40results about How to "Suppress irritation" patented technology

An antimicrobial composition is provided in which the skin irritation of isothiazolone type compound is decreased and the injection operation properties thereof is improved by forming it as an uniform solution. The composition contains isothiazolone type compound and a compound which decreases the skin irritation of the former in a molar ratio of 1:0.1-50 and is dissolved in a solvent.

A contact lens distribution / storage method with which contact lenses can be reliably stored in a small space. To achieve this with a method for storing contact lenses for distribution using a contact lens package containing a packaging solution and the contact lens, a soft contact lens is used as the contact lens. A fluid volume of the packaging solution is 0.1 to 1.0 mL, and a buffering capability of the packaging solution is 3 mmol / L or greater measured in buffering capacity.

The present invention relates to isolated protein sequences that correspond to cell binding peptides, fragments, neo-structures and / or neo-epitopes of a normally occurring serum protein present in human tissue, wherein the peptide, fragment, neo-structure and / or neo-epitope has an immunoregulatory activity and is the result of either an enhanced proteolytic activity and / or conformational changes in a tissue, or a malignant tumour. In the present patent application, a common structure of several of these peptides, fragments, neo-structures and / or neo-epitopes, having immunoregulatory activity by binding to receptors on immune cells, has been identified. The present invention further also relates to monoclonal and / or polyclonal antibodies directed to a cell binding fragment of a normally occurring serum protein present in human tissue, as described above.

Provided is a fentanyl transdermal patch comprising an acrylic-rubber hybrid as a drug-adhesive layer. The fentanyl transdermal patch can maintain constant fentanyl skin permeability for three days by maintaining close contact with the skin such that desorption, release by moisture and sweat, and skin stimulation are all improved.

To provide skin external preparations characterized in that the initial permeation rate of oil-soluble drugs (e.g. retinol and tocopherol acetate) is controlled to achieve their sustained release to thereby reduce skin irritation and that they also possess a fresh feel while featuring high degrees of safety and stability. A skin external preparation which comprises a finely dispersed, oil-soluble drug containing wax composition, the composition containing a solid or semisolid wax, a nonionic surfactant, an aqueous dispersion medium, and an oil-soluble drug, the mass ratio of the nonionic surfactant to the wax being 1.0 or more, and the wax, with the oil-soluble drug contained therein, being finely dispersed in solid or semisolid form in the aqueous dispersion medium.

Topical formulations containing aqueous-soluble divalent strontium cation in a suitable topical formulation vehicle, and methods of using these formulations to inhibit skin irritation, are disclosed.

The present invention provides a medical adhesive and a medical adhesive tape or sheet superior in the fixing performance, particularly perspiration-resistant fixing, which shows low skin irritation and suitable adhesive strength. The present invention provides a medical adhesive containing a water-dispersed copolymer obtained by copolymerizing 100 parts by weight of a monomer mixture containing (meth)acrylic acid alkyl ester and 0.005-2 parts by weight of a silane monomer copolymerizable with the ester, and an organic liquid component compatible with the copolymer; a medical adhesive containing a water-dispersed copolymer obtained by copolymerizing a monomer mixture containing (meth)acrylic acid alkyl ester and a silane monomer copolymerizable with the ester, and an organic liquid component compatible with the copolymer, wherein the gel fraction after crosslinking of the copolymer is 40-80 wt %, and the weight average molecular weight of a sol component after crosslinking is not less than 300000; and a medical adhesive tape or sheet having the medical adhesive at least on one surface of a support.

The invention discloses a food therapy composition capable of preventing and treating diabetes and a making method thereof. The food therapy composition is prepared from the following raw materials by weight: 3 to 30 grams of pear peel, 3 to 30 grams of green tofu skin, 3 to 30 grams of chicken's gizzard-membrane, 0.05 to 0.1 gram of cinnamon, 1 to 2 grams of sharp-leaf galangal fruit, and 1 to 2grams of raspberry. The food which has good mouthfeel and is suitable for daily meals of diabetes is prepared by the 'medicinal and edible' material formula.

The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg / cm2 / hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg / cm2 / hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.

Disclosed is an ophthalmic composition which is characterized by containing (A) a vitamin A, (B) a polyoxyethylene polyoxypropylene glycol, and (C) an oil component that is selected from the group consisting of castor oil, soybean oil, sesame oil, peanut oil, olive oil, almond oil, wheat germ oil, corn oil, rapeseed oil, sunflower oil, purified lanolin and gel hydrocarbon.

The present invention relates to a percutaneous absorption preparation that is lower skin irritation and enables efficient transdermal administration of an anti-dementia drug. More specifically, the present invention relates to a percutaneous absorption preparation comprising an anti-dementia drug, a polymer compound having an amino group, a polyvalent carboxylate ester, a fatty acid alkyl ester, a styrenic polymer compound, and a tackifier resin.

Disclosed is a transdermal absorptive liquid preparation in which a medicament or a salt thereof is colloidally dispersed in propylene glycol or a propylene glycol-containing solvent, whose transdermal permeability of the medicament is excellent, problem of skin irritation is reduced. This transdermal absorptive liquid formulation has a mode of particle diameter at around 100 nm, and an average particle size of 50 to 500 nm. This transdermal absorptive liquid formulation makes marked improvement in the transdermal permeability by further containing an absorption promoter such as triethanolamine.

A process for treating psoriasis and similar skin disorders whereby two formulations are used. The first formulation in a cream, gel, lotion, foam or ointment base is used two or more times daily, and contains effective amounts of (but not limited to) methylcobalamin, niacinamide, select cetylated fatty esters, and antioxidants. This formulation is used to suppress immunoproliferative and inflammatory mediated activities that play significant roles in hyperproliferation and erythema. The second formulation, used selectively to reduce plaque thickening and to reduce irritation, contains effective amounts of (but not limited to) salicylic acid and select cetylated fatty esters in a cream, gel, lotion or ointment base, with pH optimized for exfoliation properties. The unique combination of salicylic acid (or other β- or α-hydroxy acid) and cetylated fatty esters provides keratolytic activity while suppressing irritation and inflammation. The invention for this novel two-step polytherapy, are disclosed including the mode of sequential administration.

The colored cigarette paper comprises a cigarette paper base material and a coloring material, and is characterized in that the coloring material is melanoidin generated by deep reaction of natural amino acid and reducing sugar; the cigarette paper base material comprises plant fiber and inorganic filler, and the cigarette paper further comprises a combustion improver. Compared with the prior art,the method has the characteristics that macromolecular substance melanin is generated after deep reaction of amino acid and reducing sugar, wherein the substance is dark brown in color and can be used for cigarette paper dyeing. Meanwhile, when the cigarette paper is burnt, pyridine, pyrazine and pyrrole substances generated by pyrolysis of the substances have the effects of inhibiting paper burning gas and irritation of the cigarette paper, and the pyrolysis substances also widely exist in cigarette smoke and have good smoke compatibility. The melanoidin is widely distributed in food, has the characteristics of safety and edibility, and avoids the potential safety hazard caused by the use of synthetic dyes.

The invention provides a spicy seasoning packet and a preparation method thereof, and relates to the field of seasoning. The spicy seasoning packet is prepared from the following raw materials: green Chinese onion, onion, garlic, star anise, cardamom, cassia bark, amomum tsao-ko, fennel, bighead atractylodes rhizome, clove, bay leaf, hot pepper, Chinese prickly ash, crushed peanut, hawthorn, sesame seed, thick broad-bean sauce and long pepper. The long pepper, the green Chinese onion and the onion can achieve the effects of removing fishy smell and peculiar smell. Star anise, cardamom, cinnamon, amomum tsao-ko, fennel, bighead atractylodes rhizome, clove, pepper and myrcia provide complex and rich spice fragrance for the whole seasoning bag, hawthorn can stop greasiness, thick broad-bean sauce is used for improving color and flavor, pepper and pepper provide spicy and spicy taste, hawthorn and chopped peanuts can inhibit irritation of pepper to the oral cavity, and it is guaranteed that the seasoning bag is spicy but not irritating.

The invention discloses anti-wrinkle eye gel and a preparation method thereof, and belongs to the technical field of cosmetics. The anti-wrinkle eye gel comprises 0.05%-0.3% of xanthan gum, 5.0%-8.0%of glycerol, 1.0%-2.0% of hexanediol, 2.0%-3.0% of pentanediol, 0.05%-0.2% of allantoin, 0.1%-0.5% of sodium hyaluronate, 0.5%-5.0% of acetyl hexapeptide-8, 2.0%-5.0% of hydrolyzed collagen, 0.5%-2.0%of Chinese herbal medicine extract, 0.5%-2.0% of panthenol, 2.0%-5.0% of vitamin C and the balance of deionized water. The preparation method comprises the steps: adding the component A and the deionized water into an emulsifying pot, stirring and homogenizing until the component A and the deionized water are completely dissolved, heating to 85-90 DEG C, keeping the temperature for 30 minutes, cooling to 50 DEG C, adding the component B into the same emulsifying pot, and stirring until the component B is completely dissolved; cooling to 45 DEG C, adding the dissolved component C, uniformly stirring, and continuously cooling; and when the temperature is reduced to 40 DEG C, sampling and performing central control to obtain a finished product. The obtained anti-wrinkle eye gel is mild in component, reasonable in matching, capable of effectively repairing wrinkles and preventing and delaying aging of eye skin, safe and free of irritation.

The invention relates to an externally applied medicine and in particular to compound sweet zinc cream used for treating eczema of an infant and a preparation method thereof. The compound sweet zinc cream provided by the invention mainly comprises dipotassium glycyrrhizinate, baicalin, zinc oxide, nicotinamide, menthol, vitamin E, glycerin three castor acid polyoxyethylene ester 35 and isopropyl myristate; the preparation method of the compound sweet zinc cream comprises the following steps: respectively taking glycerin three castor acid polyoxyethylene ester 35, isopropyl myristate, vitamin E and menthol to prepare solution A; taking zinc oxide and baicalin, adding a right amount of water at the temperature of 50-60 DEG C to prepare solution B, taking dipotassium glycyrrhizinate and nicotinamide to prepare solution C, adding solution B into solution C, stirring to be uniform, then adding mixed solution into the solution A, stirring for 20-30 minutes, so as to obtain semi-transparent orange emulsion, and split charging, so that the compound sweet zinc cream is obtained. Clinical curative effect observation shows that the effective rate of the compound sweet zinc cream prepared by adopting the preparation method provided by the invention for treating the eczema of the infant can reach up to 91%, and the compound sweet zinc cream can be directly applied to skins and hairs and is good in dispersibility, easy to clean and convenient to use.

The invention discloses a functional purslane composition. The functional purslane composition has the rapid allergy relief, restoration and protective screen functions and can effectively improve the condition of the surface of the skin. The functional purslane composition comprises a purslane extract, a high-molecular compound of the phospholipid structure, an amino-acid ester and a solvent capable of being applied to household chemicals. The active matter content of the purslane extract is 0.1%-30.0%. The content of the high-molecular compound of the phospholipid structure is 0.1%-30.0%. The content of glutamate is 0.1%-50.0%. The functional purslane composition can be widely applied to daily chemicals, especially skin care products.

The invention belongs to the technical field of health coffee preparation and particularly relates to health coffee with traditional Chinese medicinal ingredients and a preparation method thereof. Thehealth coffee is prepared from the following raw materials in parts by weight: 60-70 parts of licorice roots, 100-150 parts of ground coffee, 30-50 parts of honey, 160-220 parts of radix rehmanniae praeparata, 100-120 parts of angelica sinensis, 150-200 parts of haws and 50-100 parts of pericarpium citri reticulatae. The preparation method comprises the following steps: grinding the licorice roots, angelica sinensis, haws and pericarpium citri reticulatae into powder; slicing the radix rehmanniae praeparata, boiling the sliced radix rehmanniae praeparata with water, filtering out residues, and extracting medicinal liquid; adding coffee beans into the medicinal liquid, boiling the mixture to obtain coffee liquid rich in traditional Chinese medicines; and performing filtration, collecting medicinal liquid, performing concentration, air-drying, sterilization, package and storage. The health coffee has the refreshing and leisure characteristics of original coffee drinks, has functions oftreating and preventing diseases, has the effects of remarkably relieving fatigue, inhibiting the stimulation of coffee on nervous centralis, stomach and heart and blood vessels, improving myocardialanoxia, promoting intestinal and gastric digestion and reducing the situation of poor excretion and emotional instability, and has health protection and maintenance effects.

The invention relates to a ground negative-pressure oil extraction process and a device thereof. An oil extraction method comprises introducing a composition as follows into a stratum oil well and extracting oil by using a negative-pressure method; the composition is prepared from a main agent and a synergist, wherein the main agent is prepared from the following components in parts by weight: 15-25 parts of a betaine derivative, 3-7 parts of a glucoside derivative, 10-20 parts of alkane sulfonate, 5-10 parts of heterocyclic salt and 5-10 parts of naphthyl sulfonate; the synergist is preparedfrom at least two of the following components: 2-5 parts of guar gum, 3-5 parts of lignin and 2-5 parts of triethanolamine. Through the ground negative-pressure oil extraction process and the device thereof, the oil is extracted by adding the corresponding composition and the negative-pressure oil extraction process; the effect is obvious; through the interaction between the main agent and the synergist, the oil-water interfacial tension is greatly reduced, and the emulsifying capability is improved; the composition has high salt resistance and high resistance to high temperature, and is capable of resisting the special environment of a stratum and achieving a good oil extraction effect and high oil extraction mount during specific oil extraction.

The invention discloses a composition for enhancing immunity as well as a preparation method and application thereof, and belongs to the technical field of health care products and medicines. The composition for enhancing immunity comprises a component A and a component B, wherein the component A comprises the following substances in percentage by weight: 1-20% of basidiomycetes, 1-10% of euglena,1-20% of yeast beta-glucan, 1-10% of roxburgh rose, 1-10% of honeysuckle flowers and 1-5% of a broccoli seed extract; the component B comprises the following substances in percentage by weight: 10-80% of soybean peptide and 10-50% of collagen peptide; and the component A and the component B are placed into a stirrer to be mixed and stirred, carrying out discharging for later use, and performing mixing and canning to obtain a finished product. The composition can effectively enhance the immunity, and the components are mild and safe; and according to the preparation method of the composition,the activity of all the substances can be maintained, all the components are fully reacted, the overall efficacy and effect are synergistically improved, the irritation of the components is reduced, and the effects of mildness and no irritation are achieved.

The present invention relates to a percutaneous absorption preparation comprising an anti-dementia drug, which is lower skin irritation. More specifically, the present invention relates to a percutaneous absorption preparation comprising a drug-containing layer comprising an anti-dementia drug, a polymer compound having an amino group, a polyhydric alcohol fatty acid ester, a polyhydric alcohol, a polyvalent carboxylate ester, and a styrenic polymer compound, wherein the content of the anti-dementia drug is 0.5-20 mass % of the drug-containing layer.

The invention discloses a high-efficiency camphor mothproof tablet with a mildew-proof function, and particularly relates to the technical field of mothproof tablets, and the high-efficiency camphor mothproof tablet is prepared from the following raw materials in percentage by weight: 90-94% of camphor, 0.12-0.15% of sandalwood powder, 0.3-0.6% of potassium sorbate, 0.12-0.25% of glycerol, 0.15-0.55% of phenyl salicylate, 0.01-0.05% of N, N-dimethyl formamide, 0.01-0.05% of magnesium stearate and the balance of water. The cleaning agent is prepared from the following components in percentage by weight: 0.24 to 0.28 percent of nickel N, N-di-n-butyl dithiocarbamate, 0.24 to 0.28 percent of fatty alcohol-polyoxyethylene ether, 0.01 to 0.04 percent of sorbic acid, 0.43 to 0.56 percent of fructus kochiae powder, 0.18 to 0.2 percent of silicone oil, 0.25 to 0.45 percent of alkylolamide, 0.04 to 0.2 percent of allicin powder, 0.1 to 0.3 percent of sophocarpidine, 0.3 to 0.7 percent of cortex meliae powder, 0.02 to 0.04 percent of betel nut powder, 0.12 to 0.15 percent of radix stemonae and the balance of water. By adding the sandalwood powder, skin can be softened, the phenomenon of itching or inflammation of the skin can be improved, the stimulation effect of camphor on mucous membranes and the skin is inhibited, no mildew spot is generated, and the good mildew-proof effect of the camphor is reserved.

The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg / cm2 / hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg / cm2 / hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.