Integrated three-layer composite scaffold for repairing joint cartilages, and production method thereof

A technology of articular cartilage and layer compounding, applied in prostheses, bone implants, medical science, etc., can solve problems such as weak interlayer bonding, achieve good interlayer bonding, improve overall structural stability, and high flexibility sexual effect

Inactive Publication Date: 2017-12-19
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new technique allows create an integrally shaped tissue engineering device called this scaffolds with special properties such as strength or elasticity. These materials allow cells from blood vessels (artery) to easily penetrate into them when they grow inside it without damaging their own vasculature. They also help guide cell growth within the matrix during regenerative processes. Overall, these technical features make this process more efficient than previous methods like casting calcium salt gel on metal mesh plates used previously.

Problems solved by technology

This patented technical problem addressed in previous studies relates to improving the strength or stability of synthetic implants made from polymerizable resin compositions during medical procedures such as knee joint replacement surgery (MJS). Current methods involve embedding metal reinforcement cables within plastic tubings, but these techniques have limitations due to poor adhesion between layers when compared to integrating prosthesis structures onto single materials like calcium phosphate ceramics called PCA) because they rely on strong chemical interactions at room temperatures.

Method used

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  • Integrated three-layer composite scaffold for repairing joint cartilages, and production method thereof
  • Integrated three-layer composite scaffold for repairing joint cartilages, and production method thereof
  • Integrated three-layer composite scaffold for repairing joint cartilages, and production method thereof

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preparation example Construction

[0038] The present invention also provides a method for preparing an integrated three-layer composite scaffold for articular cartilage repair, comprising the following steps:

[0039] (1) Preparation of sodium alginate slurry: first take a certain amount of sodium alginate and add it to water and stir at a certain temperature. After dissolving, add a certain amount of sodium alginate and stir quickly evenly. Sodium alginate slurry is obtained after sieving, and sealed for preservation;

[0040] Wherein, the concentration of the sodium alginate slurry is 0.08-0.3 g / mL.

[0041] (2) Preparation of bioceramic particles / sodium alginate composite slurry: take a certain amount of bioceramic particles sieved through a 200-800-mesh sieve, add it to the sodium alginate aqueous solution, stir quickly and pass through a 200-800-mesh sieve Sieve through a net to obtain a bioceramic particle / sodium alginate composite slurry, which is sealed and stored;

[0042] Among them, the mass ratio...

Embodiment 1

[0049] (1) Take 0.8g of sodium alginate and add it into 10mL of ultrapure water at 95°C and stir to dissolve it. After dissolving, add 2g of sodium alginate and stir evenly. Pass the uniformly mixed slurry through a 400-mesh sieve to obtain sodium alginate slurry materials, and then sealed and stored.

[0050] (2) Pass the bioactive glass powder through a 400-mesh sieve, then take 1g of bioactive glass powder and 1g of sodium alginate powder and add it to 10mL of sodium alginate aqueous solution (concentration: 0.08g / mL), stir quickly and evenly, and mix The uniform slurry is passed through a 400-mesh sieve to obtain a bioactive glass particle / sodium alginate composite slurry, which is then sealed and stored.

[0051] (3) Using CAD / CAM computer-aided software to design the appearance and internal structure of the three-layer composite bracket, the obtained bracket model is a cylinder (diameter 8mm, height h is 3mm), the internal pore diameter is 200μm, the first eight slurry...

Embodiment 2

[0055] (1) Take 0.8g of sodium alginate and add it into 10mL of ultrapure water at 95°C and stir to dissolve it. After dissolving, add 2g of sodium alginate and stir evenly. Pass the uniformly mixed slurry through a 300-mesh sieve to obtain sodium alginate slurry materials, and then sealed and stored.

[0056] (2) Pass the bioactive glass powder through a 300-mesh sieve, then take 0.5g of bioactive glass powder and 1.5g of sodium alginate powder and add it to 10mL of sodium alginate aqueous solution (concentration: 0.08g / mL), stir quickly and evenly, Pass the uniformly mixed slurry through a 300-mesh sieve to obtain a bioactive glass particle / sodium alginate composite slurry, which is then sealed and stored.

[0057] (3) Using CAD / CAM computer-aided software to design the appearance and internal structure of the three-layer composite bracket, the obtained bracket model is a cylinder (diameter 8mm, height h is 3mm), the internal pore diameter is 400μm, the first eight pulp su...

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Abstract

The invention provides an integrated three-layer composite scaffold for repairing joint cartilages, and a production method thereof. The composite scaffold comprises a cartilage layer, a calcified subchondral bone plate layer and a spongy bone layer which are sequentially superposed from bottom to top, the composite scaffold is formed in a one-shot manner through three-dimensional printing, the cartilage layer is a sodium alginate hydrogel porous layer, the calcified subchondral bone plate layer is a biological ceramic particle and sodium alginate composite hydrogel compact layer, the spongy bone layer is a biological ceramic particle and sodium alginate composite hydrogel porous layer, and the sodium alginate components in all above layers undergo ionic cross-linking to form an integrated structure, so every layer of the composite scaffold has a specific composition and a specific structure, the composite scaffold has good interlayer binding force, and the integral structure stability of the composite scaffold is improved. The invention also provides the production method of the integrated three-layer composite scaffold for repairing joint cartilages. The method has the advantages of simplicity, easiness in enforcement, easiness in control of technologic parameters, acceleration of the promotion and application of a three-dimensional printing technology in the biologic field, and wide market prospect.

Description

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Claims

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Application Information

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Owner UNIV OF SHANGHAI FOR SCI & TECH
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