22328 results about "Polyol" patented technology

Fast curing surgical adhesives and sealants contain an NCO-terminated hydrophilic urethane prepolymer derived from an aromatic diisocyanate and a polyol. Substantially all the aromatic diisocyanate used to prepare the NCO-terminated hydrophilic urethane prepolymer is in the para form. Optionally, the aromatic diisocyanate is substituted with at least one electron withdrawing group, such as, for example, a fluorine group.

The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a multifunctional amine or multifunctional polyol core, with isocyanate and/or polyalkylene oxide arms, which may optionally be capped with electrophilic or nucleophilic groups. These biocompatible components may, in embodiments, be combined with optional cross linkers to form adhesive and/or sealant compositions.

Processes and reactor systems are provided for the conversion of oxygenated hydrocarbons to hydrocarbons, ketones and alcohols useful as liquid fuels, such as gasoline, jet fuel or diesel fuel, and industrial chemicals. The process involves the conversion of mono-oxygenated hydrocarbons, such as alcohols, ketones, aldehydes, furans, carboxylic acids, diols, triols, and/or other polyols, to C₄₊ hydrocarbons, alcohols and/or ketones, by condensation. The oxygenated hydrocarbons may originate from any source, but are preferably derived from biomass.

The invention provides a liquid pharmaceutical formulation which does not include NaCl and comprises more than 20 mg of a polyol and at least about 100 mg/mL of a human anti-TNF-alpha antibody, or antigen-binding portion thereof. The invention provides a high concentration antibody formulation having long-term stability and advantageous characteristics for subcutaneous administration.

It has been desired to develop a highly preservative and antibacterial cosmetic composition that can easily be applied to both emulsion and non-emulsion type cosmetics. It has also been desired to develop a method of improving a preservative and/or antibacterial effect(s) of a cosmetic composition comprising polyorganosiloxane-containing epsilon-polylysine and thereby reducing the amount of antibacterial preservative agent to be used. There is provided a cosmetic composition comprising one or a combination of two or more of polyorganosiloxane-containing epsilon-polylysine compounds obtained by reacting epsilon-polylysine with polyorganosiloxane or a physiologically acceptable salt thereof, and polyhydric alcohol.

A polycarboxy binder composition that contains a dextrin as a co-binder is provided. The dextrin co-binder may be a dextrin, a modified dextrin, a maltodextrin, or combinations thereof. The dextrin may be chemically modified. A pre-binder composition is formed that contains a polycarboxy polymer, a crosslinking agent, and optionally a catalyst. The polycarboxy polymer may be a homopolymer or copolymer prepared from unsaturated carboxylic acids and may be modified to contain one or more vinyl compounds. The crosslinking agent may be a polyol that contains at least two hydroxyl groups. The pre-binder composition may be formed by admixing the polycarboxy polymer, the crosslinking agent, and optionally, the catalyst, in a mixing device. Dextrin may be added to the pre-binder composition in an amount of from 10-75% of the total binder composition. The dextrin binder composition may have a ratio of from approximately 90:10 to 25:75 pre-binder:dextrin co-binder.

Disclosed are aromatic polyester polyols, polyol based resin blends, and rigid closed-cell polyisocyanate-based foams made using the polyol based resin blends. The resin blends generally comprise:(a) an aromatic polyester polyol reaction product formed by inter-esterification of a phthalic acid based material; a hydroxylated material having a functionality of at least 2; and a hydrophobic material; and(b) a C4-C7 hydrocarbon blowing agent. Also disclosed is a method for preparing rigid closed-cell polyisocyanate-based foams comprising reacting a polyisocyanate and a polyol based resin blend.

A fully curable jettable composition having a viscosity less than 30 cps at a temperature within the range of 15-180° C., more preferably at a temperature of 15-100° C., e.g. 60-80° C. the composition comprising: (A) at least one low viscosity reactive resin selected from the group consisting of compounds containing an oxetane ring, cycloaliphatic epoxy resins, tetrahydrofurans, hexahydropyrans and mono-functional (meth)acrylates, said resin having a molecular weight of not greater than 300 Daltons, e.g. 250 Daltons or less, and a viscosity at a temperature in the said range of less than 30 cps, e.g. 5 to 15 cps; (B) at least one higher viscosity resin selected from the group consisting of epoxy resins, compounds containing an oxetane ring and acrylates, which resin acts to thicken the low viscosity resin and strengthen a jetted deposit of the composition, the higher viscosity resin having: a viscosity greater than twice that of the low viscosity resin at the said temperature in the range stated above, and a functionality of greater than or equal to 2; (C) at least one curable toughener, preferably having a functionality of at least 2, such as hydroxy, epoxy, acrylic or other reactive functionalised polymer/oligomer (e.g. derived by functionalising poly(tetrahydrofuran), polycaprolactone, polycarbonate diol, or a dendrimeric polyol; (D) at least one initiator for the polymerisation of the resins, and (E) at least one stabiliser for delaying the curing of the resins of the composition; wherein the low viscosity resin is slower to react than the higher viscosity resin and acts to solvate the higher viscosity resin prior to curing and at least partly during curing and wherein at least 30% of the components A and B are cationically curable resins. The composition can be jetted from piezo electric printing heads under the control of a computer program to form a multi-layered article, e.g. a three dimensional article, in which the adjacent droplets merge and are cured homogeneously together.

Processes and reactor systems are provided for the conversion of oxygenated hydrocarbons to paraffins useful as liquid fuels. The process involves the conversion of water soluble oxygenated hydrocarbons to oxygenates, such as alcohols, furans, ketones, aldehydes, carboxylic acids, diols, triols, and/or other polyols, followed by the subsequent conversion of the oxygenates to paraffins by dehydration and alkylation. The oxygenated hydrocarbons may originate from any source, but are preferably derived from biomass.

Recombinant Factor VIII can be produced in relatively large quantities on a continuous basis from mammalian cells in the absence of any animal-derived proteins such as albumin by culturing the cells in a protein free medium supplemented with polyol copolymers, preferably in the presence of trace metals such as copper. In very preferred embodiments, the medium includes a polyglycol known as Pluronic F-68, copper sulfate, ferrous sulfate/EDTA complex, and salts of trace metals such as manganese, molybdenum, silicon, lithium and chromium. With an alternative medium which included trace copper ions alone (without polyol copolymers) we were also able to enhance the productivity of Factor VIII in recombinant cells such as BHK cells that are genetically engineered to express Factor VIII.

Methods for preparing polyurethane flexible foam are described, wherein an organic polyisocyanate is reacted with an active hydrogen-containing component such as an organic polyol, in the presence of a urethane catalyst, a blowing agent, optionally a cell opener, and a siloxane-based surfactant composition as a stabilizer for the foam. The siloxane-based surfactant composition comprises a silanol-functionalized organosiloxane having general formula (I),

wherein:

the R groups are independently a C₁-C₃ alkyl, phenyl, or —OSi(R)₃; provided that at least one R group is a hydroxyl (—OH) bonded directly to any silicon atom and X is an integer from 0-200.

The invention provides multi-arm block copolymers useful as drug delivery vehicles comprising a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, methods of making such copolymers and pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.

The present invention provides polyurethane foams and elastomers made with an alkoxylated vegetable oil hydroxylate replacing at least a portion of the typically used petroleum-based polyol(s). Also provided are processes for making the inventive foams and elastomers and for making alkoxylated vegetable oil hydroxylates. The alkoxylated vegetable oil hydroxylates are environ mentally-friendly, bio-based polyols which advantageously also offer the potential of improved hydrophobicity in polyurethane foams and elastomers. The inventive polyurethane foams and elastomers may find use in a wide variety of products such as automobile interior parts, polyurethane structural foams, floor coatings and athletic running tracks.

A process for modifying an unsaturated polyol fatty acid ester stock, such as an unsaturated triacylglycerol oil, to enhance its reactivity provided. The method includes reacting the unsaturated polyol fatty acid ester stock with an oxygenating agent, such as an oxygen-containing gas. Tempering oils containing reactive polyol fatty acid esters and methods for their production and use are also provided.

Integrated processes of preparing industrial chemicals starting from seed oil feedstock compositions containing one or more unsaturated fatty acids or unsaturated fatty acid esters, which are essentially free of metathesis catalyst poisons, particularly hydroperoxides; metathesis of the feedstock composition with a lower olefin, such as ethylene, to form a reduced chain olefin, preferably, a reduced chain α-olefin, and a reduced chain unsaturated acid or ester, preferably, a reduced chain α,Ω-unsaturated acid or ester. The reduced chain unsaturated acid or ester may be (trans)esterified to form a polyester polyolefin, which may be epoxidized to form a polyester polyepoxide. The reduced chain unsaturated acid or ester may be hydroformylated with reduction to produce an α,Ω-hydroxy acid or α,Ω-hydroxy ester, which may be (trans)esterified with a polyol to form an α,Ωpolyester polyol. Alternatively, the reduced chain unsaturated acid or ester may be hydroformylated with reductive amination to produce an α,Ω-amino acid or α,Ω-amino ester, which may be (trans)esterified to form an α,Ωpolyester polyamine.

Well treatment is disclosed that includes injecting a well treatment fluid with insoluble polyol polymer such as polyvinyl alcohol (PVOH) dispersed therein, depositing the insoluble polymer in the wellbore or an adjacent formation, and thereafter dissolving the polymer by reducing salinity and/or increasing temperature conditions in the environment of the polymer deposit. The method is disclosed for filter cake formation, fluid loss control, drilling, hydraulic fracturing and fiber assisted transport, where removal of the polyol at the end of treatment or after treatment is desired. The method is also disclosed for providing dissolved polyol as a delayed breaker in crosslinked polymer viscosified systems and viscoelastic surfactant systems. Also disclosed are well treatment fluids containing insoluble amorphous or at least partially crystalline polyol, and a PVOH fiber composition wherein the fibers are stabilized from dissolution by salinity.

The present invention provides an isocyanate-reactive component containing at least 10 wt. %, based on the weight of the isocyanate-reactive component, of a vegetable oil-based polyol, a nonionic emulsifier containing one of an aliphatic alcohol ethoxylate and an aliphatic phenol ethoxylate having a polymerized ethylene oxide content of at least 25 moles per equivalent of alcohol or phenol and a HLB value greater than 17, one or more non-vegetable oil-based polyols, one or more silicone surfactants, and optionally, water or other blowing agents, catalysts, pigments and fillers, wherein the isocyanate-reactive component is storage stable at temperatures of from −10° C. to 60° C. for at least three days. The inventive isocyanate-reactive component can be shipped and stored at normal shipping and storage temperatures and still produce acceptable foam on a daily basis whilst helping to satisfy polyurethane foam and elastomer producers' “green” requirements.

There is provided a process for the preparation of an oil in water (O/W) microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, the method including the steps of a) Admixing a first part including at least one of the group consisting of animal, mineral or vegetable oils, silanes, siloxanes, esters, fatty acids, fats, halogen compounds or alkoxylated alcohols; and one or more lipophilic surfactants, and a second part including water and at least one hydrophilic surfactant to achieve homogeneity, b) heating the mix of step a) to a phase assembly temperature in the range of 40-99° C., preferably 45-95° C., more preferably 65-85° C. with continuous mixing to obtain a microemulsion or sub-micron emulsion, c) allowing said microemulsion or sub-micron emulsion to cool, and d) adding a third part to said microemulsion or sub-micron emulsion at a temperature between 2° C. and said phase assembly temperature, said third part if necessary being premixed and heated until the components are dissolved and including at least one component selected from the group consisting of non-surfactant amphiphilic type compound, surfactant and water with the proviso that when the third part includes water it also includes a non-surfactant amphiphilic type compound and/or surfactant. The phase assembly temperature can be determined visually by the achievement of translucence in the composition or by measures such as conductivity which peaks and then is maintained at a plateau whilst phase assembly occurs. It has been found that whilst if a non-surfactant amphiphilic type compound such as the polyol is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.

Disclosed is a polyol-in-silicone emulsion comprising: (a) a continuous silicone phase; (b) a discontinuous polyol phase; (c) a branched polyether-polydiorganosiloxane emulsifier; (d) an alkyl dimethicone copolymer emulsifier; and (e) a thickener for stabilizing the composition.

The present invention is a cosmetic or dermatological preparation for use with a dispenser that includes an auxiliary to keep the dispenser operating smoothly. The auxiliary is selected from the group consisting of (i) polyols having 2 to 6 carbon atoms and 2 to 6 hydroxyl or alkoxy groups and (ii) surfactants that reduce the surface tension of the preparation to less than 30 mN/m. The preparation is particularly suitable with a dispenser comprising a container and an inner container wall for housing a cosmetic or dermatological preparation; a follow-up plunger on a base side of the dispenser, which is capable of being slidably displaced on the inner container wall under the pressure of the ambient atmosphere; a head section on a top end of the dispenser that can be slidably displaced in relation to the container and that comprises a dispensing channel, the dispensing channel capable of being connected in a communicating manner to the container; a manually actuable delivery device comprising a variable-volume delivery chamber, a delivery element that can be displaced longitudinally in relation to the container and the head section, comprising a delivery plunger that can be slidably displaced within the delivery chamber and a delivery stem connected to the delivery plunger, and a delivery channel circumferentially enclosed by the delivery stem and comprising a delivery-channel inlet opening communicating with the delivery chamber and a delivery-channel outlet opening. The delivery channel outlet opening is capable of being moved into an open position relative to the dispensing channel by displacing the delivery element.

This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.

The invention relates to regenerative, supported amine sorbents that includes an amine or an amine/polyol composition deposited on a nano-structured support such as nanosilica. The sorbent provides structural integrity, as well as high selectivity and increased capacity for efficiently capturing carbon dioxide from gas mixtures, including the air. The sorbent is regenerative, and can be used through multiple operations of absorption-desorption cycles.

Specific core-shell binders and additives for use in ink-jet printing ink compositions are provided. One class of specific core/shell binders has the general formula [AmBnC'p]x, where A and B are hydrophobic components in which A exhibits a glass transition temperature Tg between about -150° and +25° C. and B exhibits a glass transition temperature greater than 25° C., C' is a component that forms a hydrophilic or water-soluble component in the polymer chain, and has an ionic or non-ionic structure, m<30 wt %, n>40 wt %, and p<30 wt %, with the total of m+n+p=100 wt %, and x=1 to 100,000. The molecular weight (weight average) of the polymer is between about 1,000 and 2,000,000. The polymers useful in the practice of the invention are prepared by emulsifying the monomers and then conducting a free-radical polymerization in water. The foregoing binder polymer is used in conjunction with additives comprising either (a) amine alcohols having the general formulawhere R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, and phenoxy, R is alkyl, X is selected from the group consisting of hydrogen, alkyl, aryl, -OH, -COOH, -CHO, and substituted groups or (b) organic acids (water-soluble or water-dispersive), including polymeric acids. Other additives include amines, polyalcohols, polyamines, and polyesters. In the ink compositions of the present invention, the ratio of binder (1) to colorant (pigment) is greater than 1 to 10. The concentration of the additive is within the range of 0.005 to 50 wt %. The general ink formulation comprises: 5 to 50 wt % water-miscible solvent; 0.5 to 10 wt % colorant; 0.005 to 50 wt % additive; and water.