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3 results about "Immune compromised" patented technology
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Immune compromise, also referred to as immunocompromise or immunosuppression, is a condition in which the immune system does not work as well as it does in normal healthy workers. Immune compromised personnel are at higher risk of illness and/or more serious side effects of illness caused by an infectious disease.
AAVR knockout mouse in combination with human liver chimerism and methods of use and production of the same
PendingUS20260007122A1Compounds screening/testingCell receptors/surface-antigens/surface-determinantsImmune compromisedKnockout animal
The present disclosure provides an immunodeficient or immune-impaired chimeric non-human animal with a deletion or impairment of adeno-associated virus receptor (AAVR), comprising human hepatocytes, methods for preparing the chimeric non-human animal comprising human hepatocytes and methods of utilizing the chimeric non-human animal comprising human hepatocytes to evaluate transduction efficiency of adeno-associated viruses (AAV), and determine mechanism of inhibition / modification of AAV transduction in human hepatocytes.
Owner:AVACHROME INC
Method for diagnosing immunocompromise in workers exposed to mixed aerosols containing crystalline silicon dioxide from 10 to 70% and metals in solid phase
FIELD: occupational medicine.SUBSTANCE: used to diagnose immunocompromise in workers exposed to mixed aerosols containing crystalline silicon dioxide from 10 to 70% and metals in the solid phase. Samples of venous blood and smears from the mucous membrane of the pharynx are taken. In the presence of Streptococcus pneumoniae DNA in scrapings from the mucous membrane of the pharynx and with the level of immunoglobulin M in the blood serum≤ 1.7 g / l is used to diagnose immunocompromise in workers exposed to mixed aerosols containing crystalline silicon dioxide from 10 to 70% and metals in the solid phase.EFFECT: method provides the possibility of selecting immunocompromised workers exposed to industrial mixed aerosols for priority vaccination against pneumococcal infection at the stage of periodic medical examination, by determining the level of immunoglobulin M in the blood serum and Streptococcus pneumoniae DNA in swabs from the mucous membrane of the pharynx.1 cl, 1 tbl, 1 ex
Owner:FEDERALNOE BYUDZHETNOE UCHREZHDENIE NAUKI EKATERINBURGSKIJ MEDITSINSKIJ NAUCHNYJ TSENTR PROFILAKTIKI I OKHRANY ZDOROVYA RABOCHIKH PROMPREDPRIYATIJ FEDERALNOJ SLUZHBY PO NADZORU V SFERE ZASHCHITY PRAV POTREBITELEJ I BLAGOPOLUCHIYA CHELOVEKA FBUN EMNTS POZRPP ROSPOTREBNADZORA
Systems to produce B cells genetically modified to express selected antibodies
Systems and methods to genetically modify B cells to express selected antibodies are described. The systems and methods can be used to: obviate the need for classical vaccinations; provide protection against infectious agents for which no vaccinations are currently available; provide protection against infectious agents when patients are otherwise immune-suppressed; and / or provide a benefit provided by a therapeutic antibody, such as in the treatment of autoimmune disorders.
Owner:FRED HUTCHINSON CANCER CENT