5results about How to "Long-term release" patented technology

The present application provides a kind of textile fiber coated with essential oil and a preparation method thereof, relating to the technical field of textile fiber.The textile fiber coated with essential oil of the present application, the body of textile fiber is distributed with at least one closed hollow structure in the position close to surface, the closed hollow structure is coated with essential oil, and the depth of closed hollow structure along the cross section of textile fiber is not less than 1 / 20 of the diameter of textile fiber.The present application can achieve good coating performance of textile fiber on essential oil without using microcapsules coated with essential oil, and realize long-acting release of essential oil.

This invention discloses a starch-plant polyphenol cocrystal, its preparation method, and its application in functional foods, relating to the field of functional food technology. The preparation method includes: S1, mixing starch and plant polyphenols uniformly to obtain a mixture; S2, adding the mixture to a low-temperature impact mill, adding grinding media, and introducing an inert gas into the low-temperature impact mill to subject the mixture to impact treatment, obtaining a cocrystal complex; S3, purifying and freeze-drying the cocrystal complex to obtain the starch-plant polyphenol cocrystal. This invention innovatively uses wheat starch and proanthocyanidins to form a cocrystal structure, resulting in a simpler and more efficient preparation process, eliminating the need for complex physical field treatments or multiple freeze-drying steps, and maximizing the preservation of polyphenol activity. The cocrystal structure endows the carrier with excellent sustained-release performance, enabling long-term release of polyphenols in functional food applications, solving the problems of unstable loading rates and poor sustained-release effects in existing technologies.

A kind of gel material for reducing bladder stone formation and its preparation method and application, the raw materials of the gel material include temperature-sensitive component Pluronic F127, photo-crosslinking component methacrylated gelatin and active functional ingredient cerium dioxide nanoparticles.The gel material is liquid at low temperature, which is convenient for perfusion into bladder through catheter;It quickly changes into physical gel at body temperature, realizing in-situ forming;Then it occurs photo-crosslinking through ultraviolet irradiation, forming chemical crosslinking gel with high mechanical strength and good stability, which can resist urine flushing and realize long-term residence.Loaded cerium dioxide nanoparticles continuously remove reactive oxygen species in stone formation microenvironment by simulating catalase and superoxide dismutase activity, thereby inhibiting the nucleation, growth and aggregation of crystals.The material has excellent biocompatibility, simple preparation method, can significantly reduce bladder stone formation, and has broad application prospect in preventing postoperative recurrence of bladder stone and conservative treatment.

This invention discloses the application of Z944 in the preparation of drugs for treating knee osteoarthritis. Z944 can simultaneously promote the repair of knee cartilage and inhibit neuropathic pain, overcoming the shortcomings of existing KOA therapies, such as single target, limited efficacy, and inability to block the core pathological cycle of the disease. The mechanism of action of Z944 lies in its ability to simultaneously inhibit abnormal discharge of pain neurons and block the catabolism signals of chondrocytes, thereby fundamentally intervening in the vicious cycle of cartilage degeneration and pain transmission in knee osteoarthritis. Compared with existing therapies that target only a single pathological link, this invention achieves a synergistic therapeutic effect greater than the sum of its parts (1+1>2). Its efficacy stems from blocking the core mechanism of the disease, thus being more fundamental and lasting.

The invention relates to a preparation method of a triptolide-polypeptide conjugate and a long-acting hydrogel preparation of the triptolide-polypeptide conjugate, the triptolide-polypeptide conjugate is formed by coupling triptolide and a polypeptide sequence with assembly performance through a degradable group, and the triptolide-polypeptide conjugate is obtained. The degradable group comprises a carboxylic ester bond formed by a hydroxyl group of triptolide and a carboxylic acid derivative. An alkyl chain can be further introduced into the N end of the polypeptide sequence with the self-assembly performance, so that the stability of an assembly is improved, and the drug release period is regulated and controlled through the length of the alkyl chain. The triptolide-polypeptide conjugate is self-assembled in an aqueous medium to form a nanostructure, and the nanostructure is subjected to solution-gel conversion under physiological conditions to form a hydrogel preparation. The hydrogel preparation can form a medicine storage cavern at a focus part, long-term and controllable medicine release is realized, and the safety of the medicine is improved.