Wound closure material

A technology of polymer materials and products, applied in the field of polymer materials products, can solve the problems of material damage, fracture or tearing, etc.

Inactive Publication Date: 2011-01-05
COVIDIEN LP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While braces can be used in conjunction with stapling devices and sutures to enhance wound closure, the unidirectionally oriented materials described above tend to break or tear when little force is applied
In addition, when a staple or needle passes through these materials, the tear can prolong in a direction parallel to the unidirectional orientation, causing the material to fail prematurely when a force is applied perpendicular to the orientation of the polymer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084]Films were prepared from a polymer comprising about 60 wt% glycolide, about 14 wt% de-p-dioxanone, and about 26 wt% trimethylene carbonate. The polymer pellets were placed in a hot water press (Carver Laboratory Press, Model 2626). The heated press is heated to a temperature of about 125-165°C. The particles were placed in the center of a polytetrafluoroethylene-coated stainless steel hot press plate with stainless steel shims to control the thickness of the resulting film. The pellets are melted and spread onto the heated platen, applying a pressure of less than about 100 psi to the polymer melt. All equipment is rapidly cooled by running water passing through the hot plate. Films with a thickness of approximately 0.002 inches to 0.012 inches were obtained. The film is multidirectionally oriented.

Embodiment 2

[0086] Membranes were prepared using a random copolymer comprising about 17 wt% caprolactone, about 7 wt% lactide, about 7 wt% trimethylene carbonate, and about 69 wt% glycolide. The copolymer was extruded through a slot die from a 3 / 4 inch general purpose extruder. Thick tapes were made. The resulting tape was placed on a Teflon-coated stainless steel hot plate with appropriate spacers in a hot water press as described in Example 1 to produce a film of the desired thickness. The heated press is heated to about 105-120°C and a pressure of less than about 100 psi is applied. Similar to the film prepared using the particles in Example 1, the film produced by this method had a thickness of about 0.002 inches to 0.012 inches. Because the extruded film has a less crystalline structure than the pellets of Example 1, lower temperatures can be used to form polymer streams. The film is multidirectionally oriented.

Embodiment 3

[0088] Films were prepared from the polymers described in Example 2 using the blown film method. Incorporate polymer particles into the

[0089] in a rod / barrel configuration and jacketed extruder (Randcastle Extrusion System, Inc., Cedar Grove, New Jersey) equipped with external heating elements. The barrel had three zones set at three different temperatures, zone 1 being the part of the barrel closest to where the polymer pellets were introduced, zone 2 being the middle part of the barrel, and zone 3 being the tail end of the barrel from where the polymer was extruded . The barrel has a length / diameter ratio of 24 to 1 and a 3 / 4 inch rod is provided inside the barrel. A die, approximately 1.25 inches in diameter, was placed at the end of the barrel from which the polymer melt was extruded.

[0090] The barrel temperature in zone 1 is about 344°F; the temperature in zone 2 is about 347°F-350°F; the temperature in zone 3 is about 294°F; the temperature of the adapter betwee...

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Abstract

Articles are provided having no orientation or a multi-directional orientation. Such articles may be in the form of films, ribbons, sheets, and / or tapes and may be utilized as buttresses with a surgical stapling apparatus or as reinforcing means for suture lines. The articles may be produced with a polymeric material having an agent, such as a chemotherapeutic agent or a radiotherapeutic agent, incorporated therein or applied as a coating thereon.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of International Application No. PCT / US08 / 02978, filed March 5, 2008, which claims U.S. Provisional Patent No. 60 / 905,532, filed March 6, 2007 Claims of Claim and Priority to Applications, and the entire disclosures of each application are hereby incorporated by reference. technical field [0003] The present disclosure relates to articles of polymeric material in the form of tapes, strips, sheets and / or films. Forming these polymeric materials so that they are not oriented or multi-directionally oriented increases the integrity of the polymeric material when multi-directional forces are applied thereto. The polymeric materials of the present disclosure can be used in a variety of applications including, in some embodiments, as surgical supports or reinforcement strips for staples or sutures. Background technique [0004] Films, strips, sheets and tapes etc. made of polymeri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/16A61L33/06A61B17/068A61B17/03B29C55/10C08G63/64C08G63/664C08L67/04
CPCA61B17/072A61L2300/44A61L2300/416A61B2017/00893A61L31/10A61B2017/00526A61B17/07292A61L31/16C08L67/04
Inventor 乔舒亚·施托佩克阿明·叶拉奇查毕罗兰·奥斯塔波夫布赖恩·嫩特威克理查德·史蒂文森
Owner COVIDIEN LP
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