433 results about "Angor pectoris" patented technology

Compounds of the formula

wherein R₁, R₂, R₃, R₄, X and Y are as defined, which have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis, and the like; allergic diseases such as asthma, or disorders of male or female genital function and the like.

The invention discloses a preparation method of Radix Puerariae wine. The preparation method comprises the following steps: collecting fresh Radix Puerariae, cleaning, cutting into pieces, adding water, and performing homogenate to obtain a Radix Puerariae homogenate liquid; sterilizing the Radix Puerariae homogenate liquid at 70-110 DEG C for 5-120 minutes, cooling to 50-65 DEG C, and regulatingthe pH value to 5-7 to obtain a sterilized solution; adding amylase into the sterilized solution until the mass percentage of the amylase is 0.01-5, performing enzymolysis at 50-90 DEG C for 0.5-24 hours, adding glucoamylase until the mass percentage of the glucoamylase is 0.01-5, and performing enzymolysis at 50-70 DEG C for 4-12 hours; then increasing the temperature to 70-110 DEG C, holding the temperature for 20-150 minutes, and cooling to 20-60 DEG C to obtain an enzymolysis solution; and finally adding saccharomyces cerevisiae into the enzymolysis solution until the mass percentage of the saccharomyces cerevisiae is 0.01-0.05, fermenting at 24-40 DEG C for 5-10 days, and filtering to obtain the Radix Puerariae wine. The preparation method is simple; and the prepared Radix Puerariae wine is high in Puerarin content and has an alcohol degree of 15-35, and can be applied to adjuvant therapy for diseases such as hypertension, angina pectoris, coronary heart disease, hyperlipidemia and the like.

The invention relates to a fructus crataegi flaked candy and a preparation method of the fructus crataegi flaked candy. The flaked candy comprises, by weight, 1-40 pars of fructus crataegi powder, 5-30 parts of microcrystalline cellulose, 5-60 parts of sorbit, 5-30 parts of maltodextrin, 0.1-4 parts of lubricants and appropriate adhesion agents. Smashing, 80-mesh screening and even mixing are performed on the fructus crataegi powder and all the auxiliary materials, and then damp mass preparing, granulation, drying, granule arranging and flaking are performed to obtain the fructus crataegi candy. The fructus crataegi flaked candy has the functions of strengthening the spleen and stomach and aiding digestion, and has a certain therapeutic effect on high blood pressure, coronary disease, angor pectoris, hyperlipemia, stomachache, diarrhea and other diseases.

An ethylester of fatty acid containing high-content and-purity DHA and high-purity EPA, especially EPA-E and DHA-E in weight ratio of 1: (1.01-38), a medicine prepared from it for preventing and treating hyperlipemia, angina pectoris and cerebral infarction, and its preparing process are disclosed.

It relates to an endogenous repair factor production accelerator which comprises one or at least two selected from prostaglandin (PG) I2 agonist, EP2 agonist and EP4 agonist. Since prostaglandin (PG) I2 agonist, EP2 agonist or EP4 agonist has various endogenous repair factor production accelerating action, angiogenesis acceleration action and stem cell differentiation induction action, it is useful as preventive and/or therapeutic agents for ischemic organ diseases (e.g., arteriosclerosis obliterans, Buerger disease, Raynaud disease, myocardial infarction, angina pectoris, diabetic neuropathy, spinal canal stenosis, cerebrovascular accidents, cerebral infarction, pulmonary hypertension, bone fracture, Alzheimer disease, etc.) and various cell and organ diseases.

The invention discloses an application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy, which can be used for treating vascular nerve cephalalgia, cerebral thrombus, cerebrovascular angiosclerosis, coronary heart diseases, angina pectoris, hypertension, or asomnia, or common cold, or women's dysmenorrheal.

The invention discloses a PEGylated scutellarin compound and a preparation method thereof. The PEGylated scutellarin compound is as the shown formula (IV) and the PEGylated scutellarin compound can be applied to preparing medicaments applied to treating cerebral thrombosis, cerebral infarction, cerebral apoplexy, sequelaes caused by cerebral apoplexy, coronary heart disease or angina. Compared with the original scutellarin compound, the water solubility of the scutellarin compound is increased obviously; simultaneously, pharmacodynamics experiment on the mice model of cerebral ischemia-reperfusion shows that: compared with the original medicament, the biological activity of the scutellarin promedicament is strengthened obviously.

The invention relates to the preparation field of alcoholic beverage, in particular to gingko wine preparation with high health care component content, which is produced by taking deserted ginkgo biloba sarcotesta as the raw material, and adopting biological enzyme degrading pectic substance, cellulose, amylum, and other substances, and adopting the processes of wine yeast and natural grape fermentation or off-flavor alcohol infusing after enzyme destruction and defecation. The problems of foreign flavor and toxic component are simultaneously solved. The health care function of the gingko wine is more powerful than that of grape wine, the wine body is unique, the fruit aroma is stronger, the gingko wine is golden-colored and full of nutriments, with pure taste; and the gingko wine has the effects of dilating coronary arteries, enhancing blood flow, inhibiting blood coagulation, activating plasmin system, improving cardiotrophin, promoting cholesterin conversion, maintaining blood vessel elasticity, preventing and treating thromboembolia, coronary heart disease, angina pectoris, cerebral vasospasm and preventing cancer and restraining cancer, and the like. The gingko wine has remarkable economic benefit and social benefit.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, haw thorn, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention provides a novel traditional Chinese medicinal compound Subing (quick effect heart rescue) spraying agent and its preparation method and belongs to the field of biomedicine, wherein the Subing (quick effect heart rescue) spraying agent has a good curative effect of resisting coronary angina pectoris. The problem of dissolving borneol with levant storax oil is solved by a new technology and a new method. The prescription is composed of styrax, borneol, a solubiliser, an absorption enhancer and a solvent. By the simple new technology of dissolution, homogenization and the like, borneol which is completely insoluble in water and levant storax oil which is not miscible with water phase are dissolved together in an oral water-soluble base so as to obtain an oral solution which is uniform and transparent without layers and suspension. The spraying agent or aerosol prepared in the invention can be quantitatively and directly sprayed into mouth or sprayed under tongue or directly sprayed into nasal cavity. In comparison with a solid preparation, the spraying agent prepared by styrax and borneol for oral administration has advantages of fast absorption and rapid effect, can perform a curative effect better and faster, is applicable to be taken by patients with angina pectoris during the acute phase. By the adoption of the preparation method provided by the invention, the effect onset time is greatly shortened within 60 seconds. The preparation method provides a good therapeutic novel medicine for currently high frequency and high occurrence of heart disease in our country.

The invention relates to a composition and a preparation process, a testing process and an application thereof. The composition comprises a therapeutically effective amount of candesartan or pharmaceutically acceptable ester or salt, a therapeutically effective amount of amlodipine or other pharmaceutically acceptable salt, 70-150 parts of mannitol or lactose, 2-5 parts of croscarmellose sodium or cross-calcium carboxymethyl cellulose and 5-40 parts of microcrystalline cellulose or corn starch. The composition is easy to prepare, low in production cost, utilizes accessories of unique prescription, and the like, can be prepared into oral preparation in forms of tablets, capsules, granules and the like by means of pharmaceutics, can be checked by different checking processes, has high quality, has functions of treating hypertension, angina pectoris and kidney diseases and has effect of myocardial protection.

A Chinese medicine for preventing and treating coronary heart disease and angina pectoris, and protecitng the cerebral ischemic injury is prepared from ginkgo leaf extract, ginseng extract, and the volatile oil of chuan-xiong or borneol.

The invention relates to extractive taking blattaria used as the medical source and being applied to the angiocarpy field, the preparation method thereof and a composition containing the extractive and pharmaceutically acceptable carrier. The extractive adopts water, alcohol and/or methanol as the extracting dissolvent, wherein, the volume concentration of the aqueous solution of the alcohol and/or methanol is 0 less than or equal to V/V less than or equal to 60 percent. The extractive has the advantages that blood fat is reduced, cholesterin is reduced, angina pectoris is prevented, the heart is tonified, and heart failure is resisted. The extraction process of the invention is simple and highly effective, the specialization is strong, and the obtained product has high effective component content. The extractive of the invention can be produced to be the composition containing the extractive and the pharmaceutically acceptable carrier.

The invention provides new uses for specific binders to the Al domain of the von Willebrand Factor (vWF), in particular the use in patients with stable angina undergoing elective percutaneous coronary intervention. Furthermore, dosing schedules and use of suitable assays such as RIPA and RICO in the particular disease settings are provided.

The invention discloses a traditional Chinese medicinal composition for treating cardiovascular diseases and belongs to the field of traditional Chinese medicaments. The traditional Chinese medicinal composition is prepared by the following steps of: extracting active ingredients from raw material medicaments, such as pericarpium trichosanthis, longstamen onion bulb, szechuan lovage rhizome and the like, by adopting the methods of different-concentration ethanol extraction, water extraction and the like respectively according to different properties of the medicaments; and preparing dropping pills, soft capsules, capsules, tablets and pills. The traditional Chinese medicinal composition is clinically used for treating diseases such as a coronary heart disease, angina pectoris, hyperlipidaemia, atherosclerosis and the like. The invention also discloses a preparation method of the traditional Chinese medicinal composition.

The present invention discloses a medicine composition containing rhodiola root extract and ginkgo leaf extract for curing angiocardiopathy and cerebrovascular diseases of cerebral apoplexy, coronary heart disease and angina pectoris, etc. Said medicine composition can be made into oral tablet, capsule, granules and injection preparation.

The invention relates to an amlodipine series salt, which particularly comprises nicotinate, camsilate, pyroglutamate, L-aspartate, maleate and mesylate. The invention also relates to a pril compoundor a pharmaceutical composition of a medicinal salt of the pril compound and a preparation method thereof, and a drug combination medicine box containing a composition of the amlodipine series salt and a composition of sartan compounds. The composition of the invention comprises the following components: a) a certain amount of an amlodipine salt; b) a certain amount of the pril compound or a medicinal salt of the pril compound; and c) a medicinal carrier or a diluting agent. The composition or the medicine box can be used for treating the patients suffering from hypertension, angina pectoris,atherosclerosis, and/or hypersphyxia and treating the patients (including the human beings) having heart danger symptoms.