The invention discloses high-pressure self-packing leather cup rubber for a packer. The high-pressure self-packing leather cup rubber is prepared from the following raw materials in parts by weight: 30-40 parts of nitrile rubber, 20-30 parts of isoprene rubber, 20-40 parts of ethylene propylene terpolymer 5962 (LANXESS Deutschland), 10-15 parts of fluorosilicone rubber, 3-5 parts of natural rubber, 30-40 parts of high abrasion furnace black N330, 10-15 parts of modified white carbon black, 3-4 parts of antimony trioxide, 8-10 parts of modified wood ash, 4-6 parts of attapulgite, 4-6 parts of meerschaum, 9-11 parts of modified iron tailing slag powder, 0.5-1 part of stearic acid, 0.5-1 part of isocyanate, 0.2-0.4 part of accelerant DM, 0.3-0.6 part of accelerant BZ, 1-2 parts of calcium stearate, 2-4 parts of zinc oxide, 0.2-0.4 part of ferrocene, 1-2 parts of polyethylene wax, 1-2 parts of antioxidant DSTP, 1-2 parts of anti-aging agent, 2-3 parts of coupling agent DL-151 and 16-18 parts of epoxy linseed oil. The rubber disclosed by the invention has excellent ozone resistance, excellent low temperature resistance and heat resistance and is large in operating temperature range and environment-friendly in process, so that the rubber can be used for preparing various packing materials.