30 results about "Biocoating" patented technology

The invention relates to an orthopedic implant surface treatment method based on femtosecond laser. The surface treatment method comprises the following steps: cleaning and drying the surface of the orthopedic implant base material; femtosecond laser treatment is carried out on the surface of the orthopedic implant base material, and regularly arranged microstructures are formed on the surface of the base material; the orthopedic implant base material comprises a metal base material, a biological ceramic base material and a high polymer material base material, the microstructure comprises one or more of a groove, a dot matrix or a grid; and performing plasma spraying of a biological coating on the surface of the orthopedic implant base material subjected to femtosecond laser treatment to finally obtain the surface-modified orthopedic implant. Wherein the biological coating comprises a titanium coating and a hydroxyapatite coating. Compared with the prior art, the bonding force between the plasma spraying biological coating and the orthopedic implant base material is remarkably improved, and the application variety of the orthopedic implant base material is widened.

The invention discloses a method for coating a Ca-Cur submicron modified material-doped PLA layer on the surface of an Ag-DCPD film layer, and relates to the technical field of biological coatings on the surfaces of medical materials. The method comprises the following steps: manufacturing an LPBF-NiTi alloy matrix by adopting a laser powder bed melting additive manufacturing technology, and carrying out pretreatment on the LPBF-NiTi alloy matrix; the pretreated LPBF-NiTi alloy matrix is subjected to electrochemical deposition in an electrolyte solution, and the LPBF-NiTi alloy matrix with the deposited Ag-DCPD film layer is obtained; the preparation method comprises the following steps: dissolving CaCl2 and curcumin in absolute ethyl alcohol, putting the solution into a closed container filled with (NH4) 2CO3, and carrying out constant-temperature reaction to obtain a Ca-Cur submicron modified material; polylactic acid is dissolved in dichloromethane, then the Ca-Cur submicron modified material is dispersed in the dichloromethane, and a leaching solution is obtained; and the LPBF-NiTi alloy matrix on which the Ag-DCPD film layer is deposited is subjected to repeated dipping and pulling in the leaching solution, and the LPBF-NiTi alloy matrix coated with the Ag-DCPD / PLA / Ca-Cur composite film layer is obtained. According to the invention, the corrosion resistance, the biocompatibility and the antibacterial and anti-inflammatory performance of the Ag-DCPD film layer are successfully improved.

The present invention discloses an ultrasound-driven coating for promoting vascular tissue repair, and a preparation method and application thereof, which belongs to the technical field of medical biological coating materials. The present invention first dissolves a piezoelectric material and an anticoagulant in a solvent to obtain an electrostatic spinning solution, and obtains highly oriented nanofibers after spinning of the electrostatic spinning solution, and then obtains an ultrasound-driven coating for promoting vascular tissue repair after drying and annealing the nanofibers; this coating can respond to external ultrasonic signals to generate vibrations or electric fields; it has good biocompatibility and can be used to coat modified medical implant materials; the modified cardiovascular implant intervention device can effectively control the release of anticoagulants in time and space by adjusting the exogenous ultrasonic frequency, and trigger adjustable related stimulation signals, synergistically achieve anticoagulation and in situ endothelialization, effectively promote vascular tissue repair, and thus provide patients with personalized treatment plans.

The application provides a marine biological coating system and relates to the technical field of biological coating, and comprises an antirust epoxy primer and a polysiloxane connecting primer; the antirust epoxy primer is composed of the following components: epoxy resin 20%, antirust pigment 15%, auxiliary agent 15%, solvent 30% and curing agent 20%; the polysiloxane connecting primer is composed of the following components: polysiloxane resin 30%, antirust pigment 10%, auxiliary agent 15%, solvent 30%, curing agent 10% and antifouling agent 5%. The application optimizes the composition and preparation process of the coating, improves the weather resistance, salt mist resistance and corrosion resistance of the coating, and prolongs the service life of the coating.

The application discloses a kind of biological coating with physical mechanical antibacterial and chemical antibacterial performance and preparation method thereof, it is related to biomaterial technical field.The biological coating of the application is composed of TC4 nanofiber network and nano copper deposited in nanofiber network, and the preparation method is: using polishing-washing-sweeping process pretreatment TC4 titanium alloy;It is placed in alkali solution and heated in water bath to activate, and the alloy after activation is repeated polishing, washing, sweeping step, to obtain the substrate to be sputtered;The substrate is magnetron sputtered, and nano copper is deposited on its surface;After depositing nano copper, the substrate is annealed in inert atmosphere and cooled, and the biological coating with physical mechanical antibacterial and chemical antibacterial performance is prepared.The synergistic effect of the biological coating composed of nano copper and nanofiber network can effectively kill staphylococcus aureus, escherichia coli and other pathogenic microorganisms, and can be applied to oral implant, metal implant biomaterial as functional coating.

The invention relates to a bionic composite material and application thereof, the bionic composite material is an engineered cell membrane nanoparticle, the bionic composite material comprises a metal-polydopamine core and a biological coating, metal ions are chelated on the surface of a polydopamine nanoparticle to form the metal-polydopamine core, and the biological coating is coated on the surface of the metal-polydopamine core. The biological coating is a cell membrane extracted from macrophages which overexpress CXCR4, and the metal-polydopamine core is coated with the biological coating.

The application discloses a method for coating a PLA layer of Ag-DCPD film layer surface with doped Ca-Cur submicron modified material, and relates to the technical field of medical material surface biological coating. The method comprises the following steps: an LPBF-NiTi alloy base is manufactured by using a laser powder bed fusion additive manufacturing technology and is pretreated; the pretreated LPBF-NiTi alloy base is subjected to electrochemical deposition in an electrolyte solution to obtain an LPBF-NiTi alloy base with a deposited Ag-DCPD film layer; CaCl2 and curcumin are dissolved in anhydrous ethanol, and are placed in a sealed container containing (NH4)2CO3 for constant-temperature reaction to obtain Ca-Cur submicron modified material; polylactic acid is dissolved in dichloromethane, and then the Ca-Cur submicron modified material is dispersed in the polylactic acid to obtain a leaching solution; the LPBF-NiTi alloy base with the deposited Ag-DCPD film layer is repeatedly immersed and pulled in the leaching solution to obtain an LPBF-NiTi alloy base coated with an Ag-DCPD / PLA / Ca-Cur composite film layer. Through the method, the corrosion resistance, biocompatibility and antibacterial and anti-inflammatory performance of the Ag-DCPD film layer are successfully improved.

This invention provides a high-strength tibial support with osteoinductive properties and its preparation method. The preparation method involves preparing a reinforcing material and a matrix material; fabricating a multi-porous metal tibial support skeleton from a biodegradable metal material; placing the prepared multi-porous metal tibial support skeleton and the matrix material into a mold cavity; uniformly filling the pores of the multi-porous metal tibial support skeleton with the matrix material; and then pressing and molding the skeleton through the mold cavity. After pressing and molding, a semi-finished tibial support is obtained, which is then subjected to high-temperature sintering to obtain a high-strength tibial support with osteoinductive properties. This invention solves the technical problems of existing tibial support fixation methods using bone cement and bio-type fixation, which lead to bone cement particles easily entering the pulmonary circulation through the bloodstream and poor adhesion between the bio-coating and the prosthesis, resulting in coating detachment during embedding. This invention can be widely applied to the preparation of high-strength tibial supports with osteoinductive properties.

The present invention relates to a method for surface treatment of orthopedic implants based on femtosecond laser. The surface treatment method comprises the following steps: cleaning and drying the surface of the orthopedic implant substrate; performing femtosecond laser treatment on the surface of the orthopedic implant substrate to form regularly arranged microstructures on the substrate surface; wherein, the orthopedic implant substrate comprises a metal substrate, a bioceramic substrate and a polymer material substrate; the microstructures include one or more of grooves, dot matrices or grids; performing plasma spraying of a biological coating on the surface of the orthopedic implant substrate after femtosecond laser treatment to finally obtain a surface-modified orthopedic implant; wherein, the biological coating comprises a titanium coating and a hydroxyapatite coating. Compared with the prior art, the present invention significantly improves the bonding force between the plasma-sprayed biological coating and the orthopedic implant substrate, and broadens the types of applications of the orthopedic implant substrate.

The invention discloses a micro sewage purification robot based on an algal-bacterial symbiotic system and a preparation method of the micro sewage purification robot. The robot comprises a spiral carrier used for carrying the algal-bacterial symbiotic system, a swim-ring-shaped protective shell and a biological coating on the surface of the spiral carrier, and is characterized in that the section of the spiral carrier is of a star-shaped distribution structure, and the axis of the spiral carrier is hollow; microalgae are implanted into the spiral carrier; a fibronectin coating on which bacteria are attached is arranged on the surface of the spiral carrier; the device is provided with a swim ring-shaped protective shell. Through the design of the spiral carrier and the fibronectin coating, the attachment area and attachment firmness of bacteria on the carrier are increased, the pollutant decomposition efficiency of the algal-bacterial symbiotic system is improved, and the carrier has small resistance when moving in water; the protective shell structure prevents the carrier from being physically damaged, the service life of the robot is prolonged, meanwhile, the spiral carrier and the protective shell are formed by photocuring printing of degradable hydrogel materials, and environmental friendliness is achieved.

The invention belongs to the technical field of biological materials, and particularly relates to biological coating coated probiotics as well as a preparation method and application thereof. The biological coating in the biological coating coated probiotics is mussel mucin and sodium alginate, the final concentration of the mussel mucin in a coating system is 0.5-2 mg / mL, and the final concentration of the sodium alginate is 10-20 mg / mL. The biological coating coated probiotics disclosed by the invention has a wide application prospect in treatment of intestinal diseases such as intestinal colitis and the like. By targeting the inflammation part and enhancing the adhesion of the probiotics, the bioavailability of the probiotics can be effectively improved, the anti-inflammatory effect is synergistically exerted, and the intestinal microecological balance is maintained, so that a safe and effective new way for treating intestinal diseases is provided.

The present invention discloses a biomimetic nanomaterial, its preparation method, and application. The biomimetic nanomaterial comprises a degradable two-dimensional nanomaterial, a biomimetic biocoating with anti-nonspecific adhesion function bound to the two-dimensional nanomaterial, and a dendritic cationic polymer end-modified with alkyne groups, which is loaded onto the biomimetic biocoating. The biomimetic nanomaterial has the advantages of good tissue compatibility, systemic intravenous administration, high biosafety, simple operation, low cost, minimal toxicity and side effects, and good material stability.

This invention provides an eco-biocoating agent, a method for producing the same, and a slow-release fertilizer coated with the same on its surface. [Solution] By utilizing gellan gum and chitin / chitosan, the waste problem can be solved because it is biodegradable, has little environmental impact, and can be used as a substitute for plastic. Furthermore, it can be used in slow-release coating fertilizers, allowing the fertilizer components to be released gradually, thereby providing nutrients at the right time for the crops and ensuring the sustained effect of the fertilizer. In addition, the formed coating layer has excellent mechanical strength, high water resistance, and is firmly maintained even in the external environment. Moreover, it is harmless to the human body and can be used in various application fields such as food packaging materials, medical coatings, and biodegradable packaging materials.

A shaped body designed as a textile nonwoven, knitted textile, textile fiber, filtration membrane, film, floor covering, furniture component, part of a ship, container for fluids, piping element for fluids or granules and whose surface is partially or completely coated with a biocidal coating consisting of a carrier material of one or more polymers, one or more additives and 0.01 to 10 wt.% of a substance with the chemical composition Ce1-xMxO2-y, based on the total weight of the biocidal coating, or consisting of one or more polymers, one or more additives and 10-9 to 50 wt.-% of a substance with the chemical composition Ce1-xMxO2-y, based on the total weight of the molded body; wherein - M is selected from Ca, Ti, V, Fe, Sr, Zr and Nb; - x is a real number with 0 ≤ x ≤ 0.5; - y is a real number with 0 < y ≤ 0.4; characterized in that - the substance with the chemical composition Ce1-xMxO2-y consists of rod-shaped particles with a length of 50 to 800 nm, a cross-sectional area of ​​20 to 40 nm² and an equivalent diameter of 12 to 40 nm; and - a surface of the molded body contains particles with the chemical composition Ce1-xMxO2-y, wherein the particles are force-fitted to the molded body.

The invention provides a preparation method of a gradient biological coating with a controllable structure, which comprises the following steps: step 1, preparing uniformly mixed TC4 / HA powder by utilizing a low-energy ball milling method before coating deposition; 2, a TC4 / HA coating for relieving the thermal expansion coefficient is prepared on the surface of the titanium alloy through the atmosphere plasma spraying technology; and 3, preheating the base material deposited with the TC4 / HA transition layer, and preparing the HA biological coating with a controllable structure on the surface of the TC4 / HA coating.

The present invention belongs to the field of antimicrobial medical devices, and specifically relates to an antimicrobial biocoating, its preparation method, and its application. The present invention provides an antimicrobial biocoating comprising a porous photocrosslinked hydrogel and Saccharomyces boulardii, wherein the Saccharomyces boulardii aggregates and grows in the pores of the hydrogel. The antimicrobial biocoating provided by the present invention significantly inhibits the adhesion of Candida albicans to the surface of medical devices; under adverse conditions, the survival rate of Saccharomyces boulardii is higher; it reduces the risk of fungal infection caused by endotracheal intubation intervention, and also has an inhibitory effect on Escherichia coli and Staphylococcus aureus, and has a wide range of applications.

The invention belongs to the technical field of medical materials, and particularly relates to a coating with anticoagulation and endothelialization promotion functions and a preparation method and application thereof. In the preparation method of the coating, 2-methacryloyloxyethyl phosphorylcholine molecules are utilized to construct a bionic anti-fouling biological coating, a phosphorylcholine coating is prepared through a thermal initiation free radical reaction and a silane coupling agent polymerization reaction, and biological macromolecules and specific targeting functional polypeptides are introduced. The invention further discloses the coating prepared according to the method and application of the coating in preparation of surfaces of implanted and interventional instruments in contact with blood. The coating disclosed by the invention has a synergistic effect of double functions of anticoagulation and endothelialization promotion, and can be applied to cardiovascular intervention instruments such as artificial blood vessels, cardiovascular stents and left auricle occluders, so that the clinical requirement of long-term biocompatibility of the cardiovascular instruments is met.

Coated metal particles Coated metal particles 10 comprise a coating 14 derived from a molybdate solution that is reactive to the uncoated metal. Typically, the metal is aluminium or aluminium alloy.

The application discloses a door type nail, which comprises a body mechanism, an adjusting mechanism and an anti-rotor mechanism, the body mechanism comprises an arc-shaped body, a pair of base columns are installed at both ends of the arc-shaped body, and nail tips are fixedly connected to the lower ends of the pair of base columns; the adjusting mechanism comprises a rotating rod and a mounting groove, the mounting groove is horizontally and penetratingly arranged in the arc-shaped body, and the rotating rod is rotationally connected in the mounting groove. The elastic self-adaptive fitting of the anti-rotor mechanism can avoid the risk of bone necrosis caused by traditional rigid compression; the variable rigidity arc-shaped body realizes intelligent transition from early rigid fixation to medium elastic conduction, matches the biomechanical requirements in different stages of fracture healing; the biological coating and the micro barb structure cooperatively guide the directional climbing growth of bone tissue, realize the double locking of mechanical fixation and biological fusion; and the use effect of the door type nail is remarkably improved through the improvement of the door type nail, so the door type nail has good popularization value.

The application provides a high-strength hip cup with bone induction and a preparation method thereof. The preparation method comprises the following steps: preparing a reinforcing body material and a base material, preparing the reinforcing body material into a multi-filled porous metal hip cup framework, placing the prepared multi-filled porous metal hip cup framework and the base material into a cavity mold, uniformly filling the base material into the filling pores of the multi-filled porous metal hip cup framework in a shaking mode, then performing pressure forming on the uniformly mixed material through the cavity mold to obtain a hip cup semi-finished product, and placing the hip cup semi-finished product into a high-temperature oven to perform sintering, so as to obtain the high-strength hip cup with bone induction. The application solves the technical problems that the fixing mode of the existing hip cup adopts bone cement and biological fixation, bone cement particles are easy to enter into pulmonary circulation through blood circulation, the bonding force between a biological coating and a prosthesis is poor, and the coating is easy to fall off in the embedding process. The application can be widely applied to the preparation of hip cups.

The door-shaped nail comprises a body mechanism, an adjusting mechanism and a rotor wing preventing mechanism, the body mechanism comprises an arch-shaped main body, a pair of base columns are installed at the two ends of the arch-shaped main body, and nail points are fixedly connected to the lower ends of the pair of base columns; the adjusting mechanism comprises a rotating rod and a mounting groove, the mounting groove is formed in the arch-shaped body in a transverse penetrating mode, and the rotating rod is rotationally connected into the mounting groove. Through the elastic self-adaptive attachment of the anti-rotor wings, the osteonecrosis risk caused by traditional rigid compression is avoided; the variable-rigidity arch-shaped main body realizes intelligent transition from early-stage rigidity fixation to middle-stage elastic conduction, and is matched with biomechanical requirements of different stages of fracture healing; the biological coating and the micro-barb structure cooperate to guide the bone tissue to directionally climb and grow, so that double locking of mechanical fixation and biological fusion is realized; therefore, by improving the door-shaped nail, the use effect of the door-shaped nail is remarkably improved, and the door-shaped nail has good popularization value.

The present invention relates to a process for preparing a coating lacquer comprising the following steps: a) providing a natural hydrocolloid and a solvent, the solvent comprising or consisting of water, b) introducing, under stirring, the natural hydrocolloid into the solvent to obtain a pre-hydrolysis solution, the natural hydrocolloid having a concentration ≥ 13% by weight of the total weight of the pre-hydrolysis solution, c) reaching a temperature comprised between 40°C and 57°C, d) introducing a hydrocolloid-specific hydrolyzing enzyme to obtain a coating lacquer, wherein the coating lacquer has a natural hydrocolloid concentration ≥ 13% by weight of the total weight of the coating lacquer.

A multifunctional 3D printed bone plate for pelvic repair, which relates to the field of medical devices; its structure includes a main body part, a hollow filling block, fixing holes, an acetabular bone grafting part and an extension plate. A number of fixing holes are provided inside both the main body part and the extension plate. The left part of the main body part is connected to the hollow filling block, the bottom of the main body part is connected to the left side of the acetabular bone grafting part, and the right side of the acetabular bone grafting part is connected to the top of the extension plate. The manufacturing method of the present invention includes scanning CT images, establishing an integrated bone plate model, 3D printing the bone plate, and coating a biological coating. The multifunctional 3D printed bone plate for pelvic repair of the present invention is an integrated bone plate that combines the functions of a bone plate, a surgical guide plate and bone grafting, and can simultaneously achieve the effects of positioning, bone connection and bone grafting. The hollow part can achieve the bone grafting function and promote the healing of fractures, bone cracks and bone tissue defects. The manufacturing method of the present invention can create personalized bone plates.

The invention relates to the technical field of biological coating preparation, in particular to a calcium-phosphorus coating preparation method and system.The method comprises the steps that a to-be-treated base body in a coating preparation environment is pretreated, a pretreated base body is obtained, a coating base material set is used for obtaining calcium-phosphorus precursor slurry, and the calcium-phosphorus precursor slurry is prepared; the method comprises the following steps: carrying out laser melting on a pretreated matrix and calcium-phosphorus precursor slurry to obtain a molten calcium-phosphorus layer, carrying out cooling crystallization on the molten calcium-phosphorus layer to obtain a target coating, carrying out quality detection on the target coating to obtain a detection result, if the detection result is unqualified, obtaining an abnormal type, and carrying out adjustment preparation on the target coating based on the abnormal type. And if the detection result is qualified, taking the target coating as the qualified coating. According to the invention, the high efficiency and stability of preparation of the calcium-phosphorus coating can be improved.

The invention discloses a marine environment concrete anti-corrosion construction method which comprises the following steps: S1, constructing a transmission channel and a transition layer: coating the surface of concrete with an inner porous interface agent to form the transition layer; s2, coating of an active biological coating: coating the transition layer with a biological composite repairing agent to form the active biological coating; the biological composite repairing agent comprises the following components in percentage by weight: 10%-15% of a spore mixture of cyanobacteria and mineralized bacteria, 40%-60% of a biological binder, 4%-6% of nanofibers, 2%-3% of a light stabilizer, 2%-5% of modified attapulgite powder, 0.5%-2% of anhydrous calcium chloride powder and the balance of water, s3, activation and symbiosis: after the active biological coating is coated, a nutrient solution is sprayed, illumination is provided, cyanobacteria and mineralized bacteria are induced to be activated and propagated, a symbiosis system is formed, a biomimetic mineralized skin protection layer is formed, and therefore long-acting, economical and integrated anti-corrosion and anti-abrasion protection of the marine concrete structure is achieved.

This invention discloses a method for integrating and optimizing the arterial filtration function of a membrane oxygenator, relating to the field of membrane oxygenator technology. The method includes the following steps: setting performance target parameters for an integrated membrane oxygenator; using a dynamic tension control process to wind gas exchange membrane fibers around its periphery to construct a temperature-changing unit and an oxygenation unit; during the winding process in step S2, placing multi-layer filter screens at preset positions to construct multi-layer filter screens between the gas exchange membrane fiber layers; using a centrifugal potting process to inject encapsulation material into the end of the component, curing it in one step to form a sealed end that isolates the blood phase, gas phase, and water phase; introducing a biomimetic coating solution into the molded blood channel to construct a biocompatible coating on the substrate surface; performing performance tests on the finished product and comparing it with the performance target parameters in S1; adjusting the process parameters of at least one step from S2 to S5 based on deviation feedback until the product meets the standards; this invention ensures the consistency and compliance rate of product performance.

This invention relates to the field of marine anti-corrosion materials technology, specifically to an underwater curing anti-corrosion and anti-biological coating and its preparation method. The coating comprises an adhesive layer and an anti-biological layer. The adhesive layer, by weight, comprises the following raw materials: 50-60 parts epoxy resin, 1-3 parts modifier, 7-15 parts diluent, 4-10 parts amino silicone resin, 10-15 parts glass powder, 3-5 parts silica, 2.5-7.5 parts silane coupling agent, 0.2-0.5 parts defoamer, and 25-30 parts curing agent. The anti-corrosion coating prepared by this invention has the advantages of high bonding strength, easy maintenance, good corrosion resistance, long service life, and does not pollute the environment.

The utility model discloses a high strength wear -resisting cable for warship relates to warship equipment and marine engineering technical field. The high strength wear -resisting cable for warship, the stress dispersion effect of carbon nanotube, aramid twisted structure and graphene film of reinforcing layer combines, makes cable anti -impact performance promotion 40%, can bear 1000g instantaneous acceleration impact, solves the contradiction of rigid and easy to fold, soft and insufficient strength, the distributed optical fiber of intelligent detection layer and composite shielding layer can real -time monitoring temperature, strain and electromagnetic interference, realizes millimeter level fault location, the hollow glass bead repairing agent of repair layer releases and solidifies automatically when damage, completes micro -damage repair within 30 minutes, and the wear resistance restores above 80%, and the biological adhesion inhibition rate of cooperation biological protection layer 90%, makes maintenance cycle to extend 3 times above, compared with the passive maintenance mode of traditional cable, the fault risk of warship electrical system is reduced greatly, provides long -term safety guarantee for high -end warship equipment.

The invention discloses a method for improving the performance of a seaweed-based straw and a prepared seaweed-based straw additionally provided with a zein coating, and belongs to the technical field of biological coatings. The method comprises the following steps: soaking a seaweed-based straw in a zein solution for reaction, taking out the straw after the reaction is finished, and cleaning and drying the straw to obtain the seaweed-based straw with improved performance and additionally provided with the zein coating. According to the method, an anti-solvent and an electrostatic assembly method are combined for use, and zein is subjected to protonation reaction, carries positive charges and is subjected to electrostatic assembly with charged alginate on the surface of the straw by adjusting the pH value, so that stable interface bonding is realized, and the zein coating is additionally arranged on the surface of the straw. Due to the hydrophobicity of the prolamin, the straw additionally provided with the prolamin coating has excellent water resistance. In addition, the mechanical property of the seaweed-based suction pipe additionally provided with the coating is greatly improved.

An implant to retain facial or dental prostheses includes a bone-engaging portion, a transmucosal portion, and an abutment portion. The bone-engaging portion of the implant includes a longitudinally extending distal portion formed of a conformal microscale cell structure and, optionally, a non-biological coating. The transmucosal portion includes a plurality of micro holes. The abutment portion of the implant may be polished to a mirrored or super-mirrored finish.