84 results about "Joint cartilage" patented technology

The invention discloses a knee joint cartilage medical image segmentation method based on a double-flow space attention neural network, and belongs to the technical field of medical image analysis. In order to solve the problem of inaccurate segmentation of a cartilage boundary fuzzy region in an existing knee joint cartilage medical image segmentation method, one branch of a double-flow encoder module adopts deformable convolution combined with a self-attention mechanism to extract features, and the other branch of the double-flow encoder module extracts stable multi-scale features through a multi-layer convolution module; fusing the double-flow features through a double-branch information dynamic aggregation module; on the basis of shape priori knowledge, performing adaptive fusion on anatomical priori knowledge and the feature map through a space attention mechanism; and the cross-branch interaction enhancement module adopts an improved Inception structure to recover image details layer by layer, and finally knee joint cartilage medical image segmentation is realized.

The invention discloses a cyclic IL-10mRNA nano preparation as well as a preparation method and application thereof, and belongs to the technical field of biology. The annular IL-10mRNA nano preparation is prepared by the following method: 1, synthesizing chemically modified annular IL-10mRNA in vitro, and 2, preparing the annular IL-10mRNA nano preparation capable of being delivered in vivo by a self-assembly method. The annular IL-10mRNA can regulate immune cells in synovial membranes of articular cavities and inhibit articular cartilage injury, so that the effect of treating joint inflammatory diseases is achieved. The application has the advantages that the annular IL-10mRNA is successfully delivered into the joint cavity with the joint inflammatory disease through the nano system, and the inflammation environment in the joint cavity with the joint inflammatory disease is adjusted, so that the development of inflammation is inhibited; the cyclic IL-10 promotes cartilage repair so as to improve the disease progress of joint inflammatory diseases.

The invention discloses a Zhejiang anoectochilus roxburghii polysaccharide and application thereof in preparation of cartilage injury repair medicine.The Zhejiang anoectochilus roxburghii polysaccharide is characterized in that a crude polysaccharide AZJP is extracted from the Zhejiang anoectochilus roxburghii polysaccharide through a hot water extraction method, an anion exchange column DEAE-celluse-52 and a gel permeation chromatographic column Sephadex G-200 are used for separating the AZJP, and the Zhejiang anoectochilus roxburghii homogeneous polysaccharides AZJP-1a, AZJP-2a, AZJP-2b and AZJP-2c are obtained; measuring UV (ultraviolet), IR (infrared), molecular weight, monosaccharide composition, methylated sugar residues, NMR (nuclear magnetic resonance) signals, triple helix structures, SEM (scanning electron microscope) and AFM (atomic force microscopy) surface microstructures and cartilage repair activity; the four homogeneous polysaccharides have remarkable cartilage repair activity on transgenic zebrafish, are superior to a positive drug alendronate sodium, and have application prospects in development of drugs for treating osteoarticular cartilage injuries.

The poultry claw and tarsal articular cartilage removing device comprises a first connecting block, a second connecting block, a scraping block, a limiting block and an adjusting rod, the scraping block is arranged at the front end of the first connecting block, and the rear end of the first connecting block is connected with the upper end of the second connecting block; the adjusting rod is arranged below the first connecting block and is adjustably connected with the first connecting block or the second connecting block, and the limiting block is arranged at the front end of the adjusting rod. According to the cartilage deboning device, the distance between the limiting block and the scraping block can be adjusted through the adjusting rod, so that the cartilage deboning device can adapt to poultry claws of different specifications, the cartilage deboning efficiency can be effectively improved, and food material waste caused by skin and meat involved by articular cartilage in the deboning process is avoided.

The invention belongs to the technical field of biological composite materials, and particularly relates to a CE-SKP / CPH / P2G3 three-layer composite scaffold, a preparation method and application. The CE-SKP / CPH / P2G3 three-layer composite scaffold is characterized in that CPH hydrogel is placed under a CE-SKP composite scaffold system, a P2G3 nanofiber membrane is placed under the CPH hydrogel, a calcified cartilage layer of a physiological structure is simulated, relative independence of a cartilage repair microenvironment is kept, and mineralization of newborn cartilage cells is induced, so that the calcified cartilage layer of the physiological structure is formed; wherein the CE-SKP composite scaffold system is a seed cell-free composite scaffold system which is constructed by adsorbing self-assembled polypeptide nanofiber hydrogel Ac-(RADA) 4-CONH2 / Ac-(RADA) 4GGSKPPGTSS-CONH2 (RAD / SKP) to a natural cartilage extracellular matrix (ECM), and the composite scaffold system is a seed cell-free composite scaffold system which is constructed by adsorbing the self-assembled polypeptide nanofiber hydrogel Ac-(RADA) 4-CONH2 / Ac-(RADA) 4GGSKPPGTSS-CONH2 (RAD / SKP) to the natural cartilage extracellular matrix (ECM). The CE-SKP / CPH / P2G3 three-layer composite scaffold utilizes the three-layer composite structure to solve the technical problems that in the prior art, a cartilage layer and a calcified cartilage layer in a physiological structure cannot be well simulated, and independence of a repairing microenvironment cannot be kept, joint repairing of the cartilage layer and the calcified cartilage layer is achieved, and a better articular cartilage full-thickness defect repairing effect is achieved.

The invention discloses a knee joint cartilage grading model training method and device and a knee joint cartilage grading method and device. The method comprises the steps that a first image training set of knee joint cartilage is acquired; performing hierarchical labeling and data preprocessing on the first image training set to obtain a second image training set; inputting the second image training set into a variational auto-encoder model, and performing redundancy elimination and adaptive decoupling on the second image training set to obtain a third image training set; compressing the third image training set to obtain a first low-dimensional representation; decoding the first low-dimensional representation to obtain a fourth image training set; obtaining a total loss function according to the first image training set and the fourth image training set; according to the total loss function, the gradient of the initial parameters of the variational auto-encoder model is obtained, the initial parameters are updated through a gradient descent method, and a knee joint cartilage grading model is obtained. The method can improve the accuracy of knee joint cartilage grading, and can be widely applied to the technical field of image processing.

This invention relates to the treatment of osteoarthritic pain, or pain associated with osteoarthritis, and particularly for LINK_TSG6 polypeptide for use in the treatment of osteoarthritic pain. Osteoarthritis is caused by the deterioration of cartilage in joints and is characterised by pain and a loss of mobility in the affected joints. Osteoarthritic pain results from multiple factors including bone marrow lesions, sub-articular bone attrition, synovitis, effusion and innervation of usually insensitive tissues. LINK_TSG6 is a short recombinant peptide comprising the LINK module of human TSG-6.

Whole blood is mixed with one or more coagulators to produce coagulated blood which is then introduced into a site of bone or joint damage or disease and allowed to coagulate at the site. The aim is to promote healing or amelioration of a disease, disorder or lesion at the site, such as healing and regeneration-6623 of damaged bone, damaged joint, cartilage lesion, and the like.

The application provides a composite gel product which is designed according to the main components of articular cartilage based on the bionics principle and is made of biological cellulose (BC), polyvinyl alcohol (PVA), an anionic surfactant and chitosan, has mechanical properties, friction characteristics close to articular cartilage and good biocompatibility and degradability and can be used for preparing a cartilage joint injury repair material.

The invention discloses a multifunctional bone peptide compound and application thereof in prevention and treatment of osteoporotic osteoarthritis, and relates to the technical field of bone peptides. The multifunctional bone peptide compound is prepared from the following raw materials: giant salamander bone meal, bovine bone articular cartilage powder, bovine bone meal, sturgeon bone meal, oyster bone meal, deer-horn glue powder, calcium chloride and fructo-oligosaccharide. According to the multifunctional bone peptide compound disclosed by the invention, the composite aggregate is subjected to enzymolysis step by step by using the compound enzyme, the bone peptide and calcium ions are compounded through a chelation reaction, the absorbability of calcium is improved, one part of the bone peptide in the composite bone peptide has a function of promoting osteoblast activity, and the other part of the bone peptide possibly has a function of inhibiting overactivity of osteoclasts; part of the bone peptide has an anti-inflammatory effect, can regulate bone metabolism, repair articular cartilage and relieve inflammatory response, and can improve the effect of the bone peptide product in the aspects of preventing and treating osteoporosis, osteoarthritis and other diseases.

A drill-less method of stabilizing a sacroiliac joint using a multimodal abrading device to create a rich environment for bony fusion. The unique decortication instrument includes an integral slap hammer assembly joined with a rasp-box osteotome tooling head to simultaneously remove cartilage from the joint while preparing the sacrum and ilium down to bleeding bone. Subsequent to joint preparation, an implant with a large bone graft window may be implanted into the prepared SI joint through a specially designed access cannula.

Devices and methods for treating joint degeneration (e.g., intervertebral disc degeneration) are provided. An example method may comprise: (1) advancing a tip of an introducer needle into a nucleus pulpous of an intervertebral disc; (2) with the tip of the introducer needle in the nucleus pulpous, maneuvering, out of the tip of the introducer needle, a tip of a flexible needle into a region of a cartilaginous endplate (CEP) of the intervertebral disc; and (3) delivering, from an aperture of the flexible needle, therapeutic to the region of the CEP.

The application discloses a functional composition for improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component; the first active component comprises elastin peptide, haematococcus pluvialis and ergothioneine; and the second active component comprises one or more of houttuynia cordata and non-denatured type II collagen. The application realizes the protection effect on joint, cartilage and bone health by scientific matching of the components and synergistically improving the glycosaminoglycan level in chondrocytes and the osteocalcin level in osteoblasts. Meanwhile, the components in the functional composition for improving bone and joint health are natural and have good biocompatibility, and have no obvious side effects, so that the application provides a kind of drug or a substitute for the treatment and prevention of bone diseases.

The application discloses a joint cartilage stress dynamic monitoring system based on flexible sensing and AI and belongs to the technical field of medical health monitoring.The application solves the problem that the prior art can only measure single-point pressure or strain and cannot obtain full-field three-dimensional stress distribution of a cartilage contact surface, and the system function stops at monitoring and does not form a monitoring-to-warning closed loop, quantifies uncertainty through a Bayesian neural network, provides a reliable basis for clinical decision-making, combines multidimensional biomechanical characteristics and an attention mechanism, accurately focuses on a stress key area, significantly improves the precision and individualization level of joint cartilage health evaluation, helps early detection and prevention of injury, classifies stress abnormalities, implements accurate early warning, and formulates an individualized treatment scheme according to uncertainty results and cartilage health indexes, and customizes a rehabilitation training plan according to user conditions, and improves the scientific nature of joint injury prevention and rehabilitation.

The invention relates to the technical field of biology, and particularly discloses a composition and application thereof in improving articular cartilage health. The composition comprises sodium hyaluronate, colostrum basic protein and N-acetylglucosamine, wherein the mass ratio of the sodium hyaluronate to the colostrum basic protein to the N-acetylglucosamine is (1-2): (1-2): (1-8). The composition disclosed by the invention can be used for increasing the bone mineral density, increasing the number of osteoblasts, promoting cartilage growth and increasing the content of II-type collagen in an animal body, so that the bone joint function can be effectively improved, and a new method is provided for joint maintenance.

The invention discloses a functional composition capable of improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component, the first active component is prepared from elastin peptide, haematococcus pluvialis and ergothioneine; the second active component is prepared from one or more of herba houttuyniae and non-denatured type II collagen. Through scientific compatibility of all the components, the levels of glycosaminoglycan in chondrocytes and osteocalcin in osteoblasts are synergistically improved, and the protection effect on joint, cartilage and skeleton health is achieved. Meanwhile, a plurality of components in the functional composition capable of improving the health of the bones and the joints are natural in source, good in biocompatibility and free of obvious side effects, and a medicine or an alternative scheme thereof is provided for treatment and prevention of the bone diseases.

The invention relates to the technical field of biological pharmacy, and particularly discloses targeting drug-loaded nanoparticles for treating rheumatoid arthritis (RA) as well as a preparation method and application thereof, and the technical key points are as follows: on the basis that a GLP-1R agonist (such as liraglutide) is proved to be capable of effectively relieving rheumatoid arthritis symptoms, the targeting drug-loaded nanoparticles can be used for treating rheumatoid arthritis; gLP-1RA is wrapped by the silk fibroin nanoparticles to prepare the drug-loaded nanoparticles, and the drug-loaded nanoparticles can effectively improve the stability of GLP-1RA, prolong retention time in vivo and improve the curative effect of the drug; the drug-loaded nanoparticles and the type II collagen targeting peptide (WYRGRL) are crosslinked, so that the drug-loaded nanoparticles target the articular cartilage, the drug is gathered on the articular cartilage to be attached, the local concentration of the drug and the availability of the drug are further improved, and the curative effect of inhibiting the progress of RA is further enhanced; for lesion facet joints in RA, the treatment scheme of micro-needle administration can realize slow release of drugs, and the micro-needle is convenient to use and is suitable for patients to use at home.

The application provides a kind of joint microenvironment regulating hydrogel and application, belong to medical and biomedical material technical field, raw material includes methacrylated aldehyde-based hyaluronic acid, RGDS grafted aldehyde-based hyaluronic acid, epsilon-polylysine and GW1100, the above raw materials are added into buffer solution and mixed to obtain gel precursor solution, the gel precursor solution is photocured to obtain the joint microenvironment regulating hydrogel.The raw material of the joint microenvironment regulating hydrogel is widely sourced, green and environmentally friendly, low cost, the preparation method of the hydrogel is simple, and there is no organic solvent residue.The experimental results prove that the joint microenvironment regulating hydrogel has good biocompatibility and biological activity, and has good application prospect in joint cartilage repair and tissue regeneration.

The invention relates to the technical field of cell preparations, in particular to a method for rapidly evaluating the repairing function of cartilage cells on cartilage injury at low cost, which comprises the following steps: constructing a cartilage injury model by adopting pig knee and femoral joint cartilage tissues, inoculating cell spheres formed by the to-be-evaluated cartilage cells to an injury part of the cartilage injury model, and evaluating the cartilage injury part of the cartilage injury model. And transplanting the cartilage cells into an experimental animal body, and evaluating the repair function of the cartilage cells according to the repair condition of the cartilage injury model. The method provides a systematic scheme for evaluating the repairing function of the cartilage cells, has the advantages of simplicity in operation, short time consumption, low cost, high stability and the like, and provides an effective method for evaluating the functions of the cartilage cells and screening and evaluating the functions of cells such as induced pluripotent stem cells with cartilage injury repairing potential; the method has a good application prospect in development of cell preparations for cartilage injury repair.

The utility model relates to the technical field of medical instruments, in particular to a shoulder arthroscopy thread catcher which comprises a handle, a sliding rod, a metal tube and an elastic thread, an axis hole is axially formed in a body of the handle, a groove is formed in the side face of the body, and the groove is communicated with the axis hole; the sliding rod is inserted into the axis hole in a sliding manner; the metal tube comprises a straight tube section and a bent tube section, a tube cavity of the straight tube section and a tube cavity of the bent tube section are communicated, a puncture tip is arranged at the end of the bent tube section, a wire outlet communicated with the tube cavity is formed in the side face close to the puncture tip, the metal tube is connected with the end face of the handle through the straight tube section, and the tube cavity of the straight tube section is communicated with the axis hole; one end of the elastic silk thread is close to the puncture tip and connected to the bent pipe section, and the other end of the elastic silk thread penetrates through the thread outlet and a pipe cavity of the metal pipe and then is connected with one end of the sliding rod. The utility model has the advantages of simple structure, low cost and more accurate and quicker line grasping, can reduce the frequency of replacing an observation approach, and is beneficial to shortening the operation time and avoiding articular cartilage injury.

The application discloses a kind of for repairing cartilage decellularized cartilage matrix support and apoptotic corpuscle composition and its preparation method, composition includes: microporous support, support includes decellularized cartilage outer matrix and crosslinked organic polymer;Apoptotic corpuscle, apoptotic corpuscle exists in microporous support;Wherein, based on the volume 3.14mm 3 Microporous support, 0.01-0.02ug of apoptotic corpuscle is included.The combined support of the application can improve the activity of apoptotic corpuscle, prolong the action time of apoptotic corpuscle, achieve the effect of slow release, also can regulate joint cavity microenvironment, effectively promote joint cartilage repair, improve the repair effect of loss cartilage, avoid the security risks brought by traditional exogenous cell transplantation.

The invention discloses a hip joint cartilage non-uniform multi-section feature three-dimensional reconstruction method, and belongs to the field of medical image three-dimensional digital modeling and orthopedic biomechanical technology research. According to the method, hip joint dysplasia is taken as a research object, and boundary segmentation and reconstruction of a three-dimensional geometric model of bone tissue are carried out through CT (Computed Tomography); based on a nuclear magnetic resonance image and an anatomical structure, computer-aided software and a curve fitting method are utilized to reconstruct a high-precision hip joint cartilage three-dimensional geometric model with inner and outer contours and non-uniform thickness, and finally a hip joint-cartilage three-dimensional model is constructed in an origin registration mode. According to the method, the multi-section feature three-dimensional model of the hip joint cartilage can be accurately and efficiently reconstructed, irregular curved surfaces of the cartilage reconstruction model are effectively reduced, and finite element mesh division and surface contact calculation of the hip joint are facilitated; and a high-precision cartilage three-dimensional digital model reference is provided for clinical diagnosis and treatment, rehabilitation, prosthesis design and biomechanical analysis of hip joint diseases.

The invention relates to the technical field of machine learning, in particular to a knee osteoarthritis assessment method based on machine learning, which comprises the following steps: acquiring knee joint T1 and T2 weighted images of a patient with knee osteoarthritis; manually segmenting the knee joint cartilage in the T1 weighted image and measuring the volume of the knee joint cartilage; cutting the T2 weighted image to obtain a meniscus image, manually segmenting the meniscus image to obtain annotation data, and constructing an image data set; training a meniscus automatic segmentation model, and segmenting the meniscus in the meniscus image; carrying out three-classification on meniscus pixels of the middle five layers of the meniscus image, and calculating a meniscus space specificity signal index; the performance of the meniscus space specific signal index in diagnosis of knee osteoarthritis is systematically evaluated. According to the knee joint meniscus damage diagnosis method, the knee joint T1 and T2 weighted images of a patient with knee osteoarthritis are collected, the meniscus automatic segmentation model and a meniscus space specificity signal index calculation method are applied, the damage condition of the knee joint meniscus is accurately evaluated, and knee osteoarthritis diagnosis is achieved. The process can provide a reliable diagnosis basis for orthopedists, so that clinical diagnosis of knee osteoarthritis is effectively assisted.

Disclosed is a unit for reaming of the surface of joint cartilage and of periarticular bone of an acetabulum and femoral head, used in orthopaedical surgery, being used as equipment to prepare the surface of cartilage and periarticular bone for endoprosthesis implantation. The unit is has at least two burrs with a slanting end of the cutting blade and an arc shape, ending with a ball-shaped pivot, placed in the guides of a matrix, whereas each of the burrs is placed in a channel of a shaped body, whereas the body is connected by a joint with the unit's drive mechanism.

This invention relates to a temperature-induced self-assembly cartilage repair gel, its preparation method, and its applications, belonging to the field of biomedical materials technology. The gel is prepared by dissolving recombinant type II humanized collagen and sodium hyaluronate in a mass ratio of 0.7:1 to 7:1 in 0.01M phosphate buffer and allowing it to stand at 4±2℃ for at least 3 days to complete self-assembly. Under specific ionic strength and pH conditions, the low temperature of 4±2℃ drives the recombinant type II humanized collagen and sodium hyaluronate to form an ordered interpenetrating network structure through non-covalent supramolecular interactions, endowing the gel with excellent mechanical properties and anti-enzymatic stability, while significantly promoting the proliferation, migration, and chondrogenic differentiation of bone marrow mesenchymal stem cells. A rat cartilage defect model confirms the gel's excellent in vivo repair effect. The gel can be easily extruded through a 22G-25G injection needle and is suitable for minimally invasive injection treatment of joint cartilage defects.

The invention discloses an articular cartilage stress dynamic monitoring system based on flexible sensing and AI, and belongs to the technical field of medical health monitoring. According to the invention, the problems that only single-point pressure or strain can be measured and full-field and three-dimensional stress distribution of a cartilage contact surface cannot be obtained in the prior art are solved; according to the method, the problems that the system functions stop monitoring and a closed loop from monitoring to early warning is not formed are solved, the uncertainty is quantified through the Bayesian neural network, and a reliable basis is provided for clinical decision making; by combining multi-dimensional biomechanical characteristics and an attention mechanism, a stress key area is accurately focused, the accuracy and individuation level of articular cartilage health assessment are remarkably improved, and early discovery and prevention of injuries are assisted; meanwhile, stress abnormity is graded, accurate early warning is implemented, and a personalized treatment scheme is formulated according to an uncertainty result and cartilage health indexes; a rehabilitation training plan is customized according to user conditions, and the scientificity of joint injury prevention and rehabilitation is improved.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to dexamethasone single-phase zero-order release sustained-release microspheres as well as a preparation method and application thereof. The dexamethasone sustained-release microspheres are prepared by an emulsification-solvent evaporation method, the release platform phase of the microspheres is improved by adding a release accelerator, and finally the dexamethasone sustained-release microspheres with a single-phase zero-order release behavior are obtained. Experimental results show that various representations of the sustained-release microspheres meet the requirements of preparations, and in-vivo pharmacodynamic studies of rats also show that the sustained-release microspheres can protect articular cartilage and maintain a normal cartilage structure, and have the same curative effect as commercially available dexamethasone acetate injection. Therefore, the dexamethasone sustained-release microsphere which is used for articular cavity injection and has a good release behavior is successfully developed, the advantages of articular cavity injection drugs can be fully played, the drugs can be continuously and stably released, long-acting treatment of arthritis is achieved, and the dexamethasone sustained-release microsphere has important clinical application value and wide market prospects.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a traditional Chinese medicine extracting solution and a related preparation method and application. The traditional Chinese medicine composition is prepared from folium cortex eucommiae, fructus corni, herba cistanche, radix astragali, semen coicis, radix angelicae sinensis, radix codonopsis, rhizoma polygonati, rhizoma dioscoreae and radix glycyrrhizae. Compared with the prior art, the traditional Chinese medicine composition provided by the embodiment of the invention has the advantages that the folium cortex eucommiae has the effects of tonifying liver and kidney and strengthening muscles and bones, the radix astragali has the effects of tonifying qi and relieving arthralgia, the semen coicis has the effects of eliminating dampness and relieving arthralgia, the fructus corni and the herba cistanche have the effects of tonifying kidney yang, the rhizoma polygonati and the Chinese yam have the effects of promoting kidney yin, the angelica sinensis has the effects of replenishing blood, the codonopsis pilosula has the effects of tonifying qi and the liquorice has the effects of harmonizing qi; osteoarthritis related symptoms are improved, and side effects are small.

This invention relates to a method for constructing a humanized pig model of type II collagen and its application, belonging to the field of gene modification technology. The invention first provides a CRISPR-Cas9 system for targeted editing of the porcine type II collagen α1 gene. Using CRISPR / Cas9-mediated homologous recombination, the porcine COL2A1 gene is orally replaced with the human COL2A1 gene. Then, using somatic cell cloning technology, a humanized pig model of type II collagen is constructed, allowing the pig to produce cartilage tissue more similar to that of humans, reducing post-transplant immune rejection. This is expected to fundamentally solve the problem of human cartilage tissue shortage and has significant implications for the treatment of articular cartilage damage, providing a better and more suitable transplant material for the treatment of articular cartilage damage.

The present invention relates to a biomaterial comprising: —a membrane wound patch (a), made of a nanofibrous polymeric scaffold, —a hydrogel (b) including autologous or allogenic bone marrow-derived mesenchymal stem cells, and —a bone wound patch (c) being a nanofibrous scaffold made of polymers, wherein said scaffold has a surface coated with an interrupted coating made of multilayered droplets, said multilayered droplets being droplets composed of at least one layer pair consisting of a layer of polyanions and a layer of polycations, and wherein the bone wound patch (c) further comprises a bone growth factor; wherein the hydrogel (b) is included between the membrane wound patch (a) and the bone wound patch (c).