12 results about "Aids patients" patented technology

The invention discloses an AIDS treatment compliance intelligent image monitoring and intervention system and method, and belongs to the technical field of artificial intelligence and image processing, and the system comprises an image collection module, an image preprocessing module, a feature extraction module, an image sequence modeling module, a compliance evaluation module, a reminding strategy module and a notification execution module. The core innovation of the system lies in the image sequence modeling module, the module maps continuously collected medicine images to Riemannian manifold to form a medicine taking behavior track, accurate judgment of the medicine taking behavior is achieved through geodesic distance calculation and curvature tensor analysis, and the system particularly has outstanding advantages in the aspect of identifying false medicine taking behaviors, and has good application prospects. The medicine taking behavior recognition accuracy is improved to 93.1%, the false medicine taking behavior detection rate reaches 95.4%, and clinical application proves that the treatment compliance of AIDS patients can be improved to 91.6% from 72.3% by using the system, the treatment effect is remarkably improved, and the development of drug resistance is reduced.

The invention relates to an exemption treatment system for an AIDS patient, and the system comprises a patient information input module which is used for inputting basic information of the patient; the patient evaluation module is used for evaluating psychological, physical and social indexes of the patient according to the input information; the providing and processing module for formulating or adjusting a patient treatment scheme is connected with the patient evaluation module; and the AIDS patient intervention rehabilitation processing module is connected with the processing module for formulating or adjusting the patient psychological treatment scheme. The invention further relates to a corresponding method and device, a processor and a storage medium thereof. By adopting the system, the method and the device for the exemption treatment system evaluation and rehabilitation management for the AIDS patient, the processor and the storage medium thereof, an individualized, intelligent and convenient psychological treatment scheme is formulated and provided for the AIDS patient; therefore, psychological-physiological-social rehabilitation of AIDS patients can be realized to the greatest extent.

The application of the deubiquitinase to the immune reconstitution incomplete prediction target of the AIDS patient comprises the following steps: identifying that the ubiquitinase is YOD1 and has obvious interaction with HIV virus protein Nef; identifying that the YOD1 stabilizes the HIV auxiliary protein Nef through the protein level instead of the RNA level; identifying that the YOD1 can prolong the half-life period of the HIV auxiliary protein Nef; the YOD1 is identified to enhance the expression level of Nef in virus particles of an HIV NL4-3 clone strain by reducing the ubiquitination of the Nef protein of HIV-1 (Human Immunodeficiency Virus 1) and influence the ubiquitination of the K6 site of the Nef protein; identifying that YOD1 inhibits ubiquitination of Nef protein and stabilizes the Nef protein; yOD1 is identified to be in positive correlation with Nef under the HIV infection condition, and the positive correlation is increased along with the increase of the infection dose or the infection time; it is identified that YOD1 promotes virus replication by stabilizing the Nef protein level and aggravates loss of CD4 + T cells, and the expression level of YOD1 is in positive correlation with immune imperfection of an HIV-1 infected person; it is identified that the vitamin C can effectively lower the expression level of YOD1 and Nef protein, and then the virus virulence is reduced.

This utility model relates to the field of medical device technology, specifically to a device for preventing pressure on endotracheal tubes in prone ventilation patients. It includes a fixing base and an endotracheal tube. The fixing base has a groove inside, and a positioning ring is fixedly connected to the rear end of the fixing base. The endotracheal tube is slidably connected within the positioning ring, and a linkage component is provided on the outer side of the fixing base. This utility model, through the linkage component, allows the endotracheal tube to move at any angle, making it more flexible and effectively preventing the tube from folding due to head movement during patient movement. This facilitates oxygen supply and suctioning, aids patient recovery, and solves the problem that existing endotracheal tubes are prone to folding in prone patients due to their specific posture, affecting oxygen delivery. The sliding block moves along a groove, further improving the flexibility of the endotracheal tube.

The invention relates to the technical field of antibodies, in particular to an LAM polyclonal antibody as well as a preparation method and application thereof. The polyclonal antibody designed by the invention is wide in detection range and is still suitable for non-AIDS patients; the kit can specifically recognize LAM of mycobacteria, including LAM of mycobacterium tuberculosis and LAM of slowly-growing and rapidly-growing nontuberculous mycobacteria (NTM), and can be used for detecting tuberculosis and nontuberculous mycobacterium diseases. The antibody combination provided by the invention has high sensitivity and high specificity, can be used for qualitative and quantitative analysis of LAM antigens in various types of samples (especially body fluid samples), and is helpful for improving the accuracy of detection results.

This application relates to the biomedical field and discloses a predictive model and validation method for ART virological failure in HIV / AIDS patients. The model construction method includes the following steps: S1, collecting clinical data from HIV or AIDS patients; S2, performing multiple imputation processing on the clinical data to generate multiple datasets; S3, using a stepwise regression method to screen predictive factors in each dataset; S4, synthesizing the datasets to determine the final predictive factors; S5, establishing a virological failure prediction model based on the final predictive factors. The predictive model constructed by this invention can serve as an effective tool for predicting the risk of ART virological failure in HIV or AIDS patients in clinical practice. The application of this model helps improve treatment effectiveness, optimize resource allocation, and ultimately improve patient treatment outcomes. Furthermore, by continuously collecting new patient data and re-evaluating model performance, the accuracy and practicality of the model can be further improved.

The application provides a new use of soluble CD73 (sCD73) as a marker for predicting the immune reconstruction of HIV / AIDS patients after antiviral treatment, and belongs to the technical field of biological medicine. The sCD73 can be used for predicting the reconstruction of the immune system of HIV / AIDS patients after antiviral treatment, and has the advantages of rapid detection, accuracy, low cost and the like, and has a wide application prospect.

The invention discloses a method and a kit for detecting single-cell-level HIV-1 (human immunodeficiency virus-1) positive cells based on micro-droplet digital PCR (polymerase chain reaction). The invention provides a complete set of primers and probes. The complete set of primers and probes comprises an LTR primer pair, an LTR probe, an Env primer pair and an Env probe, the LTR primer pair is composed of a single-stranded DNA molecule as shown in a sequence 1 and a single-stranded DNA molecule as shown in a sequence 2; the nucleotide sequence of the LTR probe is a sequence 3; the Env primer pair is composed of a single-stranded DNA molecule as shown in a sequence 4 and a single-stranded DNA molecule as shown in a sequence 5; and the nucleotide sequence of the Env probe is a sequence 6. The primer and probe combination can detect almost all HIV-1 subtypes and is suitable for detection of clinical samples, the detection method for quantifying HIV-1 positive cells through ddPCR can conduct high-precision quantification on the virus level in the body of an AIDS patient after antiviral treatment, and the antiviral treatment effect is monitored more accurately.

The invention relates to the technical field of computers, discloses an internet-of-things-driven AIDS patient remote follow-up monitoring method and system, and aims to solve the problems that in the prior art, multi-source data fusion is insufficient, risk prediction precision is low, a model lacks self-adaptive ability, and intervention is disjointed from clinic. The method comprises the following steps: collecting physiological, medication and environmental data in real time through an Internet of Things terminal; cleaning, alignment and feature extraction are carried out through an edge gateway; the method comprises the following steps: fusing an electronic medical record at a cloud end, performing dynamic modeling by utilizing a hybrid model of a time sequence convolutional network and a long-short-term memory network, and generating an individualized health risk score through a cross-modal attention mechanism; and matching the three-level intervention rule base based on the score, and dynamically pushing follow-up or medical instructions. According to the technical scheme, high-precision risk early warning, minute-level continuous monitoring, low-delay response and personalized closed-loop intervention can be achieved, and the follow-up compliance rate and the clinical intervention efficiency are remarkably improved.

The present application relates to the technical field of traditional Chinese medicine preparation, and specifically discloses a traditional Chinese medicine composition for treating dyslipidemia of HIV / AIDS patients, which is composed of the following raw materials in parts by weight: radix codonopsis 8-16 parts, white atractylodes fried with bran 6-12 parts, poria 6-12 parts, prepared licorice 3-8 parts, costus 3-7 parts, amomum 2-6 parts, pinellia 4-9 parts, magnolia officinalis 4-10 parts, immature bitter orange 5-11 parts, divinum 5-10 parts, monascus 6-12 parts, white peony root 6-12 parts, goldthread 2-5 parts, cassia twig 3-8 parts. The present application develops a traditional Chinese medicine composition for treating dyslipidemia of HIV / AIDS patients according to the complex pathogenesis of HIV / AIDS patients, i.e., "spleen deficiency as the root, phlegm and blood stasis as the branch, and cold and heat mixed together", realizes overall regulation and precise intervention through specific compatibility of medicinal materials, effectively controls the blood lipid of HIV / AIDS patients, effectively reduces the blood lipid level without interfering with the efficacy of ART, and avoids adverse reactions caused by statins. The preparation process is simple, and the present application is safe and effective with few side effects.

The present application relates to a kind of determination methods of the concentration of conazepam in blood plasma, belong to the technical field of drug concentration analysis.The determination method uses the way of adding internal standard working solution to the blood plasma sample to be measured to process clinical sample, the concentration of conazepam in blood plasma is determined using ultra-high performance liquid chromatography-tandem mass spectrometry, the clinical specific population including AIDS patients, chronic hepatitis patients and liver transplant patients.The determination method of the concentration of conazepam in blood plasma provided by the present application combines the diagnosis and treatment needs of clinical therapeutic drug monitoring, systematically completes the method linear range, sample stability verification, and special plasma matrix effect of chronic hepatitis, AIDS, liver transplant patients is investigated, significantly improves the detection accuracy and clinical adaptability, can accurately support the individualized dosing of conazepam and therapeutic drug monitoring, and the clinical popularization value is excellent.

The invention relates to a method for detecting immune reconstruction of AIDS patients through full-spectrum flow cytometry, belongs to the technical field of immune cell detection, and is used for detecting various immune cells of peripheral blood mononuclear cells of healthy individuals, immune responders and immune non-responders on the basis of full-spectrum flow cytometry. The method comprises the following steps: carrying out antibody staining labeled by 28 fluorescein in a cell sample, distinguishing 25 immune cell subgroups including NK cells, B cells and T cells, detecting immune function markers of the immune cell subgroups, and analyzing the quantity proportion and functional states of the immune cell subgroups of HIV patients with different immune reconstruction degrees.