Pearl powder artificial bone supporting material with multi-stage micro-nano structure and technique for producing the same

Abstract

The invention relates to a novel biological scaffold material for bone repair and a preparation method thereof. PLGA and PLA with a mass ratio of 1: 1-10: 1 are dissolved into chloroform, dimethyl sulfoxide, 1, 4-dioxane or a mixed liquid of the 1, 4-dioxane and ultrapure water, and then pearl powder which is subjected to partial or complete deproteinization treatment is added into the obtained product according to the proportion of the PLGA / a PLA mixture to the pearl powder (mass ratio) is 1: 1-10: 1 to obtain forming slurry. A three-dimensional scaffold with high porosity and connectivity rate is designed through a 3D software, and then a low-temperature rapid forming system is utilized to ensure that the three-dimensional scaffold is formed to obtain a scaffold with a microporous structure. An artificial bone biological scaffold material prepared by the method has a three-dimensional scaffold structure that a macroscopic structure has aperture channels with diameters of between 100 and 500mu m and a microstructure has micropores with diameters of between 10 and 20mu m, wherein micron pearl powder is dispersedly distributed on walls of the micropores. The porosity is between 60 and 90 percent, and a macroporous structure is perforated in three directions of X axis, Y axis and Z axis, and has 100 percent of connectivity.

Description

technical field

[0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a new bio-scaffold material for bone repair and a preparation method thereof. Background of the invention

[0002] At present, there is an urgent and huge market demand for artificial bone tissue with good physiological functions and no rejection for bone defect repair in the world. In the field of artificial bone manufacturing, foreign research institutions and enterprises have invested a lot of resources in recent years and achieved a series of research results. Some artificial bone materials for defect repair have begun to enter clinical applications. At the same time, there are still many problems to be solved in the core issues of bone scaffold materials such as biocompatibility, osteoinductivity, porosity, and mechanical strength.

[0003] Pearl powder is an ideal natural bone-forming material, which has the characteristics of biocompatibility and ...

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