38results about "Antithrombogenic treatment" patented technology

Disclosed are polymer compositions incorporating metal nanoparticles, and medical devices or other products made therefrom. The disclosed polymer compositions can be used to form medical devices, including implantable medical devices, that have effective antimicrobial properties. The disclosed polymer compositions incorporate metal nanoparticles that function without releasing metal (e.g., silver) ions. The polymer compositions may have anti-UV properties conferred by the metal nanoparticles.

This invention relates to a catheter with a photo-initiated in-situ self-polymerized silver zwitterionic hydrogel coating that enhances antibacterial and antithrombotic functions. The catheter comprises a hydrogel matrix loaded / coated / attached to the catheter surface. This hydrogel matrix is ​​subjected to self-polymerization of SBMA monomers under ultraviolet light irradiation using MBA as a crosslinking agent, forming a three-dimensional crosslinked network while simultaneously embedding Ag NPs within the hydrogel matrix. This catheter exhibits both antibacterial and antithrombotic functions.

The present application relates to the technical field of stent preparation, and particularly relates to an anticoagulant and anti-cell proliferation multifunctional coating, a preparation method thereof and a stent, and provides an anticoagulant and anti-cell proliferation multifunctional coating, which comprises a stent inner layer coating and a stent outer layer coating; the stent inner layer coating is Mirococept, polycaprolactone, heparin, an emulsifying agent, and the rest is an azidobenzoyl chitosan solution; the stent outer layer coating is astragaloside IV, everolimus, puerarin-6''-O-xyloside, an emulsifying agent, and the rest is an azidobenzoyl chitosan solution. Experimental data provided by the present application fully verify the significant advantages of the coating in terms of antithrombosis, inhibition of cell over-proliferation, regulation of inflammatory response and long-term safety, and the coating has a good application prospect.

The present invention relates to a composition for surface treatment of polymeric materials, and more specifically, the composition contains a hyperbranched polyglycerol having a repeating unit derived from glycidol and containing an unsubstituted or substituted acrylate group at at least one end, thereby preventing protein adsorption on the surface of a polymeric material or an internal implant material containing a polymeric material that has been surface-treated with the composition, and has the effect of inhibiting fibrosis, thrombus formation, or the adsorption of inflammatory cells.

This disclosure describes lipid polymer hybrid nanoparticles and methods for synthesizing such nanoparticles or compositions containing such nanoparticles. The nanoparticles are prepared in a biodegradable polymer micelle core surrounded by a lipid shell, and the majority of the pharmaceutical product is present on the inner periphery of such nanoparticles due to physical adhesion with lipid molecules. Only a small amount of the pharmaceutical product is encapsulated in the micelle core. Thus, the lipid shell becomes the primary excipient portion of the nanoparticle, and the biodegradable polymer-containing core becomes the secondary excipient portion of the nanoparticle.

This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.

Devices, systems, methods, and compositions are provided herein, each comprising a composition for coupling to the surface of an implantable article, wherein the composition comprises an anticoagulant comprising a direct factor Xa inhibitor, and at least one of (a) an antiplatelet agent, (b) an anticoagulant comprising a direct factor IIa inhibitor, and (c) an anti-inflammatory agent comprising colchicine. The disclosed technology provides compositions for coupling to the surface of an implantable article, typically a vascular implant, such as a stent, stent-graft, prosthetic valve, or occlusion device.

The application provides a multilayer polymer biomimetic membrane for dura mater repair and a preparation method thereof. The biomimetic membrane comprises a three-layer biomimetic nanofiber composite structure: a cell adhesion inner layer on the side facing the brain tissue, an anti-adhesion outer layer on the side facing the skull, and an intermediate reinforcing layer between the cell adhesion inner layer and the anti-adhesion outer layer. The cell adhesion inner layer is a PCL / chitosan / collagen composite fiber layer, the intermediate reinforcing layer is a PCL / hydroxyapatite composite fiber layer, and the anti-adhesion outer layer is a PCL / polylactic acid-hydroxyacetic acid copolymer (PLGA) layer. The method comprises cell adhesion inner layer preparation, intermediate reinforcing layer preparation, anti-adhesion outer layer preparation, and continuous production processing. The application obtains a multilayer artificial dura mater with strong interlayer bonding, high adhesion, and biomimetic mechanical properties.

Provided are an instrument and a coating agent for use in blood vessels, which can be stably supplied, have excellent suppression of clot formation, and are unlikely to inhibit vascular endothelialization. The instrument according to the present invention comprises a base material and a coating layer that covers at least a part of the surface of the base material, and is intended to be used in a blood vessel. The coating layer has a monomolecular layer formed by treating the surface of the base material with a low-molecular-weight compound having a functional group such as an albumin-binding functional group, and satisfies at least one of predetermined requirements.

This invention discloses a composite anticoagulant coating, its preparation method, and its applications, belonging to the field of biomedical technology. This invention provides a novel composite anticoagulant coating. Through the following innovative design: using multi-thiol proteins (bovine serum albumin, lysozyme, etc.) as coating substrates, in-situ bio-orthogonal multiple grafting is performed on their thiol groups and amino groups to achieve multifunctionality of anticoagulation, anti-inflammation, and antibacterial properties; through the amyloid aggregation of proteins, a strong target substrate is formed and anchored, resisting blood flow impact and improving coating stability. This invention, through bio-orthogonal design, modifies the thiol groups and amino groups of the coating proteins separately to achieve non-conflicting multifunctionality. Specifically, by modifying the disulfide bonds (-S-S-) and branched amino groups (-NH2) of the proteins, dual active sites of -SH and -GA are constructed for grafting modification, allowing the grafted substances to achieve their multifunctionality of anticoagulation, anti-inflammation, and antibacterial properties without interference.

The application belongs to the technical field of biology and specifically relates to application of a functional peptide segment derived from an anticoagulant protein Qinghaienin in anticoagulation. The peptide segment is derived from an anticoagulant protein Qinghaienin of Haemaphysalis qinghaiensis. The peptide segment is coated on the surface of a medical polymer material through polydopamine-mediated grafting modification technology, and a new type of anticoagulant coating is successfully constructed. Compared with the unmodified medical polymer material, the modified coating can significantly enhance the hydrophilic property of the material and inhibit platelet adhesion and activation, and finally effectively prolong the blood clotting time in vitro, and exhibits excellent anticoagulant performance. Compared with the anticoagulant coating made of complete Qinghaienin protein, the anticoagulant coating made of the peptide segment induces less inflammatory response.

The application provides a rare earth-based anticoagulant material and a preparation method and application thereof, and the rare earth-based anticoagulant material comprises a polymer matrix and a composite rare earth functional component, the composite rare earth functional component comprises lanthanum-doped bioactive glass functional particles and cerium oxide functional particles, the addition amount of the lanthanum-doped bioactive glass functional particles is 0.5%-5.0% of the mass of the polymer matrix, the addition amount of the cerium oxide functional particles is 0.1%-1.0% of the mass of the polymer matrix, the polymer matrix is a blend of poly(epsilon-caprolactone) and poly(L-lactic acid), and the mass ratio of the poly(epsilon-caprolactone) to the poly(L-lactic acid) is (6-9):(1-4). The material not only provides efficient anticoagulant function, but also has significant antioxidant and anti-inflammatory properties.

Provided is an antithrombotic coating material containing a polyorganosiloxane having at least one of an oxiranyl group and an oxetanyl group, thereby forming a coating film having excellent adhesion to a substrate while exhibiting good antithrombotic properties.

Provided are an instrument and a coating agent for use in blood vessels, which can be stably supplied, have excellent suppression of thrombus formation, and are unlikely to inhibit vascular endothelialization.　The instrument according to the present invention comprises a base material and a coating layer that covers at least a part of the surface of the base material, and is intended to be used in a blood vessel. The coating layer has a monomolecular layer formed by treating the surface of the base material with a low-molecular-weight compound having a functional group such as an albumin-binding functional group, and satisfies at least one of predetermined requirements.

This invention discloses a method for surface-modified biomaterials and a modified pericardial material, relating to the field of biomedical materials technology. The method includes the following steps: S1, providing animal pericardial material cross-linked with glutaraldehyde; providing a bridging molecule containing a first bridging group and a second bridging group, and a phosphorylcholine polymer with a third bridging group at its end; binding the first bridging group to an aldehyde group on the surface of the pericardial material via a first covalent reaction; binding the second bridging group to the third bridging group via a second covalent reaction, thereby achieving grafting of the phosphorylcholine polymer onto the material surface; the first covalent reaction and / or the second covalent reaction include Schiff base formation and reductive amination processes. The modified pericardial material prepared in this application introduces a phosphorylcholine biomimetic coating, which can improve blood compatibility on the material surface, reduce activation of the coagulation system and platelet adhesion, and inhibit the initiation of calcium ion deposition on the material surface, while exhibiting high safety.

The invention belongs to the field of functional medical catheter preparation, and particularly relates to an antibacterial and anticoagulant dialysis catheter with a sodium alginate-graphene oxide coating and a preparation method of the antibacterial and anticoagulant dialysis catheter. The preparation method comprises the following steps: (1) mixing a graphene oxide dispersion liquid with a sodium alginate solution, then adding a water / alcohol mixed solvent, and then carrying out ultrasonic dispersion treatment to obtain a mixed solution; (2) performing plasma pretreatment on the polyurethane dialysis catheter to obtain a pretreated catheter; (3) immersing the pretreated conduit into the mixed solution, and after dip-coating is completed, sequentially standing and drying to obtain a primary gel layer conduit; and (4) immersing the primary gel layer catheter into a cross-linking solution, and then sequentially cleaning, gradient heating and curing. Efficient antibiosis and anticoagulation are achieved through the synergistic effect of materials, the coating is firm in combination and excellent in biocompatibility, the problems of thrombus formation, infection and the like of an existing dialysis catheter can be solved, and the coating is suitable for hemodialysis vascular access.

The objective of the present invention under such circumstances is to provide a method for producing an antithrombogenic material having less white turbidity, a method for producing a medical device coated with the medical device produced by the method, and a medical device having less white turbidity. The method for producing an antithrombogenic material according to the present invention is characterized in comprising the step of copolymerizing the specific alkyl (meth)acrylate, silicone (meth)acrylate and alkoxypolyethylene glycol (meth)acrylate, wherein the weight average molecular weight of the silicone (meth)acrylate is 1450 or less.

This invention provides a method for preparing a deep vein catheter and its inner and outer walls with zwitterionic hydrogel coatings. The catheter of this invention includes: a catheter substrate; an adhesive coating covering the inner and outer walls of the catheter; an inner wall coating and an outer wall coating (4); wherein the inner wall coating and the outer wall coating are respectively fixed to the inner and outer surfaces of the catheter substrate by the adhesive coating; and both are zwitterionic hydrogel coatings. By simultaneously constructing this hydration barrier on the inner and outer walls of the catheter, this invention can block platelet adhesion and coagulation pathway activation from the initial stage of thrombosis; at the same time, the semi-interpenetrating network or microgel-reinforced structure significantly improves the mechanical stability and durability of the hydrogel, making it suitable for long-term indwelling catheters.

An integrated sheath assembly for inserting fa medical device such as a percutaneous pump into a vessel can include a first sheath having a first lumen defining a first opening between proximal and distal ends of the first sheath for passage of a portion of the pump and a second sheath having a second lumen defining a second opening between proximal and distal ends of the second sheath. The second lumen is expandable to allow passage of the first sheath containing the portion of the pump. The first sheath fills a space between the second sheath and the portion of the percutaneous pump when the first sheath containing the percutaneous pump is inserted into the second lumen. Hie first sheath has a first hub, and the second sheath has a second hub. In some embodiments, a single sheath and a movable connector can be integrated on the medical device.

This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.

This application provides a coating for the surface of medical materials, its preparation method, application, and the medical materials themselves. The preparation method includes the following steps: co-depositing dopamine and a polyamino compound on the surface of the medical material to form an amino-containing adhesive layer; mixing heparin and hyaluronic acid and activating the carboxyl groups of the heparin and hyaluronic acid; contacting the amination-treated medical material with the carboxyl-activated heparin and hyaluronic acid to allow the amino groups on the surface of the medical material to undergo a covalent grafting reaction with the activated carboxyl groups of the heparin and hyaluronic acid, thereby obtaining the coating for the surface of the medical material. This coating possesses both highly efficient anticoagulant and anti-inflammatory biological activities and exhibits excellent stability.

This application discloses a drug-coated stent and its preparation method, belonging to the field of medical devices. The drug-coated stent includes: a drug-coated stent substrate; an anticoagulant coating covering the surface of the drug-coated stent substrate; an intermediate coating covering the anticoagulant coating and located on the outer surface of the drug-coated stent substrate; and a drug coating coated on the outer surface of the intermediate coating, the drug coating comprising an active drug and a controlled-release polymer controlling the release rate of the active drug; the intermediate coating and the anticoagulant coating are bonded by electrostatic adsorption. The drug-coated stent provided by this application exhibits the following advantages: the anticoagulant coating stably exerts its anticoagulant effect and reduces the risk of thrombosis; the intermediate coating enhances the bonding strength between the drug coating and the anticoagulant coating and prevents its detachment; and the drug coating enables sustained release of the active drug and inhibits restenosis. These three components synergistically address both anticoagulant and anti-restenosis effects, improving the stent's therapeutic efficacy and clinical applicability. The preparation process is simple and controllable, suitable for large-scale production.

The disclosed technology includes a method for embedding medical additives in a bioabsorbable material. This method may involve chemically reacting one or more functional groups of the bioabsorbable material with one or more medical additives. The bioabsorbable material may be configured to be placed within the human body. One or more medical additives may remain chemically bonded to the foam structure of the bioabsorbable material until the biodegradation of the bioabsorbable material.

The application discloses a double-sided hydrogel scaffold for urethral repair and a preparation process thereof, and belongs to the technical field of biomaterials. The PCH@PVA scaffold is constructed, a base layer on the tissue side creates a eutrophication and guiding microenvironment for regeneration by using heparin, and a functional layer on the lumen side effectively blocks the penetration of harmful components in urine and the colonization of bacteria by a polyvinyl alcohol coating, and by optimizing the crosslinking degree of PVA, the PVA has excellent mechanical toughness and elasticity, can not only withstand the periodic expansion of the urethra without breaking, but also can transmit mechanical stimulation close to the physiological range, guide cells to functional regeneration instead of pathological fibrosis. The PCH@PVA scaffold provided by the application has excellent effects in promoting re-epithelialization, angiogenesis, inhibiting fibrosis and preventing stenosis. The application also provides a new design paradigm and theoretical basis for tissue regeneration strategies in other complex physiological microenvironments.

The present application relates to the technical field of medical stents, and discloses a heparin coating and a preparation method, a vascular heparin covered stent and a preparation method, the heparin coating is prepared by introducing a photo-reactive group on a heparin molecule through substrate pretreatment, heparin modification, ultraviolet light curing and other modes, and the process does not use toxic reagents; the vascular covered stent comprises a wavy spiral, a flexible and stretchable stent body, an inner stent cylinder film and an outer silk stent covered film, a coating is coated on the inner surface of the cylinder film and the outer surface of the covered film, the vascular environment of long-distance and repeated bending of lower limbs can be met, the heparin coating is firmly combined, has long-lasting anticoagulation, effectively inhibits thrombosis, and greatly improves the safety and service life of the stent.

To provide absorbable block copolymers with improved characteristics including thermal stability, molecular weight consistency, and inherent viscosity retention following melt extrusion, and uses thereof.SOLUTION: A polymer includes a polyaxial core, with at least three axes, and a pre-polymer. The at least three axes comprise polymeric chains. There is also at least one flexible linking segment. Further, at least one polymeric end graft is attached to each of the at least three axes, and comprises repeat units derived from at least one cyclic monomer capable of crystallization.SELECTED DRAWING: Figure 6A

A method for producing high strength hydrophilic nanoporous biomaterials for medical devices is provided. [Solution] A method for producing a hydrophilic material includes heating a mixture comprising at least one water-soluble polymer and a solvent to a temperature above the melting point of the polymer, forming the mixture, and passing the formed mixture through a solvent removal environment.

This invention relates to a medical device comprising at least one substrate having a coating, wherein the coating includes a functional layer situated on the substrate, wherein the functional layer comprises at least one sugar alcohol and is directly or indirectly bound to the substrate through the functionalization of the sugar alcohol. Optionally, the functional layer may also comprise other sugars, in which case it is crucial that the sugars polymerize only when bound to the substrate. The medical device of this invention exhibits reduced platelet adhesion and aggregation.

A medical device, which includes: a base material; an antithrombogenic layer including a polymer fixed to the base material, in which the polymer includes: a structural unit a derived from a first monomer bonded to the base material and including a reactive group that reacts with a hydroxyl group or a carboxyl group and an ethylenically unsaturated group; a structural unit B including a polymer chain including a structural unit b derived from a first antithrombogenic monomer including a carboxyl group and an ethylenically unsaturated group, and including a terminal of the polymer chain bonded to the structural unit a; and a structural unit C derived from a copolymer including a structural unit c1 derived from a second monomer including an amino group and bonded to the structural unit b and a structural unit c2 derived from a second antithrombogenic monomer.

Provided is a novel biocompatible polymer.　This polymer compound has a chain ether structure in a side chain and has a specific branched structure in this chain ether structure.