The invention relates to negative-ion, far-infrared, antibacterial and anti-mite compound polyester fibers and a manufacturing method thereof. The compound polyester fibers are added with a negative-ion additive, a far-infrared additive and an antibacterial and anti-mite additive, wherein the negative-ion additive, the far-infrared additive and the antibacterial and anti-mite additive respectively account for 2%, 5% and 6% by mass in the compound polyester fibers; the negative-ion additive comprises an additive carrier and tourmaline negative-ion powder; the far-infrared additive comprises an additive carrier, Tai Chi stone powder, ZrO2 nano-powder, nano-silicon dioxide, nano-aluminum oxide, nano-manganese oxide and nano-calcium oxide; the antibacterial and anti-mite additive comprises an additive carrier, nano-Cu-ZnO compound particles, nano-titanium dioxide, nano-zinc oxide and nano-silicon dioxide; and the additive carrier is TiO2 hollow spheres.