257 results about "Porous scaffold" patented technology

The invention relates to a preparation method of a corrosion-resistant radial gradient porous bionic bone scaffold, and belongs to the technical field of medical machinery. According to the method, firstly, the offset C is redesigned according to the relation between a Gyandroid unit cell mathematical formula S (x, y, z) and the offset C, so that the mathematical formula is improved, and the mathematical formula is suitable for the radial gradient porous scaffold. An improved mathematical formula is adopted, a radial gradient porous cuboid model is generated by utilizing a Python script, and a cylindrical radial gradient porous model is obtained through Boolean intersection operation. Then, the model is subjected to smoothing and repairing treatment, and an initial radial gradient porous scaffold is prepared through a selective laser melting (SLM) forming technology; finally, through sand blasting treatment, the finished radial gradient porous bionic bone scaffold is obtained. The uniform porous scaffold has higher corrosion resistance, longer service life and larger specific surface area, is more beneficial to transmission, survival and attachment of bone cells, and has better performance compared with a traditional uniform porous scaffold.

The invention relates to a medical titanium-zinc alloy and a preparation method and application thereof.The medical titanium-zinc alloy comprises a porous pure titanium support and a pure zinc block, and the interior of the porous pure titanium support is of a three-dimensional intercommunication structure; and the pure zinc blocks are filled into gaps of the porous pure titanium bracket in a metal infiltration manner to form the titanium-zinc alloy material. According to the invention, through 3D printing of the pure titanium porous scaffold, the designed intraosseous fixation device promotes the osteogenesis performance in a living body by utilizing the biological activity characteristic of pure zinc metal; meanwhile, the pore diameter of the pure titanium porous scaffold is adjustable, so that the mechanical properties of different medical materials can be met. In addition, in the implanting process, the growth speed of bones can be better matched with the degradation speed of zinc; and finally, after implantation, along with continuous degradation of a zinc-containing phase in the material in an in-vivo environment, formation of a new bone is gradually induced, the new bone grows into a porous structure, and finally a titanium-bone interlocking structure is formed, so that the bonding strength between a bone tissue and an implant is improved.

The present invention relates to the field of biomedical materials, and specifically to a three-layer composite structure collagen-based artificial skin and a preparation method thereof. The artificial skin comprises a three-layer structure, which is respectively a silicone membrane layer-collagen membrane layer-collagen sponge layer from top to bottom, wherein the thickness of the silicone membrane layer is 0.3-1 mm, the thickness of the collagen membrane layer is 0.4-10 μm, the thickness of the collagen sponge layer is 1.5-5 mm, and the total thickness is 1.8-7 mm. The main components of the porous scaffold layer of the artificial skin material are yak collagen and chondroitin sulfate, which are obtained by gradient temperature rise freeze-drying and double cross-linking treatment. The artificial skin not only has good mechanical strength, swelling performance and anti-enzymatic performance, but also has good biological activity and full-thickness skin injury wound repair effect, and has broad application prospects in the medical field.

The present invention discloses a personalized customization of cell-cultured meat based on a porous scaffold material and a production method thereof. The method adopts a material suitable for cell growth and safe and edible, prepares a porous scaffold material with a suitable pore structure based on freeze-drying, and realizes personalized customization of cell-cultured meat by adjusting the cell inoculation parameters. The porous scaffold material constructed by the present invention has good biocompatibility and mechanical properties. Its high porosity, connectivity and suitable pore size structure are suitable for the intercellular information transmission and sufficient exchange of nutrients during cell culture, which is beneficial to the fate processes such as cell growth, proliferation, differentiation and maturation. In addition, the edible qualities such as texture, taste and nutritional value of cell-cultured meat can be improved by inoculating different types of cells and changing the cell inoculation ratio, thereby realizing personalized customization of cell-cultured meat. The porous scaffold material provided by the present invention has important guiding significance for the personalized development of the cell-cultured meat production industry.

The invention relates to the field of bioengineering, in particular to a three-dimensional porous scaffold and sustained-release gel system for alveolar regeneration, which is composed of a three-dimensional porous hydrogel scaffold and temperature-sensitive hydrogel loaded with FGF-7. The three-dimensional porous hydrogel scaffold is prepared from hydroxyethyl methylacrylate-sodium alginate-gelatin frozen gel, and the temperature-sensitive hydrogel loaded with the FGF-7 is chitosan / beta-glycerophosphoric acid / gelatin temperature-sensitive hydrogel loaded with the FGF-7. The invention constructs an effective pulmonary alveolar regeneration promoting system, which not only can promote the repair of damaged pulmonary alveoli and improve the life quality of patients, but also provides new strategies and hopes for the treatment of lung diseases, and has wide clinical transformation prospects.

The invention discloses a light-driven / temperature-driven double-trigger shape memory antibacterial and anti-tumor bone scaffold and a fused deposition modeling (FDM) preparation method thereof, and is characterized in that polylactic acid (PLA) is used as a matrix, and polyethylene glycol (PEG) and nano magnesium hydroxide (Mg (OH) 2) / copper oxide (CuO) are uniformly dispersed through an organic solvent blending method; a composite wire is prepared through the processes of drying and film forming, crushing and granulation and screw extrusion, and finally, the integrated molding of the three-dimensional porous scaffold is realized through an FDM (fused deposition modeling) process. According to the stent, temperature and near-infrared light double-triggered shape memory is achieved through cooperation of glass transition regulation and control of PLA-PEG and the photothermal effect of the nano metal oxide particles. Nano Mg (OH) 2 / CuO endows the scaffold with multi-mode antibacterial and anti-tumor functions: 1) Mg < 2 + > / Cu < 2 + > releases and destroys microbial membrane potential; according to the stent, the limitation of shape fixation of a traditional implant is broken through, shape self-adaption can be triggered through light / heat stimulation, irregular bone defects can be accurately attached, the risk of a secondary operation is avoided, and the stent has remarkable advantages in minimally invasive orthopedic repair.

The invention discloses a 3D printing PCL / nHA combined bionic glycopeptide hydrogel scaffold for infected bone defect substitution and a preparation method thereof, and belongs to the field of biomedical materials. The scaffold comprises a 3D printed PCL / nHA porous scaffold, the 3D printed PCL / nHA porous scaffold is provided with three-dimensional interconnected micro-channels, the mass percentage of nHA is 10-30wt%, the scaffold is further filled with a bionic glycopeptide hydrogel layer formed by mixing methylacryloylated gelatin, aldehyde bletilla striata polysaccharide, antibacterial peptide and a photoinitiator according to the ratio of 10: 4: 2: 1 and carrying out ultraviolet irradiation polymerization, phenyl lithium phosphate is adopted as the photoinitiator, and the bionic glycopeptide hydrogel layer is a bionic glycopeptide hydrogel layer. And 3D printing process parameters are accurately controlled. The preparation method comprises the steps of PCL / nHA porous scaffold preparation, pretreatment, finished product treatment, bionic glycopeptide hydrogel solution preparation, filling polymerization and the like. The scaffold disclosed by the invention integrates excellent mechanical properties, biocompatibility, antibacterial and anti-inflammatory capabilities and strong bone induction biological activity, provides an ideal material for repairing infected bone defects, and effectively overcomes many defects of a traditional skull repairing material.

The invention discloses a design method of a bionic bone scaffold based on a TPMS (Tire Pressure Monitor System), and belongs to the technical field of bionic bone scaffolds. According to the method, on the basis of a G unit formula and a D unit formula, a bias function is adjusted to generate a G gradient unit CAD model and a D homogeneous unit CAD model; fusing the CAD model of the G gradient unit and the CAD model of the D homogeneous unit by using a fusion function to generate a GD radial fusion CAD model, and adjusting an offset function of the G gradient unit by adopting an interpolation method to enable the GD radial fusion CAD model to reach a target average porosity; reducing the wall thickness of the GD radial fusion CAD model to form a GD radial fusion CAD model with the wall thickness; then, a finite element simulation grid model is divided, and an inp-format simulation model file is output; importing the simulation model file in the inp format into HyperMesh software for repairing, and dividing grids to export the model in the inp file format. According to the porous scaffold designed by the invention, different functional grades of a natural bone structure are considered, and different unit cell polymorphic fusion is carried out, so that the porous scaffold better conforms to the mechanical properties of natural thighbones, and the specific surface area is increased by virtue of the lightweight design, so that more space is provided for bone cell adhesion and growth.

Three-dimensional (3D) bioreactors for large scale expansion of immune cells and methods of using the same are disclosed. The 3D bioreactor comprises: at least one packed bed chamber comprising at least one porous scaffold; at least one porous scaffold coated with one or more extracellular matrix proteins (ECMs); at least one container containing a fluid medium configured to flow through the packed bed chamber having at least one porous coated scaffold; and at least one population of immune cells suspended in a fluid medium wherein the at least one porous scaffold coated with the ECM creates a fixed niche with low shear force that mimics the natural growth environment of the immune cells and allows large scale expansion of the population of immune cells flowing through the coated porous scaffold.

The invention relates to the technical field of biomedical materials, in particular to an oral repair film and a preparation method and application thereof. The oral repair membrane comprises an electrostatic spinning membrane with the porosity of 30%-40%, and polymer microspheres, recombinant humanized collagen and mussel mucoprotein which are attached to the electrostatic spinning membrane, wherein the particle size of the polymer microspheres is 25 [mu] m-50 [mu] m. According to the oral cavity repairing film provided by the invention, by combining a polymer electrostatic spinning technology, a shearing and emulsifying microsphere preparation technology, a microsphere slow release technology and a three-dimensional porous bracket freeze-drying technology, the problems that a repairing film in the marketed or published technology is small in contact area and needs to be sewn are solved; the tissue regeneration can be efficiently stimulated, the treatment time is shortened, the treatment effect is improved, suturing is not needed, and clinical operation is facilitated.

Method for generating a porous injectable scaffold that includes providing a liquid composition of 2 phases at a temperature below 25° C., of Newtonian behavior, where the composition comprises:a liquid dispersant phase at room temperature formed by a gelatin with a low melting point, less than 15° C., functionalized with methacryloyl or methacrylamide groups; and a photoinitiator;and a dispersed phase, of microdroplets or beads in solid state, of a gelatin solution with a melting point greater than 25° C.;initiating the polymerization of the dispersing phase by light radiation; raising the temperature to 35-40° C. and allowing melting of the dispersed phase; and obtaining a porous scaffold.The formed porous scaffold and its use as a biological support for tissue regeneration / generation; as a biological matrix as a support for cells, for cell invasion; as an acellular biological matrix, a biological matrix as a mechanical support and / or a biological matrix for active components.

The invention provides a high-energy-absorption impact-resistant aluminum-based composite material, the aluminum-based composite material comprises a ceramic porous scaffold and an aluminum alloy base material, the ceramic porous scaffold is formed by compounding porous aerogel and an S-type electrostatic spinning membrane, and the aluminum alloy base material comprises the following components: 0.2-0.8 wt% of Cu, 0.2-0.8 wt% of Ni, 0.2-0.8 wt% of Ti, 0.2-0.8 wt% of Ti, and the balance of Al. The content of Mg is 0.6 to 1.2 weight percent; the content of Zn is 0.2 to 0.5 wt%; the content of Mn is 0.1 to 0.2 wt%; the content of Y is 0.05 to 0.25 weight percent; and the balance of Al. According to the invention, the ceramic skeleton is used as a reinforcing phase, and pores of the ceramic skeleton are filled with the aluminum alloy through a molten aluminum alloy pressure infiltration process, so that a novel composite structure is formed. According to the structure, the characteristics of high strength and high energy absorption of the ceramic material are brought into full play, and the brittleness of the ceramic is effectively relieved through the plastic deformation capacity of the aluminum alloy, so that the overall shock resistance and the energy absorption capacity of the material are remarkably improved.

The invention belongs to the technical field of material preparation, and particularly relates to a superstructure glassy carbon material and application thereof. The invention firstly provides a porous scaffold structure. The porous scaffold structure has a stable structure in which stress in all directions is uniformly distributed; the porous scaffold structure takes a unit cell of a three-period minimum curved surface as a minimum repetitive unit; the unit cell of the three-period minimal curved surface comprises a diamond or diamond-like structure; the porous scaffold structure is made of a high-molecular polymer. Further, the superstructure glass carbon material can be obtained by pyrolyzing the porous scaffold structure. By designing a porous structure with uniform stress and stable mechanics, the high-strength glassy carbon material with accurate and controllable shape and size is developed, and the high-strength glassy carbon material has good application prospects in multiple fields.

A material and method are disclosed such that the material can be used to form functional metal pieces by producing an easily sintered layered body of dried metal paste. On a microstructural level, when dried, the metal paste creates a matrix of porous metal scaffold particles with infiltrant metal particles, which are positioned interstitially in the porous scaffold's interstitial voids. For this material to realize mechanical and processing benefits, the infiltrant particles are chosen such that they pack in the porous scaffold piece in a manner which does not significantly degrade the packing of the scaffold particles and so that they can also infiltrate the porous scaffold on heating. The method of using this paste provides a technique with high rate and resolution of metal part production due to a hybrid deposition / removal process.

A biologic matrix comprises a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized, suspension-dried mammalian organ or tissue. The scaffold features a porous structure with a plurality of interconnected pores originating from one or more of its outer surfaces. The pores are created by forcing a gas through the vascular pathways of the mammalian organ or tissue while it is in a suspended position. This enables the gas to inflate the vascular pathways in all directions without restriction. The porous configuration substantially enhances the scaffold's effective surface area, making it at least 10 times greater than that of a non-porous scaffold having equivalent outer dimensions. In certain embodiments, the surface area considering the interconnected pores can be 15 times larger or more than the non-porous scaffold of equivalent outer dimensions.

The present invention provides a method for producing spheroids and cellular by-products of spheroids, such as extracellular vesicles. The method comprises providing a bioreactor having a cavity for culturing cells; inserting a cell into the cavity to form a spheroid; and perfusing a cell culture medium through the cavity to culture the spheroid. A porous scaffold may be soluble or insoluble, and the cells are inoculated into pores of the porous scaffold, where the cells aggregate in the pores of the porous scaffold to form spheroids. The bioreactor is continuously perfused for large scale spheroid production and enables collection of spheroids and / or extracellular vesicles or other components from cell secretory groups.

The invention belongs to the field of cell biology, and particularly relates to a preparation method and application of an extracellular matrix of cell-engineered human collagen. The preparation method comprises the following steps: S1, culturing human induced pluripotent stem cells or a cell culture comprising the human induced pluripotent stem cells, and directly inducing differentiation to obtain induced mesenchymal stem cells or a cell culture comprising the induced mesenchymal stem cells; and S2, carrying out 3D culture on the induced mesenchymal stem cells through a 3D porous scaffold carrier. The extracellular matrix prepared by the preparation method provided by the invention is rich in collagen, so that the mesenchymal stem cells can be better promoted to be differentiated into osteoblasts, and meanwhile, a new thought is provided for the preparation of the collagen.

The invention discloses a method for designing a bionic bone scaffold based on unit cell size gradient change, and belongs to the field of biological material design. The method comprises the following steps: calculating the overall wall thickness of FCC, TH and G cell size gradient models according to the required porosity; a unit is selected as a unit cell size radial gradient, in order to better simulate a natural bone structure, the overall porous structure morphology is designed as a cylinder model, and the unit cell sizes of the outer layer and the inner layer of each model are designed as required; the overall porosity of the three novel porous structure scaffolds reaches 55% by changing the wall thickness; carrying out mechanical property testing on the novel porous structure; observing the compression deformation behavior of each model and recording the numerical results of the elastic modulus and the yield strength after simulation; the designed novel porous scaffold has different functional gradients in the radial direction, and the application range of the energy absorption material unit in bionic bone scaffold design is expanded.

The present disclosure relates to methods of treating, preventing, or modulating diabetes in a patient in need thereof using a device for transplanting cells into a host body, specifically a method of treating diabetes in a patient in need thereof, comprising: implanting a device in the patient, wherein the device comprises: a porous scaffold comprising an immunologically compatible polymer mesh forming the walls of at least one chamber, an opening at either or both of a proximal end and a distal end of the chamber, at least one removable, non-porous plug configured to be positioned within the lumen of the at least one chamber, maintaining the device in the patient's body until the device is infiltrated with vascular and connective tissues; and infusing the chamber with cells, wherein at least some of the cells express insulin

The invention belongs to the technical field of implant materials, and discloses a porous titanium-based implant material surface calcium-phosphorus coating and a preparation method thereof. According to the method, a porous titanium-based implant material is used as a cathode, an annular platinum electrode is used as an anode, the cathode is located in the center of the annular electrode, a solution containing calcium and phosphorus is used as an electrolyte, biomimetic mineralization is carried out under the condition of pulse micro-potential, and the calcium-phosphorus coating is formed on the surface of the porous titanium-based implant material. According to the method, the biomimetic mineralization process of the surface of the beam structure in the porous titanium-based material is regulated and controlled by adopting the annular electrode and the weak electric field, migration of ions and ion groups in the porous scaffold is improved by adjusting the current of the annular electrode and combining the biomimetic mineralization process, and the porous titanium-based implant material uniformly covered with the calcium-phosphorus coating is obtained. The method is simple, and uniform covering of the calcium-phosphorus coating of the porous titanium-based implant material is achieved.

The utility model relates to electric heating equipment, and aims to provide a multi-tube electric heater using a porous bracket with a flanging structure. The electric heater comprises a plurality of electric heating pipes which are arranged in parallel and at intervals, and the wiring end of each electric heating pipe penetrates through a flange and is fastened and installed. At least one support with a plurality of holes is further arranged on the electric heating pipes, and the electric heating pipes penetrate through the holes in the support to achieve auxiliary supporting and reinforcing. The body of the support is of an integrated sheet structure, and the edge of each opening of the body is provided with a flanging structure perpendicular to the body of the support. The flanging structure is tightly embedded in the electric heating pipe in a riveting mode, and the outer side edge of the flanging structure is fixedly connected with the surface of the electric heating pipe in a brazing mode. According to the installation mode, potential safety hazards caused by a crevice corrosion principle can be effectively avoided, and the service life of a product is prolonged; the double fixing modes of riveting and brazing can prevent the support from scratching an oxide layer on the surface of the electric heating pipe in the using process, and noise is completely eradicated.

A method for preparing a magnesium alloy tissue engineering scaffold with a smooth inner surface by laser powder bed fusion (LPBF) is provided. The method includes: step S1: scanning a porous scaffold, and selecting the densest filling scan parameters, where the scanning includes a single-pass contour scan and a single-pass filling scan; step S2: optimizing a contour scan strategy according to the densest filling scan parameters; step S3: acquiring a corresponding melt pool dimension, and adjusting a spot compensation value based on the optimized contour scan strategy; and step S4: preparing a magnesium alloy tissue engineering scaffold based on the contour scan strategy and the adjusted spot compensation value. The method eliminates powder adhesion and sagging defects inside the complex porous structure that severely affect inner surface roughness and scaffold performance, thereby the pore connection, fatigue and corrosion resistance will be improved greatly.

The invention belongs to the technical field of biomedical materials, and particularly relates to an intelligent degradable three-dimensional porous scaffold with piezoelectric activity and a preparation method and application thereof. According to the method, the piezoelectric white calcium phosphate and the degradable metal material which are in a proper proportion are subjected to ultrasonic mixing, so that the piezoelectric white calcium phosphate is uniformly adsorbed on the surface of the degradable metal material in a physical adsorption mode, and then the composite powder obtained through mixing is subjected to 3D printing; the three-dimensional porous scaffold which is excellent in mechanical property, good in biological safety, sensitive in piezoelectric responsiveness and capable of adaptively regulating and controlling the degradation rate is prepared, a good supporting effect is provided for a critical bone defect part, meanwhile, the stress condition of the critical bone defect part is sensitively sensed, micro-current is generated in the three-dimensional porous scaffold through the stress effect, and the three-dimensional bone defect part is obtained. According to the invention, degradation of the degradable metal material and generation of new bones are promoted, and the degradation rate is adaptively adjusted according to the stress, so that the degradation rate is matched with the bone remodeling rate, and bone remodeling is effectively promoted.

The invention discloses a preparation method and application of a citric acid-based polymer stable amorphous calcium phosphate porous scaffold for bone defect repair. The preparation method of the citric acid-based polymer stable amorphous calcium phosphate porous scaffold comprises the following steps: carrying out a polymerization reaction on an amorphous calcium phosphate precursor and citric acid-based poly (1, 8-octylene glycol-citrate) at 80 DEG C for 2-3 days or carrying out a polymerization reaction at 80 DEG C for 3 days and then carrying out a reaction at 120 DEG C for 1 day to obtain the porous scaffold with stable amorphous calcium phosphate characteristics. According to the present invention, the uniform dispersion and the effective and stable combination of the amorphous calcium phosphate precursor particles in the citric acid-based poly (1, 8-octylene glycol-citrate) matrix are achieved, and the biomimetic mineralized bone repair scaffold with characteristics of porous structure, high mechanical strength, controllable degradability and excellent osteogenic activity is successfully constructed. According to the stent, the technical problem of insufficient stability in application of amorphous calcium phosphate is remarkably solved, the osteogenic activity of the material is improved, and the stent has a great application prospect in the field of clinical bone defect repair.

To provide a composition and a method for modulating an immune system in a subject.SOLUTION: A composition and a method provide means for treating and / or preventing a disease associated with deficiency and / or dysregulation of a T-cell. The composition can include: a porous scaffold, a growth factor which is present at approximately 1ng to approximately 1000ng per scaffold, and an effective amount for inducing formation of a tissue or an organ in the scaffold and mobilizing cells into the scaffold; and a differentiation factor which induces differentiation of mobilized cells into a T-cell precursor cell.SELECTED DRAWING: None

An apparatus includes a porous scaffold characterized by a scaffold refractive index. The optically written optical component is embedded in the porous scaffold. The coating forms a surface of the porous scaffold. The coating includes a surface and a transition region. The surface is characterized by a surface refractive index. The transition region features a refractive index gradient that transitions between the surface refractive index and the stent refractive index.

The invention discloses a metal gel composite osteochondral repair porous scaffold material based on a heterogeneous double-layer bonding technology and a preparation method of the metal gel composite osteochondral repair porous scaffold material. The specific process comprises the following steps: 1) obtaining an inorganic magnesium alloy porous lower-layer bracket by adopting a metal 3D printing technology; (2) mixing a cartilage differentiation promoting growth factor and a nano-carrier loaded with the cartilage differentiation promoting growth factor into methacrylated I-type collagen serving as a matrix, and carrying out 3D printing to obtain an organic porous upper-layer bracket; (3) carrying out polarization treatment on the to-be-bonded surface of the lower-layer bracket by using a plasma surface activation technology, and pre-infiltrating the to-be-bonded surfaces of the upper-layer bracket and the lower-layer bracket by using a water-absorbing self-curing adhesive; and (4) bonding an upper-layer scaffold and a lower-layer scaffold, and aging the adhesive to obtain the metal gel composite osteochondral repair porous scaffold material based on the heterogeneous double-layer bonding technology. The repairing porous scaffold material has an inorganic lower-layer structure and an organic upper-layer structure which are organically combined by using a bonding technology, so that the problem of simultaneously repairing bones and cartilages is solved in a targeted manner.

The invention provides a shape memory nano short fiber stent with self-adaptive capacity and preparation and application thereof, and belongs to the technical field of tissue engineering materials. The preparation method comprises the following steps: firstly, preparing flexible polylactic acid-fullerol composite nanofibers containing uniformly dispersed fullerol nanocrystals by utilizing an electrospinning technology, then dividing the flexible polylactic acid-fullerol composite nanofibers into short fibers by virtue of homogenization and freeze-drying processes, and assembling the short fibers into a three-dimensional porous scaffold by taking chitosan as an adhesive. The porous scaffold material disclosed by the invention has excellent biological characteristics and a water-triggered shape memory effect, and due to the fact that chitosan has excellent antioxidant activity and inherent bone induction characteristics, the nanofiber scaffold with the controllable and recoverable shape developed by the invention is expected to effectively promote osteoporotic bone healing.

The invention discloses a mechanically controllable composite membrane material, which comprises a three-dimensional porous scaffold composed of bacterial cellulose, and bioactive ceramic nanoparticles are uniformly dispersed in and on the surface of the three-dimensional porous scaffold; the bioactive ceramic nanoparticles are one or more of tricalcium phosphate, bioactive glass, calcium silicate and hydroxyapatite. According to the invention, the bioactive ceramic nanoparticles are uniformly loaded inside and on the surface of the three-dimensional porous scaffold formed by bacterial cellulose, and the composite membrane material can be endowed with a unique biological function by adjusting the types of the bioactive ceramic nanoparticles. The composite membrane material prepared by an in-situ, ectopic or chemical deposition method and the like can realize synergy and balance of mechanical properties and biological functions, and the structural design of the composite membrane material provides necessary mechanical support and also gives consideration to flexible fit with fragile nervous tissues, so that the composite membrane material has a wide application prospect in the field of neurosurgery.