105results about How to "Regulated release rate" patented technology

The present invention relates to polymeric nanoparticles, particularly useful in drug and agent delivery, as well as for imaging and diagnosis. The polymeric nanoparticles of the present invention comprise cross-linkers that, when degraded, leave simple linear polymeric molecules that can be excreted by the body. The present invention also relates to methods of producing the polymeric nanoparticles of the present invention, and methods of using them in drug and agent delivery, as well as imaging and diagnosis.

The invention relates to a release-controllable antibiotic hydrogel and a preparation method and application thereof. The release-controllable antibiotic hydrogel based on aminoglycoside antibiotics is formed by crosslinking the oxidized polysaccharide macromolecules and the aminoglycoside antibiotics through acid-sensitive schiff base groups; the schiff base bonds are broken under the acid environment produced by bacteria infection, so that the gel is degraded, and the antibiotics is released according to requirements. The invention also provides antibacterial application of the oxidized polysaccharide-aminoglycoside antibiotics hydrogel in vitro and in vivo. The release-controllable antibiotic hydrogel has the advantages that the preparation is simple, and the cost is low; the strength, shape and degrading of the gel, the medicine release rate and the like can be controlled according to the content of antibiotics, the broad-spectrum high-efficiency antibacterial property is realized, and the antibacterial effect is better than the antibacterial effect of multiple types of commercial antibacterial gels on market; the hydrogel may be prepared into creams, implants and medical apparatus coatings, so as to resist the infection by gram-negative bacterium, gram-positive bacterium and the like.

The invention relates to a high temperature resistant solid corrosion inhibitor manufacturing and using method used in oil pipe and casing pipe. Its raw material preparation weight ratios are as follows: some dibasic acid 20-35%, diethylene triamine 5-15%, chloroacetic acid 5-15%, and sodium dodecyl benzene sulfonate, hexamethenyl tetramine, HPMA, poly epoxy succinic acid, epoxy resin, polyamide resins etc. The manufacturing method includes composing intermediate, preparing solid inhibitor, solidifying, forming, cooling to gain solid inhibitor finished product.

The invention discloses a magnetic targeting carrier capable of carrying genes and drugs, a preparation method and an application thereof. The invention is a carrier which has stability, safety and targeting and has controlled release behavior for non-viral magnetic gene therapy and drug therapy. The carrier material of the invention is characterized in that the carrier material is a bunchy silica mesoporous material with magnetism; the length-diameter ratio is not less than 3; the loading capability is big; the material has a protective effect on loaded genes and carriers and superparamagnetism, is not easy to agglomerate, and can control release speed of genes and drugs in vitro; and the surface thereof is easy to modify various functional groups, thus having wide adaptability. The invention also provides a preparation method of the carrier. When in use, therapeutic short chain DNA, siRNA or drugs enter in holes or are combined with surface modified functional genes by a soaking mode, then reach a targeted tissue by guidance of an applied magnetic field, and release the short chain DNA, siRNA or drugs carried thereby under the action of an alternating magnetic field, thus achieving the purpose of magnetic targeting controlled therapy.

The invention discloses a pollution-free paddy rice planting method. The method comprises the following steps: A, planting milk vetch as green manure in a rice field, and applying a basic manure, wherein 500-800 kg of the basic manure is applied to each mu of the rice field; B, after the rice field is subjected to exposure, performing rotary tillage, ridge separation, irrigation and rice transplanting; C, applying a compound fertilizer to seedlings after the seedlings are inserted; D, grazing 8-15 7-10-day-old ducks to each mu of the rice field after 15-20 days of rice transplanting, evicting the ducks from the rice field after 25-40 days, spraying a biological pesticide, draining for 7-10 days, topdressing 30-100 kg of the compound fertilizer used in the step C to each mu of the rice field, irrigating till the depth of water is 8-10 cm, grazing 5-10 7-10-day-old ducks to each mu of the rice field again, and evicting the ducks from the rice field before 15-20 days of rice mature. According to the pollution-free paddy rice planting method, the yield is high, pollution is avoided, produced rice tastes good, and meanwhile, high-quality duck is obtained.

The invention belongs to the technical field of medicinal preparation and relates to an enteric preparation and sustained or controlled release preparation, in particular to an enteric controlled release micro-granule with budesonide and its preparation method. The invention, which comprises a quick release celphere, a controlled release layer and an enteric layer, takes budesonide as active ingredient of the drug to coordinate with medicinal carrier supplementary materials. After the release level testing, it is proved that the enteric controlled release micro-granule, which adopts different enteric materials, controlled release material and different coating conditions, does not release in stomach but began to release slowly after entering the small intestine with even release level. Therefore, the enteric controlled release micro-granule in the invention can effectively prevent the release in stomach, ensure the slow release in small intestine and the release of drug in the affected section of small incestine, ileocecus and colon.

The invention discloses a doxycycline-hyclate-carried GTR (Guide Tissue Regeneration)/GBR (Guide Bone Regeneration) composite membrane and a preparation method thereof and belongs to the technical field of medicines. The GTR/GBR composite membrane adopts a three-layer structure, wherein the upper surface layer, the lower surface layer and the sandwich layer are all manufactured through sequence electrospinning; the upper surface layer and the lower surface layer are prepared from a natural polymer material and a mixed solution through which the polymer material is synthesized; the sandwich layer is a membrane layer prepared from a doxycycline-hyclate-carried solution through which the polymer material is synthesized. The uniaxial sequence electrospinning method is adopted to prepare the composite membrane adopting the three-layer structure, so that the medicine entrapment efficiency of fibers is improved, the preliminary burst effect of a medicine is reduced/eliminated, and continuously slow release of the medicine is realized. The two surface layers of the three-layer medicine-carried composite membrane can not only serve as porous barriers to control the medicine release rate so as to realize continuously slow release of the medicine but also prevent direct contact between the medicine and tissues to improve the compatibility between the tissues and the membrane so as to be more conducive to tissue repair and regeneration.

The invention discloses a planting method for organic high-yield rice. The method comprises: planting broad beans in a rice field, after harvesting the broad beans, performing green manure dressing and retting, and applying base fertilizer; performing water-controlling harden-seedling on rice seedlings whose seedling age is 15-20 days for 2-3 days; performing rotary tillage, ridge dividing, irrigation on the rice field, and then transplanting rice seedlings; after the rice seedlings survive, dressing a compound fertilizer to promote rice seedling tiller; 13-18 days after rice transplanting, putting newly-hatched ducklings whose day-age is 12-20 in the rice field according to amount of 8-15 per mu, 25-40 days after putting the ducks in the rice field, driving the ducks out of the rice field, spraying biopesticide, performing field draining for 7-10 days, topdressing a nitrogen-phosphorus-potassium composite fertilizer according to amount of 20-50 kg per mu, and then irrigating to 8-10 cm, and driving the ducks in the rice field, 15-20 days before the rice is mature, taking back the ducks, and cutting off water and drying the field. The planting method for organic high-yield rice is high in yield, and obtained rice is good in quality, and high-quality duck meat is obtained.

The invention provides composite antibiotic hydrogel based on controlled release of aminoglycoside antibiotics and ornidazole. The composite antibiotic hydrogel is obtained by crosslinking an oxidizednatural polysaccharide polymer, the aminoglycoside antibiotics and the ornidazole through an acid-sensitive Schiff base bond, wherein the ornidazole is modified by a first-generation polyamidoamine dendrimer with an amino terminal. The Schiff base bond is broken in an acidic environment caused by bacterial infection, so that gel degradation is caused, and the on-demand release of the antibioticsis realized. The composite antibiotic hydrogel is easy to prepare and low in cost. According to the prepared controlled-release composite antibiotic hydrogel, the strength, morphology and degradationof the gel, the release rate of drugs and the like can be controlled based on the content of antibiotics, the composite antibiotic hydrogel has broad-spectrum high-efficiency antibacterial properties,and the bacteriostatic effect is superior to that of various kinds of commercial antibacterial gel on the market. The hydrogel is expected to be prepared into external dressings, ointment preparations, implants, coatings on medical apparatuses and instruments and the like and used for resisting infection caused by Gram-negative bacteria, Gram-positive bacteria, anaerobic bacteria and the like.

The invention discloses netilmicin sulfate lyophiled powder injection and a preparation method of the netilmicin sulfate lyophiled powder injection. Netilmicin sulfate and additives are added with water to be prepared into netilmicin sulfate injectable suspension, and the netilmicin sulfate lyophiled powder injection is obtained through freeze drying, wherein the additives are inclusion moleculesand pH conditioning agents, the inclusion molecules are selected from bletilla striata polysaccharide, beta-cyclodextrin, urea, thiourea, beta-cyclodextrin derivatives, deoxycholic acid and starch, and the pH conditioning agents are selected from sodium carbonate, sodium bicarbonate, ammonia water, sulfuric acid and phosphoric acid. Required auxiliary materials are few, the preparation process issimple, the freeze drying process is particularly screened and optimized, and the netilmicin sulfate lyophiled powder injection and the preparation method has the characteristics that the stability is high, the biological availability is high, the production cost is low, the quality is safe and reliable, and the like.

The invention discloses a preparation process for a sustained-release chlorine dioxide antibacterial film. The preparation process prepares a reaction type chlorine dioxide antibacterial film by using polyvinyl alcohol and polylactic acid as main base materials and compounding a film A and a film B through a wet process, wherein the film A is prepared through the following steps: selecting polyvinyl alcohol as a film-forming base material, preparing a polyvinyl alcohol gel aqueous solution by using a stable chlorine dioxide aqueous solution, then carrying out drying through a casting process so as to form a film, and with glycerol as a plasticizer, adding carboxymethyl cellulose so as to increase hygroscopicity of the film and promote the release of chlorine dioxide; and the film B is prepared through the following steps: selecting the polylactic acid as a film-forming base material, dissolving the polylactic acid with dichloromethane, adding one selected from the group consisting of an activator citric acid or tartaric acid into the obtained solution, adding a plasticizer and an antioxidant, and carrying out casting so as to form a film. The chlorine dioxide antibacterial film prepared by using the preparation process provided by the invention needs water to activate, thereby being able to be used as a packaging material of fruits and vegetables with high water content, wherein the water released by the respiratory action of the fruits and the vegetables activates a chlorine dioxide antibacterial agent, so the water in the package is reduced; meanwhile, the growth of microorganisms is inhibited; and the shelf life of the fruits and the vegetables is prolonged.

The invention discloses Rhizoma coptidis total alkaloids resin complexes, a sustained-release preparation thereof and a preparation method thereof. The Rhizoma coptidis total alkaloids resin complexes comprise Rhizoma coptidis total alkaloids and acidic K plus resin (Amberlite TMIRP88 resin). In 100g of the complexes, the total content of jateorrhizine, coptisine, palmatine and berberine is (67.75 plus/minus 1.26) g and the content of the berberine is (54.87 plus/minus 1.64) g. An assay determination of IR, DSC, X-ray diffraction, and the like, proves that the medical resin complexes are formed by bonding of Rhizoma coptidis lkaloids and cation exchange resin through the ionic bond rather than simple physical adsorption. An orally taken sustained-release preparation thereof is prepared by using the medical resin complexes as raw material and Carbopol 974 PNF as the sustained-release material. An in-vitro dissolving test proves that the sustained-release preparation has a good sustained-release function and can sustainably release for 8h to 24h according to different designs.

The invention relates to an artificial joint prosthesis with an anti-infection function, the artificial joint prosthesis is prepared by the following method: (1) surface treatment of the artificial joint prosthesis: polishing the surface of the artificial joint prosthesis to be smooth, then performing ultrasonic cleaning with acetone, ethanol and deionized water, and drying for later use; (2) implanting or depositing silver ions on the surface of the artificial joint prosthesis: depositing the silver ions on the surface of the artificial joint in a magnetron sputtering manner; (3) deposition of a polydopamine coating: firstly preparing a Tris-HCl buffer solution, adding a dopamine hydrochloride solution into the Tris-HCl buffer solution to complete preparation of a dopamine solution, putting the artificial joint prosthesis containing the silver film layer into the dopamine solution, carrying out a reaction in a dark place, and depositing the polydopamine coating on the surface of the artificial joint containing silver ions; and a photothermal effect is generated through irradiation of a 808nm near-infrared light source, so that silver ions generated through in-vivo release and local high temperature generated by near-infrared light have an excellent synergistic sterilization effect, infection can be reduced, and the anti-infection capability of the artificial joint can be enhanced.

The invention belongs to the field of medicine preparation, and provides a water-soluble medicine framework sustained release tablet. Through auxiliary material combination of a specific ratio, the framework sustained release tablet is prepared by adopting a direct compression method. On the basis of an ordinary polyoxyethylene framework tablet, an adjusting medicine release substance which can have mutual action with unshared electron pairs on ether oxygen bonds of polyoxyethylene and an inorganic salt auxiliary material which can affect the viscosity are added, a lubricant is further added, direct compression is carried out so as to prepare the novel framework sustained release tablet. The medicine can be uniformly released within 24 hours, the defects that the preparation process is complex, the sudden release at the early period and the release at the later period in medicine release are not complete, and the like, are overcome, and not only is the release effect ideal, but also the process is simple, the cost is low, and the industrialized production is facilitated.

The invention provides a biodegradable drug-loaded nanofiber medical bandage for burn department and a preparation method thereof. The medical bandage is of a double-layer structure composed of a surface supporting layer and an inner hydrophobic layer. A common gauze bandage subjected to carboxymethylation modification is used as a main body structure to serve as the surface supporting layer; a coaxial electrostatic spinning method is adopted, the surface supporting layer serves as a receiving layer of coaxial electrostatic spinning, and the inner hydrophobic layer with shell/core structure coaxial nanofibers is constructed on the fiber surface of the common gauze bandage subjected to carboxymethylation modification; in the coaxial nanofiber with the shell/core structure, a shell layer material is a mixture of gelatin and zein, and a core layer material is a mixture of chitosan and active ingredients. The medical bandage has excellent biocompatibility, degradability, hemostatic and antibacterial properties, anti-adhesion performance and drug sustained release performance. The preparation method is simple and controllable, and has huge application value.

The invention belongs to the field of sustained-release drug preparations, and particularly relates to a trimetazidine hydrochloride sustained release tablet taking glyceryl behenate as a framework material and a preparation method of the trimetazidine hydrochloride sustained release tablet. According to the main technical scheme disclosed by the invention, a sustained-release preparation is prepared from trimetazidine hydrochloride as an effective component, only glyceryl behenate as a sustained-release framework material and auxiliary materials such as a small amount of release speed regulator. According to the trimetazidine hydrochloride sustained release tablet provided by the invention, an in vitro release rate experiment shows that the drug release is not affected by the pH environment, compared with commercially available 'vasorel' (trimetazidine dihydrochloride tablet), the trimetazidine hydrochloride sustained release tablet has good similarity (f2 is greater than 65); and the Beagle pharmacokinetic experiment in dogs shows that the trimetazidine hydrochloride sustained release tablet has bioequivalence in comparison with 'vasorel'. One trimetazidine hydrochloride sustained release tablet provided by the invention is taken twice a day, and the trimetazidine hydrochloride sustained release tablet is convenient to take, has good medicine compliance in patients, and is capable of keeping steady state plasma concentration for a long period of time. The preparation method disclosed by the invention is simple and stable in process, and is easily put into volume production.

The invention discloses a compound slow-release fertilizer for wintering southern magnolia. The compound slow-release fertilizer comprises the following raw materials in parts by weight: 80-100 partsof ammonium chloride, 25-35 parts of monopotassium phosphate, 15-25 parts of plant ash, 10-20 parts of precipitated phosphate fertilizer, 65-75 parts of organic fertilizer, 6-12 parts of clay compound, 3-5 parts of bentonite, 2-4 parts of medical stone powder, 0.2-0.4 parts of compound enzyme preparation and 0.2-0.4 parts of compound fermentation preparation. The clay compound is prepared by mixing and grinding attapulgite clay and absolute ethyl alcohol, adding a hydrofluoric acid aqueous solution for placement, filtration and washing, and adding active carbon, alkylphenol ethoxylate and absolute ethyl alcohol for stirring, filtration and washing. The fertilizer can provide nutrition for growth of magnolia liliflora desr, effectively increases growth efficiency and a survival rate of themagnolia liliflora desr, is good in slow release effect, improves a soil structure and can effectively keep normal growth of the magnolia liliflora desr, and a release rate of the fertilizer is effectively adjusted.

The invention discloses an aquaculture water oxygen producer. The aquaculture water oxygen producer is prepared from the following raw materials: vermiculite, a disintegrating agent, sodium citrate, sodium percarbonate, alkyl dimethyl betaine, sunflower plates, boric acid, tetrabutyl titanate, urea and the like. On one hand, solid excreted organic matters such as fish and shrimps in water are degraded and the aquaculture water quality is improved, and on the other hand, the oxygen release speed is controlled via photocatalysis while the disintegrating speed of the oxygen producer in the water is regulated and controlled, long-time and sufficient feeding of the water can be guaranteed effectively, and high economic value is achieved.

The invention discloses a nutrient material for improving soil structure. Raw materials of the nutrient material for improving the soil structure are composed of, in parts by weight, 100-160 parts of river mud, 2-6 parts of ammonium nitrate, 1-5 parts of calcium superphosphate, 2-6 parts of potassium dihydrogen phosphate, 0.1-0.6 part of zinc fulvate, 0.2-0.8 part of EDTA chelated iron, 1-3 parts of zeolite powder, 20-30 parts of fishbone dust, 5-19 parts of decomposed cow dung, 5-12 parts of corn meal, 4-10 parts of limestone powder, 1-6 parts of earthworm cast, 5-10 parts of modified halloysite carbon nano tubes, 4-10 parts of bamboo charcoal, 2-8 parts of medical stones, 1-4 parts of fly ash, and 2-6 parts of quartz sand.