6 results about "Cimetidine" patented technology

The utility model discloses vacuum drying equipment for cimetidine dicondensate production, which comprises a bottom frame, the upper surface of the bottom frame is fixedly connected with a rotary transmission device, the rotary transmission device comprises a motor, the output end of the motor is fixedly connected with a first rotating shaft, one end of the first rotating shaft is fixedly connected with a driving belt wheel, and the other end of the first rotating shaft is fixedly connected with a second belt wheel. The outer surface of the driving belt wheel is sleeved with a belt, one end of the belt is sleeved with a driven belt wheel, a second rotating shaft is connected into the driven belt wheel in a penetrating mode, and the two ends of the second rotating shaft are fixedly connected with a second bearing seat and a third bearing seat. A chain wheel is connected to the interior of the second rotating shaft in a penetrating mode, evaporation of water is accelerated by rolling over materials in the rotating cylinder, arranging the heating and drying device and making contact with the hot surface, and by arranging the rotary transmission device, the materials can be evenly heated, caked materials can be scattered, and the drying efficiency is improved.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of cimetidine, in particular to a process for synthesizing cimetidine through continuous flow reaction. According to the process, cyanamide and methyl isocyanate are taken as initial raw materials and are accurately pumped into a microchannel continuous flow reactor according to a certain molar ratio, and the N-cyano-N '-methylurea intermediate is efficiently and controllably synthesized at a specific temperature. And then, synchronously pumping a 2-(((5-methyl-1H-imidazole-4-yl) methyl) sulfo) ethyl-1-amine hydrochloride solution and the N-cyano-N '-methylurea intermediate into a subsequent continuous flow reaction module, introducing the reaction liquid into an online drying device with a molecular sieve in real time, and promoting efficient nucleophilic addition reaction through continuous water removal, thereby obtaining the N-cyano-N'-methylurea intermediate. Finally, the cimetidine is obtained at a high yield. The method has the outstanding advantages of mild conditions, high yield, stable product quality, easiness in large-scale amplification and the like, and is a new generation of cimetidine preparation technology which is green, safe and efficient and has important industrial application value.

The invention belongs to the technical field of organic synthesis. The invention particularly relates to a synthesis method of cimetidine monocondensate and acetate thereof. The method comprises the following steps: taking 1-halogenated butane-2, 3-diketone (compound 1) as a raw material, firstly carrying out substitution reaction with cysteamine and sodium hydroxide to generate 1-((2-aminoethyl) sulfenyl) butane-2, 3-diketone (compound 2), and then carrying out cyclization reaction with hexamethylenetetramine and ammonia gas to generate 2-(((4-methyl-1H-imidazole-5-yl) methyl) sulfenyl) ethylamine (cimetidine monocondensate). And carrying out post-treatment on the cimetidine monocondensate to obtain acetate of the 2-(((4-methyl-1H-imidazole-5-yl) methyl) sulfenyl) ethylamine. The method provided by the invention has the advantages of cheap and easily available materials, mild reaction conditions, high atom economy, relatively less three wastes, environmental friendliness, high product purity, product quality meeting subsequent requirements, and high yield.

This invention relates to the field of viral inhibitor technology, and more particularly to the application of compounds targeting 3CLpro in inhibiting porcine reproductive and respiratory syndrome virus (PRRSV). Using 3CLpro as a target, this invention comprehensively screened various compounds against PRRSV and coronaviruses, discovering that compounds targeting 3CLpro exhibit varying degrees of inhibitory effects on both PRRSV and coronaviruses. In particular, cimetidine, LLY-507, and flupentixol hydrochloride all demonstrate significant anti-PRSV activity. Furthermore, in addition to targeting 3CLpro, LLY-507 and flupentixol hydrochloride may also act on other cellular targets to inhibit PRRSV replication. The three compounds provided by this invention show promising application prospects in the development of anti-PRRSV drugs.

The present invention relates to a pharmaceutical composition for preventing or treating melanoma, comprising cimetidine as an active ingredient, and, more specifically, to a pharmaceutical composition for preventing or treating melanoma, comprising cimetidine and at least one antibody selected from the group consisting of an anti-CTLA-4 antibody and an anti-PD-1 antibody as active ingredients. The present invention can provide a pharmaceutical composition for treating melanoma in which a melanoma treatment effect is increased using cimetidine and an antibody in a combination therapy, and optimized antibody capable of maximizing the melanoma treatment effect during the combination therapy has been identified. In addition, the pharmaceutical composition of the present invention can be specifically applied to melanoma cells to maximize a melanoma treatment effect while minimizing immune-related side effects.

The utility model discloses a trough type mixer convenient for discharging cimetidine tablets, which is characterized in that the upper surface of a trough type mixing barrel is fixedly connected with a stirring motor, the output end of the stirring motor is fixedly connected with a stirring rod, one end of the stirring rod penetrates through a top cover of the trough type mixing barrel and is fixedly connected with a stirring connecting rod, and the other end of the stirring connecting rod is fixedly connected with a stirring motor. A grinding block is fixedly connected to the bottom end of the stirring connecting rod, a grinding plate is fixedly connected to the bottom face of the groove-shaped mixing barrel, a hollowed-out groove is formed in the connecting position of the outer edge of the grinding plate and the inner wall face of the groove-shaped mixing barrel, and two vibration motors are fixedly connected to the bottom face of the groove-shaped mixing barrel; a discharging port is formed in the center of the grinding plate, an electromagnetic valve is fixedly connected to the bottom face of the discharging port, materials are refined and mixed, rapid caking caused by different characteristics of different materials is prevented, the quality of final products is improved, the time of the whole production process is shortened, and the production efficiency is improved.