176 results about "Growth hormone" patented technology

The invention relates to the technical field of microorganisms and bio-organic fertilizers, and particularly discloses a bio-organic fertilizer for preventing and treating rhizome diseases of horseradish and application of the bio-organic fertilizer, the bio-organic fertilizer comprises the following components: component A: a bacillus velezensis microbial inoculum with the preservation number of CCTCC NO: M 2022923 and a trichoderma yunnanense microbial inoculum with the preservation number of CCTCC NO: M 2025645; the component B is prepared from soybean meal, vinegar residues, charcoal, wollastonite powder and allicin. The biological organic fertilizer disclosed by the invention can be used for increasing the content of growth hormones such as salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) and phytoalexin as well as the activity of chitinase and beta-1, 3-glucanase of a wasabi root system, and has a relatively good prevention and treatment effect on a black heart disease caused by infection of phoma wabi Yokog and a soft rot disease caused by infection of pectobacterium carotovorum subsp. Carotovorum (Pcc). The biological organic fertilizer disclosed by the invention has a relatively good prevention and treatment effect on the soft rot disease caused by infection of the phoma wabi Yokog and a relatively good prevention and treatment effect on the soft rot disease caused by infection of the phoma wabi subsp. Carotovorum (Pcc).

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

The invention discloses a freeze-drying method of long culture growth hormone, which comprises the following steps: adding a middle plug into a double-cavity clamping bottle, filling the double-cavity clamping bottle with the long culture growth hormone to be freeze-dried, and placing and fixing the double-cavity clamping bottle on a customized freeze-drying bracket; the top plug is placed in the plug pressing assembly so as to be fixed to the bottle opening of the double-cavity clamping type bottle; performing freezing, primary drying and secondary drying on the to-be-freeze-dried long culture growth hormone respectively; the top plug is fixed by the top cover and the bottle opening is sealed; the plug pressing assembly comprises a pressing-in jig and a maintaining jig, the maintaining jig is attached to the outer wall of the bottle opening, and the top plug is placed in the maintaining jig so that the top plug can be fixed to the bottle opening; the press-in jig presses the top plug to be embedded into the bottle opening, and the plug pressing assembly is removed to complete plug pressing. According to the method disclosed by the invention, high-quality freeze-drying parameters and freeze-drying operation can be provided, and the top plug and the top cover are utilized to complete plug pressing and cover sealing of the double-cavity clamping type bottle, so that the obtained growth hormone freeze-drying preparation for the growth culture keeps better appearance and lower moisture.

The invention discloses heavy metal resistant bacillus velezensis as well as a microbial remediation agent and application thereof. Bacillus velezensis DBS01 is screened from heavy metal contaminated soil in Dabaoshan mining areas in Shaoguan City, Guangdong province, is preserved in China Center for Type Culture Collection (CCTCC), has a preservation number of CCTCC M 20252228, not only has resistance to various heavy metals, but also can metabolize and secrete metabolites such as organic acid, cellulase and growth hormone in different growth stages, and can be used for preventing and treating various heavy metals. Multiple functions of curing heavy metals, dissolving phosphorus and potassium, promoting plant growth and the like are realized. According to the method, bacillus velezensis DBS01 is inoculated into a culture medium containing straw, calcium superphosphate, agar and sodium alginate are added, and a mixture containing the bacillus velezensis DBS01 is freeze-dried, so that the heavy metal contaminated soil in the mining area can be efficiently repaired in an environment-friendly manner at low cost, and the ecological function recovery of the soil is effectively promoted.

The invention discloses a high-efficiency phosphate-solubilizing salt-tolerant growth-promoting pseudomonas deliciosa and application thereof, and relates to the technical field of microorganisms, and the technical key points are as follows: the pseudomonas deliciosa HX144 is preserved in China General Microbiological Culture Collection Center (CGMCC) in October 2024, and the preservation number of the pseudomonas deliciosa HX144 is CGMCC NO.32292. The Pseudomonas deliciosa HX144 provided by the invention is high in phosphate solubilizing activity and strong in salt tolerance, the dissolved available phosphorus content of the Pseudomonas deliciosa HX144 is up to 195.75 + / -0.5 mg / L, and the Pseudomonas deliciosa HX144 can tolerate a culture medium environment in which the NaCl concentration is up to 6%. And the strain has a good inhibition effect on plant pathogenic bacteria and human and / or animal pathogenic bacteria. In addition, the strain also has the functions of producing protease, plant growth hormone, siderophore and the like. The strain has a growth promoting effect on wheat crops and can remarkably improve indexes such as plant height, fresh weight and root length of plants. HX144 is an excellent salt-resistant, disease-preventing and growth-promoting pseudomonas strain, and has a wide application prospect in agricultural production.

The present invention provides for the immediate or chronic administration of certain potassium ATP (K ATP ) channel openers, optionally in combination with growth hormone, to subjects to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic, and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration, and methods of dosing K ATP channel openers to achieve these outcomes and to reduce the incidence of adverse effects in treated individuals. Also provided are methods of co-administering K ATP channel openers with other drugs, e.g., in combination with growth hormone, to treat diseases in humans and animals, e.g., Prader-Willi Syndrome (PWS), Smith-Magenis Syndrome (SMS), etc.

The invention relates to the technical field of microbial fermentation, and discloses an agricultural ecological probiotic complex microbial inoculant, which is prepared from the following components in percentage by mass: 30 to 35 weight percent of beneficial microbial inoculant, 20 to 25 weight percent of mineral source potassium fulvate, 15 to 20 weight percent of slow release agent, 10 to 15 weight percent of nano polypeptide fermentation liquor and the balance of carrier, the processing method comprises the following steps: S1, pretreating the raw materials; s2, preparing nano polypeptide fermentation liquor; s3, complex microbial inoculants are compounded; and S4, drying and forming. According to the invention, the mineral source potassium fulvic acid and the nano-polypeptide fermentation liquor are added, so that effective regulation and control of soil micro-ecology are realized; crop growth is promoted through cooperation of multiple strains, growth hormone is secreted through bacillus subtilis and the like, nitrogen is fixed through bacillus amyloliquefaciens, root development is stimulated in cooperation with mineral source potassium fulvic acid, and the plant height, stem diameter and fresh weight of crops are remarkably increased; the particle size of the polypeptide subjected to high-pressure homogenization treatment is 80-120nm, the absorption efficiency is improved by 60%, and a crop disease-resistant signal channel is activated.

The invention discloses a composition for promoting skeletal growth and physical development of children and a preparation method, the composition comprises a plurality of nutrient elements and Chinese herbal medicine components, and the components have the effects of promoting skeletal health, enhancing immunity, improving nutrient absorption, regulating metabolism, improving sleep quality, promoting secretion of growth hormone and the like. The healthy growth of bones and the overall development of a body are jointly promoted.

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

The invention provides a regeneration seedling raising method and system for crop seedlings, and the method comprises the steps: extracting a balance value of growth hormone of an explant in a regeneration culture process from the combination information of a hormone receptor in the regeneration culture process of the explant, and determining a light compensation point of a target crop; performing stepped compensation on the illumination period of the target crop through the light compensation points to obtain compensation characteristics of the illumination period in the regeneration culture process; determining the adjustment interval of the seedling raising temperature of the target crop in each culture stage, and performing light-temperature coupling on the illumination intensity of the target crop according to the adjustment interval of each seedling raising temperature and the compensation characteristic of the illumination period to obtain the coupling characteristic of radiation illumination of the explant of the target crop in each culture stage; and performing staged adjustment on radiation illumination in the regeneration culture process based on each coupling characteristic. Based on the scheme, staged coupling adjustment of radiation illumination in the crop seedling culture process can be achieved.

The invention relates to a low-temperature-resistant azotobacter pseudomonad ZJY-Z1 and application thereof, and belongs to the technical field of microbial agents. The low-temperature-resistant azotobacter pseudomonad ZJY-Z1 disclosed by the invention is preserved in the China General Microbiological Culture Collection Center on February 26, 2025, and the preservation number is CGMCC NO.33670; the low temperature resistant azotobacter pseudomonad ZJY-Z1 has the Latin name of Pseudomonas sp. ZJY-Z1, and the Latin name of the low temperature resistant azotobacter pseudomonad ZJY-Z1 is Pseudomonas sp. ZJY-Z1. The nitrogen-fixing bacterium provided by the invention is resistant to low temperature, has nitrogen fixation capability, can effectively decompose insoluble phosphate, also has certain siderophore production capability and plant growth hormone IAA production capability, and creates more favorable conditions for growth and development of plants.

The invention relates to the technical field of compound fertilizers, in particular to a method for preparing a compound fertilizer rich in bacillus vallismortis and bacillus velezensis and application of the compound fertilizer in rice. The compound fertilizer contains the bacillus vallismortis and the bacillus velezensis, and the two strains are added to enrich soil microbial communities, so that the content of the bacillus vallismortis and the bacillus velezensis can be increased; the biological activity of soil is enhanced, and the balance and stability of a soil ecological system are facilitated; moreover, bacillus vallismortis and bacillus velezensis are used as probiotics and can generate various beneficial substances, such as antibiotics and growth hormones, so that the stress resistance of the plants can be enhanced, and the resistance of the plants to plant diseases and insect pests can be improved; the amino acid composite component is added, so that rich nitrogen sources and other nutrient elements can be provided for soil, absorption and utilization of plants are facilitated, the soil fertility is improved, organic humic acid is converted into organic humic acid through fermentation, and the content of organic matter in the soil can be further increased.

The invention discloses a marine sediment bacillus CK22 and application thereof, and belongs to the field of microorganisms, the strain is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC NO: M20251027. The strain disclosed by the invention has the capabilities of dissolving potassium, dissolving calcium and magnesium and secreting plant growth hormone and cytokinin, particularly has very excellent capability of dissolving magnesium element, is improved by more than 20 times compared with a control group, has excellent comprehensive capability, and can be used for preparing a microbial fertilizer for promoting the growth of crops.

The invention discloses a kudzu vine root seedling raising method. The disclosed method comprises the following steps: sequentially soaking kudzu vine root cuttings in a carbendazim solution and a growth solution; the growth solution is a mixed solution of growth hormone and an aqueous extract of fragrant eupatorium herb; the radix puerariae cuttage branches are lignified kudzu vines with bud nodes; performing cuttage on the soaked cuttings in a rooting medium for culture; the temperature of the culture environment is 26-30 DEG C, and the humidity is 76%-82%; when the cuttings are grown and buds grow to 5cm, applying a nutrient solution to the roots; and continuing to culture until the cutting wood roots and the root hair grows to 10cm to obtain the kudzu vine root seedlings. According to the method, the culture mode, the culture medium and the culture device are improved, so that the root primordium forming number of the cuttings is effectively increased, the rooting rate is increased, and the seedling raising period is shortened.

The invention relates to fermented lactobacillus mucus UP-1 and application thereof to improvement of bone metabolism and promotion of growth, and belongs to the technical field of microorganisms, the classification name of the fermented lactobacillus mucus UP-1 is Limosilicobacterium fermentum UP-1, the preservation unit of the fermented lactobacillus mucus UP-1 is China General Microbiological Culture Collection Center, and the preservation number of the fermented lactobacillus mucus UP-1 is CGMCC No.33076; the preservation time is December 16, 2024. The fermented lactobacillus mucus UP-1 provided by the invention can promote the increase of the body length and the thighbone length diameter by increasing the levels of insulin-like growth factor binding protein-3 (IGFBP3), growth hormone (GH) and insulin-like growth factor (IGF-1) in serum, improve the density of bone trabecula and the level of beneficial metabolite short-chain fatty acid, improve the bone metabolism level, promote the growth of a human body and promote the growth of a human body. The health development of bones is promoted, so that the purposes of promoting growth and development and improving nutrient absorption are achieved, and more scientific diet intervention and precise probiotic development are facilitated.

The invention discloses a siraitia grosvenorii tissue culture seedling ex-vitro rooting method, belongs to the technical field of plant tissue culture, and mainly solves the problems of long rooting time, untidy root development and low transplanting survival rate in the traditional tissue culture seedling ex-vitro rooting technology. The method comprises the following steps: selecting young branches to prepare sterile explants, and performing hormone-induced culture to obtain robust tissue culture seedlings; a growth hormone combination with a specific ratio is adopted in the rooting pre-culture stage; humidity change is controlled through three-stage gradient seedling hardening; the tissue culture seedlings are transplanted to a matrix after being soaked in a 200-350 mg / L ABT rooting solution. The method remarkably shortens the rooting time, improves the root strength, improves the transplanting survival rate, and can be efficiently used for large-scale production of the virus-free seedlings of momordica grosvenori and resist environmental stress such as late spring coldness.

The application discloses application of SbWOX gene and SbBBM gene in corn breeding and a corn genetic transformation method, and relates to a bioengineering technology.The application provides a nucleic acid molecule with co-expression of SbWOX protein gene and SbBBM protein gene, and corresponding gene co-expression vectors and microbial transformants.The application also provides application of the co-expression of the SbWOX gene and the SbBBM gene in the corn genetic transformation method.The application obtains corresponding genes and mutant proteins based on the SbWOX gene and the SbBBM gene of sorghum, the two genes are co-expressed in the corn genetic transformation process, even without adding plant growth hormones in the antibiotic screening medium in the tissue culture process, the plant genetic transformation process can be normally completed, and the transformation efficiency and the regeneration efficiency of the corn can be remarkably improved, the transformation rate reaches 10.42%, and the differentiation rate reaches 32.89%.

The invention provides Rhodococcus qingshengii FJ5 capable of promoting tobacco growth and preventing and treating bacterial wilt and application of the Rhodococcus qingshengii FJ5, and belongs to the technical field of microorganisms. The invention provides a rhodococcus FJ5 strain, and the collection number of the rhodococcus FJ5 strain is CGMCC No.32631. The FJ5 strain is wide in application range, and can well grow under the condition that the temperature is 16-34 DEG C and the pH value is 5.0-8.0. The FJ5 strain promotes early growth of tobaccos and enhances stress resistance by relieving acid-aluminum stress, improving defensive enzyme activity of the tobaccos and improving secretion of growth hormones of the tobaccos and the carbon and nitrogen metabolism level of the tobaccos, and meanwhile, improves fertility of acid soil and prevents and treats bacterial wilt of the tobaccos. The Rhodococcus FJ5 provided by the invention has important development value in high-quality development of tobacco under the condition of rice-tobacco rotation acidified soil, and also has important significance in improvement of stress resistance of plants and biological control of root and stem diseases.

The invention provides an auxin formula for promoting early germination of Chinese cabbage, which is characterized by comprising corn steep liquor, brown sugar, clear water and the like, the final germination rate of Chinese cabbage seeds in clear water and plant auxin is the same, but the third day is the first day of seed germination, and the fourth day is the second day of seed germination. The germination rate of the seeds in the auxin is higher than that in clear water, which indicates that the auxin can stimulate the seeds to break dormancy and germinate in advance.

The invention belongs to the technical field of seedling raising, and particularly relates to a phoebe tenuifolia seed germination and tissue culture rapid propagation method. According to the method for germinating the phoebe davidii seeds, the phoebe davidii seeds are cultured through a 1 / 2 MS culture medium of NAA and AC to obtain aseptic seedlings, the seed germination rate is increased to 95% or above, and the problems that the phoebe davidii seeds are difficult to preserve, the seeding emergence rate is low, and production requirements cannot be met are solved. According to the method, growth hormones with different concentrations and types are added in different stages of adventitious bud induction culture, multiplication culture and rooting culture, so that the adventitious bud induction success rate reaches 90% or above, the multiplication coefficient reaches 6.0 or above, and the rooting rate reaches 96% or above; meanwhile, the problem of easy browning of explant induction culture is solved, and the survival rate and the rapid propagation efficiency of the tissue culture rapid propagation stage are greatly improved.

A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and / or prevention of diseases or disorders in which use of growth hormone is beneficial.

The present invention describes for the first time a method for preventing and / or reversing the phenomenon of premature senescence of skin cells and complex chronic wounds, characterized in that an effective amount of the growth hormone secretagogue peptide GHRP6 is applied. Also object of the present invention is a method for treating cases of complex chronic wounds that have developed primary or secondary refractoriness caused by the development of a cellular senescence process, transforming them from refractory wounds to responsive wounds in the presence of proliferative agents with which they unexpectedly manage to reverse and restart the healing process. Complex chronic wounds include cases of diabetic foot ulcers, venous ulcers, pressure ulcers, radiation ulcers, and other types of chronic wounds that are characterized by refractoriness to all types of treatment. These cases currently have no effective treatments.

The invention discloses a taxodium Zhongshanha lateral branch development related gene ThERF053 as well as an expression protein and application thereof, and belongs to the technical field of plant genetic engineering. The taxodium Zhongshanha ThERF053 gene is obtained through cloning, the nucleotide sequence of the taxodium Zhongshanha ThERF053 gene is shown as SEQ ID NO: 1, and the amino acid sequence of expression protein is shown as SEQ ID NO: 2. The ThERF053 gene is transferred into a model plant poplar, the expression quantity of the ThERF053 transgenic poplar is increased by 980-5100 times, and meanwhile, the content of growth hormone IAA in the transgenic poplar plant is lower than that of a control plant. After growing for 30 days, the phenomenon that lateral branches are obviously increased occurs in the transgenic populus sutchuenensis. The experimental results show that the ThERF053 is a key gene for positively regulating lateral branch development of Taxodium Zhongshanha and has important application value in molecular breeding of Taxodium Zhongshanha and related tree species.

The present invention provides processes for producing a bioengineered lung (BEL) from an acellular lung matrix that has been treated with growth hormones, seeded with primary lung cells, and cultured in a bioreactor. Also provided are BELs and methods of transplanting the BEL into a subject in need of a lung transplant, and methods for using BELs for the study of the lung microbiome and its role in lung development and remodeling.

Disclosed are a compound shown in formula I and racemate, stereoisomer, tautomer, isotopically labeled, nitroxide, solvate, polymorph, metabolite, ester, prodrug or pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same, a preparation method thereof, and a use thereof as a GHSR agonist in the preparation of a drug for the diagnosis, prevention and / or treatment of growth hormone-dependent diseases, the structure of formula I is as follows:

A method for producing a metabolism-activated liver organ, comprising a step for culturing primary hepatocytes or hepatocyte-like cells in a differential medium to obtain a metabolism-activated liver organ, the differential medium is a medium containing a glucocorticoid receptor agonist and one or two selected from the group consisting of a growth hormone receptor agonist and a prolactin receptor agonist.

The invention relates to the technical field of poultry breeding, and particularly discloses an antibiotic-free breeding method for improving the quality of old yard black chickens based on compound plant alternate feeding, and in the growth process of chickens, plant complementary food and basic ration without antibiotics and growth promoting hormone are added for mixed feeding; the adding method of the plant complementary food comprises the following steps: (1) forming a three-day alternating unit according to the sequence of feeding fresh Chinese chives on the first day, feeding fresh wild wormwood on the second day and feeding fresh wild banana trees on the third day, and circularly repeating the mode until the chickens are slaughtered; (2) the adding proportion of the plant complementary food is increased along with the day age of the chickens, and the adding proportion is the mass percentage of the total feeding weight of the day. According to the antibiotic-free breeding method, the specific composite plant feed is adopted for alternate feeding, and the meat flavor, the nutritional value and the health level of the chickens are remarkably improved through functional complementation and time sequence collaboration of plant active ingredients.

The application discloses a transdermal patch special for children with dwarfism, and relates to the technical field of medical treatment, which comprises a patch main body and a needle cylinder, and a fixed plate is fixedly connected to the inside of the patch main body, and the top and the bottom of the fixed plate are penetrated by the needle cylinder; the top of the needle cylinder is provided with a pressing plate, the bottom of the pressing plate is provided with a stand column on the two sides of the needle cylinder, the bottom of the two stand columns is arranged in the inside of the fixed plate and is slidably connected with the fixed plate; the two stand columns are both sleeved with a spring one; the top of the pressing plate is provided with a clamping groove, the bottom of the clamping groove is communicated with the needle cylinder, and a clamping seat is arranged in the clamping groove; the top of the pressing plate is provided with a fence; the two sides of the pressing plate are both provided with a connecting rod, one end of the connecting rod is connected with the pressing plate, and the other end penetrates through the top of the patch main body; the two sides of the patch main body close to the bottom are both provided with a sticking layer; and the two sides of the inside of the patch main body are both provided with a negative pressure sponge layer. The burden of the children with dwarfism is relieved, growth hormone injection treatment is facilitated, and the skin redness and swelling caused after growth hormone injection can be effectively prevented and treated.

The present disclosure relates to a device and a method associated with the device. The device is a portable attachment tool, which can improve mobility, relieve tightness, and increase performance. The device includes an attachment strap, a rigid or semi-rigid protruding feature, a base containing the protruding feature which the attachment strap is connect to, and a locking mechanism on the base that fixes the strap at a certain diameter. The device when applied aids in myofascial release, compression, stability, growth hormone stimulation, lymph and circulation stimulation. With respect to the associated method, the method includes: The user wraps the strap around the affected limb locating the protrusion on the trigger point in the affected region. The strap is pulled snug, and the locking mechanism is engaged. The user then moves the affected limb through easy ranges of motion. The strap may then be removed.

The present invention relates to a customizable injectable solution comprising Human Growth Hormone (HGH), Insulin-like Growth Factor 1 (IGF-1), or a growth hormone secretagogue such as sermorelin or ipamorelin, combined with a blend of nutrients including amino acids, vitamins, electrolytes, functional mushroom extracts, and optionally mushroom mycelium. The solution is delivered via a dual-chamber syringe to preserve component stability, with mixing occurring immediately before administration. The formulation is suitable for subcutaneous, intramuscular, or intravenous injection and may be tailored for muscle growth, cognitive performance, immune support, or neuroregeneration. The invention also contemplates injectable formulations of functional mushrooms alone, as well as alternative delivery methods such as sublingual troches containing GH-inducing peptides, functional mushrooms, and ketamine. This system provides a versatile, bioavailable, and clinically adaptable approach to personalized health optimization.