19 results about "Nonunion" patented technology

The invention discloses an isolator for establishing a bone nonunion animal model and a preparation method of the isolator, and relates to the technical field of medical instruments, and the preparation method comprises the following steps: step 1, obtaining a hydrogen-containing silicone oil prepolymer with a side chain containing Si-H bonds; 2, obtaining a silica gel macromonomer with an epoxy group on a side chain; step 3, obtaining an anti-inflammatory functionalized silica gel macromonomer; 4, reconstructing the skeleton model in a three-dimensional manner, and creating a defect isolator model; 5, adding the anti-inflammatory functionalized silica gel macromonomer obtained in the step 3 and a reactive diluent into a mixing tank, adding a cross-linking agent and polyether modified polydimethylsiloxane under mechanical stirring, stirring for 30 minutes, defoaming for 2 hours under 500Pa vacuum, and standing and curing in a darkroom after defoaming; and 6, a multi-material-box DLP photocuring 3D printer is adopted for isolator printing. According to the method, observation interference on the bone nonunion pathological process is fundamentally reduced, and high-fidelity modeling construction is achieved.

The utility model discloses a novel bone fracture plate for treating bone nonunion of humerus, which relates to the technical field of bone fracture plates, and comprises an internal connection rotating piece mounted in a bone fracture plate main body, according to the device, the internal connecting rotating piece is installed, the inclined face of the internal connecting rotating piece is matched with the angle adjusting piece with the inclined face, and therefore a doctor only needs to rotate the angle adjusting piece and the internal connecting rotating piece when needing to obliquely install a connecting screw, and the angle adjusting piece rotates around the axis (namely the rotating axis) of a connecting boss; meanwhile, the internal connection rotating part is rotated, so that the inclined plane position of the internal connection rotating part is spatially changed, the angle of the angle adjusting part of the inclined plane can be adjusted, the mounting angle of the connecting screw can be changed to a certain extent, the angle of the connecting screw of the device can be adjusted, and the device can be adjusted according to the age and the body shape of a patient. Therefore, a doctor can select a proper angle to obliquely hit a screw at a proper position to connect the screw.

The present invention provides an absorbable hemostatic bone wax and a preparation method thereof, belonging to the technical field of hemostatic materials. The wax comprises poloxamer and a random copolymer of ethylene oxide and propylene oxide, with a mass ratio of 3-7:3-7. The absorbable hemostatic bone wax is a waxy solid material with good plasticity and adhesion. It is used to control bleeding from bone wounds and is completely degraded and absorbed within one month after use, avoiding the risk of bone nonunion and infection caused by foreign body space occupation.

The present invention relates to a recombinant humanized type III collagen-hydroxyapatite composite bone repair material and its preparation method and application. At present, the industry has always expected to achieve efficient production of macromolecular humanized collagen or whole human collagen, which is a technical difficulty that is difficult to completely break through. The molecular weight of the recombinant humanized type III collagen of the present invention is close to that of natural collagen; at the same time, its encoding gene is optimized to achieve efficient and secretory expression of recombinant collagen with high yield. The composite bone repair material prepared with the collagen of the present invention has a more uniform microstructure than the products prepared with commercially available natural collagen or type III human collagen, and achieves the combination of hydroxyapatite grains and collagen fibers at the nanoscale. At the same time, there is a multi-scale pore structure inside the material, which achieves the purpose of better biomimetic natural bone composite material preparation. Therefore, this product can be widely used in dental (jaw) bone defects, as well as dental or bone surgery such as filling and repair of bone defects, nonunion, delayed bone healing or nonunion caused by various reasons, so that more patients can benefit from it.

The present application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating nonunion of bone and its preparation method and application. The traditional Chinese medicine composition is composed of the following raw medicinal materials: Herba Epimedii 10-20 parts by weight, Radix Angelicae Pubescentis 18-25 parts by weight, Radix Eupatorium Fortunei 10-15 parts by weight, Radix Atractylodis 10-15 parts by weight, Radix Cyathulae 10-20 parts by weight, Radix Angelicae Pubescentis 10-15 parts by weight, Radix Paeoniae Rubra 10-20 parts by weight, Semen Persicae 10-15 parts by weight, and Radix Glycyrrhizae 5-10 parts by weight. The present application optimizes the compatibility of each raw medicinal material and the compatibility between the raw medicinal materials, and has the effects of promoting blood circulation to remove blood stasis, reducing swelling and relieving pain, tonifying liver and kidney, and connecting bone and tendon, and fully plays the therapeutic characteristics of traditional Chinese medicine with multiple components, multiple pathways and multiple targets, and can obviously improve the clinical healing of patients with nonunion of bone, and has good popularization and application value.

This invention discloses a novel adjustable intramedullary nail, comprising a hollow main nail, a proximal end of the nail, and a main body of the nail, which are integrally formed. The diameter of the proximal end of the nail is larger than that of the main body. Multiple through-holes for dynamic screws are provided at the proximal end of the nail. An adjustment hole is provided on the main body of the nail, away from the proximal end. A dynamic bone screw is installed in each of the dynamic screw holes and can move axially along the holes. A tail cap is installed on the proximal side of the nail, and an elastomer is placed between the tail cap and the dynamic bone screw. An absorbable washer is placed distal to the dynamic bone screw to support it. An adjustment device for adjusting the stress at the fracture ends is provided on the main body of the nail, which can adjust the stress at the fracture ends according to the specific fracture conditions, avoid stress shielding at the fracture ends, accelerate fracture healing, reduce delayed healing and nonunion, and decrease the incidence of refracture after removal of the intramedullary nail.

Systems and devices for bone fracture fixations are described. The system enables the closed reduction of bone fracture fixation by means of a conformable fixed-angle fracture fixation device. The fixed angle fracture fixation device utilizes a series of fixation elements to secure the fracture at multiple fixed angles reducing the risk of nonunion, implant failure and the likelihood for patients to undergo subsequent operations.

The application relates to the technical field of femoral neck fracture treatment, in particular to a femoral neck bionic internal fixation system, which comprises a sliding sleeve, a lever top rod, an anti-rotation screw, a fixing screw and a hollow sliding rod, the sliding sleeve is fixed on a femur through the fixing screw, the anti-rotation screw is horizontally arranged, the sliding sleeve and the sliding rod are obliquely arranged, one end of the sliding rod is slidably connected in the sliding sleeve, a strip-shaped hole is formed in the sliding rod and used for penetrating the anti-rotation screw, the lever top rod is used for being inserted into the sliding rod to limit and bear the anti-rotation screw, and a lever top rod limiting nut is connected to the lower end of the lever top rod. The anti-rotation screw is horizontally arranged, the sliding rod is obliquely arranged, and the two constitute a bionic triangular area structure, so that the femoral head is stably fixed, the problem of poor anti-rotation and anti-shearing force effect in the prior art is solved, the interference on the blood supply outside the femoral head is reduced, and the possibility of nonunion and femoral head necrosis is reduced.

This invention discloses an isolator for establishing an animal model of bone nonunion and its preparation method, relating to the field of medical device technology, including the following steps: Step 1: Obtaining a hydrogen-containing silicone oil prepolymer with Si-H bonds in the side chain; Step 2: Obtaining a silicone macromonomer with epoxy groups in the side chain; Step 3: Obtaining an anti-inflammatory functionalized silicone macromonomer; Step 4: Three-dimensionally reconstructing a bone model to create an isolator model at the defect site; Step 5: Adding the anti-inflammatory functionalized silicone macromonomer obtained in Step 3 and an active diluent to a mixing tank, adding a crosslinking agent under mechanical stirring, adding polyether-modified polydimethylsiloxane, stirring for 30 minutes, degassing under 500Pa vacuum for 2 hours, and then allowing it to stand and mature in a dark room; Step 6: Printing the isolator using a multi-cartridge DLP photopolymerization 3D printer. This invention fundamentally reduces interference with the observation of the pathological process of bone nonunion and achieves high-fidelity modeling and construction.

The utility model discloses a femoral intramedullary nail which comprises a main nail, the main nail comprises a far-end section, a near-end section and a connecting piece used for connecting the far-end section and the near-end section, the connecting piece comprises a first section and a second section, the first section is in threaded connection with the far-end section, and the second section is in threaded connection with the near-end section. Through relative rotation of the near-end section and the far-end section, the upper part and the lower part, needing to be corrected, of the near end of the femur are adjusted to reach a proper matching angle, the structure is simple, rotation correction bone setting treatment is specially carried out on the near end of a child, controlled rotation correction is allowed, and the device is mainly designed for near-end fracture, malformation healing, bone nonunion and malformation.

The invention discloses a collagen composite artificial bone which is characterized in that raw materials comprise type I collagen and hydroxyapatite, and further comprise one or more of polylactic acid, polyglycolic acid, a polylactic acid-glycolic acid copolymer, polycaprolactone, poly (trimethylene carbonate), polymethyl methacrylate, hyaluronic acid and alginic acid. According to the collagen composite artificial bone, one or more specific high polymer materials are added in the preparation process of the artificial bone, so that the collagen composite artificial bone has excellent mechanical properties and stability, and the preparation method is simple, easy in expanded production, high in yield and low in cost. The artificial bone is suitable for various application fields such as various bone fractures with bone defects, nonunion or deformity healing, orthopedic bone grafting, other bone defect repair without bone grafting taboo in the orthopedics department and the like.

Systems and devices for bone fracture fixations are described. The system enables the closed reduction of bone fracture fixation by means of a conformable fixed-angle fracture fixation device. The fixed angle fracture fixation device utilizes a series of fixation elements to secure the fracture at multiple fixed angles reducing the risk of nonunion, implant failure and the likelihood for patients to undergo subsequent operations.

The present application provides a proximal femoral intramedullary fixation device, relates to the technical field of orthopedic implants, and comprises a main nail, a tension screw and a compression nail assembly. The compression nail assembly comprises a compression nail, an elastic element below the compression nail and a ratchet pawl assembly. The proximal end of the main nail is provided with a tension screw hole for installing the tension screw and a central hole for installing the compression nail assembly. One side of the tension screw is provided with a sawtooth groove. The ratchet pawl assembly comprises a pawl and two ratchets. The pawl is connected with the elastic element. The two ratchets are arranged along the axial direction of the main nail and are engaged with each other. One of the ratchets is engaged with the pawl, and the other ratchet is engaged with the sawtooth groove. When the tension screw retreats to the lower right, the sawtooth groove drives the two ratchets to rotate, so that the engagement position of the pawl with one of the ratchets is changed. The compression nail assembly cooperates with the sawtooth groove, the compression is one-way stroke, the fracture is connected tightly and cannot be pulled apart, and the phenomena of bone nonunion and malunion caused by poor fracture fixation are effectively avoided.

The application discloses an intramedullary fixation device for femoral intertrochanteric fracture, which comprises a nail body, a cavity extending along a longitudinal axis from a proximal end to a distal end is arranged in the nail body, a force carrier system is arranged on the nail body to create a dynamic control at a human femoral neck and femoral head to eliminate stress shielding and realize controllable transverse dynamic force, the force carrier system comprises a movable assembly arranged at the proximal end of the nail body and at least one sliding piece arranged at the distal end of the nail body, the movable assembly serves as a main power source of the transverse dynamic force while playing a connecting and fixing role on the femoral neck and femoral head, and the sliding piece is used for the movable connection between the distal end of the nail body and the femoral body. The application can decompose the stress concentration and stress shielding of the locking nail on the intramedullary nail, enhances the bending strength, and realizes the stability of biomechanics. The proximal end of the intramedullary nail is coated with titanium, has a high friction coefficient, provides initial stability and long-term bone ingrowth effect, and can effectively reduce the occurrence of broken nail, bone nonunion and delayed bone healing.

The invention discloses application of a mesenchymal stem cell combined platelet in preparation of a preparation for treating bone nonunion, the mesenchymal stem cell combined platelet (platelet-rich plasma) is adopted to treat bone nonunion, the treatment effect is remarkable, the operation is simpler, the treatment period is short, and the application of the mesenchymal stem cell combined platelet in preparation of the preparation for treating bone nonunion has no toxic or side effect. The platelet-rich plasma can generate a large number of factors for promoting fracture healing, growth and development, and can improve expression of a growth mechanism in the fracture healing process so as to promote formation of callus, effectively promote growth and reproduction and osteogenic differentiation of bone marrow mesenchymal stem cells (BM-SCs), promote chondrogenic differentiation of the mesenchymal stem cells in a fracture affected part, and promote osteogenic differentiation of the bone marrow mesenchymal stem cells (BM-SCs). Cell repair and regeneration are carried out on a fracture affected part, fracture healing can be effectively promoted, and bone nonunion can be treated more efficiently.

This application discloses a medical data processing method, apparatus, equipment, and medium for nonunion healing analysis, relating to the field of medical and health information technology. The method includes: quantitatively processing CT images and biochemical indicators of the target area to obtain fracture gap parameters and microenvironment biological activity scores; inputting the gap parameters, activity scores, and implant information into a multidimensional etiology association model to calculate etiology weight vectors; extracting visual morphological feature vectors from CT images at multiple scales using a three-dimensional image network; constructing and simulating a three-dimensional finite element model based on CT images and implant information to obtain biomechanical feature vectors; weighting and fusing visual and mechanical features according to the etiology weight vectors to obtain cross-modal collaborative features; and processing the data through a multi-task prediction network to obtain scoring auxiliary data and dynamic healing prediction curves. This application can obtain accurate quantitative analysis reference data based on multi-source heterogeneous medical data to assist in the classification assessment of nonunion and the prediction of dynamic healing trends.

The bone plate (1) according to the invention is particularly suitable for treating fractures or non-unions and for osteotomies of the olecranon and the proximal ulna. The bone plate (1) has the following parts:a distal longitudinal shaft portion (2) having a number of plate holes (11);a longitudinal central axis (3); anda proximal head part (4), which is widened compared to the distal shaft part and has two holes (5; 6) with the hole axes (7, 8) arranged on opposite sides of the central axis (3), wherein the head part (4) is bent down relative to the shaft part (2).The two holes (5, 6) are suitable for receiving a polyaxial locking screw at an angle of ±15° relative to the respective hole axis (7; 8) or a non-locking standard screw, with the two hole axes (7, 8) forming an angle α.

A bioactive orthopedic implant is provided defined as a rod with a surface and a treated surface area for increased surface area, a freeze-dried hydrophilic hydrogel network physically cross-linked via charged polymers and salt-ions onto the treated surface area, biologies trapped and thereby hosted within the hydrogel network, and covalently reactive macromonomers chemically cross-linked within the hydrogel network to strengthen the hydrogel network itself and to the rod. The surface area of the bioactive orthopedic implant can be coated with covalently linkable molecules which are chemical cross-linked with the covalently reactive macromonomers to increase adhesion of the chemically and physically cross-linked hydrophilic hydrogel network to the rod. The rod can be an interconnected porous rod and where the biologies is hosted with pores of the interconnected porous rod. The bioactive orthopedic implant can be sized for implantation in between two bone segments, a bone tunnel, or a fracture.

The invention discloses an application of 6-shogaol in preparation of a medicine for promoting skeletal muscle regeneration and / or repair. The 6-shogaol can activate stationary-stage muscle satellite cells, promote myoblast differentiation and myotube fusion, guide damaged broken end new muscle fiber connection and realize structure repair. Meanwhile, 6-shogaol can inhibit excessive deposition of collagen, reduce scar formation and promote functional regeneration. In the fracture accompanied with muscle injury, the bone healing quality is synergistically enhanced by improving the soft tissue environment and vascularization, new bone formation is increased, and the problem of bone nonunion caused by muscle injury is solved. In a word, the 6-shogaol can solve the pain point that the physical injury of the skeletal muscle is difficult to heal through the dual mechanisms of promoting muscle regeneration and resisting fibrosis, and cooperatively promotes the accompanying bone injury repair. The application is different from conventional osteoporosis treatment or disuse atrophy treatment, and has definite clinical pertinence and application value.