Biologically cmposite artificial bone and its preparing process

A preparation process and technology of artificial bone, applied in the field of artificial bone, can solve the problems of complex preparation of BMP, difficult degradation and absorption of bioceramics, poor mechanical strength of collagen, etc., to reduce immune rejection, obvious osteoconduction effect, and accurate osteoinductive effect. Effect

Inactive Publication Date: 2002-01-09
赵建华 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of BMP being implanted into the bone defect for osteoinduction, BMP alone is easy to lose with body fluids and cannot fully exert its effective effect, so it needs to be compounded with a carrier to exert its effect. At present, the main method is to use freeze-drying method to adsorb BMP on porous Polyglycolic acid (PGA) or polylactic acid (PLA) or bioceramics or deproteinized bone and collagen micropores to achieve sustained release of BMP and induce osteogenesis
Although this material has obtained good animal ex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: a kind of biocomposite artificial bone, is characterized in that: it is the biocomposite artificial bone that is made by the raw material of following weight (part) proportion, polylactic acid: hydroxyapatite: decalcified bone matrix=2 :1:1.

[0021] Its preparation process is as follows: First, hydroxyapatite and decalcified bone matrix are pulverized into powder respectively, passed through a standard sieve, and the grain powder with a particle size of less than 250um is taken, and prepared according to the ratio of hydroxyapatite: decalcified bone matrix = 1:1 Mix the ratio evenly, add an appropriate amount of distilled water and stir to make a suspension; then weigh D, L-type polylactic acid according to the ratio of polylactic acid: hydroxyapatite: decalcified bone matrix = 2:1:1, and add ethyl acetate to dissolve , the amount of ethyl acetate is based on the ability to completely dissolve D, L-type polylactic acid; secondly, add ethyl acetate contain...

Embodiment 2

[0044] Embodiment 2: a kind of biocomposite artificial bone, is characterized in that: it is the biocomposite artificial bone that is made by the raw material of following weight (part) proportion, polylactic acid: hydroxyapatite: decalcified bone matrix=1.5 :1.5:0.5.

[0045] The preparation process of this example is the same as that of Example 1.

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Abstract

An artificial bone is prepared from polylactic acid (1.5-2 wt. portions), hydroxy apatite (1-1.5) and decalicified bone matrix (0.5-1) through emulsion mixing method where ethyl acetate and absolute alcohol are used as solvent. Its advantages include no damage to human body and good bone transfer and induction actions. It can be used for treating dysostosis and nonunion.

Description

(1) Technical field [0001] The invention relates to an artificial bone, in particular to a biocomposite artificial bone for treating bone defect and nonunion and its preparation process. (2) Background technology [0002] As we all know, bone defects and nonunions are common clinical sequelae of bone trauma and infection. How to repair bone defects and nonunions has always been a thorny issue in the field of orthopedics. At present, the commonly used repair materials include autologous bone, allogeneic bone, and artificial synthetic substitutes. These materials all have certain deficiencies in varying degrees, such as autologous bone transplantation. Although it has no immune rejection, the cells and bioactive molecules in the transplanted bone It can continue to survive at the recipient site and perform corresponding functions to promote the healing of bone defects, which is unmatched by other materials, but this material is limited, its size and shape are often limited, an...

Claims

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Application Information

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IPC IPC(8): A61K31/74A61L27/14A61L27/44
Inventor 赵建华柳峰王远亮
Owner 赵建华
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