182 results about "Oxetane" patented technology

The invention provides a halohydrin dehalogenase mutant and an application of the halohydrin dehalogenase mutant in synthesis of a chiral gamma-amino alcohol compound. Halogenated alcohol dehalogenase mutants enabling 2-substituted oxetane to be subjected to ring opening are obtained through the technologies of gene mining, directed evolution and the like, and the enzymes can directly perform ring opening on a substrate 2-aryl oxetane under the action of a nucleophilic reagent to generate a series of chiral gamma-amino alcohol compounds which are important precursors for synthesizing drugs. Therefore, the halohydrin dehalogenase mutants have important application value in the industry.

The invention provides a preparation method of (S)-oxetane-2-methylamine. The preparation method of (S)-oxetane-2-methylamine comprises the following steps: (1) carrying out ring closing reaction on a compound A under an alkaline condition to obtain a compound B; (2) reacting the compound B with dibenzylamine to obtain a compound C; (3) reacting the compound C with a reducing agent to obtain a compound D; (4) reacting the compound D with paratoluensulfonyl chloride to obtain a compound E; (5) reacting the compound E with alkali to obtain a compound F; and (6) carrying out a reaction on the compound F and palladium on carbon to obtain the (S)-oxetane-2-methylamine. According to the preparation method provided by the invention, ring expansion reaction using trimethylsulfoxide iodide in the prior art is avoided, the problem that residual sulfur elements cause poisoning of a palladium-carbon catalyst is solved, meanwhile, sodium azide is also avoided, and the preparation method is safe and reliable in process, high in chiral purity and yield and suitable for industrial large-scale production.

The present application relates to a kind of bismaleimide resin compositions and the semi-cured sheet and laminated plate prepared therefrom, comprising components: bismaleimide compound, allyl phenol compound and oxetane compound, the equivalent ratio range of double bond in the bismaleimide compound and double bond in the allyl phenol compound is 3~0.3, the oxetane compound accounts for 0.5~5% of the overall resin, the preparation process of semi-cured sheet and laminated plate includes the following preparation steps: step S1, the glue liquid prepared by bismaleimide resin composition is infiltrated into glass fiber cloth, and then baked and dried to obtain semi-cured sheet;Step S2, the surface of semi-cured sheet is covered with metal foil, and high-temperature pressing is formed, the advantage of the present application is that the glue liquid of resin composition, semi-cured sheet has good storage property, and the laminated plate prepared therefrom has excellent heat resistance, copper foil bonding force and moisture resistance.

Disclosed herein are novel formulations of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including formulations including various solid forms thereof. Also disclosed are processes for preparing formulations of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

The present invention addresses the problem of providing: a resin composition that is capable of at least being photocured or being cured at low temperature (for example, 100°C or less) and that provides a cured product that exhibits excellent adhesive strength and high heat-resistance reliability; an adhesive agent or a sealing material that includes the same; a cured product thereof; and a semiconductor device and an electronic component that include the cured product.　Provided are: a resin composition containing (A) an epoxy compound, (B) an oxetane compound, and (C) an acid-generating agent that is a salt of an anion represented by formula (1) (In the formula, R1, R2, R3, and R4 independently represent an alkyl group having 1-18 carbon atoms or an aryl group having 6-14 carbon atoms, provided, however, that at least one of R1, R2, R3, and R4 represents an aryl group having 6-14 carbon atoms.) and of a counter cation, and also satisfying at least one of the following characteristics (a) and (b); an adhesive agent or a sealing material including the same; a cured product thereof; and a semiconductor device and an electronic component including the cured product. (a) (D) A filler is further included. (b) The content of (A) the epoxy compound is 100-1300 parts by weight with respect to 100 pats by weight of (B) the oxetane compound.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The present invention relates to oxetane-based compounds, a method of manufacturing oxetane-based compounds, and to applications of the same.

A resin composition includes a coloring material, a resin, and a solvent. The resin includes a graft polymer which has a main chain including a molecular chain having a structure derived from a compound having an ethylenically unsaturated bond-containing group and a graft chain, and the graft chain includes a repeating unit p1 having an oxetane group. The resin composition may be employed in a film formed of the resin composition; an optical filter; a solid-state imaging element; and an image display device.

Disclosed herein is a method of treating pemphigus in a human patient in need thereof, comprising administering to the human patient a dose of at least 400 mg of (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (PRN1008) once daily (QD) or twice daily (BID).

The present invention refers to a light emitting diode (LED) curable composition, wherein the composition comprises a cationic curable resin comprising a1) an epoxide, a2) an oxetane, a3) a cationic initiator, and a4) a photosensitizer, wherein the weight ratio between the epoxide a1) and the oxetane a2) is in the range of 1-5. The present invention also refers to the use of said LED curable composition for producing a coating that is cured with a LED light source at a wavelength in the range of 275-405 nm.

The application discloses a kind of for tape bottom layer on ultraviolet light solidification dip coating ink, the ultraviolet light solidification dip coating ink is composed of the following weight parts of component: photocuring oligomer: 30-50 parts, functional active monomer: 20-50 parts, photo initiator: 3-6 parts pigment: 5-35 parts, dispersing agent: 1-3 parts, surface auxiliary agent: 1-2 parts;The synthesis steps of the photocuring oligomer are: after epoxy E51 is mixed with octandioic acid, under the condition of nitrogen protection, temperature is controlled 115 DEG C, reaction 3-4h, when acid value is less than 10mgKOH / g, reduce reaction temperature to 85-95 DEG C, add polymerization inhibitor, slowly drop catalyst and glutaric acid-3-ethyl-3-oxetane monomethyl ester, drop adding time is controlled at 30-40min, and reaction 7-8h, when acid value is less than 10mgKOH / g, control reaction temperature to 65-75 DEG C, add isocyanatoethyl acrylate and reaction 5-6h, obtain photocuring oligomer with oxetane and acrylate structure simultaneously.The application has the characteristics of low viscosity, good leveling performance, has very good adhesion on steel tape, and solidification speed is relatively fast.

The invention provides a modified polyamide resin and a preparation method thereof, the modified polyamide resin comprises a structural unit derived from binary acid and diamine, and an end-capping structure derived from an oxetane compound of formula (I): (I) wherein R1 is C1-C6 alkyl, R2 is C1-C12 hydroxyalkyl or C2-C6 alkyl interrupted by an ether bond; wherein the molar ratio of the diamine to the binary acid is 1: (1-1.01); the mass of the oxetane compound is 1-3% of the mass of the modified polyamide resin; the number-average molecular weight of the modified polyamide resin is 25000 to 35000.

The utility model discloses a wear-resistant automobile cover which comprises an automobile cover body, the automobile cover body comprises a self-repairing layer, an ultraviolet-proof layer, a waterproof layer, a heat dissipation layer and a bottom cover, and the self-repairing layer, the ultraviolet-proof layer, the waterproof layer, the heat dissipation layer and the bottom cover are sequentially arranged from top to bottom. The self-repairing layer is a polyurethane coating containing chitosan and an oxetane structure, the bottom cover is made of polyester fibers, and by arranging the self-repairing layer, when the surface of the coating is scratched, the annular structure of oxetane in the self-repairing layer is broken and can generate chemical reaction after being exposed, and when ultraviolet light irradiates, the surface of the coating is not damaged, so that the surface of the coating is not damaged. The exposed tail ends of the chitosan and the oxetane in the coating attract each other and are combined together to repair the annular structure, so that the self-repair of the damaged part of the coating is realized, and the wear resistance and the practicability of the automobile cover are improved.

This invention discloses a microRNA-responsive 1,2-dioxane-based chemiluminescent compound, its dual-probe system, kit, synthesis method, and applications. The compound's core is an o-acrylate-substituted phenoxyadamantane-1,2-dioxane, with the phenolic hydroxyl group protected by an azide benzyl group. The two-component probe system constructed based on this compound comprises an azide-modified first probe and a phosphine-modified second probe, each complementary to different segments of the target microRNA. Hybridization brings the two probes closer, triggering a Staudinger reaction to remove the protecting group and activate the chemiluminescent signal. This probe system requires no enzyme amplification or nucleic acid extraction, achieves a detection limit of 1.37 fM, and a signal-to-noise ratio as high as 157-fold. It can be successfully used for real-time imaging of endogenous microRNA-21 in live cells, showing broad application prospects in early tumor screening, auxiliary diagnosis, and prognostic assessment.

The present invention relates to the technical field of carbon nanotube modification, specifically a flame-retardant carbon nanotube conductive material and a preparation process thereof. The method comprises the following steps: S1: reacting chlorinated carbon nanotubes with 4-aminobenzophenone and DOPO in sequence to obtain DOPO-carbon nanotubes; S2: reacting chain polyphosphazenes with (1-hydroxyallyl)trimethylsilane and oxetane-3-thiol in sequence to obtain oxacyclic-chain polyphosphazenes; and S3: mixing DOPO-carbon nanotubes, oxacyclic-chain polyphosphazenes, and pyrrole to prepare the flame-retardant carbon nanotube conductive material.

Provided are a curable composition, a curable ink composition, and a curable ink composition for inkjet, each of which has low viscosity, low volatility, and curability. And methods of using these compositions are provided. The curable composition contains an epoxy / oxetane compound represented by chemical formula (I). In the formula, n is the same or different and represents an integer of 2-5.

Modified release formulations, such as solid oral dosage forms comprising a core composition comprising Compound (I) and / or a pharmaceutically acceptable salt thereof; a sub-coating layer coating the core composition, said sub-coating layer comprising a polyvinyl alcohol and / or a hydroxypropyl methyl cellulose; and an enteric coating layer encapsulating the sub-coating layer and the core composition, said enteric coating layer comprising at least one polymer selected from an acrylic / methacrylic / ethacrylic acid homopolymer and copolymers thereof, a cellulose derivative, and a polyvinylpyrrolidone, and methods of administration of a Bruton's tyrosine kinase (BTK) inhibitor using said formulations.

A novel crystalline form of a GLP-1 receptor agonist, its preparation method, its pharmaceutical composition, and its use are provided. The GLP-1 receptor agonist is designated Compound I, i.e., (S)-2-((4-(6-((2-fluoro-4-(oxetan-3-yl)benzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylic acid.

The present invention relates to compounds of formula (I) as activators of glucagon-like peptide 1 (GLP1) receptor for the treatment of obesity, type 2 diabetes, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, one or more diabetic complications, diabetic nephropathy, dyslipidemia, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), hypertension, atherosclerosis, peripheral arterial disease, stroke, cardiomyopathy, atrial fibrillation, heart failure, coronary heart disease, and neuropathy.Preferred compounds are, for example, 2-((4-((S)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-imidazole derivatives and similar compounds, such as C-1, C-2, C-3, C-4 and other compounds. [Formula 1] TIFF2024514826000258.tif26170 [chemical 2] TIFF2024514826000259.tif58170

The invention provides a laser debonding adhesive and a method for temporarily bonding a substrate. The laser debonding adhesive includes: a polyimide; the cross-linking agent is selected from at least one of a group consisting of ethylene oxide resin and oxetane resin; a solvent; the cross-linking agent accounts for more than or equal to 20wt% of the total solid content of the laser debonding adhesive. The method for temporarily adhering the substrate comprises the following steps of: coating the laser debonding adhesive on the surface of the substrate; a step of baking the substrate and the laser debonding adhesive; adhering an object to be adhered to the laser debonding adhesive on the substrate; and irradiating the laser debonding adhesive with laser to separate the substrate from the laser debonding adhesive.

The present application provides an oxo-modified acrylate compound, a preparation method and applications thereof. The compound contains an oxetane functional group and two (meth)acrylic acid functional groups, and can be used as a monomer for simultaneous radical curing, cationic curing, and radical-cation hybrid system curing. The present application also relates to a method for preparing the oxo-modified acrylate compound and applications of a cured composition thereof.

A method for continuously producing oxetane methyl methacrylate by transesterification, which utilizes dibutyl tin oxide, methyl methacrylate and 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl radical to prepare a catalyst; methyl methacrylate is subjected to transesterification with 3-ethyl-3-oxetanemethanol, a polymerization inhibitor tetramethylpiperidine nitroxide phosphite triester and the catalyst to obtain a transesterification reaction liquid; the transesterification reaction liquid is subjected to vacuum rectification in a transesterification reactor, after recovering methyl methacrylate and 3-ethyl-3-oxetanemethanol, vacuum rectification is continued to obtain oxetane methyl methacrylate. The advantage is that the process is simple and reasonable, not only high in conversion rate and selectivity, but also high in purity, low in color and acid value of the obtained product, friendly to the environment and fully capable of meeting the application requirements in high-end fields.

The present invention addresses the problem of providing a composition capable of transferring fine and densely mounted semiconductor chips with high positional accuracy. The solution to the aforementioned problem is a composition containing a compound (a) and a compound (b), wherein the compound (a) accounts for more than 50 mass% and no more than 95 mass% relative to 100 mass % of the solid content of the composition.　The compound (a) has two or more groups bonded by reacting with a crosslinking group of the compound (b) per molecule, has maximum absorption in any wavelength within the range of 240 to 400 nm, and has a gram absorption coefficient of 40 to 4000 L / (g·cm) at the maximum absorption wavelength. The compound (b) does not correspond to the compound (a) and has two or more crosslinking groups per molecule, the crosslinking groups being groups selected from the group consisting of epoxy groups, oxetanyl groups, alkoxymethyl groups, methylol groups, and isocyanate groups.

The invention discloses a microRNA (Ribonucleic Acid) response type 1, 2-dioxetane chemiluminescent compound as well as a double-probe system, a kit, a synthesis method and application thereof. The parent nucleus of the compound is o-acrylate substituted phenoxy adamantane-1, 2-dioxetane, and a phenolic hydroxyl group is protected by an azido benzyl group. A two-component probe system constructed based on the compound comprises a first azide-modified probe and a second phosphino-modified probe, the first azide-modified probe and the second phosphino-modified probe are respectively complementary with different sections of target microRNA, the two probes are pulled close through hybridization, a schudinger reaction is triggered to remove a protecting group, and a chemiluminescence signal is activated. The probe system does not need enzyme amplification and nucleic acid extraction, the detection limit reaches 1.37 fM, the signal-to-noise ratio reaches up to 157 times, and the probe system can be successfully used for real-time imaging of living cell endogenous microRNA-21 and has wide application prospects in the fields of early tumor screening, auxiliary diagnosis and prognosis evaluation.

The present invention addresses the problem of providing a liquid crystal composition, a liquid crystal cured layer, an optical film, a polarizing plate, an image display device, and a copolymer, said liquid crystal composition containing a copolymer having excellent compatibility with a liquid crystal compound, and having excellent leveling properties and excellent adhesiveness. The liquid crystal composition according to the present invention contains a liquid crystal compound and a copolymer containing a repeating unit A and a repeating unit B. The repeating unit A is a repeating unit represented by formula (A1) or a repeating unit represented by formula (A2). The repeating unit B is a repeating unit having at least one group selected from the group consisting of a hydroxyl group, a boric acid group, a boric acid ester group, a boric acid amide group, an epoxy group, an oxetanyl group, a vinyl group, a styryl group, a (meth) acryloyl group, and a maleimide group.

This invention relates to a method for preparing a bimetallic cyanide (DMC) catalyst, comprising a reaction of an aqueous solution of a cyanide-free metal salt, an aqueous solution of a basic metal cyanide salt, an organic complexing ligand, and optionally a component forming a complex, wherein the metal cyanide salt is one or more compounds selected from potassium hexacyanocobalt(III), potassium hexacyanoferrate(II), potassium hexacyanoferrate(III), calcium hexacyanocobalt(III), and lithium hexacyanocobalt(III), wherein the organic complexing ligand is one or more compounds selected from dimethoxyethane, tert-butanol, 2-methyl-3-buten-2-ol, 2-methyl-3-butyn-2-ol, ethylene glycol mono-tert-butyl ether, and 3-methyl-3-oxetane-methanol, and wherein the basic metal cyanide salt used has an alkalinity between 0.700 wt% and 3.000 wt% sodium hydroxide (NaOH) based on the total weight of the basic metal cyanide salt used, determined by titration as disclosed in the experimental section. Another subject of the invention includes a bimetallic cyanide catalyst (DMC) obtainable by the method according to the invention, and the use of said DMC catalyst in the preparation of polyoxyethylene polyols.

The present disclosure provides a liquid resin composition with which it is possible to achieve high photo-curability and a reduction in the linear expansion coefficient of a cured product. The liquid resin composition contains a cationically polymerizable component (A), a photocationic polymerization initiator (B), and an inorganic filler (C). The cationically polymerizable component (A) includes a polyfunctional cationically polymerizable compound (A1) and a monofunctional cationically polymerizable compound (A2). The polyfunctional cationically polymerizable compound (A1) comprises at least one selected from the group consisting of a polyfunctional oxetane compound (A11) and a polyfunctional alicyclic epoxy compound (A12).

This invention discloses a catalyst for the oxidation of 3-oxetane to 3-oxetane, its preparation method, and its application. The method uses an Al₂O₃-supported metal composite oxide (CuO-Fe₂O₃-MnO₂ / Al₂O₃) as the catalyst, with CuO content ranging from 1% to 10% by mass; Fe₂O₃ content ranging from 0.5% to 2% by mass; and MnO₂ content ranging from 0.5% to 2% by mass. The application includes the following steps: 3-oxetane is oxidized with oxygen, air, or hydrogen peroxide in the presence of a solvent and the catalyst to obtain 3-oxetane. The method features mild reaction conditions, high product yield, is environmentally friendly, and the catalyst can be recycled and reused.