46 results about "Angor pectoris" patented technology

The invention belongs to the field of biological medicine industry, and discloses a peripheral blood marker and system for identifying the severity of viral myocarditis or coronary artery stenosis. The inventor finds for the first time that the average value of LRG1 in blood is not obviously changed compared with that of a normal person when mild and moderate myocarditis and microcirculation angina pectoris with normal coronary artery or coronary artery stenosis smaller than 10% exist, and the blood LRG1 is obviously increased when the coronary artery stenosis of the coronary heart disease exceeds 70%; when severe myocarditis occurs, the blood LRG1 is also obviously increased, so that the increase of the blood LRG1 is a blood marker for patients with severe myocarditis or severe coronary artery lesion, and the blank that blood indexes are lacked in the prior art to prompt the patients to have severe coronary artery stenosis is filled. By detecting the LRG1 content of the peripheral blood and combining with other conventional examinations, the severity of myocarditis or coronary stenosis can be simply, accurately and quickly distinguished, and a corresponding basis is provided for subsequent accurate treatment.

The invention relates to the field of pharmacy, and provides a crystal form B of a compound cis-(+)-5-[(2-dimethylamino) ethyl]-2-(4-methoxyphenyl)-3-acetoxy-2, 3-dihydro-1, 5-benzothiaza # imgabs0 #-4 (5H)-ketone hydrochloride, which can meet the pharmaceutical requirements of convenient production, processing, transportation, storage and the like. The invention also relates to a preparation method of the crystal form B of the compound, a raw material medicine containing the crystal form B, a composition containing the crystal form B and application of the crystal form B in preparation of medicines for treating angina pectoris, hypertension, coronary heart disease and / or arrhythmia.

The invention relates to a crystal form of a compound shown as a formula I or a pharmaceutically acceptable salt thereof and a preparation method of the crystal form of the compound shown as the formula I or the pharmaceutically acceptable salt thereof. The compound of the formula I or the pharmaceutically acceptable salt thereof is used for treating cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary arterial hypertension (WHO levels I, II, III, IV), angina pectoris, thrombus, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hyperplasia, erectile dysfunction, asthma, chronic kidney disease, diabetes, and the like. The composition can be used for treating liver cirrhosis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis or interstitial lung disease.

The present application belongs to the technical field of pharmaceutical preparation, and provides a quick-dissolving nicorandil tablet and a preparation method thereof. The tablet is composed of an active ingredient nicorandil, hydroxypropyl methylcellulose acetate stearate, maltodextrin powder, a disintegrating agent and a lubricant. The product of the present application has good performances in moisture and heat stability and dissolution rate. In particular, the dissolution rate still has the performance of quick dissolution after accelerated investigation, which is beneficial to the emergency treatment of angina pectoris.

A traditional Chinese medicine formula for treating blood vessel clogging belongs to the field of traditional Chinese medicine formulas, and comprises the following main raw materials: 29-31 parts of black pearl, 11-13 parts of codonopsis pilosula, 7-9 parts of saffron crocus, 8-10 parts of angelica sinensis, 190-210 parts of leek, 9-11 parts of pseudo-ginseng, 37-43 parts of hawthorn, 95-105 parts of astragalus membranaceus, 18-22 parts of kudzu vine root, 8-10 parts of peach kernel, 8-10 parts of prepared rehmannia root, 9-11 parts of radix rehmanniae, 11-13 parts of white paeony root, 3 parts of red ginseng, 9-11 parts of radix ophiopogonis, 14-16 parts of spina date seed, 11-13 parts of Chinese yam, 14-15 parts of schisandra chinensis, 9-11 parts of polygonum multiflorum, 7-9 parts of cinnamon, 18-21 , 13-15 parts of anise and 12-14 parts of rhizoma polygonati. The traditional Chinese medicine composition has an obvious improvement effect on coronary artery insufficiency, myocardial ischemia, mitral valve, tricuspid valve, aortic valve regurgitation, chronic heart failure, patients needing operation bypass stenting, angina pectoris, myocardial infarction sequelae, cerebral ischemia, cerebrovascular sequelae and other symptoms caused by cardiac insufficiency, the dosage is small, the effect is fast, the cure rate is high, relapse is not prone to occurring, and the traditional Chinese medicine composition is suitable for clinical application. The effects of tonifying qi and activating blood, dredging channels and relieving pain, eliminating phlegm and removing blood stasis, tonifying heart and soothing nerves and the like can be achieved.

The invention discloses a medicine for treating the heart of a human body, and particularly relates to the field of medicines, the medicine is prepared from the following components in percentage by mass: 13.8% of radix salviae miltiorrhizae, 4.1% of allium macrostemon, 8.3% of semen trichosanthis, 2% of polygala tenuifolia, 8.3% of radix ophiopogonis, 2% of sandalwood, 6.9% of pericarpium citri reticulatae viride, 13.8% of lily, 8.3% of semen boitae, 10.4% of poria cocos, 8.3% of oriental cherry powder and 13.8% of earthworm, and the sum of the mass percentages of the components is 100%. According to the medicine for treating the heart of the human body, traditional Chinese medicine decoction pieces such as salvia miltiorrhiza, allium macrostemon, snakegourd seeds, polygala tenuifolia, radix ophiopogonis, sandalwood, pericarpium citri reticulatae viride, lily, platycladi seeds, poria cocos, oriental cherry powder and lumbricus are crushed and proportioned according to corresponding formula proportions and processes, so that the medicine plays the maximum effects of all the decoction pieces, is easier to take and absorb, and can be taken for a long time after being taken. The traditional Chinese medicine composition has obvious treatment effects on cardiac insufficiency, dyspnea, weakness, fatigue, angina pectoris, palpitation, palpitation and other problems caused by heart problems of heart disease patients, and can effectively treat coronary heart disease, myocardial ischemia, arrhythmia and other heart diseases.

A traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof belong to the field of traditional Chinese medicines. The traditional Chinese medicine composition for treating cardiovascular diseases is prepared from tribulus terrestris, salvia miltiorrhiza, pseudo-ginseng, ligusticum wallichii, astragalus membranaceus, angelica sinensis, immature bitter orange, sandalwood and honey-fried licorice root. The method comprises the following steps: 1, weighing; 2, preparing sandalwood volatile oil; 3, preparing a water extract; and 4, mixing. The traditional Chinese medicine composition has the advantages that (1) multi-target cooperation is realized: the traditional Chinese medicine composition simultaneously acts on three levels of a blood coagulation system, vascular endothelium and myocardial cells, has the functions of activating blood, tonifying qi and regulating qi, and is more comprehensive than a single blood activating formula; (2) treating both symptoms and root causes: improving the symptoms (the effective rate of angina pectoris is 92%) and delaying the pathological progress; (3) high safety: high safety, suitability for long-term administration, no bleeding tendency (APTT is maintained in a normal range) after long-term administration, and wide market prospect; the tribulus terrestris has an antihypertensive effect and is especially suitable for patients with hypertension and coronary heart disease.

The present application belongs to the technical field of medicine, and relates to derivatives of carboxylic acid groups introduced by 10-position hydroxyl in the structure of ginkgolide B and ester derivatives of the carboxylic acid groups, and pharmaceutically acceptable organic or inorganic salts, as shown in formula 1 and formula 2. The present application takes ginkgolide B as a matrix, and is chemically modified to improve the solubility, increase the bioavailability, and enhance the curative effect of ginkgolide B. The prepared compound and carboxylic acid salt thereof have significant platelet activating factor antagonism, anticoagulation effect, and acute cerebral ischemia effect, and can be used for preparing medicines for preventing and treating ischemic stroke, thrombosis, angina pectoris, cardiopulmonary infarction, and diseases related to platelet activating factor, such as inflammation, asthma, and the like.

The present application belongs to the technical field of sports rehabilitation, and aims at the technical problem that the current expert consensus is mainly to guide the patients after interventional therapy to carry out cardiac rehabilitation, and the population is not defined on the patients with angina after PCI, so the guidance of sports rehabilitation treatment is not accurate, and there is currently a lack of cardiac rehabilitation guidance technology for such patients. The present application adopts one-stop load myocardial perfusion technology, and combines cardiopulmonary exercise test to evaluate the cardiopulmonary function of the patient and formulate the exercise intensity. On the basis of the cardiopulmonary exercise test data and the clinical data of the patient, the transmural index of myocardial perfusion, a semi-quantitative index, is used to grade the microcirculation disorder, and the exercise intensity scheme of the patient is adjusted on this basis. After the evaluation of the present application by myocardial perfusion, the patient is given higher intensity training, and the degree of increase of VO2 is significantly improved compared with the traditional rehabilitation scheme.

The present invention provides a compound having a PDHK inhibitory activity and useful for the treatment or prophylaxis of diabetes (type 1 diabetes, type 2 diabetes etc.), insulin resistance syndrome, metabolic syndrome, hyperglycemia, hyperlactacidemia, diabetic complications (diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, cataract etc.), cardiac failure (acute cardiac failure, chronic cardiac failure), cardiomyopathy, myocardial ischemia, myocardial infarction, angina pectoris, dyslipidemia, atherosclerosis, peripheral arterial disease, intermittent claudication, chronic obstructive pulmonary disease, brain ischemia, cerebral apoplexy, mitochondrial disease, mitochondrial encephalomyopathy, cancer, pulmonary hypertension or Alzheimer disease. The present invention relates to a compound of the formula [I-a] or the formula [II], or a pharmaceutically acceptable salt thereof:wherein each symbol means the same as that described in the specification.

The present invention discloses a portable drug storage device for angina pectoris, specifically relating to the technical field related to drug storage devices, comprising a base, the lower portion of the base being provided with a restraining strap for tying the device to a patient's arm, the upper end of the base being provided with a storage mechanism, the storage mechanism comprising four storage boxes, the inner middle side of the storage box being provided with a baffle, the baffle separating the storage box into a rectangular frame located on the left side of the storage box and an arc-shaped frame located on the right side of the storage box. The portable drug storage device for angina pectoris described in the present invention, by configuring the storage mechanism to be composed of a plurality of storage boxes, allows each pill to be stored separately, thereby preventing some pills from frequently coming into contact with the outside world, thereby extending the storage time of the medicine. In addition, by providing structures such as a V-shaped control panel, a cover plate, and a support plate, the patient can operate the device with one hand, thereby preventing the patient from being unable to take medicine in time when the disease occurs, causing the patient to suffer greater pain.

The invention provides a prediction tool for auxiliary diagnosis of coronary heart disease through combination of traditional Chinese medicine and western medicine and a score table, particularly relates to a coronary heart disease noninvasive auxiliary diagnosis score table based on four diagnosis information of traditional Chinese medicine, and belongs to the technical field of medical diagnosis. The method focuses on a non-invasive prediction model of the coronary heart disease for the first time, and solves the problems of strong invasiveness and unintegration of traditional Chinese medicine characteristics in the prior art. Core predictive variables are screened by collecting four diagnosis information (including intraocular angular blood vessel thickening, blood stasis expression and other traditional Chinese medicine sign characteristic clinical expressions) of coronary heart disease patients, and a Logistic regression model is constructed and converted into a score table. The scale comprises indexes such as age, combined diseases, typical angina pectoris, abnormal angular blood collaterals in eyes, blood stasis and kidney deficiency, and the coronary heart disease is diagnosed when the total score is greater than or equal to 4. According to the method, the model for predicting the coronary heart disease is constructed by utilizing a statistical method, and the model is converted into the score table which is easy to operate through the statistical method, so that clinical popularization and application are facilitated, doctors are assisted to make accurate and efficient clinical decisions, and clinical doctors are guided to make accurate and effective treatment schemes.

The application discloses a kind of intelligent diagnosis and decision support method of coronary heart disease angina TCM syndrome factor based on HIS, it is related to medical information and TCM diagnosis and treatment technical field, the method will coronary heart disease angina TCM syndrome factor diagnostic criteria be deconstructed into standardization diagnostic item, build machine-readable weight rule base containing score, threshold and severity grading rule, response syndrome differentiation operation generates electronic collection form, receives structured data storage to the TCM syndrome factor fact table associated with patient main index and medical record, after structured data is submitted, trigger intelligent computing engine verification essential item, total score is accumulated, determine the establishment of syndrome factor and severity, through TCM diagnosis and treatment knowledge graph push personalized treatment or nursing suggestion in clinical business node, and continuously update rule base and knowledge graph through clinical data feedback.The application integrates corresponding function module to realize and deeply fuse with hospital information system, improves the standardization and efficiency of diagnosis and treatment, and has strong practicality.

The invention belongs to the technical field of exercise rehabilitation, and aims to solve the problems that at present, expert consensus is mainly used for guiding patients after interventional therapy to perform heart rehabilitation, people are not defined on patients suffering from angina pectoris after PCI (Peripheral Component Interconnect), so that the guidance of the patients on exercise rehabilitation is inaccurate, and the rehabilitation effect is poor. In order to solve the technical problems in the prior art that heart rehabilitation guidance for the patients is lacked at present, a one-stop load myocardial perfusion technology is adopted, cardiopulmonary function evaluation is performed on the patients and exercise intensity is formulated in combination with cardiopulmonary exercise tests, and on the basis of cardiopulmonary exercise test data and clinical data of the patients, the cardiopulmonary exercise intensity is formulated. The microcirculation disturbance is graded by adopting a semi-quantitative index, namely a myocardial perfusion transmural index, and the exercise intensity scheme of a patient is adjusted on this basis. After myocardial perfusion is adopted for evaluation, higher-intensity training is provided for a patient, and the VO2 rising degree is remarkably improved compared with a traditional rehabilitation scheme.

The purpose of the present disclosure is to provide a coated stent for coronary arteries, which enables effective treatment of coronary artery perforations that may occur during procedures such as those for angina pectoris and myocardial infarction. The coated stent for coronary arteries according to the present disclosure can prevent restenosis after implantation and provides enhanced in vivo stability due to reduced detachment force.

The invention discloses an exercise rehabilitation system and method for a PCI postoperative angina pectoris patient, and relates to the technical field of exercise rehabilitation, and the system comprises a perfusion scanning module which is used for carrying out cardiac coronary artery imaging and myocardial perfusion scanning on the patient, and obtaining a myocardial perfusion index of the patient; the danger layering module is used for carrying out danger layering on patients according to myocardial perfusion indexes; the scheme making module is used for making an exercise rehabilitation scheme according to the danger layering result; the data feedback module is used for monitoring the exercise intensity and the heart rate of the patient in the exercise rehabilitation process and adjusting the exercise rehabilitation scheme according to the monitored data. According to the technical scheme, the reason of angina pectoris attack of the patient can be determined, theoretical guidance is provided for further exercise rehabilitation, and the method has high application value.

The present invention relates to the technical field of medicine, and to derivatives represented by formula 1 and formula 2 in which a carboxylic acid group is introduced into the structure of Ginkgolide B by means of a hydroxyl group at the 10-position and ester derivatives of carboxylic acid groups, and pharmaceutically acceptable organic or inorganic salts. Ginkgolide B is used as a parent body and is prepared by means of chemical structure modification so as to achieve the goals of improving solubility, increasing bioavailability and enhancing healing efficacy. The prepared compound and carboxylate salts thereof have significant platelet activating factor antagonism, an anticoagulant effect and an anti-acute cerebral ischemia effect, and can be used for preparing a drug for preventing and treating ischemic stroke, thrombosis, angina pectoris, cardiopulmonary infarction, as well as inflammation, asthma and other diseases related to a platelet activating factor.

The application discloses an angina pectoris relieving treatment device for old cardiovascular internal medicine, and relates to the technical field of medical care, which comprises a thimble, a chassis, a pressing column, a first spring and a pressing frame, the chassis is rotationally connected with symmetrically arranged thimbles, the two thimbles are fixed through a snap pin, the chassis is slidably connected with the pressing column, the pressing column is provided with the pressing frame, and the first spring is connected between the pressing column and the chassis. The two thimbles can be worn on the wrists of patients with light symptoms, the pressing column is pressed, the pressing column and the pressing frame massage the neiguan acupoint of the patient to relieve pain, and the pressing column and the pressing frame can also be attached to the chest of patients with severe symptoms to massage the chest of the patient and relieve pain.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a healthy energy supporting, yang warming and meridian dredging paste which is technically characterized by being prepared from honey-fried ephedra, wine-processed cornus, safflower, red paeony root, stevia rebaudiana, prepared common monkshood daughter root, Chinese yam, kudzuvine root, prepared rhizome of rehmannia, platycodon grandiflorum, pollen typhae, ligusticum wallichii, angelica sinensis, radix achyranthis bidentatae, astragalus membranaceus, asarum, radix bupleuri, liquorice, peach kernel, lignum dalbergiae odoriferae and fructus aurantii according to a specific weight part ratio. According to the ointment formula, the theory of Zheng method of Yandezhi teaching professor and the experience of Radix Astragali-Radix Puerariae formula of Guizhongguang national medicine master are fused, a treatment system which warms yang, benefits qi, promotes blood circulation, removes blood stasis, strengthens the body resistance and dredges collaterals is established, and the ointment formula accurately aims at the core pathogenesis of yang deficiency and blood stasis type coronary heart disease angina pectoris and chronic heart failure. Clinical tests prove that the ointment is remarkably superior to conventional treatment (Plt; 0.05) in the aspects of improving traditional Chinese medicine syndromes and improving heart functions, and is good in safety; moreover, the preparation is an oral ointment, is moist and sweet in quality, is convenient to take for a long time, and has remarkable clinical application value and popularization prospect.

The present invention relates to a novel extended release composition of trimetazidine or salt thereof in the form of pellet which are prepared by matrix technology in the treatment of angina pectoris. The pellet according to present invention are prepared by matrix technology comprising one or more extended release polymers along with one or more pharmaceutically acceptable excipients.

The invention relates to the technical field of medical instruments, and discloses a stenocardia relieving treatment device for the cardiovascular medicine department, the stenocardia relieving treatment device comprises a clamping seat, a lifting frame and a relieving mechanism, the clamping seat is clamped and fixed with a bed body through cooperation of a threaded rod and a locking sleeve, the lifting frame comprises a supporting frame, a second lead screw and a second motor, and the vertical position of the relieving mechanism is adjusted. A support of the relieving mechanism adjusts the transverse position of a massage disc through a first lead screw and a sliding block, an electric telescopic rod and a guide rod of a driving part drive the massage disc to move in the length direction of the bed body, and flexible massage is achieved in cooperation with a telescopic column and a spring. The massage disc is in a concave arc shape and provided with massage balls, and a medicine storage box on the massage disc supplies medicine to the spraying opening under the control of an electromagnetic valve. Multi-degree-of-freedom accurate positioning is achieved, angina pectoris is relieved through the synergistic effect of mechanical massage and medicine transdermal, operation is convenient and fast, and treatment stability is high.

The application belongs to the field of pharmaceutical chemistry, and particularly relates to a cyclovirobuxin D derivative structural formula (I) or formula (Ia) compound, a preparation method and application. Experimental results show that the structural formula (I) or formula (Ia) compound has different degrees of hypoxia tolerance and ischemia capacity, and therefore the above-mentioned compound can be used as a drug for preventing or treating cardiovascular and cerebrovascular diseases, and has potential for treating cardiovascular and cerebrovascular diseases. The cardiovascular and cerebrovascular diseases include but are not limited to angina pectoris, arrhythmia, hypertension, hyperlipidemia and ischemic stroke.

The application belongs to the technical field of medicine, and particularly relates to application of acacetin or 6-hydroxyflavone in preparation of anti-angina pectoris drugs, and aims to solve the problems of adverse reactions such as blood pressure drop, reflex tachycardia and the like caused by non-selective vasodilation of existing anti-angina pectoris drugs, wherein the drug improves myocardial blood supply by selectively dilating coronary vessels of the heart, wherein acacetin dilates coronary vessels of the heart by inhibiting cardiac coronary vessel myosin light chain kinase and activating myosin light chain phosphatase, and 6-hydroxyflavone dilates coronary vessels of the heart by inhibiting protein kinase C and enhancing myosin light chain phosphatase activity; and the acacetin or 6-hydroxyflavone significantly reduces the symptoms of myocardial ischemia of rats caused by isopropyl adrenaline, improves characteristic ECG abnormal changes of angina pectoris, does not affect heart rate and systemic blood pressure, and is safer, thereby providing a potential drug selection for anti-angina pectoris treatment.

The invention relates to the field of cardiovascular disease treatment, in particular to a traditional Chinese medicine composition for improving heart health and a preparation method thereof. The traditional Chinese medicine composition is characterized by comprising twenty traditional Chinese medicines including 5 to 20g of radix salviae miltiorrhizae, 5 to 15g of flos carthami, 5 to 15g of radix paeoniae rubra, 5 to 15g of frankincense, 5 to 15g of myrrh, 5 to 15g of radix notoginseng, 3 to 10g of clove, 5 to 15g of radix aucklandiae, 3 to 10g of agilawood, 5 to 15g of sandalwood, 3 to 10g of storax, 5 to 15g of rhizoma corydalis, 5 to 15g of ligusticum wallichii, 3 to 15g of schisandra chinensis, 3 to 15g of borneol, 500ml of olive oil and the like, and any one or any combination of 5 to 15g of radix codonopsis, 5 to 15g of radix ophiopogonis and 5 to 15g of lignum dalbergiae odoriferae is contained in the formula. The medicine can be quickly absorbed by smelling the medicine, directly enters blood, and is suitable for relieving acute angina pectoris, chest distress and shortness of breath. The health-care tea is an ideal heart health improving product, and is especially suitable for people with coronary heart disease history or high risk of cardiovascular diseases.

The present application relates to a kind of traditional Chinese medicine composition for treating coronary atherosclerotic disease stable angina, the traditional Chinese medicine composition is made of the following weight parts of raw medicinal materials: Radix Bupleuri 10-14 parts, Ramulus Cinnamomi 3-7 parts, Herba Agrimoniae 13-17 parts, Salvia Miltiorrhiza 13-17 parts, Radix Paeoniae Alba 3-7 parts, Rhizoma Pinelliae Praeparatum 4-8 parts, Radix Scophularae 3-7 parts, Radix Ginseng 3-7 parts, Radix Glycyrrhizae 1-5 parts, Zingiber officinale 3-7 parts, Fructus Jujubae 4-8 parts.The present application also provides the application of traditional Chinese medicine composition in the preparation of medicine for treating coronary atherosclerotic disease stable angina.The treatment principle of the present application is: regulating liver and unblocking yang, regulating qi and activating blood.The drugs in the present application are used together, and the effect is enhanced, can regulate Ying and Wei, regulate liver qi, unblock chest yang, and unblock blood vessels, so as to achieve the effect of preventing and treating stable angina pectoris of coronary heart disease.The present application can effectively improve the angina pectoris symptoms of patients with stable angina pectoris of coronary heart disease, improve the quality of life of patients, has certain clinical value, and is worth further research and promotion.

This invention discloses a multifunctionalized pyridine compound, its preparation method, and its applications, belonging to the fields of pharmaceutical intermediates and organic synthesis. The invention uses α-allyl-p-toluenesulfonylmethylene isonitrile and substance A as raw materials, and a free radical cyclization reaction is carried out under the action of a catalyst to obtain a highly functionalized pyridine compound, as shown in formula (Ⅰ). Substance A is phenylboronic acid, cyclohexylboronic acid, [1,1'-biphenyl]-4-boronic acid, p-methylphenylboronic acid, m-methylphenylboronic acid, o-methylphenylboronic acid, p-cyanophenylboronic acid, thiophene-3-boronic acid, or cyclopropylboronic acid. The method of this invention not only has very broad substrate tolerance, inexpensive and readily available raw materials, and a simple reaction process suitable for large-scale synthesis, but also provides a new method for pharmaceutical chemical synthesis. Furthermore, due to the high functionalization and special structure of the pyridine compound, it exhibits better efficacy in treating chronic stable angina pectoris, central respiratory depression and circulatory failure, and in the treatment of various organoiodinated phosphate poisonings.

The invention relates to new indications of a traditional Chinese medicine preparation containing mulberry leaves. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicinal materials in parts by weight: 12 parts of mulberry leaves, 12 parts of lotus leaves, 12 parts of hawthorn leaves, 15 parts of salvia miltiorrhiza and 15 parts of red peony roots. The invention aims to provide a new clinical application of the medicine for treating metabolic related fatty liver diseases, non-alcoholic fatty liver diseases, hyperlipidemia, cerebral infarction, coronary heart disease, angina pectoris and the like, so that the clinical application indication range of the medicine is expanded, and more medication choices are provided for clinical patients.

The invention discloses an intelligent auxiliary diagnosis system and method for unstable angina pectoris based on a biomarker RETN, and belongs to the technical field of biological medicine. According to the present invention, the Olink high-throughput proteomics technology screening finds that the expression of RETN and other proteins in the UA patient serum is up-regulated, and after the ELISA verification, the RETN and other proteins are combined with the clinical conventional indexes, and the machine learning algorithm is adopted to construct the multi-dimensional diagnosis system; the prediction module adopts a double-layer architecture, a base module layer parallelly runs six algorithms to capture a nonlinear relationship, a meta module layer adopts logistic regression secondary modeling, and the generalization ability is improved. The system and the method can realize accurate recognition and dynamic monitoring of UA early lesion, break through the bottleneck of traditional detection, make up for the defect of insufficient specificity, and overcome the limitation of incapability of repeated monitoring. The AUC of the diagnosis model in an independent verification queue reaches 0.842 or above, the accuracy rate exceeds 76%, UA patients can be screened, the coronary artery stenosis degree can be evaluated, and personalized treatment can be assisted.

The invention discloses a drug-loaded hydrogel ball as well as a preparation method and application thereof. The drug-loaded hydrogel ball comprises a hydrogel matrix and loaded propranolol hydrochloride, wherein the hydrogel matrix comprises a cross-linked network formed by cross-linking sodium carboxymethyl cellulose and iron ions, a cross-linked network formed by cross-linking water chestnut starch and iron ions, and zinc oxide nanoparticles. The drug-loaded hydrogel ball has the advantages of being excellent in targeted slow release performance, high in antibacterial activity, good in biocompatibility, high in drug loading capacity, good in stability, green, degradable and the like, can be used for long-acting drug treatment of cardiovascular diseases such as hypertension and angina pectoris, and is simple in preparation process, low in production cost and suitable for large-scale industrial production and application.

A traditional Chinese medicine formula for improving blood vessel clogging symptom belongs to the field of traditional Chinese medicine formulas, and comprises the following main raw materials: 29-31 parts of black pearl, 11-13 parts of codonopsis pilosula, 7-9 parts of saffron crocus, 8-10 parts of angelica sinensis, 190-210 parts of leek, 9-11 parts of pseudo-ginseng, 37-43 parts of hawthorn, 95-105 parts of astragalus membranaceus, 18-22 parts of kudzu vine root, 8-10 parts of peach kernel, 8-10 parts of prepared rehmannia root, 9-11 parts of radix rehmanniae, 11-13 parts of white paeony root, 3 parts of red ginseng, 9-11 parts of radix ophiopogonis, 14-16 parts of spina date seed and 11-13 parts of Chinese yam. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 14-15 parts of schisandra chinensis, 9-11 parts of polygonum multiflorum, 7-9 parts of cinnamon, 18-21 parts of semen cuscutae, 18-21 parts of semen coicis, 13-15 parts of anise and 12-14 parts of rhizoma polygonati. The traditional Chinese medicine composition has an obvious improvement effect on coronary artery insufficiency, myocardial ischemia, mitral valve, tricuspid valve, aortic valve regurgitation, chronic heart failure, patients needing operation bypass stenting, angina pectoris, myocardial infarction sequelae, cerebral ischemia, cerebrovascular sequelae and other symptoms caused by cardiac insufficiency, the dosage is small, the effect is fast, the cure rate is high, relapse is not prone to occurring, and the traditional Chinese medicine composition is suitable for clinical application. The effects of tonifying qi and activating blood, dredging channels and relieving pain, eliminating phlegm and removing blood stasis, tonifying heart and soothing nerves and the like can be achieved.