3 results about "Cimetidine" patented technology

This invention relates to the field of viral inhibitor technology, and more particularly to the application of compounds targeting 3CLpro in inhibiting porcine reproductive and respiratory syndrome virus (PRRSV). Using 3CLpro as a target, this invention comprehensively screened various compounds against PRRSV and coronaviruses, discovering that compounds targeting 3CLpro exhibit varying degrees of inhibitory effects on both PRRSV and coronaviruses. In particular, cimetidine, LLY-507, and flupentixol hydrochloride all demonstrate significant anti-PRSV activity. Furthermore, in addition to targeting 3CLpro, LLY-507 and flupentixol hydrochloride may also act on other cellular targets to inhibit PRRSV replication. The three compounds provided by this invention show promising application prospects in the development of anti-PRRSV drugs.

The present invention relates to a pharmaceutical composition for preventing or treating melanoma, comprising cimetidine as an active ingredient, and, more specifically, to a pharmaceutical composition for preventing or treating melanoma, comprising cimetidine and at least one antibody selected from the group consisting of an anti-CTLA-4 antibody and an anti-PD-1 antibody as active ingredients. The present invention can provide a pharmaceutical composition for treating melanoma in which a melanoma treatment effect is increased using cimetidine and an antibody in a combination therapy, and optimized antibody capable of maximizing the melanoma treatment effect during the combination therapy has been identified. In addition, the pharmaceutical composition of the present invention can be specifically applied to melanoma cells to maximize a melanoma treatment effect while minimizing immune-related side effects.

The utility model discloses a trough type mixer convenient for discharging cimetidine tablets, which is characterized in that the upper surface of a trough type mixing barrel is fixedly connected with a stirring motor, the output end of the stirring motor is fixedly connected with a stirring rod, one end of the stirring rod penetrates through a top cover of the trough type mixing barrel and is fixedly connected with a stirring connecting rod, and the other end of the stirring connecting rod is fixedly connected with a stirring motor. A grinding block is fixedly connected to the bottom end of the stirring connecting rod, a grinding plate is fixedly connected to the bottom face of the groove-shaped mixing barrel, a hollowed-out groove is formed in the connecting position of the outer edge of the grinding plate and the inner wall face of the groove-shaped mixing barrel, and two vibration motors are fixedly connected to the bottom face of the groove-shaped mixing barrel; a discharging port is formed in the center of the grinding plate, an electromagnetic valve is fixedly connected to the bottom face of the discharging port, materials are refined and mixed, rapid caking caused by different characteristics of different materials is prevented, the quality of final products is improved, the time of the whole production process is shortened, and the production efficiency is improved.