15 results about "Biodegradable hydrogels" patented technology

This invention provides a transcervical access system for moving fluids transcervically. [Solution] The transcervical access system 100 is effective in transferring a wide range of fluids into the uterine cavity, including the delivery of a hydrogel precursor, saline solution, and imaging fluid. The transcervical access system 100 is also effective in removing fluids, such as residual bodily fluids, residual fluids from procedures, or tissue from the uterine cavity. The transcervical access system 100 includes a flow limiter, such as an outflow limiter 106 and / or a cervical plug. A method of using the transcervical access system 100 involves using the transcervical access system 100 to transcervically access the uterine cavity and to install the hydrogel. The transcervical access system 100 and related methods are useful in preventing adhesions after intrauterine procedures by providing a biodegradable hydrogel within the uterine cavity, including the cervix.

The present invention relates to a bio-orthogonal, biodegradable hydrogel for sustained drug delivery, a method for preparing a bio-orthogonal, biodegradable hydrogel, the use thereof as an implantable material in the treatment of disease, and a method for preparing the same. As well as kits for preparing the hydrogels in situ at a treatment site and methods of treatment using the hydrogels or kits, such as for the treatment of ocular diseases.

A morphing, biologically-derived actuator can be used with soft robotics in a marine environment. The actuator is fabricated using a modified hydrogel additive manufacturing printing process, where the printed structure is exposed to various concentrations of crosslinking initiator to ensure a water-tight seal between adjacent printed layers. The actuator fabricated using the disclosed process is suitable for marine use and is safe for marine animals and is biodegradable.

The present disclosure relates to a travoprost sustained release biodegradable intracameral Implant comprising a biodegradable hydrogel and travoprost particles. The present disclosure also relates to travoprost particles optionally obtained by or obtainable by a process comprising a membrane emulsification step. The present disclosure also relates to a method of manufacturing travoprost particles, optionally wherein the method comprises a membrane emulsification step. The present disclosure also relates to a method of manufacturing a travoprost sustained release biodegradable intracameral implant. The present disclosure also relates to a method of treating an ocular disease, such as glaucoma or ocular hypertension, comprising administering the travoprost particles or inserting the intracameral implant of the present disclosure into an eye of a subject in need of treatment.

The application discloses a kind of fast swelling, enzyme catalytic degradation hydrogel and its preparation method and application, in the present application based on by sucrose molecule connection multi-arm hydrophilic polymer crosslinked hydrogel, and the swelling rate is fast, and the swelling rate is high, and in the environment of sucrose enzyme degradation rate is fast, can be widely used for preparing in enzyme response biodegradable hydrogel carrier and promote weight loss product.

This invention discloses a cerebral vascular targeted therapy and neuromodulation system based on magnetically controlled microcapsules, belonging to the field of medical device and neuromodulation technology. The system includes a magnetic navigation device, an alternating magnetic field generator, microcapsules, and a delivery catheter. The shell of the microcapsule is made of biodegradable hydrogel, internally loaded with magnetic nanoparticles and therapeutic drugs, and optionally, a contrast agent. The microcapsule is released into the vicinity of a targeted intracranial blood vessel through the delivery catheter. Under the combined action of a static magnetic field and a gradient magnetic field, the microcapsule navigates and positions itself within complex and tortuous small blood vessels. Subsequently, the alternating magnetic field drives the microcapsule to generate mechanical vibration or rotation, enhancing the contact and diffusion of local drugs with thrombi or lesions, improving the treatment efficiency for distal small vessel thrombosis, local infections, or tumors. When close to a specific brain region, the magnetomechanical or magnetothermal effects of the microcapsule can also provide controllable stimulation to local neurons, achieving high spatial resolution neuromodulation. Compared with traditional mechanical thrombectomy, systemic thrombolysis, and transcranial magnetic / electrical stimulation, this invention improves targeting and spatial accuracy while ensuring minimally invasiveness and reducing the risk of systemic side effects.

The present invention provides a nanoparticle with which it is possible, safely, efficiently, and stably over a long period of time, to introduce siRNA used for RNA interference into an intervertebral disk cell. This nanoparticle is used for prevention or treatment of intervertebral disk degeneration, and has a biodegradable hydrogel and a ribonucleic acid molecule that is retained by a particle of the biodegradable hydrogel and that selectively inhibits an activity of a mammalian target of rapamycin (mTOR) complex.

In its first aspect, the present invention provides a biodegradable hydrogel and a method for preparing the same. The biodegradable hydrogel comprises components A and B: Component A comprises the following: NHS-PEG-NHS, halide-PEG-halide, and solvent A is water or saline solution; Component B comprises the following: a macromolecular substance containing an amino group, and solvent B is water or saline solution. This method utilizes a reaction between succinimide groups and amino groups to form a gel, instantly fixing wounds in situ. Subsequently, a slow reaction between halogen elements and tertiary amines forms a gel, enhancing the gel's modulus while producing quaternary ammonium groups with antibacterial properties, thus improving the system's antibacterial efficacy. Furthermore, the gel exhibits hemostatic, self-healing, and tissue repair properties.

This invention discloses a multi-objective generation system and method for implantable biodegradable hydrogel sustained-release carriers in the biomedical field. By constructing a systematic generation architecture that integrates material component gradient design, dynamic modeling of mechanical response, and closed-loop regulation of biocompatibility, and through the synergistic effect of a triple mechanism of molecular-level crosslinking network topology reconstruction, degradation kinetic parameter coupling optimization, and active adaptation of the interface microenvironment, the degradation rate, structural strength maintenance ability, and tissue integration performance of the hydrogel are simultaneously and precisely controlled during its in vivo service life. This overcomes the technical defects of existing technologies, such as premature softening failure or aggravated local inflammatory response caused by single-dimensional regulation. It realizes the gradient design of the internal structure of the hydrogel from macro to micro, enabling the material to autonomously adjust its stiffness distribution according to the local stress state when subjected to complex physiological loads, avoiding the sudden mechanical collapse caused by the overall degradation of traditional homogeneous hydrogels.

A controlled release device for improved plant growth and increased stress resistance, comprising an active ingredient encapsulated in a biodegradable hydrogel matrix, wherein the active ingredient is astaxanthin, which reduces oxidative stress, and wherein the hydrogel matrix controls the release of the astaxanthin over a longer period of time.

LABORATORY EQUIPMENT FOR BIODEGRADABLE HYDROGEL FILM USING PVP-CMC WITH BACTERIAL CELLULOSE SUPPORT.

The present invention relates to bioorthoscopic biodegradable hydrogels for sustained-release drug delivery, methods for preparing bioorthoscopic biodegradable hydrogels, their use as implantable materials in the treatment of diseases, kits for preparing hydrogels in situ at the treatment site, and methods of treatment using hydrogels or kits, such as for treating eye diseases.

The present invention relates to a system for generating a degradable hydrogel, a method for generating a degradable hydrogel, and a kit for generating a degradable hydrogel.

An insect bait includes a hydrogel substrate and a formulation on the hydrogel substrate. The formulation includes glycerol and boric acid. Preparing an insect bait includes preparing a conditioning solution with an active ingredient and hydrating a hydrogel substrate with the conditioning solution.

The invention discloses a multifunctional gel mulching film with multiple layers of slow-release urea as well as preparation and application of the multifunctional gel mulching film. The preparation method comprises the following steps: firstly adsorbing and wrapping urea by adopting a biomass raw material, then coating by using a negative electricity polymer to form more stable slow-release nanoparticles, adding polyvinyl alcohol to coat a plate, and finally treating by using an alcohol acid solution to prepare the slow-release nano-material which has good mechanical property and surface hydrophobicity and can be used for preparing the slow-release nano-material. And meanwhile, the multifunctional biodegradable hydrogel mulching film has multiple layers of slow-release urea.