131 results about "Hydroxy apatite" patented technology

The invention relates to the technical field of skull repair, and discloses a personalized 3D printing porous composite hydroxyapatite coating skull repair body which comprises a truss structure, a plurality of porous areas are distributed on the truss structure, bionic bone trabecula structures are integrally formed in the porous areas, the truss structure is composed of hollow pipes communicating with one another, and the hollow pipes communicate with one another. A plurality of small holes and micro holes which are communicated with the interior of the hollow pipe are formed in the hollow pipe, and a composite coating of a hydroxyapatite coating and titanium is sprayed on the porous area; the invention provides a personalized 3D printed skull restoration with a porous composite hydroxyapatite coating. The problem that the biocompatibility, the bone induction capability and the bone ingrowth effect of an existing skull restoration need to be improved is solved.

The invention discloses a titanium-based hydroxyapatite composite coating and a preparation method thereof. The problems that a traditional coating is weak in interface bonding, single in porosity and mismatched in drug sustained release are solved. The composite coating comprises a gradient component layer and a bionic porous outer layer which are sequentially stacked on the surface of a titanium substrate, wherein the gradient component layer comprises a bottom layer (a titanium-based hydroxyapatite transition layer, 70-80% of HA and bonded through Ti-O bonds) and a middle layer (an HA / bioglass composite layer, 50-70% of HA and 10-20% of bioglass); the bionic porous outer layer is a porous HA layer, the porosity is 40-60%, the porosity is gradually increased in a gradient mode in the direction away from the titanium substrate, surface layer pores are loaded with anti-infection drugs, and inner layer pores are loaded with bone growth factors. The method realizes improvement of the interface bonding strength of the coating, consideration of mechanical and biological activity and staged slow release of the medicine, and is suitable for the field of bone joint implantation.

The invention provides an interface-enhanced regenerated bone scaffold for sustained-release medicines as well as a preparation method and application of the interface-enhanced regenerated bone scaffold, and belongs to the technical field of bone tissue engineering. According to the invention, polycaprolactone and hydroxyapatite are taken as matrix components of the regenerated bone scaffold, so that the regenerated bone scaffold has mechanical strength matched with a host bone and good biocompatibility; the polydopamine coating is loaded on the surface and internal pores of the regenerated bone scaffold matrix, surface functional modification is easy to perform, and a catechol structure in the polydopamine coating can perform coordination binding with metal ions in MOFs, so that the falling rate of MOFs particles is reduced, and the MOFs particles are uniformly and stably distributed; the MOFs particles are used for loading the eucommia ulmoides extract, safety and non-toxicity are achieved, the eucommia ulmoides extract is encapsulated in the MOFs particles, the stability of the eucommia ulmoides extract can be improved, and a better drug release effect and a better bone regeneration promoting effect are achieved.

This invention discloses a composite coating for the tooth surface of an atlantoaxial PEEK interbody fusion cage, relating to the field of medical materials technology. The composite coating for the atlantoaxial PEEK interbody fusion cage comprises a transition layer covering the tooth surface of the atlantoaxial PEEK interbody fusion cage and a hydroxyapatite coating on the surface of the transition layer; the transition layer is obtained by mixing modified nano-hydroxyapatite and modified PEEK; the hydroxyapatite coating is obtained by plasma spraying of nano-hydroxyapatite. This application sets a transition layer between the PEEK and the hydroxyapatite coating, effectively addressing the problem of easy coating detachment due to the difference in physicochemical properties between the PEEK and hydroxyapatite coatings. The composite coating prepared in this application improves the bonding strength between the coating and the substrate, and the prepared material can be used in biological organisms for a long time.

The invention discloses a nanofiber functional grading scaffold and a preparation method thereof. The preparation method comprises the following steps: step 1, respectively preparing a PLCL / silk fibroin spinning solution, a PLCL / silk fibroin / MDP1 spinning solution and a PLCL / silk fibroin / hydroxyapatite spinning solution; 2, processing the three spinning solutions into nanofiber yarns through electrostatic spinning; and step 3, by taking the PLCL / silk fibroin nanofiber yarns as warp yarns and taking the three kinds of nanofiber yarns as weft yarns in sequence, weaving on a machine to obtain the stent. In the nanofiber functional grading scaffold, polypeptide MDP1 is loaded in the nanofiber yarn for simulating a fibrous cartilage interface, so that the situation that the mechanical property of the whole structure is influenced by scar hyperplasia caused by excessive inflammation of a tendon-bone interface can be prevented; meanwhile, hydroxyapatite with an excellent osteogenesis promoting effect is loaded in the nanofiber yarn for simulating the bone interface, and the mechanical property of the tendon-bone interface is further enhanced.

The invention belongs to the technical field of orthopedic implants, and particularly relates to a porous bone grafting-free window type interbody fusion cage and a preparation method thereof. The multi-hole type bone grafting window-free interbody fusion cage comprises a frame body which comprises four side faces and two end faces, and the four side faces are of hollow structures; the space defined by the frame body is filled with the porous structure body; the meshing teeth are arranged on the upper surface and the lower surface of the frame body; and the clamping structure is arranged at one end part of the frame body. According to the porous bone grafting-free window type interbody fusion cage, due to the design of the bone grafting-free window, the complexity of the use process is reduced, the operation is convenient, and the possibility that the fusion cage is polluted is reduced; the porous structure body with the bionic bone trabecula can be printed through 3D printing, and pore channels for bone tissue to grow in and a surface beneficial to cell adhesion can be effectively provided; the hydroxyapatite coating improves the biological activity of the surface of the base material and enhances the interface integration of the interbody fusion cage and the upper and lower end plates of the vertebral body.

The present invention discloses a biomimetic enamel composite material, which is a composite of ceramic hydroxyapatite nanowires and a polymer organic polymer assembled in an oriented manner; the biomimetic enamel composite material has a multi-level, multi-scale, and multi-component overall orientation structure; the hardness of the biomimetic enamel composite material is 2.5 - 5.5 GPa, the modulus is 40 - 60 GPa, the viscoelastic loss factor is tanδ = 0.03 - 0.04, and the viscoelastic quality factor is 1.5 - 2.5. The biomimetic enamel composite material is used as an upper restoration material for oral medical implants and is used for the integrated preparation of oral implant abutments and crowns. The present invention also discloses a preparation method of the biomimetic enamel composite material. The present invention has broad application prospects in clinical dental crowns, upper healing abutments of oral implants, repair abutments, and abutment integrated crowns in oral medicine.

Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 μm to 800 μm and the composition has a texture value above about 1000. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.

The invention relates to an enamel repair material and a preparation method thereof, and belongs to the technical field of medical filling materials for tooth defects, the enamel repair material comprises F-HAp, APTES-ZrO2, MPC modified composite resin, 10-MDP, gamma-MPS, a composite initiator, MPC and a dispersant; f-HAp is a fluorine-doped enamel-like hydroxyapatite nanorod, and F-HAp is a fluorine-doped enamel The APTES-ZrO2 is nano zirconium oxide modified by aminopropyl triethoxy silane, and the nano zirconium oxide modified by the aminopropyl triethoxy silane is The MPC modified composite resin is 2-methacryloyloxyethyl phosphorylcholine grafted and modified dimethyl acrylic acid carbamate and glycidyl methacrylate elastomer composite resin; the F-HAp, APTES-ZrO2 and MPC modified composite resin is prepared by adopting a special method, and is compounded with other components according to a certain proportion to obtain the enamel repair material, so that the enamel repair material has good cohesiveness, strength and biocompatibility and excellent leakage resistance, and the use safety and durability are improved.

The invention discloses an orthopedic implant with antibacterial and osteogenesis-promoting characteristics and a preparation method thereof, and belongs to the technical field of medical materials.The preparation method comprises the steps that a titanium stent subjected to acid treatment is placed in a NaOH solution, and a sodium titanate coating is formed on the surface of the titanium stent after alkali heat treatment; after annealing, immersing into a mixed solution of EDTA-CaNa2 and NaH2PO42H2O, and after heating reaction, forming a hydroxyapatite coating on the surface of the sodium titanate coating; immersing the hydroxyapatite coating into a mixed solution of glucolactone and sodium alginate, controlling the pH value of the mixed solution to be 5, and forming a porous hydrogel coating on the surface of the hydroxyapatite coating after reaction; and soaking the loaded medicine to obtain the orthopedic implant. A multi-layer structure of the sodium titanate coating, the hydroxyapatite coating and the porous hydrogel coating is sequentially formed on the titanium alloy stent, and finally, the medicine is loaded, so that the titanium alloy stent has various characteristics of resisting bacteria, promoting osteogenesis and the like.

The invention relates to the technical field of microorganisms, in particular to a lactobacillus paracasei strain and application thereof. The preservation number of the lactobacillus paracasei strain is CGMCC (China General Microbiological Culture Collection Center) No.27975. The lactobacillus paracasei disclosed by the invention can tolerate an oral environment, inhibit proliferation of streptococcus mutans and remarkably inhibit adhesion of the streptococcus mutans on a hydroxyapatite tooth model; the level of producing water-insoluble exopolysaccharides by streptococcus mutans is reduced, the formation of a dental plaque biofilm caused by streptococcus mutans is effectively reduced, the content of a mature dental plaque biofilm is reduced, and the biofilm is not easy to form; the expression quantity of cariogenic genes gtfB, gtfC, gtfD, ftf and LuxS of streptococcus mutans can be obviously reduced.

The invention relates to the technical field of microorganisms, in particular to a viable bacterium preparation with the effect of preventing or treating decayed teeth as well as a preparation method and application of the viable bacterium preparation. The viable bacterium preparation comprises a lactobacillus paracasei strain and auxiliary materials, and the preservation number of the lactobacillus paracasei strain is CGMCC (China General Microbiological Culture Collection Center) No.27975. The viable bacterium preparation can inhibit the proliferation of streptococcus mutans and significantly inhibit the adhesion of streptococcus mutans on a hydroxyapatite tooth model; the level of producing water-insoluble exopolysaccharides by streptococcus mutans is reduced, the formation of a dental plaque biofilm caused by streptococcus mutans is effectively reduced, the content of a mature dental plaque biofilm is reduced, and the biofilm is not easy to form; the expression quantity of cariogenic genes gtfB, gtfC, gtfD, ftf and LuxS of streptococcus mutans can be obviously reduced.

The invention provides a porous titanium alloy implant double-layer slow release system and a preparation method and application thereof, and belongs to the field of biology. According to the porous titanium alloy implant double-layer slow release system, porous titanium alloy serves as a framework, first gel is loaded in the porous titanium alloy, and the porous titanium alloy is coated with second gel; the first gel contains a DNA (Deoxyribose Nucleic Acid)-like nanotube and hydroxyapatite; the second gel contains DNA-like nanotubes loaded with anti-tumor drugs, and the physicochemical properties and degradation speeds of the inner gel and the outer gel are different, so that the problem that the existing porous titanium alloy implant releases anti-tumor and osteogenesis promoting substances at the same time and lacks a space-time sequence is solved; the retention property on tumors is also improved, and a solution is provided for the poor retention property of anti-tumor drugs.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.

A dental varnish composition for promoting enamel remineralization may comprise nano-hydroxyapatite particles dispersed in a biocompatible resin matrix that forms an adhesive film on tooth enamel. The composition may include a solvent to facilitate uniform dispersion and one or more additives. The resin matrix may be hydrophilic to enhance adhesion and wetting of enamel microstructures. Contact with saliva triggers controlled, gradual release of nano-hydroxyapatite, providing sustained remineralization benefits and protection against demineralization over an extended period. The nano-hydroxyapatite may penetrate enamel microstructures and repair microlesions, while optionally reducing dentin hypersensitivity. The composition may be fluoride-free and formulated with defined weight ratios of resin, particles, and solvent. A method of treatment includes applying the varnish to tooth surfaces, forming the adhesive film, and allowing slow release of nano-hydroxyapatite to strengthen enamel.

The invention aims to provide a biodegradable deciduous tooth repairing post-core material and a preparation method thereof. Deciduous tooth caries (Deciduous tooth decay) and residual roots and crowns of deciduous teeth caused by trauma of the deciduous teeth are clinically common symptoms. A clinically common permanent tooth root pipe pile core system affects replacement of deciduous permanent teeth due to non-absorbability and cannot meet the performance requirement for repairing residual roots and crowns of the deciduous teeth. The time limit and performance requirements of clinical application are fully considered. The polylactic acid is subjected to toughening modification by a block polymerization method, so that the toughness and strength of the polylactic acid are improved, and the elasticity modulus of the polylactic acid and the elasticity modulus of deciduous teeth are within the same quantity range. According to the invention, tooth growth-promoting raw materials such as hydroxyapatite are synthesized into the post-core material, so that the post-core material has an obvious effect in the aspects of anti-caries repair. Experiments prove that the product provided by the invention has good biocompatibility, and is degradable and absorbable.

The invention discloses a polypeptide derivative, a nanofiber and application of the polypeptide derivative and the nanofiber in preparation of a product for repairing subfissure of teeth, the sequence of the polypeptide derivative comprises Nap-Phe-Phe-Gly-Asp-His-Thr-Lys-Glu, and Nap is 2-naphthylacetic acid. The polypeptide derivative is clear in chemical structure, small in molecular weight, single in component, simple in preparation process, low in cost, high in yield and easy to store. The polypeptide derivative disclosed by the invention is self-assembled in an aqueous solution to form the supramolecular hydrogel with a nanofiber microstructure, and the supramolecular hydrogel is high in stability and good in biocompatibility. The nanofiber hydrogel of the polypeptide derivative can interact with mineral ions and can form a crystal structure very close to natural hydroxyapatite, so that ordered formation of mineral crystals is induced at enamel and dentin hidden cracks.

The invention discloses a periodontal complex stent with a bionic structure and a preparation method. The preparation method comprises the following steps: step 1, preparing a polycaprolactone-polylactic acid nanofiber membrane by an electrostatic spinning method; 2, the polycaprolactone-polylactic acid nanofiber membrane obtained in the step 1 is coated with chitosan layer by layer, the fiber membrane is stacked, and after freeze drying, a polycaprolactone-polylactic acid nanofiber scaffold is obtained; 3, immersing the polycaprolactone-polylactic acid nanofiber scaffold obtained in the step 2 into a collagen solution, and carrying out self-assembly to form a composite scaffold; then immersing into a hydroxyapatite solution, and mineralizing to obtain the required composite scaffold; according to the invention, a directionally arranged PCL-PLA nanofiber scaffold is taken as a basis, the surface layer is coated with porous collagen, and after mineralization, a mineralized structure with gradient decreasing from a collagen layer in an external phase to a middle fiber layer is obtained; the obtained composite scaffold simulates a heterogeneous structure of periodontal membrane-bone interface tissue, and provides possibility for collaborative regeneration of soft and hard tissues of a periodontal complex.

The invention discloses a shapeable bone repair material capable of being implanted in a positioning manner and a preparation method thereof. The interior of the bone repair material is a core layer made of a gelatin, gallic acid and hydroxyapatite particle composite material, and the exterior of the bone repair material is a porous spongy collagen wrapping layer; the density of the wrapping layer is 20-100mg / cm < 3 >; the density of the core layer is 100-800 mg / cm < 3 >; and the particle size of the hydroxyapatite particles is 0.1-2 mm. The collagen sponge on the outer layer of the material wraps the gelatin / hydroxyapatite composite material, so that the problems of loose structure, weak binding force and displacement and powder falling after implantation of bone meal or collagen bone meal composite materials are solved, stimulation and trauma of bone meal particles to surrounding tissues can be avoided, and the conditions of bone meal discharge, bone grafting part collapse and the like are avoided. And in the self tissue regeneration process, the collagen component is degraded and absorbed, and the hydroxyapatite is fused with the new bone, so that bone regeneration is realized, and the success rate of tooth implantation can be improved.

The utility model belongs to the technical field of orthopedic implants, and particularly relates to a porous bone grafting-free window type interbody fusion cage. The multi-hole type bone grafting window-free interbody fusion cage comprises a frame body which comprises four side faces and two end faces, and the four side faces are of hollow structures; the space defined by the frame body is filled with the porous structure body; the meshing teeth are arranged on the upper surface and the lower surface of the frame body; and the clamping structure is arranged at one end part of the frame body. According to the multi-hole type bone grafting-free window type interbody fusion cage, due to the design of the bone grafting-free window, the complexity of the using process is reduced, the operation is convenient, and the possibility that the fusion cage is polluted is reduced; the porous structure body with the bionic bone trabecula can be printed through 3D printing, and pore channels for bone tissue to grow in and a surface beneficial to cell adhesion can be effectively provided; the hydroxyapatite coating improves the biological activity of the surface of the base material and enhances the interface integration of the interbody fusion cage and the upper and lower end plates of the vertebral body.

This invention discloses a method, apparatus, medium, and device for evaluating the acid-resistant repair effect of tooth enamel, relating to the field of dental prosthetics. The method includes: constructing an energy accumulation distribution model and a heat conduction model in tooth tissue under erbium laser irradiation; obtaining a calculation model for the carbonate loss distribution of tooth enamel based on the decomposition reaction of carbonated hydroxyapatite in tooth enamel at high temperatures; constructing a photo-thermal-chemical coupled two-dimensional analysis model of tooth enamel under erbium laser irradiation based on the above model; performing simulation calculations on the photo-thermal-chemical coupled two-dimensional analysis model to determine the two-dimensional temperature distribution and carbonated hydroxyapatite loss distribution inside the tooth enamel under different erbium laser intensities and frequencies, thereby determining the acid-resistant repair effect of tooth enamel. This method fills the gap in the prior art lacking quantitative evaluation methods and solves the problem of difficulty in scheme design due to the inability to accurately correlate laser parameters with the acid-resistant repair effect.

The present invention relates to a method for synthesizing calcium-based biominerals, particularly hydroxyapatite (found in vertebrate bones and teeth) and calcium carbonate (found in plankton and corals). This fully biocompatible mineralization strategy not only offer fundamental insights into the biomineralization process, starting from mineral ions to amorphous precursors and eventually to specific minerals, but also contributes to our scientific understanding of life's origin. Furthermore, it showcases great promise for therapeutic applications, such as actively repairing damaged tooth enamel and promoting bone growth.

The invention discloses a forming method and application of a nano-hydroxyapatite / polyamide 66 composite material, and the forming method of the nano-hydroxyapatite / polyamide 66 composite material comprises the following steps: forming: carrying out 3D printing forming on slurry containing the nano-hydroxyapatite / polyamide 66 composite material by adopting a fused deposition forming extrusion type 3D printer to obtain a printed piece; and post-treatment is conducted, specifically, the printed part is sequentially dried and annealed, and a formed part of the nano-hydroxyapatite / polyamide 66 composite material is obtained. The shape of the vertebral prosthesis can be customized through 3D printing based on a three-dimensional reconstruction technology of CT data of a patient, accurate matching with a complex anatomical structure is achieved, and limitation of a standardized vertebral prosthesis is avoided; the pore structure can be accurately designed, and hydroxyapatite has a micro-pore structure (lt; therefore, the product has a multi-stage pore structure, and osseointegration can be accelerated.

The invention provides a magnesium alloy-hydroxyapatite composite bone prosthesis and a preparation method thereof.The preparation method of the magnesium alloy-hydroxyapatite composite bone prosthesis comprises the following steps that a target bone is scanned through CT, and a three-dimensional model containing an appearance structure and an internal structure is obtained; simplifying the appearance structure of the bone prosthesis, simulating an internal porous structure of the bone prosthesis, and designing a three-dimensional structure of the bone prosthesis; preparing hydroxyapatite printing slurry; printing a hydroxyapatite bracket by using a three-dimensional photocuring technology; carrying out cleaning, degreasing and high-temperature sintering on the hydroxyapatite scaffold; injecting molten magnesium alloy into the hydroxyapatite stent by using a pressureless permeation technology; and removing redundant materials by adopting a cutting tool, and grinding and polishing to obtain the magnesium alloy-hydroxyapatite composite bone prosthesis. The prepared magnesium alloy-hydroxyapatite composite auditory ossicle prosthesis has the advantages of being stable in positioning, not prone to shifting and disengaging, high in sound conduction efficiency, controllable in cost and capable of achieving personalized customization.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

The invention provides a dual-network antibacterial bone repair material and a preparation method and application thereof, and relates to the technical field of biological materials, the dual-network antibacterial bone repair material comprises mineralized collagen and an antibacterial material; the mineralized collagen comprises a collagen layer and hydroxyapatite deposited and mineralized on the collagen layer; the antibacterial material and the collagen layer are mutually crosslinked. The material simulates a bone material of a minimum structural unit of a natural bone, can achieve a better osteogenic induction effect, and has better mechanical properties by taking collagen macromolecules as a scaffold; the mineralized collagen and the antibacterial material are cross-linked to form a double-network interpenetrating structure, the antibacterial material is connected with collagen macromolecules, the antibacterial function is achieved, the collagen macromolecules are indirectly connected through cross-linking of the antibacterial material, and the mechanical property of the material is further improved. The dual-network antibacterial bone repair material can simultaneously have osteogenic induction, antibacterial and early-stage good mechanical properties.

The present invention relates to a recombinant humanized type III collagen-hydroxyapatite composite bone repair material and its preparation method and application. At present, the industry has always expected to achieve efficient production of macromolecular humanized collagen or whole human collagen, which is a technical difficulty that is difficult to completely break through. The molecular weight of the recombinant humanized type III collagen of the present invention is close to that of natural collagen; at the same time, its encoding gene is optimized to achieve efficient and secretory expression of recombinant collagen with high yield. The composite bone repair material prepared with the collagen of the present invention has a more uniform microstructure than the products prepared with commercially available natural collagen or type III human collagen, and achieves the combination of hydroxyapatite grains and collagen fibers at the nanoscale. At the same time, there is a multi-scale pore structure inside the material, which achieves the purpose of better biomimetic natural bone composite material preparation. Therefore, this product can be widely used in dental (jaw) bone defects, as well as dental or bone surgery such as filling and repair of bone defects, nonunion, delayed bone healing or nonunion caused by various reasons, so that more patients can benefit from it.

The invention relates to a nano-hydroxyapatite composition added to chitosan for use after the tooth bleaching process.

The invention provides a hip joint surface replacement prosthesis suitable for severe acetabulum defects, and belongs to the technical field of medical instruments. The three-wing acetabulum outer cup prosthesis is made of metal cobalt-chromium-molybdenum materials, a titanium alloy coating and a hydroxyapatite coating are arranged on the surface of the three-wing acetabulum outer cup prosthesis, and the coatings are of a micropore structure. The upper wing, the middle wing and the lower wing are connected to the circumferential surface of the three-wing acetabulum outer cup prosthesis in a sliding mode; the upper wing, the middle wing and the lower wing of the hip joint surface replacement prosthesis are designed into shapes matched with a bone anatomical structure of a patient, so that the prosthesis can be tightly attached to an acetabulum area of the patient. According to the personalized adaptive design, necessary initial stability is immediately provided after an operation, a solid foundation is laid for early movement and recovery of a patient after the operation through a multi-point fixing mechanism, and the risk of complications caused by prosthesis looseness is reduced.

The invention relates to an in-situ lubrication 3D printing Janus bone cartilage repair scaffold and a preparation method thereof.The scaffold is prepared through 3D printing and comprises a subchondral bone layer and a cartilage layer, the subchondral bone layer is prepared from GelMA and NAGA loaded nHA, and bone healing is promoted; the cartilage layer is provided with zwitterionic monomers, and in-situ lubrication is achieved. In-situ lubrication can be realized through lubrication modification of the cartilage layer scaffold structure, and bone healing is promoted by loading hydroxyapatite on the subchondral bone layer scaffold.