This invention discloses a method for synergistic
moisture-proof and
flavor-masking
coating of
traditional Chinese medicine granules, belonging to the field of
pharmaceutical formulation technology. The method includes: S1, obtaining
porous starch by
enzymatic hydrolysis,
ferric chloride complexation, and integrated twin-screw
extrusion-
enzymatic hydrolysis of
corn starch, followed by surface ammoniation modification with 3-aminopropyltriethoxysilane and then mixing and adsorbing with
traditional Chinese medicine granules to obtain granules covered with a sacrificial inner layer; S2, alternately
coating the granule surface with
sodium carboxymethyl cellulose and poly-L-
arginine through layer-by-layer self-
assembly to form a composite intermediate layer; S3, in-situ
coordination polymerization of
tannic acid and
ferric chloride on the granule surface to form a
polymer coating layer; S4, freezing the granules and then using a mixture of behenicol glyceryl ester and cocoa butter as the hot-melt coating material, followed by
fluidized bed hot-melt coating. This invention solves the problems of the prior art, such as the separation of
moisture-proof and
flavor-masking functions, easy escape of volatile oils, and insufficient coating density. The resulting granules have low
moisture absorption, high volatile
oil retention, long-lasting
flavor masking, and precise pH-responsive
drug release.