38 results about "Cysteamine" patented technology

The invention relates to the technical field of organic polymer adhesives, and particularly discloses a modified castor oil-based polyurethane adhesive as well as a preparation method and application thereof. The adhesive comprises two components, and the component A comprises the following components in parts by weight: 30.0-50.0 parts of modified castor oil and 0.0-30.0 parts of refined castor oil; the component B is prepared from the following components in parts by weight: 30.0 to 50.0 parts of polyisocyanate or a polyisocyanate modifier and 0.00 to 0.05 part of a dewatering agent; the modified castor oil is prepared from refined castor oil and cysteamine through a sulfydryl-alkene addition reaction. Amido of the modified castor oil is alkalescent, and the reaction speed of the modified castor oil and isocyanate groups is high; hydrogen bonds are easily generated between urea bonds generated by the reaction of amino groups and isocyanate groups, so that the adhesive is endowed with thixotropy and high strength. The adhesive disclosed by the invention is simple in composition, high in reaction speed and good in thixotropy and bonding strength.

The invention discloses low-temperature anti-oxidation conductive copper paste, a preparation method and an RFID tag, and relates to the field of conductive paste. The modified copper powder comprises: copper powder; the cysteamine self-assembly molecular layer is formed by coupling sulfydryl of cysteamine with the surface of the copper powder; the metal phthalocyanine complex molecular layer is coordinated with central metal ions of metal phthalocyanine molecules through amino groups of cysteamine and is connected to the surface of the cysteamine self-assembled molecular layer; and the conductive copper paste is sintered at 140-170 DEG C. According to the low-temperature curing conductive copper paste, the problem of anti-oxidation defects of the copper powder can be effectively solved while the conductivity of the copper powder is ensured, and the low-temperature curing conductive copper paste with long-acting anti-oxidation performance and high conductivity is obtained.

Methods for producing organosulfur compounds from a prokaryotic cell comprising enzymes involved in the production of cysteamine, hypotaurine, and taurine. Said prokaryote may comprise a vanin selected from vanin-1 (vnn-1), vanin-2 (vnn-2), or vanin- 3 (vnn-3), a cysteamine dioxygenase (ado), and / or a flavin-containing monooxygenase 1 (fmo1). Methods include the expression of organosulfur compounds in Corynebacterium glutamicum with incubation conditions to promote compound production.

This invention discloses an in vitro maturation culture medium for ferret oocytes and its preparation method, belonging to the field of animal embryo engineering technology. It comprises the following components: TCM199 basal culture medium, 50 mL fetal bovine serum, 25 IU follicle-stimulating hormone, 25 IU luteinizing hormone, 0.5 mg 17β-estradiol, 0.005 mg epidermal growth factor, 12.1 mg sodium pyruvate, 0.2 mM cysteine, 0.1 mM cysteine, 0.030 g penicillin, 0.025 g streptomycin sulfate, as well as an antioxidant complex, a combination of growth factors, and extracellular matrix components. This invention provides a comprehensive and suitable nutritional environment for ferret oocytes by precisely formulating a composite culture medium containing multiple key components. Specifically, the hormone combination at specific concentrations accurately simulates the in vivo physiological environment, effectively regulating the oocyte maturation process; multiple growth factors work synergistically to promote oocyte growth, development, and differentiation; and the addition of the antioxidant complex effectively eliminates free radicals generated during in vitro culture, reducing oxidative stress damage to oocytes.

Provided herein are methods for the treatment, mitigation, and prevention of viral infections (e.g., coronavirus infections (e.g., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), etc.), etc.) and diseases (e.g., Coronavirus disease 2019 (COVID-19)) associated therewith by the administration of cysteamine or derivatives thereof to a subject.

The application relates to a gold nanoparticle array preparation method with strong stability and reusability, high cysteamine-stabilized gold nanoparticles are prepared first, the spacing between the gold nanoparticles is changed by utilizing the coulomb repulsion between the gold nanoparticles, then the gold nanoparticle solution is added dropwise to a glass surface modified by gamma-glycidoxypropyltrimethoxysilane to react, stable covalent bonds are formed, and gold nanoparticle arrays with uniform distribution on the glass surface can be obtained after the reaction. The preparation does not require high temperature, the experimental operation is simple and convenient, the gold nanoparticles are arranged in order and closely, have high detection sensitivity, have strong ultraviolet absorption capacity, good stability, reusability, salt resistance and low background interference, and can be reused. The gold nanoparticle array can realize detection analysis on high-salt-content samples in surface-assisted laser desorption ionization mass spectrometry and be used for rapid analysis of small molecule compounds in positive and negative ion dual modes.

A genetically modified prokaryotic cell to express enzymes involved in the production of taurine. Said prokaryote comprises a vanin selected from: vanin- 1 (vnn-1), vanin-2 (vnn-2), or vanin- 3 (vnn-3), a cysteamine dioxygenase (ado), and a flavin-containing monooxygenase 1 (fmol), in addition to either the addition, alteration, or deletion of at least one gene involved in taurine synthesis or transport.

The present application relates to a kind of bimetallic copper palladium nanoscale enzyme and its preparation method and application, the bimetallic copper palladium nanoscale enzyme surface is decorated with cysteamine.The bimetallic copper palladium nanoscale enzyme described in the present application can be enriched in tumor site by passive targeting, can be used as radiotherapy sensitizer to inhibit the radiotherapy resistance of tumor, and improve the treatment effect of radiotherapy.

The invention relates to ophthalmic compositions comprising thiol drugs, such as cysteamine, for the prevention and / or treatment of ocular conditions related to the hardening and / or opacification of the crystalline lens of the eye; for instance, ocular conditions such as cataracts and presbyopia.

The invention provides a method for determining cysteamine chelated zinc in premixed feed, and belongs to the technical field of analysis and detection. The invention provides a method for determining cysteamine chelated zinc in premixed feed, which comprises the following steps: preparing a cysteamine chelated zinc sample to obtain a near-infrared analysis and prediction sample set; performing first near-infrared analysis on the near-infrared analysis prediction sample set, and obtaining a calibration model according to obtained data; performing second near-infrared analysis on the premixed feed to obtain data of the sample to be detected; the premixed feed contains cysteamine chelated zinc; and obtaining the content of cysteamine chelated zinc in the premixed feed according to the data of the sample to be detected and the calibration model. The determination method provided by the invention has the advantages of no damage, high efficiency, low cost, environmental protection and accurate result.

The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

The present disclosure relates to use of cysteamine, formulations comprising cysteamine and pharmaceutically acceptable salts of cysteamine in the treatment of cystic fibrosis and conditions associated with cystic fibrosis.

The present invention relates to a composition comprising cysteamine, azabenzene-4-carboxamide and glycolic acid. The present invention also relates to the cosmetic use thereof for inhibiting, reducing or preventing skin pigmentation and to the therapeutical use thereof for inhibiting, reducing or preventing skin hyperpigmentation diseases or disorders.

The application discloses a kind of disulfide crosslinked starch-based micelles and its preparation method and application.The preparation method includes: using pullulanase to carry out branch removal treatment to waxy corn starch, and prepare dextrin;Using periodate on the dextrin is oxidized, and prepare dialdehyde dextrin;Make cysteamine and the dialdehyde dextrin grafting reaction, and prepare cysteamine-dextrin;The cysteamine-dextrin is dissolved in water and self-assembled to form micelles, then ultrasonic sulfhydryl oxidation is carried out, and prepare disulfide crosslinked starch-based micelles.The disulfide crosslinked starch-based micelles provided by the application with hydrophobic functional factor has higher hydrophobic functional factor loading and environmental stress stability, in vitro simulation release presents colon targeting, and has wide application prospect in the field of oral delivery of hydrophobic functional factor.

The invention discloses a stable paper-based SERS (Surface Enhanced Raman Scattering) substrate as well as a preparation method and application thereof, and belongs to the technical field of detection, filter paper is immersed into a KH-560 aqueous solution, dried at room temperature for 30-60 minutes and then immersed into a cysteamine aqueous solution, and thiol modified filter paper is obtained; agNPs sol, a tetrabutylammonium nitrate aqueous solution and dichloromethane are evenly mixed, AgNPs are arranged into a single layer on a water-gas interface, then cyclohexane is added, AgNPs are migrated to a water-cyclohexane interface, and a densely-stacked silver nanoparticle single layer is generated; after cyclohexane is removed, thiol modified filter paper is immersed below the silver nanoparticle single layer and then taken out to form the stable paper-based SERS substrate, and the stable paper-based SERS substrate is high in stability and reproducibility and can be used for rapid, accurate and trace detection of methylene blue in a water body.

The invention discloses an unmarked quantum dot electrochemical luminescence sensing electrode for detecting mycotoxin as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing an interdigital electrode pair with two groups of independent detection channels on a glass substrate; self-assembling cysteamine on the surface of the gold working electrode to form an amination interface; sequentially carrying out covalent immobilization on the ZnCdS (at) ZnS quantum dots and different fungaltoxin aptamers through amidation reaction; and finally, sealing by using bovine serum albumin. The prepared sensing electrode has a unique complementary segmented interdigital structure, comb tooth parts of the gold working electrode and the platinum counter electrode are arranged in a staggered and non-contact manner, and annular parts are arranged in a concentric circle manner, so that electric field interference between channels is effectively avoided. The invention further provides application of the electrode, chemical labeling is not needed in the whole process of the method, high-sensitivity, high-specificity and parallel in-situ detection of high-harm mycotoxins such as ochratoxin A and zearalenone is achieved, the integration level is high, and the electrode is suitable for on-site rapid screening of food safety.

This document provided ocular delivery systems for treatment of cystinosis as well as methods for making such ocular delivery systems and methods for using such ocular delivery systems. For example, ocular delivery systems designed to include spray-dried, cysteamine-loaded microparticles suspended in a thermoresponsive gel are provided herein.

The invention discloses a preparation method of an alloy stent with a composite coating, and relates to the technical field of medical alloy stents. According to the technical scheme, hexadecyl trimethyl ammonium bromide is used as a template, mesoporous silica nanoparticles are prepared through hydrolytic condensation and hydrochloric acid-methanol template removal, after a drug is loaded, chitosan is used for coating, cysteamine is combined to introduce a disulfide bond, and pH / oxidation dual-response drug-loading particles are constructed; finally, the alloy stent serves as a working electrode, the calcium-phosphorus coating drug-loaded stent is prepared through electro-deposition, precise slow release of drugs is achieved, and treatment safety and effectiveness are improved.

The application relates to the technical field of poultry feed additive preparation, in particular to application of cysteamine or a salt thereof in preparation of a feed additive for preventing and improving fatty liver of laying hens. The application provides application of cysteamine or a salt thereof in preparation of a feed additive for preventing and improving fatty liver of laying hens. The application provides a new use of cysteamine and a salt thereof in preparation of a feed additive for preventing and improving fatty liver of laying hens, and provides a new way for preventing and improving fatty liver of laying hens.

The invention provides a masking agent, a masking method for applying reaction odor, a hair texturing agent, a hair cosmetic for perm, a method for producing the same, and a perfume composition used in the same. The present invention relates to a hair texturing agent capable of masking a strong reaction odor caused by a plurality of different types of causative substances, which is generated during application of a mercaptoacetic acid-based and cysteamine-based hair texturing agent to hair and remains for a few days after application. A masking agent for an odor from a hair texturing agent, said masking agent containing one or more types of perfume selected from the group consisting of (E, E)-2, 4-heptadienal, 3-mercapto-3-methylbutanol, 4-ethylguaiacol, and carvacrol. It is preferable that the perfume contains at least one perfume selected from the group consisting of acetophenone and methyl octyl ketone.

The invention relates to specific polyglycerol derivatives and their further medical uses, namely to dPG / lPG-DTBA and dPG / lPG-cysteamine. These polyglycerol derivatives have a linear or dendritic polyglycerol backbone and carry at least one thiol group covalently bound to the polyglycerol backbone. The claimed medical uses are the use as mucolytic; the use in treating chronic sinusitis, asthma, chronic bronchitis, cystic fibrosis, chronic obstructive pulmonary disease, emphysema, or bronchiectasis; and the use in treating chronic inflammatory bowel diseases, constipation, gastrointestinal malabsorption syndrome, irritable bowel syndrome, steatorrhea or diarrhea.

Provided herein are methods for the treatment, mitigation, and prevention of viral infections (e.g., coronavirus infections (e.g., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), etc.), etc.) and diseases (e.g., Coronavirus disease 2019 (COVID-19)) associated therewith by the administration of cysteamine or derivatives thereof to a subject.

The application relates to the technical field of organic polymer adhesives, and particularly discloses a modified castor oil-based polyurethane adhesive as well as a preparation method and application thereof. The adhesive is a two-component adhesive, wherein, according to weight fractions, the A component is modified castor oil 30.0-50.0 parts and refined castor oil 0.0-30.0 parts; the B component includes polyisocyanate or polyisocyanate modifier 30.0-50.0 parts and water removal agent 0.00-0.05 parts; and the modified castor oil is prepared from refined castor oil and cysteamine through a mercapto-alkene addition reaction. The amine group of the modified castor oil is weakly alkaline, and the reaction speed with the isocyanate group is fast; hydrogen bonds are easily generated between the urea bonds generated by the reaction of the amine group and the isocyanate group, so that the adhesive is endowed with thixotropy and high strength. The adhesive has simple composition, fast reaction speed, good thixotropy and bonding strength.

This invention discloses a perming composition based on thermosensitive regulation, comprising the following components: an aqueous phase including disodium EDTA, urea, glycerin, methylparaben, propylparaben, and phenoxyethanol; a reducing buffer phase including cysteine ​​hydrochloride, cysteine, sodium bicarbonate, ammonium carbonate, and ammonia; an emulsified oil phase including caprylic / capric triglyceride, polydimethylsiloxane, sodium lauroyl glutamate, cocamidopropyl betaine, and PEG-40 hydrogenated castor oil; an active repair phase including phosphatidylcholine, hydrogenated lecithin, ceramide, tocopherol, ascorbyl palmitate, ethoxydiethylene glycol, p-hydroxyacetophenone, and 1,2-hexanediol; a conditioning and repair phase including hydrolyzed keratin, arginine, methylisothiazolinone, and a daily fragrance; and the remainder being deionized water. This invention simplifies the judgment and operation process of softening through the synergistic effect of thermosensitive regulation and the cysteine-based reducing system. This invention also includes a method for preparing the perming composition.

The invention features methods for the treatment of cystinosis and other cysteamine sensitive disorders in a subject including administration of a disulfide convertible to cysteamine in vivo. The methods can include the separate administration of a reducing agent to the subject to increase the bioavailability and extend the plasma pharmacokinetic profile of the cysteamine produced following administration of the disulfide. The methods permit sustained cysteamine plasma concentrations in a subject.

The invention relates to an electrochemical molecularly imprinted sensor and a preparation method thereof, and the preparation method comprises the following steps: pretreating an electrode, constructing a cysteamine self-assembled membrane (SAM) to form a positively charged monomolecular layer on the surface of the electrode, and efficiently capturing negatively charged template protein with an isoelectric point of less than 7.4 by using electrostatic attraction; then, an aromatic amine functional monomer is subjected to in-situ electropolymerization on the surface of the electrode, the amino group of the functional monomer and the amino group of cysteamine SAM are subjected to graft copolymerization to form a polymer film layer which is anchored through a covalent bond and wraps the template protein, and a specific cavity is formed through elution. The cysteamine SAM not only solves the problem of electrostatic repulsion between template protein and a bare electrode and improves the fixed quantity and effective imprinting sites, but also enhances the adhesive force of a polymer film, and a short-chain structure guarantees the electron transmission efficiency. The preparation process is simple and convenient, parameters are controllable, the sensor sensitivity and stability are excellent, various low-isoelectric-point proteins can be efficiently detected, and the method is suitable for the fields of biomedicine, environmental monitoring and the like.

This invention provides a method for treating cysteamine sensitivity disorders in the target population. [Solution] A method is provided for the treatment of cystinosis and other cysteamine-sensitive disorders in a subject, comprising the administration of a disulfide convertible to cysteamine in vivo. The method may include separately administering a reducing agent to the subject to enhance the bioavailability of cysteamine produced after disulfide administration and to extend the plasma pharmacokinetic profile. The method allows for sustained plasma cysteamine concentrations in the subject. In one embodiment, compound (1) is administered at a dose of 50-150 milligrams / kilogram of body weight (mg / kg), TIFF2026065004000032.tif23170 A method is provided which includes administering to the subject at least once a day a pharmaceutically acceptable salt thereof.

The application discloses a mercury ion detection method. The detection method mainly comprises preparation of mercapto carbon dots, preparation of a graphene transistor sensor, modification of the graphene transistor sensor by the mercapto carbon dots, and detection of mercury ions by the sensor, etc. In the application, the mercapto carbon dots are modified to the gate of the graphene transistor sensor by cysteamine, the specific chelation between the mercapto functional groups in the mercapto carbon dots and mercury ions is utilized, a stable mercury ion-mercapto functional group-carbon dot structure is formed on the gate surface, the original double electric layer structure of the sensor is changed, the graphene channel current is changed, and the purpose of detecting mercury ions is achieved. By constructing the graphene transistor sensor detection platform functionalized by the mercapto carbon dots, specific label-free detection of mercury ions is realized, trace detection of mercury ions is realized, and the minimum detection limit reaches 10 ‑17 M, linear detection range 10 ‑16 M-10 ‑8 M, and the detection time is within 1 min, and the operating voltage is lower than 1 V. Compared with the prior art (fluorescence, colorimetric technology, etc.), the detection method provided by the application is simple in operation, low in cost, sensitive in detection, high in accuracy, and can realize detection of mercury ions in actual environmental water samples. Meanwhile, the application has great application prospect in food safety detection and biological health detection.

Compositions for skin creams and serums are provided for treating skin hyperpigmentation, the compositions including cysteamine, tranexamic acid, niacinamide, tetrapeptide 30, DNA repair enzymes, and human growth factors. A formulation for the skin cream or serum includes 5% cysteamine by weight, 5% tranexamic acid by weight, 4% niacinamide by weight, 1% tetrapeptide 30 by weight, in which the tetrapeptide 30 includes the following four amino acids linked together: L-prolyl-L-lysyl-L-alpha-glutamyl-L-lysine. In addition, the cream or serum includes DNA repair enzymes, including 1% phytosomes, 0.3 to 1% roxisomes, and 1% ultrasomes. Further, the composition may include recombinant human growth factors.