82results about How to "Achieve controlled release" patented technology

The invention discloses a dependency-free anti-aging sleep-aiding preparation and a preparation method thereof, and relates to the technical field of preparations, the anti-aging sleep-aiding preparation comprises an ellipsoidal shell and an ellipsoidal core wrapped in the ellipsoidal shell, the ellipsoidal core comprises an anti-aging agent layer, a water absorption expansion layer and a sleep-aiding agent layer which are stacked in sequence, the water absorption expansion layer protrudes at the two ends of the ellipsoidal core to form small water diversion columns; small water inlet holes are formed in the two ends of the ellipsoidal shell and are connected with small water diversion columns; a plurality of first release holes and a plurality of second release holes are formed in the circumferential surface of the ellipsoidal shell, the plurality of first release holes lead to the anti-aging agent layer, and the plurality of second release holes lead to the sleep aid layer. Through the special structural design of the ellipsoidal shell and the ellipsoidal core, isolated coexistence of anti-aging and sleep-aiding components and controllable release of the anti-aging and sleep-aiding components are achieved, so that the dual effects of anti-aging and sleep-aiding can be achieved, and it is guaranteed that the drug effect is continuously exerted.

The invention discloses injectable hydrogel for eye drug sustained release and a preparation method and application thereof.The method comprises the steps that a NaIO4 solution is dropwise added into a hyaluronic acid solution, after the reaction is conducted in a dark place at the room temperature, ethylene glycol is added for continuous reaction, and formylated hyaluronic acid is prepared; the preparation method comprises the following steps: adding adipic dihydrazide into a carboxymethyl cellulose solution, uniformly stirring at room temperature, adding 1-hydroxybenzotriazole and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and stirring to react, so as to prepare aminated carboxymethyl cellulose; and mixing the PBS solution of aminated carboxymethyl cellulose with the PBS solution of formylated hyaluronic acid, uniformly stirring, adding a to-be-carried drug and a FeCl3 solution, and carrying out a reaction to prepare the injectable hydrogel for sustained release of the eye drug. The hydrogel is convenient to use and high in gelation rate, effectively realizes controllable release of drugs, and has a wide application prospect in the field of biological medicines.

The invention discloses a zero-valent iron-carbon source-anaerobic digestion bacterium sustained-release microcapsule as well as preparation and application thereof, and belongs to the technical field of wastewater treatment. The preparation method comprises the following steps: S1, preparing a biochemical mixed embedding liquid containing an embedding material and a gel; s2, adding the biochemical mixed embedding liquid obtained in the step S1 into a cross-linking liquid, and performing cross-linking treatment to obtain the zero-valent iron-carbon source-anaerobic digestion bacterium sustained-release microcapsule, in the step S1, the embedding material comprises zero-valent iron, anaerobic digestion bacteria and a carbon source, and the zero-valent iron, the anaerobic digestion bacteria and the carbon source are jointly fixed inside and on the surfaces of the porous particles, so that loss of the zero-valent iron and the anaerobic digestion bacteria is effectively prevented, and passivation of the zero-valent iron is reduced; moreover, the carbon source is embedded in the immobilized particles, so that slow release of the carbon source is effectively realized, and dynamic balance of carbon source supply and biological requirements is realized.

The invention relates to the field of hydrogel materials, in particular to a hydrogel dressing as well as a preparation method and application thereof. The deferoxamine mesylate is loaded on the gelatin microsphere material constructed by the gelatin and the genipin, so that the loading dispersion of the deferoxamine mesylate can be benefited, and the added gelatin can be in contact with matrix proteinase-9 in a diabetic foot ulcer microenvironment for degradation so as to induce the release of the deferoxamine mesylate. A first cross-linked network is formed by the 3-carboxyphenylboronic acid modified chitosan and the oxidized hyaluronic acid, and the gelatin microsphere material loaded with the deferoxamine mesylate and the epigallocatechin gallate are coated with the first cross-linked network. The hydrogel dressing realizes controllable release of the deferoxamine mesylate and the epigallocatechin gallate, so that the technical problem of uncontrollable release of the deferoxamine mesylate is solved.

The invention belongs to the technical field of biological medicines, and particularly relates to sodium pyruvate sustained-release gel nanoparticles based on redox response as well as a preparation method and application of the sodium pyruvate sustained-release gel nanoparticles. The preparation method comprises the following steps: adding modified gellan gum containing sulfydryl and catechol groups, phenylboronic acid modified gellan gum and sodium pyruvate into water to obtain a mixed solution; under the protection of inert gas, divalent metal salt and potassium persulfate are added into the mixed solution, stirring is performed for 3-5 h, after the reaction is finished, centrifugation is performed, precipitates are collected, washed and dried, and the composite material is obtained. Experimental results show that the sodium pyruvate sustained-release gel nanoparticles prepared by the invention can realize controlled release of drugs, reduce toxic and side effects caused by burst release of the drugs, improve the curative effect of the drugs and improve the bioavailability.

The invention relates to the technical field of organic polymer materials, and discloses a hyperbranched hemicellulose polymer as well as a preparation method and application thereof. The hyperbranched hemicellulose polymer provided by the invention has a structural formula as shown in a formula I, and the degree of substitution is 0.58-0.80. The invention provides a method for preparing hyperbranched hemicellulose-based hydrogel by taking hemicellulose extracted from waste liquid as a raw material to synthesize a hyperbranched hemicellulose polymer and taking the hyperbranched hemicellulose polymer as a skeleton. The preparation method provided by the invention has the advantages of simple process, abundant raw material sources, low price, greenness, environmental protection and the like. The prepared hyperbranched hemicellulose-based hydrogel is not only biodegradable, but also has good biocompatibility and water solubility. The hyperbranched hemicellulose hydrogel drug-loading system has good swelling reversibility, pH responsiveness and temperature responsiveness, the selection range of loaded drugs is wide, and the hyperbranched hemicellulose hydrogel drug-loading system has wide application potential.

The invention relates to self-healing hydrogel for preventing intrauterine adhesion and a preparation method and application thereof. The preparation method comprises the following steps: dissolving hyaluronic acid in ultrapure water, then adding EDC and NHS, adjusting the pH value, then adding cysteamine hydrochloride, and after the reaction is finished, dialyzing and freeze-drying to obtain sulfydryl modified hyaluronic acid marked as HASH; dissolving the HASH in ultrapure water, then adding EDC and NHS, adjusting the pH value, then adding dopamine hydrochloride, and after the reaction is finished, dialyzing and freeze-drying to obtain sulfydryl and dopamine modified hyaluronic acid which is marked as DAHASH; carrying out surface sulfhydrylation treatment on the mEXO to obtain an engineered exosome which is marked as SmEXO; and respectively dissolving the DAHASH, the SmEXO and silver nitrate in ultrapure water, and then mixing to obtain an exosome-hydrogel system which is marked as DAHASH (at) SmEXO. The hydrogel for preventing intrauterine adhesion has a self-healing characteristic, is suitable for a special structure of an intrauterine, can be anchored on a wounded surface of a uterus, is continuously adhered to an endometrium for slowly releasing SmEXO, and creates a good condition for long-term repair of the endometrium.

The invention relates to the technical field of biological materials and tissue engineering, in particular to a three-dimensional scaffold with biological energy activity and a preparation method of the three-dimensional scaffold. The preparation method comprises the following steps: carrying out prepolymerization reaction on an intermediate product of tricarboxylic acid circulation and trihydric alcohol to obtain a prepolymerization product; mixing a polar solvent and the prepolymer to obtain a prepolymer solution; the sacrificial template, isocyanate and the prepolymer solution are mixed to remove the polar solvent, and printing slurry is obtained; carrying out 3D printing on the printing slurry under a preset printing condition so as to carry out primary cross-linking molding to obtain a crude three-dimensional bracket; carrying out secondary cross-linking molding on the crude three-dimensional bracket to obtain the three-dimensional bracket; wherein the weight m1 of the sacrificial template and the weight m2 of the prepolymer product in the prepolymer solution meet the relational expression: m1: m2 = 2: 1. According to the preparation method, the adjustability and uniformity of the pore structure of the three-dimensional scaffold with the biological energy activity can be improved at the same time, and a new material can be provided for clinical treatment of the orthopedics department.

The invention relates to the field of electronic cigarette liquid, and provides high-stability nicotine salt, a preparation method and electronic cigarette liquid thereof, and the nicotine salt is prepared from the following components in parts by weight: 40-60 parts of nicotine, 10-18 parts of organic acid, 3-7 parts of gallic acid grafted chitosan, 4-8 parts of a tea polyphenol / cyclodextrin inclusion compound, 2-6 parts of vesicle coated anthocyanin and 40-60 parts of propylene glycol. The preparation method of the nicotine salt comprises the following steps: mixing organic acid and propylene glycol, heating in a water bath, and stirring to prepare a uniform solution; adding nicotine into the solution, heating and strongly stirring to prepare a nicotine solution; and then adding gallic acid grafted chitosan, a tea polyphenol / cyclodextrin inclusion compound and vesicle coated anthocyanin, uniformly stirring, and freeze-drying to obtain the high-stability nicotine salt. The gallic acid grafted chitosan, the tea polyphenol / cyclodextrin inclusion compound and the vesicle coated anthocyanin solve the problems of insufficient stability and inoxidizability of nicotine salt.

The invention discloses a pyriproxyfen microcapsule suspending agent. The pyriproxyfen microcapsule suspending agent is prepared from the following raw materials in percentage by weight: 8 to 12 percent of pyriproxyfen, 1 to 3 percent of isocyanate, 0.1 to 0.5 percent of polyamine and the balance of deionized water. Compared with the traditional dosage form, the pyriproxyfen microcapsule suspending agent has the advantages that the toxicity of aquatic organisms can be obviously reduced; the field dosage can be greatly reduced, the environmental pollution and pesticide residues are effectively reduced, and the production and use cost is reduced; the dosage form of the microcapsule suspending agent accords with the trend of future agricultural environmental protection development; the smell can be reduced, the pesticide effect is improved, and the lasting period is prolonged.

The invention discloses injectable and degradable composite drug-loading hydrogel as well as a preparation method and application thereof. The injectable and degradable composite drug-loading hydrogel comprises sodium alginate hydrogel, piezoelectric nanofibers and triamcinolone acetonide and / or ropivacaine, wherein the piezoelectric nanofibers and the triamcinolone acetonide and / or the ropivacaine are loaded on the sodium alginate hydrogel; the piezoelectric nanofibers are poly-L-lactic acid nanofibers. Through the synergistic effect of controllable release of the medicine and piezoelectric stimulation, the dual effects of continuous analgesia and neural restoration are achieved in the PHN treatment process, more effective treatment selection is provided for a PHN patient, complications caused by a traditional implantable electrode can be avoided, a more minimally invasive, convenient and safe treatment mode can be provided for the patient, and the treatment effect is good. And a theoretical basis is provided for future clinical practice.

The invention belongs to the technical field of preparation of nano functional materials, and provides a difunctional nanosheet as well as a preparation method and application thereof. On the basis of two-dimensional layered double-metal oxides (LDHs), magnesium-aluminum hydrotalcite (MgAl-LDH) is prepared as a main body laminate, and bioactive components Ce < 3 + > and Sr < 2 + > are introduced into the main body laminate, so that the bifunctional nanosheet capable of accurately and efficiently removing ROS and promoting angiogenesis is developed; wherein due to the existence of Ce < 3 + > and Sr < 2 + >, the nano-sheet has the activity of superoxide dismutase and the characteristic of promoting vascular regeneration at the same time, active sites fully exposed on the surface of the nano-sheet can effectively remove ROS and regulate an anoxic microenvironment, meanwhile, the nano-sheet responds to an ischemic acid microenvironment to release Sr < 2 + >, proliferation and migration of endothelial cells are promoted, and angiogenesis is facilitated. The MgSrCeAl-LDH nanosheet disclosed by the invention is used for treating the MIRI, and the treatment effect is remarkable.

The invention relates to the technical field of antibacterial materials, and provides a light-enzyme-heat synergistic antibacterial nano composite material and a preparation method thereof.The preparation method comprises the steps that 1, a copper-based chalcogenide with a plasma resonance effect serves as a structural template, a transition metal oxide intermediate layer and a bismuth oxyhalide epitaxial layer are sequentially constructed on the surface of the copper-based chalcogenide with the plasma resonance effect through a step-by-step continuous solvothermal method, and the copper-based chalcogenide with the plasma resonance effect serves as the structural template; forming a core-shell heterojunction with Z-type energy band matching; (2) pre-assembling a natural enzyme and a monatomic nano-enzyme in a buffer system to form a composite catalytic unit with an electron transfer channel; and (3) by taking the core-shell heterojunction as a polymerization core, under the precise temperature control condition of 0-10 DEG C, initiating active free radical polymerization through an interface, constructing a thermal response polymer shell layer on the surface of the heterojunction, and encapsulating the composite catalytic unit in a functional microdomain of a polymer network in situ. The anti-bacterial fabric can achieve a better synergistic anti-bacterial effect.

The invention provides a multifunctional fertilizer and a preparation method thereof, and belongs to the technical field of fertilizer production. The multifunctional fertilizer provided by the invention is prepared from 10 to 30 percent of a material A, 20 to 40 percent of a material B, 30 to 50 percent of a material C, 1 to 2 percent of Span-80, 4 to 5 percent of Tween-80, 1 to 2 percent of white carbon black, 1 to 3 percent of magnesium aluminum silicate, 0.01 to 0.15 percent of xanthan gum, 0.03 to 0.05 percent of Kathon, 0.004 to 0.006 percent of a de-foaming agent and the balance of de-ionized water, wherein the material A comprises turf, a functional substance, calcium acetate and alkyl glycoside; the material B comprises an active strain and an auxiliary agent; and the material C comprises vitamin E, methyl esterified soybean oil, isocyanate, a fatty alcohol ether phosphate solution, EO-PO block polyether, a polyvinyl alcohol solution, ethylene glycol and formaldehyde. According to the invention, by adjusting the formula composition and the preparation process, the controllability of the generation conditions of the pore diameter and the pore density of the surface of the microcapsule is realized, and finally the controllable release of the core material is realized.

The invention discloses a biological agent for preventing and treating panax notoginseng root rot, and relates to the technical field of biological prevention and treatment, the biological agent is composed of four layers of functional florae: an A layer of sentinel-decoding flora is used for identifying a pathogen quorum sensing signal and is used as an event trigger source, a B layer of metabolic countering flora is used for decoupling conversion of disease-promoting saponin and controllable release of a metabolic false substrate, and a C layer of functional florae is used for controlling root rot of panax notoginseng. The C-layer self-healing conductive biological membrane construction flora forms a biological membrane with conductivity and self-healing capability on the root surface, and the D-layer electrically-enabled flora constructs stable biological micro-current at the rhizosphere by using ferric oxide particles as external electron acceptors. The layer A triggers to cause controlled release of the layer B, a conversion product of the layer B provides a carbon source and a structural unit for the layer C, and a conductive network of the layer C and the layer D form an electronic path. The biological agent is used for early recognition and continuous inhibition of pathogens in panax notoginseng planting soil, can start defense response in the early stage of quorum sensing signal occurrence, and keeps action stability under complex environmental conditions.

The invention belongs to the technical field of medical materials, and particularly relates to magnetic control nano-enzyme hydrogel as well as a preparation method and application thereof. The FeSr MOF-coated PtNi is coated and modified by using an azide-modified macrophage membrane, the obtained PtNi / MIL-coated Mem has certain targeting property, a bacterial infection part can be recognized and enriched by using signal molecules and antibodies on the surface of the macrophage, the targeting property and the stability of nano-particle delivery are enhanced, the retention time of nano-enzyme after gel forming is longer, and the nano-enzyme is more stable and more stable. The treatment effect is better. The natural immune escape characteristic and biocompatibility of the macrophage membrane are utilized, and the application has remarkable advantages in the aspect of reducing immunological rejection and adverse reaction. In addition, the magnetic control nano-enzyme hydrogel can generate a large amount of ROS under the action of a magnetic field to destroy bacterial biofilms and kill bacteria, and controllable release of ROS is achieved. Meanwhile, Sr < 2 + > is released when the magnetic control nano-enzyme injectable hydrogel is degraded, angiogenesis is promoted, wound repair is promoted, and wound infection can be effectively treated.

The invention provides a fucoxanthin nano-emulsion preparation method, and relates to the technical field of biological medicine, fucoxanthin and medium chain triglyceride are used as raw materials to support an oil phase solvent, and the oil phase solvent is mixed with resistant dextrin, isomaltooligosacharide and fructo-oligosaccharide to prepare the fucoxanthin nano-emulsion. The oil-in-water fucoxanthin nano-emulsion with the particle size of 1-100nm is obtained by mixing water-phase solvents prepared from fucoxanthin, blood orange powder and the like, processing by a colloid mill and emulsifying and shearing by a vacuum tank, and the preparation increases the solubility of fucoxanthin, removes the unpleasant odor of fucoxanthin, reduces degradation of gastrointestinal tracts, improves the bioavailability, reduces the toxic and side effects of the fucoxanthin, improves the bioavailability of the fucoxanthin, and improves the bioavailability of the fucoxanthin. The controlled release and absorption of fucoxanthin are realized, and compared with traditional tablets and capsule products, the compliance of females, middle-aged people and old people who have difficulty in swallowing is greatly improved.

The invention provides a 3D printing anti-caries dental appliance and a method thereof, and belongs to the field of oral medical treatment, and the method specifically comprises the following steps: S1, combining fluoride ions with crown ether as a carrier through a chemical reaction in a polar aprotic solvent to form a stable subject-object compound; s2, the subject-object compound is purified, and the purified subject-object compound is verified; s3, the checked subject-object compound is mixed with a 3D printing base material, and a 3D printing raw material is obtained; s4, according to design parameters, the raw materials are subjected to 3D printing to manufacture the anti-caries dental appliance. By means of the treatment scheme, the anti-caries component is evenly dispersed in the 3D printing base material, and fluorine ions can be effectively and continuously released in the oral cavity environment for a long time.

The invention discloses a dihydromyricetin enhanced gutta-percha / polylactic acid composite active packaging film and a preparation method thereof. According to the film, gutta-percha and polylactic acid are used as base materials, raspberry tea dihydromyricetin is used as an active component, and synergistic improvement of mechanical properties and biological activity is achieved. The specific preparation method comprises the following steps: dissolving gutta-percha in a first organic solvent to prepare a solution A; polylactic acid and a plasticizer are dissolved in a second organic solvent to prepare a solution B; and mixing the solution A and the solution B, adding dihydromyricetin, carrying out a stirring reaction, and carrying out film casting. The obtained film is faint yellow and semitransparent, the thickness is 30-40 microns, the tensile strength is larger than or equal to 33 MPa, the elongation at break is larger than or equal to 280%, and the good water vapor and oxygen barrier property is achieved. Benefited from the addition of dihydromyricetin, the film has remarkable bacteriostatic activity on escherichia coli and staphylococcus aureus, the DPPH free radical scavenging rate can reach 92.6%, the comprehensive performance is remarkably superior to that of a gutta-percha / polylactic acid composite film, and the gutta-percha / polylactic acid composite film has important application potential in the field of active packaging of food and agricultural products.

The invention belongs to the technical field of synthesis and application of complexes, and provides a metal carbonyl Mn complex taking a 2-picolinic acid derivative as a ligand as well as a preparation method and application of the metal carbonyl Mn complex. The chemical formula of the complex is [Mn (CO) 3 (L) Br], L is 2-picolinic acid, 5-Cl-2-picolinic acid, 5-Br-2-pyridylaldehyde or 6-Br-2-picolinic acid methyl ester, and the complex with four different substituent groups has high water solubility and has an obvious effect on improving the water solubility of CORM. The four complexes can realize CO controllable release under different illumination wavelengths, and can be applied to preparation of donors capable of realizing CO controllable release in visible light or near-infrared light. The compound can be combined with human serum protein to prepare a serum protein complex, and can be applied to metabolism regulation and cell targeting carrying of the complex. The growth of human cervical cancer HeLa cells is obviously inhibited, and the compound can be applied to screening and preparation of lead compounds of anti-tumor drugs.

This invention belongs to the field of traditional Chinese medicine fermentation technology, specifically involving a high-enzyme-active Liu Shen Qu (a type of fermented medicinal herb) and its fermentation process. The process first processes red beans, bitter almonds, artemisia annua, cocklebur, and polygonum hydropiper into a medicinal porridge, which is then mixed with wheat flour and a specific fermenting agent to form a soft mass. Its innovation lies in the use of a Bacillus subtilis trehalose protective agent complex and Aspergillus oryzae chitosan microspheres. These two fermenting agents are prepared by spray drying encapsulation and ionogel methods, respectively, significantly improving the survival rate and stability of the fermenting microorganisms during processing and storage. The soft mass undergoes two stages of precisely controlled temperature and humidity fermentation, and finally, after shaping and segmented drying, the finished product is obtained. This process effectively solves the problems of low enzyme activity and poor stability in traditional Liu Shen Qu fermentation, resulting in a Liu Shen Qu product with high digestive enzyme activity and stable, uniform quality.

This invention relates to the field of polymer material additives, and discloses an environmentally friendly calcium-zinc composite PVC heat stabilizer and its preparation method. The heat stabilizer is a multi-level core-shell structure particle composed of three parts: (a) a functionalized hydrotalcite core intercalated with β-diketone and polyol; (b) a calcium / zinc metal soap inner shell chemically bonded to the core surface via a silane coupling agent; and (c) a lanthanum-organic complex outer shell coating the outermost layer containing unsaturated double bonds. The preparation method includes: preparing the functionalized core, grafting a silane coupling agent, in-situ co-precipitation to generate the inner shell, and solvent evaporation to coat the outer shell. This invention ensures the integrity of the composite particle structure and the synergistic effect of each component by constructing a stable chemical connection between the core and shell. Through intercalation and final chemical grafting, the migration and precipitation problems of the additives are fundamentally solved.

The application discloses a kind of artificial humic acid slow-release fertilizer based on lignocellulose fermentation residue and a preparation method thereof.The method uses lignocellulose fermentation residue as raw material, through alkali catalytic depolymerization and amino reaction, lignin is converted into artificial humic acid, and combines hydroxyapatite to load nutrients such as nitrogen, phosphorus and potassium, to construct a three-dimensional slow-release network structure with carboxymethyl cellulose-calcium chloride ion crosslinking system, and artificial humic acid slow-release fertilizer is prepared.The slow-release fertilizer of the application has excellent slow-release performance, and the nutrient elements can be released stably, which improves the utilization rate of fertilizer, reduces nutrient loss, has soil improvement and slow-release fertilizer efficiency, and is suitable for facility agriculture, ecological restoration and sustainable agricultural development.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

The invention relates to the technical field of biomedical materials, in particular to a nano assembly for releasing NO through red light triggering and a preparation method and application of the nano assembly. The nano assembly is prepared from an amphiphilic block polymer with a polyethylene glycol hydrophilic end and a hydrophobic segment containing NO donor molecules and photocatalyst molecules through a hydrophilic and hydrophobic self-assembly forming method. Photocatalyst molecules in the amphiphilic block polymer are excited under irradiation of red light, decomposition of NO donor molecules can be triggered through an electron transfer process, and space-time controllable adjustment of NO release is achieved. The nano assembly has the red light response characteristic, excellent biological safety and antibacterial property, and has a wide application prospect in the aspects of antibiosis, anti-inflammation and the like. In addition, the red light has the characteristics of large tissue penetration depth and low phototoxicity, so that the problem that the penetration depth of the traditional ultraviolet light or blue light response NO donor molecular monomer is limited is effectively solved.

The invention provides a functional material doped with silver modified calcium peroxide nanoparticles as well as a preparation method and application of the functional material, and belongs to the technical field of hydrogel material preparation and antibacterial materials. According to the functional material, oxidized dextran and carboxymethyl chitosan are used as a skeleton structure to prepare Schiff base hydrogel, and silver-modified calcium peroxide nanoparticles are doped in the Schiff base hydrogel; the silver-modified calcium peroxide nanoparticles are obtained by modifying the surface of calcium peroxide with silicon dioxide and then modifying silver nanoparticles. The functional material doped with the silver modified calcium peroxide nanoparticles has excellent antibacterial activity and long-acting antibacterial ability, has long-acting and excellent bactericidal activity on typical gram-positive bacteria and gram-negative bacteria, and has good antibacterial application in a microenvironment with bacterial infection.

The invention discloses an eye protection patch as well as a preparation method and application thereof, and belongs to the field of dressing and makeup type configuration products. The eye patch is mainly prepared from polyvinyl alcohol, polyethylene glycol, poly (N-isopropylacrylamide), N, N '-methylene bisacrylamide, lauryl sodium sulfate, an initiator combination, a plant extract, xanthophyll and hyaluronic acid according to a specific proportion and a specific preparation process, and the plant extract can be controlled to release at the body temperature.

The invention relates to the technical field of functional foods and health-care products, and discloses a weight-reducing beverage based on coffee and natural plant extracts and a preparation method of the weight-reducing beverage. The beverage consists of the following components: 2% of a coffee bean extract, 3% of a green tea extract, 0.1% of capsaicin, 2% of a Hoodia gardonii extract, 3% of a white kidney bean extract, 1.5% of a turmeric extract, 1% of L-theanine, 0.2% of a vitamin B group compound, 1% of a sweetening agent, 0.5% of a stabilizer and 85.7% of water. According to the weight-reducing beverage based on coffee and natural plant extracts and the preparation method thereof, organic raw materials from specific regions are selected, so that the guarantee of high quality and purity of components is realized, the concentration and stability of effective components in the beverage are improved, and the weight-reducing effect is enhanced; according to the preparation method, plant raw materials are subjected to pretreatment steps of cleaning, baking, freeze drying and the like, so that impurities and pollutants are removed, active ingredients are reserved to the greatest extent, the bioavailability of the active ingredients in a final product is enhanced, and the loss of the active ingredients in the processing process is reduced.

The application relates to a diaphragm and an electrochemical device and an electronic device comprising the same, and belongs to the technical field of electrochemical energy storage. The diaphragm provided by the application comprises a diaphragm base material and a solid-state ion source layer arranged on at least one side of the diaphragm base material, the solid-state ion source layer comprising lithium salt, a functional additive and an ion conductor composite, the ion conductor composite comprising a binder and an ion conductor; the lithium salt comprises at least one of lithium bisfluorosulfonylimide, lithium bis-trifluoromethanesulfonylimide, lithium difluoro(oxalato)borate, lithium tetrafluoroborate and lithium bis(oxalato)borate. The diaphragm provided by the application can be matched with a non-solute and low-viscosity electrolyte, the liquid injection time in preparation is reduced, the controllable release of lithium salt is realized, and the cycle stability and safety performance are improved.

The invention provides an Anti-PD-L1 and Anti-HER2 double-antibody guide nano-drug system as well as a preparation method and application thereof, and belongs to the technical field of composite material preparation and biological medicine. Perovskite quantum dots with a wide photoluminescence spectrum are combined to the surface of accurately designed and prepared Gd-MOF to obtain a nano composite material, and then the nano composite material is used as a carrier to be covalently coupled with Anti-PD-L1 and Anti-HER2 antibodies and loaded with an anti-cancer drug to obtain a double-antibody guided nano drug system. The double-antibody guided nano-drug system provides a multi-mode imaging strategy for tumor diagnosis, exerts the treatment effect of combining multiple treatment methods in tumor combined treatment, and realizes the synergistic effect of chemical treatment, immunotherapy and photodynamic therapy; the invention can be applied to the development and clinical practice of tumor diagnosis technology and tumor treatment drugs.