635 results about "Protection sex" patented technology

Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures, such as impinged lateral recesses and pathologically narrowed neural foramen. In one variation, tissue may be ablated, resected, removed, or otherwise remodeled by standard small endoscopic tools delivered into the epidural space through an epidural needle. Once the sharp tip of the needle is in the epidural space, it is converted to a blunt tipped instrument for further safe advancement. A specially designed epidural catheter that is used to cover the previously sharp needle tip may also contain a fiberoptic cable. Further embodiments of the current invention include a double barreled epidural needle or other means for placement of a working channel for the placement of tools within the epidural space, beside the epidural instrument. The current invention includes specific tools that enable safe tissue modification in the epidural space, including a barrier that separates the area where tissue modification will take place from adjacent vulnerable neural and vascular structures. In one variation, a tissue removal device is provided including a thin belt or ribbon with an abrasive cutting surface. The device may be placed through the neural foramina of the spine and around the anterior border of a facet joint. Once properly positioned, a medical practitioner may enlarge the lateral recess and neural foramina via frictional abrasion, i.e., by sliding the tissue removal surface of the ribbon across impinging tissues. A nerve stimulator optionally may be provided to reduce a risk of inadvertent neural abrasion. Additionally, safe epidural placement of the working barrier and epidural tissue modification tools may be further improved with the use of electrical nerve stimulation capabilities within the invention that, when combined with neural stimulation monitors, provide neural localization capabilities to the surgeon. The device optionally may be placed within a protective sheath that exposes the abrasive surface of the ribbon only in the area where tissue removal is desired. Furthermore, an endoscope may be incorporated into the device in order to monitor safe tissue removal. Finally, tissue remodeling within the epidural space may be ensured through the placement of compression dressings against remodeled tissue surfaces, or through the placement of tissue retention straps, belts or cables that are wrapped around and pull under tension aspects of the impinging soft tissue and bone in the posterior spinal canal.

A protective sports helmet that is molded from a shock absorbing foam. The helmet is preferably an single, homogenous piece of injection molded foam. An insert plate can be positioned near the user's forehead at the top and forward portion of the helmet. The purpose of the insert plate is to simulate the hardness of the user's head for heading a ball. The helmet can head the ball without the injury to the head and the brain as potentially encountered without protection. The soft-shell also minimizes injuries on other parts of the body that are struck by the helmet. The helmet can be utilized for football and other contact sports. Additional external components such as metal or plastic inserts can be inset molded into the foam. The purpose of these inserts is to improve stability and allow for attachment of face guards and chin straps.

The present invention provides articles of footwear adapted for use in extreme and hazardous environments by members of the military, law enforcement personnel and others who require durable and functional footwear. The footwear include protective coverings that may be proof, puncture proof, fire retardant or water repelling. Drainage holes can be positioned in the toe region and along the outsole to enable a wearer to quickly drain water from the article of footwear. Single use or replaceable drainage plugs may cover the holes to prevent entry of water into the boot or other article of footwear. Removable and / or replaceable footbeds may be employed, and such footbeds may provide adjustable sizing of the article of footwear using interchangeable cartridges. A support saddle may be employed with the footbed to enhance foot support under heavy loads. These and other features herein are suited for use in a wide variety of footwear.

Aspects of the invention include a sleeve or wrap for protecting a container. In certain embodiments, the sleeve or wrap is a protective encasement for protecting a container, such as a bottle. In certain embodiments, the sleeve or wrap includes a body with a lumen, wherein the body is configured for holding and / or containing the container. For instance, in one embodiment, the protective sleeve includes a tubular body and at least a first opening in the protective body that is adapted for receiving the container. In certain embodiments, the body of the sleeve includes silicone. Accordingly, in certain embodiments, the sleeve is a protective silicone sleeve that is adapted to hold and / or contain a container, thereby protecting the container from damage (e.g., breaking). Also provided is a system for protecting a container that includes a protective sleeve, as described above, and a container that is configured for being associated, e.g., fit within, the protective sleeve.

Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.

The present invention is directed to a protective sports helmet comprising a helmet shell, a face guard and an internal padding assembly positioned within the helmet shell. The internal padding assembly includes a brow pad having first and second peripheral connection portions. The internal padding assembly also includes first and second jaw pads, each having an upper connection portion that mates with the first and second connection portions, respectively, of the brow pad. The internal padding assembly also includes a crown assembly with pad elements that include an internal separation layer that partitions the element into a first inflatable section and a section un-inflatable section. The connection portion of the jaw pads also mates with frontal pad elements of the crown assembly. The internal padding assembly further includes an occipital pad assembly that engages the helmet wearer's head below the occipital bone.

The present invention relates generally to methods of treating or preventing RSV infections, and more specifically, to compositions, and the use thereof, comprising one or more RSV G protein immunogen or fragment thereof capable of eliciting protective immunity without eliciting an immunopathological response or eliciting a reduced immunopathological response.

The present invention comprises compositions, methods and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.

The present invention discloses various features and combinations thereof for use with articles of footwear such as boots. The boots are especially adapted for use on construction projects, and provide protection, support and comfort to the wearer. Numerous outsole configurations and styles are provided, which provide superior traction and a low center of gravity for enhanced balance. Different layers of materials provide puncture resistance, abrasion resistance, thermal insulation, waterproofing and other benefits. Protective and / or insulative plates may be utilized in the footwear for puncture protection or thermal insulation, for example. Shovel guards protect the wearer when using a tool, and toe tools permit the wearer to employ the boot as a tool of its own. Structural support cages chimney structures are also utilized for support and comfort.

A reflecting element with multiple reflective facets is integrated with the distal end of a multi-fiber optical probe. The facets are shaped depending on the type of analysis performed and according to the desired distribution of radiation to and from internal body tissues and fluids. The probe can include a protective transparent balloon or other covering that separates the reflecting element from interior tissue walls and provides a window for radiation to be transmitted between the reflecting facets and a region of interest. The probe can be integrated with treatment-based devices, including lumen-expanding angioplasty balloon catheters. The probe can also be adapted as an imaging device such as an endoscope.

Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

A helmet construction for protecting a user's head, and the brain within the cranium from impact forces, includes a shell contoured to the shape of the user's head, with cushioning along at least part of the shell interior and a chinstrap. The shell consists of three (or more) discrete panels that are physically and firmly coupled together providing rigid protection under most circumstances, but upon impact the panels move relative to one another, but not relative to the user's head, thereby permitting impact forces to be dissipated and / or redirected away from the cranium and brain within. Upon impact to the helmet, there are sequential stages of movement of the panels relative to each other, these movements initially being recoverable, but with sufficient vector forces the helmet undergoes structural changes in a pre-determined fashion, so that the recoverable and permanent movements cumulatively provide a protective ‘crumple zone’ or ‘shear zone’. The first two stages of protection arise from the design of the fasteners that have the ability to invaginate and collapse within themselves, and their design having a 45 degree angle, which will allow movement of a region of connected panels to translate along the fastener shaft. Both of these movements will be recoverable and provide a ‘functional crumple zone’. The final stage of protection arises from the braking function of the pins, as they are forced from one aperture through to the next, the direction and extent of which is determined by the impact force and direction. This final level of panel movement and protection is not recoverable and thus provides a ‘structural crumple zone’. Finally the fastener size and thickness, together with the thickness of webbing and distance between apertures, functions to provide varying degrees of resistance to impact forces, thus making the helmet design suitable for activities with different levels of impact speed and risk potential.

The present invention provides for selective and uniform delivery of compositions to protect certain targeted areas: (1) skin proximate colorable or dyeable hair from staining by hair colors or hair dyes; or (2) skin proximate nails against nail skin contaminants which may include hair color or hair dyes. Embodiments of products of the present invention may comprise the protective composition and a device for selective and uniform delivery of the composition to the targeted area of the skin. Products may also comprise a protective composition having a solid or semisolid consistency which is formed to enable selective and uniform delivery of the composition to the targeted area of the skin. Products may also comprise: (a) a hair color or hair dyeing kit comprising the protective composition and one or more hair color or hair dyeing components; or (b) a nail cosmetic kit comprising the protective composition and one or more nail cosmetic components.

A system of manufacturing to incorporate protective materials with high cut and puncture resistance into standard safety and apparel products including gloves, to create a highly effective and low cost system of producing safety garments while preserving the characteristics of the original garment. This includes attaching a cut and puncture resistant protective liner or multiple liners to the inside or outside of or within a garment such as a glove by means of adhesives or stitching. The liner may be a protective liner with cut resistance greater than 450 lbs per inch / thickness and / or puncture resistance greater than 50 lbs per inch / thickness depending on the application requirement for protection and dexterity.

Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.

A helmet construction for protecting a user's head, and the brain within the cranium from impact forces, includes a shell contoured to the shape of the user's head, with cushioning along at least part of the shell interior and a chinstrap. The shell consists of three (or more) discrete panels that are physically and firmly coupled together providing rigid protection under most circumstances, but upon impact the panels move relative to one another, but not relative to the user's head, thereby permitting impact forces to be dissipated and / or redirected away from the cranium and brain within. Upon impact to the helmet, there are sequential stages of movement of the panels relative to each other, these movements initially being recoverable, but with sufficient vector forces the helmet undergoes structural changes in a pre-determined fashion, so that the recoverable and permanent movements cumulatively provide a protective ‘crumple zone’ or ‘shear zone’. The first two stages of protection arise from the design of the fasteners that have the ability to invaginate and collapse within themselves, and their design having a 45 degree angle, which will allow movement of a region of connected panels to translate along the fastener shaft. Both of these movements will be recoverable and provide a ‘functional crumple zone’. The final stage of protection arises from the braking function of the pins, as they are forced from one aperture through to the next, the direction and extent of which is determined by the impact force and direction. This final level of panel movement and protection is not recoverable and thus provides a ‘structural crumple zone’. Finally the fastener size and thickness, together with the thickness of webbing and distance between apertures, functions to provide varying degrees of resistance to impact forces, thus making the helmet design suitable for activities with different levels of impact speed and risk potential.

The invention relates to peptide, oligopeptide or polypeptide compounds that are capable of eliciting a protective immune response against the capsular polysaccharide of group B Streptococcus (GBS), particularly type III GBS. Such compounds are useful in the development of vaccines that are effective against diseases caused by these pathogens.

This invention relates to in-situ preparation, and stable topical delivery systems of ascorbic acid salts of organic bases that provide skin beneficial properties, including reduction in signs of skin aging, anti-wrinkle, anti-oxidant, and photo-protection from UV and sunlight. The formulation avoids the use of oils, minimizes the importance of the pH of the formulation, allows the incorporation of an aqueous solution of ascorbic acid or alkali metal salts of ascorbic acid in the formulation, does not require packaging the formulation in air tight containers, allows the use of large amounts of ascorbic acid, its salts, and its derivatives, and does not require the use of expensive coatings. Moreover, several ascorbic acid derivatives of different chemical composition can be made in a stable topical formulation by the in-situ combination of readily available starting materials in a water solution, despite the understanding well known in the prior art that such compositions in water are inherently unstable. The in-situ method also permits the preparation of novel ascorbic acid derivatives that are not known in the prior art.

Antimicrobial fabrics having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The antimicrobial fabric may be formed into a garment to be worn as a base layer garment, close to the skin, which aids in the prevention of skin infection caused by abrasions to the skin. The garment may also aid in preventing the transfer of microbes from one person to another, for instance, after sharing communal items such as protective athletic equipment. The antimicrobial fabric exhibits long lasting antimicrobial efficacy against both Gram positive and Gram negative microbes and also exhibits antimicrobial efficacy after repeated wash cycles. Also provided is a method for making the silver-containing antimicrobial fabric.

An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.

Compounds and methods for inducing protective immunity against cancer are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more SPAS-1 proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and pharmaceutical compositions for immunization against cancer, or can be used for the diagnosis of cancer and the monitoring of cancer progression

The present application is directed to therapeutic compounds, compositions, and methods for culturing neuronal cells and for preventing and the treatment of neurodegenerative diseases, such as Parkinson's disease and amyotrophic lateral sclerosis (ALS).

An immunization strategy to provide protection against disease caused by infection with a paramyxoviridae virus, specifically respiratory syncytial virus (RSV) and parainfluenza virus, is described. A priming intranasal administration of a recombinant virus expressing at least one RSV or PIV protein or immunogenic sequence there first is made to the host followed by a booster administration of at least one purified RSV or PIV protein or immunogenic fragment thereof, which may be adjuvanted with alum. This immunization strategy provides a safe and effective means of controlling RSV and PIV infections. The strategy leads to a stronger protective immune response than other strategies and to the induction of a more balanced Th-1 / Th-2 type response than previously attained. Novel recombinant poxviruses are provided containing nucleic acid encoding a paramyxovirus protein or immunogenic fragment thereof is a non-essential region of the poxvirus genome, specifically NYVAC-F and ALVAC-F, which produce the F glycoprotein of RSV.