1372 results about "Composite hydrogels" patented technology

The invention discloses injectable sodium hyaluronate-silk fibroin composite hydrogel and a preparation method and application thereof.The injectable sodium hyaluronate-silk fibroin composite hydrogel is composed of sodium hyaluronate composite gel particles and a sodium hyaluronate solution, and the sodium hyaluronate composite gel particles comprise silk fibroin sponge microspheres and sodium hyaluronate gel particles; the silk fibroin sponge microspheres are loaded on the sodium hyaluronate gel particles, the silk fibroin sponge microspheres are physical crosslinking microspheres, the particle size D50 is 10-30 [mu] m, and the particle size D90 is within 100 [mu] m; the sodium hyaluronate gel particles are chemical cross-linked particles, the particle size D50 is 150-300 microns, and the particle size D90 is within 800 microns. After the sodium hyaluronate gel particles are in contact with tissues, sodium hyaluronate is preferentially degraded, and silk fibroin exposed in the degradation process has better degradation resistance and an effect of stimulating generation of collagen fibers, so that in-situ fixation of the composite gel particles is realized, and an instant and lasting filling effect is achieved; the material is a safe and effective medical beauty filling material.

The invention belongs to the technical field of hydrophilic gel and water extraction from air, and particularly relates to surface-hydrophobic core-shell structure composite moisture absorption hydrogel and a preparation method and application thereof.The preparation method specifically comprises the steps that hydrophilic gel loaded with moisture absorption salt is placed in a hydrophobic polymer solution, and a phase inversion method is used for preparing the core-shell structure composite moisture absorption hydrogel; a porous hydrophobic polymer shell layer is loaded on the surface of the hydrophilic gel, so that the composite moisture absorption hydrogel with the moisture absorption salt loaded hydrophilic gel as a core layer and the porous hydrophobic polymer as the shell layer is obtained, and the prepared composite moisture absorption hydrogel can prevent leakage of the moisture absorption salt and is high in water absorption performance, good in long-term use stability and simple in preparation method. The prepared composite moisture absorption hydrogel can be widely applied to the fields of air water taking, humidity control and agricultural moisturizing.

The invention belongs to the technical field of metal organic frameworks, and particularly relates to a high-performance photocatalytic metal organic framework antibacterial material as well as a preparation method and application thereof. The preparation method comprises the following steps of: growing a metal organic framework UiO 66 which takes a cerium element as a metal node on a single-layer graphene oxide UiO66 (at) GO in situ, loading arginine small molecules in the MOF framework to obtain a high-performance photocatalytic MOF antibacterial material UiO66 (at) GO (at) arg, forming a nano hydrogel with a stable three-dimensional structure with chitosan, and performing antibacterial treatment by using the nano hydrogel as a wound dressing. The Ce-based MOF composite QCS / GO-UiO 66-coated arg / PNIPAm hydrogel prepared by the preparation method disclosed by the invention has excellent properties such as elasticity, adhesive power, water absorption and biocompatibility; and under illumination, the photocatalyst has an excellent photocatalytic sterilization effect, and has a good killing effect on escherichia coli and staphylococcus aureus.

The invention discloses application of sodium alginate-carboxymethyl chitosan composite hydrogel in preparation of a biological bacterial fertilizer, the sodium alginate-carboxymethyl chitosan composite hydrogel is used for preparation of the biological bacterial fertilizer, and is further used for preparation of the biological bacterial fertilizer with plant growth-promoting rhizobacteria as an effective component, and the sodium alginate-carboxymethyl chitosan composite hydrogel can be stored for a long time and has a good application prospect. The growth promoting effect is stably exerted. The plant growth-promoting bacteria are effectively wrapped and efficiently delivered through a nanometer means to enhance the growth-promoting effect on crops, the adaptability of the plant growth-promoting bacteria to the acid environment is effectively improved, and the advantage of the plant growth-promoting bacteria for promoting plant growth in acid soil is expanded. The biological bacterial fertilizer is suitable for neutral and acidic environments, and the effects of the biological bacterial fertilizer in the aspects of soil remediation and improvement, crop quality and efficiency improvement, crop stress resistance improvement and the like are fully exerted, so that the purposes of losing weight and improving efficiency are achieved.

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The invention discloses a biomass charcoal composite hydrogel slow-release fertilizer as well as a preparation method and application thereof, and belongs to the field of composite hydrogel and fertilizer preparation. The invention provides a biomass charcoal composite hydrogel slow release fertilizer, which comprises biomass charcoal, hydrogel fixed on the pores and surface of the biomass charcoal, and an element fertilizer mixed in the hydrogel, and the hydrogel is prepared from metal cations and alginate. The invention provides a strategy of'in-hole in-situ gelation ', hydrogel is prepared in situ in gaps of the biochar, and the biomass charcoal composite hydrogel slow-release fertilizer is prepared. The biochar and the hydrogel in the slow-release fertilizer are high in bonding strength and mechanical strength, so that the slow-release fertilizer has the slow-release function of the fertilizer and also has the capability of improving soil.

The invention discloses a cellulose-based in-situ growth MOF composite aerogel preparation method, which comprises: mixing cellulose powder and dimethylimidazole, adding into deionized water, gradually adding cobalt nitrate and zinc chloride, uniformly stirring, carrying out a heating reaction, adding polyethyleneimine, uniformly stirring, adding a cross-linking agent, carrying out cross-linking, washing, and drying to obtain the cellulose-based in-situ growth MOF composite aerogel. The composite hydrogel is obtained; and finally, sealing, heating and baking the composite hydrogel, washing and drying to obtain the composite aerogel. According to the method, the MOF is synthesized on the cellulose in situ under the low-temperature water phase condition, the composite aerogel containing the MOF material is obtained, the MOF material synthesized on the cellulose in situ has good porosity and particle size and uniformly covers the cellulose, loss of active components is avoided, the problem that the MOF material is prone to agglomeration is solved, and the preparation method is suitable for industrial production. Meanwhile, the adsorption performance is also effectively improved, the adsorbent has good affinity with water, and the surface can be promoted to adsorb three metal ions of vanadium, molybdenum and nickel at the same time.

The invention provides a self-repairing and self-adhering nano composite hydrogel material as well as a preparation method and application thereof. The self-repairing and self-adhering nano composite hydrogel material provided by the invention comprises a boric acid derivative modified first monomer, a second monomer and a conductive filler. A macromolecular network formed by the two monomers generates crosslinking through reversible interaction so as to improve the mechanical strength of the hydrogel, and meanwhile, the hydrogel is endowed with reliable self-repairing performance; in addition, a macromolecular chain of the hydrogel contains more free active groups, and the hydrogel can be adhered to materials such as skin through reversible interaction among the groups. The doping of the conductive filler is also beneficial to improving the mechanical property, the conductivity and the sensing property of the hydrogel, so that a flexible wearable sensor assembled by the hydrogel can sensitively and stably monitor a human body motion signal and an electrophysiological signal.

The invention discloses composite hydrogel as well as a preparation method and application thereof. The curcumin-EGCG composite hydrogel is prepared by forming a complex through hydrogen-bond interaction between gelatin and epigallocatechin gallate and carrying out chemical crosslinking through Schiff base reaction of curcumin and gelatin. The composite hydrogel disclosed by the invention has a self-healing characteristic or viscosity and a shear thinning characteristic, and is beneficial to local application. The composite hydrogel is loose and porous in structure, the drug loading rate can be increased, the drug can be slowly and controllably released, the treatment effect of the composite hydrogel in androgenetic alopecia is promoted, meanwhile, the solubility of a drug monomer can be remarkably improved, and the problem that the drug solubility is low is solved. The composite hydrogel provided by the invention provides an effective transdermal drug delivery preparation for treatment of skin diseases, and has good clinical application prospects and development values.

The invention relates to the technical field of high polymer materials, in particular to a high-entropy alloy modified polyvinyl alcohol / polypyrrole composite hydrogel material as well as a preparation method and application thereof. Firstly, a polypyrrole aqueous solution is prepared through chemical oxidative polymerization, and high-entropy alloy nanoparticles are synthesized through a Joule thermal technology; and then mixing a polypyrrole aqueous solution, the high-entropy alloy nanoparticles and a polyvinyl alcohol aqueous solution, and adding a cross-linking agent and a catalyst to prepare the high-entropy alloy modified polyvinyl alcohol / polypyrrole composite hydrogel material. According to the composite hydrogel, under the synergistic effect of the high-entropy alloy, the light absorption performance is remarkably improved, wide-spectrum efficient absorption of ultraviolet rays, visible light and near-infrared light in a solar spectrum is achieved, and meanwhile the mechanical strength and chemical stability of the material are enhanced. The preparation process is simple, the cost is low, and the prepared composite hydrogel has wide application prospects in the fields of seawater desalination, wastewater treatment and the like as a solar interface evaporator.

The invention relates to a liquid metal / MXene / sodium alginate / polyacrylamide composite hydrogel material as well as a preparation method and application thereof. The hydrogel material comprises liquid metal microspheres, a hierarchical porous network formed by sodium alginate and polyacrylamide, and flaky MXene. The preparation method comprises the following steps: S1, adding liquid metal into an aqueous solution, and carrying out ultrasonic dispersion to obtain dispersion liquid; s2, adding the dispersion liquid into a sodium alginate solution, and performing ultrasonic treatment to obtain a sodium alginate-coated liquid metal aqueous solution; s3, acrylamide is dissolved in deionized water, then the aqueous solution of the liquid metal wrapped by sodium alginate is added, then a cross-linking agent, an initiator and MXene are added, and the mixture is stirred to be uniform; and S4, pouring into a mold, and heating to form the hydrogel. The composite hydrogel material prepared by the invention has the advantages of high stretch rate, strong electromagnetic shielding performance and the like, and can be used as electronic skin for electromagnetic shielding, human health monitoring, man-machine communication and soft robots.

The invention belongs to the technical field of hydrogel, and particularly relates to animal glue composite hydrogel as well as a preparation method and application thereof. The animal glue composite hydrogel comprises animal glue, polyvinyl alcohol, glycerol and water. The animal glue composite hydrogel provided by the invention not only has rheological and mechanical properties similar to those of natural nucleus pulposus, adapts to the mechanical environment of intervertebral discs, but also has tissue adhesion, can be adhered to soft tissues and avoid leakage, and also can inhibit lipid peroxidation of nucleus pulposus cells in the reactive oxygen species (ROS) environment, reduce cell ferroptosis and promote nucleus pulposus repair.

The invention relates to the field of biomedical materials, in particular to a composite hydrogel microsphere with excellent cell adhesion performance and a preparation method and application thereof, and the preparation method comprises the following steps: (1) modifying silk fibroin with glutathione to obtain sulfydryl modified silk fibroin SF-GSH; (2) adopting methacrylic anhydride as a double-bond introduction reagent, introducing a methacrylate group on hyaluronic acid and forming a carbon-carbon double bond to obtain double-bond modified hyaluronic acid HA-MA; (3) mixing the sulfydryl modified silk fibroin SF-GSH with double bond modified hyaluronic acid HA-MA, and adding lactobionic acid to prepare a composite hydrogel microsphere precursor solution; and (4) preparing the composite hydrogel microsphere precursor solution into the composite hydrogel microsphere containing lactobionic acid. Compared with single hyaluronic acid hydrogel, the composite hydrogel microspheres prepared by the preparation method provided by the invention have good biocompatibility.

The invention relates to curcumin-loaded pectin sodium alginate gel as well as a preparation method and application thereof, and belongs to the technical field of gel preparation. The preparation method of the curcumin-loaded pectin sodium alginate gel comprises the following steps: in a dark environment, stirring and mixing curcumin, arjunic acid, ortho-aminophenol and an organic solvent, adding a polyvinyl alcohol aqueous solution, a sodium alginate solution and a pectin solution, uniformly mixing, performing ultrasonic treatment, adding calcium chloride, stirring and mixing, performing ultrasonic treatment, and performing vacuum drying to obtain the curcumin-loaded pectin sodium alginate gel. And adding oxidized hyaluronic acid, continuously stirring, stirring at normal temperature until the organic solvent is completely volatilized, and cleaning the hydrogel with deionized water to obtain the hydrogel. According to the invention, calcium ions and sodium alginate are subjected to physical crosslinking, pectin and polyvinyl alcohol are combined to form a composite hydrogel layer, the compounding of multiple components can effectively control the dissolution and drug release behaviors of active components, the bioavailability of curcumin is increased, the compactness and stability of hydrogel are increased, and the bioavailability of curcumin is improved. The oxidation resistance of the hydrogel can be effectively improved.

The present invention relates to the field of biomedical materials. Particularly provided is a DNA-silk fibroin composite hydrogel microsphere. The DNA-silk fibroin composite hydrogel microsphere is prepared from DNA and silk fibroin on the basis of the micro-fluidic technology by means of combination of self-assembly physical crosslinking and photo-crosslinking. The introduction of a silk fibroin network into the composite hydrogel microsphere can provide mechanical performance for a DNA hydrogel network and reduce the production cost. RGD can remarkably improve the cell loading capability of the microsphere. The hydrogel microsphere can simulate a microenvironment of cartilage tissue by means of three-dimensional loading of high-density cells, so as to enhance substance exchange and signaling between cells, and more effectively promote the proliferation and adhesion of bone marrow mesenchymal stem cells and regulating the chondrogenic differentiation, thus promoting cartilage regeneration and repair, and providing an available material for preparing medicaments or medical instruments for cartilage defect repair.

The invention relates to nanoparticle-loaded antibacterial composite hydrogel as well as a preparation method and application thereof, a hydrogel network main body is formed by grafting phenylboronic acid to methacrylated I-type collagen rCol1MA-PBA and methacrylated polylysine EPLMA and adding glucose oxidase GoX for crosslinking, and is loaded with core-shell nano-enzyme C (at) Z (at) T at the same time, and the core-shell nano-enzyme C (at) Z (at) T is loaded with the core-shell nano-enzyme C (at) Z (at) T and the core-shell nano-enzyme C (at) Z (at) T; the core-shell nano-enzyme C (at) Z (at) T is composed of a spherical CeO2 nano-particle core, a zeolite imidazate framework material TIF-8 shell and tannic acid TA coating the shell. The raw materials of the hydrogel are easy to obtain, the preparation method is simple, the price is low, and the components are safe and reliable; in addition, multiple functions of resisting bacteria, resisting inflammation, resisting oxidation, promoting angiogenesis and the like are integrated, a more comprehensive treatment effect is provided, and the dressing can be used for healing the wound surface of diabetes mellitus.

The invention provides a preparation method of a cell culture three-dimensional scaffold and cell culture meat, which comprises the following steps: firstly, preparing a gelatin-carrageenan mixed solution and a gel precursor solution of transglutaminase, dividing into two parts, incubating at constant temperature to obtain two parts of composite hydrogel, randomly freeze-drying one part to obtain aerogel, and freeze-drying the aerogel to obtain the cell culture three-dimensional scaffold. Stacking on the other part and incubating at constant temperature again to obtain the prefabricated double-layer gel. The prefabricated double-layer gel is directionally frozen, ice crystals grow upwards from the bottom, freezing is stopped after the temperature is reduced to the set temperature, and the cell culture three-dimensional scaffold is obtained through drying. The stent adopts an ordered-disordered partition design, parallel micro-channels are formed in the lower layer by using a directional ice template method, and muscle fiber arrangement is simulated; a porous spongy structure is constructed on the upper layer by using a random ice template method, and is adapted to adipocyte proliferation. Two layers of interfaces are interpenetrated and communicated, natural mechanical gradients are combined, natural tissue characteristics are re-engraved, the traditional limitation is broken through, the cell co-culture efficiency and the cultured meat quality are improved, and industrialization is promoted.

The invention discloses light self-repairing concrete and a preparation method thereof, and relates to the technical field of concrete. The method comprises the following steps: firstly, efficiently packaging a calcium nitrate solution in hollow glass beads by utilizing a negative pressure impregnation technology; then growing a porous zeolite crystal coating on the surface of the microbead in situ by adopting a sol-gel method to form a self-repairing filler with a core-shell-hole gradient structure; when the concrete cracks to cause the cracking of the microbeads, the Ca < 2 + > in the cavity is quickly released, and the Ca < 2 + > adsorbed in the zeolite layer is gradually dissociated along with water permeation, so that the new microcracks are continuously repaired. Then, uniformly coating the surface and pores of the carboxymethyl cellulose hydrogel network with polydopamine in an in-situ oxidative polymerization manner to form composite hydrogel with photo-thermal responsiveness; lighting and heating to trigger dynamic coordination bond dissociation; meanwhile, heat drives rapid directional crystallization of a repair product by promoting the ion diffusion rate, and a compact mineralization layer is formed. The concrete prepared by the invention has the effects of light weight and self-repairing.

The invention relates to the technical field of hydrogel, in particular to a preparation method and application of EGCG-mediated hydrogel, a lysozyme solution is heated under the acidic condition to form lysozyme amyloid fibrils LAFs, EGCG is dissolved in a buffer solution and mixed with the LAFs solution obtained in the step 1 in proportion to form an LAFs-EGCG compound, and the EGCG-mediated hydrogel is prepared. The chitosan CS is dissolved in an acetic acid buffer solution, glutaraldehyde is added to serve as a cross-linking agent, the mixture is mixed with the LAFs-EGCG compound obtained in the step 2 and stirred, the composite hydrogel is formed, the concentration of EGCG is 0.2-1.0 wt%, the concentration of LAFs is 5 wt%, the concentration of chitosan is 2 wt%, the pH value of the lysozyme solution in the step 1 is 2.0, the heating temperature is 77 DEG C, the heating time is 10 hours, the concentration of EGCG in the step 2 is 0.4-0.8 wt%, and the pH value of the lysozyme solution in the step 2 is 1.5-2.5. In the step 3, the concentration of glutaraldehyde is 2%, the storage modulus G'of the hydrogel is 325-480 Pa, the hardness is 2176.71 g, and the bacteriostasis rate on staphylococcus aureus and salmonella exceeds 95%.

The invention belongs to the technical field of intelligent high polymer materials, and particularly relates to a preparation method of a quick temperature-sensitive response poly (N-isopropylacrylamide) (PNIPAM)-polyacrylamide (PAM) composite hydrogel. The method comprises the following steps: firstly, copolymerizing carboxymethyl cellulose and N-isopropylacrylamide to obtain a graft polymer, and then reacting the graft polymer with acrylamide to obtain the CMC-PNIPAM-PAM composite hydrogel. The preparation method is low in raw material price and simple and feasible in technological process; the prepared material is rapid in response to temperature change, and the hydrogel is rapidly and reversibly changed from transparent to opaque in the heating process. Besides, by changing the temperature condition in the hydrogel preparation process, the size stability of the hydrogel in the temperature response process can be changed, two kinds of hydrogel with large performance difference are obtained, potential application risks caused by performance failure and structure instability of a gel device in different application environments are avoided, and the application performance of the gel is further improved.

The invention discloses a method for preparing a methylacryloyl chitosan / gelatin-based hydrogel wound dressing through 3D printing and application, and relates to a method for preparing a hydrogel wound dressing and application. The problems that existing MXene is high in photo-thermal conversion temperature, and bacteria rapidly breed again after near-infrared irradiation is closed are solved. The ZGC composite hydrogel wound dressing integrates multiple functions, can simultaneously realize hemostasis, antibiosis, anti-inflammation, vascularization promotion and cell regeneration, and is especially suitable for infectious wounds. The antibacterial performance can be achieved under the activation of near-infrared light through the dual effects of a photothermal therapy and a photodynamic therapy, and meanwhile, the antibacterial effect can be achieved in cooperation with Zn < 2 + >. The ZGC composite hydrogel wound dressing can be accurately customized and printed through a 3D printing technology according to the shape and depth of a wound, the composite dressing can achieve accurate low-temperature photo-thermal treatment, meanwhile, the continuous release of Zn < 2 + > and the physical antibacterial function of MXene are maintained, normal tissue is protected while bacteria are killed, and the healing rate of an infected wound is remarkably increased.

The invention relates to the field of biomedical materials, in particular to composite hydrogel as well as a preparation method and application thereof. The composite hydrogel prepared by the invention realizes step-by-step release and time sequence regulation of a polypeptide drug through the combined action of Gel-PBA and GelMA: the anti-inflammatory peptide (Ac2-26) is quickly released under the conditions of high ROS and low pH, so that inflammation and pyroptosis are reduced; osteogenic peptide (OGP) is continuously and slowly released, and osteogenic differentiation is promoted. The step-by-step release mechanism of the anti-inflammatory peptide and the osteogenic peptide can realize accurate drug release, and is helpful for synergistically regulating inflammation and promoting bone regeneration. The composite hydrogel is used as a biological medicine material, can realize timely anti-inflammatory effect and long-term osteogenesis in a complex pathological environment such as diabetic periodontitis, and has a good application prospect.

The invention provides milk exosome composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The milk exosome composite hydrogel provided by the invention is prepared from milk exosome, hyaluronic acid, epsilon-polylysine, 3-aminophenylboronic acid and tannic acid. The exosome is extracted from milk of a non-stem cell source; the molecular weight of the hyaluronic acid is 200 to 400 KDa. The invention provides a hydrogel carrier capable of loading a large amount of milk exosomes, and the hydrogel carrier can continuously release a large amount of milk exosomes and can give full play to the anti-oxidation and inflammation inhibition effects of the milk exosomes. In the aspect of wound healing, the milk exosome and the hydrogel carrier have a synergistic effect, so that the healing effect can be remarkably improved, and the healing period is shortened.

The invention discloses a solar interface evaporator and a preparation method and application thereof. The evaporator comprises a porous cellulose supporting layer and a photo-thermal composite hydrogel layer loaded on the cellulose supporting layer, and the porous cellulose supporting layer and the photo-thermal composite hydrogel layer are combined in a gel in-situ cross-linking mode to form an integrated composite structure. The photo-thermal composite hydrogel layer is composite hydrogel formed by cross-linking polyvinyl alcohol, chitosan quaternary ammonium salt and carbon black. The preparation method comprises the following steps: adding polyvinyl alcohol and chitosan quaternary ammonium salt into a solvent to form a transparent mixed solution, adding the carbon-based photothermal conversion material, and continuously heating and stirring to prepare a hydrogel precursor solution; then adding glutaraldehyde and hydrochloric acid, and carrying out cross-linking reaction to form a hydrogel system; and immersing the cellulose sponge, standing, circularly and alternately freezing and unfreezing, and finally freeze-drying to obtain the product. The evaporator disclosed by the invention integrates highlight absorption, high heat utilization, water transportation, salt resistance and antibiosis, can realize large-scale production, and is suitable for scenes such as seawater desalination, sewage purification and emergency water supply.

The invention discloses a preparation method and application of high-strength, high-inorganic-ratio and degradable organic-inorganic composite hydrogel, and belongs to the technical field of biomedical tissue engineering. The hydrogel is prepared from the following components in percentage by weight: 30 to 70 percent of calcium phosphate nano-cluster and 30 to 70 percent of sodium alginate. The organic-inorganic composite hydrogel is beneficial to proliferation and mineralization of bone cells, and more ideal bone guidance is realized. Experimental results prove that the material has good cytocompatibility, can quickly promote rat skull defect repair (8 mm limit bone injury repair time is shortened to 4 weeks), and has a more remarkable healing effect compared with a contrast autogenous bone graft material with an optimal clinical repair effect. The high-strength organic-inorganic composite hydrogel prepared by the invention is of a single-network structure, shows good mechanical properties, also has excellent degradability matched with tissues, and is beneficial to hard tissue repair.

The invention discloses multifunctional hydrogel for promoting healing of diabetic wounds and a preparation method of the multifunctional hydrogel. The multifunctional hydrogel is prepared from Ti3C2Tx-Ag, paeoniflorin (PF), a gel matrix oxidized konjac glucomannan (OKGM) solution and carboxymethyl chitosan (CMCS). The method comprises the following steps: mixing Ti3C2Tx powder with AgNO3 in deionized water, heating to boiling, adding a proper amount of a sodium citrate solution, reacting to obtain Ti3C2Tx-Ag (TA) powder, and mixing the powder with a paeoniflorin (PF) and oxidized konjac glucomannan (OKGM) solution and a carboxymethyl chitosan (CMCS) solution to prepare the KC-PF-TA hydrogel. The multifunctional hydrogel has excellent photo-thermal antibacterial performance, anti-inflammatory performance and angiogenesis promoting performance, shows a remarkable effect of promoting healing of diabetic wounds through the synergistic effect of Ti3C2Tx-Ag and paeoniflorin, and has good biocompatibility; the multifunctional nano-composite hydrogel disclosed by the invention has great application prospect and value in the field of wound repair materials.

According to the method, a one-pot copolymerization method is adopted, MBAA and borax serve as cross-linking agents, zwitterionic polyelectrolyte hydrogel containing SBMA, PVA, THMA and AMPS is prepared, and the zwitterionic polyelectrolyte hydrogel has excellent adhesion performance and biocompatibility and is suitable for the field of biological medicine. According to the method, the physical characteristics of the hydrogel are enhanced due to crosslinking sites and hydrogen bonds of polyvinyl alcohol. The cationic and anionic groups of SBMA improve the adhesion performance, and the reaction monomer THMA provides hydrogen-bond interaction to further promote adhesion, so that the prepared hydrogel adhesive shows excellent adhesion performance and biocompatibility, and is suitable for biological medicine application of wound dressing, drug release systems, tissue engineering and the like.

The invention discloses a phosphorus removal adsorbent based on micro-nano air flotation coupling micro-flocculation and a preparation method thereof, and the preparation method comprises the following steps: dissolving carboxymethyl chitosan, mixing with modified hydroxyapatite and a hydrophobic MOF polymer, and polymerizing under the action of an initiator to obtain composite hydrogel; curing the composite hydrogel in a calcium chloride solution, and performing circulating freezing-unfreezing physical crosslinking to obtain the phosphorus removal adsorbent. The organic phosphorus adsorbent and the inorganic phosphorus adsorbent are combined, the phosphorus adsorption capacity of the phosphorus removal adsorbent is enhanced, the hydrophobic MOF polymer with the adsorption effect on hydrophobic new pollutants is uniformly compounded with the organic phosphorus adsorbent, the phosphorus removal adsorbent also has the adsorption effect on insoluble new pollutants in wastewater, and the phosphorus removal adsorbent has the adsorption effect on insoluble new pollutants in wastewater. Under the synergistic effect of the micro-nano air flotation technology, new pollutants adsorbed by micro-nano air flotation are adsorbed by the phosphorus removal adsorbent, and the problems that the binding force of micro-nano air flotation to the new pollutants is low, and the new pollutants are prone to falling off are solved.

The invention discloses a photo-thermal composite hydrogel patch and a preparation method and application thereof.The hydrogel patch is of a three-dimensional latticed porous structure formed by taking methylacryloyl gelatin (GelMA) and methylacryloyl hyaluronic acid (HAMA) as matrixes, loading niobium carbide nano-particles (Nb2CNPs) and vinipofen (VP) and conducting 3D printing or casting molding, the hydrogel patch is named as VP-Nb2C-coated GelMA / HAMA (VNGH) hydrogel patch for short. The VNGH has good photo-thermal antibacterial property, oxidation resistance and reepithelization promoting function, can significantly improve the quality of mouse diabetic wound healing, and provides a new thought and strategy for realizing scar-free healing of diabetic wounds.

The invention provides a photo-thermal evaporation material based on black titanium dioxide as well as a preparation method and application of the photo-thermal evaporation material. The preparation method comprises the following steps: mixing urea, absolute ethyl alcohol and tetrabutyl titanate into a solution A, mixing absolute ethyl alcohol, ultrapure water and hydrochloric acid into a solution B, dropwise adding the solution B into the solution A, mixing to form a white colloid, heating in a water bath, drying, and calcining in a nitrogen atmosphere to obtain black titanium dioxide powder; the preparation method comprises the following steps: fully mixing a certain amount of black titanium dioxide, sodium alginate and ultrapure water to form a uniform dispersion liquid, dipping the pretreated polyurethane sponge in the dispersion liquid, and crosslinking with a calcium chloride solution to prepare the photo-thermal evaporation material of the black titanium dioxide-calcium alginate composite hydrogel. The photo-thermal evaporation material breaks through the photo-thermal application bottleneck of traditional titanium dioxide, has excellent evaporation rate and seawater desalination performance, and can effectively remove various printing and dyeing wastewater to obtain clean water.