Compositions and methods for treating or preventing a condition related to
myocardial infarction and infarct expansion, extension, and / or dilation following a
cardiovascular disorder incident (e.g., post-
myocardial infarction) using an effective amount of RRx-001, or a pharmaceutically acceptable salt thereof, are described. In some embodiments, an agent (such as a
statin, an angiotension-converting-
enzyme (ACE) inhibitor,
aspirin,
oxygen, a
nitric oxide donor, a
drug-eluting
stent, an
anticoagulant or antiplatelet therapy, a
phosphodiesterase-5 inhibitor, a
calcium channel blocker, an
angiotensin II receptor blocker (ARB), a
beta blocker, an
aldosterone antagonist, a loop
diuretic, an epigenetic inhibitor, and / or a
nitrite) is administered prior to, concurrently with, or subsequent administering the effective amount of RRx-001, or a pharmaceutically acceptable salt thereof. In some embodiments, the effective amount of RRx-001, or a pharmaceutically acceptable salt thereof, is administered as a composition comprising a
blood product and / or the agent.