97results about How to "Long-term release" patented technology

This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.

The invention discloses a trace element-doped porous calcium carbonate ceramic, and a preparation method and application thereof, belonging to the field of medical materials for bone repair. The preparation method disclosed by the invention comprises the following steps: doping Mg, Sr, Zn, Si, Cu and other trace elements in a human body into calcium carbonate through a chemical precipitation method, or doping trace elements into low-temperature phosphate bioglass used as a sintering binder, uniformly mixing the trace element-doped calcium carbonate powder, the glass binder and pore forming agent, then forming, performing isostatic pressing treatment, sintering, and removing the pore forming agent to obtain the trace element-doped porous calcium carbonate ceramic. The trace element-doped porous calcium carbonate ceramic prepared by the invention has high strength and porosity, controllable degradation rate, long-term slow release of the doped trace element ions and favorable bone conductibility and inductivity, and is a novel artificially synthesized bone repair material.

The invention discloses a preparation method of injectable chitosan grafted cyclodextrin compound drug-carrying hydrogel. The preparation method comprises the steps of carrying out amination and hydroformylation on cyclodextrin, reacting by virtue of hydroformylated cyclodextrin with chitosan so as to obtain chitosan grafted cyclodextrin, soaking molecules of obtained chitosan grafted cyclodextrin into medical liquid, uniformly stirring, filtering, carrying out freeze drying so as to obtain drug-carrying chitosan grafted cyclodextrin, adding drug-carrying chitosan grafted cyclodextrin into a chitosan water solution, adding beta-sodium glycerophosphate, so as to obtain the injectable chitosan grafted cyclodextrin compound drug-carrying hydrogel. The preparation method has the beneficial effects that reaction conditions are mild, and the operation is relatively simple and convenient; the stability of a drug concentration in a gel system of the prepared hydrogel can be maintained for a long time, and a drug can be effectively and controllably released for a long time, so that the utilization rate of the drug is increased; and the preparation method has relatively wide application prospects.

The invention provides a nanoparticle preparation method. According to the preparation method, a first microemulsion is mixed with a second microemulsion. The first microemulsion contains a surfactant, an organic solvent and a first reactant aqueous solution. The second microemulsion contains a surfactant, an organic solvent and a second reactant aqueous solution. Precipitates can be formed afterthe first reactant contacts with the second reactant. The surfactant in the first microemulsion is the same as that in the second microemulsion, and the surfactant is a mixture of an oil-soluble polyoxyethylene-polyoxypropylene segmented copolymer surfactant and a water-soluble polyoxyethylene-polyoxypropylene segmented copolymer surfactant or a cationic surfactant of cetyl trimethyl ammonium bromide and the like. The nanoparticles provided by the invention have good safety and can obviously raise gene transfection level and promote proteins or drugs to enter into cells.

The invention provides albumin hydrogel. The albumin hydrogel is prepared by mixing albumin, a cross-linking agent and a solvent, the cross-linking agent comprises a repeating unit having a structureof formula (I) and an end group having a structure of formula (II). The invention develops the albumin hydrogel which is rapid in crosslinking, low in gelatinization concentrating and free of biotoxicity, and the albumin hydrogel is applied to the fields of cell culture, tissue engineering and drug delivery. Besides, as a good paclitaxel topical treatment drug carrier, the albumin hydrogel overcomes the defect of poor paclitaxel solubility, polyoxyethylene castor oil with biotoxicity is not introduced, and compared with a systemic preparation, the albumin hydrogel has the advantages that the administration frequency is effectively reduced, the drug concentration at a tumor is increased, and the systemic toxicity is reduced. Nanoparticles wrapping paclitaxel are used as gel forming components of the gel, so that uniform distribution of the paclitaxel in the gel can be realized, and stable and continuous release is realized.

The invention discloses a special organic fertilizer for organic oil tea. The special organic fertilizer is prepared from the following components in percentages by mass: 30-55% of compost, 5-15% of peat, 15-30% of potassium magnesium sulfate, 9-17% of powdered rock phosphate, 0.5-2% of borax, 0.5-1% of a seaweed extraction liquid and 5-15% of clay. The special organic fertilizer disclosed by the invention not only can provide crops with nutrients directly, but also can improve the cold resistance of the oil tea obviously, reduce the flower and fruit falling rates, reduce the plant diseases and insect pests and improve the stress resistance of plants, so that the crops bloom better and bear more fruits, a lot of nutrients are absorbed in a flowering and fruit-bearing later period, a purpose of bearing more fruits to promote production is achieved, the output of the oil tea is improved obviously, and a purpose of production and yield increase is achieved; moreover, the special organic fertilizer which can be used as a soil improver improves the organic matters of soil, regulates the pH value of the soil and improves the granular structures of the soil, and achieves the purposes of improving the soil and increasing the fertilizer efficiency.

A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, electrodes and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.

The invention relates to a venlafaxine hydrochloride sustained-release capsule and a preparation method thereof, wherein the sustained-release capsule is composed of a sustained-release pillet and a capsule shell; the substrate of the sustained-release pillet is an inert pillet core; and a fluidized bed respectively comprises a medicine layer, an isolation layer and a sustained-release layer. Compared with the traditional rolling extrusion method, the preparation method disclosed by the invention is simple; and simultaneously, because of optimal selection of a coating layer, long-term release of medicines can be realized.

The invention belongs to the field of biological materials for dental healthcare, and relates to a root face protection material composition for dentistry. The root face protection material composition comprises a substrate material and a reinforcing material, wherein the substrate material comprises the following components in parts by weight: 1 to 10 parts of polymeric monomers, 1 to 20 parts ofadhesive additive, 0.01 to 10 parts of light initiator, and 50 to 99 parts of solvent; and the reinforcing material comprises the following components in parts by weight: 50 to 100 parts of polymericmonomers, 0.01 to 10 parts of light initiator, and 0 to 50 parts of inorganic filler. By adopting the root face protection material composition, a root face protection material has the following advantages: a) after the curing, people can take food immediately without worrying about the problems such as eating, tooth brushing and the like; b) the root face protection material is in a white or semi-transparent state, so that the attractive appearance of teeth is not influenced; and c) by adding a given amount of inorganic filler, the root face protection material has good strength and can remain on the tooth for a longer time.

The invention discloses a novel environmentally-friendly wood-plastic floor material and a preparation method thereof, and relates to the technical field of coatings. The material comprises, by weight, 15-25 parts of polyacrylic resin, 12-20 parts of polyamide resin, 20-35 parts of vegetable fibers, 8-13 parts of ceramic fibers, 5-12 parts of seashell powder, 7-15 parts of diatomaceous earth, 4-10parts of glass beads, 5-12 parts of expanded perlite, 10-18 parts of silica gel particles, 4-9 parts of nanometer titanium dioxide, 3-7 parts of nanometer magnesium oxide, 2-5 parts of nanometer molybdenum oxide, 2-5 parts of nanometer titanium nitride, 3-7 parts of peppermint essential oil, 4-7 parts of activated carbon, 5-10 parts of a plant regulator, 1.3-2.5 parts of a foaming agent, 2.4-3.8parts of a flame retardant, 1.4-2.6 parts of a plasticizer, 1.8-3.2 parts of an anti-aging agent and 30-45 parts of a 25 wt% ethanol solution. The material has the advantages of good aging resistance,no formaldehyde substances, greenness and environmental protection.

The invention relates to a konjac glucomannan aqua filter core and a preparation method therefor. The preparation method for the konjac glucomannan aqua filter core comprises the steps of preparing konjac fibers, preparing konjac glucomannan gel microspheres, preparing nutritional supplement containing konjac glucomannan gel microspheres and preparing the filter core. The konjac glucomannan aqua filter core disclosed by the invention adopts konjac as a main raw material and plays a role by using the adsorption performance of the konjac fibers and the konjac glucomannan gel microspheres and the sustained release performance of the microspheres. The konjac fibers can be used for purifying water, and the konjac glucomannan gel microspheres can be used for filtering out most microorganisms in the water, so that microbiocides are not required to be used to a large extent; and the nutritional supplement containing konjac glucomannan gel microspheres can enable nutrients to be released in a long-term, stable and continuous manner so as to guarantee human body absorption efficiency. A nutritional supplement contains the ingredients, i.e., calcium carbonate, ferrous fumarate, zinc sulfate, sodium selenite, copper sulfate, manganese sulfate, chromium picolinate and the like and can be used for supplementing human required essential trace elements such as calcium, ferrum, zinc, selenium, copper, manganese, chromium and the like.

The present invention discloses one kind of washing method with automatically controlled sterilization and the washing machine therewith. The washing machine includes one sterilizer comprising one container capable of being closed, one tray for the container to set on and one casing to holding the container and the tray and capable of being closed to form one integral. The sterilizer is set in the water supplying path of the washing machine, and inside the container is slow releasing functional composition for sterilizing. When water flows through, proper amount of functional composition is dissolved into water to sterilize and deodorize.

The invention discloses a composite phosphorus removal material based on collophanite and an application method of the composite phosphorus removal material. The composite phosphorus removal materialis a granular material prepared by taking collophanite, a material rich in active magnesium oxide and calcium sulfate as main raw materials. The obtained material is used as a filtering and percolating medium material for phosphorus removal, is used for deep phosphorus removal of phosphorus-rich water such as domestic sewage, black and odorous water bodies and farmland water, and has the advantages of wide raw material source, low material preparation cost and good phosphorus removal effect.

The invention discloses polymer composite microspheres, and a preparation method and application thereof, and relates to the technical field of microsphere materials. The polymer composite microspheres comprise macromolecular compounds, albumin and protein binding type functional molecules, wherein the macromolecular compounds are used for coating the albumin and the protein binding type functional molecules. According to the preparation method of the polymer composite microspheres, the macromolecular compounds are used for coating the albumin and the protein binding type functional moleculesto form a microsphere structure, through the effects of the albumin and the effects of the protein binding type functional molecules, the effect of slowly releasing the protein binding type functionalmolecules for a long term can be achieved, and the sudden release effects of the protein binding type functional molecules can be alleviated. The polymer composite microspheres can be applied as slowrelease functional materials, and can be particularly used as drug bearing microsphere for slow release of drugs.

The invention provides crisaborole temperature-sensitive gel as well as a preparation method and application thereof. The crisaborole temperature-sensitive gel is prepared from the following raw material components in percentage by mass: 1 to 2 percent of crisaborole, 17 to 23 percent of poloxamer, 0.1 to 1 percent of modified cellulose, 5 to 15 percent of propylene glycol and/or glycerol, 5 to 10percent of ethanol, 0.01 to 0.02 percent of butylated hydroxytoluene and the balance of water. The crisaborole temperature-sensitive gel disclosed by the invention has the advantages that injection implantation and long-term drug release can be achieved; the drug can play a good slow-release effect in a human body by adopting a percutaneous drug delivery mode; in addition, drug extravasation canbe prevented and long-term drug release is achieved.

The invention provides a photocatalyst coating material. The photocatalyst coating material comprises a sizing agent and a basic material, by weight, the sizing agent is mainly prepared by the following components of 40-50 parts of nano titania, 120-130 parts of titanium dioxide, 100-120 parts of nano silica flour, 30-40 parts of anion powder, 150-160 parts of extender pigment, 11-24 parts of sizing auxiliary agents and 230-250 parts of water; the basic material is mainly prepared by the following components of 260-280 parts of external wall emulsion and 44-74 parts of basic material auxiliary agent. The photocatalyst coating material and the preparation method thereof have five unique functions that 1, the ultra-low VOC and the excellent air purifying function are achieved, and formaldehyde, ammonia and benzene and other harmful gases in air can be purified; 2, the specific antibacterial and antifungal effects are achieved, and the antibacterial rate is above 98%; 3, anions can be released for a long time; 4. ultra-strong scrubbing resistance and aging resistance performances are achieved, and phenomena of pulverization, cracking and color fading and color changing are not prone to occurring; 5, the prominent protective capability is achieved, and fine cracks can be covered.

The invention provides a preparation method for refreshing and restoring preserved flowers. The preparation method comprises the following steps: immersing fresh sliced flowers in a decoloring and dewatering solution for 1-12 hours; and immersing the fresh sliced flowers into a microcapsule dispersing solution for 4-20 hours, and obtaining the refreshing and restoring preserved flower after drying. The microcapsule dispersing solution is prepared according to the following steps: uniformly dispersing 20-30 parts by weight of refreshing and restoring microcapsules in 80-150 parts by weight of waterborne polyurethane by a dispersing agent, and adding 0.5-1.5 parts by weight of a coloring material to obtain the microcapsule dispersing solution. Compared with the prior art, the preparation method disclosed by the invention has the advantages that the refreshing and restoring microcapsules are used as main components; as the microcapsules are excellent in slow release effect, essential oil can be continuously released for a long time; therefore, the preserved flowers have refreshing and restoring effects and also a slow release effect, are safe and effective, keep the beautiful appearance of a real flower and can beautify the environment.

The invention relates to the technical field of fertilizer processing, in particular to a preparation method of an elemental sulfur based ammonium phosphate slow release fertilizer. The preparation method comprises the following steps of preparation of sulfur sol, mixing, pelleting, coating and cleaning. The preparation method provided by the invention is simple in technology and safe to operate;a prepared coated elemental sulfur based ammonium phosphate product well controls the release rate of nitrogen, phosphorus and sulfur, realizes long-acting release of nutrient elements; and in addition, the contained sulfur and silicon components can promote absorption of other nutrient elements and improve the stress resistance growth of crops.