298 results about "Tissue surface" patented technology

Apparatus comprising a housing, at least one needle arranged for reciprocal motion between a retracted position and an extended position to penetrate an animal tissue surface when in the extended position, and a sealing device defining a channel through which a movable shaft extends to move the at least one needle in the reciprocating motion, wherein the sealing device serves to form a seal between the housing and the movable shaft. A corresponding method of preventing cross-contamination within apparatus for minimally invasive treatment of skin is also disclosed.

The invention provides a radio frequency therapeutic instrument control method, and relates to the technical field of medical instruments, and the method comprises the steps: obtaining the dynamic change information of a target tissue surface temperature field in real time through collecting the dynamic temperature data of a target tissue surface; setting a temperature control constraint of the radio frequency therapeutic apparatus according to a plurality of temperature deviation indexes corresponding to the temperature sudden change area; performing region communication on the heat distribution rule in the temperature mutation region to obtain a temperature compensation boundary corresponding to the temperature mutation region on the surface of the target tissue, and determining a temperature change compensation trend of the radio frequency therapeutic apparatus according to the temperature compensation boundary and the dynamic temperature data; and determining multi-stage radio frequency treatment signals of the radio frequency treatment instrument in different temperature fields according to the temperature control constraint and the temperature change compensation trend, and matching temperature control strategies of the radio frequency treatment instrument according to the multi-stage radio frequency treatment signals. According to the invention, intelligent matching of temperature control strategies can be realized through multi-stage radio frequency treatment signals, so that the stability of temperature control of the radio frequency therapeutic apparatus is improved.

According to the flexible array type external field program control nerve stimulation device, the preparation method and the application thereof, the flexible array type external field program control nerve stimulation device comprises a flexible substrate layer and a stimulation response fiber array layer, and the stimulation response fiber array layer is prepared from a functional material capable of converting external field energy such as ultrasound, magnetism and light into electric energy; the flexible substrate layer with high flexibility is adopted, so that the flexible substrate layer can be matched with the surface of a nerve target tissue in a conformal manner; the stimulation response fiber array layer integrated on the flexible substrate layer in an array arrangement mode can meet the stimulation spatial resolution of neuron and even sub-neuron precision, has the characteristics of excellent flexibility, biocompatibility, passivity and wireless performance, can provide nerve electrical stimulation signals with high spatial resolution, and can be applied to the field of nerve electrical stimulation. The high-resolution nerve electrical stimulation device can be in conformal fit with the irregular surface of nerve soft tissue, and is suitable for high-resolution nerve electrical stimulation of different parts such as eyes, the brain and peripheral nerves.

An anvil buttress loading system includes an anvil assembly having a snap clip disposed on a tissue facing surface, a loading tool including a clip roller extending proximally from a support plate, and an anvil buttress including a buttress body. The snap clip is movable between closed and open positions having generally concave and convex shapes, respectively, relative to the tissue facing surface. The anvil buttress is releasably retained on the loading tool and is transferrable from the loading tool to the anvil assembly such that the buttress body is captured between the snap clip and the tissue facing surface of the anvil assembly. The snap clip is movable from the closed position to the open position by the clip roller when advancing the loading tool onto the anvil assembly and from the open position to the closed position when separating the loading tool from the anvil assembly.

The invention provides efficient gelatin hemostatic microspheres as well as a preparation method and application thereof, the preparation method comprises the following steps: mixing a gelatin solution with a tannic acid solution, and uniformly stirring to obtain a tannic acid modified gelatin aqueous solution; uniformly mixing span-80 with liquid paraffin to obtain an oil phase; adding the tannic acid modified gelatin aqueous solution into an oil phase, and uniformly stirring to obtain a mixed solution; the mixed solution is subjected to a cross-linking reaction under the ice bath condition, after the cross-linking reaction is completed, a reaction solution and acetone are mixed, liquid paraffin is removed after standing, and the tannic acid modified hemostatic microspheres are obtained after drying; mixing the tannic acid modified hemostatic microspheres with an adsorbent, and dehydrating to obtain the gelatin hemostatic microspheres. The prepared gelatin hemostatic microspheres can be attached to the surface of tissue and have the effects of high water absorption and rapid hemostasis.

The invention belongs to the technical field of biological materials and ultrasonic printing, and particularly discloses a biological adhesive for ultrasonic printing and preparation and application thereof. The biological adhesive comprises a heat-sensitive main body material and a chemical adhesion component, the heat-sensitive main body material comprises hydroxybutyl chitosan, and the chemical adhesion component comprises polyacrylic acid-N-hydroxysuccinimide ester. The bioadhesive has excellent ultrasonic responsiveness, formability and bioadhesion performance, directional deposition, in-situ solidification and tissue surface adhesion can be achieved in a non-contact and accurately-controlled ultrasonic printing system, and the bioadhesive is suitable for various biomedical scenes such as tissue repair, minimally invasive medicine, biological device construction and drug delivery interface printing.

The invention relates to the technical field of medical image processing, in particular to a gynecological endoscope image intelligent analysis and cervical lesion precise diagnosis system. Comprising an image enhancement module, a differential geometric feature extraction module, a topology preserving manifold learning module, a curvature-blood vessel correlation analysis module, a biopsy point accurate positioning module, a real-time intelligent auxiliary diagnosis module, a clinical feedback module and a self-adaptive optimization module. Micro morphological change features are extracted through multi-scale curvature analysis; a topology sensitive encoder and a manifold alignment decoder are adopted, and a key topology structure is kept; establishing a correlation model of the tissue surface curvature change and the blood vessel morphology, and analyzing differential morphological characteristics; determining an optimal biopsy position based on the comprehensive characteristics; according to the method, the diagnosis result and basis are generated, visual display is provided, the detection rate of cervical lesions, especially early minimal lesions, is remarkably increased, the missed diagnosis rate is reduced, and multi-point biopsy is reduced.

The invention provides a sampler and a sampling method for collecting biological molecules on the surface of tissue, the sampler is provided with a sampling direction, the sampler comprises a main body, the main body is provided with an arc-shaped track, the center of the arc-shaped track corresponds to the center of the main body, and the sampling direction of the main body is equal to that of the arc-shaped track in one length direction of the track. And the radius of the arc-shaped track is gradually increased or decreased. According to the sampler for collecting the biological molecules on the surface of the tissue, a plurality of sampling needles are arranged, a sampling liquid drop corresponding to a sampling center can be formed and maintained among the output ends of the plurality of sampling needles, and a non-embedded sampling mode is realized through contact between the liquid drop and the surface of the biological tissue; the damage to the integrity of key biomolecules possibly caused by a traditional method is avoided, the acquisition of high-fidelity biomolecules is facilitated, and the sampler can reduce physical disturbance and mechanical damage to fragile tissues to the maximum extent.

The invention belongs to the technical field of medical robots and minimally invasive surgery, and provides a robot control system and method for blue laser vaporization surgery of prostatic hyperplasia. Mapping the nuclear magnetic image volume data to a deformation field under an ultrasonic acquisition coordinate system, and deforming the preoperative nuclear magnetic image to an intra-operative ultrasonic space by using the deformation field to complete image registration; fusing the registered image with a stereoscopic vision system; the spatial depth of the surface of the target tissue is obtained from the endoscopic image so as to supplement navigation information; according to the utility model, the prostate deformation and probe posture change adaptive capacity in an operation is improved, the real-time visual closed-loop regulation and control capacity is improved, and the characteristics of small light spots, shallow heat diffusion, excellent hemostasis and the like of blue laser are combined, so that the vaporization and hemostasis precision in a tiny blood vessel dense area is ensured, and the problems of large tissue trauma and the like are avoided.

The invention relates to the technical field of planting bridges, and particularly discloses a hollow planting bridge and a preparation method thereof. The preparation method comprises the following steps: acquiring an initial model; the initial model is imported into MaterialiseMagics software, and an internal hollow structure is designed; preparing a planting bridge frame by using an additive manufacturing technology; the free ends of the lingual side, the palatal side or the two sides of the planting bridge are provided with slag discharging openings, and the slag discharging openings are far away from the screw channels, the edge lines and the tissue surfaces; and after the internal supporting material is removed, the slag discharging opening is sealed through resin. The hollow planting bridge frame comprises a planting bridge frame; a hollow structure; the connecting base is in the form of a preparation body or a complete tooth; the number of the screw channels is matched with that of the implants; the number of the implant abutment interfaces is matched with that of the implants; and the residue discharging openings are formed in the free ends of the tongue side, the palate side or the two sides of the planting bridge frame, and the residue discharging openings are sealed by resin. Therefore, the problems that in the prior art, a bridge frame is heavy, and the burden on an implant is large are solved.

The invention provides an anastomotic stoma reinforcing device as well as a preparation method and application thereof. The anastomotic stoma reinforcing device comprises a reinforcing material layer, a connecting material layer and a release film which are sequentially stacked, wherein the connecting material layer comprises a hydrophobic adhesive layer, a carrier layer and a waterproof adhesive layer which are sequentially stacked, and the hydrophobic adhesive layer is in contact with the reinforcing material layer. When the anastomotic stoma reinforcing device is used, the release film of the anastomotic stoma reinforcing device is peeled off, the reinforcing material layer can be fixed to the nail bin face and / or the nail anvil face of an anastomat by means of the waterproof glue layer, due to the fact that the reinforcing material layer has hygroscopicity and can be completely wetted after making contact with liquid on the tissue surface, the reinforcing material layer and the hydrophobic glue layer are separated, and therefore the anastomotic stoma is reinforced. However, the material of the anastomat does not absorb moisture, the connecting material layer is still firmly adhered to the anastomat and is not easy to separate, and when the anastomat is taken out, the connecting material layer is taken out along with the anastomat, so that the problems of slow postoperative recovery and the like caused by connecting material residues are avoided.

The invention discloses a Transform-based wet tissue surface defect real-time detection method. The method comprises the following steps: acquiring category information and a detection image of a to-be-detected wet tissue; the detection image comprises a visible light image and a near-infrared image; according to the category information of the to-be-detected wet tissue, acquiring category features through a preset category feature information base, and encoding the category features to generate category feature vectors; performing feature extraction on the visible light image and the near-infrared image to obtain visible light features and near-infrared features; based on the category feature vector, dynamically fusing the visible light feature and the near-infrared feature through a cross attention mechanism to generate a fused feature; and based on the fusion features, generating a wet tissue surface defect detection result through a preset defect detection model. According to the method, the accuracy and efficiency of detecting the surface defects of different types of wet tissues can be effectively improved by combining the category feature prior with the visible light feature and near-infrared feature fusion method.

Systems and methods are provided for performing optical coherence tomography (OCT) angiography for the rapid generation of en-face images. According to one example embodiment, differential interferograms obtained using a spectral domain or swept source OCT system are convolved with a Gabor filter, where the Gabor filter is computed according to an estimated surface depth of the tissue surface. The Gabor-convolved differential interferogram is processed to produce an en-face image, without requiring the performing of a fast Fourier transform and k-space resampling. In another example embodiment, two interferograms are separately convolved with a Gabor filter, and the amplitudes of the Gabor-convolved interferograms are subtracted to generate a differential Gabor-convolved interferogram amplitude frame, which is further processed to generate an en-face image without performing a fast Fourier transform and k-space resampling. The example OCTA methods disclosed herein are shown to achieve faster data processing speeds compared to conventional OCTA algorithms.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

The invention discloses a preparation method and application of collagen derivative and polysaccharide substance compounded self-gel hemostatic powder, and relates to the field of biomedical materials. Aminated collagen derivatives and aldehyde polysaccharide substances are subjected to a Schiff base reaction through amino groups and aldehyde groups; further obtaining the Schiff base cross-linked aminated collagen derivative-aldehyde polysaccharide hydrogel, freeze-drying, and grinding into powder, so as to obtain the self-gel hemostatic powder. The self-gel hemostatic powder disclosed by the invention forms hydrogel in a wound tissue for adhesion and sealing, so that rapid hemostasis is realized, postoperative adhesion at the wound tissue is avoided, and healing of a wound is facilitated; after hemostasis is completed, the self-gel powder can be dissociated and removed from the tissue surface, and the risk that thrombus is formed and immunological rejection is caused is reduced; after hemostasis is completed, the hemostasis powder can be metabolized and absorbed by a human body along with thrombus, so that the residue of the hemostasis powder in the body is reduced, and the safety is improved.

The invention discloses a preparation method and application of two chemical crosslinking type injectable hemostatic sealant. According to the invention, four-arm polyethylene glycol succinimide glutaric acid ester (TPEG-SG) and carboxymethyl chitosan (CMCS) are taken as main materials, and calcium chloride is added or not added, so that two injectable hemostatic sealing adhesives with chemical crosslinking characteristics are designed and prepared. After the two kinds of sealant are injected to a bleeding part, rapid and efficient gelation and tissue adhesion can be achieved through chemical crosslinking of carboxyl activating groups of the four-arm polyethylene glycol succinimide glutaric acid ester, amino groups in carboxymethyl chitosan and amino groups on the surface of tissue, and therefore wounds are effectively sealed. Compared with a traditional hemostatic material, the two sealing glues have the characteristics of rapid in-situ wound formation, strong tissue adhesion, rapid hemostasis and the like, the problems of poor adhesion performance and poor hemostasis capability of a conventional hemostatic material are solved, and the hemostatic material is more suitable for hemostasis of non-compressible hemorrhage in a special wound environment and has good clinical and military application prospects.

The invention discloses a medical pressure-sensitive adhesive patch based on citric acid, a preparation method and application, the medical pressure-sensitive adhesive patch is composed of an adhesion layer and an anti-adhesion layer, and the thickness ratio of the adhesion layer to the anti-adhesion layer is 1: 1-100: 1; the adhesion layer is obtained by polymerizing a citric acid unit and a polyhydroxy compound unit; the hydrophobic high-molecular polymer is selected from at least one of a polylactic acid-glycolic acid copolymer, polylactic acid, polyurethane and polyether urethane. According to the preparation method, three carboxyl groups in the citric acid not only can be used for esterification reaction with polyhydric alcohols to form a network, but also can provide excellent adhesive force for contact between the adhesive patch and the tissue surface through electrostatic interaction or hydrogen-bond interaction. The anti-sticking layer prepared from the hydrophobic high-molecular polymer can effectively resist invasion of external moisture and bacteria, so that the service time of the adhesive patch is prolonged; meanwhile, the anti-sticking layer can also play a supporting role, so that the mechanical strength of the adhesive tape is improved.

The utility model discloses an indocyanine green precise puncture and injection device under a laparoscope, which belongs to the field of medical instruments and comprises a needle tube outer cylinder, a middle propelling device arranged in the needle tube outer cylinder, an internal propelling device arranged in the middle propelling device, a negative pressure drainage piece arranged at the head of the needle tube outer cylinder, and a negative pressure drainage piece arranged at the tail of the needle tube outer cylinder. An outer hose is arranged at the other end of the negative pressure drainage piece, a suction cup head is arranged at the other end of the outer hose, an inner hose is arranged at the head of the middle propelling device, the inner hose penetrates through the negative pressure drainage piece and then extends into the outer hose, an injection needle is arranged at the head of the inner hose, and an electrocoagulation wire is arranged in the suction cup head and connected with the injection needle. According to the utility model, an operator can accurately complete puncture and injection operations under a laparoscope; the problem that when indocyanine green is injected, a needle is withdrawn and after the needle is withdrawn, the medicament overflows to pollute the tissue surface is solved; electric coagulation hemostasis can be implemented in the whole operation process; and the medicine injection dosage can be controlled more accurately.

Systems and methods are provided for 3D in vivo ultrasound imaging of a tissue surface, such as a tissue surface located within a joint capsule, during an arthroscopic procedure. An in vivo ultrasound probe is provided having a rotatable distal region supporting an array of ultrasound transducers. An ultrasound array is controlled to collect image data at several elevations while rotating the distal region of the probe to acquire a local 3D image data set across a local 3D volume associated with a current probe pose. This process is repeated as the probe pose changes, resulting in a set of local 3D image datasets, each local 3D image dataset corresponding to a different probe pose. The local 3D image dataset is processed to segment a tissue surface profile and generate a corresponding set of surface tiles. The surface tiles are processed and combined to generate a synthetic 3D image, optionally based on input from one or more sensors.

The LNTPI is a surgical instrument used to cut through fibrotic and edematous tissue to define the natural tissue plane of dissection. After defining the natural tissue plane, it is designed to move or carefully insinuate tissues along these natural planes without cutting the tissue, so that targeted organs or parts thereof could be viewed and reached during laparoscopic procedures. The following features make the LNTPI unique compared to standard blunt dissectors used in laparoscopy: 1. The tip of the LNTPI is coarse and not smooth. The tip has diagonal, spiral ridges from the sides which are carried onto the tip converging as a single spiral at the center of the tip, creating a pattern resembling that of a screw; 2. The ridges of the LNTPI are comprised of asymmetrical triangular ridges with an acute angle at the apex that may be leaning along with or against the rotation of the spiral; 3. The tip of the LNTPI is made of tungsten carbide metal instead of stainless steel; 4. Dissection can be done in the usual up, down, left, and right motions as standard dissectors; 5. The side of the LNTPI can be used to "peel" tissue by using the ridges on its side combined with a twisting movement. This maneuver cannot be performed using standard dissectors; and 6. The tip of the LNTPI can perform circumferential dissection when used with a twisting movement causing it to engage tissue like a "drill" along the natural tissue plane. The ridges that converge into a single spiral at the tip of the invention appear like a screw and with the proper twisting movement have a similar effect on tissue. Because of the texture, design, and material used for the tip of the LNTPI, it has the following advantages over standard dissectors: The LNTPI can engage tissues more easily even if the tissues are slippery due to the presence of blood or fluids. The LNTPI can be used to engage tissues through a twisting motion which motion allows the tissues to be engaged in a specific manner that defines natural tissue dissection planes. The LNTPI can insinuate / "peel" tissue by using the side spiral ridges in combination with a twisting movement. The LNTPI can perform circumferential dissection by using the tip and the convergence of the spiral ridges at the center of the tip in combination with a twisting movement. The transfer of lateral shear force to the tissue at various angles (45, 90, and 180 degrees) when using the LNTPI is significantly higher whether the motion is by a sweeping motion or twisting of the instrument, allowing it to insinuate better than standard instruments, especially in a wet field. Hand movements needed in insinuating tissue using the LNTPI are different from the usual hand movements when using standard dissection instruments. The hand movements in using LNTPI require less muscular effort and repetitiveness, thus preventing muscle fatigue and repetitive use injury among surgeons. The instrument is reusable, as compared to dissectors that have fabric at the tip, which must be disposed of and replaced once the fabric tip fully absorbs the blood or other fluid in the wet tissue surface.

An ultrasound imaging system (102) includes a single transducer array (110) having a long axis and configured to transmit and receive in a first mode to acquire real-time ultrasound images of a sagittal plane during a surgical procedure, or in a second mode, acquiring 3D ultrasound data comprising a plurality of sagittal planes by rotating the single transducer array about an axis parallel to the long axis of the transducer array; a resampler (202) configured to resample the 3D ultrasound data and generate a set of resampled ultrasound planes that are approximately orthogonal to the surface of tissue of interest; a divider (204) configured to segment a first profile of the tissue of interest in the set of resampled ultrasound planes; and a registration engine (206) configured to register the first profile with a second profile of the tissue of interest in the pre-operative 3D MR image data and generate a fused 3D image.

Provided herein are methods, devices, and systems that may improve optical resolution when imaging through a thickness of samples. A method for generating a depth profile of a tissue of a subject may comprise using an optical probe to transmit an excitation light beam from a light source towards a surface of the tissue; using one or more focusing units in the optical probe to simultaneously adjust a depth and a position of a focal point of the excitation light beam along a scanning path; detecting at least a subset of the signals generated upon contacting the tissue with the excitation light beam; and using one or more computer processors programmed to process the at least the subset of the signals to generate the depth profile of the tissue.

The invention provides a tissue sealing, isolating and repairing matrix and a preparation method thereof, and belongs to the technical field of tissue matrixes. Comprising the following steps: (1) extracting collagen in animal tissues by an enzymolysis method; (2) dissolving with an acid solution or a phosphate buffer solution to prepare a collagen solution; (3) removing bubbles in the collagen solution by adopting centrifugation or vacuum; (4) spreading the defoamed collagen solution in a flat mold, and slowly dehydrating step by step to form a collagen film; (5) cross-linking by adopting a chemical agent or a physical method; (6) soaking and cleaning; (7) slowly removing water step by step to obtain a collagen matrix with a thickness of 5-30 [mu] m; and (8) slitting, packaging and sterilizing to prepare the tissue sealing, isolating and repairing matrix, which is extremely thin and extremely soft in texture, shows extremely strong adhesion and adaptability to the tissue boundary, can be spontaneously and tightly attached to the tissue surface, and effectively prevents the problems of air leakage, low-pressure seepage, errhysis and the like.

Methods of transplanting target cells into a subject in need thereof. The methods generally comprise creating a sealed transplantation space by attaching an acellular membrane to the surface of a visceral organ or tissue in the subject in a manner such that a sealed space is created between the surface of the visceral organ or tissue and the membrane, and inserting a mixture of support cells and the target cells into the sealed transplantation space.

In an aspect, a method for applying beta-alanine to a tissue surface is described. The method may comprise applying a composition comprising from about 0.01 % w / w to about 5.0 % w / w beta-alanine to a tissue surface. The beta-alanine may comprise between about 0.08 % w / w to about 2 % w / w. The tissue surface may be suffering from a condition. The tissue surface may be from the group consisting of epidermis, mucosal membrane, respiratory tract lining, urinary tract lining, and reproductive tract lining. In another aspect a composition may comprise from about 0.01 % w / w to about 5.0 % w / w beta-alanine; water; an emulsifying component; and a fat. The fat may be an emollient or a moisturizing component.

The invention relates to a selective cell killing device based on surface and interface pH regulation and application thereof. The method comprises the following steps: depositing a noble metal material capable of regulating and controlling extracellular proton concentration on one side of a substrate to form a regulation and control layer, and connecting the regulation and control layer to an external preset dynamic voltage control unit through a wire; the regulation and control layer is attached to the surface of the tissue; a dynamic voltage is periodically applied to the regulation and control layer through an external preset dynamic voltage control unit, so that the pH value of the interface microenvironment of the regulation and control layer and tissue cells is alternately changed between 5 and 8, and accurate selective killing of the cells is realized. A preset dynamic voltage control scheme based on a cancer cell glycolysis oscillation period is adopted, so that the pH value of a local surface interface can be regulated and controlled according to a set period, the excretion of lactic acid and protons of cancer cells is continuously and effectively interfered, and the cancer cells are prevented from generating adaptive reaction.

An implantable energized medical device configured to be held in position by a tissue portion of a patient, the medical device comprising: a first portion configured to be placed on a first side of the tissue portion, the first portion having a first cross-sectional area in a first plane and comprising a first surface configured to face a first tissue surface of the first side of the tissue portion, a second portion configured to be placed on a second side of the tissue portion, the second side opposing the first side, the second portion having a second cross-sectional area in a second plane and comprising a second surface configured to engage a second tissue surface of the second side of the tissue portion, and a connecting portion configured to be placed through a hole in the tissue portion extending between the first and second sides of the tissue portion, the connecting portion having a third cross-sectional area in a third plane and a third surface configured to engage the first tissue surface of the first side of the tissue portion, wherein the connecting portion is configured to connect the first portion to the second portion, wherein: the first, second, and third planes are parallel to each other, and the third cross-sectional area is smaller than the first and second cross-sectional areas, such that the first portion, second portion and connecting portion are prevented from travelling through the hole in the tissue portion in a direction perpendicular to the first, second and third planes.

Disclosed herein are devices and methods for assessing the surface of a target cardiac tissue and for delivering a tissue anchor to cardiac tissue at a preselected depth within the myocardium in a beating heart procedure. In one variation, an anchor delivery device comprises an elongate body, a tissue anchor disposed within a first longitudinal lumen of the elongate body, and a tissue depth indicator slidable within a second longitudinal lumen of the elongate body. The tissue depth indicator has a first configuration that indicates the boundary of the surface of the target tissue and a second configuration that indicates when the distal tip of the elongate body has been advanced to a preselected depth into the target tissue. In some variations, a tissue depth indicator may also be configured to resist or limit the penetration of the delivery device into tissue after a preselected depth has been reached.

Embodiments of the present disclosure may include a system for associating dental and medical data the system including a processor. Embodiments may also include a memory containing instructions that instruct the processor to receive dental data including a plurality of dental images representative of at least a surface of dental tissue of a patient. Embodiments may also include receive medical data representative of the patient. Embodiments may also include generate training data as a function of a correlation between the dental data and the medical data. Embodiments may also include input the training data into a machine learning algorithm. Embodiments may also include train a machine learning model as a function of the training data and the machine learning algorithm.