4 results about "Biodegradable hydrogels" patented technology

This invention discloses a cerebral vascular targeted therapy and neuromodulation system based on magnetically controlled microcapsules, belonging to the field of medical device and neuromodulation technology. The system includes a magnetic navigation device, an alternating magnetic field generator, microcapsules, and a delivery catheter. The shell of the microcapsule is made of biodegradable hydrogel, internally loaded with magnetic nanoparticles and therapeutic drugs, and optionally, a contrast agent. The microcapsule is released into the vicinity of a targeted intracranial blood vessel through the delivery catheter. Under the combined action of a static magnetic field and a gradient magnetic field, the microcapsule navigates and positions itself within complex and tortuous small blood vessels. Subsequently, the alternating magnetic field drives the microcapsule to generate mechanical vibration or rotation, enhancing the contact and diffusion of local drugs with thrombi or lesions, improving the treatment efficiency for distal small vessel thrombosis, local infections, or tumors. When close to a specific brain region, the magnetomechanical or magnetothermal effects of the microcapsule can also provide controllable stimulation to local neurons, achieving high spatial resolution neuromodulation. Compared with traditional mechanical thrombectomy, systemic thrombolysis, and transcranial magnetic / electrical stimulation, this invention improves targeting and spatial accuracy while ensuring minimally invasiveness and reducing the risk of systemic side effects.

This invention discloses a multi-objective generation system and method for implantable biodegradable hydrogel sustained-release carriers in the biomedical field. By constructing a systematic generation architecture that integrates material component gradient design, dynamic modeling of mechanical response, and closed-loop regulation of biocompatibility, and through the synergistic effect of a triple mechanism of molecular-level crosslinking network topology reconstruction, degradation kinetic parameter coupling optimization, and active adaptation of the interface microenvironment, the degradation rate, structural strength maintenance ability, and tissue integration performance of the hydrogel are simultaneously and precisely controlled during its in vivo service life. This overcomes the technical defects of existing technologies, such as premature softening failure or aggravated local inflammatory response caused by single-dimensional regulation. It realizes the gradient design of the internal structure of the hydrogel from macro to micro, enabling the material to autonomously adjust its stiffness distribution according to the local stress state when subjected to complex physiological loads, avoiding the sudden mechanical collapse caused by the overall degradation of traditional homogeneous hydrogels.

The present invention relates to bioorthoscopic biodegradable hydrogels for sustained-release drug delivery, methods for preparing bioorthoscopic biodegradable hydrogels, their use as implantable materials in the treatment of diseases, kits for preparing hydrogels in situ at the treatment site, and methods of treatment using hydrogels or kits, such as for treating eye diseases.