23 results about "Bacterial colonization" patented technology

The present disclosure provides a catheter system including a plurality of fenestrations along the shaft of the catheter, wherein the fenestrations allow for continuous or intermittent infusion of antiseptics and / or antibiotics to avoid and treat bacterial colonization or infection of the subcutaneous tract and to minimize subcutaneous tunnel colonization and fibrin sheath in symptomatic or asymptomatic patients. The present catheter system can also include a removable abrasive component on the catheters tip to assist with mechanical debridement of subcutaneous tract and intravascular fibrin sheath.

The present disclosure relates generally to compositions comprising Bacillus pumilus having a positive impact on animal performance parameters, the use of Bacillus pumilus for preventing, reducing or controlling bacterial colonization or infection, a method of improving one or more animal performance parameters, and a kit. In particular, the present disclosure relates to Bacillus pumilus DSM 34300 and DSM 34299.

The invention relates to the technical field of microorganisms, and discloses a bacterial strain for improving children allergy and relieving inflammation and application thereof.A BB1000 bacterial strain is compounded with a soluble dietary fiber mixture, an inulin enzymolysis product, oat beta-glucan and tremella polysaccharide according to a determined proportion, a compound polysaccharide composition is prepared through freeze-drying, and a powder product suitable for children to take is prepared. According to the composition, through the synergistic effect of polysaccharide components, a composite gel network is formed in the intestinal tract to protect a BB1000 strain, diversified prebiotics are provided to support strain colonization, and mucous membrane layer repair, barrier function enhancement and immunoregulation are achieved at the same time.

The application discloses a medical tissue glue modified formula and injection method for treating esophageal varices, and relates to the field of tissue glue; the medical tissue glue modified formula and injection method for treating esophageal varices introduce polyoxyl glycol as a modifier, not only reduce the brittleness and hardness of n-butyl alpha-cyanoacrylate after polymerization, make the formed vascular embolus more flexible, significantly reduce the cutting risk of traditional hard glue block to thin-walled mucosa, thereby reduce the incidence of postoperative glue leakage ulcer and rebleeding; at the same time, polyoxyl glycol itself as a hardener can synergistically damage the vascular endothelium, accelerate thrombosis and vascular fibrosis, and improve the long-term occlusion effect; secondly, the addition of dragon's blood extract or nano-silver and other antibacterial components in the formula can actively inhibit local bacterial colonization, effectively reduce the risk of postoperative sepsis for the clinical pain points of low immunity and easy infection of patients with cirrhosis.

The invention provides a method for constructing an artificial breeding schizothorax wangchizoides intestinal flora structure to digest field algae food, which comprises the following steps: A, collecting healthy adult schizothorax wangchizoides from the field as a donor, and preparing the intestinal content of the adult schizothorax wangchizoides into a coprophilous fungus suspension; selecting artificially fed healthy schizothorax brachypodum juvenile fish as a receptor; b, within 10-20 days, performing coprophilous fungus transplantation on the juvenile schizothorax wangchizoides in an overnight soaking manner every 3 days, and randomly sampling and selecting the schizothorax wangchizoides every 5 days in the afternoon for intestinal sample collection; and C, evaluating the intestinal flora in the sample, and if the receptor intestinal cellulose bacteria are successfully colonized, releasing to a natural river.

The application relates to the technical field of dental implants, in particular to a trans-zygomatic implant and a processing technology thereof, and the processing technology comprises variable-distance multi-stage sand blasting and acid etching surface treatment on an anchoring part with threads of the trans-zygomatic implant and electrochemical polishing surface treatment on an extension part without threads. The trans-zygomatic implant is treated by variable-distance multi-stage sand blasting combined with acid etching, so that a uniform micron-level rough base and a multi-stage micropore structure can be formed on the titanium surface, osteoblast adhesion and differentiation are facilitated, the early bone combination speed is accelerated, the combination strength is improved, the early implant loosening risk is reduced, the extension part of the trans-zygomatic implant is treated by electrochemical polishing, a smooth surface can be obtained, plaque adhesion and bacterial colonization are greatly reduced, the implant peri-implantitis risk is reduced, and soft tissue adhesion is promoted; the dual optimization of bone anchoring and tissue adhesion is realized, and the long-term function and health of the trans-zygomatic implant under complex stress are guaranteed.

The invention discloses a preparation method and application of an antibacterial biofilm liquid dressing with a hemostatic effect and capable of quickly targeting bacteria. The antibacterial biological membrane liquid dressing is prepared from the following components in percentage by weight: 5 to 10 percent of TMG-Ag < + >-EVs coordination liquid, 60 to 70 percent of ramie fiber pulp with the solid content of 0.2 to 0.5 percent, 10 to 20 percent of ramie water extract and 0.15 to 2 percent of povidone K30, wherein the TMG-Ag < + >-EVs coordination liquid contains betaine with the final concentration of 50 to 70 mM, silver ions with the final concentration of 20 to 30 [mu] g / ml and a staphylococcus epidermidis bacterial membrane with the final concentration of 500 to 1000 ng / ml. The betaine, the silver ions and the ramie are combined, bacterial biofilms can be efficiently destroyed, bacterial colonization is inhibited, the toxicity of the silver ions is reduced, and the composition is suitable for prevention and treatment of infection of various wound types such as skin and mucous membrane injuries.

This invention provides an external fixation frame for limb fractures, relating to the field of fracture fixation technology. It includes a main fixation component, a secondary fixation component, a length adjustment component, an angle adjustment component, a fixation element, and a movement component. The main fixation component includes a main fixation frame with a main adjustment groove on its long side and main through-channels on both its upper and lower sidewalls. The secondary fixation component includes a secondary fixation frame with a secondary adjustment groove on its long side and secondary through-channels on both its upper and lower sidewalls. The length adjustment component allows for adjustment of the distance between the two fixation positions, making it suitable for fractures of different lengths. Furthermore, the use of a drug-eluting silicone sleeve effectively inhibits early bacterial colonization, significantly reducing the risk of pin tract infection and secondary loosening.

The invention discloses a porous frame coating which comprises an implantable metal stent, and a mechanical enhancement layer is coated on the implantable metal stent; ethylenediamine is grafted on the polymer on the surface of the mechanical enhancement layer, and the MOF drug-loaded coating grows through a grafting reaction with the ethylenediamine. The surface of the implantable metal stent is coated with the mechanical enhancement layer coating, good biocompatibility and mechanical matching are achieved, the polymer and the surface of the implantable metal stent have good binding force, chemical grafting is conducted on the polymer and ethidene diamine, and therefore the MOF medicine carrying coating grows on the mechanical enhancement layer. The binding force between the MOF drug-loaded coating and the mechanical enhancement layer can be ensured, the MOF drug-loaded coating can simultaneously inhibit bacterial colonization and tumor cell proliferation by simultaneously releasing metal ions and drugs, and the MOF drug-loaded coating has good application prospects and economic benefits in preparation of implantation and intervention medical instruments for treating biliary tract diseases.

The present disclosure relates generally to compositions and methods using ent- testosterone. The disclosed ent-testosterone can be used to inhibit quorum sensing of bacteria. The present disclosure further relates to compositions and methods of treating bacterial infections or having a complicated condition due to bacterial colonization.

The present application relates to the field of biological medicine technology, and relates to a kind of oral squamous cell carcinoma related marker and drug screening method. By 5R 16S rRNA-seq analysis and representative fluorescence in situ hybridization technique verification, the abundance of Capnocytophaga leadbetteri (C. leadbetteri) in oral squamous cell carcinoma (Oral Squamous Cell Carcinoma, OSCC) tissue is significantly higher than that in normal tissue, and it can be used as the diagnostic marker of OSCC. The present application further clarifies the specific molecular mechanism of the bacteria promoting tumor progression, excludes environmental microbial interference through aseptic mouse model, and directly proves that C. leadbetteri single bacterial colonization can induce oral epithelial hyperplasia and barrier damage. Experiments confirm that the bacteria up-regulate chemotactic factors by activating TLR4 / MyD88 / NF-κB signaling axis, recruit neutrophils to form pro-tumor immune microenvironment. In vivo animal model confirms that after using BAY 11-7082 to inhibit NF-κB or using anti-Ly6G antibody to eliminate neutrophils, the tumor volume and weight are significantly reduced (P<0.01), and the present application provides a new treatment target and drug screening theoretical basis for OSCC.

The invention discloses a feed additive for antibiotic-free breeding as well as a preparation method and application of the feed additive. The additive takes dual-vector co-expression recombinant lactococcus lactis engineering bacteria as a core and is supplemented by microencapsulated functional small molecules. The recombinant engineering bacterium can synchronously express the fusion polypeptide and a single-chain antibody fragment, wherein the fusion polypeptide contains an N-terminal antibacterial functional domain, a flexible linker and a C-terminal immune enhancement functional domain, and antibacterial-immune synergy is realized; the single-chain antibody fragment aims at escherichia coli F18 adhesin and can specifically block pathogenic bacterium colonization. During preparation, the recombinant engineering bacteria are firstly prepared into freeze-dried powder, and then the freeze-dried powder is compounded with the microencapsulated functional micromolecules in proportion. Experiments show that the additive can remarkably improve the growth performance of weaned piglets, reduce the diarrhea rate, enhance the immune function and improve intestinal health, the effect of the additive is better than that of traditional antibiotics and a scheme of directly adding functional components, and efficient, safe and sustainable technical support is provided for antibiotic-free breeding.

The present disclosure provides for a method of treating a bacterial colonization or primary or secondary bacterial infection of an underlying skin disorder in a subject via the topical administration of a pharmaceutical composition comprising a therapeutically effective amount of an extract of the Croton lechleri tree. Additionally the present disclosure provides for a method of treating a bacterial colonization or primary or secondary bacterial infection of the nasal mucosa in a subject via the nasal administration of a pharmaceutical composition comprising a therapeutically effective amount of an extract of the Croton lechleri tree. Also provided are details of studies on the effectiveness of an extract of the Croton lechleri tree on bacterial pathogens.

This invention discloses a compound microbial preparation for controlling root-knot nematodes and promoting plant growth, as well as its preparation and application. Addressing the technical problems of existing biocontrol agents, such as lack of target optimization based on root-knot nematodes, unclear metabolite profiles, poor synergistic effects, and unstable insecticidal and growth-promoting properties, this invention screens *Polyspora pinki* and *Bacillus belye* for co-culture, and through inter-bacterial interactions, directionally enriches synergistic metabolites such as daidzein, isopentenyl adenine, and melatonin. When applied to the rhizosphere, this preparation reduces the root-knot index of cucumbers by ≥40% and increases the fresh weight of aboveground parts by ≥25%, significantly superior to single-strain or physical mixture systems. Furthermore, the product is flexible in form, possessing both viable bacterial colonization ability and metabolite stability; its activity retention rate is >80% after 90 days of storage at 35℃, making it suitable for various application methods such as root irrigation and seed coating, providing a highly efficient and stable technical solution for the green control of root-knot nematodes.

This invention discloses a dynamic covalent colloidal adhesive material, its preparation method, and its applications, belonging to the field of biomedical materials. This invention provides a novel method for constructing dynamic covalent colloidal adhesives (DCCGs) based on a reaction-induced self-assembly (RISA) strategy, and uses the prepared DCCGs for the combined treatment of periodontal inflammation and tooth demineralization. Experimental results show that the DCCGs prepared by this invention can adhere efficiently and exhibit outstanding functions in scavenging free radicals and pro-inflammatory molecules, inhibiting bacterial colonization, and promoting tooth remineralization. The DCCGs prepared by this invention can meet the needs of synergistic anti-inflammatory and promineralization treatment in oral cavity, providing a novel multifunctional integrated material for the treatment of periodontal diseases and laying the foundation for multi-disease co-treatment strategies.

This utility model belongs to the field of bone screws, specifically a bone screw structure. Addressing the issue that existing traditional dental bone screws have a smooth metal surface between the threads, which leads to poor contact between the smooth metal surface and bone tissue during installation, creating micro-gaps that facilitate bacterial colonization and can cause infection and inflammation, the proposed solution includes a bone screw body made of titanium alloy. The bottom outer surface of the bone screw body is coated with an HA coating, and the bottom outer surface of the bone screw body has threads for easy installation and fixation. The HA coating and reinforcing mechanism increase the contact area and friction between the bone screw and bone tissue. This design allows the bone screw to fit more tightly with the bone tissue after implantation, effectively reducing the formation of micro-gaps, thereby significantly improving the stability of the bone screw in the bone tissue, reducing the risk of loosening, and providing reliable anchorage for subsequent oral treatments (such as orthodontics).

The application belongs to the technical field of genetic engineering, and provides an oahs gene deletion strain and application thereof in prevention of Streptococcus suis type 2 infection.The oahs gene deletion strain, namely SC19-ΔOAHS, has very low virulence and is basically non-toxic.The mutant strain has basically no infection damage to mice when the mice are immunized with a large dose of live bacteria, and the antibody titer in the mice is obviously increased with the aid of an adjuvant, so that the immunoprotection can be successfully established.The immunoprotection established after a normal immunization procedure can help the mice effectively resist the infection of Streptococcus suis type 2, reduce the mortality and bacterial colonization in the body.The preparation method of SC19-ΔOAHS is simple, and the strain can be prepared in a short period of time, is simple to culture, and does not need other complex treatment as a vaccine, and can be used after washing and mixing with an adjuvant.SC19-ΔOAHS has the potential to be used as a live bacteria vaccine against Streptococcus suis infection in pigs.

The invention discloses a degradable ureteral stent and a preparation method thereof, and relates to the technical field of ureteral stents. According to the degradable ureteral stent, methylacryloylated gelatin and methylacryloylated sodium alginate are used as raw materials, double-crosslinking double-network hydrogel is prepared through photo-crosslinking and ionic crosslinking, and reinforced hydrogel is obtained through training in combination with an ammonium sulfate solution; the degradable ureteral stent is manufactured through a double-j-tube mold of an 8-shaped structure. According to the degradable ureteral stent, the degradation time of the stent is controlled to be 2-3 weeks, so that the problem that the stent is taken out in a secondary operation is avoided, the problems of bacterial colonization and scabbing on the surface of the ureteral stent can be solved, and due to the fact that the whole degradable ureteral stent is of an 8-shaped macrostructure, the degradable ureteral stent has excellent rebound resilience and good mechanical performance after being formed.

The invention discloses a preparation method of a polymer-based anti-fouling coating. The preparation method comprises the following steps: (1) pretreating the surface of a base material; (2) vertically putting the pretreated base material into a polymer solution, and coating by dipping and pulling; (3) placing the coated base material in an ethanol steam environment for standing and balancing treatment; (4) placing the base material treated in the step (3) in a closed environment containing deionized water to carry out hydration heat treatment, and then cooling to carry out gradient temperature treatment; and (5) cleaning the base material treated in the step (4) to obtain the polymer-based anti-fouling coating. According to the preparation method of the polymer-based anti-fouling coating, the anti-fouling coating is constructed on the surface of a base material through a specific technological process, the anti-fouling coating is high in hydrophilicity, the anti-fouling effect is 95% or above, and the clinical anti-fouling performance is remarkably improved; in addition, the anti-fouling coating is stable and uniform, and the risk of thrombus formation related to the instrument and the risk of bacterial colonization caused by coating missing or weak areas can be remarkably reduced.

The present application relates to the technical field of medical wound dressing, and provides a photothermal responsive Janus fiber dressing as well as a preparation method and application thereof.The Janus fiber dressing is prepared by compounding polycaprolactone / gelatin / curcumin nanofiber and polydopamine modified cotton gauze.The dressing has photothermal responsiveness and gradient structure, and can realize active exudate drainage / evaporation and synergistic sterilization under near-infrared light irradiation.Meanwhile, local photothermal can trigger on-demand release of curcumin in the PGC layer, play an anti-inflammatory effect, and at the same time, as a colorimetric pH sensor, realize real-time monitoring of the wound in situ.In an infected diabetic mouse model, the dressing exhibits a wound healing effect superior to that of a commercial cotton dressing by reducing inflammation, inhibiting bacterial colonization, promoting collagen deposition and angiogenesis.The Janus fiber dressing integrates exudate management-treatment-monitoring, and provides a new strategy for diabetic wound care.

The invention discloses a double-cavity biliary tract drainage catheter with a monitoring module and a method of the double-cavity biliary tract drainage catheter, and belongs to the technical field of medical instruments.The method includes the steps that S1, an intelligent double-cavity biliary tract drainage system is provided and comprises a drainage catheter with an asymmetric double-cavity structure, the section of the drainage catheter is composed of a main drainage cavity and a monitoring sensing cavity, and the sectional area of the monitoring sensing cavity is smaller than that of the main drainage cavity. A miniature pressure sensor and an ultrasonic transduction piece are integrated on a tip ring part of the drainage catheter, and thermistor arrays are symmetrically arranged on the two sides of a side hole of the drainage catheter. Through the asymmetric double-cavity structural design, the flow resistance of high-viscosity bile is effectively reduced, and through cooperation with an anti-scaling coating wrapping the outer wall, the anti-scaling effect of the high-viscosity bile is improved. The risks of protein adsorption and bacterial colonization are reduced from the physical level, and the occurrence rate of retrograde cholangitis is remarkably reduced.

The disclosure relates to methods and compositions that provide for bacterial populations with increased potential for engraftment into the gut of mammalian systems. Accordingly, aspects of the disclosure relate to a bacterial cell or population of cells that comprise at least one of: i) a heterologous nucleic acid encoding a ECF-type sigma factor of the family identified above based on the structure and sequence of cognate anti-sigma factor, or a functional fragment thereof; ii) deletion of a functional ECF-type-associated anti-sigma factor; or iii) a heterologous nucleic acid encoding a ECF-type sigma factor-induced gene and / or an O-antigen inducing gene.