20 results about "Angor pectoris" patented technology

The invention relates to a crystal form of a compound shown as a formula I or a pharmaceutically acceptable salt thereof and a preparation method of the crystal form of the compound shown as the formula I or the pharmaceutically acceptable salt thereof. The compound of the formula I or the pharmaceutically acceptable salt thereof is used for treating cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary arterial hypertension (WHO levels I, II, III, IV), angina pectoris, thrombus, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hyperplasia, erectile dysfunction, asthma, chronic kidney disease, diabetes, and the like. The composition can be used for treating liver cirrhosis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis or interstitial lung disease.

The present application belongs to the technical field of medicine, and relates to derivatives of carboxylic acid groups introduced by 10-position hydroxyl in the structure of ginkgolide B and ester derivatives of the carboxylic acid groups, and pharmaceutically acceptable organic or inorganic salts, as shown in formula 1 and formula 2. The present application takes ginkgolide B as a matrix, and is chemically modified to improve the solubility, increase the bioavailability, and enhance the curative effect of ginkgolide B. The prepared compound and carboxylic acid salt thereof have significant platelet activating factor antagonism, anticoagulation effect, and acute cerebral ischemia effect, and can be used for preparing medicines for preventing and treating ischemic stroke, thrombosis, angina pectoris, cardiopulmonary infarction, and diseases related to platelet activating factor, such as inflammation, asthma, and the like.

The present invention provides a compound having a PDHK inhibitory activity and useful for the treatment or prophylaxis of diabetes (type 1 diabetes, type 2 diabetes etc.), insulin resistance syndrome, metabolic syndrome, hyperglycemia, hyperlactacidemia, diabetic complications (diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, cataract etc.), cardiac failure (acute cardiac failure, chronic cardiac failure), cardiomyopathy, myocardial ischemia, myocardial infarction, angina pectoris, dyslipidemia, atherosclerosis, peripheral arterial disease, intermittent claudication, chronic obstructive pulmonary disease, brain ischemia, cerebral apoplexy, mitochondrial disease, mitochondrial encephalomyopathy, cancer, pulmonary hypertension or Alzheimer disease. The present invention relates to a compound of the formula [I-a] or the formula [II], or a pharmaceutically acceptable salt thereof:wherein each symbol means the same as that described in the specification.

The application discloses a kind of intelligent diagnosis and decision support method of coronary heart disease angina TCM syndrome factor based on HIS, it is related to medical information and TCM diagnosis and treatment technical field, the method will coronary heart disease angina TCM syndrome factor diagnostic criteria be deconstructed into standardization diagnostic item, build machine-readable weight rule base containing score, threshold and severity grading rule, response syndrome differentiation operation generates electronic collection form, receives structured data storage to the TCM syndrome factor fact table associated with patient main index and medical record, after structured data is submitted, trigger intelligent computing engine verification essential item, total score is accumulated, determine the establishment of syndrome factor and severity, through TCM diagnosis and treatment knowledge graph push personalized treatment or nursing suggestion in clinical business node, and continuously update rule base and knowledge graph through clinical data feedback.The application integrates corresponding function module to realize and deeply fuse with hospital information system, improves the standardization and efficiency of diagnosis and treatment, and has strong practicality.

The application discloses an angina pectoris relieving treatment device for old cardiovascular internal medicine, and relates to the technical field of medical care, which comprises a thimble, a chassis, a pressing column, a first spring and a pressing frame, the chassis is rotationally connected with symmetrically arranged thimbles, the two thimbles are fixed through a snap pin, the chassis is slidably connected with the pressing column, the pressing column is provided with the pressing frame, and the first spring is connected between the pressing column and the chassis. The two thimbles can be worn on the wrists of patients with light symptoms, the pressing column is pressed, the pressing column and the pressing frame massage the neiguan acupoint of the patient to relieve pain, and the pressing column and the pressing frame can also be attached to the chest of patients with severe symptoms to massage the chest of the patient and relieve pain.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a healthy energy supporting, yang warming and meridian dredging paste which is technically characterized by being prepared from honey-fried ephedra, wine-processed cornus, safflower, red paeony root, stevia rebaudiana, prepared common monkshood daughter root, Chinese yam, kudzuvine root, prepared rhizome of rehmannia, platycodon grandiflorum, pollen typhae, ligusticum wallichii, angelica sinensis, radix achyranthis bidentatae, astragalus membranaceus, asarum, radix bupleuri, liquorice, peach kernel, lignum dalbergiae odoriferae and fructus aurantii according to a specific weight part ratio. According to the ointment formula, the theory of Zheng method of Yandezhi teaching professor and the experience of Radix Astragali-Radix Puerariae formula of Guizhongguang national medicine master are fused, a treatment system which warms yang, benefits qi, promotes blood circulation, removes blood stasis, strengthens the body resistance and dredges collaterals is established, and the ointment formula accurately aims at the core pathogenesis of yang deficiency and blood stasis type coronary heart disease angina pectoris and chronic heart failure. Clinical tests prove that the ointment is remarkably superior to conventional treatment (Plt; 0.05) in the aspects of improving traditional Chinese medicine syndromes and improving heart functions, and is good in safety; moreover, the preparation is an oral ointment, is moist and sweet in quality, is convenient to take for a long time, and has remarkable clinical application value and popularization prospect.

The application belongs to the field of pharmaceutical chemistry, and particularly relates to a cyclovirobuxin D derivative structural formula (I) or formula (Ia) compound, a preparation method and application. Experimental results show that the structural formula (I) or formula (Ia) compound has different degrees of hypoxia tolerance and ischemia capacity, and therefore the above-mentioned compound can be used as a drug for preventing or treating cardiovascular and cerebrovascular diseases, and has potential for treating cardiovascular and cerebrovascular diseases. The cardiovascular and cerebrovascular diseases include but are not limited to angina pectoris, arrhythmia, hypertension, hyperlipidemia and ischemic stroke.

The application belongs to the technical field of medicine, and particularly relates to application of acacetin or 6-hydroxyflavone in preparation of anti-angina pectoris drugs, and aims to solve the problems of adverse reactions such as blood pressure drop, reflex tachycardia and the like caused by non-selective vasodilation of existing anti-angina pectoris drugs, wherein the drug improves myocardial blood supply by selectively dilating coronary vessels of the heart, wherein acacetin dilates coronary vessels of the heart by inhibiting cardiac coronary vessel myosin light chain kinase and activating myosin light chain phosphatase, and 6-hydroxyflavone dilates coronary vessels of the heart by inhibiting protein kinase C and enhancing myosin light chain phosphatase activity; and the acacetin or 6-hydroxyflavone significantly reduces the symptoms of myocardial ischemia of rats caused by isopropyl adrenaline, improves characteristic ECG abnormal changes of angina pectoris, does not affect heart rate and systemic blood pressure, and is safer, thereby providing a potential drug selection for anti-angina pectoris treatment.

The invention relates to the field of cardiovascular disease treatment, in particular to a traditional Chinese medicine composition for improving heart health and a preparation method thereof. The traditional Chinese medicine composition is characterized by comprising twenty traditional Chinese medicines including 5 to 20g of radix salviae miltiorrhizae, 5 to 15g of flos carthami, 5 to 15g of radix paeoniae rubra, 5 to 15g of frankincense, 5 to 15g of myrrh, 5 to 15g of radix notoginseng, 3 to 10g of clove, 5 to 15g of radix aucklandiae, 3 to 10g of agilawood, 5 to 15g of sandalwood, 3 to 10g of storax, 5 to 15g of rhizoma corydalis, 5 to 15g of ligusticum wallichii, 3 to 15g of schisandra chinensis, 3 to 15g of borneol, 500ml of olive oil and the like, and any one or any combination of 5 to 15g of radix codonopsis, 5 to 15g of radix ophiopogonis and 5 to 15g of lignum dalbergiae odoriferae is contained in the formula. The medicine can be quickly absorbed by smelling the medicine, directly enters blood, and is suitable for relieving acute angina pectoris, chest distress and shortness of breath. The health-care tea is an ideal heart health improving product, and is especially suitable for people with coronary heart disease history or high risk of cardiovascular diseases.

The present application relates to a kind of traditional Chinese medicine composition for treating coronary atherosclerotic disease stable angina, the traditional Chinese medicine composition is made of the following weight parts of raw medicinal materials: Radix Bupleuri 10-14 parts, Ramulus Cinnamomi 3-7 parts, Herba Agrimoniae 13-17 parts, Salvia Miltiorrhiza 13-17 parts, Radix Paeoniae Alba 3-7 parts, Rhizoma Pinelliae Praeparatum 4-8 parts, Radix Scophularae 3-7 parts, Radix Ginseng 3-7 parts, Radix Glycyrrhizae 1-5 parts, Zingiber officinale 3-7 parts, Fructus Jujubae 4-8 parts.The present application also provides the application of traditional Chinese medicine composition in the preparation of medicine for treating coronary atherosclerotic disease stable angina.The treatment principle of the present application is: regulating liver and unblocking yang, regulating qi and activating blood.The drugs in the present application are used together, and the effect is enhanced, can regulate Ying and Wei, regulate liver qi, unblock chest yang, and unblock blood vessels, so as to achieve the effect of preventing and treating stable angina pectoris of coronary heart disease.The present application can effectively improve the angina pectoris symptoms of patients with stable angina pectoris of coronary heart disease, improve the quality of life of patients, has certain clinical value, and is worth further research and promotion.

The invention discloses an intelligent auxiliary diagnosis system and method for unstable angina pectoris based on a biomarker RETN, and belongs to the technical field of biological medicine. According to the present invention, the Olink high-throughput proteomics technology screening finds that the expression of RETN and other proteins in the UA patient serum is up-regulated, and after the ELISA verification, the RETN and other proteins are combined with the clinical conventional indexes, and the machine learning algorithm is adopted to construct the multi-dimensional diagnosis system; the prediction module adopts a double-layer architecture, a base module layer parallelly runs six algorithms to capture a nonlinear relationship, a meta module layer adopts logistic regression secondary modeling, and the generalization ability is improved. The system and the method can realize accurate recognition and dynamic monitoring of UA early lesion, break through the bottleneck of traditional detection, make up for the defect of insufficient specificity, and overcome the limitation of incapability of repeated monitoring. The AUC of the diagnosis model in an independent verification queue reaches 0.842 or above, the accuracy rate exceeds 76%, UA patients can be screened, the coronary artery stenosis degree can be evaluated, and personalized treatment can be assisted.

The present application relates to the field of pharmacy, and provides a crystal form B of a compound cis-(+)-5-[(2-dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-acetyloxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride, which can meet the pharmaceutical requirements such as production, processing, transportation and storage convenience. The present application also relates to a preparation method of the crystal form B of the compound, a bulk drug and a composition containing the same, and a use of the crystal form B in preparation of drugs for treating angina, hypertension, coronary heart disease and / or arrhythmia.

The present application provides a kind of traditional Chinese medicine composition and its preparation method and application, belong to medical field.The traditional Chinese medicine composition of the present application includes the following weight parts of raw materials: 15-30 parts of Huangqi, 15-30 parts of Maidong, 6-9 parts of Wuweizi, 9-12 parts of Jiangxiang, 12-15 parts of Yincheng.The traditional Chinese medicine composition of the present application is simple in force, can benefit heart qi, nourish heart yin to support healthy, can also resolve blood stasis, unblock heart vessel to drive evil, supplement and pass through to be used to supplement as main, so that qi yin is supplemented, blood stasis is removed, and the effect of benefiting qi and nourishing yin, promoting blood circulation to remove blood stasis is achieved together.It has significant clinical effect on chronic stable exertional angina pectoris with qi yin deficiency and heart vessel stasis.

The application provides a live heart pill liposome aerosol and a preparation method and application thereof, the live heart pill liposome aerosol comprising drug-loaded liposomes, a propellant and a cosolvent; the drug-loaded liposomes comprise core materials and wall materials; the mass ratio of the core materials to the wall materials is 1:(5-11); the core materials comprise traditional Chinese medicine active ingredients; the wall materials comprise neutral lipids, anionic lipids and sterols; the traditional Chinese medicine active ingredients comprise 400-600 parts of ginseng, 150-300 parts of ox gall, 50-150 parts of ganoderma lucidum, 15-50 parts of pearls, 2-10 parts of aconite, 20-100 parts of safflower, 2-20 parts of musk, 5-15 parts of bear gall, 4-20 parts of toad venom and 2-10 parts of borneol in terms of weight parts. The live heart pill liposome aerosol of the application is administered through pulmonary inhalation, has a quick effect after administration and is obviously superior to an oral dosage form, and can better meet the timeliness requirement of first-aid medicines in the acute attack of angina pectoris.

This application discloses a method, apparatus, device, and storage medium for pushing cardiac rehabilitation prescriptions to patients with stable angina pectoris. The method includes: acquiring original patient medical data from at least one external subsystem via an asynchronous parallel interface; determining snapshot information of the patient's status under various predefined cardiac rehabilitation rules based on the original patient medical data; correcting at least one of the exercise prescription parameters, medication prescription parameters, nutritional prescription parameters, psychological prescription parameters, and smoking cessation prescription parameters in the corresponding rehabilitation prescription based on the snapshot information of the patient's status, thereby determining rehabilitation prescription information; predicting the correction scheme and resource scheduling scheme for rehabilitation activities against preset long-term goals in the corresponding event nodes based on the original patient data and rehabilitation prescription information, thereby determining correction prescription information and resource scheduling prescription information; and pushing the rehabilitation prescription information, correction prescription information, and resource scheduling prescription information to multiple terminals for visual display.

This invention discloses the use of tanshinone or its pharmaceutically acceptable salts or derivatives in the preparation of PDK4 agonists. Tanshinone reverses EndMT and inhibits the progression of coronary artery disease atherosclerosis and endothelial dysfunction by restoring the metabolic regulator PDK4. It effectively prevents the progression of coronary artery disease by targeting anti-EndMT and metabolic regulation to improve abnormal endothelial function. The use of tanshinone in the preparation of drugs for treating angina pectoris in coronary artery disease opens up new application areas for tanshinone.

The present application relates to the field of pharmacy, and provides a crystal form B of a compound cis-(+)-5-[(2-dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-acetyloxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride, which can meet the pharmaceutical requirements such as production, processing, transportation and storage convenience. The present application also relates to a preparation method of the crystal form B of the compound, a bulk drug and a composition containing the same, and a use of the crystal form B in preparation of drugs for treating angina, hypertension, coronary heart disease and / or arrhythmia.

The present application relates to the field of pharmacy, and provides a crystal form B of a compound cis-(+)-5-[(2-dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-acetyloxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride, which can meet the pharmaceutical requirements such as production, processing, transportation and storage convenience. The present application also relates to a preparation method of the crystal form B of the compound, a bulk drug and a composition containing the same, and a use of the crystal form B in preparation of drugs for treating angina, hypertension, coronary heart disease and / or arrhythmia.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating thoracic obstruction phlegm-qi stagnation type cardiovascular diseases and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from fructus trichosanthis, rhizoma pinelliae preparata, arisaema cum bile, fructus aurantii, cortex magnoliae officinalis, pericarpium citri reticulatae, poria cocos and honey-fried licorice root. The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying qi and relieving chest stuffiness and arthralgia, is mainly used for treating chest stuffiness and pains and phlegm-qi stagnation type cardiovascular diseases, and is particularly suitable for patients suffering from coronary heart disease and angina pectoris. Besides, on the basis of a traditional medical formula, a modern preparation process is utilized and deeply optimized, and a dynamic decoction process and a one-step granulation technology are adopted, so that the preparation method has the advantages of simple and convenient preparation process, high efficiency, energy conservation, less damage to effective components and the like.

The invention relates to the technical field of medicines related to migraine, in particular to application of a Qiandang pulse-activating composition in preparation of medicines for treating migraine. The astragalus membranaceus-salvia miltiorrhiza pulse-activating composition is prepared from the following raw materials: astragalus membranaceus, salvia miltiorrhiza, angelica sinensis, safflower carthamus and cassia twig. The composition not only has the efficacy of treating stable labor coronary heart disease angina pectoris, but also can be used for treating migraine. According to the technical scheme, the technical problem that traditional Chinese medicines capable of effectively treating migraine are lacked in the prior art can be solved. Although the migraine can be effectively relieved in a short time through western medicine treatment, the migraine cannot be treated from the source, and on the contrary, some serious adverse reactions can be caused. The application potential of the composition in the new indication is disclosed by deeply researching and expanding the application of the composition, a new medicine choice is provided for traditional Chinese medicine treatment of migraine, and the blank of traditional Chinese medicine treatment in the field is favorably made up.