378 results about "Tissue surface" patented technology

A catheter adapted or high density mapping and / or ablation of tissue surface has a distal electrode array with offset spine loops, each spine loop having at least a pair of linear portions and a distal portion connecting the pair of linear portions, and one or more electrodes on each linear portion. The linear portions of the plurality of offset spine loops are arranged in-plane a single common plane, and the distal portions of the plurality of offset spine loops are arranged off-plane from the single common plane.

Apparatus comprising a housing, at least one needle arranged for reciprocal motion between a retracted position and an extended position to penetrate an animal tissue surface when in the extended position, and a sealing device defining a channel through which a movable shaft extends to move the at least one needle in the reciprocating motion, wherein the sealing device serves to form a seal between the housing and the movable shaft. A corresponding method of preventing cross-contamination within apparatus for minimally invasive treatment of skin is also disclosed.

The invention discloses an unmanned aerial vehicle methane traceability monitoring model inversion method and system, and a storage medium. The method comprises the following steps: S1, dividing a research area box type monitoring space based on a research point source or an unorganized surface source; s2, planning an unmanned aerial vehicle planning route in a box type monitoring space of the research area in a layered manner, and starting an unmanned aerial vehicle to execute an unmanned aerial vehicle detection task; s3, constructing a research area box type monitoring simulation space in the geographic space model, extracting longitude and latitude and height information as position information, and extracting methane concentration data, air density data and wind speed data as three attributes of a midpoint of the research area box type monitoring simulation space; s4, performing grid subdivision and interpolation processing on the box type monitoring simulation space in the research area; and S5, performing calculation and inversion by using the methane inversion calculation model to obtain the methane emission flux of the box type monitoring space in the research area. According to the method, through layered methane data monitoring and model data inversion, the methane emission flux above the mining area can be rapidly and accurately obtained.

The invention discloses self-adaptive Janus supramolecular hydrogel, a preparation method and application of the self-adaptive Janus supramolecular hydrogel as a wet tissue surface adhesive. The hydrogel has an integrated structure and two asymmetric surfaces: an adhesion surface and an anti-adhesion surface. The method is suitable for the wet tissue surface bonding field.

The invention provides a radio frequency therapeutic instrument control method, and relates to the technical field of medical instruments, and the method comprises the steps: obtaining the dynamic change information of a target tissue surface temperature field in real time through collecting the dynamic temperature data of a target tissue surface; setting a temperature control constraint of the radio frequency therapeutic apparatus according to a plurality of temperature deviation indexes corresponding to the temperature sudden change area; performing region communication on the heat distribution rule in the temperature mutation region to obtain a temperature compensation boundary corresponding to the temperature mutation region on the surface of the target tissue, and determining a temperature change compensation trend of the radio frequency therapeutic apparatus according to the temperature compensation boundary and the dynamic temperature data; and determining multi-stage radio frequency treatment signals of the radio frequency treatment instrument in different temperature fields according to the temperature control constraint and the temperature change compensation trend, and matching temperature control strategies of the radio frequency treatment instrument according to the multi-stage radio frequency treatment signals. According to the invention, intelligent matching of temperature control strategies can be realized through multi-stage radio frequency treatment signals, so that the stability of temperature control of the radio frequency therapeutic apparatus is improved.

The invention discloses an invisible appliance based on a transparent piezoelectric film and a design method thereof. A perioral muscle pressure sensor is installed on the lip / cheek lingual surface of teeth of the invisible orthodontic appliance, an occlusal force sensor is installed on the occlusal surface, and a tooth surface counter-acting force sensor is installed on the inner side tissue surface, so that dynamic changes of perioral muscle pressure, occlusal force and orthodontic force can be monitored in real time. The invisible orthodontic appliance provided by the invention integrates a sensor with high piezoelectric coefficient and high flexibility, has high sensitivity and accuracy, can be used for testing dynamic changes of orthodontic mechanics and evaluating the influence of perioral muscle pressure, occlusal force and the like on treatment during physiological processes of chewing, breathing, swallowing, language and the like of a patient; a doctor optimizes an orthodontic scheme through the PC terminal and pays attention to the association between oral functional mechanics and malocclusion, bad oral habits, bruxism, temporomandibular joint disorder and other diseases, and the efficiency and accuracy of oral health management are improved.

According to the flexible array type external field program control nerve stimulation device, the preparation method and the application thereof, the flexible array type external field program control nerve stimulation device comprises a flexible substrate layer and a stimulation response fiber array layer, and the stimulation response fiber array layer is prepared from a functional material capable of converting external field energy such as ultrasound, magnetism and light into electric energy; the flexible substrate layer with high flexibility is adopted, so that the flexible substrate layer can be matched with the surface of a nerve target tissue in a conformal manner; the stimulation response fiber array layer integrated on the flexible substrate layer in an array arrangement mode can meet the stimulation spatial resolution of neuron and even sub-neuron precision, has the characteristics of excellent flexibility, biocompatibility, passivity and wireless performance, can provide nerve electrical stimulation signals with high spatial resolution, and can be applied to the field of nerve electrical stimulation. The high-resolution nerve electrical stimulation device can be in conformal fit with the irregular surface of nerve soft tissue, and is suitable for high-resolution nerve electrical stimulation of different parts such as eyes, the brain and peripheral nerves.

An anvil buttress loading system includes an anvil assembly having a snap clip disposed on a tissue facing surface, a loading tool including a clip roller extending proximally from a support plate, and an anvil buttress including a buttress body. The snap clip is movable between closed and open positions having generally concave and convex shapes, respectively, relative to the tissue facing surface. The anvil buttress is releasably retained on the loading tool and is transferrable from the loading tool to the anvil assembly such that the buttress body is captured between the snap clip and the tissue facing surface of the anvil assembly. The snap clip is movable from the closed position to the open position by the clip roller when advancing the loading tool onto the anvil assembly and from the open position to the closed position when separating the loading tool from the anvil assembly.

The invention belongs to the technical field of biological medicines and medical cosmetic materials, and discloses an alginic acid-based facial filler which comprises the following components in percentage by mass: 13-26% of an alginic acid-based material, 40-43% of polylactic acid microspheres and 34-44% of a freeze-drying protective agent, the alginic acid-based material comprises sodium alginate and oxidized sodium alginate, the G / M ratio of the sodium alginate to the oxidized sodium alginate is 3: 1-1: 1, and the mass ratio of the oxidized sodium alginate to the sodium alginate is 2: 1-1: 2. According to the preparation method, an alginic acid-based material with biodegradable stimulation characteristics is used, aldehyde groups of oxidized sodium alginate can generate Schiff base reaction with amino groups on the tissue surface so as to contribute to anchoring a target part, and the alginic acid-based material and polylactic acid microspheres can act on cells to promote collagen secretion; the face filler also has timely filling performance and gradient degradation performance. The invention also provides a preparation method of the alginic acid-based facial filler.

The invention provides efficient gelatin hemostatic microspheres as well as a preparation method and application thereof, the preparation method comprises the following steps: mixing a gelatin solution with a tannic acid solution, and uniformly stirring to obtain a tannic acid modified gelatin aqueous solution; uniformly mixing span-80 with liquid paraffin to obtain an oil phase; adding the tannic acid modified gelatin aqueous solution into an oil phase, and uniformly stirring to obtain a mixed solution; the mixed solution is subjected to a cross-linking reaction under the ice bath condition, after the cross-linking reaction is completed, a reaction solution and acetone are mixed, liquid paraffin is removed after standing, and the tannic acid modified hemostatic microspheres are obtained after drying; mixing the tannic acid modified hemostatic microspheres with an adsorbent, and dehydrating to obtain the gelatin hemostatic microspheres. The prepared gelatin hemostatic microspheres can be attached to the surface of tissue and have the effects of high water absorption and rapid hemostasis.

The invention belongs to the technical field of biological materials and ultrasonic printing, and particularly discloses a biological adhesive for ultrasonic printing and preparation and application thereof. The biological adhesive comprises a heat-sensitive main body material and a chemical adhesion component, the heat-sensitive main body material comprises hydroxybutyl chitosan, and the chemical adhesion component comprises polyacrylic acid-N-hydroxysuccinimide ester. The bioadhesive has excellent ultrasonic responsiveness, formability and bioadhesion performance, directional deposition, in-situ solidification and tissue surface adhesion can be achieved in a non-contact and accurately-controlled ultrasonic printing system, and the bioadhesive is suitable for various biomedical scenes such as tissue repair, minimally invasive medicine, biological device construction and drug delivery interface printing.

The invention relates to the technical field of optical imaging, in particular to a transparent biological tissue elasticity measuring method and device.The method comprises the steps that M-mode images at different excitation depths are collected at the same lateral position of the tissue surface based on excitation of an excitation source at different depths in a transparent tissue, and comparing the time difference of the elastic waves generated at different excitation depths reaching the same depth in the imaging area on the tissue surface, and calculating the propagation velocity of the elastic waves in the transparent tissue to obtain the elastic modulus in the transparent tissue. Therefore, the problems that in the related technology, due to the fact that the surface of the transparent tissue has special tissue structure characteristics or optical characteristics, optical imaging can only conduct imaging on the position near the surface of the transparent tissue, the interior of the transparent tissue cannot be observed, and propagation of elastic waves in the transparent tissue cannot be detected are solved; the elastic information in the transparent tissue cannot be obtained, so that the medical diagnosis result is influenced.

Disclosed is a novel strategy for engineering tissue adhesives in which molecular building blocks are manipulated to allow for precise control and optimization of the various aforementioned properties without any tradeoffs. To introduce tunable mechanical properties and robust tissue adhesion, the hydrogel network presents different modes of covalent and noncovalent interactions using N-hydroxysuccinimide ester (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), and Fe3+ ions. Through combining and tuning different molecular interactions and a variety of crosslinking mechanisms, we were able to design an extremely elastic (924%) and tough (4697 kJ / m3) multifunctional hydrogel that could quickly adhere to wet tissue surfaces within 5 sec of gentle pressing and deform to support physiological tissue function over time under wet conditions.

The invention relates to the technical field of medical image processing, in particular to a gynecological endoscope image intelligent analysis and cervical lesion precise diagnosis system. Comprising an image enhancement module, a differential geometric feature extraction module, a topology preserving manifold learning module, a curvature-blood vessel correlation analysis module, a biopsy point accurate positioning module, a real-time intelligent auxiliary diagnosis module, a clinical feedback module and a self-adaptive optimization module. Micro morphological change features are extracted through multi-scale curvature analysis; a topology sensitive encoder and a manifold alignment decoder are adopted, and a key topology structure is kept; establishing a correlation model of the tissue surface curvature change and the blood vessel morphology, and analyzing differential morphological characteristics; determining an optimal biopsy position based on the comprehensive characteristics; according to the method, the diagnosis result and basis are generated, visual display is provided, the detection rate of cervical lesions, especially early minimal lesions, is remarkably increased, the missed diagnosis rate is reduced, and multi-point biopsy is reduced.

The invention provides a sampler and a sampling method for collecting biological molecules on the surface of tissue, the sampler is provided with a sampling direction, the sampler comprises a main body, the main body is provided with an arc-shaped track, the center of the arc-shaped track corresponds to the center of the main body, and the sampling direction of the main body is equal to that of the arc-shaped track in one length direction of the track. And the radius of the arc-shaped track is gradually increased or decreased. According to the sampler for collecting the biological molecules on the surface of the tissue, a plurality of sampling needles are arranged, a sampling liquid drop corresponding to a sampling center can be formed and maintained among the output ends of the plurality of sampling needles, and a non-embedded sampling mode is realized through contact between the liquid drop and the surface of the biological tissue; the damage to the integrity of key biomolecules possibly caused by a traditional method is avoided, the acquisition of high-fidelity biomolecules is facilitated, and the sampler can reduce physical disturbance and mechanical damage to fragile tissues to the maximum extent.

The invention belongs to the technical field of medical robots and minimally invasive surgery, and provides a robot control system and method for blue laser vaporization surgery of prostatic hyperplasia. Mapping the nuclear magnetic image volume data to a deformation field under an ultrasonic acquisition coordinate system, and deforming the preoperative nuclear magnetic image to an intra-operative ultrasonic space by using the deformation field to complete image registration; fusing the registered image with a stereoscopic vision system; the spatial depth of the surface of the target tissue is obtained from the endoscopic image so as to supplement navigation information; according to the utility model, the prostate deformation and probe posture change adaptive capacity in an operation is improved, the real-time visual closed-loop regulation and control capacity is improved, and the characteristics of small light spots, shallow heat diffusion, excellent hemostasis and the like of blue laser are combined, so that the vaporization and hemostasis precision in a tiny blood vessel dense area is ensured, and the problems of large tissue trauma and the like are avoided.

The invention discloses a self-adaptive endoscope system and method based on photoacoustic image structure feature recognition, and relates to the technical field of photoacoustic endoscopic imaging, the system comprises a control system, a light source system, an endoscope probe, a feedback system, a signal processing system and a computing terminal; the control system synchronously triggers the light source system and the signal processing system, the light source system comprises a white light source and a laser, laser exciting light enters the endoscope probe through a single-mode optical fiber, scanning is controlled by a micro-electro-mechanical system (micro-electro-mechanical system scanning micro-mirror) scanning micro-mirror in the probe, scanning light enters the focusing lens group through the relay lens, and the focusing lens group is connected with the signal processing system through the relay lens. A to-be-imaged tissue surface is irradiated by the liquid lens, echo signals are acquired and processed by the signal processing system, photoacoustic image reconstruction is completed, the feedback system is connected with the liquid lens in the probe, and optical signals of optical images are acquired and reconstructed by an eyepiece at the top of the endoscope and a matched CMOS (complementary metal oxide semiconductor).

The method comprises the following steps: fixing with a pre-fixing solution, wrapping and forming with a solid agent, fixing with a fixing solution, embedding with an embedding agent, decomposing melanin with a melanin decomposing solution, pre-decoloring with a pre-decoloring solution, decoloring with a decoloring solution, and eluting with a rinsing solution. The invention provides a melanin removing method capable of effectively avoiding retina RPE layer cell exfoliation, protein denaturation and nucleic acid degradation. The method mainly comprises the following steps: keeping the original state of tissue cells by adopting a pre-fixing solution, keeping the complete tissue structure by adopting a solid agent, decomposing melanin particles by adopting a melanin decomposing solution composed of various extracts, separating melanin by adopting a pre-decoloring solution and a decoloring solution, eluting the melanin decomposed on the surface of the tissue by adopting a rinsing solution, and the like. On the premise that the retina tissue structure is intact and protein, nucleic acid and cell structures on the surface of the tissue section are not damaged, melanin particles in the tissue section are effectively decomposed, the biological activity of various organelles on the surface of the section is kept, and the requirements of subsequent chemical staining of various tissues are met.

The invention relates to the technical field of planting bridges, and particularly discloses a hollow planting bridge and a preparation method thereof. The preparation method comprises the following steps: acquiring an initial model; the initial model is imported into MaterialiseMagics software, and an internal hollow structure is designed; preparing a planting bridge frame by using an additive manufacturing technology; the free ends of the lingual side, the palatal side or the two sides of the planting bridge are provided with slag discharging openings, and the slag discharging openings are far away from the screw channels, the edge lines and the tissue surfaces; and after the internal supporting material is removed, the slag discharging opening is sealed through resin. The hollow planting bridge frame comprises a planting bridge frame; a hollow structure; the connecting base is in the form of a preparation body or a complete tooth; the number of the screw channels is matched with that of the implants; the number of the implant abutment interfaces is matched with that of the implants; and the residue discharging openings are formed in the free ends of the tongue side, the palate side or the two sides of the planting bridge frame, and the residue discharging openings are sealed by resin. Therefore, the problems that in the prior art, a bridge frame is heavy, and the burden on an implant is large are solved.

Systems and methods are provided for performing 3D intracorporeal ultrasound imaging of tissue surfaces, such as tissue surfaces located inside a joint capsule during arthroscopic surgery. An intracorporeal ultrasound probe is provided having a rotatable distal region supporting an ultrasound transducer array. The ultrasound array is controlled to collect image data at several elevation angles while rotating the distal region of the probe, thereby acquiring a local 3D image dataset spanning a local 3D volume associated with the current probe pose. This process is repeated as the probe pose is varied, resulting in a set of local 3D image datasets, each corresponding to a different probe pose. The local 3D image datasets are processed to segment tissue surface contours and generate a corresponding set of surface tiles. The surface tiles are processed and combined to generate a composite 3D image, optionally based on input from one or more sensors.

The invention provides an anastomotic stoma reinforcing device as well as a preparation method and application thereof. The anastomotic stoma reinforcing device comprises a reinforcing material layer, a connecting material layer and a release film which are sequentially stacked, wherein the connecting material layer comprises a hydrophobic adhesive layer, a carrier layer and a waterproof adhesive layer which are sequentially stacked, and the hydrophobic adhesive layer is in contact with the reinforcing material layer. When the anastomotic stoma reinforcing device is used, the release film of the anastomotic stoma reinforcing device is peeled off, the reinforcing material layer can be fixed to the nail bin face and / or the nail anvil face of an anastomat by means of the waterproof glue layer, due to the fact that the reinforcing material layer has hygroscopicity and can be completely wetted after making contact with liquid on the tissue surface, the reinforcing material layer and the hydrophobic glue layer are separated, and therefore the anastomotic stoma is reinforced. However, the material of the anastomat does not absorb moisture, the connecting material layer is still firmly adhered to the anastomat and is not easy to separate, and when the anastomat is taken out, the connecting material layer is taken out along with the anastomat, so that the problems of slow postoperative recovery and the like caused by connecting material residues are avoided.

The invention discloses a Transform-based wet tissue surface defect real-time detection method. The method comprises the following steps: acquiring category information and a detection image of a to-be-detected wet tissue; the detection image comprises a visible light image and a near-infrared image; according to the category information of the to-be-detected wet tissue, acquiring category features through a preset category feature information base, and encoding the category features to generate category feature vectors; performing feature extraction on the visible light image and the near-infrared image to obtain visible light features and near-infrared features; based on the category feature vector, dynamically fusing the visible light feature and the near-infrared feature through a cross attention mechanism to generate a fused feature; and based on the fusion features, generating a wet tissue surface defect detection result through a preset defect detection model. According to the method, the accuracy and efficiency of detecting the surface defects of different types of wet tissues can be effectively improved by combining the category feature prior with the visible light feature and near-infrared feature fusion method.

Systems and methods are provided for performing optical coherence tomography (OCT) angiography for the rapid generation of en-face images. According to one example embodiment, differential interferograms obtained using a spectral domain or swept source OCT system are convolved with a Gabor filter, where the Gabor filter is computed according to an estimated surface depth of the tissue surface. The Gabor-convolved differential interferogram is processed to produce an en-face image, without requiring the performing of a fast Fourier transform and k-space resampling. In another example embodiment, two interferograms are separately convolved with a Gabor filter, and the amplitudes of the Gabor-convolved interferograms are subtracted to generate a differential Gabor-convolved interferogram amplitude frame, which is further processed to generate an en-face image without performing a fast Fourier transform and k-space resampling. The example OCTA methods disclosed herein are shown to achieve faster data processing speeds compared to conventional OCTA algorithms.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

The invention discloses a preparation method and application of collagen derivative and polysaccharide substance compounded self-gel hemostatic powder, and relates to the field of biomedical materials. Aminated collagen derivatives and aldehyde polysaccharide substances are subjected to a Schiff base reaction through amino groups and aldehyde groups; further obtaining the Schiff base cross-linked aminated collagen derivative-aldehyde polysaccharide hydrogel, freeze-drying, and grinding into powder, so as to obtain the self-gel hemostatic powder. The self-gel hemostatic powder disclosed by the invention forms hydrogel in a wound tissue for adhesion and sealing, so that rapid hemostasis is realized, postoperative adhesion at the wound tissue is avoided, and healing of a wound is facilitated; after hemostasis is completed, the self-gel powder can be dissociated and removed from the tissue surface, and the risk that thrombus is formed and immunological rejection is caused is reduced; after hemostasis is completed, the hemostasis powder can be metabolized and absorbed by a human body along with thrombus, so that the residue of the hemostasis powder in the body is reduced, and the safety is improved.

The present invention relates to a treatment apparatus and a method of controlling the same, and provides a treatment apparatus including an insertion unit formed in such a way as to be inserted into a tissue through a tissue surface, a bending sensing unit sensing bending of the insertion unit occurring during insertion, and a controller controlling the insertion operation of the insertion unit based on information sensed by the bending sensing unit, and a method of controlling the same. In accordance with the present invention, there is an advantage in that a treatment effect can be improved because treatment can be performed in the state in which the insertion unit has been inserted into an accurate target location.

The invention discloses a preparation method and application of two chemical crosslinking type injectable hemostatic sealant. According to the invention, four-arm polyethylene glycol succinimide glutaric acid ester (TPEG-SG) and carboxymethyl chitosan (CMCS) are taken as main materials, and calcium chloride is added or not added, so that two injectable hemostatic sealing adhesives with chemical crosslinking characteristics are designed and prepared. After the two kinds of sealant are injected to a bleeding part, rapid and efficient gelation and tissue adhesion can be achieved through chemical crosslinking of carboxyl activating groups of the four-arm polyethylene glycol succinimide glutaric acid ester, amino groups in carboxymethyl chitosan and amino groups on the surface of tissue, and therefore wounds are effectively sealed. Compared with a traditional hemostatic material, the two sealing glues have the characteristics of rapid in-situ wound formation, strong tissue adhesion, rapid hemostasis and the like, the problems of poor adhesion performance and poor hemostasis capability of a conventional hemostatic material are solved, and the hemostatic material is more suitable for hemostasis of non-compressible hemorrhage in a special wound environment and has good clinical and military application prospects.

The invention discloses a medical pressure-sensitive adhesive patch based on citric acid, a preparation method and application, the medical pressure-sensitive adhesive patch is composed of an adhesion layer and an anti-adhesion layer, and the thickness ratio of the adhesion layer to the anti-adhesion layer is 1: 1-100: 1; the adhesion layer is obtained by polymerizing a citric acid unit and a polyhydroxy compound unit; the hydrophobic high-molecular polymer is selected from at least one of a polylactic acid-glycolic acid copolymer, polylactic acid, polyurethane and polyether urethane. According to the preparation method, three carboxyl groups in the citric acid not only can be used for esterification reaction with polyhydric alcohols to form a network, but also can provide excellent adhesive force for contact between the adhesive patch and the tissue surface through electrostatic interaction or hydrogen-bond interaction. The anti-sticking layer prepared from the hydrophobic high-molecular polymer can effectively resist invasion of external moisture and bacteria, so that the service time of the adhesive patch is prolonged; meanwhile, the anti-sticking layer can also play a supporting role, so that the mechanical strength of the adhesive tape is improved.

The invention relates to the technical field of medical image processing, in particular to a medical image acquisition and analysis method and system for an endocrine patient, and the method comprises the following steps: uniformly irradiating the thyroid tissue of the endocrine patient with laser with a target wavelength, detecting and recording the intensity of light reflected back from the tissue surface, and performing initialization mapping on the internal structure of the tissue to obtain an original medical image of the speckles. According to the method, the light intensity change in the speckle image is analyzed, pixel-level calculation is carried out, and tiny change in the tissue is identified in a detailed mode, so that the information amount of the medical image is increased, high-precision basic data is provided for subsequent lesion analysis, and the accuracy of the medical image is improved through the light intensity distribution data. The brightness change between pixels is compared to mark different areas, pathological features are distinguished through texture analysis, the disease early detection and classification ability is improved, and doctors can make a more accurate recovery scheme for patients.