The invention discloses a high-strength molybdenum nickel boron ternary boride material and a preparation method thereof. The high-strength molybdenum nickel boron ternary boride material comprises the following elements by content percent: 3% to 6% of boron, 35% to 55% of molybdenum, 1% to 8% of chromium, 0.2% to 0.8% of carbon, 0.5% to 4% of vanadium, 1% to 4% of niobium, 0.5% to 5% of tungsten, 0.1% to 1% of cerium and 1% to 3% of manganese, and the balance being nickel. According to the preparation method provided by the invention, the manufacturing technology is simple, atomization powder forming replaces mechanical ball milling powder forming, segregation is reduced during follow-up forming, toughness of the material is improved, and a high-strength Mo2NiB2-based metal ceramic material with a dense structure is obtained through HIP hot isostatic pressure sintering. The high-strength molybdenum nickel boron ternary boride material provided by the invention is scientific and reasonable in formula design, has high melting point, high hardness and high abrasion resistance and corrosion resistance, can be utilized as a high-temperature resistant material, corrosion-resistant material, abrasion-resistant material and superhard material, and is good in comprehensive performance.