30 results about "Bisoprolol" patented technology

The present invention relates to compositions and methods of treating human subjects with a beta-adrenergic receptor blocking agent (“beta-blocker”) provided in a time-sustained-release delivery system. The time-sustained-release drug delivery systems includes at least three populations of beads, where each population of beads includes a beta-blocker. The beads may be selected from immediate-release beads, enteric-release beads, sustained-release beads, and time-sustained-release beads. The beta-blocker may be selected from acebutolol, atenolol, betaxolol, bisoprolol, esmolol, metoprolol, nebivolol, butoxamine, carteolol, carvedilol, labetalol, nadolol, oxprenolol, penbutolol, propranolol, pindolol, sotalol, and timolol. According to presently preferred embodiments, the beta-blocker is propranolol. The dosage forms of the present invention are useful for treating conditions including hypertension, angina pectoris due to coronary atherosclerosis, hypertrophic subaortic stenosis, congestive heart failure, arrhythmias, angina, anxiety, glaucoma, migraines, esophageal varices, alcohol withdrawal syndrome, irregular heartbeat, tachycardia, tremor, and neuroleptic-induced akathisia. They are also useful in the prophylaxis of migraine headaches.

The present invention provides an adhesive composition for patch, containing a rubber elastomer and a tackifier having a weight average molecular weight of 1200-2500, a patch having a support and an adhesive layer containing the composition, which is provided on at least one surface of the support, and a patch preparation having an adhesive layer containing a percutaneously absorbable drug (excluding bisoprolol).

An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisoprolol can be administered continuously into the living body through the skin surface.

It is intended to provide an adhesive preparation which has a low irritation to the skin surface, is excellent in stability of bisoprolol in the preparation and further is capable of continuously administrating a pharmacologically effective amount of bisoprolol to the living body. The adhesive preparation 10 has a support 1 and an adhesive layer 2 which is layered on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, a tackifier and an organic liquid component which is compatible with polyisobutylene and the tackifier. By this, the adhesive preparation having good skin adhesiveness, low skin irritation and reduced pain or adhesive residue at the time of removal from the skin surface can be provided. Further, the adhesive preparation in which the stability of bisoprolol in the adhesive preparation is excellent and the pharmacologically effective amount of bisoprolol can be continuously administrated to the living body through the skin surface is provided.

The present invention pertains to a bisoprolol-containing patch preparation containing a support body and an adhesive layer laminated to one surface of the support body and containing an adhesive agent and free bisoprolol, the stress relaxation percentage of the adhesive layer being 20-90%, and the shear stress of the adhesive layer being 1.0-6.5 N/30 mm width. The bisoprolol-containing patch preparation has suppressed peeling during use, has superior skin adhesiveness, and suppresses skin irritation during delamination. As the adhesive agent, a rubber-based adhesive is preferable, and a polyisobutylene and/or styrene-isoprene-styrene block copolymer is more preferable.

The invention relates to a chiral capillary electrochromatography open tube column based on gold nano modification, a preparation method and an application. The method comprises the steps: bonding a glycidyl methacrylate (GMA) tentacle type polymer coating on the inner wall of a capillary tube; carrying out alkaline ring opening on an epoxy group of GMA under an alkaline condition by utilizing amino of reduced glutathione (GSH), and successfully synthesizing GSH on the capillary tube column; combining gold nanoparticles on the capillary tube column by utilizing the property that sulfydryl of glutathione can generate Au-S bonds with the gold nanoparticles, successfully introducing gold nanoparticles into a capillary stationary phase, and constructing a chiral resolution system based on carboxymethyl-beta-cyclodextrin. Experiments prove that compared with a hollow tubular column which is not modified with gold nanoparticles, the prepared capillary open tube column has the advantages thatthe separation degree and selectivity of three lol drugs (atenolol, sotalol and bisoprolol) are greatly improved, and the purpose of baseline separation is achieved.

The invention relates to a synthesis technology of bisoprolol. The technical scheme of the technology comprises the following steps: (1) using 4-hydroxybenzyl alcohol and isopropoxyethanol to perform the etherification reaction, using strongly acidic styrene type cation exchange resin as catalyst to ensure the alcoholic hydroxyl group etherification reaction to perform under the conditions of room temperature and no solvent; (2) adding sodium hydroxide and epoxychloropropane in the reaction product in the step (1) to ensure phenolic hydroxyl group to perform the etherification reaction; and (3) adding the reaction product in the step (2) in isopropamide, reacting by using boron hydride as catalyst, and preparing bisoprolol. By using the synthesis technology of the invention, the alcoholic hydroxyl group etherification reaction can be performed under the conditions of room temperature and no solvent, the processes of extraction, washing and reduced pressure distillation are simplified; boron hydride is used as catalyst to ensure the amination reaction to perform under a low temperature; the overall yield is increased to above 50%; and the synthesis technology is suitable for industrial production. The solvent used by the technology of the invention can be recycled through distillation; resinic solid acid catalyst can be recycled; and yield and product purity are high.

The present invention relates to a bisoprolol-containing adhesive patch that is provided with: a support body; and an adhesive layer that contains bisoprolol and an adhesive and that is stacked on one surface of the support body. The bisoprolol-containing adhesive patch is characterized by the halogen atom content within the adhesive layer being 0.01-100 weight ppm. The present invention makes it possible to minimize decreases in adhesive strength, discoloration, and the like in a bisoprolol-containing adhesive patch during storage thereof.

A patch preparation includes a support and a pressure-sensitive adhesive layer formed on one surface of the support. The pressure-sensitive adhesive layer includes: (A) a polymer prepared by copolymerizing monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer; (B) a polymer prepared by copolymerizing monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer; and (C) a basic drug, provided that bisoprolol and a salt thereof are excluded.

The present invention relates to: a bisoprolol-containing adhesive patch which comprises a supporting body and an adhesive layer that is formed on at least one surface of the supporting body and contains bisoprolol, and wherein the adhesive layer has a moisture content of 10,000 ppm or less; and a package of a bisoprolol-containing adhesive patch, which is obtained by sealing the bisoprolol-containing adhesive patch in a bag that has resistance to water vapor permeation. A bisoprolol-containing adhesive patch according to the present invention achieves excellent long-term stability of bisoprolol that is contained in the adhesive layer. In addition, a package of a bisoprolol-containing adhesive patch according to the present invention has excellent usability and portability.

An adhesive preparation containing bisoprolol includes a backing and a pressure-sensitive adhesive layer formed on one side of the backing. The pressure-sensitive adhesive layer contains a polymer prepared through copolymerization of monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer (component (A)), a polymer prepared through copolymerization of monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer (component (B)), and bisoprolol (component (C)).

Stable solid pharmaceutical composition containing amlodipine or pharmaceutical acceptable salts thereof and bisoprolol or pharmaceutical acceptable salts thereof as well as pharmaceutically accepted excipients, packaged in a damp- proof package and further comprising less than 0.5 % of the compound of the formula (3) based on the weight of the active ingredients.

The present invention relates to a bisoprolol-containing adhesive patch that is provided with: an adhesive patch body that comprises a support body and an adhesive layer that contains bisoprolol and that is formed on one surface of the support body; and a peeling liner that is temporarily attached to the adhesive surface of the adhesive layer of the adhesive patch body. The peel force between the adhesive layer and the peeling liner is equal to or less than 0.07 N/24 mm width. This bisoprolol-containing adhesive patch minimizes the adhesion thereof to the inner surface of a packaging material, can be extracted with extreme ease at the time of use, and has good peeling liner peelability at the time of use.

The invention discloses a solid preparation of a bisoprolol/hydrochlorothiazide medicine composition liposome and a preparation method thereof. Active components of bisoprolol fumarat, hydrochlorothiazide and specified compositions of hydrogenated granulesten, dilauroyl phosphatidylcholine, cholesterol and tween 60 are prepared into the liposome. Stability, dissolution rate and biological utilization rate of a medicine are greatly improved, functions are stable and durable, and curative effects are remarkable. The solid preparation of the bisoprolol/hydrochlorothiazide medicine composition liposome improves product quality and reduces toxic and side effects.