67 results about "Hydroxy apatite" patented technology

The invention discloses a titanium-based hydroxyapatite composite coating and a preparation method thereof. The problems that a traditional coating is weak in interface bonding, single in porosity and mismatched in drug sustained release are solved. The composite coating comprises a gradient component layer and a bionic porous outer layer which are sequentially stacked on the surface of a titanium substrate, wherein the gradient component layer comprises a bottom layer (a titanium-based hydroxyapatite transition layer, 70-80% of HA and bonded through Ti-O bonds) and a middle layer (an HA / bioglass composite layer, 50-70% of HA and 10-20% of bioglass); the bionic porous outer layer is a porous HA layer, the porosity is 40-60%, the porosity is gradually increased in a gradient mode in the direction away from the titanium substrate, surface layer pores are loaded with anti-infection drugs, and inner layer pores are loaded with bone growth factors. The method realizes improvement of the interface bonding strength of the coating, consideration of mechanical and biological activity and staged slow release of the medicine, and is suitable for the field of bone joint implantation.

Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 μm to 800 μm and the composition has a texture value above about 1000. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.

A dental varnish composition for promoting enamel remineralization may comprise nano-hydroxyapatite particles dispersed in a biocompatible resin matrix that forms an adhesive film on tooth enamel. The composition may include a solvent to facilitate uniform dispersion and one or more additives. The resin matrix may be hydrophilic to enhance adhesion and wetting of enamel microstructures. Contact with saliva triggers controlled, gradual release of nano-hydroxyapatite, providing sustained remineralization benefits and protection against demineralization over an extended period. The nano-hydroxyapatite may penetrate enamel microstructures and repair microlesions, while optionally reducing dentin hypersensitivity. The composition may be fluoride-free and formulated with defined weight ratios of resin, particles, and solvent. A method of treatment includes applying the varnish to tooth surfaces, forming the adhesive film, and allowing slow release of nano-hydroxyapatite to strengthen enamel.

The invention aims to provide a biodegradable deciduous tooth repairing post-core material and a preparation method thereof. Deciduous tooth caries (Deciduous tooth decay) and residual roots and crowns of deciduous teeth caused by trauma of the deciduous teeth are clinically common symptoms. A clinically common permanent tooth root pipe pile core system affects replacement of deciduous permanent teeth due to non-absorbability and cannot meet the performance requirement for repairing residual roots and crowns of the deciduous teeth. The time limit and performance requirements of clinical application are fully considered. The polylactic acid is subjected to toughening modification by a block polymerization method, so that the toughness and strength of the polylactic acid are improved, and the elasticity modulus of the polylactic acid and the elasticity modulus of deciduous teeth are within the same quantity range. According to the invention, tooth growth-promoting raw materials such as hydroxyapatite are synthesized into the post-core material, so that the post-core material has an obvious effect in the aspects of anti-caries repair. Experiments prove that the product provided by the invention has good biocompatibility, and is degradable and absorbable.

The invention discloses a shapeable bone repair material capable of being implanted in a positioning manner and a preparation method thereof. The interior of the bone repair material is a core layer made of a gelatin, gallic acid and hydroxyapatite particle composite material, and the exterior of the bone repair material is a porous spongy collagen wrapping layer; the density of the wrapping layer is 20-100mg / cm < 3 >; the density of the core layer is 100-800 mg / cm < 3 >; and the particle size of the hydroxyapatite particles is 0.1-2 mm. The collagen sponge on the outer layer of the material wraps the gelatin / hydroxyapatite composite material, so that the problems of loose structure, weak binding force and displacement and powder falling after implantation of bone meal or collagen bone meal composite materials are solved, stimulation and trauma of bone meal particles to surrounding tissues can be avoided, and the conditions of bone meal discharge, bone grafting part collapse and the like are avoided. And in the self tissue regeneration process, the collagen component is degraded and absorbed, and the hydroxyapatite is fused with the new bone, so that bone regeneration is realized, and the success rate of tooth implantation can be improved.

The utility model belongs to the technical field of orthopedic implants, and particularly relates to a porous bone grafting-free window type interbody fusion cage. The multi-hole type bone grafting window-free interbody fusion cage comprises a frame body which comprises four side faces and two end faces, and the four side faces are of hollow structures; the space defined by the frame body is filled with the porous structure body; the meshing teeth are arranged on the upper surface and the lower surface of the frame body; and the clamping structure is arranged at one end part of the frame body. According to the multi-hole type bone grafting-free window type interbody fusion cage, due to the design of the bone grafting-free window, the complexity of the using process is reduced, the operation is convenient, and the possibility that the fusion cage is polluted is reduced; the porous structure body with the bionic bone trabecula can be printed through 3D printing, and pore channels for bone tissue to grow in and a surface beneficial to cell adhesion can be effectively provided; the hydroxyapatite coating improves the biological activity of the surface of the base material and enhances the interface integration of the interbody fusion cage and the upper and lower end plates of the vertebral body.

This invention discloses a method, apparatus, medium, and device for evaluating the acid-resistant repair effect of tooth enamel, relating to the field of dental prosthetics. The method includes: constructing an energy accumulation distribution model and a heat conduction model in tooth tissue under erbium laser irradiation; obtaining a calculation model for the carbonate loss distribution of tooth enamel based on the decomposition reaction of carbonated hydroxyapatite in tooth enamel at high temperatures; constructing a photo-thermal-chemical coupled two-dimensional analysis model of tooth enamel under erbium laser irradiation based on the above model; performing simulation calculations on the photo-thermal-chemical coupled two-dimensional analysis model to determine the two-dimensional temperature distribution and carbonated hydroxyapatite loss distribution inside the tooth enamel under different erbium laser intensities and frequencies, thereby determining the acid-resistant repair effect of tooth enamel. This method fills the gap in the prior art lacking quantitative evaluation methods and solves the problem of difficulty in scheme design due to the inability to accurately correlate laser parameters with the acid-resistant repair effect.

The present invention relates to a method for synthesizing calcium-based biominerals, particularly hydroxyapatite (found in vertebrate bones and teeth) and calcium carbonate (found in plankton and corals). This fully biocompatible mineralization strategy not only offer fundamental insights into the biomineralization process, starting from mineral ions to amorphous precursors and eventually to specific minerals, but also contributes to our scientific understanding of life's origin. Furthermore, it showcases great promise for therapeutic applications, such as actively repairing damaged tooth enamel and promoting bone growth.

The invention provides a magnesium alloy-hydroxyapatite composite bone prosthesis and a preparation method thereof.The preparation method of the magnesium alloy-hydroxyapatite composite bone prosthesis comprises the following steps that a target bone is scanned through CT, and a three-dimensional model containing an appearance structure and an internal structure is obtained; simplifying the appearance structure of the bone prosthesis, simulating an internal porous structure of the bone prosthesis, and designing a three-dimensional structure of the bone prosthesis; preparing hydroxyapatite printing slurry; printing a hydroxyapatite bracket by using a three-dimensional photocuring technology; carrying out cleaning, degreasing and high-temperature sintering on the hydroxyapatite scaffold; injecting molten magnesium alloy into the hydroxyapatite stent by using a pressureless permeation technology; and removing redundant materials by adopting a cutting tool, and grinding and polishing to obtain the magnesium alloy-hydroxyapatite composite bone prosthesis. The prepared magnesium alloy-hydroxyapatite composite auditory ossicle prosthesis has the advantages of being stable in positioning, not prone to shifting and disengaging, high in sound conduction efficiency, controllable in cost and capable of achieving personalized customization.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

The invention relates to a nano-hydroxyapatite composition added to chitosan for use after the tooth bleaching process.

This invention provides a biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold, its preparation method, and its application, relating to the technical field of tissue engineering scaffolds. The biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold comprises, from the inside out, a cementum repair layer, a periodontal ligament repair layer, and an alveolar bone repair layer; the cementum repair layer and the alveolar bone repair layer include a mineralized hydrogel layer; wherein the raw materials for preparing the mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and hydroxyapatite; the alveolar bone repair layer includes a non-mineralized hydrogel layer; wherein the raw materials for preparing the non-mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and fibrin I. This invention precisely matches the mechanical and biological requirements of each layer of the periodontal complex through a three-layer structure, a reversibly hydrazone-regulated viscoelastic gradient, and a differentiated biochemical microenvironment of nHAp / FBN1.

This invention relates to a desensitizing drug for tooth enamel repair and its preparation method, belonging to the field of biomedical technology. The drug comprises a specific ratio of paeonol-dopamine modified chitosan quaternary ammonium salt, enzyme-responsive precursor mineral, polyethylene glycol didopamine modified hydroxyapatite, strontium nitrate, hyaluronic acid-maleimide, L-cysteine, and carbomer. The paeonol-dopamine modified chitosan quaternary ammonium salt is obtained by modifying chitosan quaternary ammonium salt with paeonol and dopamine hydrochloride under tyrosinase catalysis. The enzyme-responsive precursor mineral is obtained by coating nano-calcium pyrophosphate with ε-polylysine. The polyethylene glycol didopamine modified hydroxyapatite is obtained by surface adhesion modification of hydroxyapatite with polyethylene glycol didopamine. This invention yields a restorative desensitizing gel with strong adhesion and enzyme responsiveness. This gel can form a long-lasting protective layer on the tooth surface, simultaneously achieving the triple effects of physical sealing, nerve inhibition, and active mineralization.

The invention discloses a composition for repairing tooth enamel and a preparation method of the composition. The composition comprises 10-15% by mass of bioactive glass; the bioactive glass comprises the following components by mole percent: 8%-15% of P2O5; 50%-60% of SiO2; and 30-40% of CaO. The composition disclosed by the invention can be used for repairing mineral loss caused by demineralization and restoring the structural integrity of enamel hydroxyapatite. According to the bioactive glass, the mineral deposition efficiency and enamel structure reconstruction are improved through a biomimetic mineralization mechanism, dual repair of functions and forms of enamel is achieved, the bioactive glass has remarkable advantages in enamel repair and chalk spot reversal, and an experimental basis is provided for developing efficient enamel repair agents (such as toothpaste and gel).

This invention discloses a tooth powder with whitening, stain removal, and anti-inflammatory effects, and its preparation method. The tooth powder is a compound of a whitening system, an antibacterial and anti-inflammatory system and a microbiome regulation system, a repair and abrasion system, and a taste-correcting and preservative system. Its core utilizes a specifically formulated biofilm complex enzyme, which can efficiently decompose dental plaque biofilm. Combined with sodium phytate and niacinamide, it achieves gentle whitening and stain removal; with epigallocatechin gallate and baicalin, it achieves targeted antibacterial and anti-inflammatory effects; with probiotic components, it regulates the oral microbiome; and with hydroxyapatite and 45S5 bioactive glass, it repairs tooth enamel. This invention employs customized embedding technology and a graded low-temperature preparation process, significantly improving the storage stability of the active ingredients. The tooth powder of this invention is gentle and non-irritating, does not damage tooth enamel, does not disrupt the oral microecological balance, and has multiple oral care effects with long-lasting and non-rebounding results, making it suitable for large-scale industrial production and long-term use by various population groups.

The present application relates to a kind of multifunctional pharmaceutical composition of dental comprehensive repair and its preparation method, belong to biopharmaceutical technical field, and pharmaceutical composition includes keratin peptide, coral fungus extract, eggshell derived nano calcium phosphate, catechin zinc complex, hydroxyapatite, modified chitosan-PEG gel and other components.Keratin peptide is the product between 3kDa-10kDa obtained by keratinase enzymolysis to white goose velvet;Coral fungus extract is the product obtained by cellulase, subtilisin and bromelain enzymolysis to coral fungus, and purified by G-25 dextran gel column;Modified chitosan-PEG gel is the product obtained by sodium cyanoborohydride stabilization and glycerol plasticization to the reactant of chitosan and dialdehyde polyethylene glycol.Integrated multiple functions such as antibacterial, mineralization and tissue repair, through optimizing component and dosage form, realize efficient, minimally invasive dental damage repair, and good biocompatibility and long-acting.

The invention belongs to the technical field of cartilage extracts, and particularly relates to application of a salmon nasal cartilage extract in preparation of a product for improving bone mineral density. The preparation method of the extract comprises the following steps: 1) performing low-temperature extraction on salmon nasal cartilage homogenate by using guanidine hydrochloride, centrifuging, and dialyzing to intercept total protein with the molecular weight of more than 8000; 2) adding precooled acetone into the total protein for fractional precipitation, and freeze-drying to obtain fractional precipitation protein; 3) dissolving the fractional precipitation protein in diluted hydrochloric acid, adding trypsin, and carrying out light-shielding enzymolysis to obtain an enzymatic hydrolysate; and (4) carrying out hydroxyapatite ion chromatography on the enzymatic hydrolysate, and carrying out ultrafiltration to intercept components with the molecular weight of less than 3kDa, so as to obtain the salmon nasal cartilage extract. The extract can significantly improve the multiplication capacity of embryo osteogenesis cell strains, can improve the bone mineral density value of shin bones of SD rats, has wide application prospects in the fields of food, health care products and medicines, and is especially suitable for development of bone health related products.

The utility model discloses a micro-thread implant, which relates to the technical field of implants and comprises a cylinder, a rubber sleeve is arranged at the lower end of the cylinder, straight threads are arranged on the outer side of the lower end of the cylinder, and an inner hexagonal groove is arranged on the top surface of the cylinder; according to the utility model, through the matching of the rubber sleeve and the cylinder, the cylinder can conveniently extrude the rubber sleeve, so that a hydroxyapatite material in the rubber sleeve is extruded out, and the fusion efficiency of the cylinder and new tissues is improved; through the cooperation of the rubber sleeve and the hydroxyapatite, gaps around the cylinder can be conveniently filled, and the fusion effect of the cylinder and new tissues is improved; and through the matching of the straight thread and the fine thread groove, the tooth body can be better mounted, and the tooth body mounting effect is improved.

The invention provides a femoral intramedullary nail system, which comprises a medullary cavity registration modeling unit used for performing three-dimensional reconstruction based on a patient preoperative CT or MRI image, automatically extracting femoral medullary cavity boundary, curvature radius and neck-shaft angle parameters, and generating an individualized medullary cavity geometric model; the intramedullary nail customization design unit is used for automatically matching the diameter, curvature and front rake angle of the intramedullary nail according to the medullary cavity model, ensuring that the gap between the outer diameter of the intramedullary nail and the inner diameter of the medullary cavity is less than or equal to 0.2 mm, and designing a radial limiting rib at the near end of the intramedullary nail to form multi-point contact support; according to the anti-swing matching structure, the head of the intramedullary nail adopts a double-spherical-surface-conical composite matching interface; according to the technical scheme, the intramedullary nail structure customization and surface hydroxyapatite gradient coating deposition are achieved through the metal 3D printing technology, continuous elastic modulus transition is formed at the near end and the far end of the intramedullary nail, and the fixing stability is remarkably improved, and the pendulum effect is restrained.

The invention relates to an enamel bionic dental ceramic repair material for indirect repair as well as a preparation method and application of the enamel bionic dental ceramic repair material, firstly, an ultra-long hydroxyapatite nanowire is synthesized, or the ultra-long hydroxyapatite nanowire is subjected to silicon dioxide or silicon dioxide-zirconium oxide coating modification, and a nano-scale crystal structure form of enamel is simulated; secondly, coupling the nanowires by utilizing amphiphilic molecules gamma-methacryloxy propyl trimethoxy silane or 10-methacryloxy decyl phosphoric acid dihydrogen acid, and inducing the nanowires to be compactly and parallelly arranged, so as to form an enamel-like micron-sized glaze column structure. And then, immersing the nanowire aggregate with the glaze-column-like structure into resin monomer liquid, and realizing ordered and crossed macroscopic arrangement of the glaze-column-like structure under the action of centrifugal strong shearing force. Finally, excessive organic matrixes are removed, the material is compact and solidified under the high-pressure condition of cold sintering, efficient and large-scale enamel-like block construction is achieved, and the material is applied to indirect repair of oral clinical tooth defects.

The application provides a preparation method of a multifunctional toothpaste HA material, and under the premise of taking double-stage hydroxyapatite as a main efficacy component of the toothpaste, the toothpaste shows excellent properties in terms of anti-cariogenic bacteria performance, bacteriostatic performance and promotion of enamel remineralization, and under the condition of taking an ionic liquid+water as an electrolyte, the electrochemical preparation of the double-stage hydroxyapatite also has the characteristics of simple process, high cost performance, non-toxicity, no environmental pollution and convenience for industrialization.

Disclosed herein are oral care compositions comprising hydroxyapatite and hydroxyethylcellulose as well as methods of reducing or inhibiting enamel erosion, repairing enamel erosion damage, and / or increasing enamel microcrack resistance using these compositions.

This invention provides a bone regeneration formula based on collagen synergy and its preparation method. The formula uses low-molecular-weight collagen peptides as organic templates and forms hydroxyapatite-like nanostructures through ion-induced mineralization, achieving a tight organic-inorganic interface. The formula can regulate osteoblast differentiation and inhibit osteoclast activity, thereby improving bone density and bone tissue regeneration capacity. The preparation process adopts a low-temperature enzymatic hydrolysis and biomimetic mineralization coupling process to maintain the stability of the active structure. Experimental results show that the formula is superior to conventional formulas in terms of molecular expression, mineralization capacity, and bone metabolism regulation.

The application discloses a kind of micelles LYTAC engineering biomimetic titanium implants for promoting bone regeneration and its preparation method and application, belong to biomimetic medical instrument technical field.The micelles LYTAC engineering biomimetic titanium implants include titanium matrix, hydroxyapatite coating formed on the surface of the titanium matrix, and multifunctional micelles loaded in the hydroxyapatite coating;The multifunctional micelles include CLP-Apt complex, and the CLP-Apt complex is formed by covalent connection of collagen-like peptide CLP and RANK-CI-M6PR bispecific aptamer Apt through acid-sensitive linker.The application applies LYTAC technology to the surface of titanium implant by constructing HA coating loaded with CLP-Apt micelles.Experiments in vitro and in vivo show that it significantly improves the effect of bone integration under osteoporosis condition, and provides an effective scheme for long-term stability of clinical implant.

The present formulation provides a toothpaste or dentifrice that contains Nano-Hydroxyapatite, Micro-Hydroxyapatite, and Theobromine (with or without Xylitol) to provide a multifaceted approach to prevent caries development, promote caries remineralization (improving the mechanical strength of teeth), and treat tooth hypersensitivity.

The invention discloses a mineralized fiber network composite bone repair aerogel material with early-stage anti-inflammatory and multiple osteogenesis promoting functions and a preparation method of the mineralized fiber network composite bone repair aerogel material. The method comprises the following steps: 1) preparing chitosan fibers by adopting wet spinning, and twisting the chitosan fibers to form fiber bundles; (2) weaving the fiber bundles into fiber webs, and fixing a plurality of fiber webs in a pouring mold in parallel; carrying out surface activation treatment on the fiber by combining a plasma activation process, and forming a Zn < 2 + > doped hydroxyapatite coating on the surface of the fiber by utilizing a hydrothermal method; (3) an alkali-soluble chitosan solution is poured into the pouring mold, and in-situ gelation is carried out; the preparation method comprises the following steps of (1) preparing gel, (2) preparing the gel, (3) preparing the gel, (4) dialyzing the gel, and grafting lipoic acid molecules on the surface of the gel in combination with a surface chemical grafting technology, and (5) introducing a vascular promoting drug into the gel by using an impregnation technology, and freeze-drying to obtain the material. The material has early-stage anti-inflammatory, cell ingrowth promoting and multiple osteogenesis promoting functions, and can be used in the field of bone tissue engineering.

The invention belongs to the field of biomedical engineering materials, and aims to provide a biodegradable bone repair material capable of 3D printing and a preparation method thereof. Biological 3D printing is an emerging subject of additive manufacturing and biomedicine cross fusion, and the tissue engineering scaffold obtained through biological 3D printing has good biocompatibility and excellent biological activity. The degradable bone repair material and 3D printing are combined. Degradable polylactic acid and an inorganic biological material are fused, polycaprolactone-ZnO is subjected to electrostatic spinning to enhance the supporting strength of the material, and meanwhile hydroxyapatite and trace metal elements needed by bone tissue growth are added. In clinical application, the bone repair material plays a supporting role in cell division and new tissue generation. In clinical application, the bone repair material plays a supporting role in cell division and new tissue generation. Along with gradual degradation of the repair material in a living body, the degradation product does not generate host reaction to the living body, and meanwhile, secondary trauma and medical cost caused by the fact that a patient needs to carry out a secondary operation to take out an implant material after bone repair are reduced.

Titanium-based metal implants have brought about revolutionary changes in dental and orthopedic treatments, leading to advances in therapeutic technologies. However, metal-based implants still face unresolved challenges, such as difficulties or delays in osseointegration and inflammation caused by immune responses. To address these challenges, technologies such as plasma treatment of the surface of a metal-based implant or inclusion of bioactive components in implant materials are being researched, but there are problems with fracture and separation from metal implant materials. The present invention relates to a technology for providing osseointegration implant powder for use in a selective laser melting (SLM)-type metal 3D printer. The present invention provides a technology that enables printing by sintering and pulverizing horse bone and mixing the resulting horse bone with a metal powder implant material. Through the above-described configuration, the present invention has addressed the problem in which it was not possible to normally print a 3D implant structure since osseointegration components were burned off during a 3D printing process in an SLM-type metal 3D printer, and enables the printing of 3D structures including osseointegration components in an SLM-type metal 3D printer.