Biologically cmposite artificial bone and its preparing process

Abstract

An artificial bone is prepared from polylactic acid (1.5-2 wt. portions), hydroxy apatite (1-1.5) and decalicified bone matrix (0.5-1) through emulsion mixing method where ethyl acetate and absolute alcohol are used as solvent. Its advantages include no damage to human body and good bone transfer and induction actions. It can be used for treating dysostosis and nonunion.

Description

(1) Technical field [0001] The invention relates to an artificial bone, in particular to a biocomposite artificial bone for treating bone defect and nonunion and its preparation process. (2) Background technology [0002] As we all know, bone defects and nonunions are common clinical sequelae of bone trauma and infection. How to repair bone defects and nonunions has always been a thorny issue in the field of orthopedics. At present, the commonly used repair materials include autologous bone, allogeneic bone, and artificial synthetic substitutes. These materials all have certain deficiencies in varying degrees, such as autologous bone transplantation. Although it has no immune rejection, the cells and bioactive molecules in the transplanted bone It can continue to survive at the recipient site and perform corresponding functions to promote the healing of bone defects, which is unmatched by other materials, but this material is limited, its size and shape are often limited, an...

AI Technical Summary

Problems solved by technology

In the process of BMP being implanted into the bone defect for osteoinduction, BMP alone is easy to lose with body fluids and cannot fully exert its effective effect, so it needs to be compounded with a carrier to exert its effect. At present, the main method is to use freeze-drying method to adsorb BMP on porous Polyglycolic acid (PGA) or polylactic acid (PLA) or bioceramics or deproteinized bone and collagen micropores to achieve sustained release of BMP and induce osteogenesis

Although this material has obtained good animal experiment results, it is still difficult to transition to clinical application. The main reasons are 1. The preparation of BMP is complicated and expensive; 3. Polyglycolic acid and polylactic acid have the accumulation of acidic products after degradation, and bioceramics have the disadvantage of being difficult to degrade and absorb; 4. It is difficult to remove calcium-binding protein from deproteinized bone, and there is still some immune rejection Reaction; 5. Collagen has poor mechanical strength and cannot withstand stress