The invention relates to a method for preparing a water polyurethane adhesive applied to shoes, pertaining to the technical field of polymers. A proper amount of first polyatomic alcohol, second polyatomic alcohol, third polyatomic alcohol and fourth polyatomic alcohol are mixed to achieve polyurethane prepolymers; a proper amount of triethylamine is added for neutralization; the prepared polyurethane prepolymers is dispersed into deionized water and added with surface-active agent to achieve water polyurethane dispersoid; a proper amount of ethylene diamine is added into the water polyurethane dispersoid for chain expanding reaction to achieve water polyurethanes; the acetone is removed by vacuum pressure reduction, and finally mixed with antioxidant, ultraviolet absorbent, leveling agent, antifoaming agent, wetting agent, thickening agent and silane coupling agent to achieve the water polyurethane adhesive. The invention provides a simple process, needs a small dosage of organic solvent, the solid content is above 50 percent, the energy consumption of production is relatively low; besides, the adhesive has excellent bonding strength to various shoe materials such as PVC, polyurethane, leather, SBS, canvas, rubber and so on, and the heat-resistance effect is strong.