197 results about "Peripheral neuropathy" patented technology

This disclosure relates to dosage forms comprising bupropion hydrochloride, another salt form of bupropion, or the free base form of bupropion; dextromethorphan hydrobromide, another salt form of dextromethorphan, or the free base form of dextromethorphan, and a polymer. In some embodiments, the dosage form has no significant dose dumping of bupropion in the presence of ethanol in vitro. In some embodiments, the dosage form does not have a food effect for bupropion or dextromethorphan when taken with a high-fat meal in human subjects. Some embodiments include a method of treating a nervous system condition (such as depression, e.g., major depressive disorder, including treatment-resistant depression, agitation associated with Alzheimer's disease (or agitation associated with dementia of the Alzheimer's type), agitation associated with dementia, anxiety (or generalized anxiety disorder), neuropathic pain, or peripheral diabetic neuropathic pain) comprising, administering a dosage form described herein to a human being in need thereof.

This disclosure relates to dosage forms comprising bupropion hydrochloride, another salt form of bupropion, or the free base form of bupropion; dextromethorphan hydrobromide, another salt form of dextromethorphan, or the free base form of dextromethorphan, and a polymer. In some embodiments, the dosage form has no significant dose dumping of bupropion in the presence of ethanol in vitro. In some embodiments, the dosage form does not have a food effect for bupropion or dextromethorphan when taken with a high-fat meal in human subjects. Some embodiments include a method of treating a nervous system condition (such as depression, e.g., major depressive disorder, including treatment-resistant depression, agitation associated with Alzheimer's disease (or agitation associated with dementia of the Alzheimer's type), agitation associated with dementia, anxiety (or generalized anxiety disorder), neuropathic pain, or peripheral diabetic neuropathic pain) comprising, administering a dosage form described herein to a human being in need thereof.

The present invention relates to a novel association or combination of active ingredients useful in the prevention and repair of neuronal damage, both centrally and peripherally. In greater detail, the present invention relates to an association or combination of i) an extract of Gastrodia elata and ii) at least one ingredient selected from the group comprising or, alternatively, consisting of citicoline, L-acetylcarnitine and, preferably, at least one vitamin of group D, and / or mixtures thereof, and / or at least one vitamin of group B, and / or mixtures thereof. Furthermore, the invention also relates to the pharmaceutical compositions and / or compositions for medical devices (Regulation (EU) 2017 / 745) and / or nutraceutical and / or food compositions comprising that association and to their use in therapy, in particular in the protection of the functionality of the nervous system and in the prevention and / or treatment of central and peripheral neuropathies.

For foot pain sufferers, especially those with peripheral neuropathy, this invention introduces a breakthrough device. Its key feature is a novel self-aligning applicator that simultaneously treats the entire foot and eliminates adjustments and sizing. A large enough and powerful enough treatment zone is possible by utilizing a segmented solenoid and by placing the foot directly into its coherent core flux. Dosages to the entire foot of 2,500 ΣΔBT can be achieved within an hour. Extremely low voltages are used and very little heat is produced, making the device suitable for in-home use.

The invention discloses a traditional Chinese medicine extract composition for treating diabetic complications and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine extract composition is mainly prepared from the following raw material extracts: raw radix astragali, rhizoma anemarrhenae, rhizoma atractylodis, cortex phellodendri, radix trichosanthis, fructus corni, radix puerariae and ginseng leaves. The traditional Chinese medicine composition is used for treating diabetes mellitus and various complications thereof, including diabetes mellitus complicated with coronary heart disease, diabetes mellitus complicated with hypertension, diabetes mellitus complicated with cerebrovascular lesion, diabetic nephropathy, diabetic fundus lesion, diabetic peripheral neuropathy and the like, and has the advantages of remarkable clinical curative effect, no obvious side effect, low price, good comprehensive therapeutic property and the like.

The invention discloses a novel injection containing edaravone and high-purity synthesized (+)-2-borneol, because the (+)-2-borneol is prepared by a chemical synthesis process, the curative effect of the (+)-2-borneol is better than that of natural borneol and (+)-2-borneol extracted from the natural borneol under the same dosage, the toxic and side effects can be reduced, and the product quality is more stable; and the established GC-MS analysis method can more accurately control the content of each coexisting substance and better guarantee the shelf life quality. The injection is more suitable for improving the treatment effect on central nervous system diseases, oxidative stress injuries such as diabetes, retinopathy, diabetic peripheral neuropathy and neurodegenerative diseases and thrombus-related diseases.

The invention discloses a curative effect evaluation method of balance needle therapy in diabetic peripheral neuropathy, and relates to the technical field of curative effect evaluation. Constructing a medical history tree diagram of the diabetic patient, obtaining medical history influence factors of the diabetic patient, constructing a physical sign change curve of the diabetic patient, obtaining change coefficients of different time nodes, generating a change coefficient set, and inputting the change coefficient set into a curative effect judgment model to obtain effective interval duration of the balance needle therapy, acquiring fluctuation values of different real-time parameters to judge whether abnormal real-time parameters exist or not, generating a curative effect evaluation set, acquiring single evaluation coefficients of different physical sign parameters, and generating a comprehensive evaluation coefficient and a curative effect evaluation result thereof; through the technical scheme of the invention, the pertinence, accuracy and comprehensiveness of the balance needle therapy for evaluating the curative effect of the diabetic peripheral neuropathy can be obviously improved.

The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1 / CXCR2 receptor inhibitors, useful in the treatment and / or prevention of chemotherapy-induced neuropathy, preferably in the treatment and / or prevention of chemotherapy-induced peripheral neuropathy (CIPN) or chemotherapy-induced optic neuropathy.

The invention discloses a diabetic foot management and control method for a diabetic patient and related equipment. The method comprises the following steps: periodically acquiring peripheral neuropathy examination data of a diabetic patient, wherein the period is dynamically determined based on historical diabetes data of the patient; generating a diabetic foot risk assessment problem table based on the peripheral neuropathy examination data and the diabetes historical data; and based on the peripheral neuropathy examination data and feedback data of the patient in response to the risk assessment problem table, predicting the diabetic foot disease risk level of the diabetic patient through a column diagram prediction model. The problem that a simple, feasible and easy-to-popularize diabetic foot prediction method is lacked at present can be solved.

Provided herein are methods for reducing the likelihood and / or severity of peripheral neuropathy, anemia, and / or neutropenia in an individual being treated with an antibody-drug conjugate (ADC). Also provided herein are methods for increasing dosing amount and / or frequency of an antibody-drug conjugate (ADC) in an individual. In some embodiments, the methods comprise administering to the individual an effective amount of an ADC that comprises an antibody conjugated to a drug moiety via a linker, wherein the antibody comprises a heavy chain comprising a human Fc region with reduced or eliminated effector function. Compositions, uses, and kits related thereto are also provided.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

Provided are a polylactic acid and a use of a copolymer thereof in the preparation of a drug for promoting nerve growth and repair. The molecular weight of the polylactic acid and the copolymer thereof is 400-300 k Da. The drug has the following effects: 1) promoting the growth of nerve cells and nervous tissue; 2) promoting repair of nerve cells and nervous tissue; and 3) treating or preventing a peripheral nerve injury, a spinal cord injury, peripheral neuropathy, and neuritis. The molecular weight is preferably 5000-100 k Da. It is found for the first time that the polylactic acid and the copolymer thereof have a protective effect on nerves, and can promote nerve growth and a nerve injury repair.

The present invention relates to an intelligent auxiliary inspection device for diabetic peripheral neuropathy, the inspection device comprising a pressure air pump (1), an infrared distance measuring sensor (2), an intelligent evaluation module (3), a control module (4), an auxiliary handle (5), an indicator light (6), a power supply (7), and a switch (8). Except for the intelligent evaluation module, the various units are combined and wrapped by a shell (9) of a gun-type structure. The air pump is located at the barrel of the gun-type structure. The infrared distance measuring sensor is placed below the air pump and connected to the indicator light. A control module is provided in the gun-type structure for receiving an output signal of the infrared distance measuring sensor and regulating the airflow output of the pressure air pump. The power supply is placed at the magazine of the gun-type structure. The switch is placed at the trigger of the gun-type structure. The advantages of the present invention are that an air pump that generates controllable air pressure is used to replace the traditional 10g nylon monofilament, thereby improving the success rate of pressure sensation detection of diabetic foot peripheral neuropathy, and the invention has a simple structure, can be reused, is easy to operate, and is convenient to use. The intelligent evaluation module is attached to evaluate the degree of peripheral neuropathy of the patient.

The invention provides an application of polylactic acid and a copolymer thereof in preparation of a medicine for promoting nerve growth and repairing, the molecular weight of the polylactic acid and the copolymer thereof is 400-300k Da, and the medicine has the following effects: 1) promoting growth of nerve cells and nerve tissues; 2) promoting the repair of nerve cells and nerve tissues; 3) treating or preventing peripheral nerve injury, spinal cord injury, peripheral neuropathy and neuritis; preferably, the molecular weight is in the range of 5000 to 100 k Da. The invention discovers that polylactic acid and the copolymer thereof have a protection effect on nerves for the first time, and can promote growth of the nerves and repair of nerve injury.

There is provided a transvenous cryoneurolysis system and method for accessing and targeting neural treatment sites to relieve a variety of clinical indications, including peripheral neuropathy. A neurosome approach is described that includes one or more target nerves to receive selective cryoneurolysis via a target vein. The system performs a variety of freeze-thaw cycles via the target vein to induce a desired axial cryolesion along a target nerve. The target nerves and veins are selected to combine the treatment of the identified neurosome for pain relief in addition to the regenerative properties of cryoneurolysis.

Compositions and methods are provided for the treatment or prevention of chemotherapy-induced peripheral neuropathy and hearing loss in a subject in need thereof. The methods involve administering to the subject a bclw protein, a BH4 domain-containing fragment thereof, or a bclw mimetic. Also provided are exemplary bclw mimetics.

The invention provides an application of gastrodin in preparation of a medicine for treating peripheral neuropathy. According to the application disclosed by the invention, gastrodin can inhibit neuroinflammation mediated by microglia by inhibiting activation of an NF-kB / NLRP3 inflammasome signal channel, so that release of inflammatory factors is reduced, and neuropathy induced by bortezomib is relieved.

To provide a biomarker, a diagnostic kit, and a method of assisting in diagnosis for the specific diagnosis of a group having specific disease state physiology in acute and chronic inflammatory demyelinating peripheral neuropathy with unknown autoantibody.SOLUTION: There are provided a biomarker, a diagnostic kit containing the same, and a method of assisting in diagnosis for using the same for diagnosis of inflammatory demyelinating polyneuropathy, including anti-LGI4 antibodies, or for determination of the efficacy of treatment, or the inflammatory demyelinating polyneuropathy being an autoimmune neuropathy.SELECTED DRAWING: None

The invention provides application of tea catechin in preparation of a medicine for preventing and treating bortezomib-induced peripheral neuropathy. A plurality of in-vitro model results show that tea catechin can be used as a copper death inhibitor, remarkably improves related indexes of bortezomib-induced peripheral neuropathy, improves survival rates of Schwanton cells and SH-SY5Y, improves mitochondrial functions and cell cycle abnormalities of the Schwanton cells, reduces intracellular copper ion, cuprous ion and ATP levels, and can be used for preparing the copper death inhibitor for the peripheral neuropathy of the Bortezomib-induced peripheral neuropathy of the Bortezomib-induced peripheral neuropathy. Meanwhile, the death of Schwann cells and SH-SY5Y induced by the copper death inducer is reduced. In-vivo experiments show that the tea catechin plays a role in protecting functional damage of the bortezomib, and the tea catechin remarkably improves mechanical hyperalgesia, gait abnormality and pathological changes of myelin sheath and axon of mice caused by peripheral neuropathy induced by the bortezomib. The tea catechin can be used as a medicine for peripheral neuropathy induced by bortezomib, and has high clinical application value and development prospect.

The present disclosure relates to compositions for increasing acetylated alpha-tubulin levels in peripheral neuronal cells. The present disclosure also relates to the use of tubulin deacetylase inhibitors, or activators of tubulin acetylation for increasing acetylated tubulin levels in the cells. The present disclosure also relates to methods for assessing risk of developing peripheral neuropathy by assessing the levels of acetylated alpha-tubulin. The present disclosure further relates to methods for treating a subject suffering from a peripheral neuropathy using the compositions described herein.

The application discloses an active polypeptide and application thereof in treating diabetic peripheral neuropathy, and belongs to the technical field of biological polypeptide drugs. An amino acid sequence of the active polypeptide is QVWPDGFVGLAKLWI, which is obtained by step-by-step enzymatic extraction and purification from Morus alba L. which is a homology of medicine and food. The polypeptide can significantly inhibit oxidative stress, inflammatory infiltration and cell apoptosis of Schwann cells induced by a high-sugar environment, and repair the function of damaged nerve cells. Meanwhile, the polypeptide can effectively improve abnormal sciatic nerve conduction function of a diabetic model mouse. The active polypeptide can be used for preparing a drug for treating diabetic peripheral neuropathy, and provides a new candidate drug and research and development direction for the targeted treatment of diabetic peripheral neuropathy.

The invention discloses a traditional Chinese medicine combination effective part capable of improving diabetic peripheral neuropathy. The traditional Chinese medicine combination effective part is prepared from a volatile oil effective part, a water-soluble effective part and an alcohol-soluble effective part, the effective part of the volatile oil comprises alpha-ocimene, alpha-santalene, bisabolol, beta-bisabolol and nerolidol; the water-soluble effective part comprises salvianolic acid A, salvianolic acid B and tanshinol; the alcohol-soluble effective part is prepared from Z-ligustilide, alpha-masticinic acid, beta-masticinic acid, tanshinone IIA, and 2-methoxy-5-acetyl-furangermacane-1 (10)-ene-6-ketone, and the alcohol-soluble effective part is prepared from the following raw materials in parts by weight: 2-methoxy-5-acetyl-furangermacane-1 (10)-ene-6-ketone. The traditional Chinese medicine composition effective part provided by the invention can regulate blood sugar, improve the conduction speed of sciatic nerves, repair damaged tissues, inhibit oxidative stress reaction, resist inflammation and relieve pain, so that the diabetic peripheral neuropathy is improved, the curative effect is reliable, the safety is good, the adverse reaction is low, and the traditional Chinese medicine composition effective part can be used for preparing a medicinal preparation for improving the diabetic peripheral neuropathy.

The invention discloses a nursing test method and system based on surgical glove pressurization, and the method comprises the steps: obtaining a plurality of test groups, each test group comprises a test group and a control group; pressurizing the test group based on a preset nursing mode to obtain test data of different time nodes; on the basis of the same environment, the control group is not subjected to any nursing, and control data of different time nodes are obtained; based on the same test group, performing comparative analysis on the test data and the contrast data of different time nodes to obtain an initial test result of the corresponding test group; traversing all the test groups to obtain an initial test result set, and comparing and analyzing initial test results in the initial test result set to obtain a test result. According to the method, non-drug intervention is adopted, through risk factor evaluation, personnel homogenization training and a surgical glove compression method, the accuracy of peripheral neuropathy testing is improved, and a scientific basis is provided for whether the surgical glove can replace a frozen glove or not.

The invention provides a traditional Chinese medicine preparation for treating peripheral neuropathy caused by chemotherapy, the traditional Chinese medicine preparation comprises an external preparation and an internal preparation, and discloses a preparation method and application of the traditional Chinese medicine preparation. The core pathogenesis of qi and blood stasis and yang deficiency and cold coagulation of the peripheral neuropathy caused by chemotherapy and the characteristic treatment method of tonifying qi and activating blood and warming yang and dredging collaterals are innovatively provided; the composition is rigorous and rigorous, and is clinically safe and effective.

The invention relates to a magnetic pulse treatment device for treating pain. The invention provides breakthrough equipment for patients suffering from foot pain, especially patients suffering from peripheral neuropathy. The main feature of the present invention is that a novel self-aligning applicator is employed to treat the entire foot at the same time without adjustment and sizing. By using segmented solenoids and placing the feet directly in their coherent magnetic core flux, a sufficiently large, sufficiently strong power treatment area can be achieved. The dosage of the whole foot can reach 2500 sigma delta BT within one hour. And the used voltage is extremely low, and the generated heat is extremely little, so that the equipment is suitable for household use.

According to the vibration sense testing device and method, a tested finger is stably supported through a testing support, the stability and accuracy in the measuring process are ensured, a physiological characteristic testing module can collect physiological parameter changes of a subject in the detecting process in real time, a vibration starting device can generate vibration stimulus of different intensities and frequencies, and the testing accuracy is improved. The test requirements of different vibration sensing thresholds are met, the reaction collection button can accurately capture reaction signals of a subject, the real-time performance and accuracy of a measurement result are ensured, the host control operation module allows setting of personalized measurement parameters so as to adapt to the requirements of different subjects, and the test efficiency is improved. By collecting and analyzing physiological parameters and reaction signals of a subject, the vibration intensity which can be sensed by finger parts of the subject can be comprehensively evaluated, powerful support is provided for personalized health monitoring and early discovery of peripheral neuropathy, the whole testing process is automatically controlled by a control host, the complexity of manual operation is reduced, and the testing efficiency is improved. And the test efficiency is improved.

The invention discloses an application of fenoterol hydrobromide and pharmaceutically acceptable salt thereof in preparation of a medicine for treating diabetic peripheral neuropathy. The fenoterol hydrobromide and the pharmaceutically acceptable salt thereof have obvious effects of promoting growth of peripheral sensory neurite and protecting myelin sheath injury, and can improve symptoms of slow nerve conduction speed and sensory deficiency induced by diabetes mellitus.

The present invention relates to a method and / or kit for diagnosing whether an individual suffers from peripheral neuropathy pain. The method comprises detecting advillin in a biological sample by detecting an immune complex formed by advillin and a monoclonal antibody that specifically binds thereto. The present invention also encompasses a method for treating an individual suffering from peripheral neuropathy pain.

The present invention discloses diagnostic and therapeutic markers for diabetic peripheral neuropathy and their applications. The diagnostic and therapeutic marker is eIF6. This invention, for the first time, discovers that upregulation of eIF6 in Schwann cells is closely associated with diabetic peripheral neuropathy. Targeted inhibition of eIF6 can effectively inhibit the progression of neuropathy, which is of great significance for the early diagnosis and treatment of diabetic peripheral neuropathy and for reversing the course of the disease. This invention develops a new method for diagnosing diabetic peripheral neuropathy and a new drug target for treating the disease.

The present invention provides a Chinese medicine composition having the function of significantly improving oxaliplatin-induced peripheral neuropathic pain, and a preparation method and application thereof. The Chinese medicine composition is composed of astragalus, cinnamon twig, white peony root, geranium, flue gastrodia elata, ginger, angelica, reed root, cypress leaf, motherwort, senecio, loofah, aloe, acanthopanax bark, jujube, curculigo orchioides, and sappan wood.