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483 results about "Angor pectoris" patented technology
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Chest pain caused by coronary heart disease
Soluble Guanylate Cyclase Activators
This inventions relates to compounds having the structure Formula Iand pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
Owner:MERCK SHARP & DOHME LLC
Soluble guanylate cyclase activators
A compound having the structureuseful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.
Owner:MERCK SHARP & DOHME CORP
Soluble guanylate cyclase activators
A compound having the structureuseful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.
Owner:MERCK SHARP & DOHME LLC
Soluble guanylate cyclase activators
The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
Owner:MERCK SHARP & DOHME LLC
Soluble guanylate cyclase activators
Owner:MERCK SHARP & DOHME LLC
Soluble guanylate cyclase activators
This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
Owner:MERCK SHARP & DOHME LLC
Therapeutic morpholino-substituted compounds
Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation. The compounds are useful in treating PI 3-kinase-dependent conditions including cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, vascular restenosis, atherosclerosis, and unstable angina; respiratory diseases such as asthma, chronic obstructive pulmonary diseases (COPD), and bronchitis; inflammatory disorders; neoplasms including cancers such as glioma, prostate cancer, small cell lung cancer, and breast cancer, and diseases linked to disordered white blood cell function, such as autoimmune and inflammatory diseases.
Owner:ASTRAZENECA AB
Pyrimidine 5-carboxamide compounds, process for producing the same and use thereof
Compounds of the formulawherein R1, R2, R3, R4, X and Y are as defined, which have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis, and the like; allergic diseases such as asthma, or disorders of male or female genital function and the like.
Owner:TAKEDA PHARMA CO LTD
Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
InactiveUS7727561B2Preventing cerebral agingEnhance memoryBiocideSugar derivativesRheumatismArthritis
Owner:PACIFIC ARROW
Preparation method of Radix Puerariae wine and product of Radix Puerariae wine
InactiveCN102604782AGood colorHigh clarityMicroorganism based processesAlcoholic beverage preparationAmylaseCoronary heart disease
The invention discloses a preparation method of Radix Puerariae wine. The preparation method comprises the following steps: collecting fresh Radix Puerariae, cleaning, cutting into pieces, adding water, and performing homogenate to obtain a Radix Puerariae homogenate liquid; sterilizing the Radix Puerariae homogenate liquid at 70-110 DEG C for 5-120 minutes, cooling to 50-65 DEG C, and regulatingthe pH value to 5-7 to obtain a sterilized solution; adding amylase into the sterilized solution until the mass percentage of the amylase is 0.01-5, performing enzymolysis at 50-90 DEG C for 0.5-24 hours, adding glucoamylase until the mass percentage of the glucoamylase is 0.01-5, and performing enzymolysis at 50-70 DEG C for 4-12 hours; then increasing the temperature to 70-110 DEG C, holding the temperature for 20-150 minutes, and cooling to 20-60 DEG C to obtain an enzymolysis solution; and finally adding saccharomyces cerevisiae into the enzymolysis solution until the mass percentage of the saccharomyces cerevisiae is 0.01-0.05, fermenting at 24-40 DEG C for 5-10 days, and filtering to obtain the Radix Puerariae wine. The preparation method is simple; and the prepared Radix Puerariae wine is high in Puerarin content and has an alcohol degree of 15-35, and can be applied to adjuvant therapy for diseases such as hypertension, angina pectoris, coronary heart disease, hyperlipidemia and the like.
Owner:SOUTHWEST UNIVERSITY
Preparation method of carbon grilled squid slices
ActiveCN103584188AReasonable processEasy to makeFood ingredient functionsFood preparationLiver and kidneyAngor pectoris
The invention relates to a preparation method of carbon grilled squid slices, which comprises the steps such as preprocessing of raw materials, primary flavoring and pickling, tenderization, injection, secondary flavoring and pickling, carbon grilling, stripping and packaging. The preparation method has the advantages of reasonable procedures, simple preparation and easy realization of scale production; the nutrition and the gold color of squids are retained; the special carbon grilled smell of marine products and the fresh lotus leaf scent are obtained; the meat quality is tender, properly sweet and salty, and delicious; raspberry juice is added in the squid slices for effectively relieving the cardiovascular diseases such as angor pectoris and achieving the effects of tonifying liver and kidney; the raspberry juice is added in flavoring liquid, so that appetites are satisfied after squid products are ate by human bodies, and more nutrition beneficial to the human bodies is absorbed. The squid slices prepared by the invention method are suitable for wide crowds such as children with weak teeth or the aged, and have the advantages of low cost, rich nutrition and long preservation time.
Owner:ZHEJIANG OCEAN UNIV
Fructus crataegi flaked candy and preparation method thereof
InactiveCN103478384AHas spleen and stomachDigestiveConfectionerySweetmeatsBiotechnologyCoronary heart disease
The invention relates to a fructus crataegi flaked candy and a preparation method of the fructus crataegi flaked candy. The flaked candy comprises, by weight, 1-40 pars of fructus crataegi powder, 5-30 parts of microcrystalline cellulose, 5-60 parts of sorbit, 5-30 parts of maltodextrin, 0.1-4 parts of lubricants and appropriate adhesion agents. Smashing, 80-mesh screening and even mixing are performed on the fructus crataegi powder and all the auxiliary materials, and then damp mass preparing, granulation, drying, granule arranging and flaking are performed to obtain the fructus crataegi candy. The fructus crataegi flaked candy has the functions of strengthening the spleen and stomach and aiding digestion, and has a certain therapeutic effect on high blood pressure, coronary disease, angor pectoris, hyperlipemia, stomachache, diarrhea and other diseases.
Owner:NANJING TONGZE AGRI SCI & TECH
High DNA type fatty ethyl ester in high purity, manufacturing method and preparation
ActiveCN101049297AHigh purityDistillation operating temperature is loweredOrganic active ingredientsMetabolism disorderMedicineFish oil
An ethylester of fatty acid containing high-content and-purity DHA and high-purity EPA, especially EPA-E and DHA-E in weight ratio of 1: (1.01-38), a medicine prepared from it for preventing and treating hyperlipemia, angina pectoris and cerebral infarction, and its preparing process are disclosed.
Owner:北京百慧生化制药有限责任公司
Endogenous repair factor production promoters
It relates to an endogenous repair factor production accelerator which comprises one or at least two selected from prostaglandin (PG) I2 agonist, EP2 agonist and EP4 agonist. Since prostaglandin (PG) I2 agonist, EP2 agonist or EP4 agonist has various endogenous repair factor production accelerating action, angiogenesis acceleration action and stem cell differentiation induction action, it is useful as preventive and / or therapeutic agents for ischemic organ diseases (e.g., arteriosclerosis obliterans, Buerger disease, Raynaud disease, myocardial infarction, angina pectoris, diabetic neuropathy, spinal canal stenosis, cerebrovascular accidents, cerebral infarction, pulmonary hypertension, bone fracture, Alzheimer disease, etc.) and various cell and organ diseases.
Owner:CUORIPS INC
Application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy
InactiveCN1565601AOpen up new application fieldsImprove medicinal effectNervous disorderAntipyreticDiseaseThrombus
The invention discloses an application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy, which can be used for treating vascular nerve cephalalgia, cerebral thrombus, cerebrovascular angiosclerosis, coronary heart diseases, angina pectoris, hypertension, or asomnia, or common cold, or women's dysmenorrheal.
Owner:SICHUAN HEZHENG PHARM CO LTD
Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method
The Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris consists of back lining material, medicine layer and protecting film. The medicine layer consists of skeleton supplementary material, effective Chinese medicine extractive and plasticizer; and the effective Chinese medicine extractive is ointment of extractive of Chuanxiong rhizome, sandalwood, nutagrass flatsedge rhizome, dalbergia wood, frankincense, kudzu vine root, etc. The Chinese medicine adhesive film is adhered to left chest for transdermal absorption to act on heart, and can dilate coronary blood vessel, improve blood flow of coronary blood vessel, improve heart function and prevent hidden coronary heart disease.
Owner:马德林
Polyethyleneglycol modified scutellarin compound and preparation thereof
InactiveCN101486744AImprove water solubilityImprove biological activityOrganic active ingredientsSugar derivativesSolubilityWater soluble
The invention discloses a PEGylated scutellarin compound and a preparation method thereof. The PEGylated scutellarin compound is as the shown formula (IV) and the PEGylated scutellarin compound can be applied to preparing medicaments applied to treating cerebral thrombosis, cerebral infarction, cerebral apoplexy, sequelaes caused by cerebral apoplexy, coronary heart disease or angina. Compared with the original scutellarin compound, the water solubility of the scutellarin compound is increased obviously; simultaneously, pharmacodynamics experiment on the mice model of cerebral ischemia-reperfusion shows that: compared with the original medicament, the biological activity of the scutellarin promedicament is strengthened obviously.
Owner:JIANGSU SIMCERE PHARMA +1
Gingko wine production process
InactiveCN101519629AShort production cycleHealth care functionAlcoholic beverage preparationCerebral vasospasmYeast
The invention relates to the preparation field of alcoholic beverage, in particular to gingko wine preparation with high health care component content, which is produced by taking deserted ginkgo biloba sarcotesta as the raw material, and adopting biological enzyme degrading pectic substance, cellulose, amylum, and other substances, and adopting the processes of wine yeast and natural grape fermentation or off-flavor alcohol infusing after enzyme destruction and defecation. The problems of foreign flavor and toxic component are simultaneously solved. The health care function of the gingko wine is more powerful than that of grape wine, the wine body is unique, the fruit aroma is stronger, the gingko wine is golden-colored and full of nutriments, with pure taste; and the gingko wine has the effects of dilating coronary arteries, enhancing blood flow, inhibiting blood coagulation, activating plasmin system, improving cardiotrophin, promoting cholesterin conversion, maintaining blood vessel elasticity, preventing and treating thromboembolia, coronary heart disease, angina pectoris, cerebral vasospasm and preventing cancer and restraining cancer, and the like. The gingko wine has remarkable economic benefit and social benefit.
Owner:徐琛
Pharmaceutical compositions of amlodipine and atorvastatin
InactiveCN1617717AMetabolism disorderInorganic non-active ingredientsPharmaceutical drugPharmaceutical medicine
Owner:WARNER LAMBERT CO LLC
Health care preparation for regulating functional balance of organs of bowels in human body and preparing method
InactiveCN1660387APrevent atherosclerosisEnhance metabolic functionUnknown materialsDrug compositionsDiseaseHuman body
A health-care food for preventing and treating atherosclerosis, hypercholesterolemia, hyperlipemia, hypertension, coronary heart disease, angina pectoris, tumor, etc, and balancing the functions of organs is prepared from 10 Chinese-medicinal materials including anemarrhena rhizome, ginger, wolfberry fruit, yam, etc.
Owner:韦平生
Preparation process of isosorbide mononitrate
InactiveCN1618798AHarsh reaction conditionsLow yieldOrganic chemistryCardiovascular disorderAnginaAcetic oxide
A process for preparing the isosorbide mononitrate from sorbitol includes dewatering sorbitol by p-methylphenyl sulfonic acid to obtain anhydrosorbitol, protecting by acetic oxide under existance of N,N-dimethylaminopyridine, nitrating by nitric acid / acetic oxide / acetic acid system, and removing protection by potassium carbonate-methanol system. It can be used to treat angina pectoris.
Owner:LUNAN PHARMA GROUP CORPORATION
Mailuo Ning oral liquid and its application in pharmacy
ActiveCN1557398AResolve Healing EffectsQuality improvementUnknown materialsCardiovascular disorderMedicinal herbsPharmacy
The present invention is Mailuoning oral liquid and its application in pharmaceutical. The Mailuoning oral liquid is prepared with four kinds of Chinese medicinal materials including achyranthes root, figwort, dendrobium stem and honeysuckle, and through water extraction, filtering, concentration; alcohol precipitation to obtain supernatant, recovering alcohol, concentration; alcohol precipitation to obtain supernatant, recovering alcohol, adding water, cold storage, filtering, adding corrective and co-solvent, regulating pH value, filtering, adding water into the filtrate, regulating solution concentration, packing and serilizing. The present invention also discloses the application of Mailuoning oral liquid in preparing medicine for preventing and treating angina pectoris. The medicine for preventing and treating angina pectoris has determined curative effect, lasting and mild effect and stable quality.
Owner:JINLING PHARMA
Traditional Chinese medicinal composition containing red sage root and haw and its preparation
ActiveCN101085071AOrganic active ingredientsMammal material medical ingredientsSalvia miltiorrhizaPolyethylene glycol
The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, haw thorn, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.
Owner:TIANJIN TASLY PHARMA CO LTD
Subing (quick effect heart rescue) spraying agent and its preparation method
InactiveCN102370673AAvoid Volatile DefectsPlay suitable forHydroxy compound active ingredientsAerosol deliveryNasal cavityAngina
The invention provides a novel traditional Chinese medicinal compound Subing (quick effect heart rescue) spraying agent and its preparation method and belongs to the field of biomedicine, wherein the Subing (quick effect heart rescue) spraying agent has a good curative effect of resisting coronary angina pectoris. The problem of dissolving borneol with levant storax oil is solved by a new technology and a new method. The prescription is composed of styrax, borneol, a solubiliser, an absorption enhancer and a solvent. By the simple new technology of dissolution, homogenization and the like, borneol which is completely insoluble in water and levant storax oil which is not miscible with water phase are dissolved together in an oral water-soluble base so as to obtain an oral solution which is uniform and transparent without layers and suspension. The spraying agent or aerosol prepared in the invention can be quantitatively and directly sprayed into mouth or sprayed under tongue or directly sprayed into nasal cavity. In comparison with a solid preparation, the spraying agent prepared by styrax and borneol for oral administration has advantages of fast absorption and rapid effect, can perform a curative effect better and faster, is applicable to be taken by patients with angina pectoris during the acute phase. By the adoption of the preparation method provided by the invention, the effect onset time is greatly shortened within 60 seconds. The preparation method provides a good therapeutic novel medicine for currently high frequency and high occurrence of heart disease in our country.
Owner:王登之
Acer truncatum leaves health bagged tea and preparation technique thereof
InactiveCN102648727ASimple recipeSimple preparation processPre-extraction tea treatmentCholagoguesChlorogenic acid
The invention discloses an acer truncatum leaves health bagged tea, which comprises acer truncatum leaves, plateau greenleaf tea and semen cassiae, and is prepared through the steps of washing, spreading out for drying, water removing with vapor, kneading, drying, mixing and grinding, granulating, bagging, packaging and the like. By utilizing active substances which are rich in flavone, chlorogenic acid, tannin, cardiac glycosides and the like, health pharmacological active ingredients are not damaged, and the acer truncatum leaves health bagged tea can be used for treating and preventing coronary heart disease, angina pectoris, blood circulation disabled diseases and cardiovascular diseases and has actions of virus resistance, deflammation, cholagogue, removal of free radical of the human body, removal of liver heat, improvement of eyesight and the like.
Owner:李小英
Cyclopropanecarboxylic acid derivative
InactiveUS20130012532A1High activityGood characterAntibacterial agentsBiocidePulmonary artery embolismHydrogen atom
A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein R1 represents a C1 to C6 alkyl group which may be substituted by one to three groups selected from substituent group A, or the like (substituent group A: a hydroxy group, a halogeno group, a cyano group, a nitro group, an amino group, a carboxy group, a C1 to C3 alkyl group, etc.); R2, R3, and R8 each independently represent a hydrogen atom or a C1 to C3 alkyl group; R4, R5, R6, R7, R9, and R10 each independently represent a hydrogen atom or the like; and R11 represents a hydrogen atom or the like, has TAFIa enzyme inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, or the like.
Owner:DAIICHI SANKYO CO LTD
Composition containing candesartan and amlodipine, preparation process, testing process and application thereof
ActiveCN102670604AUnique formulaReduce manufacturing costOrganic active ingredientsComponent separationCandesartanAngina
The invention relates to a composition and a preparation process, a testing process and an application thereof. The composition comprises a therapeutically effective amount of candesartan or pharmaceutically acceptable ester or salt, a therapeutically effective amount of amlodipine or other pharmaceutically acceptable salt, 70-150 parts of mannitol or lactose, 2-5 parts of croscarmellose sodium or cross-calcium carboxymethyl cellulose and 5-40 parts of microcrystalline cellulose or corn starch. The composition is easy to prepare, low in production cost, utilizes accessories of unique prescription, and the like, can be prepared into oral preparation in forms of tablets, capsules, granules and the like by means of pharmaceutics, can be checked by different checking processes, has high quality, has functions of treating hypertension, angina pectoris and kidney diseases and has effect of myocardial protection.
Owner:SICHUAN SUNNYHOPE PHARM CO LTD
Compound ginkgo leaf reparation and its making method
ActiveCN1513541AIncrease contentQuality improvementOrganic active ingredientsUnknown materialsCoronary artery diseaseAngina
A Chinese medicine for preventing and treating coronary heart disease and angina pectoris, and protecitng the cerebral ischemic injury is prepared from ginkgo leaf extract, ginseng extract, and the volatile oil of chuan-xiong or borneol.
Owner:天津金士力健康用品有限公司
Preparation, quality control method and application of composition of active ingredients of bitter herb
ActiveCN102362883AHigh yieldLow cost of water extractionComponent separationCardiovascular disorderMedicinal herbsPolyamide
The invention discloses a preparation method, a quality control method and an application of composition of active ingredients ob bitter herb. The composition of the active ingredients of the bitter herb disclosed by the invention mainly comprises cichoric acid and luteolin-7-O-beta-D-glucuronide, and content of the cichoric acid and the luteolin-7-O-beta-D-glucuronide is not less than 80%. An extraction method of the composition comprises that pretreatment is carried out by adopting an enzymatic method, then a supercritical fluid extraction method is adopted, and the obtained extract is respectively subjected to separating, purifying, concentrating and drying by virtue of an AB-8 resin column and a polyamide resin column so as to obtain the composition. Besides, the invention also relates to an application of the composition in preparation of modern bitter herb injection and treatment on coronary heart disease, angor pectoris, myocardial infarction and cerebral infarction and an application of the composition in content determination of the composition of the active ingredients of the bitter herb and quality control of bitter herb medicinal material.
Owner:沈阳双鼎制药有限公司
Cockroach extractive for treating cardiovascular disease, preparation method and its composition
InactiveCN101156875AHigh content of active ingredientsActive ingredient content hasAnthropod material medical ingredientsPharmaceutical delivery mechanismVascular diseaseAlcohol
The invention relates to extractive taking blattaria used as the medical source and being applied to the angiocarpy field, the preparation method thereof and a composition containing the extractive and pharmaceutically acceptable carrier. The extractive adopts water, alcohol and / or methanol as the extracting dissolvent, wherein, the volume concentration of the aqueous solution of the alcohol and / or methanol is 0 less than or equal to V / V less than or equal to 60 percent. The extractive has the advantages that blood fat is reduced, cholesterin is reduced, angina pectoris is prevented, the heart is tonified, and heart failure is resisted. The extraction process of the invention is simple and highly effective, the specialization is strong, and the obtained product has high effective component content. The extractive of the invention can be produced to be the composition containing the extractive and the pharmaceutically acceptable carrier.
Owner:SHENZHEN SALUBRIS PHARMA CO LTD
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