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675 results about "Diketone" patented technology

A dicarbonyl is a molecule containing two carbonyl (C=O) groups. Their properties often differ from those of monocarbonyls. The simplest are symmetrical dialdehydes, diketones, and diesters. Related to the latter are dicarboxylic acids and diamides. Unsymmetrical dicarbonyls are also prevalent, e.g. keto-aldehydes, keto acids, etc.

Rare earth organic-inorganic hybrid complex scintillator and preparation method and application thereof

The invention relates to the technical field of scintillator materials and X-ray detection, in particular to a rare earth organic-inorganic hybrid complex scintillator and a preparation method and application thereof. The general formula of the rare earth organic-inorganic hybrid complex scintillator is [RE (L) 4] <->. [A] < + >, wherein RE is selected from Eu, Tb, Sm or Dy; l is a beta-diketone ligand; [A] < + > is selected from long-chain hydrophobic quaternary ammonium salt cations or heterocyclic quaternary ammonium cations which have the carbon atom number of C8-C20 and do not contain active functional groups. The rare earth organic-inorganic hybrid complex scintillator provided by the invention has good solubility and molecular-level dispersion capability. The scintillator film based on the rare earth organic-inorganic hybrid complex prepared by using the rare earth organic-inorganic hybrid complex has the characteristic of compatibility of high scintillator load and high light transmission, overcomes the problems of low scintillator load rate, poor transparency and limited imaging resolution of the traditional scintillator film, and has excellent practical value and popularization prospect.
Owner:JINGGANGSHAN UNIVERSITY

Strain for degrading aspartame, algal-bacterial symbiotic system and application of algal-bacterial symbiotic system

The invention discloses a bacterial strain for degrading aspartame, a bacterial-algae symbiotic system and application of the bacterial strain and the bacterial-algae symbiotic system, the bacterial strain is corn sphingomonas zeae NCU J1, and the preservation number of the bacterial strain is CCTCC (China Center for Type Culture Collection) NO: M 20251462. And an algal-bacterial symbiotic system is constructed by adopting an oriented symbiotic combination of the corn sphingomonas NCU J1 and the chlorella sp. The corn sphingomonas NCU J1 can metabolize an artificial sweetening agent aspartame and degradation products thereof, metabolism complementation can be achieved through an algal-bacterial symbiotic interface, and bacteria preferentially promote aspartame to be subjected to photohydrolysis to generate degradation products such as diketopiperazine derivatives. The microalgae synchronously start isomerism enzymatic reaction to convert degradation products such as diketopiperazine derivatives into low-toxicity products, the risk of secondary pollution is reduced by 40% or above compared with that of a traditional physical and chemical method, 150 mg / L aspartame can be efficiently degraded within 2 days, generation of derivatives of aspartame can be greatly reduced, secondary pollution is reduced, and the method is suitable for industrial production. And the method has a good application prospect in the aspect of rapidly treating aspartame-containing wastewater.
Owner:NANCHANG UNIV

Process for preparing 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

ActiveUS12441729B2Organic chemistryHybrid compoundAcyl group
Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes
Owner:AMGEN INC

Synthetic method of ornamental blue

PendingCN120383558AOrganic chemistryAzo dyesDiketoneChemical condensation
The invention relates to the technical field of pigment synthesis, and particularly discloses a synthetic method of ornamental blue. According to the synthetic method, 5-hydroxy-3-iminopyridine-2, 6-diketone is adopted as a raw material, enol interconversion is performed on the raw material under the alkaline condition (under the action of an alkali catalyst), heating is performed, and chemical condensation reaction is performed to obtain the ornamental blue. The synthetic method of the ornamental blue provided by the invention is simple in process and high in reaction selectivity, the yield and purity of the product are high, the yield of the ornamental blue product is more than or equal to 80%, the purity of the ornamental blue product is more than 99%, the synthetic method has obvious advantages, no potential safety hazard exists in the process, and industrial production can be realized.
Owner:VERTEXYN (NANJING) BIOWORKS CO LTD

HPVC power cable protection pipe and preparation method thereof

The invention discloses an HPVC power cable protection pipe and a preparation method thereof, and relates to the technical field of cable protection pipes. The HPVC power cable protection tube is at least prepared from the following raw materials in parts by weight: 100 parts of high-strength polyvinyl chloride, 35 to 45 parts of epoxy acrylate rubber, 5 to 8 parts of vinyl chloride-g-acrylate copolymer, 8 to 12 parts of epoxidized soybean oil, 3 to 5 parts of calcium-zinc composite stabilizer, 5 to 15 parts of modified hydrotalcite, 0.1 to 0.5 part of beta-diketone, 0.8 to 1.5 parts of calcium stearate and 10 to 20 parts of flame retardant. 12 to 15 parts of modified nano calcium carbonate, 5 to 8 parts of talcum powder, 0.6 to 1.2 parts of antioxidant, 1 to 2 parts of anti-aging agent 4010 and 0.5 to 1.5 parts of ultraviolet light absorber UV531; the modified hydrotalcite is obtained by adding a mixed solution of calcium nitrate and lanthanum nitrate, a sodium hydroxide solution and a sodium bicarbonate solution into a lauryl sodium sulfate solution, mixing and aging, and then carrying out a post-treatment process. The HPVC power cable protection tube prepared by the invention has relatively high strength, good mechanical properties, weather resistance and cold resistance, and long service life.
Owner:FUYANG BAINUO PIPE CO LTD

Preparation method of 5-hydroxy-3-iminopyridine-2, 6-diketone

The invention discloses a preparation method of 5-hydroxy-3-iminopyridine-2, 6-diketone, and relates to the technical field of compound preparation. The invention provides a preparation method of 5-hydroxy-3-iminopyridine-2, 6-diketone, which comprises the following steps: uniformly mixing observation blue with at least one oxidant of sodium hypochlorite, potassium permanganate and hydrogen peroxide according to a molar ratio of 1: (0.5-1.5) under a solution condition, reacting for 5-120 minutes, and adding a reducing agent to finish the reaction, thereby obtaining a target product. According to the preparation method provided by the invention, on the basis of the amide structure of the ornamental blue, 'endogenous catalysis' of the reaction can be realized, no additional catalyst needs to be introduced, and the 5-hydroxy-3-iminopyridine-2, 6-diketone with the yield of more than 60.53% and the purity of more than 60.2% can be prepared through a simple and convenient one-step reaction.
Owner:XUZHOU HEGU LIFE TECH CO LTD

Iridium-containing metal heterocyclic phosphorescent doped material and organic electroluminescent device

The invention belongs to the technical field of organic electroluminescent materials, and provides an iridium-containing heterocyclic phosphorescent doping material and an organic electroluminescent device.The doping material has a compound general formula shown in the formula I. Quinoline and a naphthalene ring are connected through silane or germane, and a silicon or germanium six-membered heterocyclic structure is formed. And reacting with iridium metal and a diketone monomer to obtain the iridium metal heterocyclic phosphorescent organic light-emitting material. The heteroatom silicon or germanium in the material can adjust molecular orbital HOMO and LUMO energy levels, and the polarity effect of heteroatoms promotes electron migration, reduces interface potential barriers and electron injection barriers, reduces carrier injection loss and improves carrier mobility, so that driving voltage is reduced, and the external quantum efficiency of a device is improved. In addition, the silicon or germanium heterocyclic ring has better rigidity, so that the overall stability of the structure is enhanced, and the rigid structure can prolong the service life of the device.
Owner:JILIN OPTICAL & ELECTRONICS MATERIALS CO LTD

Heat insulation type ionic intermediate film and preparation method thereof

The invention relates to the technical field of intermediate membranes, in particular to a heat insulation type ionic intermediate membrane and a preparation method thereof.The heat insulation type ionic intermediate membrane is characterized in that hollow silicon dioxide nanotubes serve as filler, epoxy resin modified polyurethane emulsion serves as a base material, auxiliaries are added to prepare a heat insulation coating, and the ionic intermediate membrane layer is coated with the heat insulation coating to form a heat insulation layer; the preparation method comprises the following steps: carrying out amination on a hollow silicon dioxide nanotube by using 3-aminopropyltriethoxysilane, carrying out dehydration condensation on furan-2, 5-diketone and an amino group to synthesize maleimide so as to obtain a maleimide modified hollow silicon dioxide nanotube, and grafting furan carboxylic acid imidazolium salt polyionic liquid by using a Diels-Alder reaction so as to obtain a composite hollow silicon dioxide nanotube; aminated glass fibers, composite hollow silicon dioxide nanotubes, epoxy resin modified polyurethane emulsion and auxiliaries are mixed, and a reinforcing layer coating is obtained; and coating the lower surface of the ionic intermediate film layer with a reinforcing layer coating to form the reinforcing layer.
Owner:DONGGUAN QUNAN PLASTIC IND CO LTD

Thienopyrimidine derivative

The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl) thieno[2,3-d]pyrimidine-2,4 (1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.
Owner:TAKEDA PHARMA CO LTD

Novel method for synthesizing 1, 3-diketone organic matter

The invention discloses a novel method for synthesizing 1, 3-diketone organic matters, which comprises the following steps: by taking acyl chloride and silyl enol ether as raw materials, generating acyl free radicals through photo-induced copper catalysis, and carrying out free radical addition reaction on the acyl free radicals and silyl enol ether, thereby efficiently constructing 1, 3-diketone compounds. Compared with strong base, oxidant, high temperature and expensive metal catalyst required by the existing method, the method provided by the invention adopts the cheap and high-yield copper catalyst, so that the production cost is reduced, and the economic benefit is improved. In addition, the method has mild reaction conditions, easily available catalysts and raw materials, utilizes clean and sustainable light energy as driving force, is simple and convenient to operate, and is suitable for large-scale production. The invention provides an economic and environment-friendly innovative way for synthesizing the 1, 3-diketone compound, and has a wide application prospect.
Owner:GUANGXI UNIV

Quinoid structure-based non-condensed ring small molecule acceptor material as well as preparation method and application thereof

The invention relates to the technical field of organic photoelectric materials, and particularly discloses a non-condensed ring small molecule acceptor material based on a quinonoid structure as well as a preparation method and application of the non-condensed ring small molecule acceptor material. According to the invention, easily available 1, 4-diacetyl piperazine-2, 5-diketone is used as a center, an alkyl chain and Ar are used for modification, EG is used as an end group, the non-condensed ring A-D-A '-D-A type structure acceptor material based on a quinone structure is constructed, and the general formula is shown in the specification. Wherein the PCE of the acceptor material which is modified by bithiophene and takes 2-(3-ethyl-4-oxothiazolidine-2-subunit) malononitrile as a terminal group reaches 15%. The non-condensed ring small molecule acceptor material based on the quinonoid structure is simple in synthesis process, and an effective strategy is provided for solving the problem of the overall performance of an organic solar cell.
Owner:JIANGHAN UNIVERSITY

Preparation and application method of porous microsphere adsorbent for extracting lithium

The invention relates to the technical field of lithium adsorbents, in particular to a preparation and application method of a porous microsphere adsorbent for extracting lithium, and the preparation method comprises the following steps: preparing a water phase solution containing methacrylic acid, water and an emulsifier; the preparation method comprises the following steps: preparing an oil phase solution containing a fluorinated methacrylate monomer containing beta-diketone, cyclohexyl methacrylate, methoxyethyl methacrylate, N, N-bis (acryloyl) cystamine, ethylene glycol dimethacrylate, azodiisobutyronitrile and a solvent; dropwise adding the oil-phase solution into the water-phase solution for gradient emulsification, adding sodium persulfate to initiate polymerization, and performing centrifugal drying to obtain porous microspheres; and immersing the porous microspheres into a NaOH solution for hydrolysis activation, and drying to obtain the porous microsphere adsorbent for selective adsorption of lithium ions. Wherein the beta-diketone can enhance the targeted adsorption effect of the adsorbent on lithium ions and has relatively high selectivity and adsorption capacity, and the strong electron-withdrawing property of CF3 further polarizes carbonyl and enhances the coordination ability of the lithium ions.
Owner:常州中源技术股份有限公司

Compound calcium-zinc stabilizer as well as preparation method and application thereof

The invention discloses a compound calcium-zinc stabilizer as well as a preparation method and application thereof, and relates to the field of calcium-zinc stabilizers. The calcium-zinc stabilizer comprises calcium stearate, zinc stearate, phosphite ester, an epoxy compound, lanthanum oxide, beta-diketone, a lubricant, an antioxidant and a filler. Uniformly mixing calcium stearate, zinc stearate and lanthanum oxide; adding phosphite ester, an epoxy compound and beta-diketone, and uniformly mixing; and adding the lubricant, the antioxidant and the filler, and uniformly mixing. The calcium-zinc stabilizer is applied to the field of PVC films. By adding calcium / zinc stearate as a main stabilizer and adding lanthanum oxide to be compounded with the main stabilizer, the thermal stability of the PVC film is further improved, and the initial whiteness and light transmittance of the PVC film are obviously improved compared with those of the PVC film in which lanthanum oxide is not added.
Owner:ANHUI HUAWEN PLASTIC TECH CO LTD

Liquid sulfur removal agent and preparation method thereof

The invention provides a liquid sulfur removal agent and a preparation method thereof, and belongs to the technical field of natural gas hydrogen sulfide removal treatment.The liquid sulfur removal agent comprises, by weight, 36-66% of s-triazine derivatives, 5-8% of sulfolane, 2-5% of a pH control agent, 10-12% of a stabilizer, 5-8% of a scale inhibitor, 1-2% of a bactericide and the balance deionized water; wherein the s-triazine derivative is selected from a mixture of hexahydro-1, 3, 5-triacetyl-hexahydros-triazine, 1, 3, 5-triacetyl-hexahydros-triazine and 1, 3, 5-triazinane-2, 4-diketone, and the structural formula of the s-triazine derivative is shown in the description. The liquid sulfur removal agent is high in sulfur removal efficiency, good in corrosion inhibition and sterilization performance and not prone to scaling.
Owner:CHINA PETROLEUM ENG & CONSTR +1

Application of small molecule compound in preparation of product for preventing and / or treating pulmonary arterial hypertension and complications thereof

PendingCN120437133ARespiratory disorderCardiovascular disorderArterial smooth muscle cellsSmall artery
The invention belongs to the technical field of medicines, and discloses an application of a small molecule compound in preparation of a product for preventing and / or treating pulmonary arterial hypertension and complications thereof. The small molecule compound is 8-[[4-(cyclopropanecarbonyl) piperazine-1-yl] methyl]-1, 3-dimethyl-7-(3-methylbutyl) purine-2, 6-diketone, and the structural formula is as shown in a formula (I): # imgabs0. The small molecule compound and pharmaceutically acceptable salts thereof have a remarkable treatment effect on pulmonary arterial hypertension and complications thereof, and can be used for treating pulmonary arterial hypertension and complications thereof. The effects of preventing and / or treating the pulmonary arterial hypertension include the reduction of right heart hypertrophy, the reduction of right ventricular systolic pressure, right heart enlargement, right heart dysfunction, pulmonary vascular remodeling, pulmonary arterial intima thickness, increase of vascular myelization, pulmonary arterial smooth muscle cell proliferation and migration, the reduction of the right ventricular hypertrophy, the reduction of the right ventricular hypertrophy, the reduction of the right ventricular hypertrophy and the reduction of the right ventricular hypertrophy. The pulmonary arterial intima thickness and the vascular myelization level are improved, pulmonary vascular remodeling is reversed, and pulmonary artery smooth muscle cell proliferation and migration are inhibited.
Owner:HENAN UNIV HUAIHE HOSPITAL

Diketone biphenyl compound serving as VAV1 degradation agent and application of diketone biphenyl compound

The invention provides a diketone biphenyl compound serving as a VAV1 degradation agent and application of the diketone biphenyl compound. Specifically provided are a compound represented by formula (I), a tautomer, a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof. The compound provided by the invention is good in drug effect and can be used for preparing drugs for treating or preventing VAV1 related diseases.
Owner:HUBEI BIO PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE INC

Low-temperature cured polyurethane varnish resin for automobiles and preparation method of low-temperature cured polyurethane varnish resin

The invention discloses a low-temperature cured polyurethane varnish resin for automobiles and a preparation method thereof, and belongs to the technical field of chemical product processing, the low-temperature cured polyurethane varnish resin comprises a resin matrix and a curing agent, the resin matrix comprises a component A and a component B. The component A comprises a crosslinking system A1, a crosslinking system A2 and an auxiliary agent, the component B is a curing activity regulator of a double-crosslinking system of the crosslinking system A1 and the crosslinking system A2; the curing agent is diethyl malonate blocked isocyanate; the cross-linking system A1 is mainly composed of hydroxy acrylic resin containing beta-diketone metal ligand and a bismuth neodecanoate catalyst; the bismuth neodecanoate catalyst and a beta-diketone metal ligand form a bismuth complex; the cross-linking system A2 is mainly composed of hydroxyl acrylic resin containing alkoxy silane groups; the component B is prepared from poly (decane-4, 6-diyne diacid) modified nano porous fibers and a silane coupling agent. The service life of the varnish is prolonged on the basis of ensuring low-temperature rapid curing.
Owner:HUATU CHEM (JILIN) CO LTD

Fluorescent probe for detecting hypochlorous acid as well as preparation method and application of fluorescent probe

The invention relates to a fluorescent probe for hypochlorous acid detection and a preparation method and application thereof, the chemical name of the fluorescent probe for hypochlorous acid detection is 5-butyl-10, 10-difluoro-9-(4-(methylthio) phenyl)-5-hydro-4H, 10H-9 lambda 4, 10 lambda 4-benzo [de] [1, 3, 2] oxazaboraza [6, 5-g] isoquinoline-4, 6-diketone, and the structural formula of the fluorescent probe for hypochlorous acid detection is as shown in the following formula I. The invention further discloses a preparation method of the fluorescent probe for hypochlorous acid detection. According to the fluorescent probe for hypochlorous acid detection, N-butyl-3-aldehyde-4-hydroxy-1, 8-naphthalimide and (E)-2-butyl-6-hydroxy-5-(((4-(methylthio) phenyl) imino) methyl)-1H-benzo [de] isoquinoline-1, 3 (2H)-diketone are used as raw materials, and the fluorescent probe can be used for detecting hypochlorous acid. Compared with the prior art, the fluorescent probe for hypochlorous acid detection is simple and convenient in synthesis method, simple and easily available in raw materials, good in hypochlorous acid selectivity, relatively high in sensitivity and large in Stokes shift, and has a very good application prospect in hypochlorous acid detection.
Owner:SHANGHAI BAIAOXIN TECHNOLOGY CO LTD

3-ketosteroid-delta1-dehydrogenase mutant and application thereof in catalyzing dehydrogenation of steroid compound

The invention discloses a 3-ketosteroid-delta1-dehydrogenase mutant and application of the 3-ketosteroid-delta1-dehydrogenase mutant in catalyzing dehydrogenation of a steroid compound, the mutant with high catalytic activity is obtained through screening, and the solubility of a substrate is increased by adding a cosolvent Tween-80, so that the biological catalytic efficiency is improved. Under the optimal condition, the mutant disclosed by the invention can improve the feeding amount conversion rate of 15g / L of (16 alpha)-methyl androstane-4, 9-diene-3, 17-diketone to 99.9%.
Owner:ZHEJIANG UNIV OF TECH

Curcumin / dihydrocurcumin reductase MaCurA, coding gene and application

The invention belongs to the technical field of biological engineering, and provides curcumin / dihydrocurcumin reductase MaCurA, a coding gene and application. The reductase can efficiently catalyze 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-diketone to synthesize tetrahydrocurcumin, an efficient solution is provided for industrial preparation of tetrahydrocurcumin, and experiments prove that the recombinase can catalyze the synthesis of tetrahydrocurcumin in the catalysis of 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-diketone. In a reaction system for preparing tetrahydrocurcumin from 2, 5-diketone, actually measured enzyme activity is stabilized at 3.38 U / mg level, and compared with a traditional chemical synthesis method, the production efficiency is remarkably improved.
Owner:SHANDONG UNIV OF TECH

Piperidine diketone compound, and pharmaceutical composition and application thereof

PendingCN121673261AOrganic active ingredientsNervous disorderDiseasePiperidinedione
The invention relates to a piperidinedione compound as well as a pharmaceutical composition and application thereof, and particularly provides a piperidinedione compound shown in a formula (I) which can be used for preparing medicines, especially medicines for preventing and / or treating diseases or symptoms caused by or related to lymphocyte development or activity disorder. Each group in the formula (I) is as defined in the specification.
Owner:SHANGHAI MEIYUE BOITECH DEVELOPMENT CO LTD

Compound extracting agent for lithium-containing solution and method for extracting lithium in solution

The invention relates to a compound extraction agent of a lithium-containing solution and an extraction method of lithium in the solution, in particular to the field of lithium resource utilization, and the compound extraction agent comprises a neutral phosphine extraction agent, a phenolic ketone extraction agent and a beta-diketone extraction agent in a volume ratio of (3-5): 1: (1-5). According to the compound extracting agent provided by the invention, efficient extraction of the lithium element in a solution is realized through the synergistic effect of the extracting agents, the utilization effect of lithium is ensured, the extraction rate of lithium is greater than or equal to 99%, and the reverse extraction rate of lithium is greater than or equal to 99%.
Owner:INSTITUTE OF PROCESS ENGINEERING CHINESE ACADEMY OF SCIENCES

Preparation method of 11 beta, 17 alpha-dihydroxy-6 alpha-methylpregna-4-ene-3, 20-diketone

The invention relates to the technical field of pharmaceutical chemicals, in particular to a preparation method of 11beta, 17alpha-dyhydroxyl-6 alpha-methylpregna-4-ene-3, 20-diketone, and discloses a preparation method of 11beta, 17alpha-dyhydroxyl-6 alpha-methylpregna-4-ene-3, 20-diketone. The method comprises the following steps: S1, adding a 11beta, 17alpha-dyhydroxyl-6 alpha-methylpregna-4-ene-3, 20-diketone crude product into a mixed solution of a solvent A and a solvent B, heating to 25-35 DEG C, and stirring for dissolving until the solution is clear, so as to obtain a 11beta, 17alpha-dyhydroxyl-6 alpha-methylpregna-4-ene-3, 20-diketone crude product; s2, carrying out transposition elimination reaction; s3, carrying out acidification deprotection reaction; s4, adjusting the pH value; s5, standing and layering; s6, decoloring; s7, performing concentration; s8, cooling and crystallizing; s9, carrying out solid-liquid separation; and S10, carrying out vacuum drying, so as to obtain a finished product of the 11beta, 17alpha-dyhydroxyl-6 alpha-methyl pregna-4-ene-3, 20-diketone. The method has the characteristics of high yield and good product quality, is stable and is easy to realize industrial production.
Owner:SHANDONG SIRUI BIOPHARMACEUTICAL CO LTD +1

Method for synthesizing 1, 4-diketone by photooxidation reduction catalysis of alkenyl amide and alpha-carbonyl oxidation sulfonium ylide

The invention relates to the fields of medicine, organic chemical industry and fine chemical industry, in particular to a method for synthesizing 1, 4-diketone by catalyzing alkenyl amide and alpha-carbonyl oxidized sulfonium ylide through photooxidation reduction. The preparation method comprises the following steps: under the protection of inert gas, reacting alkenyl amide and alpha-carbonyl oxidized sulfonium ylide serving as substrates in an organic solvent by taking a photosensitizer as a catalyst under the action of blue light irradiation and alkali at 30 DEG C for 18 hours to obtain an alkenyl amide alpha-carbonyl alkylate, and then hydrolyzing under an acidic condition to synthesize various asymmetric 1, 4-diketone compounds. The 1, 4-diketone compound is synthesized by a two-step method by taking alkenyl amide and alpha-carbonyl oxidized sulfonium ylide as initial raw materials, and the method has the remarkable advantages of wide substrate raw material sources, simplicity and convenience in operation, mild reaction conditions, high reaction efficiency, good universality, excellent functional group compatibility and the like.
Owner:CHANGZHOU UNIV

Preparation method and application of 3-aryl piperidine-2, 6-diketone VAV1 molecular glue degradation agent

The invention discloses a 3-aryl piperidine-2, 6-diketone compound as shown in a general formula I or an enantiomer, a diastereoisomer, a raceme and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the 3-aryl piperidine-2, 6-diketone compound, the compound is used as a VAV1 targeted molecular glue degradation agent, and can degrade VAV1 protein in a targeted manner, so that the VAV1 protein can be degraded in a targeted manner. The invention has the application of preparing medicines for treating and / or preventing inflammatory diseases and autoimmune diseases.
Owner:CHINA PHARM UNIV

Resist composition and patterning process

A resist composition comprising a base polymer and a quencher is provided. The quencher is a salt compound consisting of a cyclic ammonium cation and an anion derived from a fluorinated 1,3-diketone compound, fluorinated β-keto ester compound or fluorinated imide compound. The resist composition has a high sensitivity and forms a pattern with improved LWR or CDU, independent of whether it is of positive or negative tone.
Owner:SHIN ETSU CHEMICAL CO LTD

8, 8-difluoro-2-oxaspiro [4, 5] decane-1, 3-diketone compound as well as preparation method and application thereof

PendingCN120504652ABiocideOrganic chemistryOrder LepidopteraSpirodecane
The invention relates to the technical field of spiro compounds, in particular to an 8, 8-difluoro-2-oxaspiro [4, 5] decane-1, 3-diketone compound as well as a preparation method and application thereof. The invention provides the 8, 8-difluoro-2-oxaspiro [4, 5] decane-1, 3-diketone compound, the compound shows excellent biological activity, and through test comparison, when the mass concentration is 0.1 mu g / mL, the insecticidal effect of the compound is increased by nearly 10% compared with that of a common insecticide chlorantraniliprole. It means that the compound shows a more efficient insecticidal effect on lepidoptera pests such as plutella xylostella and the like under a lower dosage, and cost reduction and synergism are realized. Due to the characteristic, the compound or the agronomically acceptable salt thereof shows important potential application value in the field of insecticides, and a new thought is provided for upgrading and updating of insecticides in the future.
Owner:GUANGDONG POLYTECHNIC OF ENVIRONMENTAL PROTECTION ENG

Fused polycyclic substituted 5-carboxylic acid thienopyrimidinedione compounds and uses thereof

The present invention discloses a series of fused polycyclic substituted 5-carboxylic acid thienopyrimidinedione compounds and their uses, specifically, those of formula (II): The compound represented by TIFF2024507408000065.tif5475 and pharma- ceutically acceptable salts thereof are disclosed.
Owner:CMS RESEARCH & DEVELOPMENT PTE LTD

Anthraquinone compound with anti-MTV activity as well as preparation method and application of anthraquinone compound

The invention discloses an anthraquinone compound with anti-MTV activity and a preparation method and application thereof.The anthraquinone compound with the anti-MTV activity is prepared from stems and leaves of desmodium caudatum through the steps of pretreatment, extract extraction, silica gel column chromatography and separation and purification, the molecular formula of the anthraquinone compound with the anti-MTV activity is C18H17O7, and the structural formula of the anthraquinone compound with the anti-MTV activity is shown in the description. The preparation method comprises the following steps: 1, 6-dihydroxy-2, 7, 8-trimethoxy-3-methyl anthracene-9, 10-diketone is used as a raw material, and is named as 1, 6-dihydroxy-2, 7, 8-trimethoxy-3-methyl According to the invention, the English name is 1, 6-dihydroxy-2, 7, 8-trimesoxy-3-methylanthracene-9, 10-dione, and the English name is 1, 6-dihydroxy-2, 7, 8-trimesoxy-3-methylanthracene-9, 10-dione. The present invention has the following structure. Activity tests show that the compound has a certain inhibition effect on MTV. The novel compound disclosed by the invention is novel in structure, has certain anti-MTV activity, can be used as an anti-MTV lead compound, and can be used for research and development of anti-MTV prevention and treatment drugs.
Owner:YUNNAN MINZU UNIV