494results about How to "Achieve controlled release" patented technology

The invention relates to a stable controlled release particle pesticide-containing fertilizer. The pesticide-containing fertilizer has a core-shell structure, is granular and comprises a core which is composed of a fertilizer and a microcapsule pesticide or pesticide pulvis adsorbed by a porous material, and a shell which is used as a controlled release layer. The invention enables the pesticide and the fertilizer to stably exist and to be slowly released, frequency of pesticide application and fertilizer application in growth stages of crops to be reduced and field labor to be saved.

The invention relates to a preparation method of modified biologically-activated filter fillings, comprising the following steps of: (1) cleaning an inorganic carrier with the grain diameter of 3-8 millimetres, sequentially carrying out acid cleaning, alkaline cleaning and drying to obtain dry fillings; (2) adding the dry fillings to a metal salt solution to carry out soaking and ultraphonic, drying and sintering to obtain sintering charges; (3) naturally cooling and drying the sintering charges to obtain dry sintering charges; (4) adding the dry sintering charges to a polymeric hydrogel solution containing trace elements and nutrient salts, carrying out soaking and ultraphonic and reacting in a saturated boric acid solution or a 3% calcium chloride solution so as to obtain crosslinked fillings; and (5) drying and naturally cooling the crosslinked fillings so as to obtain the modified biologically-activated filter fillings. The invention has the advantages of simple process and easy implementation; and in addition, the obtained modified biologically-activated filter fillings can increase the activity and the number of biomembranes, shorten the membrane-forming periods of biological aerated filter fillings and enhance the sewage treatment efficiency and the stability of a biological aerated filter.

The invention relates to artificial valve prosthesis with a valve leaflet clamping device. The manual valve prosthesis comprises a bracket and an artificial valve, wherein the bracket comprises an auxiliary support clamping section and a valve sewing section; the artificial valve is fixedly connected to the valve sewing section; the auxiliary support clamping section is composed of a support bracket, a valve leaflet clamping device and an upper connection fixing section; the leaflet clamping device, the support bracket and the upper connection fixing section are integrally cut; a lower connection fixing section matched with the upper connection fixing section is arranged on the valve sewing section; the bracket is embedded and connected with the lower connection fixing section into a whole through the upper connection fixing section; one part of the valve leaflet clamping device is overlapped with the valve sewing section; the overlapped part is tightly attached to the outer surface of the valve sewing section in a natural state; a bump which protrudes outwards along the radial direction is arranged on a skeleton structure of the valve sewing section in the overlapped region; and a bending section which bends towards the axis direction of the bracket along the radial direction of the bracket is arranged on the valve leaflet clamping device or the support bracket or the upper connection fixing section.

The invention discloses a method for preparing high-temperature resistant essence microcapsules, which comprises the following steps: preparing aqueous solution of gelatin and aqueous solution of Arabic gum by gelatin and Arabic gum respectively, then adding oil-soluble essence into the aqueous solution of Arabic gum and performing homogenization and emulsification on the solution, and uniformly mixing the emulsified solution and the aqueous solution of gelatin to obtain emulsified liquid; adjusting the pH of the emulsified liquid to 4.15-4.17 by using edible acetic acid; dissolving a curing agent glutamine transaminase in water, and then mixing solution of the curing agent and the emulsified liquid to perform curing; filtering the cured emulsified liquid, discarding the supernate, and collecting the sediment; dissolving a wall material obtained by mixing Arabic gum, malt dextrin, glucose and isolated soy protein in the water, then adding the collected sediment into the solution of wall material to be uniformly mixed, and preparing the mixture into the high-temperature resistant essence microcapsules by adopting a spray drying method. The method prepares the oil-soluble essence into the microcapsules so as to keep the primary fragrance of the essence and ensure the using effect in high-temperature processing.

The invention discloses a soluble coaxial-cone multi-layer microneedle. The microneedle is in a cone shape; an internal structure of the microneedle comprises a cone-shaped or conical-cylinder-shaped center layer, and one or more outer layers wrapping the center layer; the center layer and the outer layers are prepared by active drugs and/or structural materials; and a mass ratio of the active drugs to the structural materials is (10:1)-(1:100). The multi-layer structure of the microneedle can be dissolved layer by layer and step by step during intracutaneous contact and body fluid contact, so that the drug release time of one or more drugs and a procedure of drug release dosage can be controlled, and the microneedle can be used for partial skin treatment or whole body administration.

The invention relates to a pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as a preparation method and an application thereof. A hydrophilic layer which at least contains PCB (Polycarboxylate Betaine) or PEG (Polyethylene Glycol) is positioned on the surface of the nanoparticle, a hydrophobic nuclei which at least contains a pH-sensitive polymer unit is positioned in the nanoparticle, and an S-S (Disulfide Bond) cross-linking layer which is formed through cross-linking reaction between PDS (Polymethacrylamide Ehtylpyridine Disulfide) units is positioned between the hydrophilic layer and the hydrophobic nuclei. A tumor targeted group can be modified on the hydrophilic layer positioned on the surface of the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, and the gathering of the nanoparticle on a tumor tissue and the endocytosis of the nanoparticle on the tumor cell are accelerated through the specific targeted effect of the nanoparticle on a tumor cell. The pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle disclosed by the invention has the advantages of good biocompatibility and low toxicity. According to the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, a cross-linked structure is dissociated under the action of glutathione inside the tumor cell, so that the release of a medicine is promoted. The preparation method disclosed by the invention is simple, convenient, good in stability and conveniently operated and popularized.

The invention relates to a photosensitive PRP (platelet-rich plasma) gel and a preparation method and application thereof. The preparation method comprises the following steps of mixing a biocompatible medium solution of a macromolecule modified by an o-nitrobenzyl photo response group and an extracted PRP according to a certain ratio, so as to form a gel precursor solution; then, radiating the gel precursor solution by light, and enabling the o-nitrobenzyl group in the macromolecule modified by the o-nitrobenzyl photo response group to generate photochemical reaction under the excitation action of a light source, so as to produce an aldehyde functional group; generating coupling reaction with amino distributed at the surface of the protein in the PRP to form an imine bond, so as to realize the preparation of the photosensitive PRP gel. Compared with the prior art, the photosensitive PRP gel prepared by the method has the advantages that the internal cell factors can be slowly released, and the tight and seamless bonding between the PRP gel and wounds is realized.

A preparation method of vitamin A and vitamin E nano-sphere/microsphere double-embedding system belongs to the technical field of biological active substance control release microencapsulation. In the present invention, food grade vitamin A is nano-sphere core material and monoglyceride or beeswax is nano-sphere wall material to be made into nano-sphere suspension which is used as microsphere core material together with the vitamin E; ocentyl succinate esterified starch containing tween-80 is used as microsphere wall material; the nano-sphere/microsphere double-embedding system is manufactured by a thermal homogenization-spray drying method. The encapsulation rate towards the vitamin A of vitamin A nano-sphere manufactured by the present invention can reach to 82 percent to 94 percent, and the particle size of the nano-sphere is 200nm to 370nm. The encapsulation rate towards the vitamin A of the double-embedding system is 86 percent to 91 percent and the encapsulation rate towards the vitamin E is 89 percent to 93 percent. The double-embedding system can embed the vitamin A and the vitamin E synchronously and has the effect of releasing step be step, so as to avoid the mutual interference of active components, improve the biological utilization rate and can be added into various foods as vitamin intensifier and extender.

The present invention provides a method for preparing hollow polymer nanofibers by using a coaxial electrospinning technology. The method comprises the following steps: 1) adopting glycerol or a mixture of glycerol and water as an inner phase electrospinning liquid of coaxial electrospinning; 2) adopting a polymer solution as an outer phase electrospinning liquid; 3) respectively connecting the inner phase electrospinning liquid and the outer phase electrospinning liquid to a liquid inlet of a coaxial electrospinning nozzle; 4) controlling flow rates of the inner phase electrospinning liquid and the outer phase electrospinning liquid, and carrying out coaxial electrospinning to obtain the hollow polymer nanofibers on a receiving plate. Compared with the existing preparation technology, the preparation method of the present invention has the following advantages that: the liquid glycerol is adopted as the inner phase electrospinning liquid so as to prepare the hollow nanofibers through a one-step method, such that the preparation process is simple; the glycerol provides good biocompatibility for most of bioactive macromolecules, and bioactive substances such as biological enzymes and the like are added to the inner phase electrospinning liquid, such that efficient in-situ loading of the bioactive substances in the hollow nanofiber cavity can be achieved.

The invention relates to a thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane and a preparation method thereof, relating to a medicine-loading electro-spun fibrous membrane and a preparation method thereof and aiming to solve problems of poor mechanical property of existing poly N-isopropylacrylamide medicine-loading electro-spun fibrous membrane and no temperature sensitivity of a polyurethane medicine-loading electro-spun fibrous membrane. The thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane is prepared by poly N-isopropylacrylamide, polyurethane, N,N-dimethylformamide and a medicine; the preparation method comprises the following steps: 1, preparing static spinning solution; 2, dissolving the medicine so as to obtain the static spinning solution containing the medicine; 3, carrying out electrospinning; and 4, carrying out dry treatment to obtain the thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane. According to the invention, the preparation method is mainly used for preparing the thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane.

The invention provides an anastomat for gastrointestinal tract anastomosis surgery and a production method thereof. The anastomat comprises an anastomosis nail and a base and is divided into two types, namely a combined type and an independent type. The anastomat is composed of degradable materials and medical barium sulfate and can be finally disintegrated to be powder to be removed from the body after being used up. An envelope is formed on the outer surface of the anastomat through polyacrylic resin and contains medicines such as sulfonamides and quinolones antisepsis and anti-inflammation medicines and adrenobazonum, dicynone and other hemostasis medicines, and the envelope can selectively perform medicine slow release and controlled release according to different pH physiological environments of gastrointestinal tracts.

The invention relates to a Prussian blue-based intelligent pH-triggered MRI drug release-monitoring synergetic nanometer diagnosis and treatment agent and a preparation method thereof. The nanometer diagnosis and treatment agent comprises hollow Prussian blue nanometer particles with mesopores. The surfaces of the hollow Prussian blue nanometer particles with mesopores are coated with KxMny[Fe(CN)6]z, wherein x is greater than or equal to 0.05 and less than or equal to 0.3, y is greater than or equal to 0.5 and less than or equal to 0.98 and z is equal to 1. The nanometer diagnosis and treatment agent comprises hollow mesoporous nanometer particles with core-shell structures. The HMPB-Mn nanometer diagnosis and treatment agent is used for tumor part pH-sensitive MRI and pH-sensitive drug release control in chemotherapy. Through combination with thermotherapy, MRI-guided thermotherapy-chemotherapy combined treatment on tumors is realized.

The invention belongs to an inorganic mesoporous material area, in particular to a preparation method of a controllable silica hollow sphere material in a certain diameter range. The anionic surfactant sodium dodecyl sulfonate (SDS) controls the synthesis of spherical wall, which is provided with mesoporous channels and narrow distribution of diameter. The invention uses block copolymer and sodium dodecyl sulfonate as mixing template; with the addition of silicon source, the sol is formed after mixing; under the acid condition, through the agitating and aging treatment, after hydrothermal process, filtering and drying, the template is calcined to obtain silica hollow sphere with the mesoporous channel. Through changing the content of SDS, the synthesis of different size of silica hollow spheres with the mesoporous channel can be controlled. The invention has a simple process and a low cost; the mesoporous shell thickness and the pore diameter of the prepared silica hollow sphere with the mesoporous channel can be controlled in a large range; the invention is beneficial to the internal and external transmission of guest molecules; the invention also improves the reserves of guest molecules, which realizes the controlled release effectively.

An injection of aquatic gel sensitive to pH value and glucose for controlling the release of the medicine wrapped by it is prepared through preparing the quaternary ammonium salt of chitosan, dissolving it along with polyethanediol in acid solution, adding the solution of glycerin phosphate, stirring, and gelatinizing.

The invention discloses an anti-bacterial composition as well as a controlled-release anti-bacterial film and an implant material prepared from the anti-bacterial composition. The anti-bacterial composition comprises first-class macromolecule selected from polylactic acid, polycaprolactone, polylactic acid-hydroxy acetic acid copolymer and polycaprolactone-hydroxy acetic acid copolymer, second-class macromolecule selected from polylactic acid-polyethyleneglycol block copolymer, polycaprolactone-polyethyleneglycol block copolymer, polyethylene oxide, polyvinyl alcohol, gelatin and hyaluronic acid, and an antimicrobial agent. The controlled-release anti-bacterial film prepared from the anti-bacterial composition which is provided by the invention can be adopted to achieve the purpose of releasing the antimicrobial agent in a controllable manner.

The invention relates to a biodegradable microorganism sustained-release agent. The biodegradable microorganism sustained-release agent is prepared from microorganism bacterium powder, a carbon-source sustained-release body and a hydrogel bacterium agent carrier, wherein the microorganism bacterium powder and the carbon-source sustained-release body are suspended in the hydrogel bacterium agent carrier; the mass ratio of the carbon-source sustained-release body to the hydrogel bacterium agent carrier is 1 to (1 to 10000); the invention further relates to a preparation method and application of the microorganism sustained-release agent. The microorganism sustained-release agent provided by the invention has a remarkable sustained-release effect, the embedding rate of the microorganism bacterium powder is high and the sustained-release effect of the microorganism bacterium powder is remarkable; furthermore, the preparation method is simple and secondary pollution is effectively avoided; controllable release of a carbon source can be realized; the biodegradable microorganism sustained-release agent is applied to sewage management and waste of the carbon source, caused by flowing of a water body, can be effectively avoided through sustained-release of the carbon source, so that the utilization efficiency of microorganisms on the carbon source is improved and the nitrogen removal efficiency is improved; the ammonia-nitrogen reducing rate can reach 80 percent or more and the reducing rate of total nitrogen can reach 20 percent; a relatively good quality effect is realized.

The invention discloses an antibacterial packaging film and a preparation method thereof. The antibacterial packaging film comprises chitosan as a main raw material and further comprises plant essential oil which is used as an antibacterial agent. By using a plant essential oil microcapsule formed by beta-cyclodextrin and plant essential oil as the antibacterial agent, the antibacterial packaging film not only can be used for improving the stability of essential oil, but also can be used for controlled release of the essential oil. In addition, the raw material chitosan is an environment-friendly macromolecular compound, so that the antibacterial packaging film has a good film-forming property and is excellent in antibacterial property.

The invention relates to a control technology specially used for preventing and controlling important forest pest bursaphelenchus xylophilus (monochamus alternatus), namely a microcapsule powder agent or a microcapsule suspending agent prepared by a highly-efficient, harmfulless and less-persistent neonicotinoid insecticide thiacloprid sustained-release preparation and assisted by a high-adhesionadhesive is adopted for prevention and control. The technology adopts an innocuous and degradable carrier as shell materials, is safe to environment, has excellent durable effect and solves the greatproblems of bursaphelenchus xylophilus prevention and control and chemical pesticide pollution.

The invention discloses a multi-stimuli responsive shell crosslinked polymeric micelle and a preparation method thereof. The polymeric micelle is prepared by: carrying out ATRP and click chemistry reaction to synthesize an amphiphilic diblock polymer with polydimethylaminoethyl methacrylate (PDMAEMA) as the hydrophilic chain and polymethacrylate ferrocenyl formyloxy ethyl ester (PMAFFEE) as the hydrophobic chain, subjecting the polymer to self-assembly in water to form core-shell micelles with uniform size, and then carrying out cross-linking reaction on the micelles and N, N'-di(bromoacetyl)cystamine. The core-shell crosslinked polymeric micelle provided by the invention is responsive to temperature, pH, light, oxidation and reduction stimuli, drugs can be released under single triggering of different stimuli in a controlled release process, and also can achieve controlled release through joint triggering of multiple stimuli. Therefore, the multi-stimuli responsive shell crosslinked polymeric micelle has broad application prospect in controlled release of anti-cancer drugs and other fields.

The invention provides a targeted tumor active oxygen responsive medicine carrying nano-micelle, a preparation method and application of the medicine carrying nano-micelle, a medicine carrying nano-micelle intermediate RGD-PEG-thioketal-anthracene ring chemotherapy medicine conjugate and a preparation method of the conjugate. The nano-micelle, the conjugate as well as the preparation methods and application thereof have the beneficial effects that laser irradiates for activating porphyrin type photosensitive molecules; a large number of active oxygen radicals are triggered to be generated; further, thioketal in the medicine carrying nano-micelle system is induced to fracture; the controlled release of the anthracene ring chemotherapy medicine in the tumor position is realized; the medicinecurative effect is enhanced; the toxic and side effects of the medicine are reduced; PDT is combined with chemotherapy; the prominent synergistic interaction effect is achieved; the alone antitumor effect of a photodynamic therapy is improved; the toxic and side effects of the anthracene ring chemotherapy medicine on important visceral organs are also reduced.

The invention relates to a method for preparing double-wall fresh ginger volatile oil microcapsules.The method includes the steps that fresh ginger volatile oil is dispersed in an inner layer wall material and homogenized at normal temperature and high pressure, and a primary suspension is prepared; secondly, the primary suspension is dispersed in an outer layer wall material, emulsifier is added, the primary suspension is homogenized at normal temperature and high pressure, and a secondary suspension is obtained; thirdly, the secondary suspension is dried, and the double-wall fresh ginger volatile oil microcapsules are obtained.The embedding rate of the prepared fresh ginger microcapsules is 81-98%, in the preparation process, the technology that fresh ginger volatile oil is supercritically extracted and normal-temperature double-layer embedding, high-pressure homogenization and freezing or spray drying are conducted is adopted, so that the product embedding rate is high, the embedding effect is good, flowability is good, stability of effective components of the fresh ginger volatile oil can be improved, bioavailability is high, and the method is used in the food and health-care product field.

The invention discloses a reverse osmosis membrane, a preparation method and application thereof. The reverse osmosis membrane comprises a porous filter membrane supporting layer, a carbon nanotube membrane middle layer and a polyamide membrane selection layer which are arranged in sequence. According to the invention, the reverse osmosis membrane is a stable composite membrane integrating a porous filter membrane, a carbon nano tube membrane and a polyamide membrane, wherein the porous filter membrane serves as the substrate loaded by the carbon nano tube membrane and provides good mechanicalstrength, the carbon nano tube membrane has uniformly distributed nano-sized apertures and high porosity, and is used as a support for an interfacial polymerization reaction so as to achieve uniformdistribution of a monomer solution and controllable release of a monomer to prepare an ultrathin and high-quality polyamide membrane, and the polyamide membrane as a performance determination layer has the characteristic of ultra-thinness, and makes the novel reverse osmosis membrane have the flux far higher than that of the traditional reverse osmosis membrane while retaining the high rejection rate. According to the reverse osmosis membrane disclosed by the invention, the carbon nano tube membrane middle layer with uniformly distributed nano-sized apertures and high porosity is introduced for the first time, so that the performance is substantially improved.

The invention discloses a method of preparing a controlled-release antibacterial film and an implant material by using an antibacterial composition. The method comprises the following steps of: injecting the antibacterial composition into an injector and installing a stainless steel needle head; coating a to-be-coated implant material by adopting a high-voltage power supply with voltage of 10 KV-30 KV at liquor flow velocity of 1 mL/h-5 mL/h and receiving distance of 5 cm-25 cm; finally, drying the coated implant material in vacuum under the room temperature for 24 hours-48 hours to obtain the controlled-release antibacterial film coated on the implant material, wherein the antibacterial composition comprises: first-class macromolecules selected from polylactic acid, polycaprolactone, polylactic acid-hydroxyacetic acid copolymer and polycaprolactone-hydroxyacetic acid copolymer, second-class macromolecules selected from polylactic acid-polyethylene glycol segmented copolymer, polycaprolactone-polyethylene glycol segmented copolymer, polyethylene oxide, polyvinyl alcohol, gelatin and hyaluronic acid, and an antibacterial agent. The controlled-release antibacterial film prepared by the method disclosed by the invention can realize controlled release of the antibacterial agent.