5results about How to "Regulated release rate" patented technology

The invention relates to a preparation method of a sodium alginate composite hydrogel microneedle for treating pathological scars, and belongs to the technical field of hydrogel microneedles, the microneedle takes sodium alginate as a main material, the sodium alginate is methylated to obtain methylacryloylated sodium alginate AlgMA, hollow manganese dioxide nanoparticles loaded with matrix metalloproteinase are added, and the microneedle is prepared by a hydrothermal method. A hydrogel microneedle filling solution is obtained; the preparation method comprises the following steps: transferring the hydrogel microneedle into a PDMS microneedle mold, carrying out negative pressure vacuum bubble removal, drying and concentrating twice in a drying oven, carrying out photopolymerization crosslinking, forming a solid hydrogel microneedle tip, adding a 20% PVA solution, and drying in the drying oven to form the microneedle substrate, and the preparation method is simple, convenient and efficient, has industrial application potential, and is suitable for the scenes of drug delivery, skin care and the like; according to the application of the sodium alginate composite hydrogel microneedle in pathological scar drug delivery, the sodium alginate composite hydrogel microneedle has excellent mechanical strength and biocompatibility, and painless and noninvasive drug delivery can be carried out on the surface of scar skin.

The application provides a groove structure and a medical stent. The groove structure comprises a body, a groove and a drug coating. The groove is located on the body. A part of the outer surface of the body forms a shoulder, and the shoulder is located at at least one side of the opening of the groove. A part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. In this way, a part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. An operator can control the contact area of the drug coating with the vascular tissue by adjusting the drug loading of the shoulder and the thickness of the drug coating in the groove, thereby controlling the release rate of the drug coating.

The present invention discloses a drug sustained-release tablet and a preparation method thereof. The preparation method of the drug sustained-release tablet adopts direct powder compression or dry granulation for preparation, and the preparation process does not include a heating step; the raw materials of the drug sustained-release tablet include a lipid material, a hydrophobic lubricant and a highly soluble drug; wherein the lipid material includes a waxy material, and the particle size D90 of the waxy material is less than 150 μm; and the raw materials do not contain a solvent. In the present invention, no additional solvent is introduced, and no heating is required, and a drug sustained-release tablet of qualified quality can be well prepared, the process is simple, the production efficiency is high, and the active pharmaceutical ingredient in the drug sustained-release tablet is stable.

The invention provides a quercetin-based polyurethane material, a novel metal-ligand coordination cross-linked polyurethane material and a preparation method and application of the quercetin-based polyurethane material and belongs to the technical field of polyurethane materials, and the structural formula of the novel metal-ligand coordination cross-linked polyurethane material is shown in the specification. The preparation method comprises the following steps: adding diisocyanate into a completely molten dihydric alcohol oligomer system, and reacting to obtain an isocyanate-terminated prepolymer; adding a quercetin solution into the prepolymer system, and reacting to obtain a quercetin-based polyurethane solution; and adding a metal ion solution into the quercetin-based polyurethane solution system, and volatilizing the solvent after the reaction to obtain the novel metal-ligand coordination cross-linked polyurethane material. According to the invention, oligomer dihydric alcohol is taken as a soft segment, quercetin is taken as a chain extender, and a polyurethane material containing quercetin in a main chain and a metal-ligand coordinated cross-linked polyurethane material are synthesized by a one-pot method; wherein the metal ions are used as cross-linking points to be connected with a polyurethane main chain, so that a more flexible network structure is formed.

The present invention discloses a sterilization iodophor compound composition and a processing technology thereof, and relates to the technical field of sterilization, xanthan gum is added into deionized water, stirring is performed until complete dissolution, cooling is performed, glycerol and an amino-polyethylene glycol-polyacrylic acid block copolymer are added, stirring is performed until complete dissolution, povidone iodine is added, stirring is performed until complete dissolution, and the sterilization iodophor compound composition is obtained. And adding the microcapsule solution, adding deionized water, stirring, keeping out of light, standing and filtering to obtain the iodophor compound composition for sterilization. The povidone iodine can oxidize and destroy bacterial protein and nucleic acid by providing free iodine, so that a broad-spectrum bactericidal effect is achieved; thymol and eugenol destroy bacterial cell membranes and cell walls and inhibit key enzyme activity so as to realize a bactericidal effect; tannic acid is combined with protein to form a compound on a cell membrane to destroy the membrane function of the cell membrane; through the synergistic effect of the three components, the sterilization effect of the iodophor compound composition for sterilization is improved.