The invention relates to the technical field of fluorescent contrast agents, in particular to a preparation method of a
melanin-like nanocapsule fluorescent probe based on
lung injury detection. The nanocapsule type fluorescent probe is a
melanin-like nanocapsule type fluorescent probe with a hollow structure. According to the method for preparing the
melanin-like nanocapsule type fluorescent probe, the biocompatible polydopamine nanocapsule can be simply and efficiently prepared, and polydopamine has a
chemical structure similar to melanin, has good
biocompatibility / biodegradability, low toxic and side effects and controllable size, is easy to mark by near-
infrared fluorescent dye, and can be used for preparing the melanin-like nanocapsule type fluorescent probe. And the method can be used as an effective strategy for
curative effect monitoring. Besides, based on a unique hollow structure, the
self weight of the polydopamine
capsule is obviously reduced, and the polydopamine
capsule is relatively stable in an
aqueous solution, uniform in size and good in
dispersity, and has a good prospect in the field of
fluorescence imaging.