502 results about "Composite hydrogels" patented technology

The invention provides a preparation method of a cell culture three-dimensional scaffold and cell culture meat, which comprises the following steps: firstly, preparing a gelatin-carrageenan mixed solution and a gel precursor solution of transglutaminase, dividing into two parts, incubating at constant temperature to obtain two parts of composite hydrogel, randomly freeze-drying one part to obtain aerogel, and freeze-drying the aerogel to obtain the cell culture three-dimensional scaffold. Stacking on the other part and incubating at constant temperature again to obtain the prefabricated double-layer gel. The prefabricated double-layer gel is directionally frozen, ice crystals grow upwards from the bottom, freezing is stopped after the temperature is reduced to the set temperature, and the cell culture three-dimensional scaffold is obtained through drying. The stent adopts an ordered-disordered partition design, parallel micro-channels are formed in the lower layer by using a directional ice template method, and muscle fiber arrangement is simulated; a porous spongy structure is constructed on the upper layer by using a random ice template method, and is adapted to adipocyte proliferation. Two layers of interfaces are interpenetrated and communicated, natural mechanical gradients are combined, natural tissue characteristics are re-engraved, the traditional limitation is broken through, the cell co-culture efficiency and the cultured meat quality are improved, and industrialization is promoted.

The invention provides a photo-thermal evaporation material based on black titanium dioxide as well as a preparation method and application of the photo-thermal evaporation material. The preparation method comprises the following steps: mixing urea, absolute ethyl alcohol and tetrabutyl titanate into a solution A, mixing absolute ethyl alcohol, ultrapure water and hydrochloric acid into a solution B, dropwise adding the solution B into the solution A, mixing to form a white colloid, heating in a water bath, drying, and calcining in a nitrogen atmosphere to obtain black titanium dioxide powder; the preparation method comprises the following steps: fully mixing a certain amount of black titanium dioxide, sodium alginate and ultrapure water to form a uniform dispersion liquid, dipping the pretreated polyurethane sponge in the dispersion liquid, and crosslinking with a calcium chloride solution to prepare the photo-thermal evaporation material of the black titanium dioxide-calcium alginate composite hydrogel. The photo-thermal evaporation material breaks through the photo-thermal application bottleneck of traditional titanium dioxide, has excellent evaporation rate and seawater desalination performance, and can effectively remove various printing and dyeing wastewater to obtain clean water.

The invention discloses a method for constructing a multicellular living body material by adopting a droplet bioreactor, which belongs to the crossing field of biological materials and microbial engineering, and comprises the following steps: (1) resuspending different cells in different polymer solutions to prepare degradable or phase-separable hydrogel particles containing cells; (2) dispersing the hydrogel particles in a cross-linkable hydrogel matrix to form a composite hydrogel; and (3) curing the composite hydrogel, and then carrying out degradation treatment to obtain the liquid cavity structure multicellular system bioreactor with spatial partition and dynamic interaction characteristics. According to the invention, ordered distribution and metabolism synergy of different microorganisms in space can be realized, controllable degradability and excellent mass transfer performance are realized, bacterial slow release and metabolite exchange can be maintained, and the method is suitable for long-term stable operation of a continuous flow reactor. The method has wide application prospects in the fields of green biological manufacturing, renewable energy source production, environmental restoration, biomedical engineering and the like.

The invention provides glycyrrhizic acid / glycyrrhetinic acid-triethanolamine composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of preparation of biological medicine carriers and composite materials. According to the invention, glycyrrhizic acid or glycyrrhetinic acid is taken as a raw material, triethanolamine is taken as a cross-linking regulating agent, and the composite hydrogel with stable mechanical properties, high drug loading efficiency and anti-inflammatory synergistic activity is prepared through a mild physical and chemical cross-linking reaction; the preparation process of the composite hydrogel does not need a toxic cross-linking agent, the reaction condition is mild, the raw materials are cheap and easy to obtain, and large-scale production can be realized; the composite hydrogel presents a multi-group ionic bond cross-linked structure, can be used as a carrier of a pH responsive drug, and has good practicability.

The invention provides a composite hydrogel for infectious bone defect repair and a preparation method thereof, and belongs to the technical field of bone defect repair, the composite hydrogel comprises a three-dimensional porous network structure hydrogel and a bioactive unit, and the bioactive unit is loaded in the three-dimensional porous network structure hydrogel; the hydrogel with the three-dimensional porous network structure is prepared from photo-crosslinked methacrylated silk fibroin and nano-hydroxyapatite; the bioactive unit comprises a strontium metal organic framework loaded with curcumin. According to the invention, the photo-crosslinked methacrylated silk fibroin provides excellent biocompatibility; as an ion / drug dual carrier, the strontium metal organic framework can continuously release strontium ions and bidirectionally regulate bone metabolism (promoting osteogenesis and inhibiting osteoclast), and the porous structure of the strontium metal organic framework can efficiently load a hydrophobic drug curcumin (Cur). Curcumin has strong antibacterial and anti-inflammatory functions; the nano-hydroxyapatite can obviously enhance the mechanical strength of the hydrogel.

The invention discloses starch-collagen composite hydrogel as well as a preparation method and application thereof. Collagen is catalyzed by microbial transglutaminase to form a covalent cross-linked network, and meanwhile, hydroxypropyl starch is introduced to construct a physical interpenetrating network through molecular chain penetration and hydrogen-bond interaction; and chondroitin sulfate is further integrated to strengthen the network structure and biological activity through electrostatic interaction. The method is mild in condition and does not need a toxic chemical cross-linking agent, the obtained composite hydrogel has an interpenetrating double-network structure and has excellent mechanical properties, enzymatic degradation resistance and cell affinity, the compression modulus of the composite hydrogel is remarkably improved, the composite hydrogel can keep structural stability for a long time in a collagenase environment, cell adhesion and proliferation can be effectively promoted, and the composite hydrogel has a good application prospect. The hydrogel can be widely applied to tissue engineering scaffolds, wound dressings, drug sustained-release carriers and cartilage repair materials.

The invention discloses composite hydrogel bio-ink with a function of space-time delivery of double growth factors as well as a preparation method and application of the composite hydrogel bio-ink, and belongs to the technical field of biomedical materials and tissue engineering. According to the preparation method, imidazolyl-modified methacrylated gelatin and double-bonded PF127 are compounded, and meanwhile, free vascular endothelial growth factors and connective tissue growth factor-loaded PLGA microspheres are entrapped in a system, so that the bio-ink with excellent printability, high adhesion, swelling resistance and space-time delivery function is formed; the bio-ink physically has the advantages of high printing fidelity, low swelling property, high mechanical strength and strong tissue adhesion of a synthetic material; in biology, the system can be used as an intelligent carrier to realize programmed space-time delivery of various growth factors, so that complex cell biological behaviors are accurately arranged, and real regeneration of functional tissues is guided.

The invention discloses injectable double-drug delivery hydrogel and a preparation method thereof, and belongs to the technical field of biomedical materials. According to the method, two nano microspheres with different charges are respectively prepared by utilizing the characteristics of A-type gelatin and B-type gelatin, a negatively charged medicine EGCG is specifically carried by the positively charged A-type gelatin, and a positively charged medicine SAG is carried by the negatively charged B-type gelatin microsphere; and finally, mixing the two gelatin drug-loaded microspheres into a material taking gelatin and zirconium ions as a substrate to form the composite hydrogel. The hydrogel realizes immune regulation and osteogenesis regulation, also realizes long-acting release of the two drugs, effectively solves the problems of bone resorption, difficulty in healing and the like of host tissues through synergistic regulation of inflammation and mobilization of osteogenesis genes, realizes personalized treatment, and improves the clinical treatment effect and efficiency.

The invention discloses a composite hydrogel adsorbent and a preparation method and application thereof, and belongs to the technical field of wastewater treatment.The preparation method comprises the specific steps that S1, neutralized acrylic acid, acrylamide and a cross-linking agent are added into deionized water and stirred to be uniform, and a precursor solution is obtained; s2, adding alkali-activated fly ash into the precursor solution, uniformly mixing, sequentially adding alkali liquor and an initiator, and fully stirring for reaction to obtain a mixed solution; and S3, curing the obtained mixed solution in a mold, washing with water, and drying to obtain the composite hydrogel adsorbent. According to the invention, the reaction system is optimized, so that the super-fast polymerization curing of the hydrogel is realized; the prepared composite hydrogel has excellent mechanical property and metal ion adsorption property; the whole preparation process is simple to operate, high in gel forming speed, free of light / heat initiation, mild in condition and low in cost, and can be applied to adsorption of heavy metal ions in wastewater.

The invention provides an aluminum oxide aerogel composite material as well as a preparation method and application thereof, and belongs to the technical field of aluminum oxide aerogel preparation. The preparation method provided by the invention comprises the following steps: (1) preparing aluminum sol by taking coal gangue as an aluminum source; (2) mixing the aluminum sol obtained in the step (1) with aluminum silicate fibers, and performing gelation to obtain composite hydrogel; and (3) mixing the composite hydrogel obtained in the step (2) with ethanol, aging, mixing with a modifier, modifying, and carrying out graded normal-pressure drying to obtain the aluminum oxide aerogel composite material, the modifier in the step (3) is one or more of absolute ethyl alcohol, tetraethoxysilane and normal hexane. The alumina aerogel composite material prepared by the preparation method provided by the invention has the characteristics of low density, low heat conductivity coefficient and high strength, and is suitable for the high-temperature processing field of special materials and the aerospace field.

The invention discloses light-driven toxin-enriched composite hydrogel as well as a preparation method and application thereof. The composite hydrogel comprises light-driven hydrogel and detection hydrogel, the light-driven hydrogel is agarose hydrogel doped with Au (at) Ag core-shell nano particles; the detection hydrogel is a double strand formed by an okadaic acid aptamer and a complementary sequence cDNA thereof, and a double strand formed by a domoic acid aptamer and a complementary sequence DNAzyme thereof, the hairpin H1 is used for modifying a quenching group BHQ2 at the 3'end, the hairpin H2 is used for modifying a fluorophore Cy3 at the neck part, the hairpin H3 is used for modifying a fluorophore FAM and a quenching group BHQ1 at the two ends respectively, and the metal ion doped agarose hydrogel is used for catalyzing DNAzyme cyclic shearing; and the photo-thermal driving unit is positioned on the detection function unit. According to the present invention, with the composite system of upper layer photo-thermal enrichment and lower layer dual-signal detection, the rapid and high-sensitivity simultaneous detection of the okadaic acid and the domoic acid is achieved through the combination of the photo-thermal transpiration effect and the HCR and DNAzyme cyclic shearing reaction;

The invention is applicable to the technical field of polymer biomedical hydrogel materials, and provides a preparation method and application of multifunctional agarose-based particle composite hydrogel based on liquid-liquid phase separation, and the agarose-based particle composite hydrogel is a product formed by introducing microsphere particles into an agarose hydrogel body matrix; the microsphere particles are formed by a prepolymer and sodium lignin sulfonate through phase separation mediated by a composite behavior based on non-covalent interaction; the prepolymer is obtained by carrying out amine-epoxy reaction on an amino compound and an epoxy compound in water. According to the prepared agarose-based particle composite hydrogel, a microsphere particle structure is formed on the surface of an agarose matrix while positively charged amino groups and sodium lignin sulfonate are introduced, so that the multifunctional agarose-based particle composite hydrogel is prepared.

The application discloses a kind of super tough polyvinyl alcohol composite hydrogel with biological activity and preparation method thereof.The polyvinyl alcohol composite hydrogel refers to that polyvinyl alcohol (PVA) is added into NaOH solution, heated to 90 DEG C, and stirred vigorously for 2 hours, after PVA is completely dissolved, a certain proportion of sodium lignosulfonate (LS) and rutin (RT) powder is added, after sodium lignosulfonate and rutin are completely dissolved, it is air-dried into 0.3~0.5 mm thick film at room temperature, then it is immersed in 20~30 mL 10 wt% NaCl solution and swells for 3~5 hours, to obtain PVA-LS-RT composite hydrogel.The polyvinyl alcohol composite hydrogel prepared by the application has super strong mechanical property, and has higher antibacterial, antioxidant and wound healing capacity, and has good application prospect in wound dressing, artificial cartilage and flexible electronics and other cutting-edge fields.

The present invention relates to a 3D printing composite hydrogel microneedle, the 3D printing composite hydrogel microneedle comprises methacrylated chitosan, o-nitrobenzyl alcohol polyethylene glycol, resveratrol and a liposome, and the resveratrol is entrapped in the liposome. The preparation method comprises the following steps: preparing resveratrol-loaded lipidosome, and preparing the 3D printing composite hydrogel microneedle. Through organic combination of the pharmacological activity of resveratrol, the controllable skeleton of PEGNB, the adhesion and antibacterial characteristics of CSMA, the precise drug delivery capability of a microneedle and the precise preparation advantage of 3D printing, the innovative microneedle patch with long-acting drug delivery, excellent biocompatibility and myocardial repair function is provided; and a new solution is provided for myocardial injury treatment.

The invention provides an edible fresh flower pesticide residue detection device and a detection method and device thereof, and relates to the technical field of agricultural product detection, the edible fresh flower pesticide residue detection device comprises a housing, a sampling assembly, a detection assembly and a control unit; the sampling assembly adopts a disposable hydrogel sampling piece, is composed of a composite hydrogel matrix containing Raman active nanoparticles, and is used for non-destructively transferring and enriching pesticide residues on the surfaces of petals; the detection assembly adopts a non-dispersive optical system comprising an excitation light source, a narrow-band filter array corresponding to a target pesticide characteristic Raman peak and a single-point photoelectric detector array to perform targeted detection on a Raman signal with a specific wavelength; according to the method, nondestructive efficient sampling of fragile petals is achieved through the specially-made hydrogel sampling piece, the equipment cost is greatly reduced through a non-dispersive optical framework, the problem that an existing detection method cannot give consideration to on-site pre-screening of rapid, low-cost, portable and nondestructive detection is solved, and the method is suitable for rapid detection of commercial tenants, markets and supervision departments.

The invention relates to a lignin-derived carbon aerogel loaded metal nano enzyme and a synthesis method and application thereof, the synthesis method comprises the following steps: adding sodium lignin sulfonate, CoCl2. 6H2O and NiCl2. 6H2O into deionized water, and carrying out ultrasonic dispersion to obtain a lignin-metal solution; uniformly mixing and stirring the lignin-metal-PVA composite precursor solution with a polyvinyl alcohol aqueous solution to obtain a lignin-metal-PVA composite precursor solution; carrying out at least three times of freezing-unfreezing circulation treatment on the lignin-metal-PVA composite hydrogel to obtain lignin-metal-PVA composite hydrogel; carrying out freeze drying treatment to remove moisture, so as to obtain a lignin-metal-PVA composite aerogel precursor; and carrying out pyrolysis treatment in a nitrogen environment, and naturally cooling to room temperature. The lignin-derived carbon aerogel loaded Co-Ni bimetallic nano-enzyme prepared by the invention shows excellent catalytic activity, product selectivity and cycle stability in photocatalytic CO2 reduction reaction of high and low concentration CO2 due to bimetallic synergistic catalytic effect, high specific surface area and stable three-dimensional skeleton.

The invention discloses an elastomer enhancement strategy based on a covalent organic framework nano confinement effect, and belongs to the field of elastomer enhancement. Aiming at the defects of the existing polymer material in mechanical properties or functional characteristics, the COF is introduced into a polymerization system through a dispersion process adaptive to different polymerization reaction characteristics: in emulsion polymerization, the COF is pre-dispersed in an acrylate monomer, and then the solid elastomer is prepared through emulsification, polymerization initiation, demulsification and drying. In condensation polymerization, the COF dispersion liquid is added into the polyurethane prepolymer, and the enhanced elastomer is prepared through chain extension and curing. In free radical polymerization, a COF aqueous dispersion is blended with monomers such as acrylamide, and the composite hydrogel is prepared through thermal initiation polymerization. According to the method, the mechanical strength, the toughness and the functional characteristics of the obtained composite material are remarkably improved by utilizing the regular pore channels and the active surface of the COF.

The invention relates to an artificial periosteum suitable for a complex bone surface. The artificial periosteum is an integrated single-layer membrane. The artificial periosteum is provided with an anti-adhesion area, a directional pore channel structure area and a bone contact area which are sequentially distributed in the thickness direction. The directional pore channels are sequentially filled with composite hydrogel for filling bone surface pores and promoting bone repair and bonding gel for bonding bone surfaces in the extending direction of the directional pore channels; an expanding agent and prestretching memory polymer fibers are dispersed in a matrix of the artificial periosteum; the expanding agent is enriched in the matrix of the directional pore channel structure area and the bone contact area and is used for driving the composite hydrogel to leave the directional pore channel so as to seal bone surface gaps or cracks; and the pre-stretched memory polymer fibers are enriched in the matrix of the anti-adhesion area and are used for limiting the expansion direction of the expanding agent. The artificial periosteum can solve the technical problems that in the prior art, the attaching effect of the artificial periosteum on the complex bone surface is poor, and the long-term reliability is poor.

The invention relates to the technical field of gas adsorption materials, in particular to a heteropoly acid modified GO-coated MMT composite material and a preparation method and application thereof. The preparation method comprises the following steps: ultrasonically dispersing graphite oxide in deionized water, stirring for 2-4 hours to obtain a graphite oxide solution, adding methylcyclopentadienyl manganese tricarbonyl into ethylene glycol, and stirring for 12-24 hours to obtain an MMT solution; pouring the graphite oxide solution into the MMT solution, reacting at 150-180 DEG C for 8-12 hours, washing, and freeze-drying to obtain GO-coated MMT composite hydrogel; and adding the GO-coated MMT composite hydrogel into deionized water, then adding heteropoly acid, stirring at 60-80 DEG C for 8-12 hours, and carrying out suction filtration and washing to obtain the heteropoly acid modified GO-coated MMT composite material. According to the heteropolyacid modified GO (at) MMT composite material disclosed by the invention, a complex with strong electrostatic adsorption force can be formed on the surface of GO (at) MMT by introducing heteropolyacid, and meanwhile, Bronsted acid sites and Lewis acid sites are increased, so that the adsorption performance is enhanced, and low-concentration ammonia gas adsorption is realized.

The invention is applicable to the technical field of new energy materials and water treatment, and provides solar-driven multifunctional composite hydrogel and a preparation method and application thereof, the multifunctional composite hydrogel comprises dual-network hydrogel, a nanofiber skeleton and functional particles; the double-network hydrogel is formed by interpenetrating and cross-linking a polyelectrolyte hydrogel and a temperature-sensitive hydrogel; the functional particles are loaded in a three-dimensional porous network structure formed by the double-network hydrogel and the nanofiber skeleton. When the device floats on the surface of a water body, efficient solar interface evaporation water production, stable power generation based on the water photovoltaic effect and efficient adsorption removal of nitrogen and phosphorus nutritive salt in the water body can be synchronously achieved under illumination, and therefore algae growth is inhibited. According to the invention, the integrated collaborative management of water collection, energy conversion and ecological restoration is realized, the preparation process is simple, the environmental adaptability is high, and an innovative scheme is provided for solving the distributed water-energy supply and ecological environment problems in coastal, island and other regions.

The invention provides a composite hydrogel for promoting diabetic bone regeneration, the composite hydrogel is composed of L-histidine modified chitosan, oxidized konjac glucomannan, Zn and nano clay, and in-situ gelation is realized through coordination regulation, interlayer exchange and dynamic covalent bond synergistic effect. Through combined application of coordination regulation, interlayer exchange and dynamic covalent bonds, on-demand staged delivery of various ions is realized. According to the innovative design, the adhesive property and mechanical integrity of the hydrogel at a defect part are maintained, intelligent response can be realized according to the change of a bone microenvironment, and the defect that a single release mechanism in the prior art is difficult to meet the complicated demand of diabetic bone regeneration is overcome.

The invention discloses MoSe2 nano-enzyme-selenium-rich probiotic composite hydrogel and a preparation method and application thereof, the composite hydrogel comprises a hydrogel matrix and functional components dispersed in the hydrogel matrix, and the functional components comprise anti-MoSe2 nano-enzyme and selenium-rich probiotics wrapped by an antioxidant film. According to the MoSe2 nano-enzyme-selenium-enriched probiotic composite hydrogel provided by the invention, the sonodynamic characteristics of the MoSe2 nano-enzyme and the biological activity of the selenium-enriched probiotics are perfectly fused: under ultrasonic stimulation, the MoSe2 nano-enzyme not only can directly and efficiently generate reactive oxygen species (ROS), but also can catalyze low-concentration hydrogen peroxide to generate a large amount of hydroxyl radicals (. OH); broad-spectrum killing of various pathogenic bacteria is achieved, and the risk of drug resistance evolution of bacteria is reduced from the source; meanwhile, antibiotics secreted by the selenium-enriched probiotics can form a synergistic sterilization effect, so that the pathogenic bacterium removal effect is further enhanced.

The invention belongs to the technical field of biomedical materials, and discloses a viola philippica exosome-loaded composite hydrogel as well as a preparation method and application thereof, the composite hydrogel is prepared by mixing methacrylated polylysine (PLMA), oxidized dextran (ODex), viola philippica exosome (V-E), a photoinitiator and a physiologically compatible solvent and performing illumination crosslinking; the preparation method comprises the following steps: respectively preparing PLMA and ODex solutions, extracting and purifying V-E, adding a photo-crosslinking agent (LAP), mixing the components to obtain a precursor liquid, and carrying out in-situ curing molding through ultraviolet-visible light irradiation. The composite hydrogel provided by the invention solves the problems that the existing wound dressing is difficult to fit with irregular wounds, is antibacterial and easy to resist drugs, and lacks active anti-inflammatory and efficient healing promotion capabilities, and is suitable for repair treatment of infectious open wounds such as burns, trauma, diabetic foot ulcer and postoperative infected incisions.

This invention discloses a composite hydrogel based on a polysaccharide-based hybrid dual network, its preparation method, and its applications, belonging to the field of marine polysaccharide technology. Based on the important role of amorphous calcium phosphate, a precursor in biomineral formation, in mineralization, this invention prepares a multifunctional composite hydrogel with wet bonding, antibacterial, and remineralization functions. This composite hydrogel can achieve rapid and convenient repair of enamel demineralization. This invention prepares oxidized sodium alginate via an alcohol-aqueous phase using the sodium periodate method. Sodium alginate reacts with carboxymethyl chitosan and dopamine through a Schiff base reaction to form dynamic imine bonds, thus preparing an in-situ self-crosslinking hydrogel. Simultaneously, amorphous calcium phosphate is introduced for secondary crosslinking, preparing a dense dual-network composite hydrogel. The composite hydrogel prepared by this invention has an interconnected three-dimensional porous structure, stable mechanical properties, and uniformly dispersed amorphous calcium phosphate in the form of nanospheres. The composite hydrogel prepared by this invention provides an integrated strategy with clinical translational potential for orthodontic enamel demineralization, with broad market prospects.

The application provides a kind of load exosome composite hydrogel and preparation method thereof, belong to biomaterial and drug delivery technical field;Its preparation method includes: modified chitosan;Modified hyaluronic acid;Preparation of biphasic calcium phosphate nanoparticles;Preparation of composite hydrogel.The application is through nucleophilic ring-opening reaction of 1,2-epoxy butane and the hydroxyl group of chitosan, form hydroxybutyl ether bond, give hydroxybutyl chitosan temperature sensitive characteristics, then, again, after activation 3,4-dihydroxyphenylalanine is condensed with hydroxybutyl chitosan, form amide bond, to graft 3,4-dihydroxyphenylalanine on hydroxybutyl chitosan, after modification of chitosan, 3,4-dihydroxyphenylalanine can form strong adhesion interface with cartilage, synovial membrane and other tissues through hydrogen bond, pi-pi stacking and metal coordination, thereby effectively prolonging the residence time of hydrogel in joint.

The invention provides temperature-sensitive enhanced composite hydrogel as well as a preparation method and application thereof. The temperature-sensitive enhanced composite hydrogel is prepared from the following raw materials: a triblock copolymer, hydroxybutyl chitosan and an aqueous medium. According to the invention, the synthetic polymer material and the natural biopolymer derivative are compounded, so that the defects of a single-component material are overcome, the mechanical strength and stability of the hydrogel are remarkably improved, and the prepared hydrogel has good biocompatibility and degradability.

The invention discloses an adhesive compound with an adhesive property optimized based on metal hydroxides as well as a preparation method and application of the adhesive compound, and belongs to the technical field of biological adhesives. The present invention relates to an adhesive composition comprising an adhesive precursor consisting of a protein-polyphenol composite hydrogel and a hydrogen bond destructive small molecule compound capable of network reconstitution comprising beta-folding formation in aqueous phase grafting comprising a metal hydroxide having the characteristics of: (a) a hydration enthalpy value of from-1000 kJ / mol to-4000 kJ / mol; (b) a dissociation constant of from 6 pKa to 13.5 pKa; (c) a water exchange rate of 105 S <-1 > to 10 < 10 > S <-1 >. The adhesion compound can be networked to form an advanced structure when encountering water, not only can generate underwater lap joint shear strength of more than 1MPa, but also can tolerate underwater long-term soaking and temperature change from-196 DEG C to 100 DEG C, and meanwhile, the adhesion compound also has good biocompatibility, can meet the requirement of the environment in a human body on tissue adhesion safety, and has good application prospects. Stability suitable for in vivo tissue repair and industrial applications is exhibited.

The invention relates to the technical field of biomedical materials, and provides a preparation method of a fibroin nanofiber reinforced silk protein gel material, the gel material and application, fibroin nanofibrils are prepared through a mechanical grinding method and introduced into composite hydrogel, the Young modulus reaches 4.68 MPa, and the fibroin nanofiber reinforced silk protein gel material is suitable for osteochondral repair and drug delivery.

The invention provides a core-shell structure microgel system. The core-shell structure microgel system comprises a core and a shell coating the core, the core is composed of a composite hydrogel of methacrylated gelatin and methacrylated chitosan; the shell is formed by double crosslinking of polyethylene glycol diacrylate and alginate. The core serves as a functional core, provides a highly simulated natural extracellular matrix and maintains pancreas islet activity, and the shell serves as a barrier to protect the core, regulate material exchange and provide mechanical support. The core-shell structure microgel system allows diffusion of glucose, oxygen and insulin and blocks immune globulin, cell factors and immune cells, so that fibrosis wrapping is reduced to the greatest extent.

The application relates to a machine learning assisted optimization multifunctional composite hydrogel wound dressing and a preparation and optimization method thereof, and belongs to the hydrogel field. The hydrogel is constructed by ion crosslinking of sodium alginate and calcium ions and chitosan quaternary ammonium salt, and a chemical crosslinking network formed by polyacrylamide is interpenetrated with the network. The hydrogel has high water absorption, strong antibacterial property, reliable adhesion, sensitive strain sensing property and excellent mechanical property, and provides ideal healing for wounds. The method innovatively integrates machine learning intelligent optimization: by establishing a formula-process-performance database, training a Gaussian process regression prediction model, and adopting a Bayesian optimization algorithm for global optimization, optimal preparation parameters for specific performance requirements are efficiently and accurately determined. The method breaks through the traditional trial-and-error development mode depending on experience, realizes high performance, customization and rapid development of the hydrogel dressing, and provides a new paradigm for design and preparation of a new generation of wound care products.