716results about "Antithrombogenic treatment" patented technology

A zwitterionic polymer coating with surface grafting crosslinking, its preparation method and application are disclosed, which relate to surface modification of biomedical materials, pipelines and other medical equipment, such as extracorporeal blood circulation devices, artificial blood vessels, catheters, endoscopes and other medical equipment, to provide functions such as anticoagulation and anti-biological adhesion. The disclosure constructs the zwitterionic polymer coating with simple process and excellent performance by simulating the structure of the blood vessel intima, having the surface micro-nano structure similar to the blood vessel intima, extremely low friction coefficient, soft elasticity and super hydrophilicity, realizing zero activation and zero adhesion of blood platelets, further providing the blood circulation effect of “blood undisturbed”, which is beneficial to avoiding the problems of thrombus of artificial blood vessels in vivo, various complications caused by clinical blood extracorporeal circulation and the like, and has great clinical application value.

The invention discloses an epoxy group modified zwitterionic polymer / heparin composite coating and a preparation method thereof. The preparation method comprises the following steps: firstly, constructing an amino-containing adhesion layer on the surface of a substrate by adopting a dip-coating method; then, the substrate is soaked in a mixed solution of the zwitterionic polymer and the heparin, and grafting of the zwitterionic polymer and the heparin on the surface of the medical material is completed through incubation. The coating provided by the invention has excellent hydrophilicity, can form a hydration layer, provides a physical barrier, and remarkably prevents adhesion and colonization of microorganisms. The inhibition rate of the coating on escherichia coli and staphylococcus aureus exceeds 99%, protein adhesion is remarkably reduced in an anti-protein adhesion experiment, and the coating is simple in strategy design, has a potential application prospect in the aspect of preventing blood contact catheter related infection and thrombosis, and has a wide application prospect. The complication occurrence rate and the medical care cost can be reduced.

The invention provides an anticoagulant coating for medical instruments, which can be used in the field of regenerative medical instruments. The prepared anticoagulant coating has short-term and long-term anticoagulant performance, and in addition, the thrombin responsive nanoparticles wrapped in the hydrogel coating can selectively release a factor Xa (FXa) inhibitor apixaban according to needs, so that thrombosis is inhibited in the middle stage of implantation. In-vitro and in-vivo experimental evidences show that after the material is implanted for a long time, an organized endodermis can be seen on the surface of the material, and the material has a special antithrombotic characteristic. The dynamic adjusting system has a multi-layer protection mechanism, and a new thought can be provided for designing the surface of a contact blood material adapting to environmental conditions.

The invention relates to the technical field of coating surface preparation, in particular to an anticoagulant coating based on novel tick-derived anticoagulant protein Qinghaenin and a preparation method of the anticoagulant coating. The functional layer of the anticoagulant coating comprises the following components: anticoagulant protein Qinghaenin or a functional peptide fragment Qinghaenin 167-192 of the anticoagulant protein Qinghaenin, wherein the amino acid sequence of the functional peptide fragment is as shown in SEQ ID NO. 2. The preparation method of the anticoagulant coating comprises the following steps: by using a polydopamine coating as a substrate layer, covalently grafting through an amido bond, immobilizing anticoagulant protein Qinghaenin capable of inhibiting FXII factor activation or a functional peptide fragment Qinghaenin 167-192 thereof on the surface of a medical polymer material, and successfully constructing a novel anticoagulant coating. Compared with an unmodified medical polymer material, the modified coating can significantly enhance the hydrophilic performance of the material and inhibit platelet adhesion and activation, finally effectively prolongs the in-vitro blood coagulation time, and shows excellent anticoagulation performance.

A type of additive based on a fluorinated carbamate prepolymer, a preparation method therefor, and a use thereof in the preparation of a medical fluorinated anticoagulant polyurethane material. The preparation method of the additive comprises: reacting a polyester / polyether diol, a diisocyanate and a fluorinated small-molecule diol, to obtain a carbamate prepolymer having an isocyanate end group, and then capping with a monohydric alcohol having a fluorinated carbon chain, to obtain an additive based on a fluorinated carbamate prepolymer. The additive has a high fluorine content. After being blended with a polyurethane masterbatch, fluorine atoms having low surface energy can be enriched on the surface of the material, and the fluorine atom content on the surface of the material can be as high as 60%. This effectively reduces the adhesion of plasma proteins, cells and platelets on the surface of the material, providing the medical polyurethane material with an excellent anticoagulant effect. In addition, it maintains the excellent mechanical properties of polyurethane, and is thus widely applicable in the preparation of medical fluorinated anticoagulant polyurethane materials.

A nanostructured low-immunogenic biological artificial blood vessel, a preparation method therefor and a use thereof. The preparation method comprises: decellularizing a pre-treated animal blood vessel to obtain a decellularized blood vessel; treating the decellularized blood vessel in an enzyme solution to obtain an enzyme-treated blood vessel, wherein the enzyme solution comprises nuclease and / or a biological enzyme; and using a cross-linking agent to cross-link the enzyme-treated blood vessel to obtain a nanostructured low-immunogenic biological artificial blood vessel, which is used as a blood vessel transplantation material. The artificial blood vessel overcomes the defects of decreased mechanical properties in decellularized biological tissues, in-vivo calcification after long-term use, and the presence of immunogenicity, antigenic components such as vascular wall cells and cell nuclei are fully removed, and original collagen and other extracellular matrix structural proteins in the tissue are retained to a greater extent, avoiding the in-vivo calcification of the blood vessel upon long-term implantation, enhancing the durability of use of the blood vessel; and the method has a short preparation cycle, low cost and high long-term patency rate.

To provide: a method for producing an anti-thrombogenic material in which white turbidity is reduced; a method for producing a medical instrument coated with the anti-thrombogenic material produced by the method; and an anti-thrombogenic material in which white turbidity is reduced.SOLUTION: A method for producing an anti-thrombogenic material according to the present invention comprises a step of copolymerizing a specific alkyl (meth)acrylate, a silicone (meth)acrylate, and an alkoxy polyethylene glycol (meth)acrylate, wherein the silicone (meth)acrylate used here has a weight average molecular weight of 1450 or less.SELECTED DRAWING: None

According to the scheme, the expanded polytetrafluoroethylene artificial blood vessel with the anticoagulant coating and preparation and application are provided, firstly, groups such as carboxyl and amino are formed on the inner surface of the expanded polytetrafluoroethylene artificial blood vessel through co-auto-polymerization reaction of L-dopamine and polyethyleneimine in a Tris aqueous alkali, then epoxy chloropropane serves as a cross-linking agent, and the expanded polytetrafluoroethylene artificial blood vessel with the anticoagulant coating is prepared. Trihydroxymethyl methylamino propanesulfonic acid is cross-linked to the inner surface of the membrane, carboxyl and sulfonic acid groups on the surface of the membrane endow the expanded polytetrafluoroethylene artificial blood vessel with anticoagulation performance, meanwhile, the hydrophobic performance of the outer surface is reserved, anticoagulation finishing is conducted on the inner wall of the expanded polytetrafluoroethylene artificial blood vessel, and the hydrophobic performance of the outer wall of the blood vessel is reserved; the expanded polytetrafluoroethylene artificial blood vessel has an anticoagulation function and does not influence the growth of fiber cells and fiber connective tissues on the surface of the blood vessel.

The invention belongs to the technical field of heparin anticoagulant coatings, and particularly relates to a long-acting heparin anticoagulant coating and a preparation method thereof. The long-acting heparin anticoagulation coating is formed by curing a long-acting heparin anticoagulation coating, and the long-acting heparin anticoagulation coating comprises a component A and a component B; the raw materials of the component A comprise at least one of a monomer, an initiator, a polymer, poly-L-lysine hydrobromide, streptavidin, sodium hyaluronate and crotonaldehyde; wherein the monomer comprises at least one of MPC, PEGMA and SBMA, and the polymer comprises an amino substrate; the raw materials of the component B comprise at least one of a reducing agent and heparin. The preparation method comprises the following steps: circulating the long-acting heparin anticoagulant coating in an ECMO system, and curing to obtain the long-acting heparin anticoagulant coating. The long-acting heparin anticoagulant coating constructed by the invention can realize a lasting and stable anticoagulant effect in an ECMO system, and can overcome the defects in the prior art.

The invention provides a medical stent and a preparation method thereof.The preparation method comprises the steps that an anti-coagulation coating is arranged on at least part of the surface of the medical stent through physical coating, then an anti-hyperplasia coating is arranged on at least part of the surface of the medical stent through physical coating, the anti-coagulation coating comprises a copolymer, and the anti-hyperplasia coating comprises an anti-hyperplasia coating. A copolymer in the anticoagulant coating contains a zwitterionic unit and an adsorption unit, and the anti-hyperplasia coating contains an anti-hyperplasia drug and a degradable polymer; or, an anti-hyperplasia and anti-coagulation integrated coating is arranged on at least part of the surface of the medical stent through physical coating, the integrated coating contains a copolymer and an anti-hyperplasia drug, and the copolymer in the integrated coating contains a zwitter-ion unit, an adsorption unit and a degradable unit; the adsorption unit is an ester unit containing a carbon-carbon double bond, and the degradable unit is a 2-methylene-1, 3-dioxane unit. The problem that thrombus and restenosis exist at the same time after the stent is implanted can be solved, the binding force between the coating and the substrate is improved, and the falling risk of the coating is reduced.

A composition for the surface treatment of a polymer material includes a hyperbranched polyglycerol comprising a glycidol-derived repeating unit and an unsubstituted or substituted acrylate group at least at one end thereof. The composition has the effect of suppressing fibrosis, thrombus formation, or inflammatory cell adsorption by preventing proteins from being adsorbed to the surface of a polymer material that is surface-treated with the composition or an in-vivo implantation material including a polymer material.

The invention discloses a drug-loaded nanogel modified bioprosthetic valve as well as a preparation method and application thereof, and belongs to the technical field of preparation of medical materials and medical instruments. The preparation method comprises the following steps: firstly, synthesizing an active oxygen response monomer by taking thioketal-containing methacrylate and methylprednisone hemisuccinate as raw materials, then synthesizing active oxygen response type drug-loaded nanogel, and then introducing the active oxygen response type drug-loaded nanogel to the surface of the bioprosthetic valve through chemical bonding; in a pathological environment with relatively high active oxygen concentration, a thioketal group in the monomer is decomposed, and methylprednisone hemisuccinate is released at a fixed point, so that inflammatory cell infiltration is reduced, and the anti-inflammatory performance of the bioprosthetic valve is improved; in addition, the nanogel contains a large number of hydrophilic groups, a hydration layer is formed on the surface of the bioprosthetic valve, and the risk of thrombus and blood coagulation can be effectively reduced; the prepared bioprosthetic valve has excellent anti-inflammatory, anti-coagulation and anti-calcification capabilities and stability.

The invention discloses a bioprosthetic valve modifier, a polymer-modified bioprosthetic valve and a preparation method, and belongs to the technical field of preparation of medical materials and medical instruments. The bioprosthetic valve modifier is formed by polymerizing a diclofenac monomer containing a thioketal group, a hydrophilic monomer, a cross-linking agent, an active ester monomer and an initiator. The preparation method of the polymer-modified bioprosthetic valve comprises the following steps: sequentially soaking a bioprosthetic valve material in a glutaraldehyde solution, an amino cationic polymer solution and a nanogel solution, and finally soaking the bioprosthetic valve twice with an active ester compound solution to obtain the polymer-modified bioprosthetic valve. According to the polymer-modified bioprosthetic valve prepared by the invention, the nanogel is modified on the surface of the valve in a covalent bond manner, so that the polymer-modified bioprosthetic valve has good stability and long-term effect, has good biocompatibility and anti-inflammatory, anti-coagulation and anti-calcification effects, and has a good medical application prospect.

The invention discloses a central venous catheter coating formula and a preparation method thereof.The coating comprises a bottom coating and a top coating, the top coating covers the bottom coating, and the bottom coating comprises, by weight, 50-60 parts of a primer, 1.5-2 parts of a cross-linking agent A, 25-30 parts of ethyl alcohol and 25-30 parts of purified water; the formula of the top-layer coating comprises 100-120 parts by weight of a top coating agent, 1-3 parts by weight of a cross-linking agent B and 100-200 parts by weight of purified water, and the formula of the bottom-layer coating and the formula of the top-layer coating are anti-sticking, hydrophilic and lubricating; the bottom coating has the effect of enhancing adhesive force and is firmly bonded with the base material, and the top coating is combined with the bottom coating through temperature crosslinking, has hydrophilic lubrication and anticoagulation functions and is firmly combined with the base material of the central venous catheter to form the coating with good biocompatibility and antithrombotic effect.

The present invention provides a means capable of further improving antithrombogenicity in a medical instrument.　A medical instrument according to the present invention comprises a substrate and an antithrombotic layer having a polymer fixed to the substrate, wherein the polymer has: a first monomer-derived constitutional unit a which is bonded to the substrate and has an ethylenically unsaturated group and a reactive group that reacts with a hydroxyl group or a carboxyl group; a constitutional unit B which has a polymer chain containing a first antithrombotic monomer-derived constitutional unit b having a carboxyl group and an ethylenically unsaturated group, and in which the constitutional unit a and the end of the polymer chain are bonded; and a copolymer-derived constitutional unit C which is bonded to the constitutional unit b and has a second monomer-derived constitutional unit c1 having an amino group and a second antithrombotic monomer-derived constitutional unit c2.

The invention discloses a photocuring hydrogel anticoagulant coating and a preparation method thereof, and belongs to the technical field of biomedicine. The preparation method comprises the following steps: firstly, preparing methacrylated polyvinyl alcohol, methacrylated heparin, a photoinitiator and water into a uniform coating dipping solution, dipping a substrate with a clean surface into the coating dipping solution for 5-100 minutes, taking out the substrate, airing, repeatedly dipping for 2-10 times, and curing the obtained substrate under ultraviolet excitation light to obtain the coating. The preparation process of the photocuring hydrogel anticoagulant coating is simple and easy to operate, the reaction condition is mild, and the prepared photocuring hydrogel anticoagulant coating has very good biocompatibility, can be firmly combined with a substrate material, has very excellent anticoagulant performance and has very good application prospects.

The invention discloses a double-layer small-caliber artificial blood vessel with an in-situ modified anticoagulant coating and a preparation method. The double-layer small-caliber artificial blood vessel with the in-situ modified anticoagulant coating is prepared by combining a coaxial dry-jet wet spinning technology and a polydopamine-heparin modification technology. According to the obtained double-layer small-caliber blood vessel, the outer layer provides enough mechanical strength and structural stability, the inner layer has good hydrophilicity and excellent anticoagulation function through polydopamine in-situ grafting heparin, activation of platelets and adhesion of blood cells are reduced, formation of short-term acute thrombus is prevented, and the endothelialization process of the small-caliber blood vessel is promoted; according to the method provided by the invention, the manufacturing and surface modification process of the small-caliber artificial blood vessel is simplified, additional procedures such as secondary processing are avoided, the modification position and the grafting amount are controllable, the experimental stability is high, and a convenient and efficient preparation technical idea is provided for developing the small-caliber artificial blood vessel.

The construction method comprises the following steps: performing decellularization treatment on a pig heart aorta blood vessel, compounding the treated pig heart aorta blood vessel with polyvinyl alcohol and methacryloylated gelatin to prepare a pre-gel solution, printing a designed model into a hollow tubular mold by using white resin through 3D printing, and preparing the hollow tubular mold into the artificial blood vessel stent with the anticoagulation performance. Injecting the pre-gel solution into a mold for cross-linking to obtain an artificial blood vessel stent with controllable shape and size, and finally loading an anticoagulant drug heparin on the prepared stent to obtain the heparin-loaded artificial blood vessel stent. Materials for preparing the pre-gel solution are selected, and advantage complementation of material functions can be achieved. The acellular matrix is beneficial to adhesion, proliferation and differentiation of cells; the composite polyvinyl alcohol and methacrylated gelatin improve the mechanical properties of the scaffold and improve the cell adhesion. Heparin is loaded on the artificial blood vessel stent to improve the anticoagulation performance of the stent and prevent thrombus. As an excellent biomedical material, the stent has a wide application prospect in the related fields of cardiovascular tissue engineering and biology.

The invention discloses a synergistic dual-mode anticoagulation and anti-inflammatory central venous catheter BC-BCD double-layer bionic hydrogel coating and a preparation method thereof. BSA / CBAA hydrogel formed by copolymerizing bovine serum albumin and carboxyl betaine acrylamide is used as an outer coating of the catheter, dopamine containing catechol groups is introduced as a main chain network, and BSA / CBAA / DA hydrogel is obtained and used as an inner coating of the catheter. The two layers are combined through a two-step impregnation method to obtain the BC-BCD double-layer bionic coating, thrombus can be defended on a catheter interface in an active mode and a passive mode, oxidation factors in a body can be removed, oxidative stress and bacterial infection can be reduced, and the BC-BCD double-layer bionic coating can be tightly attached to a base material. Experimental results show that the prepared bionic hydrogel coating has excellent anticoagulation and anti-inflammatory performance and long-term stable adhesion performance, the main defects of a traditional central venous catheter are remarkably overcome, and the bionic hydrogel coating has a positive effect on clinical prevention of thrombus and infection.

The present invention relates to the field of blood-contacting medical device coatings, and in particular, to an amino-containing polymer, and a preparation method therefor and the use thereof. The amino-containing polymer is an amino-containing ternary random polymer. The structural formula of the amino-containing polymer is (I), wherein the ratio of m / n / k is 7:1:2; a is 2, 4 or 5, and b is 3, 4 or 5. The weight average molecular weight of the amino-containing polymer is 4000-9000 Da. The polymer has good reaction activity, platelet adhesion resistance, platelet activation resistance and fibrinogen adhesion resistance at the same time, and can be chemically fixed on the surface of a medical device efficiently, to exert an anticoagulant advantage.

The invention belongs to the technical field of biomedical materials, and particularly relates to a poly-4-methyl-1-pentene (PMP) gas-blood exchange membrane for an extracorporeal membrane oxygenation (ECMO) system, which realizes a long-acting antithrombotic function through a bionic interface construction technology. The invention aims to provide a bionic antithrombotic PMP gas-blood exchange membrane based on zwitter-ion gradient grafting, and through material and process innovation, the following problems existing in a traditional ECMO gas-blood exchange membrane: an antithrombotic coating is easy to fall off, and the long-term effect is insufficient; the risk of blood injury caused by dependence on heparin or anticoagulants; and the surface modification process destroys the membrane pore structure and air permeability.

The invention relates to an anticoagulant medical device and a preparation method thereof. The preparation method of the anticoagulant medical device comprises the following steps: covalently connecting the hydrophilic anticoagulant layer on the surface of the base material in an atom transfer radical polymerization manner; a heparin anticoagulation layer is covalently connected to the surface of a hydrophilic anticoagulation layer to prepare the anticoagulation medical device, and the heparin anticoagulation layer and the hydrophilic anticoagulation layer are connected through one or more covalent bonds of a triazole bond, an amido bond, a carbon-nitrogen single bond and a carbon-sulfur single bond. According to the preparation method of the anticoagulation medical device, the anti-protein adsorption effect of the hydrophilic anticoagulation layer and the anticoagulation effect of the heparin anticoagulation layer can be synergistically exerted, the anticoagulation effect is improved, and meanwhile, the anticoagulation stability is improved.

The invention relates to the technical field of biological materials, in particular to a local anticoagulation acellular bone matrix composite material and a preparation method thereof.The preparation method comprises the following steps that S1, bone tissue is obtained and treated, and an acellular bone matrix is prepared; s2, mixing an anticoagulant with the acellular bone matrix to form an anticoagulant compound; s3, mixing the anticoagulant compound with a biocompatible carrier to form a final composite material; and S4, preparing the composite material into an implant or a stent with a required shape through a molding and curing process. By arranging the acellular bone matrix, the natural structure and biological activity of the bone matrix are reserved to the maximum extent, and meanwhile, all cell components are removed, so that immunogenicity and pathogen transmission are reduced; by adding the anticoagulant, discomfort can be reduced after the local anticoagulant acellular bone matrix composite material is implanted into a human body, and the problems that in the prior art, an acellular bone matrix has the blood coagulation risk, and incompletely-treated bone tissue has immunological rejection are solved.

The invention relates to the field of medical instruments, in particular to a composite heparin anticoagulant coating and a preparation method thereof. The method comprises the following steps: ultraviolet light pretreatment: carrying out ultraviolet light pretreatment on a substrate material to initiate polyethyleneimine to be grafted on the surface of the material; turning coating: coating the surface of the substrate material with a heparin solution, and fixing with an EDC solution; and the coating direction is changed in the coating process. Amino chains are introduced to the surface of a substrate material through ultraviolet light, the surface is provided with positive charges, and the heparin coating is formed through ionic bond combination. After the coating is completed, the coating is fixed by using an EDC solution, and the coating direction is changed in the coating process, so that the stability, the uniformity, the hydrophilicity and the anticoagulation performance of the coating are improved.

The invention relates to a nutritional composition comprising a combination of (i) omega-3 fatty acid DHA with (ii) vitamin B2 and (iii) vitamin D3 and one or more from (iv) choline or a salt thereof and / or choline esters; and (v) dietary fibres and / or dietary butyrate for use in the treatment of neurodegenerative diseases and / or neurotrauma, brain injury and / or brain damage. The invention also relates to a composition comprising a combination of DHA, vitamin B2, vitamin D3 with one or more from (iv) choline or a salt thereof and / or choline esters; and (v) dietary fibres and / or dietary butyrate.

High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces. Polymers may be entrapped in pores of materials to provide a durable modification of the materials.

A medical device is provided, comprising: an expandable tubular member comprising a plurality of elements forming a sidewall, wherein each of the elements crosses one or more other elements and a plurality of pores are formed among the elements in the sidewall; wherein an antithrombogenic material is coated over the tubular member such that there is inherently no webbing of the antithrombogenic material between any two elements.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The present invention addresses the problem of providing a carrier for easily introducing a medicine or the like into cells.　It was found that the problem can be solved by: a collagen-binding membrane-permeable peptide comprising a collagen-binding domain, a membrane fusion domain, and a membrane-permeable domain; and a carrier comprising said peptide and collagen or a collagen derivative. Due to the foregoing, the present disclosure was completed.

Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.