12results about How to "Achieve controlled release" patented technology

This invention belongs to the field of traditional Chinese medicine fermentation technology, specifically involving a high-enzyme-active Liu Shen Qu (a type of fermented medicinal herb) and its fermentation process. The process first processes red beans, bitter almonds, artemisia annua, cocklebur, and polygonum hydropiper into a medicinal porridge, which is then mixed with wheat flour and a specific fermenting agent to form a soft mass. Its innovation lies in the use of a Bacillus subtilis trehalose protective agent complex and Aspergillus oryzae chitosan microspheres. These two fermenting agents are prepared by spray drying encapsulation and ionogel methods, respectively, significantly improving the survival rate and stability of the fermenting microorganisms during processing and storage. The soft mass undergoes two stages of precisely controlled temperature and humidity fermentation, and finally, after shaping and segmented drying, the finished product is obtained. This process effectively solves the problems of low enzyme activity and poor stability in traditional Liu Shen Qu fermentation, resulting in a Liu Shen Qu product with high digestive enzyme activity and stable, uniform quality.

This invention relates to the field of polymer material additives, and discloses an environmentally friendly calcium-zinc composite PVC heat stabilizer and its preparation method. The heat stabilizer is a multi-level core-shell structure particle composed of three parts: (a) a functionalized hydrotalcite core intercalated with β-diketone and polyol; (b) a calcium / zinc metal soap inner shell chemically bonded to the core surface via a silane coupling agent; and (c) a lanthanum-organic complex outer shell coating the outermost layer containing unsaturated double bonds. The preparation method includes: preparing the functionalized core, grafting a silane coupling agent, in-situ co-precipitation to generate the inner shell, and solvent evaporation to coat the outer shell. This invention ensures the integrity of the composite particle structure and the synergistic effect of each component by constructing a stable chemical connection between the core and shell. Through intercalation and final chemical grafting, the migration and precipitation problems of the additives are fundamentally solved.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

The application discloses a controllable cold energy releaser and a cold storage system, and belongs to the technical field of cold storage energy saving. The controllable cold energy releaser comprises a refrigeration mechanism, a container, a cold storage medium, air ducts and a cold energy release control mechanism. The container is internally provided with the cold storage medium. The container is open at both ends and is integrally provided with heat preservation blocks at the openings. The air ducts are arrayed in the container. The air ducts are penetrated through the heat preservation blocks on both sides and are connected with the cold energy release control mechanism. The refrigeration mechanism is connected with the container and is used for refrigerating the cold storage medium. The outer wall of the container is provided with a heat preservation material layer. The heat preservation material layer is used for blocking the cold energy exchange between the cold storage medium and the outside. The controllable cold energy releaser can realize the controllable release of the cold energy of the cold storage medium, so that the energy saving and consumption reducing effect is further improved, and the automatic management level is improved.

This invention belongs to the field of biomedical technology, specifically disclosing an injectable embolic agent, its preparation method, and its application. The embolic agent is a hydrocolloid system containing core-shell structured nanoparticles: the core contains Cu... 2+ Salt and ATOX1 inhibitors, where ATOX1 inhibitors can inhibit copper ion efflux and promote intracellular copper accumulation, and interact with Cu 2+ It synergistically induces copper death in tumor cells; the shell is a thermosensitive block copolymer hydrogel that can interact with Cu. 2+ Coordination bonds are formed, enhancing the stability of nanoparticles, while a sol-gel transition occurs at physiological temperatures, enabling precise vascular embolization; the overall core-shell structure allows for the formation of Cu... 2+ The sustained-release effect of ATOX1 inhibitors was observed. In the VX2 rabbit hepatocellular carcinoma model, this embolization agent significantly improved tumor necrosis rate and reduced metastasis rate compared to traditional iodized oil embolization; it also downregulated hypoxia- and angiogenesis-related factors such as HIF-1α, VEGF, and CD31, inhibited MMP9-mediated tumor invasion and metastasis, and promoted CD8+. + T-cell infiltration effectively improves the tumor immunosuppressive microenvironment after transarterial chemoembolization.

This invention discloses a near-infrared light-responsive thermo-electrically coupled titanium-based implant, its preparation method, and its application, belonging to the field of biomedical materials technology. The near-infrared light-responsive thermo-electrically coupled titanium-based implant provided by this invention comprises a porous titanium substrate and a composite hydrogel coating; the surface of the porous titanium substrate is sequentially disposed from the inside out with TiO2 / SrTiO3 heterojunctions, upconversion nanoparticles, and barium titanate nanoparticles; the upconversion nanoparticles are Yb. 3+ and Er 3+ Co-doped NaYF4 upconversion nanoparticles; a composite hydrogel coating is deposited on the surface of barium titanate nanoparticles, the composite hydrogel coating comprising MXene, pharmaceutically active ingredients, and a hydrogel carrier. This invention achieves synergistic coupling of photothermal and photoelectric-pyroelectric effects under near-infrared light irradiation by constructing a multi-layered synergistic structure on a porous titanium substrate, thereby synergistically realizing multiple functions such as promoting bone growth, antibacterial activity, and antitumor activity.

This invention discloses the preparation and application of radiofrequency thermoresponsive platinum ion crosslinked black phosphorus nanogel. The nanogel has a core-shell structure, comprising a core composed of a radiofrequency thermosensitive agent and chemotherapeutic drugs, and a shell constructed from a thermosensitive nanopolymer. The thermosensitive nanogel BP-Pt@PNA prepared using the above components exhibits radiofrequency thermosensitive properties. Simultaneously, the introduction of the thermosensitive nanopolymer improves the stability of the radiofrequency thermosensitive agent and chemotherapeutic drugs, enabling long-term drug retention and fully leveraging the synergistic effect of non-invasive radiofrequency thermotherapy and chemotherapy. This drug-loaded nanogel can achieve multimodal treatment applications, including non-invasive radiofrequency thermotherapy-chemotherapy synergistic antitumor therapy and invasive radiofrequency ablation-chemotherapy-vascular embolization synergistic antitumor therapy, demonstrating significant clinical translational potential.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.

The application belongs to the technical field of soil improvement, and relates to an enhanced double-layer coated nanomineral soil conditioner and a preparation method thereof, and specifically comprises the following steps: mixing a nanomineral and a natural polymer material in a reaction system according to a mass ratio to form a core-shell material; and mixing and stirring the core-shell material and a polymer hydrogel, and obtaining the double-layer coated soil conditioner after drying. The conditioner is double-modified by the natural polymer and the hydrogel, effectively prevents agglomeration and inactivation of the nanomineral, and improves the dispersibility and long-term stability of the nanomineral in soil. Meanwhile, the porous and light structure of the conditioner can improve soil aggregate structure, water retention and porosity, promote microbial diversity, and realize synergistic effect of carbon sequestration and soil improvement. The raw materials of the application are environmentally friendly, the preparation process is mild and has strong universality, the application has a slow-release property, can significantly improve soil organic matter content and crop yield, and is suitable for agricultural soil improvement and carbon sequestration.

This invention relates to the field of medical technology, specifically to an injectable antioxidant hydrogel adapted to the mechanical properties of the nucleus pulposus, its preparation method, and its applications. The hydrogel uses a polypeptide-polymer copolymer as its backbone, and by adjusting the polymer network structure to match the mechanical properties of the nucleus pulposus, it achieves synergistic optimization of antioxidant properties, mechanical support, and biocompatibility. Because it does not rely on any drug bioactive factors, it can also effectively solve the problems of burst release and over-release of loaded drugs, exhibiting excellent overall performance and possessing broad market application potential.

This invention relates to the field of medical device manufacturing technology, and in particular to a method for preparing a composite material stent and the stent made therefrom. The method includes the following steps: Step S1, preparation of magnesium alloy tubing and initial processing of the skeleton; Step S2, surface pretreatment of the skeleton; Step S3, construction of an intermediate bonding layer; Step S4, coating with a PLLA outer layer; Step S5, molding and post-processing; Step S6, final inspection and sterilization. This invention achieves synergistically enhanced mechanical properties. The magnesium alloy core provides strong initial support, while the PLLA outer layer provides supplementary support. It also exhibits controllable degradation performance; the PLLA outer layer effectively delays the corrosion of the magnesium alloy by chloride ions and other substances in body fluids, extending the support time. The PLLA outer layer isolates the magnesium alloy from direct contact with blood, further reducing the risk of thrombosis. The specially designed intermediate bonding layer structure ensures the structural integrity of the stent during its service life.

The application belongs to the technical field of microbial fertilizer, and particularly relates to an environment-friendly biological organic fertilizer and a preparation method thereof.The environment-friendly biological organic fertilizer comprises the following raw materials in parts by weight: 70-90 parts of fermented organic matter, 8-13 parts of microbial agent and 10-15 parts of coated suspension.The test results show that after the environment-friendly biological organic fertilizer is applied to soil, the growth of crops can be effectively promoted, the yield of crops is improved, the nutritional quality and edible safety of crop fruits are significantly improved, and the environment-friendly biological organic fertilizer has a wide application prospect.