601 results about "Industrial scale" patented technology

Methods for preparing high entropy carbides (HECs), and powders thereof, are provided. One method includes spray-drying a base carbide feedstock and consolidating. Another method includes cold crucible induction of a base carbide feedstock. The HECs produced are of a quality suitable for use in industry. The methods are scalable in size, and suitable for use on an industrial scale. Also included are HEC feedstocks produced by the methods, and articles, such as coatings, produced from the HECs.

The invention discloses a method for preparing an iron-nickel-molybdenum-based electrocatalyst through combination of electrodeposition and rapid Joule heat and application of the method. The method comprises the steps that S1, a porous nickel substrate is pretreated, and the pretreated porous nickel substrate is obtained; s2, obtaining a nickel salt solution, a molybdenum salt solution and a ferric salt solution; s3, obtaining a mixed solution; s4, putting the mixed solution serving as electrolyte into a dual-electrode electrolytic tank, carrying out electro-deposition treatment by taking the pretreated porous nickel substrate as a cathode and an inert electrode as an anode, and washing and drying to obtain a Fe-Ni-Mo-LDH precursor; and S5, carrying out Joule thermal pyrolysis treatment on the Fe-Ni-Mo-LDH precursor, so as to obtain the iron-nickel-molybdenum based electrocatalyst. The preparation method can effectively regulate and control the size structure of the catalyst, and is suitable for preparing iron-nickel-molybdenum-based electrocatalysts with different substrates and different sizes; and the electrocatalyst has the advantages of uniform and stable nanostructure and high loading capacity. Meanwhile, the preparation method is short in reaction time, high in heating efficiency, high in repeatability and suitable for industrial large-scale production.

The invention discloses a system and a method for predicting reaction conditions of a menthane carboxamide cooling agent, and aims to optimize the reaction conditions, improve the experiment efficiency, reduce the production cost and ensure the stable product quality through an intelligent method. According to the system, the design experiment DoE and the response surface method RSM technology are combined, the relation between reaction conditions and products is systematically analyzed, multi-scale modeling is utilized, a molecular reaction mechanism and a macroscopic reactor model are combined, seamless connection from a laboratory to an industrial scale is achieved, and challenges in the amplification process are solved. By means of real-time data monitoring and feedback adjustment, the system can dynamically optimize the reaction process, controllability and stability of the production process are improved, the scientificity and intelligent level of reaction optimization are improved, and an efficient, controllable and environment-friendly solution is provided for large-scale production of the menthane carboxamide cooling agent.

The invention relates to the technical field of coatings, discloses a high-solid epoxy seal primer suitable for a wet base surface and a preparation method of the high-solid epoxy seal primer, and aims to overcome the defect of poor application performance of the wet base surface in the prior art. A water-responsive curing system, dynamic interface modification components and a synergistic mechanism of precise cross-linking regulation are constructed, a special curing agent with anti-protonation characteristics is adopted and matched with a modified molecular sieve to adsorb water on a basal plane so as to weaken water interference, interface bonding is enhanced through a coupling agent containing dynamic covalent bonds and a composite filler, and the water-based composite material is prepared. The rheology regulation and control auxiliary agent is supplemented to optimize the construction performance, the environment-friendly component is fused to give consideration to the characteristic of low volatility, efficient curing of a high-water-content base plane is achieved, the interface stability and long-acting protection capacity of a coating and a base material are improved, the coating is suitable for industrial large-scale production, and the coating requirement in a humid environment is met.

The invention discloses a preparation method of biomass fiber aerogel for micro-plastic adsorption, and belongs to the field of micro-plastic adsorption. The preparation method comprises the following steps: (1) preparing a covalent cross-linking mixture by taking biomass nanofibers as a base material; (2) carrying out foaming treatment on the covalent cross-linking mixture by using a surfactant; (3) carrying out circulating freezing and thawing treatment on the covalent cross-linking mixture subjected to foaming treatment; and (4) performing normal-pressure drying on the covalent cross-linking mixture subjected to circulating freezing and thawing treatment to obtain the biomass fiber aerogel. The biomass fiber aerogel material obtained by the invention has high porosity and can effectively adsorb various micro-plastics, and the preparation process used in the invention does not need critical condition drying equipment, so that the preparation cost and period of aerogel are reduced, and the biomass fiber aerogel material has industrial large-scale production potential.

The invention provides a novel crystal form and a novel crystal form APTI-I. The novel crystal form and the novel crystal form APTI-I are radiated by Cu-K alpha, and an X-ray powder diffraction pattern represented by a 2 theta angle has characteristic peaks at 5.0 degrees + / -0.2 degrees, 6.3 degrees + / -0.2 degrees, 7.8 degrees + / -0.2 degrees, 12.2 degrees + / -0.2 degrees and 20.0 degrees + / -0.2 degrees. The crystal form is easy to prepare, high in purity, good in stability, good in solubility in buffer solutions and deionized water solvents with different pH values, and suitable for industrial large-scale production and preparation of pharmaceutical preparations.

The invention discloses a method for preparing a carbon nano tube by rapidly decomposing a waste high-molecular polymer, and belongs to the technical field of nano material preparation. The method comprises the following steps: mixing a waste high-molecular polymer (such as polyethylene, rubber and the like) serving as a carbon source with a metal-based catalyst and a conductive carbon material, sealing the mixture in a reaction container, connecting an external power supply, instantaneously heating to 600-2500 DEG C under the action of current through the Joule heating effect of the conductive carbon material, and reacting for 5-60 seconds to realize the efficient growth of the carbon nanotube. According to the method, the agglomeration of the catalyst is inhibited through the rapid heating and cooling characteristics of Joule heat, the carbon source is promoted to be selectively decomposed into C1-C3 small molecules, and the graphitization degree and diameter uniformity of the carbon nanotubes are remarkably improved. Compared with the traditional method, the method has the advantages of short reaction time (second level), low energy consumption, high product purity, capability of macroscopic preparation and the like, and is suitable for industrial large-scale production.

The invention provides a preparation method of lithium sulfide, and relates to the technical field of lithium sulfide. According to the preparation method of the lithium sulfide, the lithium sulfide is obtained by reducing the sulfur salt component and the lithium sulfide in the atmosphere of the reducing gas, so that the process conditions are relatively mild, and the industrial large-scale production is facilitated.

The invention provides a Ziegler-Natta catalyst silicon-magnesium composite carrier and a preparation method thereof, a continuous phase silicon solution is prepared by using a double template agent, the continuous phase silicon solution is mixed with a cross-linking agent and an initiator to obtain a dispersed phase, the dispersed phase is subjected to two-phase speed regulation mixing through a micro-fluidic chip to finally obtain double emulsion droplets, and then operations such as curing, template agent removal and acid etching are performed to obtain the Ziegler-Natta catalyst silicon-magnesium composite carrier. The preparation method comprises the following steps: preparing a spherical silicon dioxide carrier with more excellent performance, then carrying out magnesium source loading and post-treatment, and finally preparing the Ziegler-Natta catalyst silicon-magnesium composite carrier with monodispersity, hierarchical porous structure (micropore-mesopore-macropore), high loading rate and high mechanical strength, and is suitable for industrial-scale polypropylene catalyst production. The prepared catalyst carrier is more perfect in morphology and more uniform in particle size.

The invention relates to an extraction method for strengthening low-concentration rare earth elements and equipment for implementing the extraction method. The extraction method is a continuous extraction process based on the combination of a microfluid technology and a solvent extraction technology, and efficient enrichment and recovery of low-concentration rare earth elements are realized through combined use of a gas-liquid-liquid three-phase system and an extraction agent. The extraction method provided by the invention has the advantages of high mass transfer efficiency, simple operation, recyclable extraction agent, high extraction efficiency, good stability and the like, and is suitable for enrichment and recovery of low-concentration rare earth elements on an industrial scale under the condition of a large phase ratio (greater than 50).

The invention relates to a multifunctional tandem catalytic process for directly preparing methyl acetate / ethanol from synthesis gas. According to the process, a novel catalyst for preparing dimethyl ether from synthesis gas is prepared by adopting an impregnation method, and after the catalyst is sequentially connected with a dimethyl ether carbonylation catalyst and a hydrogenation catalyst in series, efficient directional synthesis of methyl acetate and ethanol is realized in a double-bed or three-bed sequential filling form. According to the invention, high CO conversion per pass, high methyl acetate selectivity and low acetic acid selectivity can be realized, and the problems of corrosion and difficult conversion of a subsequent hydrogenation system are effectively avoided; the multifunctional catalytic system provided by the invention is simple in preparation method and easy to realize industrial large-scale production.

Systems for manufacturing reverse osmotic desalination membranes are described. The system is for the industrial scale manufacturing of carbon nanotubes supported reverse osmotic desalination membranes. The system overcomes several technological challenges and develops new membranes, improving aspects of membrane manufacturing and performance.

The utility model discloses a liquid-phase synthesis system of lithium sulfide. Comprising a first lithium sulfate dissolving device, a first barium sulfide dissolving device, a chemical combination reaction device, a first separation device and a second separation device, the liquid phase after-treatment unit is used for concentrating, purifying and drying the liquid phase to obtain lithium sulfide, and the solid phase after-treatment unit is used for washing and drying the solid phase to obtain barium sulfate; the first lithium sulfate dissolving device and the first barium sulfide dissolving device are both connected with a raw material inlet of the combination reaction device; and a reaction product outlet of the combination reaction device is connected with the first separation device. The liquid-phase synthesis system of the lithium sulfide has the advantages that products are easy to separate, the purity of the lithium sulfide products is high, the liquid-phase synthesis system of the lithium sulfide is very suitable for industrial-scale production, and the produced high-purity anhydrous lithium sulfide is very suitable for solid-state battery anode materials and has huge potential economic benefits.

The invention relates to the technical field of chemical intermediates, and particularly discloses a preparation method of a givelastat intermediate.According to the preparation method, an initiator compound 5 can be synthesized by adopting cheap 2-hydroxy-6-naphthoic acid (CAS: 16712-64-4, 141 yuan / kg), and the preparation method is different from a method in the prior art. A gemvelastat intermediate compound 4 is synthesized from a compound 5 through a three-step reaction, compared with the prior art, the yield is high, industrial amplification production is more facilitated, in the process of synthesizing a compound 6 from the compound 5, acetonitrile can be adopted as a cyanide source in a reaction system, activated hydroxyl is subjected to a coupling reaction, and the yield is high. In the process of synthesizing a compound 6 from a compound 7 instead of a traditional metal cyanide, or in the process of synthesizing a compound 6 from another compound 5, a cheap cuprous cyanide and cuprous iodide system is adopted for a coupling reaction, and in the process of synthesizing a compound 4 from a compound 7, an acetic acid and sodium triacetoxyborohydride reaction system is adopted, so that the compound 6 is synthesized. And the important intermediate of the givelastat can be obtained with high yield.

This application provides a method for preparing compound I-b or a pharmaceutically acceptable salt thereof, wherein (S)-N-methylamino-1-(2-thiophene)-1-propanol reacts with 4-fluorobenzo[1,3]dioxolane in a system containing sodium hydride and potassium benzoate to obtain compound I-b. This method has short steps, mild reaction conditions, and is simple to operate, making it suitable for industrial scale-up; moreover, the obtained product has high purity and low isomer content.

Typical commercial surface treatments for continuous carbon fibers are often unavailable for discontinuous fibers. As such, there is little variety of chopped fiber surfaces leading to non-ideal coating solutions which result in poor interfacial compatibility between fibers and a composite matrix. A method of applying a highly effective coating using a high throughput technique for chopped carbon fibers. The method provides the ability to tune both the coating thickness and chemical functionality using processing parameters. The coatings are evaluated using X-ray photoelectron spectroscopy (XPS) for uniformity and composition. Using this technique, thermoplastic composites are highlighted showing an increase in interfacial shear strength (IFSS) of 25 MPa. This process shows promise for increasing the throughput of surface treatment of chopped fiber on the industrial scale.

The invention relates to the technical field of production of silicon-carbon negative electrode materials, in particular to a continuous production device and method for preparing a silicon-carbon negative electrode material by taking porous carbon, silane and hydrocarbon gas as raw materials. The device comprises fluidized beds A1 and B1, storage tanks A2, A4, B2 and B4, cyclone separators A3, B3 and C2 and a heat exchanger C1, and stable fluidization and continuous production of materials are realized through the design of the multi-section reducing fluidized bed. The method comprises the following steps: carrying out silane cracking and silicon embedding on porous carbon, carrying out hydrocarbon gas cracking and carbon coating, cooling and separating, and finally obtaining the silicon-carbon negative electrode material with high capacity and high initial coulombic efficiency. The equipment adaptability can be remarkably improved, the service life is prolonged, efficient and continuous production is achieved, and the equipment is suitable for industrial-scale application.

Systems for manufacturing reverse osmotic desalination membranes are described. The system is for the industrial scale manufacturing of carbon nanotubes supported reverse osmotic desalination membranes. The system overcomes several technological challenges and develops new membranes, improving aspects of membrane manufacturing and performance.

The invention discloses a multi-stage fermentation method for improving thallus activity and stability, and particularly relates to the technical field of microbial fermentation. Dynamically dividing a fermentation period into a plurality of metabolic staging sections based on the multi-source physiological characteristic parameter set; constructing a multi-stage environment regulation and control model, taking the optimal control parameter vector of each stage as a control target, combining a real-time feedback signal set, and carrying out environment factor regulation through a model prediction control algorithm; calculating a thallus activity improvement rate and a fermentation stress anomaly index in real time, performing cross-batch correction on the multi-stage environment regulation and control model after fermentation is finished, and outputting an optimized parameter template for next fermentation calling; the dynamic self-adaptive control of the fermentation system can be realized, the thallus metabolism efficiency, the process stability and the fermentation repeatability are improved, and the method is suitable for industrial large-scale microbial fermentation production scenes.

The present invention relates to reactors and reactor components which have good resistance to NH3 and N2 and possibly to H2O at high temperatures and moderate pressures and thus can be used in industrial-scale reactions for the catalytic decomposition of NH3 into N2 and H2.

The present application relates to the technical field of solid-state lithium battery, and particularly relates to a sulfide solid electrolyte stable to lithium metal, a preparation method and application thereof. The sulfide solid electrolyte comprises a core of sulfide solid electrolyte particles and a surface coating material coating the core; the sulfide solid electrolyte particles adopt a sulfide solid electrolyte material stable to lithium metal, and the surface coating material adopts a two-dimensional sheet material capable of reacting with lithium metal in situ to generate a high ionic conductive interface layer. The sulfide solid electrolyte provided by the present application can generate a high ionic conductive interface layer promoting uniform deposition of Li metal in situ during the cycle process of the solid-state lithium battery assembled by the sulfide solid electrolyte, effectively inhibits lithium dendrites during the cycle process of the sulfide-based solid-state lithium battery, and improves the cycle life of the solid-state lithium battery. The material preparation process is simple and easy to operate, the coating material improves the air stability of the modified sulfide electrolyte, and is suitable for industrial scale-up operation.

To provide methods of enhancing the robustness, rapidity, automation, and high-throughput nature of in situ sequencing techniques.SOLUTION: Provided herein are devices, methods and systems for in situ gene sequencing of a target nucleic acid in a cell in an intact tissue. Methods of screening a candidate agent to determine whether the candidate agent modulates gene expression of a nucleic acid in a cell in an intact tissue are also provided herein.SELECTED DRAWING: Figure 1-1

The invention discloses a preparation method of a post-metallocene catalyst. The method comprises the following steps: by taking quinoline 2-formaldehyde and ortho-aminophenol as raw materials, carrying out reflux reaction on the raw materials and a first solvent to prepare a ligand; dispersing a metal chloride in a second solvent, adding a Grignard reagent, and carrying out a reaction at a low temperature to prepare a methylated metal reagent; and adding a ligand into the methylated metal reagent, reacting at room temperature for 10-12 hours, removing liquid in vacuum, adding part of the second solvent again, stirring, filtering after the product is dissolved, and recrystallizing the filtrate to obtain the product, the metallocene catalyst is obtained by firstly preparing the ligand, then preparing the methylated metal reagent, adding the ligand into the methylated metal reagent for reaction, then stirring by using the second solvent, filtering after the product is dissolved, and recrystallizing the filtrate, so that the operation steps are simple, and the preparation of the ligand does not need water-oxygen treatment operation, and is simple and easy to implement; the preparation cost of the post-metallocene catalyst is reduced, and the method is suitable for industrial large-scale production.

The invention discloses preparation and application of probiotic double-layer collards based on a molecular armor technology, different double-layer collard systems are formed on the surfaces of probiotics through the molecular armor technology, and specifically, the probiotics are respectively mixed with chitosan oligosaccharide, gelatin and whey protein isolate according to a certain proportion; and self-assembling is carried out under the driving of intermolecular interaction force to form the nano-scale probiotic single-layer collars. Then, pectin is introduced to coat the surfaces of the single-layer collars respectively, and independent packaging of the double-layer collars system on the single probiotics is achieved. The probiotic double-layer collard prepared by the invention not only can promote the growth and reproduction of the probiotics, but also can improve the survival rate and tolerance of the probiotics under the conditions of pasteurization, freeze-thaw cycle, storage at 4 DEG C and in-vitro simulated gastrointestinal environment. More importantly, the preparation method provided by the invention is simple, convenient to operate, relatively low in cost and suitable for industrial large-scale production.

The invention provides an asphalt-based sodium ion battery negative electrode material and a preparation method thereof, and belongs to the technical field of sodium ion batteries. The asphalt-based sodium ion battery negative electrode material has a pseudo graphite layer structure and a disordered structural domain at the same time. The preparation method of the asphalt-based sodium ion battery negative electrode material comprises the following steps: S1, crushing and screening an asphalt raw material to obtain asphalt precursor powder; s2, performing combined pretreatment on the asphalt precursor powder obtained in the S1 by using air and water vapor at the same time; s3, carrying out post-treatment on the combined pre-treatment product obtained in the S2; and S4, carbonizing the post-treatment product in S3 in an inert atmosphere, and cooling to obtain the asphalt-based sodium-ion battery negative electrode material. The asphalt-based sodium ion battery negative electrode material provided by the invention combines the advantages of soft carbon and hard carbon, and has excellent sodium storage reversible capacity, high rate capability and high initial coulombic efficiency. The preparation method is simple, has controllable conditions, has no special requirements on equipment, and is suitable for industrial large-scale production.

The invention relates to the technical field of synthesis of propargyl chloride, in particular to a synthesis method of propargyl chloride. When 3-chloropropyne is synthesized by a conventional method, the yield is difficult to reach 90% or above. In order to solve the technical problems, the invention provides the synthesis method of the propargyl chloride, and propargyl alcohol and hydrogen chloride are subjected to substitution reaction in an organic solvent to generate the 3-propargyl chloride under the action of a closed reactor and a catalyst. According to the method for synthesizing the 3-chloropropyne, the yield of the 3-chloropropyne is larger than or equal to 90%, and the generation amount of by-products is smaller than 5%. The by-product hydrogen chloride is directly used as a synthesis raw material, so that the raw material cost is remarkably reduced. The method is mild in reaction condition, low in equipment investment and suitable for industrial amplification.

The invention provides a streptomyces hygroscopicus engineering strain as well as construction and application thereof, and relates to the technical field of biology, the engineering strain takes streptomyces hygroscopicus CL-1 as a starting host and is obtained by heterologous expression of an epsilon-polylysine synthetase encoding gene pls, and the nucleotide sequence of the epsilon-polylysine synthetase encoding gene pls is shown as SEQ ID NO.1. Streptomyces hygroscopicus CL-1 is used as a host, the epsilon-polylysine synthetase coding gene derived from streptomyces albus is subjected to heterologous expression, the obtained recombinant strain has high epsilon-polylysine production capacity, and under the optimized fermentation condition, the yield of epsilon-polylysine is 0.87 g / L, and industrial scale production requirements are met. Meanwhile, the broad-spectrum antibacterial activity to various plant pathogenic fungi and common bacteria, including colletotrichum gloeosporioides, fusarium oxysporum, phytophthora capsici and the like, is also remarkably improved. Therefore, the streptomyces hygroscopicus has important application in the aspects of production of epsilon-polylysine, prevention and control of pathogenic microorganisms, preservation and the like, and the industrial and agricultural utilization potential of the streptomyces hygroscopicus is expanded.

The present invention relates to a sulfuration type hydrocracking catalyst and a preparation method and application thereof, and relates to the technical field of catalysts, the preparation method of the sulfuration type hydrocracking catalyst comprises the following steps: mixing a Y molecular sieve, amorphous silica-alumina, macroporous pseudo-boehmite, microporous pseudo-boehmite and sesbania powder, and spraying a nitric acid aqueous solution, sequentially rolling to obtain an extrudable paste, extruding into strips, drying and roasting to prepare a catalyst carrier; soluble tungsten salt and soluble nickel salt are dissolved in water to prepare a uniform solution, and steeping liquor is obtained. The invention provides a sulfuration type hydrocracking catalyst which is completely sulfurized and has fully exposed active sites, and a preparation method thereof. The sulfuration type hydrocracking catalyst is used in the field of distillate hydrocracking. The catalyst adopts a mild vulcanization method, the vulcanization process does not pass through a metal oxidation state, sulfur-containing tail gas is not generated, and the preparation method is simple, low in cost and environment-friendly, meets the green development requirement and is suitable for industrial amplification application.

The invention relates to the technical field of chemical catalysis, in particular to a polyether polymerization catalyst which comprises the following components: double metal cyanide (DMC) of which the average particle size is 20-50nm, a cocatalyst of which the addition amount is 3-5% of the total mass of the catalyst, a Lewis acid-alkali pair catalyst of which the addition amount is 3-5% of the total mass of the catalyst, and a dispersing aid of which the addition amount is 1-2% of the total mass of the catalyst, the preparation method comprises the following steps: preparing a granular catalyst suitable for an industrial scale through a spray drying molding technology, improving the catalytic efficiency by 20% or more and reducing side reactions by 30% or more under the condition of 60-80 DEG C, and the generated polyether has narrow molecular weight distribution (PDilt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt and PDIt); 1.2) and a low degree of unsaturation (lt; the quality of the product is obviously improved, and the product is suitable for high-end application of polyurethane, lubricating oil and green chemicals.

The present invention discloses a method for an electrocatalytic production of formic acid in a single-chamber electrolysis system, belonging to the field of electrocatalysis. The cathode electrode and the anode electrode of the present invention are arranged in the single-chamber electrolysis system. The anode electrode is a self-supporting electrode loaded with a nickel-based layered double hydroxide catalyst, and the cathode electrode is a gas diffusion electrode sprayed with a copper-based, bismuth-based, tin-based or indium-based metal or alloy catalyst. In the examples provided by the present invention, a nickel foam electrode with electrochemically activated surface-grown NiV layered double hydroxide is used as the anode electrode for catalyzing the oxidation of glycerol to produce formic acid, and conductive carbon black loaded with Bi nanoparticles is sprayed onto the gas diffusion electrode as the cathode electrode for catalyzing the electrochemical reduction of CO2 to produce formic acid. The present invention realizes the simultaneous production of formic acid at the cathode and the anode in the single-chamber electrolysis system, greatly improves the energy efficiency of formic acid production, reduces the cost of the electrochemical reactor, and improves the stability of the reaction device. The scaled-up single-chamber electrolysis system provides a new idea for the industrial-scale production of formic acid.