11results about How to "Regulated release rate" patented technology

The invention belongs to the technical field of veterinary preparations, and particularly relates to a tilmicosin premix and a preparation method thereof. The tilmicosin premix is prepared from the following raw materials: tilmicosin, a polylactic acid-glycolic acid copolymer, lecithin, modified hydroxypropyl methyl cellulose, grafted polyvinylpyrrolidone, polyethylene glycol and an antioxidant, a solid dispersion is formed through lecithin and grafted polyvinylpyrrolidone, the solubility and stability of tilmicosin are enhanced, polylactic acid-glycolic acid copolymer nano-microspheres are prepared through a double-emulsion solvent evaporation method, slow release of drugs is achieved, dodecyl modified hydroxypropyl methyl cellulose and polyethylene glycol are combined, and the sustained release effect is achieved. The solubility and the slow release characteristic are further enhanced. The activity of the granular premix is effectively preserved, and the granular premix is convenient to use and transport.

The invention relates to a preparation method of a sodium alginate composite hydrogel microneedle for treating pathological scars, and belongs to the technical field of hydrogel microneedles, the microneedle takes sodium alginate as a main material, the sodium alginate is methylated to obtain methylacryloylated sodium alginate AlgMA, hollow manganese dioxide nanoparticles loaded with matrix metalloproteinase are added, and the microneedle is prepared by a hydrothermal method. A hydrogel microneedle filling solution is obtained; the preparation method comprises the following steps: transferring the hydrogel microneedle into a PDMS microneedle mold, carrying out negative pressure vacuum bubble removal, drying and concentrating twice in a drying oven, carrying out photopolymerization crosslinking, forming a solid hydrogel microneedle tip, adding a 20% PVA solution, and drying in the drying oven to form the microneedle substrate, and the preparation method is simple, convenient and efficient, has industrial application potential, and is suitable for the scenes of drug delivery, skin care and the like; according to the application of the sodium alginate composite hydrogel microneedle in pathological scar drug delivery, the sodium alginate composite hydrogel microneedle has excellent mechanical strength and biocompatibility, and painless and noninvasive drug delivery can be carried out on the surface of scar skin.

The invention relates to a preparation method and application of a coating essential oil-loaded zeolite molecular sieve with water burst release performance. Specifically, the essential oil-loaded zeolite molecular sieve is provided, and the essential oil-loaded zeolite molecular sieve is prepared from essential oil and a zeolite molecular sieve, the coating essential oil-loaded zeolite molecular sieve further comprises a coating, the coating is prepared by coating with a coating solution, and the coated essential oil-loaded zeolite molecular sieve is a coating essential oil-loaded zeolite molecular sieve. The coating essential oil-loaded zeolite molecular sieve with the water burst release performance is very slow in release under the condition of normal temperature, can realize uniform release under certain temperature and humidity, has the burst release performance under the condition of water, and can be used for preparing the coating essential oil-loaded zeolite molecular sieve with the water burst release performance. The coating essential oil-loaded zeolite molecular sieve prepared by the invention provides very beneficial help for the application of the coating essential oil-loaded zeolite molecular sieve in products such as paper diapers and the like. Meanwhile, the preparation method of the coating essential oil-loaded zeolite molecular sieve is simple, the raw materials are easy to obtain, the cost is low, and the coating essential oil-loaded zeolite molecular sieve is very suitable for commercial production.

The invention discloses a hydrogen sulfide responsive carbon monoxide donor molecule as well as a preparation method and application thereof. The hydrogen sulfide responsive carbon monoxide donor molecule has the following structure: # imgabs 0 #, R1, R2, R3 and R4 are respectively and independently selected from groups with electron withdrawing property, groups with electron donating property or hydrogen atoms, and X is selected from O or # imgabs 1 #. Acyloxydiene-Fe (CO) 3 is selected as an element for releasing carbon monoxide and an azido group is selected as a hydrogen sulfide response element, so that the formed donor molecule has hydrogen sulfide responsiveness and can release carbon monoxide in the presence of hydrogen sulfide, and the hydrogen sulfide response rate and the release rate of carbon monoxide of the donor material can be adjusted; therefore, the treatment on the colitis and the inhibition on the colorectal cancer can be realized.

The application provides a groove structure and a medical stent. The groove structure comprises a body, a groove and a drug coating. The groove is located on the body. A part of the outer surface of the body forms a shoulder, and the shoulder is located at at least one side of the opening of the groove. A part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. In this way, a part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. An operator can control the contact area of the drug coating with the vascular tissue by adjusting the drug loading of the shoulder and the thickness of the drug coating in the groove, thereby controlling the release rate of the drug coating.

The present invention discloses a drug sustained-release tablet and a preparation method thereof. The preparation method of the drug sustained-release tablet adopts direct powder compression or dry granulation for preparation, and the preparation process does not include a heating step; the raw materials of the drug sustained-release tablet include a lipid material, a hydrophobic lubricant and a highly soluble drug; wherein the lipid material includes a waxy material, and the particle size D90 of the waxy material is less than 150 μm; and the raw materials do not contain a solvent. In the present invention, no additional solvent is introduced, and no heating is required, and a drug sustained-release tablet of qualified quality can be well prepared, the process is simple, the production efficiency is high, and the active pharmaceutical ingredient in the drug sustained-release tablet is stable.

The invention provides a quercetin-based polyurethane material, a novel metal-ligand coordination cross-linked polyurethane material and a preparation method and application of the quercetin-based polyurethane material and belongs to the technical field of polyurethane materials, and the structural formula of the novel metal-ligand coordination cross-linked polyurethane material is shown in the specification. The preparation method comprises the following steps: adding diisocyanate into a completely molten dihydric alcohol oligomer system, and reacting to obtain an isocyanate-terminated prepolymer; adding a quercetin solution into the prepolymer system, and reacting to obtain a quercetin-based polyurethane solution; and adding a metal ion solution into the quercetin-based polyurethane solution system, and volatilizing the solvent after the reaction to obtain the novel metal-ligand coordination cross-linked polyurethane material. According to the invention, oligomer dihydric alcohol is taken as a soft segment, quercetin is taken as a chain extender, and a polyurethane material containing quercetin in a main chain and a metal-ligand coordinated cross-linked polyurethane material are synthesized by a one-pot method; wherein the metal ions are used as cross-linking points to be connected with a polyurethane main chain, so that a more flexible network structure is formed.

The present invention relates to the field of bioengineering pharmaceutical technology, and in particular to a pharmaceutical preparation for alleviating the progression of hyperuricemia nephropathy and a preparation method thereof, wherein the pharmaceutical preparation for alleviating the progression of hyperuricemia nephropathy is composed of a co-crystal formed by febuxostat, p-aminobenzoic acid and salicylic acid, and an emulsion system constructed by isopropyl stearate, polyethylene glycolized lecithin and modified hydroxyethyl cellulose. The present invention utilizes febuxostat, p-aminobenzoic acid and salicylic acid to form a co-crystal, optimizes drug solubility and bioavailability through a hydrogen bond network, enhances stability and reduces irritation. Polyethylene glycolized lecithin and carboxymethylated hydroxyethyl cellulose act synergistically, the former reduces interfacial tension and stabilizes the emulsion, and the latter enhances dispersion stability through hydrogen bonds, regulates the release rate, and achieves efficient sustained release.

The present invention discloses a sterilization iodophor compound composition and a processing technology thereof, and relates to the technical field of sterilization, xanthan gum is added into deionized water, stirring is performed until complete dissolution, cooling is performed, glycerol and an amino-polyethylene glycol-polyacrylic acid block copolymer are added, stirring is performed until complete dissolution, povidone iodine is added, stirring is performed until complete dissolution, and the sterilization iodophor compound composition is obtained. And adding the microcapsule solution, adding deionized water, stirring, keeping out of light, standing and filtering to obtain the iodophor compound composition for sterilization. The povidone iodine can oxidize and destroy bacterial protein and nucleic acid by providing free iodine, so that a broad-spectrum bactericidal effect is achieved; thymol and eugenol destroy bacterial cell membranes and cell walls and inhibit key enzyme activity so as to realize a bactericidal effect; tannic acid is combined with protein to form a compound on a cell membrane to destroy the membrane function of the cell membrane; through the synergistic effect of the three components, the sterilization effect of the iodophor compound composition for sterilization is improved.

The invention discloses a multifunctional two-section microneedle containing an intelligent nano-carrier and a preparation method and application of the multifunctional two-section microneedle, and belongs to the technical field of medical instrument preparation. The preparation method specifically comprises the following steps: firstly, constructing a pH-responsive drug carrier chitosan nanoparticle by using an ionic crosslinking assembly method, then modifying gelatin and chitosan by using methacrylic anhydride, mixing the gelatin, the chitosan and the methacrylic anhydride to prepare a microneedle tip precursor solution, dropwise adding the microneedle tip precursor solution onto a microneedle mold, exhausting air in a vacuum environment, and performing vacuum drying to obtain the pH-responsive drug carrier chitosan nanoparticle micro-needle. The preparation method comprises the following steps: adding a cross-linking agent into a mold, cross-linking under ultraviolet light, drying to obtain a needle tip part, adding a gelatin-polydopamine solution above the needle tip part to form a substrate part, putting the mold into a drying box, drying overnight, and demolding to obtain the two-section microneedle. The two-section microneedle prepared by the invention has excellent capability of resisting common bacteria and promoting healing of postoperative infected wounds. The technical problem that in the prior art, a microneedle lacks intelligent drug response release and wound self-repairing promoting capacity is solved.

The invention discloses a preparation method of an efficient compound antioxidant for animal fat and fat products, the formula of the antioxidant takes a fat-soluble rosemary extract, a water-soluble rosemary extract and other plant extracts as main components, and all the components play a maximum synergistic effect; the fat-soluble rosemary extract is subjected to simple and effective impurity removal treatment, so that bitter and astringent components mainly containing oleoresin and volatile oil components mainly containing rosemary oil are removed; in addition, water-soluble rosemary extracts and other plant extracts are subjected to precipitation, impurity removal and microencapsulation treatment so as to reduce bitter taste, astringent taste and smell. The fat-soluble rosemary extract, the water-soluble rosemary extract and other natural antioxidants, which are treated by the low-processing-cost process, are compounded for use, so that an excellent antioxidation effect can be achieved in the field of oil-water coexisting animal fat, and the flavor of the animal fat and fat products cannot be influenced.