30results about How to "Achieve controlled release" patented technology

The invention relates to the technical field of antibacterial materials, and provides a light-enzyme-heat synergistic antibacterial nano composite material and a preparation method thereof.The preparation method comprises the steps that 1, a copper-based chalcogenide with a plasma resonance effect serves as a structural template, a transition metal oxide intermediate layer and a bismuth oxyhalide epitaxial layer are sequentially constructed on the surface of the copper-based chalcogenide with the plasma resonance effect through a step-by-step continuous solvothermal method, and the copper-based chalcogenide with the plasma resonance effect serves as the structural template; forming a core-shell heterojunction with Z-type energy band matching; (2) pre-assembling a natural enzyme and a monatomic nano-enzyme in a buffer system to form a composite catalytic unit with an electron transfer channel; and (3) by taking the core-shell heterojunction as a polymerization core, under the precise temperature control condition of 0-10 DEG C, initiating active free radical polymerization through an interface, constructing a thermal response polymer shell layer on the surface of the heterojunction, and encapsulating the composite catalytic unit in a functional microdomain of a polymer network in situ. The anti-bacterial fabric can achieve a better synergistic anti-bacterial effect.

The invention discloses a biological agent for preventing and treating panax notoginseng root rot, and relates to the technical field of biological prevention and treatment, the biological agent is composed of four layers of functional florae: an A layer of sentinel-decoding flora is used for identifying a pathogen quorum sensing signal and is used as an event trigger source, a B layer of metabolic countering flora is used for decoupling conversion of disease-promoting saponin and controllable release of a metabolic false substrate, and a C layer of functional florae is used for controlling root rot of panax notoginseng. The C-layer self-healing conductive biological membrane construction flora forms a biological membrane with conductivity and self-healing capability on the root surface, and the D-layer electrically-enabled flora constructs stable biological micro-current at the rhizosphere by using ferric oxide particles as external electron acceptors. The layer A triggers to cause controlled release of the layer B, a conversion product of the layer B provides a carbon source and a structural unit for the layer C, and a conductive network of the layer C and the layer D form an electronic path. The biological agent is used for early recognition and continuous inhibition of pathogens in panax notoginseng planting soil, can start defense response in the early stage of quorum sensing signal occurrence, and keeps action stability under complex environmental conditions.

The invention discloses a dihydromyricetin enhanced gutta-percha / polylactic acid composite active packaging film and a preparation method thereof. According to the film, gutta-percha and polylactic acid are used as base materials, raspberry tea dihydromyricetin is used as an active component, and synergistic improvement of mechanical properties and biological activity is achieved. The specific preparation method comprises the following steps: dissolving gutta-percha in a first organic solvent to prepare a solution A; polylactic acid and a plasticizer are dissolved in a second organic solvent to prepare a solution B; and mixing the solution A and the solution B, adding dihydromyricetin, carrying out a stirring reaction, and carrying out film casting. The obtained film is faint yellow and semitransparent, the thickness is 30-40 microns, the tensile strength is larger than or equal to 33 MPa, the elongation at break is larger than or equal to 280%, and the good water vapor and oxygen barrier property is achieved. Benefited from the addition of dihydromyricetin, the film has remarkable bacteriostatic activity on escherichia coli and staphylococcus aureus, the DPPH free radical scavenging rate can reach 92.6%, the comprehensive performance is remarkably superior to that of a gutta-percha / polylactic acid composite film, and the gutta-percha / polylactic acid composite film has important application potential in the field of active packaging of food and agricultural products.

This invention belongs to the field of traditional Chinese medicine fermentation technology, specifically involving a high-enzyme-active Liu Shen Qu (a type of fermented medicinal herb) and its fermentation process. The process first processes red beans, bitter almonds, artemisia annua, cocklebur, and polygonum hydropiper into a medicinal porridge, which is then mixed with wheat flour and a specific fermenting agent to form a soft mass. Its innovation lies in the use of a Bacillus subtilis trehalose protective agent complex and Aspergillus oryzae chitosan microspheres. These two fermenting agents are prepared by spray drying encapsulation and ionogel methods, respectively, significantly improving the survival rate and stability of the fermenting microorganisms during processing and storage. The soft mass undergoes two stages of precisely controlled temperature and humidity fermentation, and finally, after shaping and segmented drying, the finished product is obtained. This process effectively solves the problems of low enzyme activity and poor stability in traditional Liu Shen Qu fermentation, resulting in a Liu Shen Qu product with high digestive enzyme activity and stable, uniform quality.

This invention relates to the field of polymer material additives, and discloses an environmentally friendly calcium-zinc composite PVC heat stabilizer and its preparation method. The heat stabilizer is a multi-level core-shell structure particle composed of three parts: (a) a functionalized hydrotalcite core intercalated with β-diketone and polyol; (b) a calcium / zinc metal soap inner shell chemically bonded to the core surface via a silane coupling agent; and (c) a lanthanum-organic complex outer shell coating the outermost layer containing unsaturated double bonds. The preparation method includes: preparing the functionalized core, grafting a silane coupling agent, in-situ co-precipitation to generate the inner shell, and solvent evaporation to coat the outer shell. This invention ensures the integrity of the composite particle structure and the synergistic effect of each component by constructing a stable chemical connection between the core and shell. Through intercalation and final chemical grafting, the migration and precipitation problems of the additives are fundamentally solved.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

The invention relates to the technical field of biomedical materials, in particular to a nano assembly for releasing NO through red light triggering and a preparation method and application of the nano assembly. The nano assembly is prepared from an amphiphilic block polymer with a polyethylene glycol hydrophilic end and a hydrophobic segment containing NO donor molecules and photocatalyst molecules through a hydrophilic and hydrophobic self-assembly forming method. Photocatalyst molecules in the amphiphilic block polymer are excited under irradiation of red light, decomposition of NO donor molecules can be triggered through an electron transfer process, and space-time controllable adjustment of NO release is achieved. The nano assembly has the red light response characteristic, excellent biological safety and antibacterial property, and has a wide application prospect in the aspects of antibiosis, anti-inflammation and the like. In addition, the red light has the characteristics of large tissue penetration depth and low phototoxicity, so that the problem that the penetration depth of the traditional ultraviolet light or blue light response NO donor molecular monomer is limited is effectively solved.

The application relates to a diaphragm and an electrochemical device and an electronic device comprising the same, and belongs to the technical field of electrochemical energy storage. The diaphragm provided by the application comprises a diaphragm base material and a solid-state ion source layer arranged on at least one side of the diaphragm base material, the solid-state ion source layer comprising lithium salt, a functional additive and an ion conductor composite, the ion conductor composite comprising a binder and an ion conductor; the lithium salt comprises at least one of lithium bisfluorosulfonylimide, lithium bis-trifluoromethanesulfonylimide, lithium difluoro(oxalato)borate, lithium tetrafluoroborate and lithium bis(oxalato)borate. The diaphragm provided by the application can be matched with a non-solute and low-viscosity electrolyte, the liquid injection time in preparation is reduced, the controllable release of lithium salt is realized, and the cycle stability and safety performance are improved.

The application discloses a preparation method of a multifunctional nano drug of Fe-based MOF loaded CM-272, and relates to a preparation method of an anti-cancer nano drug.The application aims at solving the problem that the CM-272 action is limited due to the internal hypoxic environment of a tumor.Method: I, preparing a Fe-based metal organic framework;II, preparing a MIL-53@CM-272 nano drug.The application is used for the preparation of the multifunctional nano drug of the Fe-based MOF loaded CM-272.

The application discloses a controllable cold energy releaser and a cold storage system, and belongs to the technical field of cold storage energy saving. The controllable cold energy releaser comprises a refrigeration mechanism, a container, a cold storage medium, air ducts and a cold energy release control mechanism. The container is internally provided with the cold storage medium. The container is open at both ends and is integrally provided with heat preservation blocks at the openings. The air ducts are arrayed in the container. The air ducts are penetrated through the heat preservation blocks on both sides and are connected with the cold energy release control mechanism. The refrigeration mechanism is connected with the container and is used for refrigerating the cold storage medium. The outer wall of the container is provided with a heat preservation material layer. The heat preservation material layer is used for blocking the cold energy exchange between the cold storage medium and the outside. The controllable cold energy releaser can realize the controllable release of the cold energy of the cold storage medium, so that the energy saving and consumption reducing effect is further improved, and the automatic management level is improved.

This research relates to the biomedical field and describes a thermosensitive hydrogel loaded with ginger extracellular vesicles and tannic acid, its preparation method, and its application in the preparation of anti-infective drugs. The process includes extracting ginger-derived extracellular vesicles; loading tannic acid onto these vesicles to obtain TA@GDEVs; preparing SP hydrogels; and slowly adding TA@GDEVs to the SP hydrogel to form a GTSP hydrogel system. GDEVs exhibit anti-inflammatory and pro-repair activities; TA provides broad-spectrum antibacterial, anti-inflammatory, and antioxidant functions; the SP hydrogel endows the thermosensitive hydrogel composite system with injectable and in-situ gelation properties; the SP hydrogel not only provides in-situ gelation and a protective barrier for GDEVs and TA but also enables controlled release of the loaded material; through synergistic effects, the three components enable the thermosensitive hydrogel composite system to possess responsiveness to the infection microenvironment, enhanced antibacterial efficacy, immune remodeling, and tissue repair functions, demonstrating its potential as a multifunctional anti-infective wound repair material.

This invention belongs to the field of biomedical technology, specifically disclosing an injectable embolic agent, its preparation method, and its application. The embolic agent is a hydrocolloid system containing core-shell structured nanoparticles: the core contains Cu... 2+ Salt and ATOX1 inhibitors, where ATOX1 inhibitors can inhibit copper ion efflux and promote intracellular copper accumulation, and interact with Cu 2+ It synergistically induces copper death in tumor cells; the shell is a thermosensitive block copolymer hydrogel that can interact with Cu. 2+ Coordination bonds are formed, enhancing the stability of nanoparticles, while a sol-gel transition occurs at physiological temperatures, enabling precise vascular embolization; the overall core-shell structure allows for the formation of Cu... 2+ The sustained-release effect of ATOX1 inhibitors was observed. In the VX2 rabbit hepatocellular carcinoma model, this embolization agent significantly improved tumor necrosis rate and reduced metastasis rate compared to traditional iodized oil embolization; it also downregulated hypoxia- and angiogenesis-related factors such as HIF-1α, VEGF, and CD31, inhibited MMP9-mediated tumor invasion and metastasis, and promoted CD8+. + T-cell infiltration effectively improves the tumor immunosuppressive microenvironment after transarterial chemoembolization.

The invention discloses a photoelectric microneedle system with bionic electrical stimulation and drug controlled release functions, comprising: a silicon film which is a silicon film array of two different doping types; the hydrogel microneedle is arranged on the surface of the silicon film, and the hydrogel microneedle contains medicine. By arranging semiconductor films with different polarities in an array mode, a photo-generated electric field with the adjustable direction can be generated under illumination, the direction of the photo-generated electric field is kept consistent with an endogenous electric field formed after tissue damage, and therefore wireless, accurate and controllable bionic electrical stimulation is achieved. Different doping types of semiconductor films generate different-direction electric fields under illumination, and directional migration and on-demand release of drug molecules with different charge properties can be realized. The photogenerated electric field not only can simulate and enhance endogenous electric signals after skin injury and regulate and control cell migration, proliferation and reconstruction processes, but also can synchronously drive drugs to be accurately released from the microneedle hydrogel.

This invention discloses a near-infrared light-responsive thermo-electrically coupled titanium-based implant, its preparation method, and its application, belonging to the field of biomedical materials technology. The near-infrared light-responsive thermo-electrically coupled titanium-based implant provided by this invention comprises a porous titanium substrate and a composite hydrogel coating; the surface of the porous titanium substrate is sequentially disposed from the inside out with TiO2 / SrTiO3 heterojunctions, upconversion nanoparticles, and barium titanate nanoparticles; the upconversion nanoparticles are Yb. 3+ and Er 3+ Co-doped NaYF4 upconversion nanoparticles; a composite hydrogel coating is deposited on the surface of barium titanate nanoparticles, the composite hydrogel coating comprising MXene, pharmaceutically active ingredients, and a hydrogel carrier. This invention achieves synergistic coupling of photothermal and photoelectric-pyroelectric effects under near-infrared light irradiation by constructing a multi-layered synergistic structure on a porous titanium substrate, thereby synergistically realizing multiple functions such as promoting bone growth, antibacterial activity, and antitumor activity.

This invention discloses the preparation and application of radiofrequency thermoresponsive platinum ion crosslinked black phosphorus nanogel. The nanogel has a core-shell structure, comprising a core composed of a radiofrequency thermosensitive agent and chemotherapeutic drugs, and a shell constructed from a thermosensitive nanopolymer. The thermosensitive nanogel BP-Pt@PNA prepared using the above components exhibits radiofrequency thermosensitive properties. Simultaneously, the introduction of the thermosensitive nanopolymer improves the stability of the radiofrequency thermosensitive agent and chemotherapeutic drugs, enabling long-term drug retention and fully leveraging the synergistic effect of non-invasive radiofrequency thermotherapy and chemotherapy. This drug-loaded nanogel can achieve multimodal treatment applications, including non-invasive radiofrequency thermotherapy-chemotherapy synergistic antitumor therapy and invasive radiofrequency ablation-chemotherapy-vascular embolization synergistic antitumor therapy, demonstrating significant clinical translational potential.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.

The invention discloses a preparation method of a high-bearing-capacity corrosion-resistant PAI / PTFE / BTO composite coating bottomed by terminated diisocyanate, and belongs to the technical field of functional coating materials. According to the technical scheme, the preparation method is characterized by comprising the following steps: carrying out surface modification on nano barium titanate by adopting gamma-aminopropyltriethoxysilane to obtain KH550 modified BTO; micron-sized PTFE is ground and dispersed through a conical mill; preparing a phenol-terminated diisocyanate bottoming solution; compounding the modified BTO, the dispersed PTFE and PAI resin, and performing ultrasonic dispersion to obtain a composite coating; the end-capped MDI priming solution is sprayed to a metal matrix to form a wetting layer, then the composite coating is sprayed, and the target coating is obtained through two-stage curing treatment. According to the coating, the low friction coefficient is kept, meanwhile, the bearing capacity, the wear resistance and the neutral salt mist resistance are remarkably improved, and the coating is suitable for metal friction pair surface protection under the severe working conditions of heavy loads, wet corrosion and the like.

The invention relates to the technical field of pipes, in particular to a functional master batch for a high-weather-resistance and high-antifouling net cage pipe as well as a preparation method and application of the functional master batch. The invention relates to a functional master batch for a high-weather-resistance and high-antifouling net cage pipe. The functional master batch for the high-weather-resistance and high-antifouling net cage pipe is prepared from the following raw material components: a flexible solubilizer, a functional filler, a weather-resistant master batch and a functional antifouling agent, the functional filler is titanium dioxide coated hollow glass beads of which the surfaces are modified by a silane coupling agent; the weather-resistant master batch comprises the following raw materials: polyethylene, a light stabilizer, an antioxidant and carbon black. The functional master batch for the high-weather-resistance and high-antifouling net cage pipe has the characteristics of good antifouling property, good weather resistance, long-acting antifouling property and excellent mechanical property of the net cage pipe; the technical problems that an existing net cage pipe is insufficient in weather resistance, fast in heat absorption, high in temperature, prone to degradation in mechanical property and poor in antifouling durability, and the mechanical property and the antifouling property of the net cage pipe are contradictory are solved.

The invention discloses a preparation method of a limestone-fired clay low-carbon cement-based strong-hydrophobicity high-chlorine-resistance steel bar coating, which comprises the following steps: (1) adding stearate into a methanol dispersion liquid of a double-ligand carrier material, stirring, adding tetraethoxysilane, and continuously stirring for reaction to obtain a slow-release hydrophobic molecule modifier; (2) activating the argillaceous solid waste heat, quenching the argillaceous solid waste heat to room temperature, and grinding the product to obtain activated clay powder; and uniformly mixing the calcined clay with cement clinker, limestone powder and gypsum to obtain the limestone-calcined clay low-carbon cement. And (3) uniformly mixing the slow-release hydrophobic molecule modifier, limestone-fired clay low-carbon cement and water to obtain the steel bar coating. Through the synergistic effect of the limestone-fired clay low-carbon cement and the slow-release hydrophobic molecule modifier, a uniform and stable hydrophobic chlorine-resistant gel network is constructed, the strong hydrophobic and high chlorine-resistant effects are achieved, and the protection effect on the reinforcing steel bars is effectively improved.

The utility model relates to the technical field of auxiliary dashboard plating resistance, and discloses an auxiliary dashboard electroplated part plating resistance device which comprises a paint storage box, an anti-blocking pin row and a fixing rod, the anti-blocking pin row is arranged at the bottom of the paint storage box, two opposite inner walls in the anti-blocking pin row are correspondingly connected with the side walls of the paint storage box in a sliding fit mode, and the fixing rod is connected with the paint storage box in a sliding fit mode. And fixing rods are arranged on the two opposite side edges of the anti-blocking pin row and the paint storage box correspondingly, the two fixing rods symmetrically penetrate through the paint storage box and the anti-blocking pin row, the anti-plating device for the auxiliary instrument board electroplated part can effectively conduct anti-blocking treatment on the paint spraying head, and the follow-up using effect and the anti-plating paint spraying quality are improved.

The invention discloses a bioactive medical tissue sealant as well as a preparation method and application thereof. Specifically, the medical tissue sealant is prepared from the following raw materials: a polyethylene glycol derivative and a blood product, the blood product contains a blood component and an anticoagulant, the blood component is human or animal blood or powder prepared from the blood, and the molecular weight range of the polyethylene glycol derivative is 2-100 kDa. The tissue sealant prepared by the invention has high-strength mechanical support (the compression strength is greater than or equal to 20 MPa) and lasting interface adhesive force (the shear strength is greater than or equal to 90 kPa), and not only can adapt to the change of dynamic wound mechanical stress, but also can realize controllable release of bioactive components; the method has wide application prospects in the clinical fields of hemostasis, wound repair, tissue regeneration, chronic wound treatment and the like.

The application belongs to the technical field of soil improvement, and relates to an enhanced double-layer coated nanomineral soil conditioner and a preparation method thereof, and specifically comprises the following steps: mixing a nanomineral and a natural polymer material in a reaction system according to a mass ratio to form a core-shell material; and mixing and stirring the core-shell material and a polymer hydrogel, and obtaining the double-layer coated soil conditioner after drying. The conditioner is double-modified by the natural polymer and the hydrogel, effectively prevents agglomeration and inactivation of the nanomineral, and improves the dispersibility and long-term stability of the nanomineral in soil. Meanwhile, the porous and light structure of the conditioner can improve soil aggregate structure, water retention and porosity, promote microbial diversity, and realize synergistic effect of carbon sequestration and soil improvement. The raw materials of the application are environmentally friendly, the preparation process is mild and has strong universality, the application has a slow-release property, can significantly improve soil organic matter content and crop yield, and is suitable for agricultural soil improvement and carbon sequestration.

This invention provides a composite hydrogel material, its preparation method and application, and a system and method for hydrogen adsorption-storage-release, relating to the field of hydrogen separation and recovery technology. The composite hydrogel material provided by this invention achieves selective adsorption of hydrogen through MOF-808 (Zr) nanoparticles with a pore size of 0.29~0.3 nm. Hydrogen is selectively adsorbed, while methane is blocked by the kinetic quantum sieving effect. After adsorption saturation, the hydrophobic groups of the thermosensitive polymer trigger the hydrophobic shrinkage of the composite hydrogel material, forming a closed hydrogen storage unit, thus achieving hydrogen storage. The local surface plasmon resonance peak of the gold nanorods dispersed in the thermosensitive copolymer is 798~818 nm. Under near-infrared light irradiation of the corresponding wavelength, the thermosensitive copolymer dissolves, initiating a phase transition in the composite gel core, achieving controlled hydrogen release. The silicon carbide layer serves as an outer shell, providing strong resistance to hydrogen sulfide corrosion.

The application relates to a drug controlled release system with a chiral drug selective loading function, a preparation method and application thereof, and belongs to the technical field of biological medicines. The drug controlled release system with the chiral drug selective loading function is prepared into a supermolecular hydrogel selective loading system after a gel factor is self-assembled into a supermolecular hydrogel, and chiral drugs with the same optical rotation as the supermolecular hydrogel are loaded into a three-dimensional network structure of the supermolecular hydrogel. The drug controlled release system with the chiral drug selective loading function prepared by the application can realize selective loading of different configurations of naproxen, and can realize controlled release of S-naproxen under alkaline conditions. The chiral selective controlled release system is simple in preparation, high in feasibility, and can be widely applied to the field of biological medicines.

The application discloses a temperature-sensitive liposome hydrogel for targeting controllable release of a drug carrier and a preparation method and application thereof, and belongs to the field of liposome hydrogels.The method comprises the following steps: (1) dispersing polysaccharide in water, then adding polyvinyl alcohol, stirring uniformly, and then freezing / thawing the obtained mixed solution for multiple times to obtain a physically cross-linked hydrogel, and then eluting and soaking the hydrogel to obtain the hydrogel; (2) uniformly oscillating a liposome emulsion and the hydrogel, and obtaining the liposome hydrogel through centrifugation and freeze-drying.The application solves the problems that the liposome as a drug carrier is influenced by external environment and temperature conditions, and the targeting characteristics for some diseases are not ideal, and the phenomena of drug leakage and poor effect are caused.The application also realizes the effects of controllable release of a drug and improvement of drug bioavailability, and has a higher drug release amount at a temperature of 42 DEG C.

The application discloses polyglucuronate-selenocystamine phenylboronic pinacol ester or a salt thereof, a preparation method and application. The preparation method comprises the following steps: (1) polyglucuronate or a salt thereof is reacted with selenocystamine to synthesize polyglucuronate-selenocystamine or a salt thereof; (2) polyglucuronate-selenocystamine or the salt thereof is reacted with 4-(hydroxymethyl) phenylboronic pinacol ester through an amide reaction to synthesize polyglucuronate-selenocystamine phenylboronic pinacol ester or a salt thereof; and (3) a protein thrombolytic drug is loaded by an ultrasonic homogenization method to prepare active oxygen-responsive nanogel. The active oxygen-responsive nanogel is combined with P-selectin, so that the active oxygen-responsive nanogel has targeting property for activated platelets at a thrombus site, the purpose of targeted drug delivery and reduced side effects is achieved, the drug is effectively enriched at the thrombus site, the active oxygen microenvironment at an ischemic cerebral stroke site is adjusted, the occurrence of ischemic cerebral stroke infarction is reduced, and a new strategy is provided for clinical treatment of ischemic cerebral stroke.

This invention relates to the field of medical technology, specifically to an injectable antioxidant hydrogel adapted to the mechanical properties of the nucleus pulposus, its preparation method, and its applications. The hydrogel uses a polypeptide-polymer copolymer as its backbone, and by adjusting the polymer network structure to match the mechanical properties of the nucleus pulposus, it achieves synergistic optimization of antioxidant properties, mechanical support, and biocompatibility. Because it does not rely on any drug bioactive factors, it can also effectively solve the problems of burst release and over-release of loaded drugs, exhibiting excellent overall performance and possessing broad market application potential.

This invention relates to the field of medical device manufacturing technology, and in particular to a method for preparing a composite material stent and the stent made therefrom. The method includes the following steps: Step S1, preparation of magnesium alloy tubing and initial processing of the skeleton; Step S2, surface pretreatment of the skeleton; Step S3, construction of an intermediate bonding layer; Step S4, coating with a PLLA outer layer; Step S5, molding and post-processing; Step S6, final inspection and sterilization. This invention achieves synergistically enhanced mechanical properties. The magnesium alloy core provides strong initial support, while the PLLA outer layer provides supplementary support. It also exhibits controllable degradation performance; the PLLA outer layer effectively delays the corrosion of the magnesium alloy by chloride ions and other substances in body fluids, extending the support time. The PLLA outer layer isolates the magnesium alloy from direct contact with blood, further reducing the risk of thrombosis. The specially designed intermediate bonding layer structure ensures the structural integrity of the stent during its service life.

The application belongs to the technical field of microbial fertilizer, and particularly relates to an environment-friendly biological organic fertilizer and a preparation method thereof.The environment-friendly biological organic fertilizer comprises the following raw materials in parts by weight: 70-90 parts of fermented organic matter, 8-13 parts of microbial agent and 10-15 parts of coated suspension.The test results show that after the environment-friendly biological organic fertilizer is applied to soil, the growth of crops can be effectively promoted, the yield of crops is improved, the nutritional quality and edible safety of crop fruits are significantly improved, and the environment-friendly biological organic fertilizer has a wide application prospect.

The invention provides a latent curing agent containing dynamic imine bonds for modifying epoxy asphalt and a preparation method of the latent curing agent. The latent curing agent takes terephthalaldehyde and polyether amine D400 as raw materials, a prepolymer containing dynamic imine bonds is formed through an imidization reaction, and amido in the prepolymer is sealed by adopting a sealing system composed of cyclohexanone and acetone. The preparation method comprises an imidization reaction with segmented heating and a ketone blocking reaction carried out step by step. By utilizing the environmental responsiveness of the dynamic imine bond and a closed synergistic release mechanism, the construction pot life of the epoxy asphalt is prolonged to 120 minutes or more, the room-temperature storage stability is improved to 6 months or more, the self-adaptive regulation and control of the curing speed on temperature and humidity conditions are realized, and meanwhile, the mechanical property of a cured material is improved.