298 results about "Cysteamine" patented technology

The subject invention provides materials and methods for modulating a variety of biological factors to treat biological conditions associated with the factors. In one embodiment of the invention, a cysteamine compound is administered to a patient to treat hypercholesterolemia and / or complications associated with hypercholesterolemia. In another embodiment, a cysteamine compound is administered to a patient to prevent the onset of diabetes in an at-risk patient and / or treat or prevent the onset of diabetes-associated complications.

A method of preparing a composition for regulating animal growth comprising the steps of preparing cysteamine or its salt, and mixing the cysteamine or its salt with cyclodextrin or its derivative in a reactor.

The subject invention provides methods for improving livestock health. In specific embodiments, the invention provides methods for accelerating and / or augmenting livestock growth; improving immunity; and enhancing fertility in livestock. To do so, the present invention provides materials and methods for administering a cysteamine compound to livestock.

The invention discloses a high strength and high toughness self-repairing thermoplastic polyurethane urea elastomer and a preparation method thereof. The self-repairing thermoplastic polyurethane ureaelastomer is synthesized by double chain extension of prepolymers generated from diisocyanate and polyether diols separately in the presence of 2,6-diaminopyridine and cysteamine. A pyridine ligand unit is introduced onto a main chain, and coordination bonds are formed between molecular chains through the coordination effect of metal ions, thereby forming interchain reversible molecular healing;at the same time, the coordination bonds act as dynamic crosslinking points and achieve the effects of limiting molecular chain slip and improving mechanical properties; a disulfide bond is introducedinto a macromolecular main chain through double chain extension, and the self-healing ability is improved in an association manner through a reversible exchange reaction of the main chain. The elastomer has the self-repairing efficiency being more than 85%, the tensile strength being not less than 8 MPa and the toughness being not less than 40 MJ / m<3>. The elastomer is capable of both improving mechanical properties and self-repairing performance, can maintain the integrity and functionality of materials against complex deformation, and has extremely high application value in the field of flexible electronic equipment.

The invention belongs to the technical field of animal nutrition and feed, and especially relates to a total mixed ration for mutton sheep in?the fattening?period and a preparation method thereof. The total mixed ration for mutton sheep is characterized by comprising the following raw materials in percentage by weight: alfalfa hay 35.00-35.00%, yellow corn silage 8.00-12.00%, malt root 3.00-5.00%, corn 25.00-35.00%, bran 2.00-5.00%, soybean meal 6.00-12.00%, cottonseed meal 2.00-6.00%, yeast culture 0.20-0.60%, corn distiller's dried grains for feed 2.00-5.00%, coated calcium chloride 0.20-0.60%, calcium hydrogen phosphate 0.10-0.60%, sodium bicarbonate 0.10-0.40%, salt 0.10-0.50%, coated cysteamine 0.05-0.10%, a core premix 0.20-0.30%, a rumination composite enzyme 0.05-0.10%, stone powder 0.30-1.00%, and vegetable oil 0.50-1.00%. The total mixed ration has the following advantages that the immunity, the health level and the uniformity of mutton sheep in?the fattening?period are improved.

The invention discloses an ECL (electrochemiluminescence) immunosensor for detecting tumor markers and a preparation method and applications thereof. The immunosensor comprises a working electrode, a reference electrode and a counter electrode, wherein the working electrode is a gold electrode, cysteamine, glutaraldehyde, a tumor marker first-antibody, a tumor marker, and a composite functionalized nanosphere are sequentially decorated on the surface of the gold electrode, the composite functionalized nanosphere is simultaneously marked by a tumor marker second-antibody and an ECL marker, and non-specific active sites are closed by using bovine serum albumins. The preparation method comprises the steps of preparing the gold electrode on which the tumor marker first-antibody is fixedly carried; synthesizing the composite functionalized nanosphere simultaneously marked by the tumor marker second-antibody and the ECL marker; and finally, assembling the obtained gold electrode and the composite functionalized nanosphere into an ECL immunosensor. The ECL immunosensor disclosed by the invention is high in sensitivity, rapid in analysis speed, strong in stability and selectivity, good in reproducibility, easy to operate, and flexible in method.

The use of cysteamine, a salt thereof or a composition containing cysteamine or a salt thereof for improving lactation of lactating animals.

The invention discloses a preparation method for a porous monolithic column immobilized enzyme micro-reactor. The porous monolithic column immobilized enzyme micro-reactor is prepared according to the preparation method as follows: firstly, a poly (GMA-co-EDMA) monolithic column is prepared; and then the poly (GMA-co-EDMA) monolithic column is modified by cysteamine and gold nanoparticles so as to obtain a porous polymer monolithic column, wherein, the gold nanoparticles are immobilized on the surface of the porous polymer monolithic column. Enzyme is immobilized to the hole surfaces of the porous monolithic column modified by the gold nanoparticles by utilizing the action of Au-NH2 bond, and then the porous monolithic column immobilized enzyme micro-reactor can be obtained. The preparation method has the advantages as follows: the preparation method is simple; enzyme immobilization reaction conditions are moderate; the permeability of the enzyme micro-reactor is good; large immobilized enzyme quantity can be achieved; the activity, the service life and the stability of enzyme are high in comparison with free solution enzymolysis, and enzyme can be used repeatedly.

The subject invention provides materials and methods for treating various health conditions, including the prevention and / or treatment of a viral infection. In a preferred embodiment, a cysteamine compound is administered to a subject to treat an influenza virus infection. More preferably, a cysteamine compound is administered to a subject to treat influenza A, influenza B, influenza C virus infections, including avian influenza virus subtypes (such as H5N1 avian influenza virus).

Provided are hair processing agents capable of permanent waving hair even at a neutral to weakly acidic pH range that causes less irritation to the skin, and hair processing agents in which an unpleasant odor is masked. Hair processing agents contain at least one compound represented by the formula (2). Hair processing agents contain a compound of the formula (2) and at least one compound (ii) selected from thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine, salts thereof and ester derivatives thereof. Hair processing agents contain a compound of the formula (2), a surfactant and water, and are emulsified. Hair processing agents contain a compound of the formula (2) and a specific perfume. wherein X is a structure selected from —O—, —S—, —NH— and —NR1—; R1 is an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; in the formula (1), Z is a divalent organic residue having at least one mercapto group; in the formula (2), R is a divalent organic residue optionally having a mercapto group; and R2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms.

The present invention relates generally to the use of cysteamine or a cysteamine-containing composition for (I) increasing the yield and / or quality of eggs produced by fowls, (ii) preferentially promoting growth rate of female fowls over male fowls and / or (iii) preferentially promoting development of breast muscles of fowls over development of muscles other than the breast muscles. The invention also relates to a method and cysteamine-containing feed of raising fowls, and a method of preparing such feed.

The subject invention provides materials and methods for modulating a variety of biological factors to treat biological conditions associated with the factors. In one embodiment of the invention, a cysteamine compound is administered to a patient to treat hypercholesterolemia and / or complications associated with hypercholesterolemia. In another embodiment, a cysteamine compound is administered to a patient to prevent the onset of diabetes in an at-risk patient and / or treat or prevent the onset of diabetes-associated complications.

The invention discloses a method for synthesizing a dendritic macromolecule of polyester. The method comprises the following steps: reacting polyamine or polyalcohol and an ABx type asymmetrical monomer, repeatedly and alternately adding a CDy type asymmetrical monomer and the ABx type asymmetrical monomer, and preparing the dendritic macromolecule of polyester by the selective chemical reaction of the CDy type asymmetrical monomers and the ABx type asymmetrical monomers; selecting methacryloxypropyl ethyl acrylate or methacryloxypropyl propyl acrylate as the ABx type asymmetrical monomer, and cysteamine as the CDy type asymmetrical monomer; or selecting methacrylic acid isocyano ethyl ester as the ABx type asymmetrical monomer, and amino glycerol as the CDy type asymmetrical monomer. The method has the advantages of easy synthesis, simple product purification and the like; and the synthesized dendritic macromolecule of polyester can be biologically degraded and has good biocompatibility, and can be used as a biomedical material.

The subject invention provides materials and methods for treating various health conditions, including the prevention and / or treatment of a viral infection. In a preferred embodiment, a cysteamine compound is administered to a subject to treat an influenza virus infection. More preferably, a cysteamine compound is administered to a subject to treat influenza A, influenza B, influenza C virus infections, including avian influenza virus subtypes (such as H5N1 avian influenza virus).

The invention relates to a preparation method of a high-polymer viscosity reducer for heavy oil production. According to the preparation method, by utilizing cysteamine as a chain transfer agent, a macromolecule functional monomer containing various functional groups such as nitrogen heterocyclic rings, benzene rings and ethylene oxide chain segments is prepared, then the macromolecule functionalmonomer, acrylamide, vinyl pyrrolidone, acrylic acid and a 2-acrylamide-2-methylpropanesulfonic acid water-soluble monomer are taken as raw materials, and a water-soluble polymer with a comb-shaped functional structure is prepared through aqueous solution polymerization. The product has the good dissolving property in an aqueous solution, and the viscosity of heavy oil can be lowered significantly. In addition, oil-water separation is easy under still standing of a heavy oil viscosity-reducing sample, and produced liquid is convenient to treat.

A method of preparing a composition for regulating animal growth comprising the steps of preparing cysteamine or its salt, and mixing the cysteamine or its salt with cyclodextrin or its derivative in a reactor.

The invention belongs to the technical field of pig feed production, and in particular relates to a pig feed for promoting the oestrus of sows and improving the birth rate of piglets. The feed has the advantages that the sows are rapid in oestrus, short in period and multiple in piglets. The pig feed is composed of a conventional feed which promotes the oestrus of the sows and improves the birth rate of the piglets and Chinese herbal medicines, wherein the conventional feed consists of the raw materials of corns, bean pulp, extruded soybeans, import fish meal, corn gluten meal, peanut meal, bran, soybean oil, calcium hydrophosphate, mountain flour, boar multi-vitamins, multiple minerals, lysine, choline chloride and cysteamine; the Chinese herbal medicines consist of the raw materials of herba epimedii, actinolite, leonurus, Chinese angelica, semen cuscutae and nutgrass, and in the conventional feed, the addition amount of the Chinese herbal medicines accounts for 2.0-4.0% of the total amount of the feed. According to the feed, the medicine properties of the Chinese herbal medicines are utilized on the basis that the formula of the main ingredients is optimized, thereby improving the reproduction function of the sows, promoting the early oestrus of the sows and the birth of the multiple piglets, improving the reproduction capacity and the production property of the sows.

The subject invention provides methods for improving livestock health. In specific embodiments, the invention provides methods for accelerating and / or augmenting livestock growth; improving immunity; and enhancing fertility in livestock. To do so, the present invention provides materials and methods for administering a cysteamine compound to livestock.

The invention discloses a meat quality improver for grass carps and a preparation method for the meat quality improver. The meat quality improver is prepared from the following raw materials in part by weight: 5 to 10 parts of astragalus, 5 to 10 parts of Codonopsis pilosula, 10 to 15 parts of eucommia bark, 5 to 10 parts of lycopene, 1 to 5 parts of plumepoppy extract, 8 to 15 parts of phytase, 1 to 3 parts of cysteamine, 20 to 40 parts of lactosucrose and 20 to 40 parts of montmorillonite. The invention has the advantages that: active ingredients for improving the meat quality of freshwater fishes are scientifically matched; and the meat quality improver can remarkably improve the growth of cultured fishes and reduce the fat content of the fishes, and also improves the elasticity of muscle, chewiness, hardness and cohesion so as to ensure that the meat is fresh and delicious.

The invention relates to a new composition by slowing-releasing envelope with cysteamine or its saline compound. Said composition comprises: A, cysteamine or its saline compound in 1-95 wt %; main materials used for covering in 1-80 wt % which is mainly sodium alginate, polyacrylic resin II, polylactic acid, polyamino acid, corn zein plasm, poly(D.L-Lactide)-poly(ethylene glycol) block copolymer, crosslinked polyvinyl pyrrolidone, hydroxypropylmethylcellulose phtha late, polyvinyl acetate phthalic acid esters, cellulose ethyl ether, and succinic acetate methylcellulose. This invention also relates to process of slowing-releasing envelope on new compound with cysteamine or its saline, and its use as animal feedstuff additive. The strongpoint of said invention is the excellent effect on envelope; the available utilization by animals of envelope materials degraded in the inner body of animals; further, the reached slowing-releasing technique on the combined use of envelope materials which can express the biological value more effectively in inner body of animals.

The disclosure relates, in general, to treatment of fatty liver disorders comprising administering compositions comprising cysteamine products. The disclosure provides administration of enterically coated cysteamine compositions to treat fatty liver disorders, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

The invention relates to a feed for promoting estrus of boars, which belongs to the technical field of production of feeds for pigs and is used for promoting the estrus of boars and improving the boar sperm quality. The feed for promoting the estrus of the boars and improving the boar sperm quality can be used for improving the reproduction performance of boars of child-bearing age. The feed for promoting the estrus of the boars consists of a conventional feed and Chinese herbal medicines and is characterized in that the conventional feed consists of a premix feed consisting of corns, bean pulp, imported fish meal, corn gluten meal, bran, wheat middling, soybean oil, calcium hydrophosphate, mountain flour, salt, lysine, choline chloride and composite vitamins for boars, a composite microelement premix feed and cysteamine; the Chinese herbal medicines include fenugreek grass, actinolite, prepared rehmannia root, cynomorium songaricum and longspur epimedium. According to the feed, on the basis of an optimal formula, the medicine property of the Chinese herbal medicines is sufficiently utilized, the reproduction organism functions of the boars are improved, the estrus of the boars is promoted, the sperm quality of the boars and the reproduction performance of the boars of child-bearing age are improved and the economic benefit is increased.

A fish feeding composition for improving the growth and / or health of fish, comprises cysteamine or salts thereof and from 1 to 80 wt % of a carrier. The fish feeding composition is preferably added to a basal feed and then fed to the fish. Use of such a feed increases body weight and reduces death due to disease and adverse living conditions.

A composition for permanent hair shaping comprising: (i) about 0.5% by weight to about 30% by weight of a N-alkyl-2-mercaptoacetamide of formula or the salt thereof, wherein R1 is a straight chain alkyl residue with about 3 to about 6 carbon atoms or a straight chain hydroxyalkyl with about 3 to about 6 carbon atoms, R2 and R3 are, independently from each other, hydrogen or straight chain alkyl residues with about 1 to about 3 carbon atoms; (ii) about 0.1% by weight to about 20% by weight of at least one further hair keratin reducing agent selected from the group consisting of thioglycolic acid, thiolactic acid, 3-mercaptopropionic acid, 2-hydroxy-3-mercaptopropionic acid, cysteine, cysteamine, alkyl- or acylcysteamine with about 1 to about 4 carbon atoms in the alkyl residue, or the salt thereof; cysteine-(2-hydroxyethyl)ester, L-cysteine glycerine ester, and glycerine mono thioglycolate; and (iii) about 5% by weight to about 95% by weight of water and a method of permanently shaping hair using said composition.

The present invention provides a preparation method of a long-lasting antibacterial and anti-crease composite yarn. According to the method, since methylbenzene has a swelling effect for polyester fibers, GMA is subjected to interfacial free-radical polymerization on the surface of artificial fibers, and generated PGMA can be anchored on the surface of the artificial fibers, and therefore, epoxy groups can be led onto the surface of the fibers; through a grafting reaction, the epoxy groups react with amidogens on cysteamine, so that sulfydryl can be led onto the surface of the fibers; stable S-Ag bonds are formed between the sulfydryl and silver particles, so that composite nanoparticles can be immobilized on the surface of the artificial fibers; and the outer yarn body of the yarn is coated with titanium dioxide / nano silver composite nanoparticles, and the durability of the antibacterial property of the yarn can be improved through the synergistic effect of titanium dioxide and nano silver particles. The composite yarn produced by the preparation method of the invention has the advantages of excellent antibacterial performance and anti-crease effect as well as favorable fluffiness, flexibility and comfort, and excellent gas permeability and moisture absorption performance, and touches soft.

The invention discloses special non-resistant low-protein broussonetia papyrifera fermented feed for finishing pigs. The special non-resistant low-protein broussonetia papyrifera fermented feed is prepared from the following raw materials: maize, broussonetia papyrifera fermented materials, buckwheat short flour, soybean meal, cottonseed protein powder, grape seed meal, maize embryo meal, mulberryleaf powder, rock flour, 0.5 percent of composite multivitamins and composite multi-minerals for the finishing pigs, radix glycyrrhizae powder, feed-grade sodium chloride, acremonium terricola cultures, calcium hydrogen phosphate, coated cysteamine, chromium picolinate, meaical stone, expanded linseed, composite organic ferric agent, protease K, lactase, lysine, methionine, threonine, tryptophane, valine and sodium glutamate. The invention provides a preparation method of the special non-resistant low-protein broussonetia papyrifera fermented feed. The special non-resistant low-protein broussonetia papyrifera fermented feed and the preparation method of the special non-resistant low-protein broussonetia papyrifera fermented feed have the beneficial effects that by adopting the broussonetia papyrifera fermented feed, an utilization ratio of nutrient substances of feed raw materials can be increased, anti-nutrition factors are passivated, beneficial microorganisms are greatly bred and enriched, improvement and increase of quality of pork are promoted, a formula of the feed is reasonable, the cost is low, energy conservation and environmental protection are achieved, the growing-finishing effect is obvious, the pork is healthy, and the flavor is good.

The invention provides a spotted deer feed additive. The additive for basic feed comprises the following components by mass: 100 to 300 grams of complex enzyme, 250 to 2,000 grams of amino acid-trace element chelate, 35 to 55 grams of cysteamine, 500 to 800 grams of sodium chloride, 180 to 1,500 grams of vitamins, 1 to 2 kilograms of fish bone meal, 200 to 450 grams of astragalus root, 50 to 300 grams of sodium selenite-vitamin E premix, 20 to 60 grams of rock flour, 10 to 30 grams of zeolite powder, 10 to 20 grams of honey and 15 to 25 grams of carotene. The spotted deer feed additive is specially used in artificial raising and propagating of spotted deer. The additive has green, environmentally-friendly and pollution-free effects and effects of effectively balancing and coordinating with various nutrients in the feed and improving growth speed, feed utilization rate and productive performance. In the invention, expensive apparatuses are not used, the operation is simple, the use is convenient, the raw materials are readily available and the cost is low.

The invention relates to a blue fluorescent compound and a preparation method thereof. The method includes: taking citric acid, cysteine or cysteamine as the starting raw material, adding the citric acid and cysteamine or cysteamine derivative into a solvent, then carrying out condensation reflux reaction at 100-150DEG C for 1-12; and then performing natural cooling to room temperature, adding deionized water, conducting standing at 0-5DEG C to precipitate solid, filtering and drying the solid so as to obtain the blue fluorescent compound. According to the invention, the blue fluorescent compound is prepared by means of reflux heating, contains the active group carboxyl, emits blue fluorescence under ultraviolet excitation, and has very high quantum yield over 72%. The preparation method is simple and has mild synthesis condition, thus being easy for industrialization.

The invention discloses a non-toxic photoelectrochemistry competition immunoassay method of zearalenone based on a peptide sensor. According to a sensing interface building method, carbon nanohorns, cysteamine functional golden cone and polyglycine are used as substrates; corn zeranol antibodies (Ab) are further immobilized; tyramine functionalized nanometer rutile type TiO2 mesoscopic crystals are used for immobilizing peptide chains with the specific sequences as a photoelectric probe; the peptide chain has the effect of simulating the zearalenone, the zearalenone can compete with the markedphotoelectric probe to combine the corn zeranol antibodies immobilized on the sensing interface. The photoelectric probe combined onto the sensing interface can further combine with tyramine-Rutile TiO2 mesoscopic crystal compounds under the catalysis effect of horseradish peroxidase; optoelectronic signals can be further amplified. On the basis, the non-toxic photoelectrochemistry competition immunoassay method on the corn zeranol can be built.

The invention discloses a chemical synthesis method of valnemulin hydrochloride, which comprises the following steps of: taking refined pleuromutilin as raw material, carrying out sulfonation by paratoluensulfonyl chloride, and reacting with dimethyl cysteamine hcl, to obtain the pleuromutilin dimethyl cysteamine substitute; reacting D-valine, methyl acetoacetate and potassium hydroxide to obtain (R)-2-(1-methoxycarbonyl group-2-allyl) amino-3-methyl potassium butyrate, activating by ethyl chloroformate and reacting with the pleuromutilin dimethyl cysteamine substitute, adjusting PH value, carrying out reverse phase extraction, and carrying out freeze-drying to obtain the valnemulin hydrochloride. The method has the advantages that due to the refining of the raw material pleuromutilin, the impurities in the product can be effectively removed, and the purifying process can be simplified from the source; the carboxyl of D-valine can be activated by the ethyl chloroformate, so that the reaction is easier to carry out; and due to the pH adjustment, the reverse phase extraction, and the freeze-drying, the product can be obtained, so that the product is stable in quality, and high in purity.