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Magnetic nano porous composite bone tissue engineering support material and preparation method thereof

A technology of bone tissue engineering and scaffold materials, applied in the field of biomedical composite materials, can solve the problems that cannot meet the requirements of artificial bone, collagen and hydroxyapatite cannot be used as structural materials, etc., to improve biomechanical properties and facilitate adhesion Adhesive growth, vascularization, and proliferation-promoting effects

Active Publication Date: 2014-01-01
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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Problems solved by technology

However, because the bone itself is a natural nanocomposite material with high toughness and hardness, it is mainly composed of nanoscale sheet-like hydroxyapatite crystals dispersed in the bone collagen skeleton, and bone collagen and hydroxyapatite themselves are both It cannot be used as a structural material, so the artificial bone with Nano-HA as a single component still cannot meet the requirements of an ideal artificial bone

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  • Magnetic nano porous composite bone tissue engineering support material and preparation method thereof
  • Magnetic nano porous composite bone tissue engineering support material and preparation method thereof

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Embodiment Construction

[0027] Preferred specific embodiments of the present invention are provided below to help further illustrate the present invention, but the protection scope of the present invention is not limited to these examples.

[0028] The technical scheme of the preparation method of the magnetic nanoporous composite bone tissue engineering scaffold material in this embodiment is as follows:

[0029] 1. Synthesis of Nano-HA by sol-flocculation method.

[0030] 2. PLLA was synthesized by ring-opening polymerization.

[0031] 3. The magnetic nanoporous composite scaffold material was synthesized by low temperature rapid prototyping technology.

[0032] In the above preparation method, the synthesis method of the Nano-HA is as follows:

[0033] The aqueous solution of calcium nitrate and ammonium phosphate is chemically synthesized. During the synthesis process, ammonia water is added to adjust the pH value of the solution to 8-13, a dispersant is added, stirred to make the precipitation...

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Abstract

The invention relates to biologic medical composite materials, in particular to a magnetic nano porous composite bone tissue engineering support material and a preparation method thereof. The support material is formed by compounding nano hydroxy-apatite (HA), polylactic acid (PLLA) and magnetic nano particles. By utilizing a low-temperature quick shaping technique, the Nano-HA, the PLLA and the magnetic nano particle Fe2O3 are compounded to prepare a three-dimensional porous Nano-HA / PLLA / Fe2O3 artificial bone, and the three-dimensional porous magnetic nano artificial bone support material integrates the advantages of the Nano-HA, the PLLA and the Fe2O3, is improved in flexibility and biodegradability on the basis of good bone conductibility and biocompatibility, is improved in biomechanical performance, further facilitates the adhesion growth and vascularization of osteocytes, certainly improves the healing speed and effect of a transplanted artificial bone for a bone defect position, and is an ideal novel nano composite artificial bone material.

Description

technical field [0001] The invention relates to biomedical composite materials, in particular to a magnetic nanoporous composite bone tissue engineering scaffold material and a preparation method thereof. Background technique [0002] The research and development of bone tissue engineering provides a new idea for the repair and treatment of clinical bone defects, and gradually arouses the interest of researchers. Among them, the three-dimensional porous scaffold material is an important basis for bone tissue engineering. It not only acts as a support to maintain the shape of the original tissue, but also acts as a template, providing a place for cells to lodge, grow, differentiate and proliferate, thereby Guides the regeneration of damaged tissue and controls the structure of the regenerated tissue. However, the research and application of bone tissue engineering scaffolds still face many problems, such as uncontrollable degradation of materials in vivo, low cell reproducti...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/02A61L27/18A61L27/56A61L27/50
Inventor 王大平黄江鸿熊建义朱伟民刘建全尤微段莉张巨峰陈洁琳
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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