363 results about "Industrial scale" patented technology

Methods for preparing high entropy carbides (HECs), and powders thereof, are provided. One method includes spray-drying a base carbide feedstock and consolidating. Another method includes cold crucible induction of a base carbide feedstock. The HECs produced are of a quality suitable for use in industry. The methods are scalable in size, and suitable for use on an industrial scale. Also included are HEC feedstocks produced by the methods, and articles, such as coatings, produced from the HECs.

The invention relates to the technical field of coatings, discloses a high-solid epoxy seal primer suitable for a wet base surface and a preparation method of the high-solid epoxy seal primer, and aims to overcome the defect of poor application performance of the wet base surface in the prior art. A water-responsive curing system, dynamic interface modification components and a synergistic mechanism of precise cross-linking regulation are constructed, a special curing agent with anti-protonation characteristics is adopted and matched with a modified molecular sieve to adsorb water on a basal plane so as to weaken water interference, interface bonding is enhanced through a coupling agent containing dynamic covalent bonds and a composite filler, and the water-based composite material is prepared. The rheology regulation and control auxiliary agent is supplemented to optimize the construction performance, the environment-friendly component is fused to give consideration to the characteristic of low volatility, efficient curing of a high-water-content base plane is achieved, the interface stability and long-acting protection capacity of a coating and a base material are improved, the coating is suitable for industrial large-scale production, and the coating requirement in a humid environment is met.

This application provides a method for preparing compound I-b or a pharmaceutically acceptable salt thereof, wherein (S)-N-methylamino-1-(2-thiophene)-1-propanol reacts with 4-fluorobenzo[1,3]dioxolane in a system containing sodium hydride and potassium benzoate to obtain compound I-b. This method has short steps, mild reaction conditions, and is simple to operate, making it suitable for industrial scale-up; moreover, the obtained product has high purity and low isomer content.

The invention discloses a multi-stage fermentation method for improving thallus activity and stability, and particularly relates to the technical field of microbial fermentation. Dynamically dividing a fermentation period into a plurality of metabolic staging sections based on the multi-source physiological characteristic parameter set; constructing a multi-stage environment regulation and control model, taking the optimal control parameter vector of each stage as a control target, combining a real-time feedback signal set, and carrying out environment factor regulation through a model prediction control algorithm; calculating a thallus activity improvement rate and a fermentation stress anomaly index in real time, performing cross-batch correction on the multi-stage environment regulation and control model after fermentation is finished, and outputting an optimized parameter template for next fermentation calling; the dynamic self-adaptive control of the fermentation system can be realized, the thallus metabolism efficiency, the process stability and the fermentation repeatability are improved, and the method is suitable for industrial large-scale microbial fermentation production scenes.

The present invention relates to reactors and reactor components which have good resistance to NH3 and N2 and possibly to H2O at high temperatures and moderate pressures and thus can be used in industrial-scale reactions for the catalytic decomposition of NH3 into N2 and H2.

The present application relates to the technical field of solid-state lithium battery, and particularly relates to a sulfide solid electrolyte stable to lithium metal, a preparation method and application thereof. The sulfide solid electrolyte comprises a core of sulfide solid electrolyte particles and a surface coating material coating the core; the sulfide solid electrolyte particles adopt a sulfide solid electrolyte material stable to lithium metal, and the surface coating material adopts a two-dimensional sheet material capable of reacting with lithium metal in situ to generate a high ionic conductive interface layer. The sulfide solid electrolyte provided by the present application can generate a high ionic conductive interface layer promoting uniform deposition of Li metal in situ during the cycle process of the solid-state lithium battery assembled by the sulfide solid electrolyte, effectively inhibits lithium dendrites during the cycle process of the sulfide-based solid-state lithium battery, and improves the cycle life of the solid-state lithium battery. The material preparation process is simple and easy to operate, the coating material improves the air stability of the modified sulfide electrolyte, and is suitable for industrial scale-up operation.

The invention discloses a preparation method of a copper alloy crystallizer, and belongs to the technical field of copper alloy forming machining. According to the method, a copper alloy raw material serves as a basis, a cast ingot is prepared through burdening and vacuum melting casting in sequence, hot forging reaming operation is conducted on the cast ingot to form an alloy pipe blank, then the alloy pipe blank is machined into an intermediate pipe fitting through a spinning procedure, finally, aging treatment and subzero treatment are conducted on the intermediate pipe fitting in a combined mode, and the copper alloy crystallizer is finally prepared. According to the preparation method, the uniformity of alloy components is guaranteed through vacuum melting, precise plastic processing of the crystallizer is achieved by means of hot forging reaming and spinning forming, the alloy structure performance is optimized in cooperation with aging-cryogenic composite heat treatment, and the prepared crystallizer has excellent mechanical performance and service stability and is suitable for industrial large-scale production.

The present invention relates to the field of organic chemical synthesis, and specifically relates to a 6-bromonicotine synthesis method. The 6-bromonicotine synthesis method uses 6-hydroxymyosmine (CAS: 70969-38-9) as a starting material, which sequentially undergoes a reduction reaction, an amine methylation reaction and a bromination reaction, to finally obtain the target product 6-bromonicotine. The product purity of the 6-bromonicotine obtained by means of the synthetic route can reach 99.0% or more. The present synthesis method has a simple process and a high yield, and is suitable for industrial scale-up production.

The invention discloses a fuzzy intelligent control method and device for a pichia pastoris fermentation process. The fuzzy intelligent control method comprises the following steps: (1) integrating an online sensor in a bioreactor and monitoring state parameters of fermentation liquor in real time; (2) inputting the monitored parameters into a central control system, and processing the parameters through a fuzzy intelligent control algorithm; and (3) according to an output instruction of the fuzzy intelligent control algorithm, cooperatively regulating and controlling fermentation operation parameters in real time. According to the method disclosed by the invention, a fuzzy intelligent control algorithm is developed by monitoring dissolved oxygen, relative concentration of dissolved carbon dioxide, methanol concentration and pH in fermentation liquor in the fermentation process in real time, so that the fermentation process is accurately regulated and controlled by multi-parameter coordination, and the method is applied to process regulation and control of pichia pastoris fermentation expression recombinant protein. The expression quantity and the production efficiency of the recombinant albumin can be remarkably improved, the production period is shortened, and the method is suitable for industrial large-scale production.

The application belongs to the field of organic synthesis, and particularly relates to a cyclic anhydride compound and a preparation method and application thereof. The cyclic anhydride compound has a structure shown in formula (1'). The preparation method of the cyclic anhydride compound provided by the application is started from a polyhydroxy aromatic compound, and the cyclic anhydride compound can be constructed through three steps of Michael addition, cyano hydrolysis and intramolecular condensation, without complex protection group operation, and the reaction temperature is below 70 DEG C, high temperature and high pressure are avoided, and the method is suitable for industrial scale production, and the yield of the target product is stable at 60% to 80%. In addition, when the cyclic anhydride compound is used as a curing agent of an epoxy resin composition, the epoxy resin composition can have high high-temperature-resistant bonding strength and high Tg, and can meet the demand of the bottom filling adhesive in the field of semiconductor packaging. Formula (1')

The present invention relates to a method for separating and enriching a chlorine-37 isotope using a laser photochemical reaction and, specifically, to a method for separating and enriching a high-purity chlorine-37 isotope, which is essential for a next-generation molten chloride fast reactor (MCFR) and the like, by selectively photolyzing specific isotopic molecules of iodine monochloride (ICl) using a high-power fiber laser or a solid-state Raman laser and reacting same with a radical scavenger to effectively terminate a chain reaction. Accordingly, by employing, as a light source, a single-frequency fiber laser or a solid-state Raman laser that has higher power efficiency and easier maintenance than conventional dye lasers and is capable of achieving high power of several kW or more through modular expansion, mass production on an industrial scale can be realized and the economic feasibility of the process can be significantly secured.

The present invention relates to a process for enzymatic depolymerization of polyethylene terephthalate (PET), in particular contained in a plastic material. The process according to the invention can in particular be implemented on an industrial or semi-industrial scale.

The invention discloses and requests to protect a preparation method of high-purity norbornene alkyl silyl ether. Specifically, the invention discloses and requests to protect an industrial-scale preparation method of high-purity norbornene methyl silyl ether. The high purity monomers prepared according to the methods of the present invention can be used in a variety of applications, including but not limited to the preparation of high quality, high purity polynorbornene that can be used in a variety of electronics and other various applications.

The application provides a high-drug-loading porous breviscapine crystal and a preparation method thereof. The crystal is prepared by a solvent diffusion method, does not contain auxiliary materials, and has high drug purity. The crystal is a highly porous, spherical, round, particle-size-controllable, large-particle-size crystal particle, and is easy to implement in an industrial scale. The process is green, and the crystal is crystallized in an aqueous solution. The solvents used can be recycled and reused. The porous breviscapine crystal prepared by the application has rapid in-vitro dissolution, improved flowability and compressibility, and is beneficial to further preparation molding.

This invention discloses a method for preparing alkyl gallate without a dehydrating agent, belonging to the field of chemical reaction auxiliary technology. By optimizing the raw material ratio of the reaction system, precisely controlling the reaction environment parameters and the condensate separation rate, this invention utilizes the azeotropic properties of alcohol and water to achieve efficient separation of the water generated in the reaction. It can promote the forward esterification reaction without adding any dehydrating agent, achieving the same or even better water separation and reaction promotion effects without the need for a dehydrating agent. This invention eliminates the need for a dehydrating agent, and the synthesized methyl gallate, ethyl gallate, propyl gallate, octyl gallate, and lauryl gallate can reach a maximum content of 99.2%, with a stable product yield of 50-57g. This effectively reduces production costs, avoids the pollution problems caused by dehydrating agents, simplifies the production process, and possesses both green environmental protection and promising prospects for industrial-scale application.

Provided is a method for producing a catalyst that makes it easier to produce a supported metal catalyst for ammonia synthesis, which has limitations in production methods or production facilities, particularly, has large limitations in industrial-scale production, and that can produce the catalyst with high activity. This method for producing a catalyst for ammonia synthesis is characterized by comprising a first step for preparing 12CaO. 7Al2O3 having a specific surface area of 5 m2 / g or more, a second step for supporting a ruthenium compound on the 12CaO. 7Al2O3, and a third step for reducing the ruthenium compound-supported 12CaO. 7Al2O3 obtained in the second step. The reduction treatment is performed until the average particle diameter of the ruthenium after the reduction treatment is increased by at least 15% relative to the average particle diameter of the ruthenium before the reduction treatment.

The utility model relates to an automatic liquid batching device system, which comprises a stirring device, a pneumatic tank bottom valve is arranged at a discharge port at the bottom of the stirring device, and the pneumatic tank bottom valve is connected with a pressure container through a primary pneumatic ball valve; the top of the pressure container is independently connected with a pressure reducing valve and a pressure transmitter respectively, a metering device is arranged at the bottom of the pressure container, and a discharge port at the bottom of the pressure container is connected with the mixer through a secondary pneumatic ball valve; the automatic liquid batching device system further comprises a control system, and the control system is used for controlling opening and closing of the pneumatic tank bottom valve, the first-stage pneumatic ball valve and the second-stage pneumatic ball valve. According to the automatic liquid batching device system, automatic weighing and batching of liquid materials are achieved, the accuracy and efficiency are high, and the automatic liquid batching device system is suitable for industrial large-scale production.

The present invention provides a process route for producing auristatin derivative intermediates, which effectively avoids the use of norephedrine in the synthesis route compared to the prior art. Furthermore, the process route for auristatin derivative intermediates according to the present invention allows for the production of the target product in a single step, effectively avoids the generation of reaction intermediates, has a simple purification method, and produces a high yield and purity of the final product, making it suitable for industrial-scale scaling up.

The invention discloses an emulsifier reaction wastewater and waste oil recycling device, and aims to solve the technical problems of current emulsifier reaction wastewater and waste oil recycling equipment in the aspects of separation effect, automation degree, operation stability, maintenance cost and the like. A gravity sensing ring matched with the inner diameter of the recycling barrel in size is slidably mounted on the inner wall of the recycling barrel, and the gravity sensing ring is used for detecting the gravity of the waste; a one-way stroke transmission mechanism is mounted at the mounting end of the gravity sensing ring and is used for driving a waste discharge mechanism to operate; and a waste discharge mechanism is mounted at the mounting end of the one-way stroke transmission mechanism. Integrated operation of automatic solid, oil and water separation, automatic solid waste discharge triggered by gravity and respective resource recovery is achieved in the whole process, manual intervention is not needed, the separation efficiency is high, recovery is thorough, and the device is suitable for industrial large-scale wastewater and waste oil treatment scenes.

A gallium or indium doped S-1 molecular sieve encapsulated metal catalyst, its preparation method and application, especially in the application of low carbon alkane dehydrogenation. First, a gallium or indium doped S-1 molecular sieve slurry is prepared by a hydrothermal method, then the above catalyst is prepared through the steps of drying, impregnation, drying, dry gel crystallization reaction, calcination under nitrogen atmosphere, oxidation calcination under air atmosphere, and hydrogen atmosphere reduction. As a specific embodiment of catalyst performance evaluation, the above catalyst is evaluated for its performance in low carbon alkane dehydrogenation by taking propane dehydrogenation reaction as a model reaction. In the reaction process, no hydrogen is added, and a high propane conversion rate and propylene selectivity can be obtained, and the catalyst has good stability and good industrial application prospect. The preparation method is simple, and the dry gel material is crystallized, dried, formed, calcined and reduced to obtain the catalyst. In the preparation process, there is no water washing, filtration and other steps, which reduces the discharge of a large amount of wastewater containing metal and template, and is beneficial to industrial scale production.

The invention belongs to the field of organic synthesis, and particularly relates to a cyclic anhydride compound as well as a preparation method and application thereof. The cyclic anhydride compound has a structure as shown in formula (1). According to the preparation method of the cyclic anhydride compound, provided by the invention, the cyclic anhydride compound can be constructed by three-step reaction of Michael addition, cyano hydrolysis and intramolecular condensation on the basis of a polyhydroxy aromatic compound, complicated protecting group operation is not needed, the reaction is carried out at the temperature of 70 DEG C or below, high temperature and high pressure are avoided, and the preparation method is suitable for industrial large-scale production; and meanwhile, the yield of the target product is stabilized at 60-80%. Besides, when the cyclic anhydride compound is used as a curing agent of the epoxy resin composition, the epoxy resin composition has high high-temperature-resistant bonding strength and high Tg, and the requirements of the underfill in the field of semiconductor packaging can be met. Formula (1)

The application discloses a solvent separation and recovery process of a vinyl lubricating oil base oil, and comprises the following steps: step S1, obtaining organic solvent vapor and crude oil by removing the reaction liquid from a dissolving unit; step S2, obtaining refined solvent by refining the organic solvent vapor in a solvent rectification unit; step S3, obtaining tail gas condensate and tail gas non-condensable gas by condensing tail gas containing solvent vapor in a tail gas condensation recovery unit; and step S4, passing the tail gas non-condensable gas through a tail gas adsorption unit. The application mainly solves the problems of poor separation effect of reaction products, low product quality and inability to reach an industrial scale in the prior art.

The invention discloses a nano-fiber hybrid membrane with an arbor structure and a single-step batch preparation method and equipment of the nano-fiber hybrid membrane. The nano-fiber hybrid membrane with the Jornus structure is formed by uniformly mixing various nano-fibers with different Jornus structures, and based on the combination of a spinning solution insulation storage device and a needle head, an insulation container and a plurality of sets of metal capillary tube arrays penetrating through the insulation container are used as micro-fluid control transportation units for mixing the nano-fibers with the Jornus structure respectively; different parallel fluid combinations can be guided out from the bottom of an insulating container at the same time, multiple strands of different fluids are synchronously guided into a high-voltage electrostatic field, outlets of a series of parallel combination structures serve as macroscopic templates, and the Arnus structure nanofiber hybrid films are directly prepared in batches in a single step under the high-voltage electrostatic field and can be highly and uniformly mixed. The preparation method can solve the problems that the complete-structure nano-fiber hybrid membrane with the Arnus structure is difficult to prepare, and industrial scale is difficult to realize.

The invention belongs to the technical field of cosmetics, and particularly relates to a soothing and repairing composition and application thereof. The soothing and repairing composition provided by the invention is prepared from the stephania tetrandra extract, the phoenix dactylifera fruit extract, the flower extract and the mirabilis jalapa extract through specific compatibility, and all the components generate a synergistic effect, so that the transdermal absorption of active ingredients can be remarkably enhanced; experimental data show that the composition can effectively improve the hyaluronidase inhibition rate and the TNF-alpha inhibition rate, and has excellent soothing and repairing effects; the preparation method of the composition is simple and convenient to operate and easy to realize industrial large-scale production, and has a good industrial application prospect; when the composition is applied to the essence, the TEWL value improvement rate and the a * value improvement rate of the essence can be remarkably improved, and the soothing and repairing effects are obvious; and human body patch test results of the essence show that the essence is mild and non-irritating, so that the composition disclosed by the invention has wide market application value in skin care products.

The application discloses a kind of vinylidene acenaphthene double asymmetric alpha-diimine chemical intermediates and catalyst prepared from it, intermediate and the preparation method and application of catalyst. 2,4,6-tri-tert-butyl aniline is used as raw material, in the presence of catalyst, under the condition of 120 DEG C, the vinylidene acenaphthene double asymmetric alpha-diimine chemical intermediate with structure as shown in formula (I) is obtained.Compared with prior art, the application uses commercially available, low-cost and storage condition loose 2,4,6-tri-tert-butyl aniline instead of high-cost, storage harsh 2,4-di-tert-butyl aniline as reaction raw material, which effectively reduces the raw material procurement threshold and comprehensive production cost, and simplifies the storage condition.The raw material of the method is easy to obtain, low in cost, easy to operate, high in yield, and suitable for industrial scale-up production.

The invention relates to a process for treating permanent magnet blocks comprising at least a permanent magnet unit covered by a coating material and bonding products that glue magnetic units together to form a block, comprising the steps of applying a thermal treatment to the permanent magnet block to eliminate magnetism and remove organic components and reducing the demagnetized permanent magnet units to a micronized powder. The process is intended to be applied at industrial scale, for example to recycle magnets from wind farms.

The application discloses a kind of tunnel pavement with flame-retardant asphalt and preparation method thereof.Flame-retardant asphalt is based on matrix asphalt, carbon nanotube, fly ash and lignin are added as flame-retardant component.The best flame-retardant proportion of flame-retardant asphalt can be further obtained by central composite design model and comprehensive evaluation method.The preparation method includes matrix asphalt heating, flame-retardant component preheating, matrix asphalt and flame-retardant component step-by-step mixing, high-speed shearing and degassing processes, which can adapt to indoor test preparation process and industrial scale preparation process, with good adaptability and practicality.The application introduces carbon nanotube, fly ash and lignin to form a composite flame-retardant system, and the three components synergistically build a stable multi-scale flame-retardant structure, which significantly improves the flame-retardant performance of asphalt material, while considering environmental protection, economy and engineering adaptability, with significant engineering application value and promotion prospect.

The invention relates to a preparation method and application of a bimetallic catalyst resistant to CO poisoning. The catalyst comprises the following components in percentage by weight: 0.5% of Pt, 0.5% of Ru and 99% of TiO2. The bimetallic PtRu / TiO2 catalyst resistant to CO poisoning is developed by using an isovolumetric-co-impregnation method through a lattice matching induced epitaxial growth strategy, the electronic structure of the catalyst can be adjusted, the CO poisoning resistance of the catalyst can be effectively enhanced, and the bimetallic PtRu / TiO2 catalyst still shows excellent nitrobenzene hydrogenation performance under the conditions that the temperature is 35 DEG C and the CO content is 5000 ppm. The catalyst has the advantages of simple and easy synthesis process, mild preparation conditions, easy industrial amplification production, and wide application prospects.

The present invention relates to a biocatalytic synthesis of esters that can also be implemented on an industrial scale. In particular, the invention relates to a process for the production of esters, via a hemiacetal intermediate, consisting of the following steps: – a step of bringing into contact, in a reaction medium, • a mixture of a C1– Cn alcohol and a C1– Cn aldehyde with an enzymatic catalytic system comprising an oxidized cofactor selected from NAD(P)+ and NAD+ and a polypeptide of the oxidoreductase group having preferential dehydrogenase activity toward the formed hemiacetal and the starting aldehyde, or alternatively • a C1– Cn alcohol with an enzymatic catalytic system comprising an oxidized cofactor selected from NAD(P)+ and NAD+ and a polypeptide of the oxidoreductase group having preferential dehydrogenase activity toward the formed hemiacetal, the starting alcohol, and the formed aldehyde, or alternatively • a C1– Cn aldehyde with an enzymatic catalytic system comprising a reduced cofactor selected from NAD(P)H or NADH and a polypeptide of the oxidoreductase group having preferential dehydrogenase activity toward the starting aldehyde and the formed hemiacetal, where n may be any number, and – a step of isolating the corresponding ester.