77 results about "Angor pectoris" patented technology

The invention belongs to the field of biological medicine industry, and discloses a peripheral blood marker and system for identifying the severity of viral myocarditis or coronary artery stenosis. The inventor finds for the first time that the average value of LRG1 in blood is not obviously changed compared with that of a normal person when mild and moderate myocarditis and microcirculation angina pectoris with normal coronary artery or coronary artery stenosis smaller than 10% exist, and the blood LRG1 is obviously increased when the coronary artery stenosis of the coronary heart disease exceeds 70%; when severe myocarditis occurs, the blood LRG1 is also obviously increased, so that the increase of the blood LRG1 is a blood marker for patients with severe myocarditis or severe coronary artery lesion, and the blank that blood indexes are lacked in the prior art to prompt the patients to have severe coronary artery stenosis is filled. By detecting the LRG1 content of the peripheral blood and combining with other conventional examinations, the severity of myocarditis or coronary stenosis can be simply, accurately and quickly distinguished, and a corresponding basis is provided for subsequent accurate treatment.

The invention relates to the field of pharmacy, and provides a crystal form B of a compound cis-(+)-5-[(2-dimethylamino) ethyl]-2-(4-methoxyphenyl)-3-acetoxy-2, 3-dihydro-1, 5-benzothiaza # imgabs0 #-4 (5H)-ketone hydrochloride, which can meet the pharmaceutical requirements of convenient production, processing, transportation, storage and the like. The invention also relates to a preparation method of the crystal form B of the compound, a raw material medicine containing the crystal form B, a composition containing the crystal form B and application of the crystal form B in preparation of medicines for treating angina pectoris, hypertension, coronary heart disease and / or arrhythmia.

The invention belongs to the field of medicinal chemistry, and particularly relates to a cyclovirobuxine D derivative compound shown as a structural formula (I) or a structural formula (Ia), a preparation method and application, experimental results show that the compound shown as the structural formula (I) or the structural formula (Ia) has different degrees of hypoxia and ischemia resistance, so that the compound can be used as a medicine for preventing or treating cardiovascular and cerebrovascular diseases and can be used for preparing medicines for preventing or treating cardiovascular and cerebrovascular diseases. The polypeptide has the potential of treating cardiovascular and cerebrovascular diseases. The cardiovascular and cerebrovascular diseases include but are not limited to angina pectoris, arrhythmia, hypertension, hyperlipidemia and cerebral arterial thrombosis. # imgabs0 #

The invention relates to a crystal form of a compound shown as a formula I or a pharmaceutically acceptable salt thereof and a preparation method of the crystal form of the compound shown as the formula I or the pharmaceutically acceptable salt thereof. The compound of the formula I or the pharmaceutically acceptable salt thereof is used for treating cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary arterial hypertension (WHO levels I, II, III, IV), angina pectoris, thrombus, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hyperplasia, erectile dysfunction, asthma, chronic kidney disease, diabetes, and the like. The composition can be used for treating liver cirrhosis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis or interstitial lung disease.

The invention relates to the field of pharmacy, and provides a crystal form B of a compound cis-(+)-5-[(2-dimethylamino) ethyl]-2-(4-methoxyphenyl)-3-acetoxy-2, 3-dihydro-1, 5-benzothiaza-4 (5H)-one hydrochloride, which can meet the pharmaceutical requirements of convenient production, processing, transportation, storage and the like. The invention also relates to a preparation method of the crystal form B of the compound, a raw material medicine containing the crystal form B, a composition containing the crystal form B and application of the crystal form B in preparation of medicines for treating angina pectoris, hypertension, coronary heart disease and / or arrhythmia.

The present application belongs to the technical field of pharmaceutical preparation, and provides a quick-dissolving nicorandil tablet and a preparation method thereof. The tablet is composed of an active ingredient nicorandil, hydroxypropyl methylcellulose acetate stearate, maltodextrin powder, a disintegrating agent and a lubricant. The product of the present application has good performances in moisture and heat stability and dissolution rate. In particular, the dissolution rate still has the performance of quick dissolution after accelerated investigation, which is beneficial to the emergency treatment of angina pectoris.

A traditional Chinese medicine formula for treating blood vessel clogging belongs to the field of traditional Chinese medicine formulas, and comprises the following main raw materials: 29-31 parts of black pearl, 11-13 parts of codonopsis pilosula, 7-9 parts of saffron crocus, 8-10 parts of angelica sinensis, 190-210 parts of leek, 9-11 parts of pseudo-ginseng, 37-43 parts of hawthorn, 95-105 parts of astragalus membranaceus, 18-22 parts of kudzu vine root, 8-10 parts of peach kernel, 8-10 parts of prepared rehmannia root, 9-11 parts of radix rehmanniae, 11-13 parts of white paeony root, 3 parts of red ginseng, 9-11 parts of radix ophiopogonis, 14-16 parts of spina date seed, 11-13 parts of Chinese yam, 14-15 parts of schisandra chinensis, 9-11 parts of polygonum multiflorum, 7-9 parts of cinnamon, 18-21 , 13-15 parts of anise and 12-14 parts of rhizoma polygonati. The traditional Chinese medicine composition has an obvious improvement effect on coronary artery insufficiency, myocardial ischemia, mitral valve, tricuspid valve, aortic valve regurgitation, chronic heart failure, patients needing operation bypass stenting, angina pectoris, myocardial infarction sequelae, cerebral ischemia, cerebrovascular sequelae and other symptoms caused by cardiac insufficiency, the dosage is small, the effect is fast, the cure rate is high, relapse is not prone to occurring, and the traditional Chinese medicine composition is suitable for clinical application. The effects of tonifying qi and activating blood, dredging channels and relieving pain, eliminating phlegm and removing blood stasis, tonifying heart and soothing nerves and the like can be achieved.

The invention discloses a medicine for treating the heart of a human body, and particularly relates to the field of medicines, the medicine is prepared from the following components in percentage by mass: 13.8% of radix salviae miltiorrhizae, 4.1% of allium macrostemon, 8.3% of semen trichosanthis, 2% of polygala tenuifolia, 8.3% of radix ophiopogonis, 2% of sandalwood, 6.9% of pericarpium citri reticulatae viride, 13.8% of lily, 8.3% of semen boitae, 10.4% of poria cocos, 8.3% of oriental cherry powder and 13.8% of earthworm, and the sum of the mass percentages of the components is 100%. According to the medicine for treating the heart of the human body, traditional Chinese medicine decoction pieces such as salvia miltiorrhiza, allium macrostemon, snakegourd seeds, polygala tenuifolia, radix ophiopogonis, sandalwood, pericarpium citri reticulatae viride, lily, platycladi seeds, poria cocos, oriental cherry powder and lumbricus are crushed and proportioned according to corresponding formula proportions and processes, so that the medicine plays the maximum effects of all the decoction pieces, is easier to take and absorb, and can be taken for a long time after being taken. The traditional Chinese medicine composition has obvious treatment effects on cardiac insufficiency, dyspnea, weakness, fatigue, angina pectoris, palpitation, palpitation and other problems caused by heart problems of heart disease patients, and can effectively treat coronary heart disease, myocardial ischemia, arrhythmia and other heart diseases.

A traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof belong to the field of traditional Chinese medicines. The traditional Chinese medicine composition for treating cardiovascular diseases is prepared from tribulus terrestris, salvia miltiorrhiza, pseudo-ginseng, ligusticum wallichii, astragalus membranaceus, angelica sinensis, immature bitter orange, sandalwood and honey-fried licorice root. The method comprises the following steps: 1, weighing; 2, preparing sandalwood volatile oil; 3, preparing a water extract; and 4, mixing. The traditional Chinese medicine composition has the advantages that (1) multi-target cooperation is realized: the traditional Chinese medicine composition simultaneously acts on three levels of a blood coagulation system, vascular endothelium and myocardial cells, has the functions of activating blood, tonifying qi and regulating qi, and is more comprehensive than a single blood activating formula; (2) treating both symptoms and root causes: improving the symptoms (the effective rate of angina pectoris is 92%) and delaying the pathological progress; (3) high safety: high safety, suitability for long-term administration, no bleeding tendency (APTT is maintained in a normal range) after long-term administration, and wide market prospect; the tribulus terrestris has an antihypertensive effect and is especially suitable for patients with hypertension and coronary heart disease.

The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine composition for treating coronary heart disease and a preparation method and application thereof.The medicine composition is prepared from, by mass, 10-15 parts of radix salviae miltiorrhizae, 10-15 parts of pseudo-ginseng, 10-15 parts of the root of kudzu vine and 4-12 parts of saffron crocus. All the medicine raw materials in the formula play a comprehensive synergistic effect to prevent and treat coronary heart disease angina pectoris and cerebrovascular sclerosis, and the traditional Chinese medicine composition is mild in medicine property and does not cause medicine dependence; meanwhile, aiming at syndromes of blood stasis, collateral obstruction and the like, the medicine composition can achieve a good treatment effect of preventing and treating the coronary heart disease by adopting a treatment method of activating blood and stimulating the menstrual flow, and the medicine composition adopts radix salviae miltiorrhizae for composition, and has a remarkable curative effect through in-vitro and clinical verification. And the traditional compound salvia tablets for promoting blood circulation to remove blood stasis are better than the traditional compound salvia tablets for preventing and treating myocardial ischemia, coronary artery obstruction and vascular restenosis after angioplasty.

The invention relates to a coronary microcirculation disturbance examination technology in non-occlusive coronary diseases, and aims to objectively evaluate the myocardial ischemia degree of angina pectoris patients without occlusive coronary diseases and quantify the myocardial ischemia range caused by microcirculation disturbance through a load dynamic myocardial perfusion imaging (MPI) technology. Siemens third-generation double-source CT is adopted, a coarse pitch scanning mode is utilized, a one-stop CCTA combined MPI technology is achieved, the problem that the radiation dosage is too high is solved, and meanwhile the detection rate of myocardial ischemia is increased. Indexes such as myocardial blood flow (MBF), myocardial blood volume (MBV), time of arrival (TTP), coronary artery blood flow reserve (CFR) and the like of angina pectoris patients and healthy volunteers are compared, and changes of myocardial ischemia areas are objectively evaluated. The degree and range of microcirculation disturbance are quantitatively evaluated, and an infarction region and an ischemic region are identified. Quantitative evaluation is carried out on coronary artery microcirculation of the angina pectoris patient in clinical work, and a basis is provided for early intervention.

The invention discloses a curative effect evaluation system and method for traditional Chinese medicine intervention of angina pectoris, and belongs to the technical field of medical services, and the system comprises a case collection module which collects information of hospitalized patients with intermingled phlegm and blood stasis syndromes which are clinically diagnosed as UA, and carries out the filing of the information of each patient; the medication mode queue module is used for queuing the filing information of each patient; by adopting a two-way queue research design and depending on a'chest stuffiness and pains special disease library ', grouping is carried out according to a plurality of optimized traditional Chinese medicine medication modes as exposure factors, different medication mode queues are established, retrospective data acquisition and prospective follow-up visit are carried out on all subjects, curative effect evaluation modeling of grouped crowds is carried out, and the curative effect of the subjects is evaluated. The correlation between data generated by different treatment times is fully considered, an evaluation model capable of dynamically evaluating the curative effect of the patient is established, real-time, dynamic and accurate evaluation of the clinical curative effect of the traditional Chinese medicine is realized, and a real-world traditional Chinese medicine evidence-based basis is provided for guiding clinical practice and making health policies.

The present application belongs to the technical field of medicine, and relates to derivatives of carboxylic acid groups introduced by 10-position hydroxyl in the structure of ginkgolide B and ester derivatives of the carboxylic acid groups, and pharmaceutically acceptable organic or inorganic salts, as shown in formula 1 and formula 2. The present application takes ginkgolide B as a matrix, and is chemically modified to improve the solubility, increase the bioavailability, and enhance the curative effect of ginkgolide B. The prepared compound and carboxylic acid salt thereof have significant platelet activating factor antagonism, anticoagulation effect, and acute cerebral ischemia effect, and can be used for preparing medicines for preventing and treating ischemic stroke, thrombosis, angina pectoris, cardiopulmonary infarction, and diseases related to platelet activating factor, such as inflammation, asthma, and the like.

The present application belongs to the technical field of sports rehabilitation, and aims at the technical problem that the current expert consensus is mainly to guide the patients after interventional therapy to carry out cardiac rehabilitation, and the population is not defined on the patients with angina after PCI, so the guidance of sports rehabilitation treatment is not accurate, and there is currently a lack of cardiac rehabilitation guidance technology for such patients. The present application adopts one-stop load myocardial perfusion technology, and combines cardiopulmonary exercise test to evaluate the cardiopulmonary function of the patient and formulate the exercise intensity. On the basis of the cardiopulmonary exercise test data and the clinical data of the patient, the transmural index of myocardial perfusion, a semi-quantitative index, is used to grade the microcirculation disorder, and the exercise intensity scheme of the patient is adjusted on this basis. After the evaluation of the present application by myocardial perfusion, the patient is given higher intensity training, and the degree of increase of VO2 is significantly improved compared with the traditional rehabilitation scheme.

The present invention provides a compound having a PDHK inhibitory activity and useful for the treatment or prophylaxis of diabetes (type 1 diabetes, type 2 diabetes etc.), insulin resistance syndrome, metabolic syndrome, hyperglycemia, hyperlactacidemia, diabetic complications (diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, cataract etc.), cardiac failure (acute cardiac failure, chronic cardiac failure), cardiomyopathy, myocardial ischemia, myocardial infarction, angina pectoris, dyslipidemia, atherosclerosis, peripheral arterial disease, intermittent claudication, chronic obstructive pulmonary disease, brain ischemia, cerebral apoplexy, mitochondrial disease, mitochondrial encephalomyopathy, cancer, pulmonary hypertension or Alzheimer disease. The present invention relates to a compound of the formula [I-a] or the formula [II], or a pharmaceutically acceptable salt thereof:wherein each symbol means the same as that described in the specification.

The invention belongs to the technical field of medicine application, and relates to application of a composition in preparation of a medicine for treating unstable angina pectoris, the composition and combined use of the composition and nicodil are used for improving the attack frequency of the unstable angina pectoris and the lasting time of the unstable angina pectoris, reducing the levels of LDL-C, TC and TG in serum, and improving the treatment effect of the unstable angina pectoris. According to the present invention, the application of the preparation of the unstable angina pectoris treatment drug can be provided, such that the HDL-C level in the serum can be increased, the BNP level and the LVEDD level in the plasma can be reduced, and the LVEF level can be increased; the composition disclosed by the invention and the combination of the composition and nicodil can improve the attack frequency of unstable angina pectoris, shorten the symptom duration and improve the effective rate of treatment.

The present invention relates to the field of biomarker technology, and in particular to the LL‑37‑ApoB‑100 biomarker and its application. The present invention has discovered a biomarker LL‑37‑ApoB‑100 complex in blood and / or atheromatous plaques related to the prediction and diagnosis of coronary atherosclerosis / coronary heart disease. Antibodies are prepared using the marker, and coronary atherosclerosis or coronary atherosclerosis-related diseases can be predicted and diagnosed by enzyme-linked immunosorbent assay, and different subtypes of coronary heart disease such as coronary atherosclerosis and stable angina, unstable angina and acute myocardial infarction can be effectively identified. Compared with traditional coronary atherosclerosis or coronary heart disease markers, the biomarker has significant advantages such as higher sensitivity, higher specificity, faster and simpler detection, lower cost and less trauma.

The invention discloses a kidney-tonifying and spleen-tonifying traditional Chinese medicine composition as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10 to 40 parts of roasted turtle shell, 10 to 30 parts of herba taxilli, 10 to 20 parts of cortex eucommiae, 10 to 30 parts of semen cuscutae, 10 to 30 parts of herba cistanche, 10 to 30 parts of radix codonopsis, 10 to 30 parts of poria cocos, 10 to 30 parts of rhizoma polygoni cuspidati and 10 to 30 parts of rhizoma chuanxiong. The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying kidney and spleen, dissipating blood stasis and relieving pain, and softening hardness to dissipate stagnation, is a proved recipe for clinical application for many years, is stable in curative effect, few in adverse reaction and good in healing, and provides an effective traditional Chinese medicine preparation for treating stable angina pectoris. During preparation of the traditional Chinese medicine composition, monarch drugs are pulverized and used as medicines, other medicines are extracted and concentrated, medicinal components are fully reserved, and the traditional Chinese medicine composition is simple in process, high in universality and suitable for large-scale production.

The present invention discloses a portable drug storage device for angina pectoris, specifically relating to the technical field related to drug storage devices, comprising a base, the lower portion of the base being provided with a restraining strap for tying the device to a patient's arm, the upper end of the base being provided with a storage mechanism, the storage mechanism comprising four storage boxes, the inner middle side of the storage box being provided with a baffle, the baffle separating the storage box into a rectangular frame located on the left side of the storage box and an arc-shaped frame located on the right side of the storage box. The portable drug storage device for angina pectoris described in the present invention, by configuring the storage mechanism to be composed of a plurality of storage boxes, allows each pill to be stored separately, thereby preventing some pills from frequently coming into contact with the outside world, thereby extending the storage time of the medicine. In addition, by providing structures such as a V-shaped control panel, a cover plate, and a support plate, the patient can operate the device with one hand, thereby preventing the patient from being unable to take medicine in time when the disease occurs, causing the patient to suffer greater pain.

The invention discloses angina pectoris relieving auxiliary equipment for elderly patients in the technical field of medical instruments, and the angina pectoris relieving auxiliary equipment comprises a shell and a lifting mechanism, the lifting mechanism is arranged on one side of the shell and fixedly connected with the shell, a longitudinal adjusting mechanism is arranged on one side of the lifting mechanism, and a transverse adjusting mechanism is arranged at the bottom of the longitudinal adjusting mechanism; a fixing column is arranged at the bottom of the transverse adjusting mechanism, a socket is arranged at the bottom of the fixing column, an inserting block is arranged in the socket, the inserting block and the socket are fixed in a penetrating mode, a clamping ring is arranged on one side of the inserting block, a massage pen is arranged in the clamping ring, the model of the massage pen is FK-DZZJB, a heating wire is arranged in the shell, and the heating wire is fixedly connected with the shell. By means of the lifting mechanism, the longitudinal adjusting mechanism, the transverse adjusting mechanism, the fixing column, the inserting base, the inserting block, the clamping ring and the massage pen, the automatic massage function of the student position of a patient is achieved, manual massage of medical workers is not needed, time and labor are saved, and the hands of the patient can be heated.

The invention provides a prediction tool for auxiliary diagnosis of coronary heart disease through combination of traditional Chinese medicine and western medicine and a score table, particularly relates to a coronary heart disease noninvasive auxiliary diagnosis score table based on four diagnosis information of traditional Chinese medicine, and belongs to the technical field of medical diagnosis. The method focuses on a non-invasive prediction model of the coronary heart disease for the first time, and solves the problems of strong invasiveness and unintegration of traditional Chinese medicine characteristics in the prior art. Core predictive variables are screened by collecting four diagnosis information (including intraocular angular blood vessel thickening, blood stasis expression and other traditional Chinese medicine sign characteristic clinical expressions) of coronary heart disease patients, and a Logistic regression model is constructed and converted into a score table. The scale comprises indexes such as age, combined diseases, typical angina pectoris, abnormal angular blood collaterals in eyes, blood stasis and kidney deficiency, and the coronary heart disease is diagnosed when the total score is greater than or equal to 4. According to the method, the model for predicting the coronary heart disease is constructed by utilizing a statistical method, and the model is converted into the score table which is easy to operate through the statistical method, so that clinical popularization and application are facilitated, doctors are assisted to make accurate and efficient clinical decisions, and clinical doctors are guided to make accurate and effective treatment schemes.

The application discloses a kind of intelligent diagnosis and decision support method of coronary heart disease angina TCM syndrome factor based on HIS, it is related to medical information and TCM diagnosis and treatment technical field, the method will coronary heart disease angina TCM syndrome factor diagnostic criteria be deconstructed into standardization diagnostic item, build machine-readable weight rule base containing score, threshold and severity grading rule, response syndrome differentiation operation generates electronic collection form, receives structured data storage to the TCM syndrome factor fact table associated with patient main index and medical record, after structured data is submitted, trigger intelligent computing engine verification essential item, total score is accumulated, determine the establishment of syndrome factor and severity, through TCM diagnosis and treatment knowledge graph push personalized treatment or nursing suggestion in clinical business node, and continuously update rule base and knowledge graph through clinical data feedback.The application integrates corresponding function module to realize and deeply fuse with hospital information system, improves the standardization and efficiency of diagnosis and treatment, and has strong practicality.

The invention belongs to the technical field of exercise rehabilitation, and aims to solve the problems that at present, expert consensus is mainly used for guiding patients after interventional therapy to perform heart rehabilitation, people are not defined on patients suffering from angina pectoris after PCI (Peripheral Component Interconnect), so that the guidance of the patients on exercise rehabilitation is inaccurate, and the rehabilitation effect is poor. In order to solve the technical problems in the prior art that heart rehabilitation guidance for the patients is lacked at present, a one-stop load myocardial perfusion technology is adopted, cardiopulmonary function evaluation is performed on the patients and exercise intensity is formulated in combination with cardiopulmonary exercise tests, and on the basis of cardiopulmonary exercise test data and clinical data of the patients, the cardiopulmonary exercise intensity is formulated. The microcirculation disturbance is graded by adopting a semi-quantitative index, namely a myocardial perfusion transmural index, and the exercise intensity scheme of a patient is adjusted on this basis. After myocardial perfusion is adopted for evaluation, higher-intensity training is provided for a patient, and the VO2 rising degree is remarkably improved compared with a traditional rehabilitation scheme.

The purpose of the present disclosure is to provide a coated stent for coronary arteries, which enables effective treatment of coronary artery perforations that may occur during procedures such as those for angina pectoris and myocardial infarction. The coated stent for coronary arteries according to the present disclosure can prevent restenosis after implantation and provides enhanced in vivo stability due to reduced detachment force.

The invention discloses an exercise rehabilitation system and method for a PCI postoperative angina pectoris patient, and relates to the technical field of exercise rehabilitation, and the system comprises a perfusion scanning module which is used for carrying out cardiac coronary artery imaging and myocardial perfusion scanning on the patient, and obtaining a myocardial perfusion index of the patient; the danger layering module is used for carrying out danger layering on patients according to myocardial perfusion indexes; the scheme making module is used for making an exercise rehabilitation scheme according to the danger layering result; the data feedback module is used for monitoring the exercise intensity and the heart rate of the patient in the exercise rehabilitation process and adjusting the exercise rehabilitation scheme according to the monitored data. According to the technical scheme, the reason of angina pectoris attack of the patient can be determined, theoretical guidance is provided for further exercise rehabilitation, and the method has high application value.

The invention discloses a Chinese medicine composition containing aconite for treating unstable angina pectoris, wherein the raw materials thereof are aconite, ginseng, American ginseng, pseudostellaria, yam, cassia twig, ophiopogon, schisandra, cornus officinalis, asparagus cochinchinensis, radix rehmanniae, spiny date seeds, keel, and oyster. The results of clinical efficacy observation tests confirm that the Chinese medicine composition of the invention can significantly improve the clinical symptoms of patients with unstable angina pectoris, significantly reduce the duration and frequency of their angina attacks, improve their cardiac function, resist myocardial oxidation, reduce stress response, antagonize ET‑1, and promote the recovery of vascular endothelial function.

The present invention relates to the technical field of medicine, and to derivatives represented by formula 1 and formula 2 in which a carboxylic acid group is introduced into the structure of Ginkgolide B by means of a hydroxyl group at the 10-position and ester derivatives of carboxylic acid groups, and pharmaceutically acceptable organic or inorganic salts. Ginkgolide B is used as a parent body and is prepared by means of chemical structure modification so as to achieve the goals of improving solubility, increasing bioavailability and enhancing healing efficacy. The prepared compound and carboxylate salts thereof have significant platelet activating factor antagonism, an anticoagulant effect and an anti-acute cerebral ischemia effect, and can be used for preparing a drug for preventing and treating ischemic stroke, thrombosis, angina pectoris, cardiopulmonary infarction, as well as inflammation, asthma and other diseases related to a platelet activating factor.

The application discloses an angina pectoris relieving treatment device for old cardiovascular internal medicine, and relates to the technical field of medical care, which comprises a thimble, a chassis, a pressing column, a first spring and a pressing frame, the chassis is rotationally connected with symmetrically arranged thimbles, the two thimbles are fixed through a snap pin, the chassis is slidably connected with the pressing column, the pressing column is provided with the pressing frame, and the first spring is connected between the pressing column and the chassis. The two thimbles can be worn on the wrists of patients with light symptoms, the pressing column is pressed, the pressing column and the pressing frame massage the neiguan acupoint of the patient to relieve pain, and the pressing column and the pressing frame can also be attached to the chest of patients with severe symptoms to massage the chest of the patient and relieve pain.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a healthy energy supporting, yang warming and meridian dredging paste which is technically characterized by being prepared from honey-fried ephedra, wine-processed cornus, safflower, red paeony root, stevia rebaudiana, prepared common monkshood daughter root, Chinese yam, kudzuvine root, prepared rhizome of rehmannia, platycodon grandiflorum, pollen typhae, ligusticum wallichii, angelica sinensis, radix achyranthis bidentatae, astragalus membranaceus, asarum, radix bupleuri, liquorice, peach kernel, lignum dalbergiae odoriferae and fructus aurantii according to a specific weight part ratio. According to the ointment formula, the theory of Zheng method of Yandezhi teaching professor and the experience of Radix Astragali-Radix Puerariae formula of Guizhongguang national medicine master are fused, a treatment system which warms yang, benefits qi, promotes blood circulation, removes blood stasis, strengthens the body resistance and dredges collaterals is established, and the ointment formula accurately aims at the core pathogenesis of yang deficiency and blood stasis type coronary heart disease angina pectoris and chronic heart failure. Clinical tests prove that the ointment is remarkably superior to conventional treatment (Plt; 0.05) in the aspects of improving traditional Chinese medicine syndromes and improving heart functions, and is good in safety; moreover, the preparation is an oral ointment, is moist and sweet in quality, is convenient to take for a long time, and has remarkable clinical application value and popularization prospect.

The present invention relates to a novel extended release composition of trimetazidine or salt thereof in the form of pellet which are prepared by matrix technology in the treatment of angina pectoris. The pellet according to present invention are prepared by matrix technology comprising one or more extended release polymers along with one or more pharmaceutically acceptable excipients.