5 results about "Glycerite" patented technology

The application discloses brake fluid for One-Box brake-by-wire system and a preparation method thereof, the brake fluid comprises triethylene glycol monomethyl ether borate, glycerol acid ester, triethylene glycol monobutyl ether, tetraethylene glycol monomethyl ether, diethylene glycol, anti-rust agent, antioxidant and pH value regulator. The brake fluid can reduce the friction coefficient to <=0.14 under the SRV test condition, the friction coefficient is reduced by 10% compared with that of traditional brake fluid, the abnormal sound and wear problem caused by poor lubrication of the brake system is effectively solved, and the reliability and safety of the brake system of the new energy vehicle are remarkably improved; in addition, the brake fluid also has low temperature kinetic viscosity (-40 DEG C) <=1000mm 2 / s, the pH value is controlled to be 7.5-8.0, and excellent corrosion prevention performance of the product is ensured.

The invention provides low-viscosity modified natural ester insulating oil and a preparation method thereof, and relates to the technical field of insulating media. Glycerate in the natural ester is converted into short-chain fatty acid ester through transesterification of the natural ester and short-chain alcohol, and then the kinematic viscosity of the product at 40 DEG C is reduced to 8 mm / s or below. According to the prepared low-viscosity modified natural ester insulating oil, the kinematic viscosity is remarkably reduced while excellent biodegradability is reserved, and the bottlenecks of low heat dissipation efficiency, high circulating energy consumption and the like caused by high viscosity of traditional natural ester are effectively overcome; meanwhile, the product also has better low-temperature fluidity and good oxidation stability.

The present application relates to a sustained-release pharmaceutical composition of GLP-1 receptor agonist and a preparation method thereof. The composition comprises 0.05-0.5 wt% active ingredient, 45-85 wt% sustained-release agent, and 15-55 wt% viscosity reducer, or comprises 0.05-0.5 wt% active ingredient and 45-99.95 wt% thermal sensitive sustained-release agent. The active ingredient is GLP-1 receptor agonist, the sustained-release agent is polyorthoester, and the viscosity reducer is preferably glycerate compound. The present application also provides a pharmaceutical combination product comprising the sustained-release pharmaceutical composition, and application of the composition in treating metabolic related diseases. The sustained-release pharmaceutical composition has significantly improved pharmacokinetic characteristics, can realize long-acting administration, improve patient compliance, and shows excellent effects in improving blood glucose control, promoting weight loss, and improving blood lipid level.

Provided are a sustained-release pharmaceutical composition of a GLP-1 receptor agonist and a preparation method therefor. The composition contains 0.05 wt% to 0.5 wt% of an active ingredient, 45 wt% to 85 wt% of a sustained-release agent, and 15 wt% to 55 wt% of a viscosity-reducing agent, or contains 0.05 wt% to 0.5 wt% of an active ingredient, and 45 wt% to 99.95 wt% of a thermal sensitive sustained-release agent, wherein the active ingredient is a GLP-1 receptor agonist, the sustained-release agent is a polyorthoester, and the viscosity-reducing agent is preferably a glyceryl ester compound. Further provided are a drug-medical device combination product containing the sustained-release pharmaceutical composition, wherein the drug is the above-described sustained-release drug, and the medical device is a jet microneedle capable of injecting high-viscosity substances, and the use of the composition in the treatment of metabolism-related diseases. The sustained-release pharmaceutical composition has significantly improved pharmacokinetic characteristics, can realize long-acting administration, improves patient compliance, and exhibits good effects in improving blood glucose control, promoting weight loss, improving blood lipid levels, etc.

The present application relates to the technical fields of epoxy resin synthesis, and particularly relates to a vegetable oil-based epoxy resin material, a preparation method and application thereof; the present application takes glycerol and fatty acid obtained by hydrolysis and separation of vegetable oil as raw materials; the fatty acid is subjected to esterification reaction with a cycloalkene alkanol compound, and the obtained product is subjected to epoxidation reaction to obtain an epoxy cycloalkyl fatty acid ester first monomer; the glycerol is subjected to esterification reaction with a cycloalkene alkanol compound, and the obtained product is subjected to epoxidation reaction to obtain a tricycloepoxy cycloalkyl glycerol ester second monomer; the first monomer and the second monomer are uniformly mixed and solidified to obtain the vegetable oil-based epoxy resin material; the material has high strength, strong weather resistance, and can be used as an adhesive, a plasticizer, a toughening agent and the like, and has wide application advantages.