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138results about How to "Promote vascularization" patented technology
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Reusable analyte sensor site and method of using the same
A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.
Owner:MEDTRONIC MIMIMED INC
Biologic Barrier for Implants That Pass Through Mucosal or Cutaneous Tissue
InactiveUS20090036908A1High degreePromote tissue ingrowthDental implantsBone implantProsthesisBiomedical engineering
Apparatus is described for creating a direct mechanical connection between skeletal bone and a prosthetic device located outside of the body. The apparatus provides a means for creating an effective biologic seal to prevent the transmission of microbiologic particles into the body.
Owner:TRIMANUS MEDICAL
Modular intramedullary nail
InactiveUS20050273103A1Improve biomechanical stabilityPromote vascularizationInternal osteosythesisJoint implantsDistal portionIliac screw
An intramedullary nail, comprises a proximal portion, a middle portion and a distal portion. The proximal portion has a longitudinal slot and the distal portion has at least one transversal bore. The proximal portion has a longitudinal axis and a longitudinal bore extending over the longitudinal extension of the slot in the distal direction. The longitudinal bore has an internal thread. An insert which is intended to be inserted in the longitudinal bore. The insert comprises a guiding bore in the form of a slot which is intended to receive fixing elements. The alignment of the guiding bore of said insert is transverse with respect to the longitudinal axis of the proximal portion. The insert has a compression screw adapted to be screwed into said internal thread of the longitudinal bore of the proximal portion to move a fixing element in the direction of the longitudinal axis of the intramedullary nail.
Owner:STRYKER EURO OPERATIONS HLDG LLC
Method for performing three-dimensional printing on biological ceramic bracket based on light-cured molding, and application
ActiveCN107296985AIncreased intensityHigh precisionAdditive manufacturing apparatusTissue regenerationThree Dimensional SizeRepair material
Owner:GUANGDONG UNIV OF TECH
Expression vectors and cell lines expressing vascular endothelial growth factor d, and method of treating melanomas
InactiveUS20020127222A1Increase acceptanceGood treatment effectPeptide/protein ingredientsAntibody mimetics/scaffoldsAbnormal tissue growthDisease
This invention relates to expression vectors comprising VEGF-D and its biologically active derivatives, cell lines stably expressing VEGF-D and its biologically active derivatives, and to a method of making a polypeptide using these expression vectors and host cells. The invention also relates to a method for treating and alleviating melanomas or tumors expressing VEGF-D and various diseases.
Owner:VEGENICS PTY LTD
Cardiac progenitor cells
InactiveUS20090081170A1Modulate inflammatory responseReduce scarsBiocidePeptide/protein ingredientsPopulationMammalian heart
The present invention relates to the field of progenitor cells, and in particular to the field of cardiac progenitor cells. More particularly, the present invention pertains to the identification of a population of progenitor cells in the adult mammalian heart that is capable of giving rise to significant levels of de novo cardiomyocytes with the potential to replenish injured muscle post-infarction and / or promote neovascularisation to bring about complete cardiac regeneration. Accordingly, the present invention relates to methods for generating a population of mammalian post-natal epicardium derived cells (EPDCs), populations of EPDCs so generated, and methods of using same.
Owner:UCL INSTITUTE OF CHILD HEALTH
Glucometer comprising an implantable light source
InactiveUS20070004974A1Long-term monitoringPromote vascularizationUltrasonic/sonic/infrasonic diagnosticsMaterial analysis by optical meansAnalyteAcoustic energy
Apparatus for assaying an analyte in a body comprising: at least one light source implanted in the body controllable to illuminate a tissue region in the body with light at at least one wavelength that is absorbed by the analyte and as a result generates photoacoustic waves in the tissue region; at least one acoustic sensing transducer coupled to the body that receives acoustic energy from the photoacoustic waves and generates signals responsive thereto; and a processor that receives the signals and processes them to determine a concentration of the analyte in the illuminated tissue region.
Owner:GLUCON
Method for preparing collagen protein/silica membrane double-layer stent
ActiveCN103961749AImprove mechanical propertiesGood antibacterial effectAbsorbent padsProsthesisWound healingInsertion stent
The invention relates to a method for preparing a collagen protein / silica membrane double-layer stent. According to the invention, a collagen sponge with a porous network structure is prepared through different crosslinking methods, and a layer of silica membrane with different thicknesses is coated on the collagen sponge again, then the collagen protein / silica membrane double-layer stent is prepared. The collagen protein / silica membrane double-layer stent obtained in the invention has a good effect in an application of being used as an artificial skin stent material, and two layers of the material have different functions, namely the outer layer of the silica membrane has higher mechanical strength to be capable of supporting and protecting a wound, and a good gas-liquid permeability performance to be capable of effectively preventing fluid loss, and a moderate density performance to be capable of preventing bacterial infections and providing a moister environment for wound repair; the inner layer of the collagen sponge can effectively promote cell proliferation and differentiation, delay wound contraction and accelerate wound healing.
Owner:无锡贝迪生物工程股份有限公司
Recombinant retroviral vector
InactiveUS6326195B1Promote vascularizationLower the volumeVirusesPeptide/protein ingredientsProviral dnaBiocompatibility
The invention relates to an implant obtained by assembling in vitro various elements in order to form a neo-organ which is introduced preferably in the peritoneal cavity of the recipient. The implant comprises a biocompatible support intended to the biological anchoring of cells; cells having the capacity of expressing and secreting naturally or after recombination a predetermined compound, for example a compound having a therapeutical interest; and a constituent capable of inducing and / or promoting the geling of said cells. The invention also relates to a kit for the preparation of the implant as well as to a new recombinant retroviral vector comprising a provirus DNA sequence modified in that the genes gag, pol and env have been deleted at least partially so as to obtain a proviral DNA capable of replication. The invention also relates to recombinant cells comprising the new retroviral vector.
Owner:INST PASTEUR
Trace element-doped porous calcium carbonate ceramic, and preparation method and application thereof
The invention discloses a trace element-doped porous calcium carbonate ceramic, and a preparation method and application thereof, belonging to the field of medical materials for bone repair. The preparation method disclosed by the invention comprises the following steps: doping Mg, Sr, Zn, Si, Cu and other trace elements in a human body into calcium carbonate through a chemical precipitation method, or doping trace elements into low-temperature phosphate bioglass used as a sintering binder, uniformly mixing the trace element-doped calcium carbonate powder, the glass binder and pore forming agent, then forming, performing isostatic pressing treatment, sintering, and removing the pore forming agent to obtain the trace element-doped porous calcium carbonate ceramic. The trace element-doped porous calcium carbonate ceramic prepared by the invention has high strength and porosity, controllable degradation rate, long-term slow release of the doped trace element ions and favorable bone conductibility and inductivity, and is a novel artificially synthesized bone repair material.
Owner:GUANGZHOU MEDICAL UNIV
Collagen-based dura and preparation method thereof
ActiveCN103263694ABroaden the field of applicationImprove mechanical strengthFilament/thread formingNon-woven fabricsIonElectrospinning
The invention provides a collagen-based dura on the basis of a process-friendly type ion liquid on-site spinning technology, and a preparation method thereof. The preparation method comprises the steps of: dissolving I type collagen by a novel process-friendly solvent system-ion liquid and sodium salt composite system, fully soaking by taking decellularized pig dermis as a substrate through an electrolyte solution, carrying out electrostatic spinning by taking air as a medium, and regulating the pore structure of collagen fibers by adjusting the electrospinning conditions; removing residual ion liquid with a proper eluent, and carrying out freeze-drying, sterilization and packaging to obtain the collagen-based dura. The collagen-based dura has two or more layers of structures: the aperture of collagen fibers at one side close to brain tissue is controlled to be 3mu m and below, and the aperture of collagen fibers at one side far away from brain tissue is controlled to be 20mu m and above. Compared with the traditional solvent spinning, the preparation method is process-friendly, the toxic and side effects are reduced, and the triple-helical structure of the collagen can be furthest retained.
Owner:BEIJING HOTWIRE MEDICAL TECH DEV CO LTD +1
Porous bacterial cellulose skin repair material with density structure and preparation method thereof
InactiveCN102973985AStrong structural continuityGood biocompatibilityMicroorganism based processesFermentationMicrosphereSkin repair
The invention relates to a porous bacterial cellulose skin repair material with a density structure and a preparation method thereof. The porous bacterial cellulose skin repair material with the 'upper dense and lower loose' structure similar to human skin is prepared by controlling the culture condition of bacterial cellulose and adding sustained-release microspheres in the culture process. A loose layer is tightly combined with a dense layer, so that obvious physical layering is avoided, and the structural continuity is good; and gradient changes of the structures are produced in the loose layer and the dense layer, and multiple pores distributed uniformly are formed in the loose layer, so that the upper dense and lower loose gradient structure of the human skin is simulated to the utmost degree. Cells easily enter the material, the healing period of a wound is obviously shortened, and proliferation of healed scars is effectively reduced; and good air permeability and water holding property of the bacterial cellulose are kept, the wound surface can be kept in a wet environment, and healing of the wound surface is facilitated. The forming process is simple, the culture period is short, the preparation process is environment-friendly, simple, convenient and quick, and the preparation cost is low.
Owner:DONGHUA UNIV
Composite material of organic/inorganic multi-phase induction nano-hydroxyapatite
InactiveCN106075590AGood biocompatibilityAchieve nanoscale dispersionTissue regenerationProsthesisPhosphateApatite
The invention discloses a composite material of organic / inorganic multi-phase induction nano-hydroxyapatite. The composite material is characterized in that on the basis of the effect that graphene oxide can enhance adhesion of stem cells, and stem cells are induced to be differentiated into bone cells and adsorb organic and inorganic nanoparticles, chitosan and bovine collagen are adopted as organic matrixes, a graphene oxide water solution is adopted as an inorganic matrix, a soluble calcium salt and a soluble phosphate are adopted as a precursor of inorganic phase nano-hydroxyapatite, a biological mechanism and an in-situ composite preparation technology are adopted, and the composite material of organic / inorganic multi-phase induction nano-hydroxyapatite is prepared bionically. The preparation conditions are mild, the composite material is uniform in pore diameter, the hole forming performance is good, the biocompatibility and biodegradability are good, and the composite material is expected to be the novel composite material for treating osteoporosis.
Owner:FUZHOU UNIV
Antibacterial biological activity stent and preparation method thereof
ActiveCN103007345AFully biologically activeImprove mechanical propertiesProsthesisUltra Low Temperature FreezerCambium
The invention relates to an antibacterial biological activity stent and a preparation method thereof. The method comprises the steps that gelatin microspheres are prepared; porous gelatin microspheres are prepared; gelatin microspheres carried with active factors are obtained; an antibacterial stent is prepared, wherein the preparation of the antibacterial stent comprises the steps that at least one of collagen, chitosan and silk fibroin and nano-silver grains are added to acetic acid or malonic acid to prepare a mixed solution, the mixed solution is poured into a die which is horizontally paved with the solid gelatin microspheres, the die is rapidly placed in an ultra cold refrigerator for freezing treatment, and the die is frozen and dried to obtain the antibacterial stent; and the antibacterial biological activity stent is prepared by the steps that the gelatin microspheres carried with the active factors are placed into normal saline to prepare a suspension liquid, and the suspension liquid is poured into the antibacterial stent to obtain the antibacterial biological activity stent after dried at the room temperature. According to the antibacterial biological activity stent and the preparation method thereof, pure natural polymers are taken as raw materials, the nano-silver grains and the bioactive factors are compounded to prepare the stent, so that the stent has the biological activity and antibacterial capacity, can effectively promote vascularization of cambium and can be used for skin injury healing.
Owner:RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
Vascularized fat depot based on partition and construction method thereof
ActiveCN101492655AMeet individual needsSo as not to damageSkeletal/connective tissue cellsTissue/virus culture apparatusBlood Vessel TissueMicrosphere
The invention relates to a vascularized adipose tissue based on partition and a construction method thereof. The vascularized adipose tissue of the invention imitates the structure of a natural adipose tissue to coat an adipose cell into a microcapsule and realize partition with a vascular tissue; the construction method thereof comprises: 1) construction of an adipose area; 2) preparation of thecomponents of the blood vessel; 3) construction of the vascularized adipose tissue, which comprises the steps as follows: i) a nutrilit sustained-release microspheres and an adipose tocyst are mixed with a host material and used as a main material, a smooth muscle cell is used as a channel material to construct a 3D structure body provided with a through channel; ii) pulsatile in vitro culture iscarried out on the 3D structure body; and perfusion is carried out with the suspension of an endothelial cell to lead the endothelial cell to be adhered to the inner wall of the channel to form the vascular tissue the outer wall of which is the smooth muscle cell and the inner wall of which is the endothelial cell. Based on the construction method of the invention, the adipose tissue which has adipose and blood vessel distributed by partition and graded vascular structures and can exist in a body for a long period can be obtained.
Owner:TSINGHUA UNIV
Medical device with adjustable epidermal tissue ingrowth cuff
Methods and apparatus are disclosed for making and using adjustable epidermal tissue ingrowth cuff and catheter assemblies for transcutaneous placement to provide periodic or continuous external access for medical purposes to an interior body region of a patent who requires such medical treatment over an extended period of time.
Owner:SAAB
Method for manufacturing artificial soft tissue body carried with vascular net flow channel
ActiveCN104027847AMeet structural precision requirementsSolve the problem of growing space restrictionsProsthesisVascular channelVascular structure
The invention provides a method for manufacturing an artificial soft tissue body carried with a vascular net flow channel. The method comprises the following steps of: firstly designing a soft tissue scaffold model with a vascular structure, layering the soft tissue scaffold model one by one at equal distance, and manufacturing photomask plates of various layers; then uniformly mixing a cell and a collagen solution, and injecting a photocuring hydrogel and a photoinitiator to obtain a photocuring composite solution; injecting the photocuring composite solution to a work table, covering with the photomask plates, curing the photocuring composite solution by adopting a surface exposure technology, and then carrying out curing accumulation layer by layer to obtain a photocured hydrogel soft tissue scaffold with the vascular structure; planting vascular endothelial cells to the vascular structure of the photocured hydrogel soft tissue scaffold, wherein the vascular endothelial cells are attached to the surface of a vascular channel; carrying out static culture and dynamic culture in vitro to obtain the artificial soft tissue body carried with the vascular net flow channel. The method provided by the invention can solve the problems of survival of cells inside a large tissue engineering soft tissue scaffold, and soft tissue scaffold vessel network manufacturing and vascularization in the large injury repair of a soft tissue.
Owner:XI AN JIAOTONG UNIV
Low-modulus medical implant porous scaffold structure
Owner:FUJIAN CTRUE MATERIALS TECH
Reusable Infusion Site and Method of Using the Same
InactiveUS20070079836A1Promote vascularizationAvoid stagnationSurgeryEndoradiosondesAnalyteEngineering
A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.
Owner:MEDTRONIC MIMIMED INC
Biomatrix structural containment and fixation systems and methods of use thereof
ActiveUS20050163817A1Improves current therapyShorten recovery timeAntibacterial agentsOrganic active ingredientsActive agentMedicine
The containment and fixation system of the present invention generally includes a biomatix sleeve, biomatrix particles or combinations thereof made of a biomatrix material. The biomatrix material is comprised of one or more biocompatible proteins and one or more biocompatible solvents. The biomatrix material utilized in the sleeve and / or particles may also include one or more pharmacologically active agents like therapeutic biochemicals such as a bone mending biochemical (e.g. hydroxyapatite) or an angiogenic growth factor (e.g. BMP).
Owner:PETVIVO HLDG INC
Calcium magnesium silicate porous ceramic ball ocularprosthesis seat and preparation method thereof
The present invention discloses a calcium magnesium silicate porous ceramic ball ocularprosthesis seat and a preparation method. The calcium magnesium silicate porous ceramic ball ocularprosthesis seat comprises a non-biodegradable calcium magnesium silicate porous ceramic ball ocularprosthesis seat and a degradable calcium magnesium silicate modification layer covering the surface of the pore channel wall, wherein the ocularprosthesis seat has a completely penetrating porous structure, the porosity is 35-85%, the pore channel diameter is 60-800 [mu]m, the ocularprosthesis seat is a porous diopside ceramic ball constructed by using a three-dimensional printing technology, and the pore channel wall is subjected to degradable calcium magnesium silicate gel precursor filling modification and secondary sintering to obtain the product. According to the present invention, after the calcium magnesium silicate porous ceramic ball ocularprosthesis seat is implanted into the eye socket, the neovessel growth is promoted through the bioactivity of the pore channel surface layer calcium magnesium silicate layer so as to achieve the rapid vascularization in the pore channel and avoid the displacement or prolapse of the ocularprosthesis seat; and the calcium-silicon-based ceramic ocularprosthesis seat pore channel wall bioactivity is excellent, and the application value is provided in the reconstruction of the ocular base.
Owner:ZHEJIANG UNIV
Method for preparing heparin collagen/chitosan porous rack of composite angiogenin
The preparation process of porous heparinized collagen / chitosan rack with compounded angiogenin includes the following steps: dissolving ox tendon and chitosan separately in acetic acid solution to compound 0.5-5 % concentration solution, mixing chitosan solution in 5-30 % and ox tendon solution, molding and freeze drying to obtain porous collagen / chitosan rack; vacuum treatment, soaking the porous collagen / chitosan rack inside 2-N-morpholynyl ethane sulfonic acid solution of heparin sodium, treating with 1-ethyl-3-3-(dimethylaminopropyl)-carbonized diimine solution and N-hydroxy batanimide solution, washing, re-freezing to dry and to obtain porous heparinized collagen / chitosan rack; and soaking the porous heparinized collagen / chitosan rack inside angiogenin solution to obtain the porous heparinized collagen / chitosan rack with compounded angiogenin. The prepared rack has proper pore size and porosity and is used as the corium substitute in skin tissue engineering.
Owner:ZHEJIANG UNIV
Bone repair material and preparation method thereof
ActiveCN111888521AAvoid the risk of further fracturesPromote ingrowthAntibacterial agentsPharmaceutical delivery mechanismBiocompatibilityCell growth
The invention discloses a bone repair material as well as a preparation method and application thereof. The bone repair material comprises the following components: magnesium oxide, monocalcium phosphate, sodium dihydrogen phosphate and calcium-deficient hydroxyapatite. The molar ratio of the magnesium oxide to the monocalcium phosphate to a sodium dihydrogen phosphate bone cement powder is 6:1:4,5:1:3 or 3:1:1, and the calcium-deficient hydroxyapatite accounts for 20% of the total mass. A curing liquid of the bone cement is an EGCG aqueous solution, and the concentration is 120 [mu]mol / L. Aloaded drug is deferoxamine. The preparation method of the bone repair material is simple and feasible; and the setting time is suitable, the bone cement has good biocompatibility, osteogenesis and degradability, and can promote adhesion, proliferation and differentiation of osteoblasts, stimulate cell growth and stimulate differentiation of the osteoblasts into the osteoblasts, and the bone repair material can be directly injected into a bone defect part.
Owner:上海禾麦医学科技有限公司
Hydroxyapatite/polyamide composite biological material with nanofiber cellular structure on surface and preparing method thereof
InactiveCN104815355AHigh bone repair performancePromotes Adhesive GrowthProsthesisAlcoholElectrospinning
The invention provides a hydroxyapatite / polyamide composite biological material with a nanofiber cellular structure on the surface. The material is composed of a molding base body and a nanofiber layer which covers the surface of the molding base body and is combined with the molding base body integrally; nanofibers in the nanofiber layer are staggered to form the cellular structure, and the molding base body and the nanofiber layer are the hydroxyapatite / polyamide composite biological material. A preparing method includes the following steps: the hydroxyapatite / polyamide composite biological material and calcium chloride are dissolved into absolute ethyl alcohol to form a spinning solution; the molding base body is arranged on a receiving screen, and the spinning solution is coated on the molding base body in a spinning mode with an electrostatic spinning method, and the hydroxyapatite / polyamide composite biological material is obtained. By means of the hydroxyapatite / polyamide composite biological material, adherence growth of cells and tissues are facilitated, vascularization is easily achieved after the hydroxyapatite / polyamide composite biological material is implanted, and the combination performance between the hydroxyapatite / polyamide composite biological material and the bone tissues is good.
Owner:SICHUAN UNIV
In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
ActiveUS20210251742A1Increase surface areaOvercome disadvantagesMammary implantsTissue regenerationHuman bodyEngineering
Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.
Owner:BARD SHANNON LTD
Amnion innate stem cell carried frozen active amnion particle and conditioned medium and application thereof
ActiveCN105018417AAvoid spreadingRetain activityDead animal preservationEmbryonic cellsDiseaseCuticle
The invention relates to the technical field of tissue engineering and medical wound repairing, in particular to an amnion innate stem cell carried frozen active amnion particle and a conditioned medium and application thereof. Discarded fresh amnions are prepared into particles and then frozen into liquid nitrogen by means of serum-free stem cell freezing liquid; thus, complete matrix components of amnion are maintained while amnion epithelial cell activity is maintained for a long time, and further, disease transmission is avoided effectively. The conditioned medium which is prepared and collected by means of the frozen active amnion particles can promote chemotaxis and migration of human epidermal cells, fibroblast and endothelial cells effectively. In terms of zoografting, wound healing can be improved by multiple ways of regulating inflammatory reaction, promoting vascularization, quickening epithelization and the like through the active amnion particles; further, the amnion matrix can be directly used as a dermis equivalent to induce dermal regeneration so as to improve wound healing quality remarkably. The amnion innate stem cell carried frozen active amnion particle and the conditioned medium thereof can provide simple but effective ways for wound repairing.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Multiphase hybrid micro-nano structure magnetic composite material and preparation method thereof
InactiveCN106075589AImprove adhesionPromote growthTissue regenerationProsthesisPhosphateBiocompatibility Testing
The invention discloses a multiphase hybrid micro-nano structure magnetic composite material. By serving chitosan and bovine collagen as organic matrixes, dissolvable calcium salt and dissolvable phosphate as precursors of inorganic phase nano-hydroxyapatite and serving dissolvable molysite and dissolvable ferrite as precursors of inorganic phase paramagnetic nano ferroferric oxide, the multiphase hybrid micro-nano structure magnetic composite material is prepared through a biological mechanism and an in-situ synthesis preparation technology. Preparation conditions are mild, and the obtained composite material is uniform in pore diameter and good in pore-forming performance, biocompatibility and biodegradability and is expected to become a novel composite material for repairing bone tumors.
Owner:FUZHOU UNIV
In Vivo Tissue Engineering Devices, Methods and Regenerative and Cellular Medicine Employing Scaffolds Made of Absorbable Material
ActiveUS20200268503A1Promote vascularizationAvoid poolingMammary implantsCosmetic implantsHuman bodyOrgan function
Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.
Owner:BARD SHANNON LTD
Regeneration material of dermis substitution for tissue engineering skin for loading rhGM-CSF and preparation method thereof
InactiveCN102038976AGood biocompatibilityGood regenerative repair effectProsthesisVascularizesInfection risk
The invention relates to a regeneration material of artificial dermis substitution and a preparation method thereof. In the regeneration material of a dermis substitution for tissue engineering skin for loading rhGM-CSF, the regeneration material is formed by a heparinizing collagen-chitosan bracket loading the rhGM-CSF solution. The invention further discloses a preparation method of the regeneration material. The invention provides an artificial dermis substitution with good performance for curing the whole skin coloboma of trauma, burning, chronic skin ulcer, thereby being capable of remarkably quickening the vascularization process of the regeneration material of artificial dermis substitution, decreasing the infection risk, promoting the healing of the surface of a wound and reducing the hyperplasia of scar, and thus easing the pain of patients. The invention can be widely applied for the aspects of trauma, burning, surgery reshaping, and the like. The preparing method is simple, the source of the material is wide, the production efficiency is high, and the invention is suitable for industrial production.
Owner:ZHEJIANG UNIV
Dual-phase magnetic nano-composite scaffold material and preparation method thereof
InactiveCN107875443APromote cell adhesionLow toxicityTissue regenerationProsthesisChemistryBiocompatibility Testing
The invention discloses a dual-phase magnetic nano-composite scaffold material. The dual-phase magnetic nano-composite scaffold material is prepared by compositing a cartilago phase with a bone phase,wherein the cartilago phase contains polylactic acid and a natural polymer compound; and the bone phase contains polylactic acid, nano-hydroxyapatite and magnetic nanoparticles. The invention furtherdiscloses a preparation method of the dual-phase magnetic nano-composite scaffold material. The three-dimensional dual-phase magnetic nano-composite scaffold material is prepared from polylactic acid, the natural polymer compound, nano-hydroxyapatite and the magnetic nano particles by virtue of a low-temperature rapid forming technique and is integrated with the advantages of the four materials,is capable of promoting the adhesion and proliferation of cells, reducing the toxicity of degradation products and improving the biomechanical properties based on good osteoconduction and biocompatibility and is relatively beneficial to the adhesion growth and vascularization of solid cells, and the speed and effect of the coalescence between artificial cartilages transplanted at bone defect partsof a joint cartilage and a subchondral bone and the bones are greatly increased and improved.
Owner:THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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