48results about How to "Achieve controlled release" patented technology

The invention discloses injectable hydrogel for eye drug sustained release and a preparation method and application thereof.The method comprises the steps that a NaIO4 solution is dropwise added into a hyaluronic acid solution, after the reaction is conducted in a dark place at the room temperature, ethylene glycol is added for continuous reaction, and formylated hyaluronic acid is prepared; the preparation method comprises the following steps: adding adipic dihydrazide into a carboxymethyl cellulose solution, uniformly stirring at room temperature, adding 1-hydroxybenzotriazole and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and stirring to react, so as to prepare aminated carboxymethyl cellulose; and mixing the PBS solution of aminated carboxymethyl cellulose with the PBS solution of formylated hyaluronic acid, uniformly stirring, adding a to-be-carried drug and a FeCl3 solution, and carrying out a reaction to prepare the injectable hydrogel for sustained release of the eye drug. The hydrogel is convenient to use and high in gelation rate, effectively realizes controllable release of drugs, and has a wide application prospect in the field of biological medicines.

The invention relates to the field of hydrogel materials, in particular to a hydrogel dressing as well as a preparation method and application thereof. The deferoxamine mesylate is loaded on the gelatin microsphere material constructed by the gelatin and the genipin, so that the loading dispersion of the deferoxamine mesylate can be benefited, and the added gelatin can be in contact with matrix proteinase-9 in a diabetic foot ulcer microenvironment for degradation so as to induce the release of the deferoxamine mesylate. A first cross-linked network is formed by the 3-carboxyphenylboronic acid modified chitosan and the oxidized hyaluronic acid, and the gelatin microsphere material loaded with the deferoxamine mesylate and the epigallocatechin gallate are coated with the first cross-linked network. The hydrogel dressing realizes controllable release of the deferoxamine mesylate and the epigallocatechin gallate, so that the technical problem of uncontrollable release of the deferoxamine mesylate is solved.

The invention discloses injectable and degradable composite drug-loading hydrogel as well as a preparation method and application thereof. The injectable and degradable composite drug-loading hydrogel comprises sodium alginate hydrogel, piezoelectric nanofibers and triamcinolone acetonide and / or ropivacaine, wherein the piezoelectric nanofibers and the triamcinolone acetonide and / or the ropivacaine are loaded on the sodium alginate hydrogel; the piezoelectric nanofibers are poly-L-lactic acid nanofibers. Through the synergistic effect of controllable release of the medicine and piezoelectric stimulation, the dual effects of continuous analgesia and neural restoration are achieved in the PHN treatment process, more effective treatment selection is provided for a PHN patient, complications caused by a traditional implantable electrode can be avoided, a more minimally invasive, convenient and safe treatment mode can be provided for the patient, and the treatment effect is good. And a theoretical basis is provided for future clinical practice.

The invention relates to the technical field of antibacterial materials, and provides a light-enzyme-heat synergistic antibacterial nano composite material and a preparation method thereof.The preparation method comprises the steps that 1, a copper-based chalcogenide with a plasma resonance effect serves as a structural template, a transition metal oxide intermediate layer and a bismuth oxyhalide epitaxial layer are sequentially constructed on the surface of the copper-based chalcogenide with the plasma resonance effect through a step-by-step continuous solvothermal method, and the copper-based chalcogenide with the plasma resonance effect serves as the structural template; forming a core-shell heterojunction with Z-type energy band matching; (2) pre-assembling a natural enzyme and a monatomic nano-enzyme in a buffer system to form a composite catalytic unit with an electron transfer channel; and (3) by taking the core-shell heterojunction as a polymerization core, under the precise temperature control condition of 0-10 DEG C, initiating active free radical polymerization through an interface, constructing a thermal response polymer shell layer on the surface of the heterojunction, and encapsulating the composite catalytic unit in a functional microdomain of a polymer network in situ. The anti-bacterial fabric can achieve a better synergistic anti-bacterial effect.

The invention discloses a biological agent for preventing and treating panax notoginseng root rot, and relates to the technical field of biological prevention and treatment, the biological agent is composed of four layers of functional florae: an A layer of sentinel-decoding flora is used for identifying a pathogen quorum sensing signal and is used as an event trigger source, a B layer of metabolic countering flora is used for decoupling conversion of disease-promoting saponin and controllable release of a metabolic false substrate, and a C layer of functional florae is used for controlling root rot of panax notoginseng. The C-layer self-healing conductive biological membrane construction flora forms a biological membrane with conductivity and self-healing capability on the root surface, and the D-layer electrically-enabled flora constructs stable biological micro-current at the rhizosphere by using ferric oxide particles as external electron acceptors. The layer A triggers to cause controlled release of the layer B, a conversion product of the layer B provides a carbon source and a structural unit for the layer C, and a conductive network of the layer C and the layer D form an electronic path. The biological agent is used for early recognition and continuous inhibition of pathogens in panax notoginseng planting soil, can start defense response in the early stage of quorum sensing signal occurrence, and keeps action stability under complex environmental conditions.

The invention provides a fucoxanthin nano-emulsion preparation method, and relates to the technical field of biological medicine, fucoxanthin and medium chain triglyceride are used as raw materials to support an oil phase solvent, and the oil phase solvent is mixed with resistant dextrin, isomaltooligosacharide and fructo-oligosaccharide to prepare the fucoxanthin nano-emulsion. The oil-in-water fucoxanthin nano-emulsion with the particle size of 1-100nm is obtained by mixing water-phase solvents prepared from fucoxanthin, blood orange powder and the like, processing by a colloid mill and emulsifying and shearing by a vacuum tank, and the preparation increases the solubility of fucoxanthin, removes the unpleasant odor of fucoxanthin, reduces degradation of gastrointestinal tracts, improves the bioavailability, reduces the toxic and side effects of the fucoxanthin, improves the bioavailability of the fucoxanthin, and improves the bioavailability of the fucoxanthin. The controlled release and absorption of fucoxanthin are realized, and compared with traditional tablets and capsule products, the compliance of females, middle-aged people and old people who have difficulty in swallowing is greatly improved.

The invention discloses a dihydromyricetin enhanced gutta-percha / polylactic acid composite active packaging film and a preparation method thereof. According to the film, gutta-percha and polylactic acid are used as base materials, raspberry tea dihydromyricetin is used as an active component, and synergistic improvement of mechanical properties and biological activity is achieved. The specific preparation method comprises the following steps: dissolving gutta-percha in a first organic solvent to prepare a solution A; polylactic acid and a plasticizer are dissolved in a second organic solvent to prepare a solution B; and mixing the solution A and the solution B, adding dihydromyricetin, carrying out a stirring reaction, and carrying out film casting. The obtained film is faint yellow and semitransparent, the thickness is 30-40 microns, the tensile strength is larger than or equal to 33 MPa, the elongation at break is larger than or equal to 280%, and the good water vapor and oxygen barrier property is achieved. Benefited from the addition of dihydromyricetin, the film has remarkable bacteriostatic activity on escherichia coli and staphylococcus aureus, the DPPH free radical scavenging rate can reach 92.6%, the comprehensive performance is remarkably superior to that of a gutta-percha / polylactic acid composite film, and the gutta-percha / polylactic acid composite film has important application potential in the field of active packaging of food and agricultural products.

The invention belongs to the technical field of synthesis and application of complexes, and provides a metal carbonyl Mn complex taking a 2-picolinic acid derivative as a ligand as well as a preparation method and application of the metal carbonyl Mn complex. The chemical formula of the complex is [Mn (CO) 3 (L) Br], L is 2-picolinic acid, 5-Cl-2-picolinic acid, 5-Br-2-pyridylaldehyde or 6-Br-2-picolinic acid methyl ester, and the complex with four different substituent groups has high water solubility and has an obvious effect on improving the water solubility of CORM. The four complexes can realize CO controllable release under different illumination wavelengths, and can be applied to preparation of donors capable of realizing CO controllable release in visible light or near-infrared light. The compound can be combined with human serum protein to prepare a serum protein complex, and can be applied to metabolism regulation and cell targeting carrying of the complex. The growth of human cervical cancer HeLa cells is obviously inhibited, and the compound can be applied to screening and preparation of lead compounds of anti-tumor drugs.

This invention belongs to the field of traditional Chinese medicine fermentation technology, specifically involving a high-enzyme-active Liu Shen Qu (a type of fermented medicinal herb) and its fermentation process. The process first processes red beans, bitter almonds, artemisia annua, cocklebur, and polygonum hydropiper into a medicinal porridge, which is then mixed with wheat flour and a specific fermenting agent to form a soft mass. Its innovation lies in the use of a Bacillus subtilis trehalose protective agent complex and Aspergillus oryzae chitosan microspheres. These two fermenting agents are prepared by spray drying encapsulation and ionogel methods, respectively, significantly improving the survival rate and stability of the fermenting microorganisms during processing and storage. The soft mass undergoes two stages of precisely controlled temperature and humidity fermentation, and finally, after shaping and segmented drying, the finished product is obtained. This process effectively solves the problems of low enzyme activity and poor stability in traditional Liu Shen Qu fermentation, resulting in a Liu Shen Qu product with high digestive enzyme activity and stable, uniform quality.

This invention relates to the field of polymer material additives, and discloses an environmentally friendly calcium-zinc composite PVC heat stabilizer and its preparation method. The heat stabilizer is a multi-level core-shell structure particle composed of three parts: (a) a functionalized hydrotalcite core intercalated with β-diketone and polyol; (b) a calcium / zinc metal soap inner shell chemically bonded to the core surface via a silane coupling agent; and (c) a lanthanum-organic complex outer shell coating the outermost layer containing unsaturated double bonds. The preparation method includes: preparing the functionalized core, grafting a silane coupling agent, in-situ co-precipitation to generate the inner shell, and solvent evaporation to coat the outer shell. This invention ensures the integrity of the composite particle structure and the synergistic effect of each component by constructing a stable chemical connection between the core and shell. Through intercalation and final chemical grafting, the migration and precipitation problems of the additives are fundamentally solved.

The application discloses a kind of artificial humic acid slow-release fertilizer based on lignocellulose fermentation residue and a preparation method thereof.The method uses lignocellulose fermentation residue as raw material, through alkali catalytic depolymerization and amino reaction, lignin is converted into artificial humic acid, and combines hydroxyapatite to load nutrients such as nitrogen, phosphorus and potassium, to construct a three-dimensional slow-release network structure with carboxymethyl cellulose-calcium chloride ion crosslinking system, and artificial humic acid slow-release fertilizer is prepared.The slow-release fertilizer of the application has excellent slow-release performance, and the nutrient elements can be released stably, which improves the utilization rate of fertilizer, reduces nutrient loss, has soil improvement and slow-release fertilizer efficiency, and is suitable for facility agriculture, ecological restoration and sustainable agricultural development.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

The invention relates to the technical field of biomedical materials, in particular to a nano assembly for releasing NO through red light triggering and a preparation method and application of the nano assembly. The nano assembly is prepared from an amphiphilic block polymer with a polyethylene glycol hydrophilic end and a hydrophobic segment containing NO donor molecules and photocatalyst molecules through a hydrophilic and hydrophobic self-assembly forming method. Photocatalyst molecules in the amphiphilic block polymer are excited under irradiation of red light, decomposition of NO donor molecules can be triggered through an electron transfer process, and space-time controllable adjustment of NO release is achieved. The nano assembly has the red light response characteristic, excellent biological safety and antibacterial property, and has a wide application prospect in the aspects of antibiosis, anti-inflammation and the like. In addition, the red light has the characteristics of large tissue penetration depth and low phototoxicity, so that the problem that the penetration depth of the traditional ultraviolet light or blue light response NO donor molecular monomer is limited is effectively solved.

The invention provides a functional material doped with silver modified calcium peroxide nanoparticles as well as a preparation method and application of the functional material, and belongs to the technical field of hydrogel material preparation and antibacterial materials. According to the functional material, oxidized dextran and carboxymethyl chitosan are used as a skeleton structure to prepare Schiff base hydrogel, and silver-modified calcium peroxide nanoparticles are doped in the Schiff base hydrogel; the silver-modified calcium peroxide nanoparticles are obtained by modifying the surface of calcium peroxide with silicon dioxide and then modifying silver nanoparticles. The functional material doped with the silver modified calcium peroxide nanoparticles has excellent antibacterial activity and long-acting antibacterial ability, has long-acting and excellent bactericidal activity on typical gram-positive bacteria and gram-negative bacteria, and has good antibacterial application in a microenvironment with bacterial infection.

The invention relates to the technical field of functional foods and health-care products, and discloses a weight-reducing beverage based on coffee and natural plant extracts and a preparation method of the weight-reducing beverage. The beverage consists of the following components: 2% of a coffee bean extract, 3% of a green tea extract, 0.1% of capsaicin, 2% of a Hoodia gardonii extract, 3% of a white kidney bean extract, 1.5% of a turmeric extract, 1% of L-theanine, 0.2% of a vitamin B group compound, 1% of a sweetening agent, 0.5% of a stabilizer and 85.7% of water. According to the weight-reducing beverage based on coffee and natural plant extracts and the preparation method thereof, organic raw materials from specific regions are selected, so that the guarantee of high quality and purity of components is realized, the concentration and stability of effective components in the beverage are improved, and the weight-reducing effect is enhanced; according to the preparation method, plant raw materials are subjected to pretreatment steps of cleaning, baking, freeze drying and the like, so that impurities and pollutants are removed, active ingredients are reserved to the greatest extent, the bioavailability of the active ingredients in a final product is enhanced, and the loss of the active ingredients in the processing process is reduced.

The application relates to a diaphragm and an electrochemical device and an electronic device comprising the same, and belongs to the technical field of electrochemical energy storage. The diaphragm provided by the application comprises a diaphragm base material and a solid-state ion source layer arranged on at least one side of the diaphragm base material, the solid-state ion source layer comprising lithium salt, a functional additive and an ion conductor composite, the ion conductor composite comprising a binder and an ion conductor; the lithium salt comprises at least one of lithium bisfluorosulfonylimide, lithium bis-trifluoromethanesulfonylimide, lithium difluoro(oxalato)borate, lithium tetrafluoroborate and lithium bis(oxalato)borate. The diaphragm provided by the application can be matched with a non-solute and low-viscosity electrolyte, the liquid injection time in preparation is reduced, the controllable release of lithium salt is realized, and the cycle stability and safety performance are improved.

The application discloses a preparation method of a multifunctional nano drug of Fe-based MOF loaded CM-272, and relates to a preparation method of an anti-cancer nano drug.The application aims at solving the problem that the CM-272 action is limited due to the internal hypoxic environment of a tumor.Method: I, preparing a Fe-based metal organic framework;II, preparing a MIL-53@CM-272 nano drug.The application is used for the preparation of the multifunctional nano drug of the Fe-based MOF loaded CM-272.

The application discloses a controllable cold energy releaser and a cold storage system, and belongs to the technical field of cold storage energy saving. The controllable cold energy releaser comprises a refrigeration mechanism, a container, a cold storage medium, air ducts and a cold energy release control mechanism. The container is internally provided with the cold storage medium. The container is open at both ends and is integrally provided with heat preservation blocks at the openings. The air ducts are arrayed in the container. The air ducts are penetrated through the heat preservation blocks on both sides and are connected with the cold energy release control mechanism. The refrigeration mechanism is connected with the container and is used for refrigerating the cold storage medium. The outer wall of the container is provided with a heat preservation material layer. The heat preservation material layer is used for blocking the cold energy exchange between the cold storage medium and the outside. The controllable cold energy releaser can realize the controllable release of the cold energy of the cold storage medium, so that the energy saving and consumption reducing effect is further improved, and the automatic management level is improved.

The present invention relates to the technical field of polymer drugs, and in particular, to polymer prodrug compounds and preparation methods thereof, and polymer prodrug micelles and preparation methods thereof. The structural formula of the polymer prodrug compound is as follows: The polymer prodrug compound achieves effective tumor targeting, prolongs the circulation time, increases the accumulation of drugs in tumor cells, achieves precise targeting of drugs to tumor cells, and increases the controllable release of drugs in tumor tissues, avoiding the problem that polymer drugs formed by physical encapsulation are easily leaked during the circulation process in the organism.

This research relates to the biomedical field and describes a thermosensitive hydrogel loaded with ginger extracellular vesicles and tannic acid, its preparation method, and its application in the preparation of anti-infective drugs. The process includes extracting ginger-derived extracellular vesicles; loading tannic acid onto these vesicles to obtain TA@GDEVs; preparing SP hydrogels; and slowly adding TA@GDEVs to the SP hydrogel to form a GTSP hydrogel system. GDEVs exhibit anti-inflammatory and pro-repair activities; TA provides broad-spectrum antibacterial, anti-inflammatory, and antioxidant functions; the SP hydrogel endows the thermosensitive hydrogel composite system with injectable and in-situ gelation properties; the SP hydrogel not only provides in-situ gelation and a protective barrier for GDEVs and TA but also enables controlled release of the loaded material; through synergistic effects, the three components enable the thermosensitive hydrogel composite system to possess responsiveness to the infection microenvironment, enhanced antibacterial efficacy, immune remodeling, and tissue repair functions, demonstrating its potential as a multifunctional anti-infective wound repair material.

This invention belongs to the field of biomedical technology, specifically disclosing an injectable embolic agent, its preparation method, and its application. The embolic agent is a hydrocolloid system containing core-shell structured nanoparticles: the core contains Cu... 2+ Salt and ATOX1 inhibitors, where ATOX1 inhibitors can inhibit copper ion efflux and promote intracellular copper accumulation, and interact with Cu 2+ It synergistically induces copper death in tumor cells; the shell is a thermosensitive block copolymer hydrogel that can interact with Cu. 2+ Coordination bonds are formed, enhancing the stability of nanoparticles, while a sol-gel transition occurs at physiological temperatures, enabling precise vascular embolization; the overall core-shell structure allows for the formation of Cu... 2+ The sustained-release effect of ATOX1 inhibitors was observed. In the VX2 rabbit hepatocellular carcinoma model, this embolization agent significantly improved tumor necrosis rate and reduced metastasis rate compared to traditional iodized oil embolization; it also downregulated hypoxia- and angiogenesis-related factors such as HIF-1α, VEGF, and CD31, inhibited MMP9-mediated tumor invasion and metastasis, and promoted CD8+. + T-cell infiltration effectively improves the tumor immunosuppressive microenvironment after transarterial chemoembolization.

The invention discloses a photoelectric microneedle system with bionic electrical stimulation and drug controlled release functions, comprising: a silicon film which is a silicon film array of two different doping types; the hydrogel microneedle is arranged on the surface of the silicon film, and the hydrogel microneedle contains medicine. By arranging semiconductor films with different polarities in an array mode, a photo-generated electric field with the adjustable direction can be generated under illumination, the direction of the photo-generated electric field is kept consistent with an endogenous electric field formed after tissue damage, and therefore wireless, accurate and controllable bionic electrical stimulation is achieved. Different doping types of semiconductor films generate different-direction electric fields under illumination, and directional migration and on-demand release of drug molecules with different charge properties can be realized. The photogenerated electric field not only can simulate and enhance endogenous electric signals after skin injury and regulate and control cell migration, proliferation and reconstruction processes, but also can synchronously drive drugs to be accurately released from the microneedle hydrogel.

This invention discloses a near-infrared light-responsive thermo-electrically coupled titanium-based implant, its preparation method, and its application, belonging to the field of biomedical materials technology. The near-infrared light-responsive thermo-electrically coupled titanium-based implant provided by this invention comprises a porous titanium substrate and a composite hydrogel coating; the surface of the porous titanium substrate is sequentially disposed from the inside out with TiO2 / SrTiO3 heterojunctions, upconversion nanoparticles, and barium titanate nanoparticles; the upconversion nanoparticles are Yb. 3+ and Er 3+ Co-doped NaYF4 upconversion nanoparticles; a composite hydrogel coating is deposited on the surface of barium titanate nanoparticles, the composite hydrogel coating comprising MXene, pharmaceutically active ingredients, and a hydrogel carrier. This invention achieves synergistic coupling of photothermal and photoelectric-pyroelectric effects under near-infrared light irradiation by constructing a multi-layered synergistic structure on a porous titanium substrate, thereby synergistically realizing multiple functions such as promoting bone growth, antibacterial activity, and antitumor activity.

The utility model relates to a firework support and fireworks, and the firework support comprises a support main body and a plurality of side baffles, the multiple side baffles are sequentially and adjacently arranged in the circumferential direction of the support body. The side baffle is provided with at least one accessory mounting structure; the bracket main body comprises a first connecting seat and a second connecting seat; the second connecting seat is connected with the first connecting seat and is positioned right above the first connecting seat; the bottom end of the side baffle is movably connected with the side edge of the first connecting base. A pop-up structure is arranged on the side edge of the second connecting seat, and when the pop-up structure is in a compressed state, the top end of the side baffle abuts against the side edge of the second connecting seat; when the pop-up structure is in an extended state, the top end of the side baffle is separated from the side edge of the second connecting base under the action of the elastic force of the pop-up structure, and the side baffle is unfolded based on the position where the bottom end of the side baffle is connected with the first connecting base.

This invention discloses the preparation and application of radiofrequency thermoresponsive platinum ion crosslinked black phosphorus nanogel. The nanogel has a core-shell structure, comprising a core composed of a radiofrequency thermosensitive agent and chemotherapeutic drugs, and a shell constructed from a thermosensitive nanopolymer. The thermosensitive nanogel BP-Pt@PNA prepared using the above components exhibits radiofrequency thermosensitive properties. Simultaneously, the introduction of the thermosensitive nanopolymer improves the stability of the radiofrequency thermosensitive agent and chemotherapeutic drugs, enabling long-term drug retention and fully leveraging the synergistic effect of non-invasive radiofrequency thermotherapy and chemotherapy. This drug-loaded nanogel can achieve multimodal treatment applications, including non-invasive radiofrequency thermotherapy-chemotherapy synergistic antitumor therapy and invasive radiofrequency ablation-chemotherapy-vascular embolization synergistic antitumor therapy, demonstrating significant clinical translational potential.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.

The invention relates to the technical field of phase change energy storage materials, in particular to a long-term energy storage phase change material and a preparation method thereof. The preparation method of the long-term energy storage phase change material provided by the invention comprises the following steps: adding polyol into a sodium carbonate solution, stirring and dissolving to obtain a first mixed solution; adding water into calcium chloride and polyacrylic acid, and mixing to obtain a second mixed solution; slowly adding the second mixed solution into the first mixed solution, violently stirring and cleaning to obtain the polyol hydrogel composite phase change material. The polyhydric alcohol hydrogel composite phase change material which can be stored for a long time and has good shape stability and heat storage performance is prepared by utilizing the method provided by the invention.

The invention discloses a PLGA (poly (lactic-co-glycolic acid))-minoxidil microneedle with near-infrared response and a preparation method of the PLGA-minoxidil microneedle. The PLGA-minoxidil microneedle with the near infrared response comprises PLGA-minoxidil microspheres, lanthanum hexaboride nanoparticles, a base body and a needle body, wherein the PLGA-minoxidil microspheres are arranged on the base body; wherein the PLGA-minoxidil microspheres and the lanthanum hexaboride nanoparticles are distributed in the needle body; and the base body and the needle body are made of a combination of PVA (polyvinyl alcohol) 1788 and PVA 1799. The PLGA-minoxidil microspheres are combined with the hydrogel microneedle with near-infrared response, controlled release of MXD is achieved on the microstructure through cooperation of the microporous structure of the microspheres and the near-infrared response effect of lanthanum hexaboride nanoparticles, the side effect of the medicine is effectively reduced, the concentration of the medicine in the body can be better maintained, and the drug delivery effect is improved. A better treatment effect is achieved; macroscopically, the prepared hydrogel system has relatively good mechanical properties, and can provide a stable drug delivery channel and drug delivery efficiency.

The invention discloses a preparation method of a high-bearing-capacity corrosion-resistant PAI / PTFE / BTO composite coating bottomed by terminated diisocyanate, and belongs to the technical field of functional coating materials. According to the technical scheme, the preparation method is characterized by comprising the following steps: carrying out surface modification on nano barium titanate by adopting gamma-aminopropyltriethoxysilane to obtain KH550 modified BTO; micron-sized PTFE is ground and dispersed through a conical mill; preparing a phenol-terminated diisocyanate bottoming solution; compounding the modified BTO, the dispersed PTFE and PAI resin, and performing ultrasonic dispersion to obtain a composite coating; the end-capped MDI priming solution is sprayed to a metal matrix to form a wetting layer, then the composite coating is sprayed, and the target coating is obtained through two-stage curing treatment. According to the coating, the low friction coefficient is kept, meanwhile, the bearing capacity, the wear resistance and the neutral salt mist resistance are remarkably improved, and the coating is suitable for metal friction pair surface protection under the severe working conditions of heavy loads, wet corrosion and the like.

The utility model relates to a pop-up support for fireworks and fireworks, and the pop-up support comprises a pop-up device (1), a fixing structure (2) arranged at the lower end of the pop-up device (1), and a bearing seat (3) arranged at the upper end of the pop-up device (1); the bearing seat (3) is provided with a plurality of accessory mounting structures (3a); the pop-up device (1) comprises a connecting sleeve (11), a telescopic column (12) and an elastic piece (13), wherein the connecting sleeve (11) and the telescopic column (12) are coaxially arranged in a sleeved mode, and the elastic piece (13) is arranged between the connecting sleeve (11) and the telescopic column (12). And when the pop-up device (1) is in a contracted state, the elastic piece (13) is in a compressed state. The pop-up support is achieved in a pop-up mode, loads (such as rotating fireworks) carried by the pop-up support can be conveniently and rapidly popped up, and diversity and ornamental value of firework setting-off are achieved.