149 results about "Cimetidine" patented technology

A stick of gum is provided containing therapeutic benefits of non-steroid anti-inflammatory drugs for inflammation in conditions such as arthritis, and also alleviates subsequent side effects of NSAID administration, as well as antacid effects from compounds such as an H2 antagonist (ranitidine, cimetidine, famotidine) and / or a proton pump inhibitor (such as lansoprazole, pantoprazole, omeprazole, esomeprazole or rabeprazole) and / or an acid pump antagonist selected from the group of soraprazan, AZD0865, YH1885 and CS-526.

The present invention provides methods for treating or preventing periodontal disease in a mammal subject. The inventive methods comprise topically administering to the subject an effective amount of a H2 antagonist encapsulated in liposomes. Preferably, the H2 antagonist, for example, Cimetidine, is encapsulated into paucilamellar liposomes, such as Novasome® microvesicles. The inventive methods may be used to treat and / or prevent gingivitis, periodontitis, aphthous ulcers, or herpetic stomatitis. Alternatively, the inventive methods may be used to treat and / or prevent a systemic disease associated with periodontal disease, such as cardiovascular diseases, pregnancy complications, and diabetes.

The invention relates to environmental improved compound functional additive specially used for livestock and poultry, and the preparation and application thereof. The weight composition of the additive is as follows: 5 percent to 10 percent of yucca extract, 15 percent to 30 percent of oligomeric isomaltose, 40 percent to 60 percent of sodium turface, 3 percent to 6 percent of lactobacillus dry powder, 3 percent to 10 percent of liquorice extract, 3 percent to 6 percent of cimetidine and 5 percent to 12 percent of lycine. The prescription of the invention is scientific, high-efficiency, safe and environment protective. The physiological characteristics and the growth demand of the livestock and poultry are fully considered, and the regulation to the livestock and poultry environment is conducted from all aspects, such as elevating the feed safety, improving the physiological functions of the digestion system of the livestock and poultry, inhibiting urease activity, absorbing all harmful components, etc. and has more obvious effect.

The invention relates to a method using alkaline hydrolysis to prepare cysteamine hydrochloride, in particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that: ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride. The preparation method for cysteamine hydrochloride by using alkaline hydrolysis has the advantages of simple method, short production period and low production cost. The recovery rate of synthesizing Alpha -mercaptothiazoline reaches more than 90%. The cysteamine hydrochloride can be widely applied in manufacturing anti-ulcer drugs such as ranitidine and cimetidine, manufacturing animal fodder additive, manufacturing cosmetic and hair wave-setting agent, manufacturing biochemical reagent and heavy metal ion complexion agent and manufacturing agent treating radiation syndrome and acute tetraethyl lead poisoning and in other areas.

The invention discloses a preparation method of cimetidine. The method comprises the following steps: (1) carrying out condensation reaction on 2-(methylimidazole-4-yl) methyl thioethylamine and N-cyanamide dialkyl carbonate in hot alcohol dehydratum, distilling out alcohol at ordinary pressure, cooling to a room temperature, crystallizing and filtering to obtain N-cyanogroup-N'-[2-(5-methylimidazole-4-yl) sulphur methyl ethyl]-O-R isourea; (2) carrying out amination reaction on the N-cyanogroup-N'-[2-(5-methylimidazole-4-yl) sulphur methyl ethyl]-O-R isourea and methylamine in a reaction medium, after reaction is ended, distilling methylamine at ordinary pressure, cooling to room temperature and crystallizing to obtain a cimetidine crude product; and (3) decoloring the cimetidine crude product in absolute ethyl alcohol, cooling, crystallizing, drying in vacuum, and crushing to obtain a cimetidine refined product. According to the preparation method, the environment pollution caused by by-product methyl mercaptan / sodium methyl mercaptide in an existing cimetidine production process can be solved; the production process is simplified; the cost is reduced; and the product quality is improved.

The invention relates to the technical field of biomedicine, in particular to a cimetidine synthesis process. The cimetidine synthesis process has high efficiency, damage to the human body and the environment can be reduced, and meanwhile the synthesis cost can be reduced. The synthesis process comprises the following steps: (1) mixing a first intermediate with a photocatalyst, and dissolving theobtained mixture in a reaction solvent; (2) adding a second intermediate to the reaction solution obtained in the step (1), and performing uniform mixing so as to obtain a clear solution; (3) using alight source to irradiate the clear solution obtained in the step (2), and performing coordinated stirring until it is shown through HPLC that the first intermediate reacts completely; and (4) performing concentration treatment so as to remove the solvent after completion of the reaction, and performing recrystallization by using water and isopropanol or ethanol so as to obtain cimetidine white powder.

The invention relates to a chewing gum for preventing and treating oral ulcer after chemotherapy. The chewing gum is composed of chewing gum ingredients and drugs used for preventing and treating oral ulcer. Each 100 g of the chewing gum for preventing and treating oral ulcer after chemotherapy comprises the following drugs used for preventing and treating oral ulcer: 5 to 10 mg of a recombinant human granulocyte colony stimulating factor, 5 to 10 mg of folic acid, 5 to 10 mg of metronidazole, 20 to 50 mg of lidocaine, 5 to 20 mg of cimetidine and 2.5 to 10 mg of vitamin B2, with the balance being the chewing gum ingredients. The chewing gum ingredients comprise, by weight, 25 to 30% of an edible gum base, 20 to 25% of maltose syrup, 35 to 45% of xylitol and 10 to 20% of sorbitol. The chewing gum provided by the invention can effectively prevent and treat oral ulcer resulting from different causes after chemotherapy, mitigate stimulation of the drugs on gastrointestinal tracts, reduce occurrence of adverse reactions and improve safety, has good taste and is convenient to take.

The present invention relates to medicine, and especially a kind of acne treating medicine and its preparation process. The acne treating medicine includes dephenhydramine, cimetidine, dexamethasone, metronidazole, spironolactone, salicylic acid and astragalus root in certain weight proportion as main ingredients, and has also the supplementary material including 50% concentration alcohol solution, aloe juice, glycerine and essence in certain proportion. Clinical application shows that the acne treating medicine has the advantages of high absorption, no blocking of pores, fast acting, high treating effect, etc.

The invention discloses a waste gas treatment and methyl mercaptan recycling process in cimetidine and ranitidine production. The waste gas treatment and methyl mercaptan recycling process comprises the following steps: (1) introducing waste gas in the production process of cimetidine and ranitidine into a washing tank, controlling pressure to 0.2-0.3MPa, removing volatile substances which are low in boiling point and easily soluble in water in the waste gas; (2) introducing the waste gas subjected to washing treatment into an alkaline washing tank, controlling pressure to 0.2-0.3MPa, removing volatile substances which are insoluble in water and soluble in alkaline by alkaline liquor in the alkaline washing tank; (3) introducing the waste gas subjected to the alkaline washing into a three-stage absorbing device, removing methyl mercaptan in the waste gas to generate sodium thiomethoxide; and (4) introducing the waste gas subjected to the three stages of absorption into a hydrogen peroxide falling film absorbing tower for performing oxidation treatment, and then discharging. According to the waste gas treatment and methyl mercaptan recycling process, useful chemical raw materials in the waste gas are recycled on the basis of solving the problem of waste gas emission, and thus the waste gas is prevented from being discharged, the economic benefit is increased, a new value is created, and the recycling economy is realized. The waste gas treatment and methyl mercaptan recycling process is good in application prospect.

The invention relates to a compound preparation for preventing and treating respiratory diseases of livestock and poultry, which is characterized by being prepared by uniformly mixing the following components by taking 100 grams as unit weight: 2-5 grams of cefixime sodium, 10-30 grams of doxycycline hydrochloride, 5-10 grams of rifampicin, 5-20 grams of cimetidine, 2-10 grams of ndometacin sodium, 2-6 grams of propolis powder, 2-6 grams of muramyl dipeptide and the balance of pharmaceutically applicable auxiliary materials, wherein the pharmaceutically applicable auxiliary materials are anhydrous glucose or oral glucose, preferably the anhydrous glucose. The compound preparation is compounded by antibiotic drugs, antiviral drugs, immunopotentiator and mucosa repair factors and has efficient and fast cure effect on respiratory symptoms of the livestock and the poultry, easy preparation, obvious effect and wide application range.

The invention relates to a chewing gum for preventing and treating oral ulcer resulted from chemotherapy and a preparation method of the chewing gum. The chewing gum comprises chewing gum ingredients and medicaments for preventing and treating oral ulcer; every 100 grams of chewing gum for preventing and treating oral ulcer comprise the following medicaments for preventing and treating oral ulcer by weight: 5mg-10mg of recombinant human granulocyte colony-stimulating factors, 5mg-10mg of folic acid, 5mg-10mg of metronidazole, 20mg-50mg of lidocaine, 5mg-20mg of cimetidine, 2.5mg-10mg of vitamin B2, and the balance being chewing gum ingredients. The chewing gum ingredients comprise the following components in percentage by weight: 25%-30% of edible gum base, 20%-25% of malt syrup, 35%-45% of xylitol and 10%-20% of sorbitol. The chewing gum disclosed by the invention can be used for effectively preventing and treating oral ulcer resulted from different disease causes after chemotherapy, further can be used for reducing stimulus of medicaments to gastrointestinal tract, reducing adverse reactions and increasing safety. Moreover, the chewing gum is good in mouth-feel and convenient to take.

The invention relates to cimetidine injection. Each 100 milliliter of cimetidine injection comprises components of 10-20g of cimetidine, 20-40g of cosolvent, 0.2-04g of antioxidant and 0.2-1.0 g of chelating agent. The cosolvent, the antioxidant and the chelating agent are added into the cimetidine serving as the essential component so that homogeneous and stable colorless transparent injection solution is formed. The injection is stable in characters after long-term preservation, has high content of active ingredients and is convenient and safe to use. The single injection quantity is increased greatly, injection frequency is lowered, and injury to animal bodies due to frequent injection is avoided.

The invention discloses a compound external anti-ulcer tablet which is characterized by comprising the following components by percent: 15 percent of oxytetracycline, 15 percent of berberine, 10 percent of compound sulfamethoxazole, 10 percent of metronidazole, 15 percent of complex vitamin B, 15 percent of vitamin C, 10 percent of cimetidine, 7 percent of calcium and 3 percent of chlortrimeton. The compound external anti-ulcer tablet solves the problems that an existing external anti-ulcer tablet cannot be used for treating skin membrane ulcer such as bedsore, scald, and non-cicatrization of wounds, and is applicable to treatments of various infantile febrile convulsion patients.

The invention discloses a compound medicine for preventing and treating enteritis of poultry, which contains the following constituents by mass percent: 10-40% of antibiotics, 0.1-1% of obstruent, 2-12% of intestinal mucosa protector, and the balance of auxiliary material. The antibiotics constituent in the compound medicine is one or more of aminoglycosides, polymyxins and berberine hydrochloride. The obstruent is one of scopolamine methobr, atropine, diphenoxylate, loperamide and bismuth subnitrate, or combinations of more. The intestinal mucosa protector is one of vitamin K3, cimetidine and glutamine, or combination of more. The auxiliary material is one of oral glucose, anhydrous glucose, soluble starch, dextrin and cyclodextrin, or combination of more. The invention further discloses a preparation method of the compound medicine for preventing and treating enteritis of poultry.

The invention discloses a medicament for treating flat wart. The medicament consists of weeping forsythia, honeysuckle flower, isatis root, red paeony root, indigowoad leaf, baikal skullcap root, dahurian patrinia herb, common burreed rhizome, curcuma zedoary, coix seed, paris rhizome, virgate wormwood herb, wild chrysanthemum and bunge corydalis herb. The aim of curing can be fulfilled by decocting the medicaments with water, meanwhile applying western medicines, including cimetidine and persantine, and taking three times every day for 2-3 treatment courses. The medicament disclosed by the invention has the effects of clearing away heat and toxic materials and promoting blood circulation by removing blood stasis, has high curative rate and low recurrence rate when used for treating the flat wart, and has the total effective rate being up to 97.6 percent.

The invention relates to cimetidine instant granules comprising following mixed components, by weight, 10-20 parts of cimetidine, 30-40 parts of disintegrant, 20-40 parts of humectant, 2-10 parts of corrective and 10-20 parts of excipient. The cimetidine instant granules are prepared by mixing the cimetidine, the disintegrant, the humectant and the excipient. Evidenced by experiments, the cimetidine instant granules have the advantages of high stability, good taste, edible easiness for animals, convenience in utilization and good therapeutic effect, can be stored for a long time, and has effective amount higher than that of existing injection.

The invention relates to compound Yushang ointment, which is characterized by being prepared from the following ingredients: 6.7 percent of terramycin, 6.7 percent of berberine, 6.7 percent of Yunnan Baiyao, 3.3 percent of metronidazole, 3.3 percent of vitamin C, 3.3 percent of cimetidine, 2.3 percent of vitamin B complex, 1 percent of borneol and 66.7 percent of vaseline. The compound Yushang ointment solves the problem of poor effect of the existing external ointment for treating anorectal disease pain and itch and chapped skin, and is suitable for patients with anorectal itching, anal fissure and chapped skin to use in a smearing way.

The invention provides a preparation method of high-potency positive serum for a porcine pseudorabies virus. The method takes a rabbit as an immunization object, and immunizes the rabbit with an inactivated vaccine containing a suitable amount of PolyI:C, muramyl dipeptide and cimetidine to produce the hyperimmune serum, can achieve the effect that no cytopathic effect occurs in subculture of at least 2 generations in a T25 square flask equal volume ratio neutralization 1 vaccine experiment, and meets the requirement that a cell method serves as an exogenous virus detection standard in the <Chinese veterinary pharmacopoeia> (2015 edition). The preparation method of the high-potency positive serum for the porcine pseudorabies virus has a good application prospect.

The invention discloses a method for detecting ranitidine hydrochloride, cimetidine, famotidine, nizatidine and lafutidine. The method comprises the following steps: (1) selecting chromatographic conditions; (2) selecting mass spectrometric conditions; (3) preparing a standard solution; (4), preparing samples; (5), detecting and calculating. Tests prove that the method is rapid and high in specificity; the method is suitable for detecting the illegally added ranitidine hydrochloride, famotidine, lafutidine, nizatidine, cimetidine and other chemical medicines in Chinese patent medicines and health-care foods which have the effects of invigorating the stomach, improving the gastrointestinal function (having an auxiliary protection effect on gastric mucosal injury) and having an auxiliary protection effect on gastric mucosal injury or in other foods illegally claimed to have said functions.

The invention discloses a composite medicine for treating acne, which is prepared by the steps of: crushing lightyellow sophora root, china root, flos lonicerae, common burreed rhizome, zedoary, aristolochiae lignum, Chinese rhubarb, radix angelicae pubescentis, spreading hedyotis herb and mongolian dandelion herb into fine powder, and adding cimetidine for mixing to prepare capsules. The Chinese medicinal herbs are matched in the cimetidine, so that the composite medicine has a remarkable treatment effect on the acne and is proved by clinical experiments to reach a total effective rate of 93.3 percent.

The invention provides a cimetidine sodium chloride injection production method capable of preventing impurities from exceeding the standard, belongs to the technical field of medicines and mainly solves the problem that impurities in finished cimetidine sodium chloride injection products in the prior art exceed the standard. The method is characterized by comprising the three following steps: 1)concentrated preparation; 2) diluted preparation; 3) sterilization. The method specifically comprises the following steps: injecting injection water into a concentrated preparation tank, putting 2 kgof cimetidine and 9 kg of sodium chloride, performing stirring, starting a circulating pump in a diluted preparation tank, circulating a solution by a fine filter provided with a 0.45 mu m polyether sulfone filter element, adjusting the pH by a hydrochloric acid solution with concentration being 1 mol / L, finally, circularly sending the solution into a filling procedure after the solution passes through the fine filter provided with the 0.45 mu m polyether sulfone filter element, putting the solution in a non-PVC co-extrusion infusion bag according to the dosage, setting specific control sterilization parameters in a high-temperature superheated water shower manner during sterilization, and performing lamp inspection and packaging after sterilization to obtain the cimetidine sodium chlorideinjection.

The invention provides a compound florfenicol composition, which comprises the following components in part by weight: 5 to 20 parts of florfenicol or florfenicol pharmaceutically-acceptable salt in an amount which is equal to 5 to 20 parts of florfenicol, 1 to 5 parts of phosphoric acid benproperine and 5 to 10 parts of hydrochloric acid cimetidine. The florfenicol pharmaceutically-acceptable salt is selected from florfenicol sodium succinate and florfenicol sodium phosphate, preferably the florfenicol sodium succinate. The invention also provides application of the compound florfenicol composition to the preparation of a medicine for treating respiratory disease syndromes of pigs. The florfenicol sodium succinate, phosphoric acid benproperine and hydrochloric acid cimetidine are compositely used and are reasonable in proportion; the composition has double efficacy, clinical symptoms caused by respiratory syndromes of pigs can be alleviated quickly, damage of the respiratory diseases to organisms can be reduced, pain of the diseased pigs can be relieved, stress responses of diseased livestock bodies are reduced, and the composition can promote the recovery of organisms and improve immunities.

The invention relates to a taxol and cimetidine pharmaceutical composition, and particularly relates to a combined application package which comprises a taxol injection and a cimetidine-containing injection. When the taxol and cimetidine pharmaceutical composition is in use, cimetidine is subjected to intravenous injection before taxol treatment, and then the taxol is dissolved and diluted by normal saline or a 5% glucose and sodium chloride solution for intravenous drip infusion.

The invention discloses a medicine for treating acne. The medicine is prepared by taking white vinegar and glycerinum as main raw materials, and taking egg white, diphenhydramine, honeysuckle flowers, cimetidine, raw radix astragalis, radix paeoniae rubra and fructus kochiae as auxiliary medicines. Specifically, the medicine comprises the following components in parts by weight: 100-200 parts of white vinegar, 50-100 parts of glycerinum, 5-10 parts of egg white, 15-30 parts of white gourd juice, 5-10 parts of honeysuckle flowers, 2-5 parts of cortex phellodendr, 5-10 parts of raw radix astragalis, 5-10 parts of radix paeoniae rubra, 6-10 parts of fructus kochiae, 0.2-0.3 part of diphenhydramine, 1.6-2.4 parts of cimetidine, 1.6-2.4 parts of chloramphenicol, 0.008-0.012 part of hexadecadrol, 1.6-2.4 parts of metronidazole, and 1.2-1.8 parts of salicylic acid. When used for treating acne, the medicine can reduce sebum secretion of sebaceous gland, inhibit the growth of bacteria inside hair follicles, alleviate inflammatory reaction of skin, and promote absorption and elimination of red and swollen nodules at the hair follicle, so that satisfactory curative effect is achieved in clinic.

Disclosed are a prescription of intravenous medication for blocking a heroin or morphine intoxication path and its using. The prescription of intravenous infusion includes Cerebrolysin, Piracetam, Cimetidine, Scopolamine Butylbromide, Nefopam, B.C Complex, Vitamin B1, Ascorbic Acid, Ketorolac, Guronsan, Hyoscine Butylbromide and Sukerin. The prescription activates a patient's liver and circulatory system to block drug intoxication. The using for blocking drugs includes an acute withdrawal part, wherein the prescription of intravenous infusion is injected and the timing of drug administration and the safe dosage are controlled according to clinical symptoms, and an appropriate amount of a supplementary medicine such as Haloperidol is added, and the processes of detoxication, relieving symptoms, suppressing restlessness, and sobering are conducted to block acute withdrawal symptoms of an acute withdrawal addict quickly and successfully.

The present invention provides to methods and compositions that treat or prevent deleterious effects associated with alcohol consumption including alcohol-induced flush reaction and hangover. The methods and compositions include famotidine and optionally succinic acid. The present invention further demonstrates compositions that include famotidine are effective at treating symptoms associated with a flush reaction in subjects that are not significantly responsive to treatments with the H1 antagonist loratidine or the H2 antagonist cimetidine.

The invention provides a formula of external-use compound wound healing ointment, which is characterized in that the formula comprises the following components: oxytetracycline, berberine, metronidazole, CoVB, VC, cimetidine, Yunnan Baiyao, borneol and vaseline, and the proportion of the components is: 6.7 percent of oxytetracycline, 6.7 percent of berberine, 6.7 percent of Yunnan Baiyao, 3.3 percent of metronidazole, 3.3 percent of cimetidine, 3.3 percent of VC, 2.3 percent of CoVB, 1 percent of borneol, and 66.7 percent of vaseline. The ointment has the advantages that the ointment is good in curative effect and fast in action, solves the problems that other external-use ointments have great limitation in the range and effect of dermatosis treatment and are not ideal in curative effect for the pain, extreme itch and skin rhagadia of some serious anorectal diseases, and is especially suitable for treating anal pruritus, anal fissure, perianal rhagadia, hand-foot rhagadia and other skin diseases.

The invention provides cimetidine composition chewable tablets and a preparation method thereof and relates to the technical field of medicines and medical production. The cimetidine composition chewable tablets comprise cimetidine, starch and cane sugar, the defects of common chewable tablets are overcome by virtue of the tablets disclosed by the invention, the types and amount of auxiliary materials in the cimetidine chewable tablets are reduced, and the pharmaceutical preparation is excellent in performance, high in bioavailability, high in stability and high in patient acceptance, does not have a sense of gravel and has important clinical application value.