365results about "Antithrombogenic treatment" patented technology

The invention provides an anticoagulant coating for medical instruments, which can be used in the field of regenerative medical instruments. The prepared anticoagulant coating has short-term and long-term anticoagulant performance, and in addition, the thrombin responsive nanoparticles wrapped in the hydrogel coating can selectively release a factor Xa (FXa) inhibitor apixaban according to needs, so that thrombosis is inhibited in the middle stage of implantation. In-vitro and in-vivo experimental evidences show that after the material is implanted for a long time, an organized endodermis can be seen on the surface of the material, and the material has a special antithrombotic characteristic. The dynamic adjusting system has a multi-layer protection mechanism, and a new thought can be provided for designing the surface of a contact blood material adapting to environmental conditions.

The invention relates to the technical field of coating surface preparation, in particular to an anticoagulant coating based on novel tick-derived anticoagulant protein Qinghaenin and a preparation method of the anticoagulant coating. The functional layer of the anticoagulant coating comprises the following components: anticoagulant protein Qinghaenin or a functional peptide fragment Qinghaenin 167-192 of the anticoagulant protein Qinghaenin, wherein the amino acid sequence of the functional peptide fragment is as shown in SEQ ID NO. 2. The preparation method of the anticoagulant coating comprises the following steps: by using a polydopamine coating as a substrate layer, covalently grafting through an amido bond, immobilizing anticoagulant protein Qinghaenin capable of inhibiting FXII factor activation or a functional peptide fragment Qinghaenin 167-192 thereof on the surface of a medical polymer material, and successfully constructing a novel anticoagulant coating. Compared with an unmodified medical polymer material, the modified coating can significantly enhance the hydrophilic performance of the material and inhibit platelet adhesion and activation, finally effectively prolongs the in-vitro blood coagulation time, and shows excellent anticoagulation performance.

According to the scheme, the expanded polytetrafluoroethylene artificial blood vessel with the anticoagulant coating and preparation and application are provided, firstly, groups such as carboxyl and amino are formed on the inner surface of the expanded polytetrafluoroethylene artificial blood vessel through co-auto-polymerization reaction of L-dopamine and polyethyleneimine in a Tris aqueous alkali, then epoxy chloropropane serves as a cross-linking agent, and the expanded polytetrafluoroethylene artificial blood vessel with the anticoagulant coating is prepared. Trihydroxymethyl methylamino propanesulfonic acid is cross-linked to the inner surface of the membrane, carboxyl and sulfonic acid groups on the surface of the membrane endow the expanded polytetrafluoroethylene artificial blood vessel with anticoagulation performance, meanwhile, the hydrophobic performance of the outer surface is reserved, anticoagulation finishing is conducted on the inner wall of the expanded polytetrafluoroethylene artificial blood vessel, and the hydrophobic performance of the outer wall of the blood vessel is reserved; the expanded polytetrafluoroethylene artificial blood vessel has an anticoagulation function and does not influence the growth of fiber cells and fiber connective tissues on the surface of the blood vessel.

The invention provides a medical stent and a preparation method thereof.The preparation method comprises the steps that an anti-coagulation coating is arranged on at least part of the surface of the medical stent through physical coating, then an anti-hyperplasia coating is arranged on at least part of the surface of the medical stent through physical coating, the anti-coagulation coating comprises a copolymer, and the anti-hyperplasia coating comprises an anti-hyperplasia coating. A copolymer in the anticoagulant coating contains a zwitterionic unit and an adsorption unit, and the anti-hyperplasia coating contains an anti-hyperplasia drug and a degradable polymer; or, an anti-hyperplasia and anti-coagulation integrated coating is arranged on at least part of the surface of the medical stent through physical coating, the integrated coating contains a copolymer and an anti-hyperplasia drug, and the copolymer in the integrated coating contains a zwitter-ion unit, an adsorption unit and a degradable unit; the adsorption unit is an ester unit containing a carbon-carbon double bond, and the degradable unit is a 2-methylene-1, 3-dioxane unit. The problem that thrombus and restenosis exist at the same time after the stent is implanted can be solved, the binding force between the coating and the substrate is improved, and the falling risk of the coating is reduced.

The invention discloses a photocuring hydrogel anticoagulant coating and a preparation method thereof, and belongs to the technical field of biomedicine. The preparation method comprises the following steps: firstly, preparing methacrylated polyvinyl alcohol, methacrylated heparin, a photoinitiator and water into a uniform coating dipping solution, dipping a substrate with a clean surface into the coating dipping solution for 5-100 minutes, taking out the substrate, airing, repeatedly dipping for 2-10 times, and curing the obtained substrate under ultraviolet excitation light to obtain the coating. The preparation process of the photocuring hydrogel anticoagulant coating is simple and easy to operate, the reaction condition is mild, and the prepared photocuring hydrogel anticoagulant coating has very good biocompatibility, can be firmly combined with a substrate material, has very excellent anticoagulant performance and has very good application prospects.

The invention belongs to the technical field of biomedical materials, and particularly relates to a poly-4-methyl-1-pentene (PMP) gas-blood exchange membrane for an extracorporeal membrane oxygenation (ECMO) system, which realizes a long-acting antithrombotic function through a bionic interface construction technology. The invention aims to provide a bionic antithrombotic PMP gas-blood exchange membrane based on zwitter-ion gradient grafting, and through material and process innovation, the following problems existing in a traditional ECMO gas-blood exchange membrane: an antithrombotic coating is easy to fall off, and the long-term effect is insufficient; the risk of blood injury caused by dependence on heparin or anticoagulants; and the surface modification process destroys the membrane pore structure and air permeability.

High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces. Polymers may be entrapped in pores of materials to provide a durable modification of the materials.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The present invention addresses the problem of providing a carrier for easily introducing a medicine or the like into cells.　It was found that the problem can be solved by: a collagen-binding membrane-permeable peptide comprising a collagen-binding domain, a membrane fusion domain, and a membrane-permeable domain; and a carrier comprising said peptide and collagen or a collagen derivative. Due to the foregoing, the present disclosure was completed.

The invention discloses an intravascular stent coating as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The intravascular stent coating is obtained by reaction of a porous coating and an anion solution containing drug molecules, the porous coating contains micro-nano albumin-polypeptide particles stacked on the surface of a stent matrix, and the micro-nano albumin-polypeptide particles are formed by co-assembly of albumin and polypeptide containing hydrophobic amino acid under induction of an oxidizing agent; the porosity of the intravascular stent coating is smaller than that of the porous coating. The intravascular stent coating has excellent biocompatibility and can achieve high loading of drugs, along with degradation of the intravascular stent coating, the released polypeptide and drugs can play dual effects, and the degradation process is beneficial to prolonging the treatment effect of the intravascular stent. The intravascular stent with the intravascular stent coating can reduce or avoid inflammatory response and postoperative complications, and has high application value.

Provided herein are compositions including polymeric binder or a salt thereof, high molecular weight polymer, pharmaceutically active agent and a low molecular weight cross-linking agent, methods for using the compositions to coat a substrate, and methods for making the compositions. Alternatively, the composition may include a polymeric binder or a salt thereof, high molecular weight polymer and a pharmaceutically active agent. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and / or protein binding.

The invention relates to a method for coating at least one mass exchange device (1) with an exchange chamber (2) in which at least one material-permeable membrane (3) is arranged and which is divided by the membrane (3) into a first and a second chamber area (2a, 2b), wherein a liquid coating agent (9) is filled into one of the chamber areas (2a, 2b) and deposited on the surface and / or into the pores (3a) of the membrane (3) on the side of the membrane (3) associated with the chamber area (2a, 2b), after which excess coating agent (9) is removed from the chamber area (2a, 2b), wherein a reservoir (7) containing the coating agent (9) is connected to an inlet connection (8a) of one of the chamber areas (2a, 2b), wherein the volume of the coating agent (9) entering the chamber area (2a, 2b) to be coated is smaller than the total fillable volume of the chamber area (2b).to which the reservoir (7) is connected, and by means of an acceleration force exerted on the coating agent (9) the coating agent (9) is driven as a bolus (5) from the inlet connection (8a) to an outlet connection (8b) of the chamber area (2a, 2b) along the at least one membrane (3) through the chamber area (2a, 2b), wherein the volume of the bolus (5) decreases as it passes through the chamber area (2a, 2b) due to the deposition of coating agent (9) on the surface and / or the incorporation of coating agent (9) into the pores (3a) of the membrane (3), and at the outlet connection (8b) the bolus (5) exits the chamber area (2a, 2b) with a residual volume.

A sample collection assembly, including a container having a first end with an opening therein, a second end, and an interior cavity; a stopper sealing the opening, wherein the stopper comprises a chamber and wherein the chamber is configured to receive the sample from a needle piercing the stopper; a substrate enclosing the chamber and permeable to the sample, the substrate containing an additive; and an agitator coupled to the stopper, wherein the agitator is configured to modify a fluid flow characteristic of the sample permeating through the substrate.

The invention belongs to the technical field of medical materials, and particularly relates to an antibacterial and anticoagulant dual-function coating, a preparation method thereof and a needle head with the antibacterial and anticoagulant dual-function coating. S200, a PDPA coating is prepared; s300, grafting the heparin; s400, carrying out NO (nitric oxide) loading; the antibacterial and anticoagulant bifunctional coating prepared by the method has excellent antibacterial and anticoagulant functions, is used for hemodialysis, can effectively inhibit arteriovenous needle blockage and prevent bacterial infection, and is firm in adhesion and not easy to fall off.

The invention discloses a preparation method of an anticoagulant blood contact material, which comprises the following steps: S1, dissolving a silane reagent containing different functional groups by using ethanol, immersing the blood contact material into the silane solution, and reacting for a period of time in a constant-temperature environment in a dark place for later use; s2, immersing the sample obtained in the step S1 in an ethanol solution containing 1mM of TCEP (tris (2-carboxyethyl) phosphine), reacting, fully cleaning, and carrying out vacuum drying for later use; s3, dissolving an anticoagulant with a PBS (Phosphate Buffer Solution) to obtain an anticoagulant solution for later use; and S4, immersing the sample obtained in the step S2 in the anticoagulant solution prepared in the step S3, fully reacting at a constant temperature, cleaning, and drying with nitrogen to obtain the anticoagulant blood contact material. The method is simple to operate, mild in reaction condition, green, economical, free of large equipment and convenient to popularize and use. The silane reagent is used for treating the blood contact material, so that active groups such as sulfydryl, carboxyl, amido and hydroxyl can be generated on the surface of the material in situ, and meanwhile, the hydrophilicity of the material is improved. Then, the functionalized material is immersed in an anticoagulant solution, an anticoagulant drug is fixed on the surface of the material through a mild click chemical reaction, an amidation reaction and the like, and the blood contact material is endowed with excellent anticoagulant performance.

Disclosed are polymer compositions incorporating metal nanoparticles, and medical devices or other products made therefrom. The disclosed polymer compositions can be used to form medical devices, including implantable medical devices, that have effective antimicrobial properties. The disclosed polymer compositions incorporate metal nanoparticles that function without releasing metal (e.g., silver) ions. The polymer compositions may have anti-UV properties conferred by the metal nanoparticles.

High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.

The invention relates to a preparation method of an artificial blood vessel, the artificial blood vessel is composed of a porous support layer, a biodegradation layer and an antithrombotic layer, and the method comprises the following steps: soaking an expanded polytetrafluoroethylene substrate with silver nitrate doped polyvinyl pyrrolidone-poly-N-isopropylacrylamide to obtain the porous support layer; and then assembling a biodegradable material and an antithrombotic material as a biodegradable layer and an antithrombotic layer. The invention also relates to the artificial blood vessel prepared by the method.

Provided is a means capable of further improving antithrombotic properties in a medical instrument. This medical instrument is provided with: a base material; and an antithrombotic layer having a polymer fixed to the base material, the polymer having: a structural unit (a) bonded to the base material and derived from a first monomer having a reactive group that reacts with a hydroxyl group or a carboxyl group and an ethylenically unsaturated group; a structural unit B having a polymer chain including a structural unit b derived from a first antithrombotic monomer having a carboxyl group and an ethylenically unsaturated group, the structural unit B being obtained by bonding the structural unit a to a terminal of the polymer chain; and a structural unit C bonded to the structural unit b and derived from a copolymer having a structural unit c1 derived from a second monomer having an amino group and a structural unit c2 derived from a second antithrombotic monomer.

Disclosed is a composition comprising oxidized cellulose (OC) in powder form, wherein the OC has a carboxyl content of about 9% to about 18% by weight. Optionally, the powder is in agglomerated form. Further disclosed is a use of the composition for preventing tissue adhesions in the presence of bleeding.

This invention relates to a catheter with a photo-initiated in-situ self-polymerized silver zwitterionic hydrogel coating that enhances antibacterial and antithrombotic functions. The catheter comprises a hydrogel matrix loaded / coated / attached to the catheter surface. This hydrogel matrix is ​​subjected to self-polymerization of SBMA monomers under ultraviolet light irradiation using MBA as a crosslinking agent, forming a three-dimensional crosslinked network while simultaneously embedding Ag NPs within the hydrogel matrix. This catheter exhibits both antibacterial and antithrombotic functions.

The present invention relates to a method for preparing a multilayer heparin conjugate coating on a substrate, the method promoting good adhesion to the substrate surface and increasing the number of available heparin molecules.

The invention relates to the technical field of medical materials, and particularly discloses a heparinized polycaprolactone coating as well as a preparation method and application thereof. The preparation method of the heparinized polycaprolactone coating comprises the following steps: adding poloxamer 188 into an MES buffer solution, adding heparin, uniformly stirring, then adding EDC and NHS, and stirring for 40-120 minutes to prepare an activated heparin solution; and dropwise adding the polycaprolactone solution into the activated heparin solution, reacting at room temperature for 90-180 minutes, then dissolving the conjugate into chloroform through rotary evaporation, washing with water, drying with anhydrous MgSO4, precipitating with methanol, filtering the precipitate, and drying in vacuum at 30-40 DEG C to obtain the polycaprolactone heparin. According to the prepared heparinized polycaprolactone coating, local release of heparin is remarkably reduced, and the continuous anticoagulation effect is achieved; and the anticoagulant activity of heparin is reserved, and the coating with good stability is obtained.

Provided is a medical elongated body in which a bonding strength between a catheter shaft and a distal member is increased while the flexibility of a distal portion is maintained. A medical elongated body 1 includes a catheter shaft 10 that extends in an axial direction and is provided with an outer layer 11 and an inner layer 12, a distal member 20 that is fused to a distal side of the catheter shaft and is more flexible than the catheter shaft, in which in a cross-sectional view in the axial direction, a distal portion 12A of the inner layer intrudes in an arc outward in the radial direction from an inner surface of the distal member, and a distal portion 11A of the outer layer intrudes in an arc inward in the radial direction from an outer surface of the distal member.

The present application relates to the technical field of stent preparation, and particularly relates to an anticoagulant and anti-cell proliferation multifunctional coating, a preparation method thereof and a stent, and provides an anticoagulant and anti-cell proliferation multifunctional coating, which comprises a stent inner layer coating and a stent outer layer coating; the stent inner layer coating is Mirococept, polycaprolactone, heparin, an emulsifying agent, and the rest is an azidobenzoyl chitosan solution; the stent outer layer coating is astragaloside IV, everolimus, puerarin-6''-O-xyloside, an emulsifying agent, and the rest is an azidobenzoyl chitosan solution. Experimental data provided by the present application fully verify the significant advantages of the coating in terms of antithrombosis, inhibition of cell over-proliferation, regulation of inflammatory response and long-term safety, and the coating has a good application prospect.

According to the present invention, there is provided a resin composition containing a vinyl chloride-based polymer (A1), a plasticizer (A2), and a (meth)acrylic copolymer (B), in which the (meth)acrylic copolymer (B) is a block copolymer or a graft copolymer, which contains a monomer unit (b1) represented by Formula (1). The resin composition is suitable for manufacturing an article to which proteins do not adhere easily but which comes in contact with proteins.

The present disclosure relates to a zwitterionic polymer and the use thereof. Specifically, the present disclosure relates to a zwitterionic polymer, the use thereof as a biocompatible implantable material coating, and a method for preparing the coating. The coating can be used for inhibiting platelet aggregation and platelet adhesiveness caused by the exposure of blood to the surface of a material.

The present invention relates to a paintable hydrogel system. The hydrogel system possesses adhesive properties and carries therapeutic factors. According to the present invention, the hydrogel system overcomes limitations such as tissue damage and fibrosis associated with methods for delivering a substance for injection or patch-type treatment, and can be applied without limitation to the shape and size of a target site. In addition, the system can be easily and stably applied in transplantation fields involving synthetic drugs, stem cells, healthcare electronic devices, etc.