26 results about "Biodegradable hydrogels" patented technology

The invention relates to the technical field of hydrogel spray preparations, in particular to hydrogel containing plant exosomes as well as a preparation method and application of the hydrogel. The invention provides hydrogel containing plant exosomes, the hydrogel comprises plant exosome freeze-dried powder and a hydrogel base solution, and the plant exosome freeze-dried powder comprises houttuynia cordata exosome powder, aloe exosome powder and honeysuckle exosome powder in a mass ratio of (1-2): (2-4): (1-2). The plant exosome compound has excellent effects of resisting inflammation, inhibiting bacteria and promoting epidermal cell proliferation; the plant exosome and the temperature-sensitive hydrogel are subjected to complementary synergism in the medication mode and the treatment effect, the temperature-sensitive hydrogel containing the plant exosome can effectively increase the diabetic foot ulcer wound repair speed, and the hydrogel can slowly release the exosome and treatment factors contained in the exosome to achieve the treatment effect. The selected biodegradable hydrogel is quick and long in curative effect, and the influence of waste generated after treatment on the environment is not increased.

The disclosure relates to a spacer using a hydrogel for treatment that aids in growth or bonding of living tissues after surgery or treatment of joints, muscles, or ligaments. The spacer includes a support sheet formed of a biodegradable hydrogel material having a water-soluble polymer network structure, and a pouch formed of a biodegradable material, as a sealing bag-shaped member surrounding the support sheet, and the support sheet is formed to dissolve in a body fluid faster than the pouch. Therefore, the spacer and a method of manufacturing the spacer according to the disclosure may eliminate cost and stress because there is no need for a subsequent removal operation, while stabilizing a surgical site and reducing pain, and particularly, adjust a drug delivery rate adaptively according to different recovery rates or tissue regeneration rates for different ages of patients.

This invention provides a transcervical access system for moving fluids transcervically. [Solution] The transcervical access system 100 is effective in transferring a wide range of fluids into the uterine cavity, including the delivery of a hydrogel precursor, saline solution, and imaging fluid. The transcervical access system 100 is also effective in removing fluids, such as residual bodily fluids, residual fluids from procedures, or tissue from the uterine cavity. The transcervical access system 100 includes a flow limiter, such as an outflow limiter 106 and / or a cervical plug. A method of using the transcervical access system 100 involves using the transcervical access system 100 to transcervically access the uterine cavity and to install the hydrogel. The transcervical access system 100 and related methods are useful in preventing adhesions after intrauterine procedures by providing a biodegradable hydrogel within the uterine cavity, including the cervix.

A dye scavenger is provided that comprises a biodegradable hydrogel formed of at least one polymer chemically cross-linked by a cross-linker. The dye scavenger removes dyes rapidly, is prepared in an environmentally friendly manner, is reusable and biodegradable and can optionally incorporate other features of laundry compositions. The dye scavenger is useful for preventing dye transfer between fabrics in laundry and for removing dyes from waste water.

The present invention relates to a bio-orthogonal, biodegradable hydrogel for sustained drug delivery, a method for preparing a bio-orthogonal, biodegradable hydrogel, the use thereof as an implantable material in the treatment of disease, and a method for preparing the same. As well as kits for preparing the hydrogels in situ at a treatment site and methods of treatment using the hydrogels or kits, such as for the treatment of ocular diseases.

A morphing, biologically-derived actuator can be used with soft robotics in a marine environment. The actuator is fabricated using a modified hydrogel additive manufacturing printing process, where the printed structure is exposed to various concentrations of crosslinking initiator to ensure a water-tight seal between adjacent printed layers. The actuator fabricated using the disclosed process is suitable for marine use and is safe for marine animals and is biodegradable.

The present invention relates to a nerve conduit comprising: a conduit body that connects both sides of a severed nerve within a living body; a triboelectric generator electrically connected to the severed nerve through the conduit body to transmit an electrical signal generated by the application of ultrasound to the severed nerve; and an encapsulation layer covering the triboelectric generator, wherein the conduit body, the triboelectric generator, and the encapsulation layer are made of biodegradable materials. This invention is an output of the research project "SONOSTIM: Ultrasound-Based Triboelectric Generator Applied to Electronic Nerve Stimulation Technology for Pain-Free Peripheral Nerve Stimulation," supported by the Ministry of SMEs and Startups, managed by the Korea Technology and Information Promotion Agency for SMEs, as part of the Entrepreneurship-Oriented University Program (Project ID: 20176104), with Energy Mining as the executing institution. The research period was from 1 May 2023, to 31 December 2023.

The present disclosure relates to a travoprost sustained release biodegradable intracameral Implant comprising a biodegradable hydrogel and travoprost particles. The present disclosure also relates to travoprost particles optionally obtained by or obtainable by a process comprising a membrane emulsification step. The present disclosure also relates to a method of manufacturing travoprost particles, optionally wherein the method comprises a membrane emulsification step. The present disclosure also relates to a method of manufacturing a travoprost sustained release biodegradable intracameral implant. The present disclosure also relates to a method of treating an ocular disease, such as glaucoma or ocular hypertension, comprising administering the travoprost particles or inserting the intracameral implant of the present disclosure into an eye of a subject in need of treatment.

The present invention discloses Wound Healer (9), a bioelectric bandage designed to accelerate wound healing, prevent infections, and provide real-time monitoring for better patient care. The device consists of a Silicon layer (1) and a Plastic outer layer (2) for durability and flexibility. It features an Electric pulse generator (3) that delivers controlled electrical stimulation to enhance cell regeneration and improve blood circulation. A Power source (4) ensures continuous operation, while embedded sensors, including a pH sensor (5), Temperature Sensor (6), and Moisture Sensor (7), monitor wound conditions and detect infections in real-time. Data from these sensors is processed by an Embedded Microchip (8), which wirelessly transmits alerts to healthcare providers. The self-sustaining power system harnesses energy from body movement, heat, or wound fluids, eliminating the need for external batteries. Designed with a biodegradable hydrogel structure, Wound Healer (9) conforms to various wound types and dissolves naturally after healing, ensuring pain-free removal. This innovative bandage enhances wound care by reducing recovery time, minimizing complications, and improving patient outcomes.

The application discloses a kind of fast swelling, enzyme catalytic degradation hydrogel and its preparation method and application, in the present application based on by sucrose molecule connection multi-arm hydrophilic polymer crosslinked hydrogel, and the swelling rate is fast, and the swelling rate is high, and in the environment of sucrose enzyme degradation rate is fast, can be widely used for preparing in enzyme response biodegradable hydrogel carrier and promote weight loss product.

The present invention discloses a digestive tract perforation occluder and a preparation method thereof. The occluder includes a matrix, the matrix includes a columnar occlusion part, and anti-detachment parts are fixedly connected to both ends of the occlusion part respectively. In at least one direction of the cross-section, the size of the occlusion part is smaller than that of the anti-detachment part, and the matrix is made of a biodegradable hydrogel. The occluder of the present invention can quickly occlude digestive tract perforations and has the potential for clinical application.

A nano hydrogel based on histamine derivatives and a preparation and application method thereof, belonging to the technical field of medical polymer materials and chemical drugs, the present invention prepares a novel biodegradable novel reduction-responsive nano hydrogel based on histamine derivatives by precipitation polymerization, and evaluates its application potential in nano drug delivery systems. The nano hydrogel prepared by the present invention has good stability and reduction sensitivity. Since the nano hydrogel is formed by covalent cross-linking, its stability is significantly higher than that of other nano hydrogels prepared by self-assembly of intermolecular forces. It also contains a large number of amide groups and imidazole groups, and shows a high drug loading capacity or encapsulation efficiency for a variety of chemotherapy drugs and nucleic acids with different structures, showing good application prospects in cancer treatment and diagnosis.

The invention relates to a modified Ti3C2TX MXene hydrogel material for enhancing photo-thermal antibiosis by releasing NO through H2O2 excitation and a preparation method of the modified Ti3C2TX MXene hydrogel material. The system is constructed by a degradable hydrogel dressing, MXene and MXene (at) TiO2 with excellent photo-thermal and oxidation resistance, a biologically safe NO donor L-Arg and low-level H2O2. Under 808nm NIR short-time irradiation, the surface temperature of the material is raised to 46-50 DEG C, NO release is promoted, and photo-thermal / NO release synergistic enhanced antibiosis is achieved. Meanwhile, the hydrogel can be used for quickly healing wounds and regenerating skin organs.

This invention discloses a cerebral vascular targeted therapy and neuromodulation system based on magnetically controlled microcapsules, belonging to the field of medical device and neuromodulation technology. The system includes a magnetic navigation device, an alternating magnetic field generator, microcapsules, and a delivery catheter. The shell of the microcapsule is made of biodegradable hydrogel, internally loaded with magnetic nanoparticles and therapeutic drugs, and optionally, a contrast agent. The microcapsule is released into the vicinity of a targeted intracranial blood vessel through the delivery catheter. Under the combined action of a static magnetic field and a gradient magnetic field, the microcapsule navigates and positions itself within complex and tortuous small blood vessels. Subsequently, the alternating magnetic field drives the microcapsule to generate mechanical vibration or rotation, enhancing the contact and diffusion of local drugs with thrombi or lesions, improving the treatment efficiency for distal small vessel thrombosis, local infections, or tumors. When close to a specific brain region, the magnetomechanical or magnetothermal effects of the microcapsule can also provide controllable stimulation to local neurons, achieving high spatial resolution neuromodulation. Compared with traditional mechanical thrombectomy, systemic thrombolysis, and transcranial magnetic / electrical stimulation, this invention improves targeting and spatial accuracy while ensuring minimally invasiveness and reducing the risk of systemic side effects.

The present invention provides a nanoparticle with which it is possible, safely, efficiently, and stably over a long period of time, to introduce siRNA used for RNA interference into an intervertebral disk cell. This nanoparticle is used for prevention or treatment of intervertebral disk degeneration, and has a biodegradable hydrogel and a ribonucleic acid molecule that is retained by a particle of the biodegradable hydrogel and that selectively inhibits an activity of a mammalian target of rapamycin (mTOR) complex.

In its first aspect, the present invention provides a biodegradable hydrogel and a method for preparing the same. The biodegradable hydrogel comprises components A and B: Component A comprises the following: NHS-PEG-NHS, halide-PEG-halide, and solvent A is water or saline solution; Component B comprises the following: a macromolecular substance containing an amino group, and solvent B is water or saline solution. This method utilizes a reaction between succinimide groups and amino groups to form a gel, instantly fixing wounds in situ. Subsequently, a slow reaction between halogen elements and tertiary amines forms a gel, enhancing the gel's modulus while producing quaternary ammonium groups with antibacterial properties, thus improving the system's antibacterial efficacy. Furthermore, the gel exhibits hemostatic, self-healing, and tissue repair properties.

The present invention discloses a fully degradable hydrogel-coated coil and a preparation method thereof. The fully degradable hydrogel-coated coil comprises a coil body, wherein a hydrogel drug-loading coating is coated on the surface of the coil body, an anti-unwinding wire is arranged inside the coil body, the coil body is a degradable body, and the material of the degradable body is a degradable substrate containing a developing material. The fully degradable hydrogel-coated coil and the preparation method thereof provided by the present invention have the characteristics of complete degradability, good biocompatibility, dense packing property, excellent developing performance, and safety and reliability.

Systems and methods are described for sorting and selecting cells by immobilizing or surrounding the cells within a degradable hydrogel chamber, the method comprising: (a) providing a fluid device, the fluid device comprising: (i) a channel including a surface, (ii) a spatial energy modulation element in optical communication with the surface, and (iii) a detector in optical communication with the surface and operably associated with the spatial energy modulation element; (b) loading the channel with cells and one or more polymer precursors such that the cells are disposed on or proximate to the surface thereof; (c) immobilizing selected cells based on one or more optical signals derived from the cells, the immobilizing being by synthesizing one or more gel structures; and (d) removing unselected cells from the channel.

This invention discloses a multi-objective generation system and method for implantable biodegradable hydrogel sustained-release carriers in the biomedical field. By constructing a systematic generation architecture that integrates material component gradient design, dynamic modeling of mechanical response, and closed-loop regulation of biocompatibility, and through the synergistic effect of a triple mechanism of molecular-level crosslinking network topology reconstruction, degradation kinetic parameter coupling optimization, and active adaptation of the interface microenvironment, the degradation rate, structural strength maintenance ability, and tissue integration performance of the hydrogel are simultaneously and precisely controlled during its in vivo service life. This overcomes the technical defects of existing technologies, such as premature softening failure or aggravated local inflammatory response caused by single-dimensional regulation. It realizes the gradient design of the internal structure of the hydrogel from macro to micro, enabling the material to autonomously adjust its stiffness distribution according to the local stress state when subjected to complex physiological loads, avoiding the sudden mechanical collapse caused by the overall degradation of traditional homogeneous hydrogels.

A controlled release device for improved plant growth and increased stress resistance, comprising an active ingredient encapsulated in a biodegradable hydrogel matrix, wherein the active ingredient is astaxanthin, which reduces oxidative stress, and wherein the hydrogel matrix controls the release of the astaxanthin over a longer period of time.

LABORATORY EQUIPMENT FOR BIODEGRADABLE HYDROGEL FILM USING PVP-CMC WITH BACTERIAL CELLULOSE SUPPORT.

The present invention relates to bioorthoscopic biodegradable hydrogels for sustained-release drug delivery, methods for preparing bioorthoscopic biodegradable hydrogels, their use as implantable materials in the treatment of diseases, kits for preparing hydrogels in situ at the treatment site, and methods of treatment using hydrogels or kits, such as for treating eye diseases.

The present invention relates to a system for generating a degradable hydrogel, a method for generating a degradable hydrogel, and a kit for generating a degradable hydrogel.

An insect bait includes a hydrogel substrate and a formulation on the hydrogel substrate. The formulation includes glycerol and boric acid. Preparing an insect bait includes preparing a conditioning solution with an active ingredient and hydrating a hydrogel substrate with the conditioning solution.

In general terms, the present invention provides an implantable bioelectronic device (100, 300, 1102). The implantable bioelectronic device comprises a flexible base material (102) having a top layer and a bottom layer opposite thereto, the flexible base material comprising at least one electrode (104) and a plurality of holes (106); a biological sample (108, 202, 1106) seeded on the top layer; and a biodegradable hydrogel (110, 1108), wherein the implantable bioelectronic device, when in use in-vitro, enables the biological sample to grow on the top layer prior to a coating thereof with the biodegradable hydrogel, and wherein the implantable bioelectronic device, when in use in-vivo, enables connecting a first element (114) and a second element (116) for restoration of an interrupted biological function therebetween. The present invention also provides a method of using the aforesaid implantable bioelectronic device. The method comprises performing an in-vitro activity for cell culture on the implantable bioelectronic device and an in-vivo activity comprising implanting the implantable bioelectronic device into a subject at a desired location.

The invention discloses a multifunctional gel mulching film with multiple layers of slow-release urea as well as preparation and application of the multifunctional gel mulching film. The preparation method comprises the following steps: firstly adsorbing and wrapping urea by adopting a biomass raw material, then coating by using a negative electricity polymer to form more stable slow-release nanoparticles, adding polyvinyl alcohol to coat a plate, and finally treating by using an alcohol acid solution to prepare the slow-release nano-material which has good mechanical property and surface hydrophobicity and can be used for preparing the slow-release nano-material. And meanwhile, the multifunctional biodegradable hydrogel mulching film has multiple layers of slow-release urea.