module is used for generating an electrical stimulation waveform; the DAC module receives the digital signal; the modulation module is used for receiving analog signals; the amplification module is used for receiving modulation waveforms; the multi-channel gating module is used for distributing stimulation current to a plurality of channels; the current detection module monitors the magnitude of current output by each channel in real time; and the ADC module performs digital conversion on the current analog signal output by the electrical stimulator. According to the invention, multi-channel and real-time modulation electrical stimulation signals can be output through modulation of two paths of stimulation signals, spinal cord sensory nerves are activated through the non-invasive epidermal electrode, amputation hand feeling is induced, the defect that electromyographic signals are interfered by the tail end of a stump in the prior art is improved, and the accuracy of an electromyographic signal decoding algorithm is also improved.

The invention discloses a wearable fatigue monitoring and feedback method based on deep learning. The method comprises the steps that a heart rate variability signal, a gamma wave band electroencephalogram signal and body movement posture information of a user are collected in real time; denoising, normalizing and synchronously fusing the acquired multi-mode signals; extracting a fatigue state representation vector in real time by adopting a Mamba linear state space sequence model; estimating a user fatigue index in real time based on a lightweight full-connection neural network decoder and constructing an individual fatigue threshold dynamic model; calculating a phase synchronization index of the electroencephalogram signal in real time; and generating and outputting an individualized 40Hz gamma wave band sensory nerve stimulation feedback signal in real time based on the fatigue index and the phase synchronization index. According to the invention, high-robustness fatigue identification and low-delay feedback adjustment in a complex motion noise environment are realized.

The invention discloses a sensory nerve quantitative detection method and system based on electroencephalogram characteristics, and relates to the technical field of electroencephalogram measurement, and the method comprises the steps: building detection files in one-to-one correspondence with users; respectively wearing the current stimulation module and the electroencephalogram detection module on the wrist and the head of the user; current stimulation is applied to a user step by step through a current stimulation module, and gamma waves in electroencephalogram signals of the user are collected in real time through an electroencephalogram detection module; gamma waves in the electroencephalogram signals of the user are analyzed, and whether the intensity of current applied to the user by the current stimulation module exceeds a physical stimulation sensing threshold value of the subject or not is judged; and analyzing severity grades of sensory disorders. The method has the advantages that detection is carried out through brain wave signals without relying on subjective feedback of a patient, interference of factors such as emotion and psychology is avoided, and even a special patient who cannot carry out self-perception report can complete sensory nerve quantitative detection through objective physiological reaction of brain waves.

A wearable electronic device includes an electrode array for transdermal stimulation of a sensory nerve that itself innervates a body part distal to a worn location of the wearable electronic device. The transdermal stimulation is configured to induce an electrical current or voltage that evokes a sensory impression at an area innervated by the sensory nerve, not at the stimulated sensory nerve itself. In one implementation, the wearable electronic device takes a finger ring form factor worn on a proximal phalanx of an index finger. In this configuration, the wearable electronic device can stimulate a portion of a branch of the median nerve extending through the index finger. Upon stimulation of the median nerve, a user wearing the finger ring may perceive pressure applied to the user's fingertip.

The invention belongs to the technical field of medical treatment, and discloses an osteoarthritis rehabilitation auxiliary device and system, and the device comprises an intelligent vibration treatment module, a pressure sensor and biological feedback module, an intelligent control and APP remote management module, a pressure sensor, an accelerometer, and a myoelectricity sensor. The joint pain is relieved, vibration can stimulate sensory nerves, pain signal transmission is reduced, and the pain degree is reduced. Vibration promotes secretion of joint fluid, friction is reduced, and the range of motion is improved. Low-frequency vibration stimulates the activity of cartilage cells, and cartilage degeneration is slowed down. And a biological feedback system is intelligently regulated and controlled, so that the treatment accuracy is improved. Non-invasive treatment is achieved, and no side effect exists; gastrointestinal discomfort caused by drug treatment or high cost of long-term physical treatment is avoided. Remote monitoring is achieved, compliance is improved, a patient can be treated at home and does not need to see a doctor frequently, and medical cost is reduced.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for relieving side effects of oxaliplatin chemotherapy. The traditional Chinese medicine composition composed of radix paeoniae alba and liquorice is used for relieving various side reactions caused by oxaliplatin, wherein the side reactions comprise peripheral neurotoxicity, hematological toxicity and systemic reaction. The traditional Chinese medicine composition plays a role in relieving peripheral neurotoxicity caused by oxaliplatin through multiple ways, on one hand, neuroinflammatory response in dorsal root ganglions is inhibited, the dorsal root ganglions are responsible for receiving and conducting sensory nerve impulse, the injury is mainly represented as sensory disorders such as numbness of hands and feet, stabbing pain and delayed feeling, and on the other hand, the neuroinflammatory response in the dorsal root ganglions is inhibited; therefore, OIPN can be relieved by inhibiting the inflammatory reaction; on the other hand, the blood flow of microvessels is promoted, and the circulation disorder of the microvessels at the tail ends of the limbs is improved to relieve OIPN. Moreover, the traditional Chinese medicine composition does not influence the anti-tumor effect of oxaliplatin, is good in safety, and does not damage important organs such as heart, liver, spleen, lung and kidney.

The invention discloses a double-layer hydrogel stent capable of releasing medicine in time sequence as well as a preparation method and application of the double-layer hydrogel stent. The scaffold comprises an inner hydrogel and an outer hydrogel coating the inner hydrogel, the outer hydrogel is loaded with cell factors, and the cell factors have the following effects of collecting neutrophils and promoting polarization of the neutrophils into subtypes with stem cell collection; the inner layer hydrogel is loaded with neurotrophic factors. According to the hydrogel scaffold, ordered slow release of cell factors (such as IL-8) and neurotrophic factors (such as NGF) is achieved through the structural design of the inner hydrogel layer and the outer hydrogel layer, neutrophils and sensory nerves can be activated in sequence in a bone defect area, the neutrophils are collected in the defect area, stem cell homing is promoted, and osteogenesis is started; then, local sensory nerves are induced to grow in through the lagged and continuously released NGF, the sensory nerves are stimulated to play an immune regulation role, inflammation dissipation is promoted, and finally repair and regeneration of refractory bone defects are promoted.

A computer brain interface (CBI) device of an individual is self-calibrated. A neurostimulation test signal is generated based on a selected set of test signal parameters. The neurostimulation signal is applied to the afferent sensory nerve fibers to elicit a bioelectric response via a neurostimulation interface operably connected to or integrated with the CBI device. The neurostimulation interface senses the bioelectric responses of the stimulated afferent sensory nerve fibers. The CBI devices determines, based on the sensed bioelectric responses, whether an excitation behavior of the stimulated afferent sensory nerve fibers with respect to the neurostimulation interface has changed. When the excitation behavior has changed, a set of recalibrated neurostimulation signal parameters is determined based on the sensed bioelectric responses. The CBI device is operated using the recalibrated neurostimulation signal parameters to communicate information to the individual via neurostimulation of the afferent sensory nerve fibers.

Systems, devices, and methods for stimulating peripheral nerves in the fingers or hand to treat tremor are described. For example, a wearable ring device for delivering electrical stimulation to sensory nerves in a patient's finger can include an annular ring having a plurality of electrodes and a detachable unit having a power source and a pulse generator.

Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for monitoring or controlling bladder function in a patient.

The invention belongs to the technical field of anti-tumble devices, and discloses a tumble prevention device for sensing human joint position sensation and motion sensation based on brain-computer fusion, which comprises a brain-computer fusion sensing interface, an intelligent knee pad, a wearable system, a balance module, a support module and a control module, the signal is transmitted to sensory nerves through an electrode implanted into the brain, so that the sensory function is reconstructed; the mode of electromyographic signal detection and rigid structure supporting is adopted, the feature electromyographic signals before falling are collected, the mechanical supporting device is automatically triggered, supporting is guaranteed to be safe, detection and processing of the electromyographic signals of specific muscle groups before falling are achieved, and the safety of falling is improved. And the whole process of rigid support protection, alarm and sending positioning on the human body during falling is covered.

Provided is a portable pruritus treatment device which is capable of achieving a sufficient antipruritic effect in lieu of a drug therapy that causes systemic symptoms, and with which a patient can repeatedly perform radiation at home.　This pruritus treatment device is characterized in having a light beam source for emitting a light beam and a light beam radiation probe for radiating the light beam, and is characterized in that the light beam emitted by the light source is percutaneously radiated from the light beam radiation probe toward sensory nerves that dominate a pruritus occurrence site of the skin or the mucosal epithelium.

Provided is a composition for preparing a medicament for treating diabetic peripheral neuropathy. The pharmaceutical composition comprises cobra venom phospholipase A2, or a combination of cobra venom phospholipase A2 and at least one additional drug for treating diabetic peripheral neuropathy. The diabetic peripheral neuropathy is characterized by a slowdown in motor nerve conduction velocity and / or sensory nerve conduction velocity of a patient, and / or hypoesthesia or loss of sensation in both lower limbs. The pharmaceutical composition can be used to ameliorate the clinical symptoms described above in patients with diabetic peripheral neuropathy, and belongs to the field of biopharmaceuticals.

The present invention relates to salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharma-ceutically acceptable solvates thereof for use in the treatment and / or prevention of sensory neuron diseases.

Provided are a preparation method for and a use of a dorsal root ganglion organoid. In one aspect, a preparation method for a dorsal root ganglion organoid is provided, which comprises: (1) inducing stem cells in a neural stem cell induction medium, to obtain neural stem cells; (2) inducing the neural stem cells in a neural crest cell induction medium, to obtain neural crest cells; (3) inducing the neural crest cells in a sensory neural progenitor cell induction medium, to obtain sensory neural progenitor cells; (4) inducing the sensory neural progenitor cells in an organoid induction medium, to obtain a dorsal root ganglion organoid. In addition, a use of the dorsal root ganglion organoid obtained by said method is also provided, for example, for drug screening or disease research.

To provide a compound which is a local anesthetic and is useful for inducing selective sensory nerve block.SOLUTION: The compound is represented by formula (II).SELECTED DRAWING: None

The sensor nervous system (SNS) comprises an ecosystem where sensors can be deployed such that any sensor from any vendor can be integrated into or removed from the SNS without the need for redesigning the sensor, sensor system, or SNS to accommodate the changes in sensor device count, type, or functionality. The SNS is agnostic to which platform it is deployed upon and can be used for retrofitting and enhancing existing platforms or integrated into new platform designs. Individual sensors are integrated into sensor pods and the sensor pods are, in turn, integrated into the SNS ecosystem.

A wearable electronic device includes an electrode array for percutaneously stimulating sensory nerves that self-govern a body part distal to a wearing location of the wearable electronic device. The transcutaneous stimulation is configured to induce a current or voltage that induces a sensory impression at a region innervated by the sensory nerve and not at the stimulated sensory nerve itself. In one embodiment, the wearable electronic device employs a ring shape that is worn on the proximal phalanx of the index finger. In this configuration, the wearable electronic device may stimulate a portion of a branch extending through the median nerve of the index finger. When the median nerve is stimulated, a user wearing the ring can perceive pressure applied to the fingertip of the user.

Provided herein are compounds that are local anesthetics and useful for inducing selective sensory nerve blockade. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of inducing selective sensory nerve blockade by administering the compounds and / or compositions to a subject.

The invention discloses prevention and treatment of diseases by stimulating TRPV1 + sensory nerves. Specifically, the invention discloses application of a substance for stimulating TRPV1 + sensory nerves in preparation of products for prevention, treatment or adjuvant treatment of inflammatory diseases, autonomic nerve dysfunction diseases or adrenal insufficiency diseases, and application of the substance for stimulating TRPV1 + sensory nerves in preparation of products for inhibiting proinflammatory cytokines and products for promoting anti-inflammatory cytokines. The TRPV1 ion channel agonist disclosed by the invention can obviously and effectively inhibit the expression of numerous proinflammatory cytokines and obviously improve the expression of anti-inflammatory cytokines IL10, so that not only is the physiological status of an inflammatory mouse obviously improved, but also the survival rate of the inflammatory mouse is obviously improved; meanwhile, the spleen function can be adjusted, expression of spleen pro-inflammatory genes is remarkably inhibited, generation of catecholamine is increased, and secretion of cortisol hormones is promoted. The invention has wide clinical application value in prevention and treatment of related diseases.

This disclosure provides compositions and methods for treating sensorineural hearing loss and auditory neuropathy, particularly disease forms associated with otomorphin (OTOE) mutations, using OTOE gene therapy. The disclosure provides various compositions comprising a first nucleic acid vector containing a polynucleotide encoding the N-terminal portion of an OTOE isoform 5 protein and a second nucleic acid vector containing a polynucleotide encoding the C-terminal portion of an OTOE isoform 5 protein. These vectors can be used to increase OTOE expression in subjects, such as human subjects with sensorineural hearing loss.

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

Provided herein are compounds that are local anesthetics and useful for inducing selective sensory nerve blockade. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of inducing selective sensory nerve blockade by administering the compounds and / or compositions to a subject.

1. Name of the design product: Digital vibration perception threshold detector. 2. Use of the design product: Used to detect the vibration perception threshold of the subject and provide objective and accurate values for clinical judgment of sensory nerve function. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Stereogram.

The invention discloses an intelligent wearable device and method for relieving tremor. The intelligent wearable device comprises a wrist fixing part and a working part which are connected with each other. The wrist fixing component comprises a bracelet used for being fixed to the wrist of a user. The working component comprises a control unit, and a multi-mode sensing unit, a percutaneous sensory nerve stimulation unit and an environment sensing unit which are connected with the control unit. According to the technical scheme, the control signal is obtained through the mapping relation between the tremor mode and the stimulation parameters of the two-channel percutaneous stimulation model, the control signal is compensated according to the current scene information of the user and the current environment data, the adaptability is improved, and the tremor suppression effect is improved.

Provided herein are devices, systems and methods for restoring tactile sensation in a subject, using a subcutaneously implanted nanogenerator which is connected to at least one of the subject's sensory nerves and is configured to produce an electric signal upon external stimulus and provide the electric signal to the sensory nerve to thereby stimulate the nerve in accordance with the external stimulus.

System for effecting a reversible sensory block includes a hybrid neuromodulator and hybrid lead for delivering electrical and pharmacological stimulation. An implantable modulator provides electrical pulse generation and pharmacological fluid infusion. Method for effecting a reversible sensory block delivers low-frequency stimulation based on the conduction velocity of a target afferent. Afferents with different conduction velocities may be blocked by stimulation with different frequencies. Temporally synchronized pulse stimuli from multiple stimulating electrodes may interfere with each other to stimulate a specific afferent. Spatial summation of synchronized low-frequency pulse stimulation may be delivered at multi-sites. Temporal interference of two kilohertz sinusoidal stimuli with slight frequency difference deliver a low-frequency sinusoidal stimulus at a focal region of interference. Spatial summation translates to evoked action potentials that converge at T-junction of a targeted afferent. Pharmacological delivery of Na,K-ATPase inhibitors or antagonists to the DRG facilitates electrical stimulation for selective blockage of small-diameter nociceptor afferents.