48 results about "Biocoating" patented technology

The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality.

Biosensor components (chips) are described based on direct biocoating processes that result in the tenacious and stable, noncovalent (believed to be chemisorptive) binding of anchor substances such as avidin(s) other proteins having specific binding partners or oligo- or poly-nucleotides onto any piezo-electrically active crystal surface. The resulting platform technology can be developed for a variety of biosensors with specific applications in biological assays. The table mono layers of the anchor substances forms reactive layers, ready to bind a capture reagent such as a biot-inylated antibody for capture and detection of analytes in biologic fluid samples. Although the processes described herein can be performed on any type of piezoelectric material in any number of configurations, some embodiments are directed to a biosensor with the foregoing biocoating onto a particular acoustic plate mode biosensor and where the interdigitated transducers (IDTs) are present on the opposite side of the crystal's biocoated film.

The invention provides a nano hydroxyapatite coating and a preparation method thereof and an electrostatic atomization device, belonging to the technical field of medical biological coating. The coating has the following components in weight percent: 10-30% of silk fibroin and 70-90% of nano hydroxyapatite. The preparation method is as follows: firstly carrying out degumming process and dissolving process to obtain the silk dissolving liquid; preparing into the suspending liquid of silk fibroin-nano hydroxyapatite composite precipitate; washing to neutrality by deionized water to prepare intoprecursor solution; and adopting the electrostatic atomization sedimentation method to lead the precursor solution to be coated on the substrate in atomizing form to prepare into nano hydroxyapatite composite material biological coating. The invention can prepare the silk fibroin/nano hydroxyapatite coating with compact accumulation and no cracks, and the shape thereof can be controlled.

The invention discloses a sealing structure of an artificial cochlear implant and a packaging technology thereof, the sealing structure comprises: a circuit and a chip, which is characterized in that the circuit is arranged on a circular thin-sheet base plate, a welding ring and a contact point which is electrically connected with the circuit are arranged on the base plate, a connecting ring is annular and fixedly connected with the base plate; the chip is welded on the circuit; an upper end cover and a lower end cover are arranged outside the base plate, the upper end cover, the lower end cover and the welding ring are fixedly connected to form a sealing outer shell; the packaging technology specifically comprises that: the circuit, the welding ring and the base plate are sintered to a whole body by ceramics; the welding chip uses a biological coating layer to carry out the first packaging; the upper end cover and the lower end cover are produced to carry out the second packaging of the implant; and a biological silicon rubber is used for carrying out the third packaging of the upper end cover and the lower end cover. The sealing structure has simple structure, compared with the prior art, the reliability and the safety of the implant can be greatly improved, which can have great strength and toughness, prevent the collision and the seepage and ensure long-term normal work of the implant circuit in the human body.

The invention discloses a medical nano bio-coating and a preparation process thereof. The bio-coating is prepared through the following raw materials of nano-hydroxyapatite, tetracalcium phosphate, graphene quantum dots, strontium monophosphate, dopamine, calcium fluoride, magnesium fluoride, barium ditantalum hexaoxide, silver nitrate, gelatin, ammonium bicarbonate, polyethylene glycol, silk fibroin and phosphohumate. The bonding strength between the bio-coating provided by the invention and a substrate is high; meanwhile, the tenacity is improved, and the deficiency of large brittleness of traditional hydroxyapatite is overcome; and in addition, the bio-coating has good biocompatibility, capable of promoting adherency and growth of bone cells, increasing the repairing and healing rate and shortening the healing period, and good in application and popularization value.

There is described an implant comprising: (a) a bone engaging portion positioned at the distal end of the implant, said bone engaging portion comprising: a longitudinally extending distal portion; and an adjoining region positioned at the proximal end of the longitudinally extending distal portion; (b) a transmucosal portion positioned at the proximal end of the adjoining region; and (c) an abutment portion positioned at the proximal end of the transmucosal portion, wherein the exterior surface of the longitudinally extending distal portion comprises a conformal microscale cell structure and optionally, a non-biological coating; wherein the exterior surface of the abutment portion is polished, suitably, to a mirrored or super mirrored finish and/or wherein the exterior surface of the abutment portion has an R_a of between about 1 and about 3 um; wherein the exterior surface of the adjoining region comprises a roughened surface, suitably with an R_a of between about 5 and about 30 um; and wherein the exterior surface of the transmucosal portion comprises a plurality of micro holes.

The invention discloses a method for preparing a continuous gradient biological coating by utilizing suspension plasma spraying. A calcium silicate/fluorohydroxyapatite continuous gradient biologicalcoating is prepared on the surface of a titanium or titanium alloy matrix by utilizing a suspension plasma spraying method. The high bonding strength between a calcium silicate coating and the titanium matrix and the low solubility of fluorohydroxyapatite are utilized, solid phase components of a mixed solution are gradually changed by adjusting the liquid feeding rates of two suspensions, the continuous gradient coating is prepared on the surface of the titanium or titanium alloy matrix by adopting a suspension plasma spraying technology, namely, the calcium silicate is arranged at the bottomof the coating, the fluorohydroxyapatite is arranged at the top of the coating, gradient component transition is achieved between the top and the bottom, the internal stress of the coating can be greatly reduced through gradient design, and the sensitivity at an interface is reduced. The binding force between the calcium silicate/fluorohydroxyapatite gradient coating and the titanium matrix is obviously improved, the dissolution rate is obviously reduced, and the coating shows good biological activity and antibacterial activity.

The invention provides a biological coating based on cyclomatrix-type polyphosphazene and a preparing method thereof. Phosphonitrilic chloride trimer and a polyfunctional group functional monomer containing an amino group and a hydroxyl group are dissolved into organic solvent, then a material to be modified is placed into a solution, an acid-binding agent is added, and the cross-linking reaction is carried out to obtain the coating modified by cyclomatrix-type polyphosphazene. The polyphosphazene coating technology is a method which is easy to realize and improves traditional macromolecule biocompatibility and corrosion resistance of metal alloy equipment, and the method is expected to play a role in the field of clinical medicine and biological scaffolds.

The invention relates to a preparation method of a strong-binding-force biological coating on the surface of a carbon/carbon composite material. The method comprises the following steps: firstly, directionally arranging carbon fibers in an orthogonal direction on the surface of the carbon/carbon composite material; firstly, preparing carbon fibers, then introducing hydroxyapatite nanobelts into pore structures of the carbon fibers by virtue of a titration method, then introducing the hydroxyapatite nanobelts again by virtue of resin, and in addition, attaching the resin to the surfaces of thehydroxyapatite nanobelts and filling gaps with the resin, so as to finally form the biological coating composed of the orthogonally arranged carbon fibers, hydroxyapatite nanobelts and resin. The maximum value of the interface bonding force between the prepared biological coating and the carbon/carbon composite material is 19.80 MPa, and the interface bonding force is improved by 37.8% compared with the maximum value of the interface bonding force reported in the background technology.

The invention discloses a preparation method for a medical metal-based biocoating, and belongs to the field of metal coating material synthesis. According to the method, the surface of magnesium alloy is cleaned and degreased with acetone, after honey is coated, the magnesium alloy is soaked in seawater and secondary sedimentation tank activated sludge, and microorganisms and algae in seawater and sludge are catalyzed to invade into the surface of the magnesium alloy for growth corrosion through sunlight exposure; and after drying sintering, components which is rich in hydroxyl and facilitates crystallization of hydroxylapatite are formed on the surface of the magnesium alloy, in the electrophoretic deposition process, a substrate and the coating are chemically bonded, the interface bonding strength is greatly improved, and finally the medical metal-based biocoating is obtained through sintering. The biocoating is uniform in thickness, high in bonding force with the substrate and not prone to loosening and peeling off in the using process, and the service life is greatly prolonged.

The invention discloses a telecommunication base station biocoating. The biocoating is characterized in that the biocoating comprises, by weight, 35-52 parts of a plastic base material, 9-16 parts of elm chip, 19-20 parts of camphor wood chip, 6-12 parts of Chinese oak wood chip, 7-13 parts of trumpet shell powder, 6-7 parts of oyster shell powder, 10-29 parts of an interpenetrating network emulsion, 3-8 parts of an inorganic thickening agent, 4-8 parts of a flexibilizer, 5-13 parts of a fire retardant, 9-18 parts of mica powder having a laminated structure, 1-6 parts of nanometer calcium carbonate, 2-8 parts of ethylene-acrylate, 3-5 parts of high density polyethylene, 4-6 parts of talcum powder, 6-7 parts of liquid paraffin, 1-2 parts of cellulose, 1-2 parts of a foaming agent, 3-6 parts of pore-closed bead, and 1-2 parts of fly ash. The biocoating has the advantages of excellent heat insulation performance, low heat conduction coefficient, stable physical and chemical performances, ageing resistance and high temperature cracking resistance, can be used as a coating, and can also be put in a die to form a sheet after strickling, heating and baking.

The invention discloses a titanium alloy bone implant adopting a bio-coating structure and a preparation method of the titanium alloy bone implant. The titanium alloy bone implant comprises a titanium alloy matrix, a porous metal powder coating and a bio-coating, wherein the porous metal powder coating is uniformly distributed on the surface of the titanium alloy matrix and the bio-coating is uniformly distributed on the surface of the porous metal powder coating. The porous metal powder coating and the bio-coating are designed on the implant, multiple pores are formed in the surface of the implant by the aid of the porous metal alloy coating, the bio-coating enters the pores during coating to form closer connection between coatings, the frozen bio-coating forms tiny pores, the bio-coating is made of a resistance-free and easy-to-absorb material, thus, adhesion, proliferation and differentiation of cells are facilitated, regenerated cell tissue can be tightly combined with the porous titanium alloy coating after the bio-coating is completely degraded, the adhesion of regenerated tissue and the implant can be improved, and rejection reactions can be reduced.

The invention discloses a new biological modification method of the surface of crystalline silicon. The method comprises the following steps: firstly dissolving an alkaline reagent in water to prepare an alkaline solution, and soaking the crystalline silicon in the prepared alkaline solution until the surface of the crystalline silicon forms a thin silicate colloid layer; then directly putting the crystalline silicon soaked by the alkaline solution in a simulated body fluid prepared in advance and soaking to form an osseous apatite bioactivity layer on the surface of the thin silicate colloid layer by inducement; and finally, repeatedly rinsing the prepared crystalline silicon with the thin silicate colloid layer and the osseous apatite bioactivity layer with water, and then drying to form a compound biological coating using the silicate as a transition layer and the osseous apatite as an outer layer on the surface of the crystalline silicon, namely a silicon-based silicate-osseous apatite compound biological coating is ultimately formed. The method has the advantages of convenient operation and low cost. Besides, the obtained biological coating on the surface of the crystalline silicon has favorable biological compatibility, and is difficult to fall off.

The invention relates to a hydroxyapatite nanorod biological coating and a preparation method thereof. The method comprises the steps: step 1, placing zinc or a zinc alloy in an aqueous solution of calcium acetate to be subjected to a hydrothermal reaction, and placing the aqueous solution of calcium acetate in a reaction kettle, wherein zinc or the zinc alloy is in contact with the bottom of thereaction kettle, and a zinc oxide nanorod coating is formed on the surface, in contact with the bottom of the reaction kettle, of the zinc or zinc alloy; adding an aqueous solution of NaOH into an aqueous solution of calcium salt and phosphate to form a mixed system A to enable the mixed system A to be alkaline, and putting the aqueous solution of calcium salt and phosphate into the reaction kettle; and step 2, placing the zinc or zinc alloy obtained in the step 1 in the mixed system A, placing the zinc oxide nanorod coating upward, performing hydrothermal treatment at 70-180 DEG C to form a hydroxyapatite nanorod biological coating which is firm in combination and good in biological activity on the surface of the zinc oxide nanorod coating. The hydroxyapatite nanorod biological coating isof great significance in development of the zinc alloy in repairing and replacing hard tissues and applying an implant.

The invention discloses a medical magnesium-based alloy material and a preparation method thereof. The medical magnesium-based alloy material comprises an alloy matrix and a biological coating. The alloy matrix comprises the following components in percentage by weight: 2.2-3.2% of Cu, 0.6-1.2% of Fe, 1.2-1.6% of Sb, 0.4-0.8% of Ta, 1.2-3.2% of Ca, 0.6-1.2% of V, 0.2-0.4% of Mo, 1.2-1.4% of Ag, 2.2-3.2% of P, 0.3-0.7% of Si, 0.02-0.04% of F, 0.1-0.3% of S, 5.2-6.4% of nano-hydroxyapatite, and the balance of Mg. The surface of the alloy matrix is polished to smooth the unsmooth surface caused by the nano-hydroxyapatite floating on the surface layer of the alloy matrix, and the polishing thickness is 1-3 [mu]m. The main materials of the biological coating are collagenous fibers and chitin. According to the invention, metal elements Cu, Fe and Sb are added, inorganic elements P, Si, F and S are jointly added, the nano-hydroxyapatite is added, the surface is polished, and then the surfaceis coated with the biological coating, so that the strength and biocompatibility of the alloy material are improved.

The invention discloses a method for preparing a tantalum bio-coating on the surface of magnesium and magnesium alloy, which is characterized by comprising the following preparation steps: 1) preparing a porous micro-arc oxidation ceramic coating on the surface of magnesium/magnesium alloy: suspending and immersing the magnesium/magnesium alloy into an electrolyte as an anode, taking a stainless steel electrolytic bath as a cathode, and performing micro-arc oxidation in a constant-voltage mode to prepare a porous micro-arc oxidation ceramic coating on the surface of the magnesium/magnesium alloy; the specific parameters are as follows: the voltage is 350-450 V, the power supply frequency is 800-1200 Hz, the positive and negative duty ratio is 30-50%, the treatment time is 2-10 min, and the electrolyte system comprises 0.5-2 g/L of tantalum powder, 2-5 g/L of sodium hexametaphosphate and 5-10 g/L of potassium fluoride; and 2) carrying out double glow plasma tantalum plating on the surface of the porous micro-arc oxidation ceramic coating to form a tantalum diffusion plating layer. According to the method, appropriate electrolyte components and micro-arc oxidation parameters are selected, the melting point of the ceramic coating prepared through micro-arc oxidation on the surface of the magnesium alloy can reach 1000-1500 DEG C, the increased surface temperature can provide a higher working temperature interval for double-glow ion tantalum plating, and therefore the coating thickness and the coating quality of double-glow ion tantalum plating are improved.

The invention provides an all built-in expandable biocoating spine anterior internal fixation system, relating to the technical field of medical devices. The all-built-in expandable biocoating spine anterior internal fixation system provided by the invention comprises a fastening nail, a nail core, a connecting rod and a plug screw, and a nano-hydroxyapatite-graphene coating and a nano-hydroxyapatite coating which are cooperated with each other coat the surfaces of the fastening nail, the nail core, the connecting rod and the plug screw, so that tissue compatibility of the fixation system is effectively promoted.