110 results about "Oxetane" patented technology

The invention provides a halohydrin dehalogenase mutant and an application of the halohydrin dehalogenase mutant in synthesis of a chiral gamma-amino alcohol compound. Halogenated alcohol dehalogenase mutants enabling 2-substituted oxetane to be subjected to ring opening are obtained through the technologies of gene mining, directed evolution and the like, and the enzymes can directly perform ring opening on a substrate 2-aryl oxetane under the action of a nucleophilic reagent to generate a series of chiral gamma-amino alcohol compounds which are important precursors for synthesizing drugs. Therefore, the halohydrin dehalogenase mutants have important application value in the industry.

The present application relates to a kind of bismaleimide resin compositions and the semi-cured sheet and laminated plate prepared therefrom, comprising components: bismaleimide compound, allyl phenol compound and oxetane compound, the equivalent ratio range of double bond in the bismaleimide compound and double bond in the allyl phenol compound is 3~0.3, the oxetane compound accounts for 0.5~5% of the overall resin, the preparation process of semi-cured sheet and laminated plate includes the following preparation steps: step S1, the glue liquid prepared by bismaleimide resin composition is infiltrated into glass fiber cloth, and then baked and dried to obtain semi-cured sheet;Step S2, the surface of semi-cured sheet is covered with metal foil, and high-temperature pressing is formed, the advantage of the present application is that the glue liquid of resin composition, semi-cured sheet has good storage property, and the laminated plate prepared therefrom has excellent heat resistance, copper foil bonding force and moisture resistance.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The present invention relates to oxetane-based compounds, a method of manufacturing oxetane-based compounds, and to applications of the same.

A resin composition includes a coloring material, a resin, and a solvent. The resin includes a graft polymer which has a main chain including a molecular chain having a structure derived from a compound having an ethylenically unsaturated bond-containing group and a graft chain, and the graft chain includes a repeating unit p1 having an oxetane group. The resin composition may be employed in a film formed of the resin composition; an optical filter; a solid-state imaging element; and an image display device.

The invention provides a modified polyamide resin and a preparation method thereof, the modified polyamide resin comprises a structural unit derived from binary acid and diamine, and an end-capping structure derived from an oxetane compound of formula (I): (I) wherein R1 is C1-C6 alkyl, R2 is C1-C12 hydroxyalkyl or C2-C6 alkyl interrupted by an ether bond; wherein the molar ratio of the diamine to the binary acid is 1: (1-1.01); the mass of the oxetane compound is 1-3% of the mass of the modified polyamide resin; the number-average molecular weight of the modified polyamide resin is 25000 to 35000.

The utility model discloses a wear-resistant automobile cover which comprises an automobile cover body, the automobile cover body comprises a self-repairing layer, an ultraviolet-proof layer, a waterproof layer, a heat dissipation layer and a bottom cover, and the self-repairing layer, the ultraviolet-proof layer, the waterproof layer, the heat dissipation layer and the bottom cover are sequentially arranged from top to bottom. The self-repairing layer is a polyurethane coating containing chitosan and an oxetane structure, the bottom cover is made of polyester fibers, and by arranging the self-repairing layer, when the surface of the coating is scratched, the annular structure of oxetane in the self-repairing layer is broken and can generate chemical reaction after being exposed, and when ultraviolet light irradiates, the surface of the coating is not damaged, so that the surface of the coating is not damaged. The exposed tail ends of the chitosan and the oxetane in the coating attract each other and are combined together to repair the annular structure, so that the self-repair of the damaged part of the coating is realized, and the wear resistance and the practicability of the automobile cover are improved.

This invention discloses a microRNA-responsive 1,2-dioxane-based chemiluminescent compound, its dual-probe system, kit, synthesis method, and applications. The compound's core is an o-acrylate-substituted phenoxyadamantane-1,2-dioxane, with the phenolic hydroxyl group protected by an azide benzyl group. The two-component probe system constructed based on this compound comprises an azide-modified first probe and a phosphine-modified second probe, each complementary to different segments of the target microRNA. Hybridization brings the two probes closer, triggering a Staudinger reaction to remove the protecting group and activate the chemiluminescent signal. This probe system requires no enzyme amplification or nucleic acid extraction, achieves a detection limit of 1.37 fM, and a signal-to-noise ratio as high as 157-fold. It can be successfully used for real-time imaging of endogenous microRNA-21 in live cells, showing broad application prospects in early tumor screening, auxiliary diagnosis, and prognostic assessment.

Provided are a curable composition, a curable ink composition, and a curable ink composition for inkjet, each of which has low viscosity, low volatility, and curability. And methods of using these compositions are provided. The curable composition contains an epoxy / oxetane compound represented by chemical formula (I). In the formula, n is the same or different and represents an integer of 2-5.

A novel crystalline form of a GLP-1 receptor agonist, its preparation method, its pharmaceutical composition, and its use are provided. The GLP-1 receptor agonist is designated Compound I, i.e., (S)-2-((4-(6-((2-fluoro-4-(oxetan-3-yl)benzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylic acid.

The present invention relates to compounds of formula (I) as activators of glucagon-like peptide 1 (GLP1) receptor for the treatment of obesity, type 2 diabetes, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, one or more diabetic complications, diabetic nephropathy, dyslipidemia, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), hypertension, atherosclerosis, peripheral arterial disease, stroke, cardiomyopathy, atrial fibrillation, heart failure, coronary heart disease, and neuropathy.Preferred compounds are, for example, 2-((4-((S)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-imidazole derivatives and similar compounds, such as C-1, C-2, C-3, C-4 and other compounds. [Formula 1] TIFF2024514826000258.tif26170 [chemical 2] TIFF2024514826000259.tif58170

The invention provides a laser debonding adhesive and a method for temporarily bonding a substrate. The laser debonding adhesive includes: a polyimide; the cross-linking agent is selected from at least one of a group consisting of ethylene oxide resin and oxetane resin; a solvent; the cross-linking agent accounts for more than or equal to 20wt% of the total solid content of the laser debonding adhesive. The method for temporarily adhering the substrate comprises the following steps of: coating the laser debonding adhesive on the surface of the substrate; a step of baking the substrate and the laser debonding adhesive; adhering an object to be adhered to the laser debonding adhesive on the substrate; and irradiating the laser debonding adhesive with laser to separate the substrate from the laser debonding adhesive.

A method for continuously producing oxetane methyl methacrylate by transesterification, which utilizes dibutyl tin oxide, methyl methacrylate and 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl radical to prepare a catalyst; methyl methacrylate is subjected to transesterification with 3-ethyl-3-oxetanemethanol, a polymerization inhibitor tetramethylpiperidine nitroxide phosphite triester and the catalyst to obtain a transesterification reaction liquid; the transesterification reaction liquid is subjected to vacuum rectification in a transesterification reactor, after recovering methyl methacrylate and 3-ethyl-3-oxetanemethanol, vacuum rectification is continued to obtain oxetane methyl methacrylate. The advantage is that the process is simple and reasonable, not only high in conversion rate and selectivity, but also high in purity, low in color and acid value of the obtained product, friendly to the environment and fully capable of meeting the application requirements in high-end fields.

The present invention addresses the problem of providing a composition capable of transferring fine and densely mounted semiconductor chips with high positional accuracy. The solution to the aforementioned problem is a composition containing a compound (a) and a compound (b), wherein the compound (a) accounts for more than 50 mass% and no more than 95 mass% relative to 100 mass % of the solid content of the composition.　The compound (a) has two or more groups bonded by reacting with a crosslinking group of the compound (b) per molecule, has maximum absorption in any wavelength within the range of 240 to 400 nm, and has a gram absorption coefficient of 40 to 4000 L / (g·cm) at the maximum absorption wavelength. The compound (b) does not correspond to the compound (a) and has two or more crosslinking groups per molecule, the crosslinking groups being groups selected from the group consisting of epoxy groups, oxetanyl groups, alkoxymethyl groups, methylol groups, and isocyanate groups.

The invention discloses a microRNA (Ribonucleic Acid) response type 1, 2-dioxetane chemiluminescent compound as well as a double-probe system, a kit, a synthesis method and application thereof. The parent nucleus of the compound is o-acrylate substituted phenoxy adamantane-1, 2-dioxetane, and a phenolic hydroxyl group is protected by an azido benzyl group. A two-component probe system constructed based on the compound comprises a first azide-modified probe and a second phosphino-modified probe, the first azide-modified probe and the second phosphino-modified probe are respectively complementary with different sections of target microRNA, the two probes are pulled close through hybridization, a schudinger reaction is triggered to remove a protecting group, and a chemiluminescence signal is activated. The probe system does not need enzyme amplification and nucleic acid extraction, the detection limit reaches 1.37 fM, the signal-to-noise ratio reaches up to 157 times, and the probe system can be successfully used for real-time imaging of living cell endogenous microRNA-21 and has wide application prospects in the fields of early tumor screening, auxiliary diagnosis and prognosis evaluation.

This invention relates to a method for preparing a bimetallic cyanide (DMC) catalyst, comprising a reaction of an aqueous solution of a cyanide-free metal salt, an aqueous solution of a basic metal cyanide salt, an organic complexing ligand, and optionally a component forming a complex, wherein the metal cyanide salt is one or more compounds selected from potassium hexacyanocobalt(III), potassium hexacyanoferrate(II), potassium hexacyanoferrate(III), calcium hexacyanocobalt(III), and lithium hexacyanocobalt(III), wherein the organic complexing ligand is one or more compounds selected from dimethoxyethane, tert-butanol, 2-methyl-3-buten-2-ol, 2-methyl-3-butyn-2-ol, ethylene glycol mono-tert-butyl ether, and 3-methyl-3-oxetane-methanol, and wherein the basic metal cyanide salt used has an alkalinity between 0.700 wt% and 3.000 wt% sodium hydroxide (NaOH) based on the total weight of the basic metal cyanide salt used, determined by titration as disclosed in the experimental section. Another subject of the invention includes a bimetallic cyanide catalyst (DMC) obtainable by the method according to the invention, and the use of said DMC catalyst in the preparation of polyoxyethylene polyols.

The present disclosure provides a liquid resin composition with which it is possible to achieve high photo-curability and a reduction in the linear expansion coefficient of a cured product. The liquid resin composition contains a cationically polymerizable component (A), a photocationic polymerization initiator (B), and an inorganic filler (C). The cationically polymerizable component (A) includes a polyfunctional cationically polymerizable compound (A1) and a monofunctional cationically polymerizable compound (A2). The polyfunctional cationically polymerizable compound (A1) comprises at least one selected from the group consisting of a polyfunctional oxetane compound (A11) and a polyfunctional alicyclic epoxy compound (A12).

A display device includes: a display panel configured to fold along a folding axis; and a protective member disposed on the display panel, wherein the protective member includes: a protective base layer; a hard coating layer including a polymer derived from a coating composition, wherein the hard coating layer is disposed on the protective base layer; and an antireflection layer including a high refractive index layer and a low refractive index layer disposed on the high refractive index layer, wherein the antireflection layer is disposed on the hard coating layer, wherein the coating composition includes a silsesquioxane-based resin, an oxetane-based resin, a photopolymerization initiator, and silica nanoparticles, and wherein a first weight of the silica nanoparticles is about 3 wt % to about 5 wt % based on a total weight of the coating composition.

The hard coating composition includes a solvent and a hard coating solid matter. The hard coating solid substance comprises a silsesquioxane compound, a free radical polymerization initiator and a cationic polymerization initiator, the silsesquioxane compound comprises a free radical polymerizable functional group and a cationic polymerizable functional group, the free radical polymerizable functional group comprises a (meth) acrylate group, and the cationic polymerizable functional group comprises a (meth) acrylate group. The cationically polymerizable functional group includes an oxetane group. A method of manufacturing a window includes applying a hard coating composition on a base layer to form a preliminary hard coating; drying the preliminary hard coating to remove the solvent; and curing the dried preliminary hard coating layer to form the hard coating layer. The electronic device comprises a window manufactured by the method and a power module for supplying power.

The invention provides a delayed UV curing packaging adhesive for an OLED (Organic Light Emitting Diode) display panel, the OLED display panel and a manufacturing method of the OLED display panel. The delayed UV curing packaging adhesive for the OLED display panel comprises the following components in parts by weight: 40-70 parts of glycidyl ether epoxy resin; 1 to 10 parts of oxetane resin; 30 to 50 parts of a nano-scale filling material; 0.1 to 1 part of a defoaming agent; 0.1 to 2 parts of a photoinitiator; 0.1 to 2 parts of a dispersant; 0.1 to 5 parts of PS (polystyrene) microspheres; and 0.1-1 part of an organic delayed curing agent. The organic delayed curing agent is used for reducing the viscosity of the delayed UV curing packaging adhesive for the OLED display panel after UV pre-curing, so that the viscosity of the delayed UV curing packaging adhesive for the OLED display panel after UV pre-curing operation in the pressing and fixing operation process is 400 P.S to 1600 P.S. The delayed UV curing packaging adhesive for the OLED display panel not only can prevent external water, oxygen or pollutants from entering the box dam structure, but also can prevent the fill adhesive from overflowing from the box dam structure.

The invention provides a 1, 2-dioxetane derivative as well as a preparation method and application thereof, and belongs to the technical field of chemiluminescent substrates. The 1, 2-dioxetane derivative provided by the invention has high luminous efficiency and good stability. The result of the embodiment shows that the time required by the 1, 2-dioxetane derivative provided by the invention to reach the maximum luminescence peak value at 25 DEG C is only 5-30 minutes, and the continuous luminescence time can reach 70 minutes.

According to the preparation method, an oxetane derivative with an amino group and 2, 4-dichloro-6-methylquinazoline are subjected to a substitution reaction, the amino oxetane derivative is directly introduced to the 2, 4-dichloro-6-methylquinazoline, and then the reaction is carried out, so that the reaction yield is improved, and the reaction time is shortened. The method can effectively avoid the process of preparing primary amine from halide with more byproducts in the existing method, and simplifies the purification and preparation process of intermediate products. The inventor designs the new intermediate of the Zirisovir, so that the aims that the reaction process of preparing the Zirisovir from the new intermediate is easier to control, few by-products are produced, the product is simple to purify and refine, and the yield is higher are fulfilled, and the method is suitable for industrial large-scale production.

The application discloses a preparation method of 3-iodooxetane. The 3-iodooxetane is prepared by adding a copper ion catalyst to make halogen exchange reaction of 3-substituted oxetane, an iodination reagent and a solvent. In the application, the introduction of the catalyst greatly reduces the activation energy of the reaction, thereby improving the selectivity of the reaction and the yield of the reaction. The application has the advantages of low raw material cost, short reaction time, high product purity and yield and the like, is very friendly to the environment and meets the requirements of green chemical process.

The present invention relates to the compound of formula (I), wherein all the variables are as defined in the specification. The present invention also relates to a preparation method for the compound of formula (I), a photocurable composition containing the compound of formula (I), a photocurable material prepared from the photocurable composition, and the use of the compound of formula (I) in the field of photocurable materials. The present invention has the following beneficial effects: (1) the compound of formula (I) has relatively good photopolymerization activity, and can be rapidly cured under the action of ultraviolet light; and (2) by means of the addition of the compound of formula (I), the surface hydrophobicity, heat resistance and tensile properties of a cured film can be improved.

The invention provides conductive slurry, a conductive electrode, a crystalline silicon perovskite laminated cell and a preparation method. The conductive paste comprises the following components by mass: 89-96 wt% of conductive metal powder; 0.8 to 10 weight percent of epoxy resin; 0.2 to 6 wt% of an oxetane compound; 0.1-2 wt% of a hot acid type cationic curing agent; wherein the viscosity of the epoxy resin is 5 to 20000 cP. The thermosetting resin is used as a main organic component in the conductive paste, can quickly react under the catalysis of a curing agent in a short time at a low temperature, has good compatibility with silver powder, and can form uniform conductive paste after being mixed with the silver powder. The epoxy resin and the oxetane compound can be cured at a low temperature for a short time in the presence of the hot acid type cationic curing agent, and the conductive slurry can achieve enough low volume resistivity and contact resistivity, so that the requirement of the perovskite laminated cell on an electrode is met.

This invention belongs to the interdisciplinary field of polymer materials and supramolecular chemistry, specifically relating to a polyurethane slip-ring crosslinked network elastic material with a slip-ring effect. The invention uses a macrocyclic molecule with oxetane-functionalized side groups as the cyclic component of a rotaxane. Through host-guest inclusion interactions, it forms a rotaxane polymer with the linear backbone, followed by a ring-opening crosslinking reaction of the oxetane groups, constructing an interpenetrating network structure that combines a three-dimensional covalent network with a supramolecular slip-ring effect. Under mechanical stimulation, this material dissipates energy through the relative slippage of the ring molecules along the backbone, exhibiting high resilience and wide-temperature-range stability. It can be applied in fields such as flexible electronics, wearable devices, and high-performance damping materials.

The present invention addresses the problem of providing a composition having excellent adhesion to various plastic films and low viscosity. The present invention is a composition containing an alicyclic epoxy compound (A), a monofunctional epoxy compound (B), an oxetane compound (C), and a cationic polymerization initiator (D), the alicyclic epoxy compound (A) being contained in an amount of 50 parts by mass or more per 100 parts by mass of the total amount of the alicyclic epoxy compound (A), the monofunctional epoxy compound (B), and the oxetane compound (C). The alicyclic epoxy compound (A) is preferably a compound (A1) having two or more alicyclic epoxy groups.

This invention discloses a method for synthesizing 3-oxa[3.1.1]spiropropane, belonging to the fields of organic synthetic chemistry and medicinal chemistry. This method is the first to introduce oxygen atoms into the high-strength skeleton of [3.1.1]spiropropane, successfully synthesizing the 3-oxa[3.1.1]spiropropane molecule. The specific synthetic route is as follows: starting with 3,3-bis(bromomethyl)oxacyclobutane, the 3-oxabicyclo[3.1.1]heptane diol skeleton is constructed sequentially via nucleophilic substitution with diethyl malonate, reduction, and intramolecular cyclization. Then, oxidation and Barton decarboxylation iodination are performed to obtain the key intermediate 1,3-diiodo-3-oxabicyclo[3.1.1]heptane, which is finally reacted with an organolithium reagent to obtain the target product. This invention fills a technological gap in the synthesis of heteroatom-substituted spiroalkyl, providing a key precursor for the subsequent development of its free radical bifunctionalization reaction and the construction of structurally diverse 3-oxabicyclic [3.1.1]heptane dominant skeletons. It has important application prospects in drug design, especially as a bio-electroisoster of meta-substituted aromatics.

The utility model relates to organic chemical synthesis and continuous production technical field discloses a kind of 3-methyl-3-carboxyl-1-oxetane continuous production device, including bottom plate, the upper surface of the bottom plate is fixedly connected with stirring drum, the upper surface of the support column is fixedly connected with motor, the output of the motor is fixedly provided with rotating plate, the outer wall of the rotating plate is slidably connected with sliding column, the outer wall of the sliding column is fixedly connected with sliding ball, the lower surface of the sliding column is fixedly connected with stirring rod, the inside of the stirring drum is provided with closed assembly, and the closed assembly is used to close stirring drum.In the utility model, through the cooperation between bottom plate, motor, sliding column, sliding ball, groove column and stirring rod, different liquid levels and areas can be stirred in real time, the effect of breaking the dead angle of fixed stirring is realized, the raw materials, catalysts and products are fully mixed in the device, and the stability of continuous production and product uniformity are ensured.