510results about "Antithrombogenic treatment" patented technology

A zwitterionic polymer coating with surface grafting crosslinking, its preparation method and application are disclosed, which relate to surface modification of biomedical materials, pipelines and other medical equipment, such as extracorporeal blood circulation devices, artificial blood vessels, catheters, endoscopes and other medical equipment, to provide functions such as anticoagulation and anti-biological adhesion. The disclosure constructs the zwitterionic polymer coating with simple process and excellent performance by simulating the structure of the blood vessel intima, having the surface micro-nano structure similar to the blood vessel intima, extremely low friction coefficient, soft elasticity and super hydrophilicity, realizing zero activation and zero adhesion of blood platelets, further providing the blood circulation effect of “blood undisturbed”, which is beneficial to avoiding the problems of thrombus of artificial blood vessels in vivo, various complications caused by clinical blood extracorporeal circulation and the like, and has great clinical application value.

The invention discloses an epoxy group modified zwitterionic polymer / heparin composite coating and a preparation method thereof. The preparation method comprises the following steps: firstly, constructing an amino-containing adhesion layer on the surface of a substrate by adopting a dip-coating method; then, the substrate is soaked in a mixed solution of the zwitterionic polymer and the heparin, and grafting of the zwitterionic polymer and the heparin on the surface of the medical material is completed through incubation. The coating provided by the invention has excellent hydrophilicity, can form a hydration layer, provides a physical barrier, and remarkably prevents adhesion and colonization of microorganisms. The inhibition rate of the coating on escherichia coli and staphylococcus aureus exceeds 99%, protein adhesion is remarkably reduced in an anti-protein adhesion experiment, and the coating is simple in strategy design, has a potential application prospect in the aspect of preventing blood contact catheter related infection and thrombosis, and has a wide application prospect. The complication occurrence rate and the medical care cost can be reduced.

The invention provides an anticoagulant coating for medical instruments, which can be used in the field of regenerative medical instruments. The prepared anticoagulant coating has short-term and long-term anticoagulant performance, and in addition, the thrombin responsive nanoparticles wrapped in the hydrogel coating can selectively release a factor Xa (FXa) inhibitor apixaban according to needs, so that thrombosis is inhibited in the middle stage of implantation. In-vitro and in-vivo experimental evidences show that after the material is implanted for a long time, an organized endodermis can be seen on the surface of the material, and the material has a special antithrombotic characteristic. The dynamic adjusting system has a multi-layer protection mechanism, and a new thought can be provided for designing the surface of a contact blood material adapting to environmental conditions.

The invention relates to the technical field of coating surface preparation, in particular to an anticoagulant coating based on novel tick-derived anticoagulant protein Qinghaenin and a preparation method of the anticoagulant coating. The functional layer of the anticoagulant coating comprises the following components: anticoagulant protein Qinghaenin or a functional peptide fragment Qinghaenin 167-192 of the anticoagulant protein Qinghaenin, wherein the amino acid sequence of the functional peptide fragment is as shown in SEQ ID NO. 2. The preparation method of the anticoagulant coating comprises the following steps: by using a polydopamine coating as a substrate layer, covalently grafting through an amido bond, immobilizing anticoagulant protein Qinghaenin capable of inhibiting FXII factor activation or a functional peptide fragment Qinghaenin 167-192 thereof on the surface of a medical polymer material, and successfully constructing a novel anticoagulant coating. Compared with an unmodified medical polymer material, the modified coating can significantly enhance the hydrophilic performance of the material and inhibit platelet adhesion and activation, finally effectively prolongs the in-vitro blood coagulation time, and shows excellent anticoagulation performance.

A type of additive based on a fluorinated carbamate prepolymer, a preparation method therefor, and a use thereof in the preparation of a medical fluorinated anticoagulant polyurethane material. The preparation method of the additive comprises: reacting a polyester / polyether diol, a diisocyanate and a fluorinated small-molecule diol, to obtain a carbamate prepolymer having an isocyanate end group, and then capping with a monohydric alcohol having a fluorinated carbon chain, to obtain an additive based on a fluorinated carbamate prepolymer. The additive has a high fluorine content. After being blended with a polyurethane masterbatch, fluorine atoms having low surface energy can be enriched on the surface of the material, and the fluorine atom content on the surface of the material can be as high as 60%. This effectively reduces the adhesion of plasma proteins, cells and platelets on the surface of the material, providing the medical polyurethane material with an excellent anticoagulant effect. In addition, it maintains the excellent mechanical properties of polyurethane, and is thus widely applicable in the preparation of medical fluorinated anticoagulant polyurethane materials.

To provide: a method for producing an anti-thrombogenic material in which white turbidity is reduced; a method for producing a medical instrument coated with the anti-thrombogenic material produced by the method; and an anti-thrombogenic material in which white turbidity is reduced.SOLUTION: A method for producing an anti-thrombogenic material according to the present invention comprises a step of copolymerizing a specific alkyl (meth)acrylate, a silicone (meth)acrylate, and an alkoxy polyethylene glycol (meth)acrylate, wherein the silicone (meth)acrylate used here has a weight average molecular weight of 1450 or less.SELECTED DRAWING: None

According to the scheme, the expanded polytetrafluoroethylene artificial blood vessel with the anticoagulant coating and preparation and application are provided, firstly, groups such as carboxyl and amino are formed on the inner surface of the expanded polytetrafluoroethylene artificial blood vessel through co-auto-polymerization reaction of L-dopamine and polyethyleneimine in a Tris aqueous alkali, then epoxy chloropropane serves as a cross-linking agent, and the expanded polytetrafluoroethylene artificial blood vessel with the anticoagulant coating is prepared. Trihydroxymethyl methylamino propanesulfonic acid is cross-linked to the inner surface of the membrane, carboxyl and sulfonic acid groups on the surface of the membrane endow the expanded polytetrafluoroethylene artificial blood vessel with anticoagulation performance, meanwhile, the hydrophobic performance of the outer surface is reserved, anticoagulation finishing is conducted on the inner wall of the expanded polytetrafluoroethylene artificial blood vessel, and the hydrophobic performance of the outer wall of the blood vessel is reserved; the expanded polytetrafluoroethylene artificial blood vessel has an anticoagulation function and does not influence the growth of fiber cells and fiber connective tissues on the surface of the blood vessel.

The invention belongs to the technical field of heparin anticoagulant coatings, and particularly relates to a long-acting heparin anticoagulant coating and a preparation method thereof. The long-acting heparin anticoagulation coating is formed by curing a long-acting heparin anticoagulation coating, and the long-acting heparin anticoagulation coating comprises a component A and a component B; the raw materials of the component A comprise at least one of a monomer, an initiator, a polymer, poly-L-lysine hydrobromide, streptavidin, sodium hyaluronate and crotonaldehyde; wherein the monomer comprises at least one of MPC, PEGMA and SBMA, and the polymer comprises an amino substrate; the raw materials of the component B comprise at least one of a reducing agent and heparin. The preparation method comprises the following steps: circulating the long-acting heparin anticoagulant coating in an ECMO system, and curing to obtain the long-acting heparin anticoagulant coating. The long-acting heparin anticoagulant coating constructed by the invention can realize a lasting and stable anticoagulant effect in an ECMO system, and can overcome the defects in the prior art.

The invention provides a medical stent and a preparation method thereof.The preparation method comprises the steps that an anti-coagulation coating is arranged on at least part of the surface of the medical stent through physical coating, then an anti-hyperplasia coating is arranged on at least part of the surface of the medical stent through physical coating, the anti-coagulation coating comprises a copolymer, and the anti-hyperplasia coating comprises an anti-hyperplasia coating. A copolymer in the anticoagulant coating contains a zwitterionic unit and an adsorption unit, and the anti-hyperplasia coating contains an anti-hyperplasia drug and a degradable polymer; or, an anti-hyperplasia and anti-coagulation integrated coating is arranged on at least part of the surface of the medical stent through physical coating, the integrated coating contains a copolymer and an anti-hyperplasia drug, and the copolymer in the integrated coating contains a zwitter-ion unit, an adsorption unit and a degradable unit; the adsorption unit is an ester unit containing a carbon-carbon double bond, and the degradable unit is a 2-methylene-1, 3-dioxane unit. The problem that thrombus and restenosis exist at the same time after the stent is implanted can be solved, the binding force between the coating and the substrate is improved, and the falling risk of the coating is reduced.

A composition for the surface treatment of a polymer material includes a hyperbranched polyglycerol comprising a glycidol-derived repeating unit and an unsubstituted or substituted acrylate group at least at one end thereof. The composition has the effect of suppressing fibrosis, thrombus formation, or inflammatory cell adsorption by preventing proteins from being adsorbed to the surface of a polymer material that is surface-treated with the composition or an in-vivo implantation material including a polymer material.

The invention discloses a central venous catheter coating formula and a preparation method thereof.The coating comprises a bottom coating and a top coating, the top coating covers the bottom coating, and the bottom coating comprises, by weight, 50-60 parts of a primer, 1.5-2 parts of a cross-linking agent A, 25-30 parts of ethyl alcohol and 25-30 parts of purified water; the formula of the top-layer coating comprises 100-120 parts by weight of a top coating agent, 1-3 parts by weight of a cross-linking agent B and 100-200 parts by weight of purified water, and the formula of the bottom-layer coating and the formula of the top-layer coating are anti-sticking, hydrophilic and lubricating; the bottom coating has the effect of enhancing adhesive force and is firmly bonded with the base material, and the top coating is combined with the bottom coating through temperature crosslinking, has hydrophilic lubrication and anticoagulation functions and is firmly combined with the base material of the central venous catheter to form the coating with good biocompatibility and antithrombotic effect.

The invention discloses a photocuring hydrogel anticoagulant coating and a preparation method thereof, and belongs to the technical field of biomedicine. The preparation method comprises the following steps: firstly, preparing methacrylated polyvinyl alcohol, methacrylated heparin, a photoinitiator and water into a uniform coating dipping solution, dipping a substrate with a clean surface into the coating dipping solution for 5-100 minutes, taking out the substrate, airing, repeatedly dipping for 2-10 times, and curing the obtained substrate under ultraviolet excitation light to obtain the coating. The preparation process of the photocuring hydrogel anticoagulant coating is simple and easy to operate, the reaction condition is mild, and the prepared photocuring hydrogel anticoagulant coating has very good biocompatibility, can be firmly combined with a substrate material, has very excellent anticoagulant performance and has very good application prospects.

The invention discloses a synergistic dual-mode anticoagulation and anti-inflammatory central venous catheter BC-BCD double-layer bionic hydrogel coating and a preparation method thereof. BSA / CBAA hydrogel formed by copolymerizing bovine serum albumin and carboxyl betaine acrylamide is used as an outer coating of the catheter, dopamine containing catechol groups is introduced as a main chain network, and BSA / CBAA / DA hydrogel is obtained and used as an inner coating of the catheter. The two layers are combined through a two-step impregnation method to obtain the BC-BCD double-layer bionic coating, thrombus can be defended on a catheter interface in an active mode and a passive mode, oxidation factors in a body can be removed, oxidative stress and bacterial infection can be reduced, and the BC-BCD double-layer bionic coating can be tightly attached to a base material. Experimental results show that the prepared bionic hydrogel coating has excellent anticoagulation and anti-inflammatory performance and long-term stable adhesion performance, the main defects of a traditional central venous catheter are remarkably overcome, and the bionic hydrogel coating has a positive effect on clinical prevention of thrombus and infection.

The invention belongs to the technical field of biomedical materials, and particularly relates to a poly-4-methyl-1-pentene (PMP) gas-blood exchange membrane for an extracorporeal membrane oxygenation (ECMO) system, which realizes a long-acting antithrombotic function through a bionic interface construction technology. The invention aims to provide a bionic antithrombotic PMP gas-blood exchange membrane based on zwitter-ion gradient grafting, and through material and process innovation, the following problems existing in a traditional ECMO gas-blood exchange membrane: an antithrombotic coating is easy to fall off, and the long-term effect is insufficient; the risk of blood injury caused by dependence on heparin or anticoagulants; and the surface modification process destroys the membrane pore structure and air permeability.

The invention relates to an anticoagulant medical device and a preparation method thereof. The preparation method of the anticoagulant medical device comprises the following steps: covalently connecting the hydrophilic anticoagulant layer on the surface of the base material in an atom transfer radical polymerization manner; a heparin anticoagulation layer is covalently connected to the surface of a hydrophilic anticoagulation layer to prepare the anticoagulation medical device, and the heparin anticoagulation layer and the hydrophilic anticoagulation layer are connected through one or more covalent bonds of a triazole bond, an amido bond, a carbon-nitrogen single bond and a carbon-sulfur single bond. According to the preparation method of the anticoagulation medical device, the anti-protein adsorption effect of the hydrophilic anticoagulation layer and the anticoagulation effect of the heparin anticoagulation layer can be synergistically exerted, the anticoagulation effect is improved, and meanwhile, the anticoagulation stability is improved.

The invention relates to the field of medical instruments, in particular to a composite heparin anticoagulant coating and a preparation method thereof. The method comprises the following steps: ultraviolet light pretreatment: carrying out ultraviolet light pretreatment on a substrate material to initiate polyethyleneimine to be grafted on the surface of the material; turning coating: coating the surface of the substrate material with a heparin solution, and fixing with an EDC solution; and the coating direction is changed in the coating process. Amino chains are introduced to the surface of a substrate material through ultraviolet light, the surface is provided with positive charges, and the heparin coating is formed through ionic bond combination. After the coating is completed, the coating is fixed by using an EDC solution, and the coating direction is changed in the coating process, so that the stability, the uniformity, the hydrophilicity and the anticoagulation performance of the coating are improved.

High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces. Polymers may be entrapped in pores of materials to provide a durable modification of the materials.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The present invention addresses the problem of providing a carrier for easily introducing a medicine or the like into cells.　It was found that the problem can be solved by: a collagen-binding membrane-permeable peptide comprising a collagen-binding domain, a membrane fusion domain, and a membrane-permeable domain; and a carrier comprising said peptide and collagen or a collagen derivative. Due to the foregoing, the present disclosure was completed.

Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.

The invention discloses an intravascular stent coating as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The intravascular stent coating is obtained by reaction of a porous coating and an anion solution containing drug molecules, the porous coating contains micro-nano albumin-polypeptide particles stacked on the surface of a stent matrix, and the micro-nano albumin-polypeptide particles are formed by co-assembly of albumin and polypeptide containing hydrophobic amino acid under induction of an oxidizing agent; the porosity of the intravascular stent coating is smaller than that of the porous coating. The intravascular stent coating has excellent biocompatibility and can achieve high loading of drugs, along with degradation of the intravascular stent coating, the released polypeptide and drugs can play dual effects, and the degradation process is beneficial to prolonging the treatment effect of the intravascular stent. The intravascular stent with the intravascular stent coating can reduce or avoid inflammatory response and postoperative complications, and has high application value.

Disclosed are implants, devices and systems capable of being deployed within the neurovasculature of a subject. The implants are configured for enhanced conformability to a vessel wall and have thromboresistant design features and coatings. The devices for implant deployment are configured for precise placement of an implant, resheathing of a partially deployed implant, and reliable detachment of an implant without distorting the positioning of the implant.

Provided herein are compositions including polymeric binder or a salt thereof, high molecular weight polymer, pharmaceutically active agent and a low molecular weight cross-linking agent, methods for using the compositions to coat a substrate, and methods for making the compositions. Alternatively, the composition may include a polymeric binder or a salt thereof, high molecular weight polymer and a pharmaceutically active agent. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and / or protein binding.

The invention relates to a method for coating at least one mass exchange device (1) with an exchange chamber (2) in which at least one material-permeable membrane (3) is arranged and which is divided by the membrane (3) into a first and a second chamber area (2a, 2b), wherein a liquid coating agent (9) is filled into one of the chamber areas (2a, 2b) and deposited on the surface and / or into the pores (3a) of the membrane (3) on the side of the membrane (3) associated with the chamber area (2a, 2b), after which excess coating agent (9) is removed from the chamber area (2a, 2b), wherein a reservoir (7) containing the coating agent (9) is connected to an inlet connection (8a) of one of the chamber areas (2a, 2b), wherein the volume of the coating agent (9) entering the chamber area (2a, 2b) to be coated is smaller than the total fillable volume of the chamber area (2b).to which the reservoir (7) is connected, and by means of an acceleration force exerted on the coating agent (9) the coating agent (9) is driven as a bolus (5) from the inlet connection (8a) to an outlet connection (8b) of the chamber area (2a, 2b) along the at least one membrane (3) through the chamber area (2a, 2b), wherein the volume of the bolus (5) decreases as it passes through the chamber area (2a, 2b) due to the deposition of coating agent (9) on the surface and / or the incorporation of coating agent (9) into the pores (3a) of the membrane (3), and at the outlet connection (8b) the bolus (5) exits the chamber area (2a, 2b) with a residual volume.

A sample collection assembly, including a container having a first end with an opening therein, a second end, and an interior cavity; a stopper sealing the opening, wherein the stopper comprises a chamber and wherein the chamber is configured to receive the sample from a needle piercing the stopper; a substrate enclosing the chamber and permeable to the sample, the substrate containing an additive; and an agitator coupled to the stopper, wherein the agitator is configured to modify a fluid flow characteristic of the sample permeating through the substrate.

The invention belongs to the technical field of medical materials, and particularly relates to an antibacterial and anticoagulant dual-function coating, a preparation method thereof and a needle head with the antibacterial and anticoagulant dual-function coating. S200, a PDPA coating is prepared; s300, grafting the heparin; s400, carrying out NO (nitric oxide) loading; the antibacterial and anticoagulant bifunctional coating prepared by the method has excellent antibacterial and anticoagulant functions, is used for hemodialysis, can effectively inhibit arteriovenous needle blockage and prevent bacterial infection, and is firm in adhesion and not easy to fall off.

The invention discloses a preparation method of an anticoagulant blood contact material, which comprises the following steps: S1, dissolving a silane reagent containing different functional groups by using ethanol, immersing the blood contact material into the silane solution, and reacting for a period of time in a constant-temperature environment in a dark place for later use; s2, immersing the sample obtained in the step S1 in an ethanol solution containing 1mM of TCEP (tris (2-carboxyethyl) phosphine), reacting, fully cleaning, and carrying out vacuum drying for later use; s3, dissolving an anticoagulant with a PBS (Phosphate Buffer Solution) to obtain an anticoagulant solution for later use; and S4, immersing the sample obtained in the step S2 in the anticoagulant solution prepared in the step S3, fully reacting at a constant temperature, cleaning, and drying with nitrogen to obtain the anticoagulant blood contact material. The method is simple to operate, mild in reaction condition, green, economical, free of large equipment and convenient to popularize and use. The silane reagent is used for treating the blood contact material, so that active groups such as sulfydryl, carboxyl, amido and hydroxyl can be generated on the surface of the material in situ, and meanwhile, the hydrophilicity of the material is improved. Then, the functionalized material is immersed in an anticoagulant solution, an anticoagulant drug is fixed on the surface of the material through a mild click chemical reaction, an amidation reaction and the like, and the blood contact material is endowed with excellent anticoagulant performance.

Disclosed are polymer compositions incorporating metal nanoparticles, and medical devices or other products made therefrom. The disclosed polymer compositions can be used to form medical devices, including implantable medical devices, that have effective antimicrobial properties. The disclosed polymer compositions incorporate metal nanoparticles that function without releasing metal (e.g., silver) ions. The polymer compositions may have anti-UV properties conferred by the metal nanoparticles.

High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.