1826results about How to "Composition is stable" patented technology

Provided is a method of manufacturing a large-sized vanadium oxide thin film having a uniform surface, uniform film thickness and stable composition. According to the method, a vanadium-organometallic compound gas is injected into a chamber to form adsorption layer where molecules of the vanadium-organometallic compound are adsorbed on the surface of a substrate. After that, an oxygen precursor is injected into the chamber and thus allowed to accomplish surface-saturation reaction with the adsorbed materials to fabricate a vanadium oxide thin film.

Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a surfactant. The compositions induce a local-anesthetic effect when topically administered to intact skin thereby treating or preventing pain, for example, neuropathic pain.

Novel compositions containing imiquimod which are suitable for use in the treatment of skin disorders are disclosed. The compositions comprise micronized imiquimod and pharmaceutically acceptable excipients.

Disclosed is a polyol-in-silicone emulsion comprising: (a) a continuous silicone phase; (b) a discontinuous polyol phase; (c) a branched polyether-polydiorganosiloxane emulsifier; (d) an alkyl dimethicone copolymer emulsifier; and (e) a thickener for stabilizing the composition.

Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 9% or less or 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 25%, about 20%, about 15% or about 10% after six months of accelerated stability testing and the titer level of a viral contaminant present in the pancreatin is at least about 1000 times less than the titer level of the viral contaminant present in a preparation from which the pancreatin is obtained.

CO2 sequestering soil stabilization compositions are provided. The soil stabilization compositions of the invention include a CO2 sequestering component, e.g., a CO2 sequestering carbonate composition. Additional aspects of the invention include methods of making and using the CO2 sequestering soil stabilization composition. The invention also comprises the method of stabilizing soil and producing a soil stabilized structure utilizing such compositions.

Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.

The invention is an encapsulated active agent comprising an active agent encapsulated in a crystallizable or thermoplastic polymer wherein the particle size of the encapsulated active agent is 3,000 microns or less wherein the active agent is not significantly extractable from the particles under ambient conditions. In another embodiment the invention is a process for preparing an encapsulated agent which comprises a) contacting an active agent with a crystallizable or thermoplastic polymer wherein the polymer is molten and the active agent in not volatile under the contacting conditions; b) forming particles of about 3000 microns or less; and c) exposing the particles to conditions such that the portion of the particle at and near the surface undergoes rapid solidification. The encapsulated active agents of the invention do not require washing in order for them to be stable in curable compositions. These encapsulated active agents can be designed to release the active agent at a desired temperature. The encapsulated agents of the invention demonstrate excellent stability at ambient temperatures and exhibit relatively rapid reactivity upon release of the active agent. Furthermore, the presence of the encapsulating agent does not result in deterioration of adhesive or elastomer properties of a cured composition after preparation.

The present invention describes wet wipe impregnated with a lotion composition where the lotion includes a preservative system and soothing ingredients to mitigate stinging.

Disclosed are glyceride compositions, methods of making the glyceride compositions, and nutritional formulations containing the glyceride compositions. The glyceride compositions contain predominantly monoglycerides and diglycerides carrying one or more long chain polyunsaturated fatty acids. Also disclosed are methods of using the glyceride compositions and nutritional formulations.

Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.

This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals. The present invention further relates to methods using whole antibody crystals, antibody fragment crystals, or compositions or formulations comprising such crystals for biomedical applications, including biological delivery to humans and animals. More particularly, whole antibody crystals or antibody fragment crystals, or crystal compositions or formulations thereof, are used as a carrier-free delivery system which can slowly release active whole antibodies or fragments thereof, to a subject, where and when they are needed.

Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a surfactant. The compositions induce a local-anesthetic effect when topically administered to intact skin thereby treating or preventing pain, for example, neuropathic pain.

A novel cement slurry composed of cement and water that can be used in cement stabilization applications. The cement slurry compound itself is chemically treated, by means of a cellulosic or other thixotropic thickening agent(s) to create a thixotropic system wherein the wetted cement remains in suspension and does not settle out prior to use even without further mixing. A chemical retarder / stabilizer is also used to prevent the slurry from prematurely setting during shipping. A novel apparatus and method for mixing the novel cement slurry is disclosed to insure the exact proportioning of all ingredients and the proper wetting of the cement.

A manufacturing method and structure for better phase change memory characteristics by improving the interface and the hole-filling properties. The present invention can reduce the power consumption needed to operate and is easy to fabricate.

The invention provides compositions containing one or more sterol compounds and one or more fatty acid compounds. The invention also provides methods for reducing CVD risk factors such as LDL cholesterol levels.

The invention relates to the technical field of clinical medicines, and particularly relates to a cell preservation solution and a preparation method and applications thereof. The cell preservation solution comprises albumin, glucose, vitamin C and basic preservation liquid, wherein the basic preservation liquid is a mixture of compound electrolyte injection and compound amino acid injection. The cell preservation solution disclosed by the invention achieves a good maintaining effect on the viability and morphology of more than two kinds of seed cells, and can preserve the seed cells for a long time, and maintain the biological characteristics of the seed cells, thereby significantly improving the therapeutic effect of the seed cells.

This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals.

A chrome-free composition of an acidic suspension of manganese compounds and manganese ions are applied to an organic polymer surface to etch the surface. The etched surface is then plated with metal.

An improved cleaning composition loaded on a cleaning wipe having improved biocidal release from the cleaning wipe. The improved cleaning composition includes a cationic biocide and a biocide release agent.

This invention provides for compositions, which can be crosslinked by radiation to give elastomeric coatings, which comprises: (a) high-molecular weight siloxanes with multiple (meth)acrylate functional groups; and (b) reinforcing fillers selected from the group consisting of silicone resins and silicone dioxide fillers, wherein the siloxanes (a) have the general structure: [R3SiO1 / 2]a[(Z)nG-Ym-R2SiO1 / 2]a'[R2SiO2 / 2]b[(Z)nG-Ym-RSiO2 / 2]b'[RSiO3 / 2]c[SiO4 / 2]d.

The present invention relates to antibodies with decreased deamidation profiles, and methods for producing antibodies with decreased deamidation profiles.

Moisture-curing binder comprisinga) a silane-modified polyurethane andb) a silane-modified acrylate polymer,with the binder being able to cure in the presence of moisture.

The present invention relates to a topical cosmetic composition that has improved non-oily feel comprising: (a) a hybrid silicone composite powder having a spherical shape with particle diameter ranging from 2 to 10 μm, of which each particle has a composite structures consisting of two interpenetrating polymer networks of polydimethylsiloxane (PMS) and polymethylsilsesquioxane (PMSQ). These two interpenetrating polymer networks are joined together by physical entanglements instead of chemical bonds; (b) a volatile cosmetic fluid; (c) a silicone fluid with viscosity ranging from 2 to 350 cSt; (d) an oil base consisting of an oil, wax, oil gelling agent or the mixture thereof; (e) a surface active agent; (f) a cosmetic pigment; and (g) an optional aqueous gel containing glycerin, glycols and an aqueous thickening agent. The cosmetic composition provides an improved skin sensory feel and a superior matte finish, and is useful for skin treatment, makeup and personal hygiene products.

The invention relates to a method for preparing nano iron phosphate, belonging to the technical field of the preparation of lithium ion battery cathode materials. The method is characterized by comprising the following steps: inputting an alkaline aqueous solution and a mixed solution formed by one of phosphoric acid or a soluble phosphate solution, one of a water-soluble ferrous salt solution and an oxidant or a ferric salt solution and a water-soluble dispersing agent into a rotating packed bed layer by a metering pump at a certain feeding speed; regulating the rotating speed of the rotating packed bed and controlling the pH value of the reaction system by an alkaline solution; discharging nano iron phosphate particles generated by reaction crystallization from a discharge hole of the rotating packed bed along with the mixed solution; and filtering, washing and drying the nano iron phosphate particles to obtain nano iron phosphate (FePO4.2H2O) powder. The method is simple and has easy operation and high efficiency, and the prepared iron phosphate reaches the nano grade, has uniform particle size and narrow distribution range and is suitable for industrialized production. The nano iron phosphate is a good precursor material for preparing lithium iron phosphate which is used as a cathode material of high-power type lithium ion batteries.

The invention discloses a PVC wood-plastic low foaming granule material and a preparation method thereof, and belongs to the technical field of wood-plastic materials. The PVC wood-plastic low foaming granule material comprises the following substances in portion by weight: 20 to 60 portions of wood powder or / and bamboo powder, 100 portions of polyvinyl chloride, 2 to 12 portions of composite stabilizing agent, 5 to 60 portions of CaCO3, 0.6 to 6 portions of foaming agent, 2 to 16 portions of assistant foaming agent, 1 to 10 portions of processing assistant, 0.6 to 6 portions of lubricating agent, 0.6 to 4 portions of coupling agent, and 0.1 to 0.8 portion of paint. The method for preparing the PVC wood-plastic low foaming granule material comprises the following steps: mixing and heating the substances; plasticizing the substances; extruding the substances into columnar granules; and separating and packing the granules as a product. The PVC wood-plastic low foaming granule material has relatively stable components and lighter texture, and is convenient to transport, store and process. The preparation method is simple and practical, saves energy, and saves investment; and the quality of the product is stable.

The invention discloses a heavy metal stabilizing agent and a method for treating heavy metal contaminated soil by using the heavy metal stabilizing agent. The heavy metal stabilizing agent is prepared from the following raw materials in percentage by weight: 40 to 50 percent of phosphate, 20 to 25 percent of bentonite, 25 to 30 percent of fluor apatite and 4 to 6 percent of sodium chloride / potassium chloride. When the heavy metal stabilizing agent is used for treating the contaminated soil, the heavy metal stabilizing agent and water are mixed together to form a suspension, then the suspension is added into the heavy metal contaminated soil, and the suspension and the heavy metal contaminated soil are fully mixed. The heavy metal stabilizing agent has high stability for treating soil, and the technical problem that the conventional curing agent and curing method cause reverse dissolution easily is solved.

The present invention provides novel formulations which mitigate agitation-induced aggregation of immunogenic compositions particularly those having polysaccharide-protein conjugates. Specifically, the novel formulations comprise a poloxamer within a molecular weight range of 1100 to 17,400 which provides significant advantages over previously used surfactants including polysorbate 80. In one embodiment, the present invention provides a multivalent immunogenic composition having 15 distinct polysaccharide-protein conjugates and a poloxamer. Each conjugate consists of a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F or 33F) conjugated to a carrier protein, preferably CRM197.