A zwitterionic
polymer coating with surface
grafting crosslinking, its preparation method and application are disclosed, which relate to
surface modification of biomedical materials, pipelines and other
medical equipment, such as
extracorporeal blood circulation devices, artificial blood vessels, catheters, endoscopes and other
medical equipment, to provide functions such as anticoagulation and anti-
biological adhesion. The disclosure constructs the zwitterionic
polymer coating with simple process and excellent performance by simulating the structure of the
blood vessel intima, having the surface micro-nano structure similar to the
blood vessel intima, extremely
low friction coefficient, soft elasticity and super hydrophilicity, realizing zero activation and zero adhesion of blood platelets, further providing the
blood circulation effect of “blood undisturbed”, which is beneficial to avoiding the problems of
thrombus of artificial blood vessels
in vivo, various complications caused by clinical blood
extracorporeal circulation and the like, and has great clinical application value.