154 results about "Porous scaffold" patented technology

The invention relates to the technical field of biomedical materials, in particular to an oral repair film and a preparation method and application thereof. The oral repair membrane comprises an electrostatic spinning membrane with the porosity of 30%-40%, and polymer microspheres, recombinant humanized collagen and mussel mucoprotein which are attached to the electrostatic spinning membrane, wherein the particle size of the polymer microspheres is 25 [mu] m-50 [mu] m. According to the oral cavity repairing film provided by the invention, by combining a polymer electrostatic spinning technology, a shearing and emulsifying microsphere preparation technology, a microsphere slow release technology and a three-dimensional porous bracket freeze-drying technology, the problems that a repairing film in the marketed or published technology is small in contact area and needs to be sewn are solved; the tissue regeneration can be efficiently stimulated, the treatment time is shortened, the treatment effect is improved, suturing is not needed, and clinical operation is facilitated.

Method for generating a porous injectable scaffold that includes providing a liquid composition of 2 phases at a temperature below 25° C., of Newtonian behavior, where the composition comprises:a liquid dispersant phase at room temperature formed by a gelatin with a low melting point, less than 15° C., functionalized with methacryloyl or methacrylamide groups; and a photoinitiator;and a dispersed phase, of microdroplets or beads in solid state, of a gelatin solution with a melting point greater than 25° C.;initiating the polymerization of the dispersing phase by light radiation; raising the temperature to 35-40° C. and allowing melting of the dispersed phase; and obtaining a porous scaffold.The formed porous scaffold and its use as a biological support for tissue regeneration / generation; as a biological matrix as a support for cells, for cell invasion; as an acellular biological matrix, a biological matrix as a mechanical support and / or a biological matrix for active components.

The invention provides a high-energy-absorption impact-resistant aluminum-based composite material, the aluminum-based composite material comprises a ceramic porous scaffold and an aluminum alloy base material, the ceramic porous scaffold is formed by compounding porous aerogel and an S-type electrostatic spinning membrane, and the aluminum alloy base material comprises the following components: 0.2-0.8 wt% of Cu, 0.2-0.8 wt% of Ni, 0.2-0.8 wt% of Ti, 0.2-0.8 wt% of Ti, and the balance of Al. The content of Mg is 0.6 to 1.2 weight percent; the content of Zn is 0.2 to 0.5 wt%; the content of Mn is 0.1 to 0.2 wt%; the content of Y is 0.05 to 0.25 weight percent; and the balance of Al. According to the invention, the ceramic skeleton is used as a reinforcing phase, and pores of the ceramic skeleton are filled with the aluminum alloy through a molten aluminum alloy pressure infiltration process, so that a novel composite structure is formed. According to the structure, the characteristics of high strength and high energy absorption of the ceramic material are brought into full play, and the brittleness of the ceramic is effectively relieved through the plastic deformation capacity of the aluminum alloy, so that the overall shock resistance and the energy absorption capacity of the material are remarkably improved.

A biologic matrix comprises a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized, suspension-dried mammalian organ or tissue. The scaffold features a porous structure with a plurality of interconnected pores originating from one or more of its outer surfaces. The pores are created by forcing a gas through the vascular pathways of the mammalian organ or tissue while it is in a suspended position. This enables the gas to inflate the vascular pathways in all directions without restriction. The porous configuration substantially enhances the scaffold's effective surface area, making it at least 10 times greater than that of a non-porous scaffold having equivalent outer dimensions. In certain embodiments, the surface area considering the interconnected pores can be 15 times larger or more than the non-porous scaffold of equivalent outer dimensions.

The present invention provides a method for producing spheroids and cellular by-products of spheroids, such as extracellular vesicles. The method comprises providing a bioreactor having a cavity for culturing cells; inserting a cell into the cavity to form a spheroid; and perfusing a cell culture medium through the cavity to culture the spheroid. A porous scaffold may be soluble or insoluble, and the cells are inoculated into pores of the porous scaffold, where the cells aggregate in the pores of the porous scaffold to form spheroids. The bioreactor is continuously perfused for large scale spheroid production and enables collection of spheroids and / or extracellular vesicles or other components from cell secretory groups.

The invention belongs to the field of cell biology, and particularly relates to a preparation method and application of an extracellular matrix of cell-engineered human collagen. The preparation method comprises the following steps: S1, culturing human induced pluripotent stem cells or a cell culture comprising the human induced pluripotent stem cells, and directly inducing differentiation to obtain induced mesenchymal stem cells or a cell culture comprising the induced mesenchymal stem cells; and S2, carrying out 3D culture on the induced mesenchymal stem cells through a 3D porous scaffold carrier. The extracellular matrix prepared by the preparation method provided by the invention is rich in collagen, so that the mesenchymal stem cells can be better promoted to be differentiated into osteoblasts, and meanwhile, a new thought is provided for the preparation of the collagen.

The present disclosure relates to methods of treating, preventing, or modulating diabetes in a patient in need thereof using a device for transplanting cells into a host body, specifically a method of treating diabetes in a patient in need thereof, comprising: implanting a device in the patient, wherein the device comprises: a porous scaffold comprising an immunologically compatible polymer mesh forming the walls of at least one chamber, an opening at either or both of a proximal end and a distal end of the chamber, at least one removable, non-porous plug configured to be positioned within the lumen of the at least one chamber, maintaining the device in the patient's body until the device is infiltrated with vascular and connective tissues; and infusing the chamber with cells, wherein at least some of the cells express insulin

The invention belongs to the technical field of implant materials, and discloses a porous titanium-based implant material surface calcium-phosphorus coating and a preparation method thereof. According to the method, a porous titanium-based implant material is used as a cathode, an annular platinum electrode is used as an anode, the cathode is located in the center of the annular electrode, a solution containing calcium and phosphorus is used as an electrolyte, biomimetic mineralization is carried out under the condition of pulse micro-potential, and the calcium-phosphorus coating is formed on the surface of the porous titanium-based implant material. According to the method, the biomimetic mineralization process of the surface of the beam structure in the porous titanium-based material is regulated and controlled by adopting the annular electrode and the weak electric field, migration of ions and ion groups in the porous scaffold is improved by adjusting the current of the annular electrode and combining the biomimetic mineralization process, and the porous titanium-based implant material uniformly covered with the calcium-phosphorus coating is obtained. The method is simple, and uniform covering of the calcium-phosphorus coating of the porous titanium-based implant material is achieved.

A method for preparing a magnesium alloy tissue engineering scaffold with a smooth inner surface by laser powder bed fusion (LPBF) is provided. The method includes: step S1: scanning a porous scaffold, and selecting the densest filling scan parameters, where the scanning includes a single-pass contour scan and a single-pass filling scan; step S2: optimizing a contour scan strategy according to the densest filling scan parameters; step S3: acquiring a corresponding melt pool dimension, and adjusting a spot compensation value based on the optimized contour scan strategy; and step S4: preparing a magnesium alloy tissue engineering scaffold based on the contour scan strategy and the adjusted spot compensation value. The method eliminates powder adhesion and sagging defects inside the complex porous structure that severely affect inner surface roughness and scaffold performance, thereby the pore connection, fatigue and corrosion resistance will be improved greatly.

The invention belongs to the technical field of biomedical materials, and particularly relates to an intelligent degradable three-dimensional porous scaffold with piezoelectric activity and a preparation method and application thereof. According to the method, the piezoelectric white calcium phosphate and the degradable metal material which are in a proper proportion are subjected to ultrasonic mixing, so that the piezoelectric white calcium phosphate is uniformly adsorbed on the surface of the degradable metal material in a physical adsorption mode, and then the composite powder obtained through mixing is subjected to 3D printing; the three-dimensional porous scaffold which is excellent in mechanical property, good in biological safety, sensitive in piezoelectric responsiveness and capable of adaptively regulating and controlling the degradation rate is prepared, a good supporting effect is provided for a critical bone defect part, meanwhile, the stress condition of the critical bone defect part is sensitively sensed, micro-current is generated in the three-dimensional porous scaffold through the stress effect, and the three-dimensional bone defect part is obtained. According to the invention, degradation of the degradable metal material and generation of new bones are promoted, and the degradation rate is adaptively adjusted according to the stress, so that the degradation rate is matched with the bone remodeling rate, and bone remodeling is effectively promoted.

The invention discloses a preparation method and application of a citric acid-based polymer stable amorphous calcium phosphate porous scaffold for bone defect repair. The preparation method of the citric acid-based polymer stable amorphous calcium phosphate porous scaffold comprises the following steps: carrying out a polymerization reaction on an amorphous calcium phosphate precursor and citric acid-based poly (1, 8-octylene glycol-citrate) at 80 DEG C for 2-3 days or carrying out a polymerization reaction at 80 DEG C for 3 days and then carrying out a reaction at 120 DEG C for 1 day to obtain the porous scaffold with stable amorphous calcium phosphate characteristics. According to the present invention, the uniform dispersion and the effective and stable combination of the amorphous calcium phosphate precursor particles in the citric acid-based poly (1, 8-octylene glycol-citrate) matrix are achieved, and the biomimetic mineralized bone repair scaffold with characteristics of porous structure, high mechanical strength, controllable degradability and excellent osteogenic activity is successfully constructed. According to the stent, the technical problem of insufficient stability in application of amorphous calcium phosphate is remarkably solved, the osteogenic activity of the material is improved, and the stent has a great application prospect in the field of clinical bone defect repair.

An apparatus includes a porous scaffold characterized by a scaffold refractive index. The optically written optical component is embedded in the porous scaffold. The coating forms a surface of the porous scaffold. The coating includes a surface and a transition region. The surface is characterized by a surface refractive index. The transition region features a refractive index gradient that transitions between the surface refractive index and the stent refractive index.

The invention provides a shape memory nano short fiber stent with self-adaptive capacity and preparation and application thereof, and belongs to the technical field of tissue engineering materials. The preparation method comprises the following steps: firstly, preparing flexible polylactic acid-fullerol composite nanofibers containing uniformly dispersed fullerol nanocrystals by utilizing an electrospinning technology, then dividing the flexible polylactic acid-fullerol composite nanofibers into short fibers by virtue of homogenization and freeze-drying processes, and assembling the short fibers into a three-dimensional porous scaffold by taking chitosan as an adhesive. The porous scaffold material disclosed by the invention has excellent biological characteristics and a water-triggered shape memory effect, and due to the fact that chitosan has excellent antioxidant activity and inherent bone induction characteristics, the nanofiber scaffold with the controllable and recoverable shape developed by the invention is expected to effectively promote osteoporotic bone healing.

The invention discloses a mechanically controllable composite membrane material, which comprises a three-dimensional porous scaffold composed of bacterial cellulose, and bioactive ceramic nanoparticles are uniformly dispersed in and on the surface of the three-dimensional porous scaffold; the bioactive ceramic nanoparticles are one or more of tricalcium phosphate, bioactive glass, calcium silicate and hydroxyapatite. According to the invention, the bioactive ceramic nanoparticles are uniformly loaded inside and on the surface of the three-dimensional porous scaffold formed by bacterial cellulose, and the composite membrane material can be endowed with a unique biological function by adjusting the types of the bioactive ceramic nanoparticles. The composite membrane material prepared by an in-situ, ectopic or chemical deposition method and the like can realize synergy and balance of mechanical properties and biological functions, and the structural design of the composite membrane material provides necessary mechanical support and also gives consideration to flexible fit with fragile nervous tissues, so that the composite membrane material has a wide application prospect in the field of neurosurgery.

The invention discloses a preparation method and application of a functional degradable soybean oil-based bionic porous composite bone scaffold. The method comprises the following steps: taking epoxidized soybean oil acrylate as a bio-based base material, compounding isobornyl methacrylate to improve the defects of high viscosity and low photosensitivity of the bio-based base material, adding a photoinitiator containing ethyl 2, 4, 6-trimethylbenzoyl phenyl phosphonate and phenyl bis (2, 4, 6-trimethylbenzoyl) phosphine oxide, compounding, and carrying out aging treatment to obtain base resin; mixing calcium lignosulphonate into the base resin to prepare composite photosensitive resin, and printing a triple-period extremely-small curved surface structure through a digital light processing technology and a 3D printing technology to finally obtain the functional degradable soybean oil-based bionic porous scaffold. The scaffold has calcium lignosulphonate-mediated controllable photo-thermal response behaviors of near-infrared light illumination regulation and bone scaffold component dependence under the condition of simulating the in-vivo environment of a human body, so that a controllable photo-thermal response-mediated remote shape memory function is realized, and meanwhile, a mild, safe and controllable photo-thermal curative effect can also be realized. Besides, calcium lignosulphonate promotes degradation of the composite scaffold by preferentially dissolving and generating a microporous structure on the surface of a matrix while improving the hydrophilic performance of the scaffold, and continuously releases calcium ions, so that the scaffold shows enhanced biomineralization ability and promotes cell proliferation and osteogenic differentiation. The research provides a solution with potential for the soybean oil-based biological photosensitive material in the digital light processing preparation technology and the multi-functional application of the bionic porous bone scaffold so as to deal with complex and irregular bone defects.

Three dimensional (3D) bioreactors for the large-scale expansion of immune cells and methods of use thereof are provided.SOLUTION: 3D bioreactors comprise at least one packed bed chamber comprising at least one microporous scaffold, at least one microporous scaffold coated with one or more extracellular matrix proteins (ECMs), at least one vessel comprising a fluidic media, wherein the fluidic media is configured to flow through the packed bed chamber having the at least one microporous coated scaffold, and at least one population of immune cells suspended in the fluidic media. The at least one porous scaffold coated with ECM forms an anchoring niche with low shear forces that mimics the natural growth environment of immune cells. This allows for large scale expansion of the immune cell population flowing through the coated porous scaffold.SELECTED DRAWING: FIG. 2 (1)

This application relates to the technical field of medical dressings, specifically to a preparation method of a dressing with a repair function, including: mixing citric acid-modified fucoidan and chitosan, adding water, heating and then performing ultrasonic oscillation, adding a crosslinking agent, heating while stirring to obtain a stock solution; mixing calendula extract, centella asiatica extract, dandelion extract, green tea extract, and honey, adding them to a high-speed disperser, adding water, after high-speed dispersion, adding them to the stock solution, continuing to stir, filtering, evaporating, standing to remove bubbles to obtain a precursor solution; soaking a porous scaffold in the precursor solution, allowing the precursor solution to penetrate into the pores of the porous scaffold through capillary action, and performing irradiation crosslinking and curing to obtain a dressing with a repair function. By selecting specific components for combination and using a specific preparation method, the prepared dressing with a repair function has good moisture retention, antibacterial properties, and mechanical strength while maintaining good wound repair function.

Biologic matrices designed to facilitate wound healing and related methods are disclosed. A matrix comprises a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized mammalian organ or tissue. The scaffold features a porous structure with a plurality of interconnected pores originating from one or more outer surfaces, which are defined by intact vascular pathways of the perfusion decellularized mammalian organ or tissue. The porous configuration substantially enhances the scaffold's effective surface area, making it at least 5 times greater than that of a non-porous scaffold having equivalent outer dimensions. In certain embodiments, the surface area considering the interconnected pores can be 10 times larger, 15 times larger, or more than the non-porous scaffold of equivalent outer dimensions. The density of the scaffold can range from 2 milligrams per cubic centimeter to 20 milligrams per cubic centimeter, inclusive, further optimizing the matrix's performance for wound healing applications.

The present invention relates to systems and methods for large scale expansion and activation of immune cells. Three-dimensional (3D) bioreactors for large scale expansion of immune cells and methods of using the same are disclosed. The 3D bioreactor comprises: at least one packed bed chamber comprising at least one porous scaffold; at least one porous scaffold coated with one or more extracellular matrix proteins (ECMs); at least one container containing a fluid medium configured to flow through the packed bed chamber having at least one porous coated scaffold; and at least one population of immune cells suspended in a fluid medium wherein the at least one porous scaffold coated with the ECM creates a fixed niche with low shear force that mimics the natural growth environment of the immune cells and allows large scale expansion of the population of immune cells flowing through the coated porous scaffold.

A mycelium-based composite is provided. The mycelium-based composite comprises a 3D- printed wood-polylactic acid porous scaffold, a nutrient-rich layer coated onto inner and outer surfaces of the 3D-printed wood-polylactic acid porous scaffold, and mycelium of a fungus grown on the inner and outer surfaces of the coated 3D-printed wood-polylactic acid porous scaffold, forming a network of hyphae covering the inner and outer surfaces of the coated 3D- printed wood-polylactic acid porous scaffold, wherein the 3D-printed wood-polylactic acid porous scaffold has a porosity ranging from 50% to 90%. A method of producing the mycelium- based composite is also provided.

Biologic matrices designed to facilitate wound healing and related methods are disclosed. A matrix comprises a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized mammalian organ or tissue. The scaffold features a porous structure with a plurality of interconnected pores originating from one or more outer surfaces, which are defined by intact vascular pathways of the perfusion decellularized mammalian organ or tissue. The porous configuration substantially enhances the scaffold's effective surface area, making it at least 5 times greater than that of a non-porous scaffold having equivalent outer dimensions. In certain embodiments, the surface area considering the interconnected pores can be 10 times larger, 15 times larger, or more than the non-porous scaffold of equivalent outer dimensions. The density of the scaffold can range from 2 milligrams per cubic centimeter to 20 milligrams per cubic centimeter, inclusive, further optimizing the matrix's performance for wound healing applications.

The invention provides a silk nanofiber porous scaffold and a preparation method thereof, and belongs to the field of polymer nanofiber scaffold preparation.The preparation method comprises the steps that silk nanofibers and water are evenly mixed to obtain suspension liquid, then a cross-linking agent is added into the suspension liquid, the mixture is evenly stirred to obtain a mixed solution, and the mixed solution is dried to obtain the silk nanofiber porous scaffold. Placing the mixed solution in an environment of-20 DEG C to-4 DEG C for constant-temperature freezing treatment for 14-21 days so as to improve the efficiency of the cross-linking reaction and form a topological nanostructure in the scaffold by utilizing the freezing concentration effect of ice crystals on the nanofibers, and finally unfreezing to obtain the silk nanofiber porous scaffold with high porosity. The prepared silk nanofiber porous scaffold has good water stability, and the dissolution loss rate is lower than 20% when the silk nanofiber porous scaffold is soaked in deionized water at 37 DEG C for 24 h.

This invention relates to the field of biomedical materials, and discloses a biomimetic piezoelectric composite membrane, its preparation method, and its application. The biomimetic piezoelectric composite membrane comprises a dense layer and a porous layer. The dense layer contains a first L-polylactic acid and a first D-polylactic acid, while the porous layer contains a second L-polylactic acid, a second D-polylactic acid, and hydroxyapatite. This invention employs a stepwise continuous electrospinning technique to obtain a biomimetic piezoelectric composite membrane with an integrated dense-porous-porous layer structure. The dense layer prevents soft tissue ingrowth into bone defect areas, while the porous layer acts as a porous scaffold, supporting and guiding new bone growth. Simultaneously, it generates electrical signals in response to mechanical stress, promoting osteogenic differentiation. Furthermore, the porous layer is composited with nano-hydroxyapatite, providing essential calcium and phosphorus elements for osteogenic formation. This synergistic effect enhances alveolar bone regeneration and repair capabilities from multiple perspectives, including electrical, chemical, and topological aspects.

The invention discloses an expandable self-adaptive bionic tissue repair nail. The expandable self-adaptive bionic tissue repair nail comprises a nail cap and a nail body which are made of biodegradable materials, the nail cap is a double-layer film layer, and the layer, away from the nail body, of the nail cap is a smooth compact layer. The layer, close to the nail body, of the nail cap is a porous support layer, and the surface of the porous support layer is integrated with a combining mechanism tightly attached to the tissue surface. The nail body is of a hollow net-shaped structure, and the inner cavity of the nail body is filled with swellable and biodegradable porous hydrogel; the nail body can be in a compressed and folded compact state in a dehydration state and is expanded and unfolded after encountering water; drugs are loaded in the porous hydrogel. Before implantation, the repair nail is in a dehydrated slender state; after implantation, the internal hydrogel swells when encountering liquid, an irregular fistula channel is filled with the net-shaped structure in a self-adaptive mode, meanwhile, an inner opening is sealed by the nail cap, physical bacteria blocking is achieved, and the nail cap serves as a regeneration support to actively promote repair. The device can be implanted in a minimally invasive mode, can expand in a self-adaptive mode after operation so as to be tightly attached to tissue, and meanwhile has the anti-infection function and the active repair promoting function.

The invention discloses a porous scaffold SLM preparation method and device based on machine learning, and belongs to the technical field of additive manufacturing. The method comprises the following steps: firstly, designing a composite lattice porous structure consisting of inner-layer simple cubic cells and outer-layer body-centered cubic cells, wherein the inner-layer simple cubic cells and the outer-layer body-centered cubic cells are directly connected through nodes; then, a Latin hypercube sampling design test scheme is adopted, and initial small sample data of the selective laser melting process are obtained; then, a regression synthesis minority class oversampling technology is introduced to carry out enhancement processing on the data set; on the basis, establishing a kernel extreme learning machine prediction model optimized by a swarm intelligence algorithm; and finally, reversely solving optimal process parameters based on the target performance and completing preparation. Through the composite structure design, the stress shielding effect is effectively relieved, the problems of high experiment cost, less sample data and low prediction precision in traditional process optimization are solved, and efficient and accurate customized manufacturing of the high-performance medical CoCrMo implant is achieved.

The application claims a preparation method of a ceramic / polymer continuous gradient porous scaffold, and belongs to the technical field of biological tissue engineering bone scaffold. The porous scaffold structure adopts a three-period minimal surface (TPMS) design, and the scaffold structure and volume fraction are controllable. The continuous gradient material adopts a mixed slurry of different volume fractions of hydroxyapatite powder and photosensitive PLA resin as the material, and a gradient polylactic acid layer containing 0% to 30% of nano-hydroxyapatite is sequentially arranged from inside to outside. The high volume fraction of HA / PLA on the outside promotes cell adhesion and improves the bone ingrowth ability. The pure PLA scaffold is prepared by a 3D printing stereolithography forming method, the scaffold surface is activated by using a plasma cleaning process, the slurry with the ceramic material composition on the outer layer is attached to the scaffold surface by using a solution immersion method, the excess slurry in the pores is removed by using a centrifugal device, and ultraviolet light (wavelength range 360-410 nm) is used for irradiation and curing. The application uses a continuous gradient to overcome the shortcoming of the sharp change of the performance of the traditional composite material at the material interface, which leads to stratification.

The present invention provides methods and systems for enhanced production and / or secretion of extracellular vesicles from at least one three-dimensional porous scaffold having a population of stem cells cultured thereon, utilizing various shear stress conditions on a variety of stem cells.

This invention discloses a biomimetic corncob scaffold with piezoelectric, antibacterial, osteogenic, and healing-promoting functions, comprising: extraction of corncob cellulose nanofibers (CNF); preparation of 3D printing ink; 3D printing of a porous scaffold; loading of antimicrobial peptides and BMP-2 onto a GelMA+PAAM composite hydrogel; and composite preparation of the scaffold and hydrogel. Under external stimulation, the scaffold generates a microcurrent / surface charge, directly disrupting bacterial cell membranes; it avoids drug release and resistance issues, employing a physical mechanism of action with a sustainable response. The microcurrent / electric field generated by the piezoelectric effect simulates the bioelectric environment of natural bone, directly stimulating osteoblast proliferation and differentiation, and promoting mineralization; it mimics the natural anisotropic porous structure of the corncob, facilitating nutrient transport and cell migration; the piezoelectric material itself provides both antibacterial and osteogenic functions, achieving synergistic and unified mechanisms; it is suitable for harsh environments, biodegradable, and has flexible activation methods.

The application discloses a piezoelectric porous scaffold with high efficient osteogenesis and a preparation method thereof. The piezoelectric porous scaffold is obtained by mixing a biological component and a piezoelectric component through an adhesive, sintering and then performing polarization treatment. The piezoelectric porous scaffold can efficiently load and adsorb bioactive protein factors, realizes effective release of the protein, and has piezoelectric performance and osteogenesis activity. Under the multiple effects of the piezoelectric effect, the porous structure and the bioactivity of the protein of the scaffold, the piezoelectric porous scaffold can quickly start early response of bone marrow stromal cells in a synergistic manner, and then promote cell adhesion, proliferation and osteogenic differentiation. The piezoelectric porous scaffold has important significance for efficient and rapid repair of large bone defects, bone nonunion and other bone defects.

The invention is applicable to the technical field of biomedical materials, and provides a coating-modified high-molecular polymer porous scaffold and a preparation method and application thereof, a porous polycaprolactone scaffold with high hydrophilicity is prepared by combining 3D printing with a pore-forming agent and a surface etching technology, and the porous polycaprolactone scaffold with high hydrophilicity is applied to the field of biomedical materials. On the basis, hydrogen bonds are formed by abundant phenolic hydroxyl groups of the tannic acid and carbonyl groups on the surface of the stent, uniform adsorption of the tannic acid is achieved, then the residual phenolic hydroxyl groups of the tannic acid are coordinated with copper ions, and a tannic acid / copper uniform coating is constructed on the surface of the stent; finally, the coating-modified polycaprolactone hydrophilic scaffold which is good in mechanical property and has pH-driven antibacterial and osteogenesis-promoting functions is obtained. The scaffold can be applied to the biomedical field of bone defect repair and the like under the condition of bacterial infection, and the problems that a critical bone defect area is delayed and not healed due to bacterial infection, a drug cannot be retained for a long time due to body fluid flushing, and a high-porosity scaffold is insufficient in mechanical performance, too slow in degradation and the like are effectively solved.