255 results about "Galactooligosaccharide" patented technology

The invention provides an antioxidant enzyme-containing composition and a preparation method thereof, and relates to the technical field of enteritis treatment. The preparation method comprises the following steps: S1, collecting various component materials for preparing the antioxidant enzyme-containing composition: collecting various raw materials for preparing glucan, fructo-oligosaccharide, galactooligosaccharide, superoxide dismutase, vitamin C, bunge cherry seed powder, cassia seed powder, turmeric, sorbitol, hydroxypropyl methyl cellulose, silicon dioxide and magnesium stearate; according to the invention, a matched powder bagging machine is adopted to realize full-automatic unattended operation to automatically complete the large bag filling and sealing step in the steps S4-S10, vacuumizing is performed firstly and then sealing is performed, and the storage space is compressed by vacuumizing, so that the condition that the bag is expanded and broken by internal air pressure in the transfer and storage process is not easy to cause; in the bag sealing process, the phenomena of high hot melting efficiency and high sealing speed are achieved by adopting a bag strip guiding and rolling hot melting mode.

The invention discloses a composition for improving bone density and application thereof, and belongs to the technical field of food. According to the invention, the 1, 3-dioleic acid-2-palmitin, the osteopontin and the oligosaccharide are compounded for use, and the components interact to promote mutual absorption and utilization, so that the growth and development of bones in the growth period of infants are improved, the mineral content and the bone mineral density of the bones are increased, the health of the bones is promoted, and the composition is safe and free of side effects. And by optimizing the variety of the oligosaccharide, the compound use of the galactooligosaccharide and the 2 '-fucosyllactose is found to be capable of better improving the growth and development of bones in the growth period of the infants.

The invention discloses a composition for promoting animal bifidobacterium subsp. Lactis to proliferate in intestinal tracts and application thereof, and belongs to the technical field of probiotics, the composition comprises a prebiotic composition and animal bifidobacterium subsp. Lactis, wherein the prebiotic composition is prepared from at least three of mannose oligomer, cotton seed oligosaccharide, isomaltooligosaccharide and galactooligosaccharide; the number of viable bacteria of the bifidobacterium animalis subsp. Lactis added in each gram of the prebiotic composition is 106-1012. According to the invention, at least three of the mannan-oligosaccharide, the cotton seed oligosaccharide, the isomaltooligosacharide and the galactooligosaccharide are compounded, so that the probiotic effect of the probiotics is coordinated and enhanced.

The invention provides a soluble dietary fiber composition. The soluble dietary fiber composition comprises galactomannan, kelp dietary fibers, oat beta glucan, galactooligosaccharide, polydextrose, stachyose and xanthophyll. The invention also provides application of the soluble dietary fiber composition in functional food or constipation treatment medicines.

The invention provides a milk powder composition containing breast milk oligosaccharide and easy to digest and absorb. The milk powder composition comprises the breast milk oligosaccharide, OPN, galactooligosaccharide, lactoferrin, alpha-whey protein, multivitamins, lactose, vegetable oil and compound minerals, wherein the weight ratio of the lactoferrin to the OPN to the breast milk oligosaccharide to the galactooligosaccharide is 1: (2-4): (2-50): (4-100). The composition can effectively recover and improve the intestinal barrier function caused by inflammatory factors, can be well absorbed by infants with poor digestion and absorption functions, reduces diarrhea and promotes skeletal development.

The invention discloses a prebiotic composition capable of proliferating bifidobacterium and application of the prebiotic composition. The prebiotic composition comprises polydextrose, isomaltooligosacharide and galactooligosaccharide. Wherein the mass ratio of the polydextrose to the isomaltooligosacharide to the galactooligosaccharide is (0-2): (3-5): (4-5). The prebiotic composition provided by the invention can increase the content of total bifidobacteria in intestinal tracts, especially can specifically proliferate bifidobacteria longum and bifidobacteria breve, and can accurately regulate and control intestinal flora, thereby accurately intervening in host health.

The invention discloses a composition for proliferating animal bifidobacterium subsp. Lactis and application of the composition, and belongs to the field of probiotics, and the composition comprises a prebiotic composition and a traditional Chinese medicine composition, wherein the mass ratio of the prebiotic composition to the traditional Chinese medicine composition is (5-10): (1-5); the prebiotic composition comprises at least three of mannose oligomer, cotton seed oligosaccharide, isomaltooligosaccharide and galactooligosaccharide; the traditional Chinese medicine composition comprises a Chinese prescription and ginseng powder, and the Chinese prescription comprises at least two of astragalus membranaceus, liquorice and ginger and cinnamon. The composition capable of efficiently proliferating the animal bifidobacterium subsp.lactis is screened out, the proliferation speed and the proliferation amount are both considered, the probiotic effect of probiotics is enhanced, the composition can help proliferation of the animal bifidobacterium subsp.lactis, the advantages of rapidness and high growth are both achieved, and more health effects are achieved.

The invention discloses a composition for regulating sleep rhythm homeostasis as well as a preparation method and application thereof. The composition for regulating the sleep rhythm homeostasis is prepared from the following components in percentage by weight: 5 to 18 percent of polydextrose, 9 to 15 percent of galactooligosaccharide, 1 to 10 percent of inulin, 0.4 to 2 percent of gamma-aminobutyric acid, 0.8 to 2.2 percent of L-theanine, 0.1 to 3.5 percent of magnesium citrate, 2 to 21 percent of semen ziziphi spinosae extract, 1 to 10 percent of poria cocos extract, 0.5 to 2 percent of pericarpium citri reticulatae extract, 0.3 to 1 percent of liquorice root extract and 15 to 40 percent of maltodextrin. 5-18% of coconut oil powder MCTs, and 0.5-2% of a lily extract. According to the application, a magnesium MCTs shell-core structure is delivered by maltodextrin to form a mitochondrial piezoelectric engine so as to improve prebiotics, promote flora metabolism efficiency and energy supply feedback, activate intestinal pheochromophilic cells and improve SLC6A4 gene expression so as to improve synthesis of 5-hydroxytryptamine in the brain and activate GABA energy neurons; meanwhile, through the spina date seed and poria cocos quantum dots and a pericarpium citri reticulatae and liquorice pi-pi stacking network, the blood-brain barrier penetration rate is greatly increased, and hypothalamic CRH release is adjusted.

The invention relates to the technical field of functional food, in particular to immune regulation type prebiotic syrup with synergy of galactomannan. The active components of the composite solid beverage are prepared from the following raw materials in percentage by weight: 20%-35% of fructo-oligosaccharide, 10%-18% of galactooligosaccharide, 8%-15% of stachyose, 3%-7% of xylooligosaccharide, 5%-12% of lactitol, 5%-10% of galactomannan, 2%-5% of yeast beta-glucan and 1%-3% of N-acetylglucosamine. The composition further comprises 4-8% of inulin and 3-6% of resistant dextrin as a matrix filling and slow-release carrier, and the sum of the weight percentages of all the active ingredients and the carrier is 100%. By remodeling intestinal microecology and inhibiting inflammation pathways, the intestinal inflammation state can be remarkably improved, expression of intestinal mucosa tight junction protein is promoted, and an innovative solution is provided for people suffering from chronic bowel diseases and immune imbalance.

The invention relates to the technical field of prebiotics preparation, and discloses a preparation method of prebiotics applied to reproduced areca catechu, and the preparation method comprises the following steps: carrying out enzyme catalysis reaction on sucrose by adopting fructosyl transferase to prepare fructo-oligosaccharide; according to the method, beta-galactosidase is adopted to carry out enzyme catalysis reaction on lactose, so that galactooligosaccharide is prepared; respectively carrying out decoloration, ion exchange, nanofiltration concentration and spray drying on the candy oligosaccharide and the galactooligosaccharide to obtain powder; the method comprises the following steps: mixing fructo-oligosaccharide powder and galactooligosaccharide powder according to a ratio, and uniformly distributing the mixture in a reproduced areca-nut matrix by adopting a spray-drying blending or low-temperature vacuum mixing mode to form a functional reproduced areca-nut product; according to the invention, low-temperature drying is carried out on the product after blending or vacuum mixing, so that the prebiotic areca nuts are released along with saliva in the chewing process, and are selectively utilized by bifidobacteria and lactic acid bacteria after entering the stomach and intestine, thereby achieving the purposes of regulating intestinal flora and improving the health-care function.

The invention discloses a preparation method of soybean milk powder for promoting immune regulation, and belongs to the technical field of soybean product processing. Performing biological enzymolysis; modifying soybean protein; compounding functional components; and preparing the microcapsule. An ultrasonic-enzyme composite extraction technology is applied, and the enrichment rate of components with immunocompetence is increased. According to the method, the Maillard reaction is performed on the soybean protein and the polysaccharide by utilizing an ultrasonic-assisted heating technology, so that the emulsifying characteristic of the soybean protein isolate is improved, and the immunoregulation promoting performance of the soybean protein isolate is greatly improved. According to the invention, through a microcapsule embedding technology, glycosylated soybean protein is wrapped in the particles by a wall material formed by galactooligosaccharide and resistant dextrin, the stability and bioavailability are improved, the microencapsulation efficiency is greater than 95%, and the immunoregulation promotion performance of the microencapsulated soybean protein is effectively exerted. By adopting spray drying, inactivation of immune active components caused by high temperature is avoided.

The invention discloses a beta-galactosidase mutant derived from bifidobacterium bifidum and application thereof, and belongs to the technical field of enzyme engineering. The invention aims to improve the GOS synthesis yield and shorten the treatment time. The invention provides a beta-galactosidase mutant derived from bifidobacterium, and the mutant is obtained by mutating a 531 site, a 682 site, a 747 site or a 710 site by taking SEQ ID No.1 as a starting sequence. The glucoside conversion rate of the mutant W710F after reacting in a 350g / L lactose system for 5 hours reaches 45.90%, and is increased by 53.87% compared with that of a wild type. The beta-galactosidase mutant has the excellent properties of high catalytic efficiency and high yield of galactooligosaccharide, the cost of prebiotics is reduced, the conversion efficiency of producing galactooligosaccharide by using the beta-galactosidase mutant is improved, and the beta-galactosidase mutant has great industrial production and application potential and economic value.

The invention relates to the technical field of animal feed, in particular to a high-efficiency growth-promoting pig compound additive and a preparation method thereof. The high-efficiency growth-promoting pig compound additive is prepared from the following raw materials in parts by weight: 5-8 parts of bacillus subtilis; 3 to 5 parts of bacillus licheniformis; 4 to 6 parts of fructo-oligosaccharide; 3 to 5 parts of galactooligosaccharide; 8 to 12 parts of yeast extract; 2-4 parts of a yucca extract; 1 to 2 parts of cellulase; 1-2 parts of acid protease; 0.5 to 1.5 parts of curcumin; 0.3 to 0.8 part of tea polyphenol; 1-3 parts of taurine; and 2 to 4 parts of glycine chelated zinc. According to the efficient growth-promoting pig compound additive and the preparation method thereof, multi-dimensional collaborative optimization is adopted, probiotics and prebiotics are combined, colonization of beneficial bacteria in intestinal tracts is promoted, metabolic active substances are generated, antibiotic dependence is replaced, organic microelements are used for replacing high-dose inorganic zinc, and the risk of environment residues is reduced; the natural anti-inflammatory component and the light stabilizer reduce oxidative stress and photosensitive toxicity, are significantly superior to the traditional scheme, and have both environmental friendliness and cost effectiveness.

The invention belongs to the technical field of biochemistry, and particularly relates to a probiotic composition for relieving depression as well as a preparation method and application of the probiotic composition. The probiotic composition is prepared from bacillus cecum, lactobacillus reuteri and an oligosaccharide composition; wherein the viable count of the bacillus cecum and the lactobacillus reuteri is 10 < 9 >-10 < 11 > CFU / g; the oligosaccharide composition is prepared by compounding polydextrose, fructo-oligosaccharide and galactooligosaccharide according to an optimized weight ratio. According to the invention, the oligosaccharide composition is cooperated with the probiotics to play a curative effect, so that the proliferation effect of the bacteroides cecum and the lactobacillus reuteri in the intestinal tract is improved, and the balance of the probiotics in the intestinal tract is regulated. Detection results of behavioristics and physiological indexes of mice show that the depression-like behaviors of the mice are remarkably reduced under the action of the composition, and various biochemical indexes are remarkably improved; the composition has a certain improvement effect on depressive mood.

The invention provides coconut oil essence hand cream and a preparation method thereof. The hand cream is prepared from the following raw materials in parts by weight: 18 to 24 parts of coconut oil essence, 12 to 15 parts of compound tremella extract, 3 to 6 parts of fig fruit extract, 7 to 10 parts of grape seed oil, 6 to 9 parts of olive fruit oil, 4 to 7 parts of squalane, 5 to 8 parts of fucoidin, 3 to 6 parts of galactooligosaccharide, 2 to 4 parts of dipotassium glycyrrhizinate, 10 to 14 parts of propylene glycol, 12 to 15 parts of glycerol, 0.01 to 0.05 part of preservative, 10 to 14 parts of sucrose fatty acid ester, 13 to 17 parts of sorbitan olivate, 0.2 to 0.6 part of essence and 140 to 180 parts of water. Through the mutual synergistic effect of the raw materials such as the coconut oil essence, the composite tremella extract, the fig extract, the grape seed oil, the olive fruit oil, the squalane, the fucoidin and the galactooligosaccharide, moisture of hand skin can be effectively locked, a protective layer is formed on the surface layer of the skin, loss of moisture of the hand skin is reduced, and the hand cream has a good hand moisturizing effect. Therefore, the hand skin is kept in a moisturized state, and the problems of skin dryness, desquamation, cracking and the like are effectively reduced.

The invention discloses a preparation method and application of a biological enzyme immobilization carrier, and the preparation method comprises the following steps: S1, soaking dried calcium pectin powder in a pyrrole monomer aqueous solution, so that a pyrrole monomer uniformly permeates into calcium pectin gel particles along with water; s2, soaking the hydrogel obtained in the step S1 in a FeCl3 aqueous solution, and cross-linking the pyrrole monomer into polypyrrole; s3, the gel particles are put into a chitosan solution, the pH value of the chitosan solution is 4.0-4.5, stirring is conducted, chitosan is enriched on the surfaces of the calcium pectin gel particles to form a polyelectrolyte compound, and the chitosan is electrostatically adsorbed on the surfaces of the gel particles to obtain a biological enzyme fixed carrier with a gel core structure; according to the biological enzyme carrier with the gel solid structure, the characteristic that water in gel in the carrier does not flow is utilized, a substrate in reaction liquid is effectively enriched on the surface of the enzyme carrier, contact between enzyme and the substrate is improved, and the conversion efficiency of galactooligosaccharide is improved.

The invention relates to a beta-galactosidase mutant with improved thermal stability and pH stability, and belongs to the technical field of enzyme engineering. The beta-galactosidase derived from Kluyveromyces lactis is subjected to molecular modification, a potential mutation site is determined by using an alanine scanning strategy, beta-galactosidase mutants Pro433Ala and Asp441Ala of which the thermal stability and the pH stability are simultaneously improved are obtained through site-directed mutagenesis screening, the catalytic efficiency of the mutants is improved to 1.03-1.18 times compared with that of the mutants before optimization, and the beta-galactosidase mutant can be used for preparing beta-galactosidase. Wherein the maximum half-life period of the mutant Asp441Ala under the condition of 50 DEG C reaches 91.5 minutes and is increased by 213.4% compared with that of a wild type, the problems of poor catalytic thermal stability and poor pH stability of beta-galactosidase in the prior art are solved, and a brand-new tool is provided for obtaining galactooligosaccharide by using beta-galactosidase to hydrolyze lactose.

The invention relates to the field of anti-allergic compositions, and discloses an immunoregulation anti-allergic compound powder based on non-active yeast and probiotics, and the immunoregulation anti-allergic compound powder comprises the following components in parts by mass: 15-30 parts of non-active yeast powder, 10-25 parts of a probiotic composition, 40-55 parts of a prebiotic composition, 4-6 parts of fucoidin, 0.5-1.5 parts of N-acetylneuraminic acid, and 5-10 parts of an auxiliary material; wherein the prebiotic composition is prepared from resistant dextrin, stachyose, fructo-oligosaccharide and galactooligosaccharide; the auxiliary materials comprise at least two of anhydrous dextrose, acerola cherry powder, elderberry powder, sorbitol and yeast beta-glucan. Through the coupling design of low-temperature mixing and a step-by-step embedding process, the mobility of the powder is maintained, and meanwhile, the activity of thermosensitive components is kept. Compared with a conventional high-temperature mixing or disordered adding process, the problems of component damage and function loss caused by a heat effect or mechanical shearing are solved.

The invention relates to the technical field of functional food preparation, and discloses solid soft sweets capable of remarkably relieving asthenopia and a preparation method of the solid soft sweets, and every 100 parts by mass of the soft sweets comprise the following components: 5.8-6.2 parts of lutein ester microcapsules, the wall material of which is starch octenyl succinate with the substitution degree of 0.02-0.04; the emulsifier is lecithin of which the purity is greater than or equal to 90%, and the particle size lt of the emulsifier is 1t; the particle size is 200 nm; 75 to 85 parts of blueberry anthocyanin-VC compound freeze-dried powder; 18 to 22 parts of lycium barbarum polysaccharide; 45 to 55 parts of galactooligosaccharide; 8 to 12 parts of medium chain triglyceride; and a colloid base material. Through collaborative design of a hydrophobic modified wall material and a gradient mixing process, a multi-level protection network of active ingredients is constructed, so that the retention rate of fat-soluble nutrients in the processing and storage period is increased to 90% or above.

The invention provides freeze-dried pet food capable of improving intestinal functions of pets and a preparation method of the freeze-dried pet food. Firstly, lecithin and beta-sitosterol are used for constructing lipidosome embedded compound bacteria, and then lactoferrin is combined with embedded compound enzyme to form microspheres; chitosan oligosaccharide is used for connecting compound bacteria liposome and compound enzyme microspheres, the chitosan oligosaccharide is loaded in an alginate gel network to prepare a compound microcapsule, finally raw materials such as yoghourt, camel milk, milk mineral salt and galactooligosaccharide are mixed, and the freeze-dried pet food is prepared through vacuum freeze drying. The sodium alginate composite microcapsule prepared by the invention can greatly improve the stability of probiotics and enzymes, ensure the activity of the probiotics and the enzymes, and improve the palatability of pets to daily ration, increase the food consumption of the pets, promote the digestion and absorption of nutrient substances by the intestinal tracts of the pets and improve the immunity of the pets by virtue of targeted release of the intestinal tracts and synergistic effect of the prebiotics. The intestinal function of the pet is improved, and an efficient and safe solution is provided for the intestinal health of the pet.

The invention relates to the technical field of pharmaceutical compositions, and particularly discloses a proteolipid composite supplement with synergistic hangover alleviating and liver protecting functions and a preparation method thereof. The health-care food comprises the following components in percentage by mass: 10-25% of a Pu'er tea extract, 15-30% of glucose syrup, 5-15% of a hovenia acerba extract, 5-15% of a radix puerariae extract, 8-20% of corn peptide, 5-15% of oyster peptide, 3-10% of earthworm peptide, 1-5% of malic acid, 2-8% of multivitamins, 1-5% of an electrolyte compound, 3-10% of prebiotic fibers and 0.5-3% of gamma-aminobutyric acid. The compound vitamins comprise B1, B2, B6, B12, folic acid and vitamin C; the electrolyte compound is a nanoscale electrolyte compound and is an organic chelate containing potassium, magnesium and zinc; the prebiotic fiber is prepared by compounding galactooligosaccharide and resistant dextrin; through compounding design of active peptide components, plant active ingredients and functional factors, the active peptide improves the activity of key enzymes in ethanol metabolism in a targeted manner, and alcohol decomposition is accelerated.

The invention relates to the technical field of dairy product processing, in particular to high-protein native-dietary-fiber-rich zero-lactose milk and a preparation method thereof.The method comprises the following steps that 1, raw milk is treated through a reverse osmosis membrane, and RO penetrating fluid and RO retention fluid are obtained; 2) adding a proper amount of No.1 lactase into the RO retention solution, and hydrolyzing until the lactose concentration is less than or equal to 2g / 100mL and the galactooligosaccharide concentration is more than or equal to 3g / 100mL; 3) pasteurizing the hydrolyzed product, and inactivating the No.1 lactase to obtain a semi-finished product milk liquid containing the native dietary fibers; and 4) adding a proper amount of No.2 lactase into the semi-finished product milk liquid, and hydrolyzing until the lactose concentration is less than 0.5 g / 100mL to obtain the high-protein raw milk rich in native dietary fiber and zero in lactose. According to the method, lactase is subjected to enzymolysis on the premise that the sweetness of milk is not improved, galactooligosaccharide (dietary fiber) is generated in a natural enzymolysis mode, and the natural nutritional value of the product is improved.

The invention discloses zero-lactose milk containing galactooligosaccharide and a preparation method of the zero-lactose milk, and belongs to the technical field of dairy products. By means of the synergistic effect of the immobilized lactase and the acerola cherry powder extract, efficient hydrolysis of lactose is achieved, the lactose content is reduced to 0.1-0.5 g / 100 mL, meanwhile, 1.0-2.5 g / 100 mL of galactooligosaccharide is generated, and the lactase is especially suitable for people with lactose intolerance to drink. The preparation method comprises the following steps: pasteurizing the raw milk at 60-65 DEG C for 20-40 minutes, and then cooling; adding 0.01 to 0.3 percent of immobilized lactase and 0.001 to 0.1 percent of acerola cherry powder extract under the condition of 20 to 50 DEG C, and stirring and reacting for 10 to 60 minutes; then heating at the temperature of 80-120 DEG C for 5-20 minutes for enzyme deactivation; performing ultrasonic homogenization (200 to 500W, 20 to 70kHz, 10min), cooling and filling; and finally, carrying out ultrahigh pressure sterilization for 5 minutes at 500 MPa and 28 DEG C to ensure that the product is sterile. The stability and the repeated utilization rate of the enzyme are improved through the immobilized enzyme technology, and due to the addition of the acerola cherry powder extract, the product is endowed with natural oxidation resistance while the lactose is synergistically hydrolyzed.

The invention relates to the technical field of fermented fruit and vegetable juice, in particular to a compound probiotic fermented fruit and vegetable juice beverage and a preparation method thereof, and the compound probiotic fermented fruit and vegetable juice beverage comprises the following raw materials: apple juice, snow pear juice, carrot juice, a momordica grosvenori extracting solution, compound probiotics, zinc gluconate, citric acid, oat beta-glucan and nano diatomite loaded prebiotics. Nano diatomite is treated through acid pickling and 3-aminopropyltriethoxysilane, then a functional layer with gradient hydrophilic-hydrophobic balance is formed through molecular self-assembly of quercetin (hydrophobic area) and lecithin (hydrophilic head group), the structure is kept stable in fermentation liquor, the hydrophobic end of quercetin is embedded into a probiotic cell membrane phospholipid layer, the hydrophilic end of quercetin is exposed to a liquid phase, and the hydrophobic end of quercetin is embedded into a probiotic cell membrane phospholipid layer. The interface affinity is enhanced; and carboxylated galactooligosaccharide is further grafted, so that the feed has the directional nutritional characteristic of preferential utilization of probiotics.

A use of a nutritional composition in promoting the bidirectional development of the gut and brain via the gut-brain axis. The nutritional composition comprises the following essential components: docosahexaenoic acid, eicosatetraenoic acid, galactooligosaccharide, 1,3-dioleic acid-2-palmitic acid triglyceride, lutein, nucleotide, lactoferrin, casein phosphopeptide, and probiotics. By combining and strengthening multiple functional active components, the gut health and brain cognitive development of the organism can be bidirectionally promoted by means of the microbiota-gut-brain axis. In particular, the present application can promote the regulation of flora in the gut of the organism, increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria related to brain development diseases. The content of butyric acid in the gut can be increased, and the contents of acetic acid and propionic acid are decreased to promote brain and cognitive development.

Lactose-free high-calcium milk having double calcium content and a preparation method therefor. The calcium content in the milk is 200 mg / 100 mL or above; the problem of particle precipitation caused by externally added suspended calcium is solved by using a stabilizer and a phosphate, and the problem of fat floating is solved by optimizing the preparation process; lactase is used to achieve zero lactose and generated galactooligosaccharide promotes high calcium absorption, and the browning degree of milk is also reduced, resulting in less observed fat floating in the milk.

To provide a fast-absorbing granule containing lactic acid bacteria, plant extracts and postbiotics for adjusting intestinal flora, suppressing inflammatory reactions and reducing body weight. [Solution] The present invention comprises a core 11 having an active ingredient containing one or a combination of the group consisting of spore-forming lactic acid bacteria, Lacticaceabacillus paracasei, Streptococcus thermophilus, Lactobacillus fermentum, Bifidobacterium lactis, Lactobacillus brevis fermentate, Lactobacillus rhamnosus, Lactobacillus complex, fermented pitaya, fermented vegetables, fermented turmeric, fermented roselle, organic vegetable powder, kale extract, broccoli extract, Ganoderma lucidum extract, fructooligosaccharides, galactooligosaccharides, resistant maltodextrin, xylooligosaccharides, and inulin, a flavor correcting layer 12 covering the surface of the core, and a coating layer 13 covering the surface of the flavor correcting layer.

The present invention provides a nutritional composition comprising one or more of vitamin D, polydextrose and galacto-oligosaccharides in combination with a calcium source. The composition has the effect of improving the intestinal mucosal barrier including improving intestinal mucosal permeability, modulating expression of intercellular tight junction proteins, improving intestinal mucosal tissue structure and improving levels of markers of the intestinal mucosal barrier.

Methods and compositions use a galactooligosaccharide (GOS) for increasing absorption of zinc, such as zinc naturally present in ingredients of the composition and / or present in a food product, a meal or a diet, wherein the food product, meal or diet is combined with the composition and / or consumed separately from the composition. Some embodiments are directed to a milk-based composition comprising zinc intrinsically present in the milk, further comprising milk protein, and further comprising a mixture of lactose, glucose, galactose and the galactooligosaccharide (GOS). In some embodiments, the milk-based composition does not contain exogeneous zinc, such that the only zinc in the composition is the zinc intrinsically present in the milk.

The invention relates to the technical field of medicines, in particular to novel application of galactooligosaccharide. The novel use of galactooligosaccharide inhibits the formation of gallstone. Main reagents and materials are galactooligosaccharide; a mouse calculus model feed; the experimental animals are derived from animal varieties and strains: mice, C57BL / 6J; sex: male; week age: 4 week age; the body weight is 16-20 g; the experimental environment is SPF environment feeding, and the feeding condition is that the room temperature is 20-26 DEG C; the relative humidity is 40-70%; automatic illumination is achieved, and light and shade are alternated for 12 h; the drinking water is RO membrane reverse osmosis sterile water; the feeding density is defaulted to be 4 per cage, and the padding is replaced once a week; the experimental process comprises the following steps: starting an experiment after experimental feeding of all mice for one week, and randomly dividing 36 5-week male C57BL / 6J mice into three groups, namely 12 mice in each group. The invention provides a new application of galactooligosaccharide, which can inhibit the formation of gallstone and provides a new thought for preventing the occurrence of the gallstone.