The invention discloses a plasma cladding in-situ synthesized TiB2-TiC-TiN reinforced high-entropy alloy coating material and a preparation method thereof. The coating material comprises the following components according to atomic percentage: 17-19 percent of Co, 17-19 percent of Cr, 17-19 percent of Fe, 17-19 percent of Ni, 17-19 percent of Mn, 3-10 percent of Ti, 0.5-2 percent of B4C and 1.5-3 percent of BN. The preparation method comprises the steps as follows: (a), pre-treating a substrate; (b), preparing high-entropy alloy coating raw materials; (c), mixing powder; (d), preparing the high-entropy alloy by adopting plasma cladding equipment. The organization structure of the high-entropy alloy coating comprises an FCC phase, a BCC phase and a TiB2-TiC-TiN ternary ceramic phase, and favorable metallurgy bonding between a coating and the substrate is realized; the average Vickers hardness reaches 1,104 Hv.According to the invention, on the basis of the conventional high-entropy alloy coating,a TiB2-TiC-TiN reinforced phase is synthesized in-situ,the strength, hardness and the toughness of the coating are further improved, the match between the hardness and the toughness is achieved, and the potentiality of the high-entropy alloy coating is brought into play to the greatest extent. Moreover, the preparation method is reasonable in working procedures, simple and convenient to implement, is used for preparing durable antisepsis or abrasion proof coatings, and can remarkably prolong the service life of machinery parts.