959 results about "Diketone" patented technology

The invention relates to the technical field of scintillator materials and X-ray detection, in particular to a rare earth organic-inorganic hybrid complex scintillator and a preparation method and application thereof. The general formula of the rare earth organic-inorganic hybrid complex scintillator is [RE (L) 4] <->. [A] < + >, wherein RE is selected from Eu, Tb, Sm or Dy; l is a beta-diketone ligand; [A] < + > is selected from long-chain hydrophobic quaternary ammonium salt cations or heterocyclic quaternary ammonium cations which have the carbon atom number of C8-C20 and do not contain active functional groups. The rare earth organic-inorganic hybrid complex scintillator provided by the invention has good solubility and molecular-level dispersion capability. The scintillator film based on the rare earth organic-inorganic hybrid complex prepared by using the rare earth organic-inorganic hybrid complex has the characteristic of compatibility of high scintillator load and high light transmission, overcomes the problems of low scintillator load rate, poor transparency and limited imaging resolution of the traditional scintillator film, and has excellent practical value and popularization prospect.

The invention provides a synthesis method of 6-(t-butyloxycarboryl)-3, 6-diazabicyclo [3.1. 1] heptane, which comprises the following steps: starting from N-benzyl-2, 6-piperidinedione, firstly forming a dibromide 1, then forming a bridge ring intermediate 2 under alkaline conditions, then removing benzyl to obtain an intermediate 3, then reducing dicarbonyl to form free amine 4, and finally synthesizing the 6-(t-butyloxycarboryl)-3, 6-diazabicyclo [3.1. 1] heptane. Then performing Boc protection on amino to obtain an intermediate 5, and performing debenzylation to form a target product. According to the synthesis method, few impurities are generated, and the product is easy to purify and high in purity, so that the total yield is increased, the unit cost is effectively reduced, and large-scale industrial production is facilitated.

The invention discloses a bacterial strain for degrading aspartame, a bacterial-algae symbiotic system and application of the bacterial strain and the bacterial-algae symbiotic system, the bacterial strain is corn sphingomonas zeae NCU J1, and the preservation number of the bacterial strain is CCTCC (China Center for Type Culture Collection) NO: M 20251462. And an algal-bacterial symbiotic system is constructed by adopting an oriented symbiotic combination of the corn sphingomonas NCU J1 and the chlorella sp. The corn sphingomonas NCU J1 can metabolize an artificial sweetening agent aspartame and degradation products thereof, metabolism complementation can be achieved through an algal-bacterial symbiotic interface, and bacteria preferentially promote aspartame to be subjected to photohydrolysis to generate degradation products such as diketopiperazine derivatives. The microalgae synchronously start isomerism enzymatic reaction to convert degradation products such as diketopiperazine derivatives into low-toxicity products, the risk of secondary pollution is reduced by 40% or above compared with that of a traditional physical and chemical method, 150 mg / L aspartame can be efficiently degraded within 2 days, generation of derivatives of aspartame can be greatly reduced, secondary pollution is reduced, and the method is suitable for industrial production. And the method has a good application prospect in the aspect of rapidly treating aspartame-containing wastewater.

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

The invention relates to the technical field of pigment synthesis, and particularly discloses a synthetic method of ornamental blue. According to the synthetic method, 5-hydroxy-3-iminopyridine-2, 6-diketone is adopted as a raw material, enol interconversion is performed on the raw material under the alkaline condition (under the action of an alkali catalyst), heating is performed, and chemical condensation reaction is performed to obtain the ornamental blue. The synthetic method of the ornamental blue provided by the invention is simple in process and high in reaction selectivity, the yield and purity of the product are high, the yield of the ornamental blue product is more than or equal to 80%, the purity of the ornamental blue product is more than 99%, the synthetic method has obvious advantages, no potential safety hazard exists in the process, and industrial production can be realized.

Photoswitchable photoinitiators comprising a photochromic molecule including one or more substituents at least one of which comprises a substituted or unsubstituted alpha-diketone moiety represented by general formula Ar1—C(═O)—C(═O)—Ar2, wherein Ar1 and Ar2 are the same or different and are independently a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group. Preferably the photochromic molecule comprises a benzospiropyran molecule, a naphthopyran molecule, or a spironaphthoxazine molecule. Photohardenable compositions, hardenable resin compositions, and methods for forming an object, which photohardenable compositions, hardenable resin compositions, and methods include a photoswitchable photoinitiator described herein, are also disclosed.

The invention discloses an HPVC power cable protection pipe and a preparation method thereof, and relates to the technical field of cable protection pipes. The HPVC power cable protection tube is at least prepared from the following raw materials in parts by weight: 100 parts of high-strength polyvinyl chloride, 35 to 45 parts of epoxy acrylate rubber, 5 to 8 parts of vinyl chloride-g-acrylate copolymer, 8 to 12 parts of epoxidized soybean oil, 3 to 5 parts of calcium-zinc composite stabilizer, 5 to 15 parts of modified hydrotalcite, 0.1 to 0.5 part of beta-diketone, 0.8 to 1.5 parts of calcium stearate and 10 to 20 parts of flame retardant. 12 to 15 parts of modified nano calcium carbonate, 5 to 8 parts of talcum powder, 0.6 to 1.2 parts of antioxidant, 1 to 2 parts of anti-aging agent 4010 and 0.5 to 1.5 parts of ultraviolet light absorber UV531; the modified hydrotalcite is obtained by adding a mixed solution of calcium nitrate and lanthanum nitrate, a sodium hydroxide solution and a sodium bicarbonate solution into a lauryl sodium sulfate solution, mixing and aging, and then carrying out a post-treatment process. The HPVC power cable protection tube prepared by the invention has relatively high strength, good mechanical properties, weather resistance and cold resistance, and long service life.

The invention discloses a preparation method of 5-hydroxy-3-iminopyridine-2, 6-diketone, and relates to the technical field of compound preparation. The invention provides a preparation method of 5-hydroxy-3-iminopyridine-2, 6-diketone, which comprises the following steps: uniformly mixing observation blue with at least one oxidant of sodium hypochlorite, potassium permanganate and hydrogen peroxide according to a molar ratio of 1: (0.5-1.5) under a solution condition, reacting for 5-120 minutes, and adding a reducing agent to finish the reaction, thereby obtaining a target product. According to the preparation method provided by the invention, on the basis of the amide structure of the ornamental blue, 'endogenous catalysis' of the reaction can be realized, no additional catalyst needs to be introduced, and the 5-hydroxy-3-iminopyridine-2, 6-diketone with the yield of more than 60.53% and the purity of more than 60.2% can be prepared through a simple and convenient one-step reaction.

The invention belongs to the technical field of organic electroluminescent materials, and provides an iridium-containing heterocyclic phosphorescent doping material and an organic electroluminescent device.The doping material has a compound general formula shown in the formula I. Quinoline and a naphthalene ring are connected through silane or germane, and a silicon or germanium six-membered heterocyclic structure is formed. And reacting with iridium metal and a diketone monomer to obtain the iridium metal heterocyclic phosphorescent organic light-emitting material. The heteroatom silicon or germanium in the material can adjust molecular orbital HOMO and LUMO energy levels, and the polarity effect of heteroatoms promotes electron migration, reduces interface potential barriers and electron injection barriers, reduces carrier injection loss and improves carrier mobility, so that driving voltage is reduced, and the external quantum efficiency of a device is improved. In addition, the silicon or germanium heterocyclic ring has better rigidity, so that the overall stability of the structure is enhanced, and the rigid structure can prolong the service life of the device.

Curable compositions comprise at least one (meth)acrylate monomer; silver; and a photoinitiator system. The photoinitiator system comprises at least one cyclic β-diketone represented by the formula (I) or a tautomer thereof, wherein: R1 represents H or an organic moiety having from 1 to 32 carbon atoms and optionally 1 to 12 heteroatoms selected from O, N, and combinations thereof; each R2 independently represents H or an aliphatic group having from 1 to 12 carbon atoms, and up to two of oxygen and sulfur atoms; and n represents 1, 2, or 3; and at least one Type II photoinitiator. Methods of making and using the compositions are also disclosed.

The invention belongs to the field of conducting polymers, and discloses a method for synthesizing an n-type conducting polymer poly (benzodifuran diketone) (PBFDO). The method comprises the following steps: in an inert atmosphere, dispersing benzodifuran diketone (BFDO), S8 and organic alkali in an organic solvent, then carrying out a heating reaction, and after the reaction is finished, pouring into a dialysis bag for dialysis to obtain the n-type conductive polymer PBFDO. The conductivity of the prepared n-type conductive polymer poly (benzodifuran diketone) (PBFDO) is as high as 2300 S cm <-1 >.

The invention relates to the technical field of desulfurization and decarburization agents, and particularly discloses a preparation method of a desulfurization and decarburization agent. The invention relates to a preparation method of a desulfurization and decarburization agent, which comprises the following steps of: polymerizing 3, 3-dimethyl quinoline-2, 4 (1H, 3H)-diketone and triptycene serving as monomers through a hydroxyalkylation reaction under an acidic condition to obtain an amorphous multi-nanopore polymer 1, and then performing Hofmann alkylation reaction on iodoethane and amino for ionization to obtain the desulfurization and decarburization agent. Finally, the desulfurization and decarbonization agent is obtained through anion exchange with sodium hydroxide, and the obtained desulfurization and decarbonization agent has the advantages of being excellent in sulfur dioxide selectivity, high in sulfur dioxide removal rate and good in carbon dioxide co-adsorption rate and regeneration performance.

The invention discloses a method for extracting a p-phenylenediamine antioxidant in a liquid sample and application of the p-phenylenediamine antioxidant. The p-phenylenediamine antioxidant comprises N-(1, 2, 4-trimethyl-1, 3-pentanediol) the organic solvent is at least one of N, N '-diphenyl-1, 3-dimethyl butyl)-N'-phenyl p-phenylenediamine, N-cyclohexyl-N '-phenyl p-phenylenediamine, N-isopropyl-N'-phenyl-p-phenylenediamine, N, N '-diphenyl-1, 4-phenylenediamine, N, N'-di-2-naphthyl p-phenylenediamine and 2-((4-methylpentane-2-yl) amino)-5-(phenyl amino) cyclohex-2, 5-diene-1, 4-diketone. According to the method, liquid-liquid extraction which is simple and efficient to operate, low in cost and good in repeatability is adopted as a sample pretreatment method, and is combined with an isotope label method and an ultra-high performance liquid chromatography-tandem mass spectrometry technology, so that separation and qualitative and quantitative detection of six p-phenylenediamine antioxidants and quinone derivatives in a sample are realized; meanwhile, the sensitivity is high, the quantity of isotope internal standards is small, the solvent loss is small, and the actual detection requirement is met.

The invention relates to an application of a five-membered heterocyclic pyrimidine diketone compound in preparation of herbicides, in particular to an application of the five-membered heterocyclic pyrimidine diketone compound in preparation of herbicides for preventing and controlling dicotyledonous weeds such as oilseed rape and amaranthus retroflexus. The compound disclosed by the invention has a good control effect on dicotyledonous weeds under the dosage of 100g / mu, and the weeding effect on amaranthus retroflexus is 100% during stem and leaf treatment. Chemical structural formula of five-membered heterocycle pyrimidinedione compound is as follows: # imgabs0 #

The invention provides a PVC (polyvinyl chloride) stabilizer for ultrathin-wall automobile wires and a preparation method of the PVC stabilizer. The PVC stabilizer for the ultrathin-wall automobile wire comprises the following components in parts by weight: 15-25 parts of calcium-zinc composite metal soap, 5-10 parts of hydrotalcite, 3-8 parts of a beta-diketone compound, 2-5 parts of a hindered phenol antioxidant, 1-3 parts of a phosphite ester antioxidant, 2-5 parts of a lubricant, 1-3 parts of an ultraviolet light absorber, 0.5-2 parts of a coupling agent, 4-5 parts of calcined clay and 5-15 parts of filler. According to the PVC stabilizer for the ultrathin-wall automobile wire and the preparation method of the PVC stabilizer, the calcium-zinc composite metal soap, the hydrotalcite, the beta-diketone compound and other stabilizers have a synergistic effect, so that the PVC stabilizer has excellent thermal stability; according to the present invention, the material can effectively inhibit the oxidative degradation of the PVC during the processing and using process, can prolong the service life of the wire, and can provide the good insulation stability through the minimum addition proportion of the calcined clay so as to ensure the thermal stability and the mechanical physical property of the material.

The invention relates to the technical field of intermediate membranes, in particular to a heat insulation type ionic intermediate membrane and a preparation method thereof.The heat insulation type ionic intermediate membrane is characterized in that hollow silicon dioxide nanotubes serve as filler, epoxy resin modified polyurethane emulsion serves as a base material, auxiliaries are added to prepare a heat insulation coating, and the ionic intermediate membrane layer is coated with the heat insulation coating to form a heat insulation layer; the preparation method comprises the following steps: carrying out amination on a hollow silicon dioxide nanotube by using 3-aminopropyltriethoxysilane, carrying out dehydration condensation on furan-2, 5-diketone and an amino group to synthesize maleimide so as to obtain a maleimide modified hollow silicon dioxide nanotube, and grafting furan carboxylic acid imidazolium salt polyionic liquid by using a Diels-Alder reaction so as to obtain a composite hollow silicon dioxide nanotube; aminated glass fibers, composite hollow silicon dioxide nanotubes, epoxy resin modified polyurethane emulsion and auxiliaries are mixed, and a reinforcing layer coating is obtained; and coating the lower surface of the ionic intermediate film layer with a reinforcing layer coating to form the reinforcing layer.

The invention belongs to the technical field of bioengineering, and particularly relates to a curcumin / dihydrocurcumin reductase mutant and application thereof. According to the curcumin / dihydrocurcumin reductase mutant obtained through screening, in the reaction of catalyzing 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-diketone to prepare tetrahydrocurcumin, the highest catalytic efficiency can reach 1641 mM <-1 > S <-1 >, the highest catalytic efficiency is 8.16 times that of initial curcumin / dihydrocurcumin reductase, the catalytic efficiency is greatly improved, and the curcumin can be used for preparing tetrahydrocurcumin by catalyzing 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-diketone. The production efficiency of the tetrahydrocurcumin is remarkably improved, and a novel method is provided for preparing the tetrahydrocurcumin.

The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl) thieno[2,3-d]pyrimidine-2,4 (1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

The invention discloses a novel method for synthesizing 1, 3-diketone organic matters, which comprises the following steps: by taking acyl chloride and silyl enol ether as raw materials, generating acyl free radicals through photo-induced copper catalysis, and carrying out free radical addition reaction on the acyl free radicals and silyl enol ether, thereby efficiently constructing 1, 3-diketone compounds. Compared with strong base, oxidant, high temperature and expensive metal catalyst required by the existing method, the method provided by the invention adopts the cheap and high-yield copper catalyst, so that the production cost is reduced, and the economic benefit is improved. In addition, the method has mild reaction conditions, easily available catalysts and raw materials, utilizes clean and sustainable light energy as driving force, is simple and convenient to operate, and is suitable for large-scale production. The invention provides an economic and environment-friendly innovative way for synthesizing the 1, 3-diketone compound, and has a wide application prospect.

The invention relates to the technical field of organic photoelectric materials, and particularly discloses a non-condensed ring small molecule acceptor material based on a quinonoid structure as well as a preparation method and application of the non-condensed ring small molecule acceptor material. According to the invention, easily available 1, 4-diacetyl piperazine-2, 5-diketone is used as a center, an alkyl chain and Ar are used for modification, EG is used as an end group, the non-condensed ring A-D-A '-D-A type structure acceptor material based on a quinone structure is constructed, and the general formula is shown in the specification. Wherein the PCE of the acceptor material which is modified by bithiophene and takes 2-(3-ethyl-4-oxothiazolidine-2-subunit) malononitrile as a terminal group reaches 15%. The non-condensed ring small molecule acceptor material based on the quinonoid structure is simple in synthesis process, and an effective strategy is provided for solving the problem of the overall performance of an organic solar cell.

Methods are provided for treating or preventing colorectal cancer, related diseases, or symptoms of any of the foregoing, e.g., familial adenomatous polyposis (FAP), in subjects of 55 years or older. The methods include administering 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4, 7-dione or a pharmaceutically acceptable salt thereof.

The invention relates to a rigid spiro compound and a preparation method and application thereof.The preparation method comprises the steps that 6-methylene-androstane-4-ene-3, 17-diketone (V) is dissolved in a mixed solution of dichloromethane and trifluoroacetic acid, reaction and reduced pressure distillation are conducted at the temperature of 20-25 DEG C, then extraction washing and distillation are conducted, a rigid spiro compound crude product can be obtained, and the rigid spiro compound is obtained. The crude product can be subjected to column chromatography separation and purification to obtain a refined rigid spiro compound (I). By adopting the preparation method, the friction and wear properties of the base oil are remarkably improved, and the base oil has lower friction coefficient and wear scar diameter, and has good application prospect as an antifriction and wear-resistant additive.

The invention relates to the technical field of lithium adsorbents, in particular to a preparation and application method of a porous microsphere adsorbent for extracting lithium, and the preparation method comprises the following steps: preparing a water phase solution containing methacrylic acid, water and an emulsifier; the preparation method comprises the following steps: preparing an oil phase solution containing a fluorinated methacrylate monomer containing beta-diketone, cyclohexyl methacrylate, methoxyethyl methacrylate, N, N-bis (acryloyl) cystamine, ethylene glycol dimethacrylate, azodiisobutyronitrile and a solvent; dropwise adding the oil-phase solution into the water-phase solution for gradient emulsification, adding sodium persulfate to initiate polymerization, and performing centrifugal drying to obtain porous microspheres; and immersing the porous microspheres into a NaOH solution for hydrolysis activation, and drying to obtain the porous microsphere adsorbent for selective adsorption of lithium ions. Wherein the beta-diketone can enhance the targeted adsorption effect of the adsorbent on lithium ions and has relatively high selectivity and adsorption capacity, and the strong electron-withdrawing property of CF3 further polarizes carbonyl and enhances the coordination ability of the lithium ions.

The invention provides a method for electrochemically preparing a high-compactness electron transport type electrode film on a non-conductive substrate, and the method comprises the following steps: S1, arranging an oxidizing agent, 3, 7-dihydrobenzo [1, 2-b: 4, 5-b '] difuran-2, 6-diketone and / or poly (3, 7-dihydrobenzo [1, 2-b: 4, 5-b'] difuran-2, 6-diketone) on a substrate to obtain a conductive film substrate layer; s2, 3, 7-dihydrobenzo [1, 2-b: 4, 5-b '] difuran-2, 6-diketone, a solvent and acid anhydride are mixed, and an electrolyte is obtained; s3, adding the conductive thin film substrate layer in the S1 into an electrolyte, and performing electrochemical polymerization by adopting a three-electrode system to obtain an electrochemical polymerization treatment thin film I; the preparation method further comprises the following steps: S4, adopting a three-electrode system, and carrying out reduction doping treatment on the electrochemical polymerization treatment film I to obtain a final conductive film II. The electrode film is good in compactness and stability, can be used as a cathode in an organic electronic device, and has the advantages of being high in conductivity, simple to process and prepare, suitable for flexible devices and the like.

The present invention provides triazinedione derivatives, their preparation methods, and their pharmaceutical applications. Specifically, the present invention provides triazinedione derivatives represented by general formula (I), their preparation methods, pharmaceutical compositions containing said derivatives, and uses thereof as therapeutic agents, particularly their use in the preparation of myosin inhibitors and in the preparation of drugs for treating hypertrophic cardiomyopathy (HCM) or cardiac diseases with pathophysiological characteristics associated with HCM. JPEG2023550444000158.jpg50170

The invention discloses a compound calcium-zinc stabilizer as well as a preparation method and application thereof, and relates to the field of calcium-zinc stabilizers. The calcium-zinc stabilizer comprises calcium stearate, zinc stearate, phosphite ester, an epoxy compound, lanthanum oxide, beta-diketone, a lubricant, an antioxidant and a filler. Uniformly mixing calcium stearate, zinc stearate and lanthanum oxide; adding phosphite ester, an epoxy compound and beta-diketone, and uniformly mixing; and adding the lubricant, the antioxidant and the filler, and uniformly mixing. The calcium-zinc stabilizer is applied to the field of PVC films. By adding calcium / zinc stearate as a main stabilizer and adding lanthanum oxide to be compounded with the main stabilizer, the thermal stability of the PVC film is further improved, and the initial whiteness and light transmittance of the PVC film are obviously improved compared with those of the PVC film in which lanthanum oxide is not added.

The invention provides a liquid sulfur removal agent and a preparation method thereof, and belongs to the technical field of natural gas hydrogen sulfide removal treatment.The liquid sulfur removal agent comprises, by weight, 36-66% of s-triazine derivatives, 5-8% of sulfolane, 2-5% of a pH control agent, 10-12% of a stabilizer, 5-8% of a scale inhibitor, 1-2% of a bactericide and the balance deionized water; wherein the s-triazine derivative is selected from a mixture of hexahydro-1, 3, 5-triacetyl-hexahydros-triazine, 1, 3, 5-triacetyl-hexahydros-triazine and 1, 3, 5-triazinane-2, 4-diketone, and the structural formula of the s-triazine derivative is shown in the description. The liquid sulfur removal agent is high in sulfur removal efficiency, good in corrosion inhibition and sterilization performance and not prone to scaling.

The invention belongs to the technical field of medicines, and discloses an application of a small molecule compound in preparation of a product for preventing and / or treating pulmonary arterial hypertension and complications thereof. The small molecule compound is 8-[[4-(cyclopropanecarbonyl) piperazine-1-yl] methyl]-1, 3-dimethyl-7-(3-methylbutyl) purine-2, 6-diketone, and the structural formula is as shown in a formula (I): # imgabs0. The small molecule compound and pharmaceutically acceptable salts thereof have a remarkable treatment effect on pulmonary arterial hypertension and complications thereof, and can be used for treating pulmonary arterial hypertension and complications thereof. The effects of preventing and / or treating the pulmonary arterial hypertension include the reduction of right heart hypertrophy, the reduction of right ventricular systolic pressure, right heart enlargement, right heart dysfunction, pulmonary vascular remodeling, pulmonary arterial intima thickness, increase of vascular myelization, pulmonary arterial smooth muscle cell proliferation and migration, the reduction of the right ventricular hypertrophy, the reduction of the right ventricular hypertrophy, the reduction of the right ventricular hypertrophy and the reduction of the right ventricular hypertrophy. The pulmonary arterial intima thickness and the vascular myelization level are improved, pulmonary vascular remodeling is reversed, and pulmonary artery smooth muscle cell proliferation and migration are inhibited.

Crosslinking aromatic compounds are described which have structure (I). Also described, are compositions including these crosslinking compounds, for instance ones which also comprising a photoacid generator. Also, described are methods of using such compositions to coat a substrate and by exposing it to radiation producing an image which may be used as a mask in the manufacture of microelectronics. Also disclosed is a selective iodination method for multiphenolic compounds at the ortho position to the phenol functionality, employing a 1-iodopyrrolidine-2,5-dione moiety in the presence of an arylsulfonic acid which produces the phenolic precursors of crosslinking aromatic compounds with selective iodination.

The invention discloses a preparation method of octafluorocyclopentene, which comprises the following two steps of: firstly, reacting 4-cyclopentene-1, 3-diketone with a selective fluorine reagent in acetonitrile under the condition of reflux to generate a crude product second mixture, purifying the second mixture, and putting the purified second mixture into a second-step reaction to obtain the octafluorocyclopentene. Reacting with diethylamino sulfur trifluoride in dichloromethane to generate a third mixture; the method has the advantages of environment-friendly and simple reaction process, no generation of three wastes, low cost, easy obtaining, simple reaction process, mild reaction, no generation of waste gas pollution even if nitrogen protection is needed, easy operation, and suitableness for industrial production.